Research Explorer

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Researcher

Ken Bracke

Publications & Research Data

Awards & Distinctions

162 Results

2026

CD4-directed nanoblades enable selective genome editing in CD4+ cells and HIV suppression in vitro and in vivo

Jolien Van CleemputMaaike De CockRianne VerbeekElianne BurgBram Van Den EeckhoutWojciech WitkowskiWillem van SnippenbergZoi StylianidouEmily Brugger GaleticMareva Delporte et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

Cigarette smoke-primed citrullinated HLA-DR4 T cell reactivity is modulated by γ8-T cells

Matthias JarlborgTine DecruyTeddy ManuelloJulie CoudenysRenée Van der CruyssenThomas MalfaitLeander MeurisTania MaesKen BrackeDiane van der Woude et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Developmental Endothelial Locus-1 (DEL-1), an endogenous inhibitor of neutrophil extravasation, is increased in the bronchial epithelium of COPD patients

Yiannis De MeersmanSebastian RiemannSara WijnantB VanaudenaerdeKen BrackeGuy BrusselleTania Maes

The role of miR-320d in regulation of cigarette smoke-induced pro-inflammatory responses in COPD

Mirjam RoffelCorry-Anke BrandsmaAlen FaizMarnix R JonkerWim TimensGuy JoosGuy BrusselleTania MaesKen BrackeMaarten van den Berge et al.

A1 Journal Article in ARCHIVOS DE BRONCONEUMOLOGIA

Update on the pathogenetic hallmarks of chronic obstructive pulmonary disease

Ken BrackeGuy Brusselle

A1 Journal Article in PRESSE MEDICALE

When clearance fails : the role of efferocytosis in COPD

Iris TournoySilke GeirnaertDmitri KryskoKen Bracke

A1 Journal Article in EUROPEAN RESPIRATORY REVIEW

2025

Altered levels of angiogenin and tRNA-derived fragments associate with severe asthma

Clara ClausJulieta B. GrossoMaria Belen MaravalMatias ArdussoOscar A. BottassoTania MaesKen BrackeGuy BrusselleMauro IbanezLedit R. F. Ardusso et al.

A1 Journal Article in SCIENTIFIC REPORTS

Genetic and environmental risk factors for asthma : towards prevention

Gerard KoppelmanMaria Pino-YanesErik MelénPippa PowellKen BrackeJuan CeledonGuy Brusselle

A1 Journal Article in LANCET RESPIRATORY MEDICINE

Histochemical staining underestimates peribronchial eosinophilic inflammation compared to ECP or GAL10 staining in human lung tissue

Yiannis De MeersmanIris JanssensSebastian RiemannJoyceline De VolderSara WijnantEva Van BraeckelBart LambrechtKen BrackeGuy BrusselleTania Maes

Pulmonary microvascular endothelial cells support alveolar epithelial growth via bone morphogenetic protein 6 secretion

Luke Van Der KoogXinhui WuDyan F. NugrahaAbilash RaviJustina C. WoltersFien VerhammePeter L. HorvatovichKen BrackeAnne M. van der DoesPieter S. Hiemstra et al.

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Vitronectin regulates lung tissue remodeling and emphysema in chronic obstructive pulmonary disease

Gang LiuAlan C. HsuSilke GeirnaertChristine CongPrema M. NairSj ShenJacqueline E. MarshallTatt Jhong HawMichael FrickerAshleigh M. Philp et al.

A1 Journal Article in MOLECULAR THERAPY

2024

Evaluating β2-agonists as siRNA delivery adjuvants for pulmonary surfactant-coated nanogel inhalation therapy

Pieterjan MerckxGRIET CONICKXEvy BlommeTania MaesKen BrackeGuy BrusselleStefaan De SmedtKoen Raemdonck

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Selective replacement of cholesterol with cationic amphiphilic drugs enables the design of lipid nanoparticles with improved RNA delivery

Bram BogaertAliona DebisschopThomas EhouarneHannelore Van EeckhoutteJoyceline De VolderAn JacobsEline PottieRiet De RyckeAurélie CrabbéPieter Mestdagh et al.

A1 Journal Article in NANO LETTERS

Unraveling the immune profile in emphysema using single-cell and imaging mass spectrometry

Editorial material

2023

Blunted adaptive immune responses and acute exacerbations of COPD : breaking the code

Ken BrackeFrancesca Polverino

Editorial material

Commensal bacteria of the lung microbiota synergistically inhibit inflammation in a three-dimensional epithelial cell model

Ellen GoeteynLucia GrassiSara Van den BosscheCharlotte RigautsYannick Vande WeygaerdeEva Van BraeckelTania MaesKen BrackeAurélie Crabbé

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Retrospective study shows that serum levels of chemokine CXCL10 and cytokine GDF15 support a diagnosis of sporadic inclusion body myositis and immune-mediated necrotizing myopathy

Boel De PaepeKen BrackeJan De Bleecker

A1 Journal Article in BRAIN SCIENCES

RIPK1 kinase-dependent inflammation and cell death contribute to the pathogenesis of COPD

Hannelore Van EeckhoutteChantal DonovanRichard Y. KimThomas M. ConlonMeshal AnsariHaroon KhanRanjith JayaramanNicole G. HansbroYves DondelingerTom Delanghe et al.

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

The role of regulated cell death in chronic obstructive pulmonary disease (COPD)

Hannelore Van EeckhoutteKen BrackeGuy BrusselleTom Vanden Berghe

TLR7 promotes smoke-induced experimental lung damage through the activity of mast cell tryptase

Gang LiuTatt Jhong HawMalcolm R. StarkeyAshleigh M. PhilpStelios PavlidisChristina NalkurthiPrema M. NairHenry M. GomezIrwan HanishAlan CY. Hsu et al.

A1 Journal Article in NATURE COMMUNICATIONS

Unlocking lncRNA functions through high-throughput CRISPR-interference screens in an in vitro airway inflammation model

Fien GysensPieter MestdaghKen BrackeTania Maes

2022

Adverse roles of mast cell chymase-1 in chronic obstructive pulmonary disease

Gang LiuAndrew G JarnickiKeshav R PaudelWenying LuRidhima WadhwaAshleigh M PhilpHannelore Van EeckhoutteJacqueline E MarshallVamshikrishna MalylaAngelica Katsifis et al.

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

An exploratory study of circulating cytokines and chemokines in patients with muscle disorders proposes CD40L and CCL5 represent general disease markers while CXCL10 differentiates between patients with an autoimmune myositis

Boel De PaepeKen BrackeJan De Bleecker

A2 Journal Article in CYTOKINE. X

B cells and their crosstalk with fibroblasts in chronic obstructive pulmonary disease (COPD) : translational research during the COVID-19 pandemic

Merel JacobsKen BrackeGuy Brusselle

Identification of asthma associated microRNAs in bronchial biopsies

Mirjam RoffelIlse M. BoudewijnJos L.L. van NijnattenAlen FaizCorneel J. VermeulenAntoon J. van OosterhoutKaren AffleckWim TimensKen BrackeTania Maes et al.

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

IL-10 producing regulatory B cells are decreased in blood from smokers and COPD patients

Merel JacobsSven VerschraegenBihiyga SalhiJasper AnckaertPieter MestdaghGuy BrusselleKen Bracke

A1 Journal Article in RESPIRATORY RESEARCH

MicroRNAs in Asthma and COPD : from biomarkers to regulators of disease pathogenesis

Mirjam RoffelIrene HeijinkTania MaesKen BrackeCorry-Anke Brandsma

Reduced protection of RIPK3-deficient mice against influenza by matrix protein 2 ectodomain targeted active and passive vaccination strategies

Teodora-Eugenia OlteanLorena IbanezTatyana DivertTine YsenbaertHannelore Van EeckhoutteVera GoossensMichael SchotsaertKen BrackeBert SchepensJonathan Maelfait et al.

A1 Journal Article in CELL DEATH & DISEASE

The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD

Gizem Guenes GuenselThomas M. ConlonAicha JeridiRinho KimZeynep ErtuezNiklas J. LangMeshal AnsariMariia NovikovaDongsheng JiangMaximilian Strunz et al.

A1 Journal Article in NATURE COMMUNICATIONS

2021

Effect of ACE1 polymorphism rs1799752 on protein levels of ACE2, the SARS-CoV-2 entry receptor, in alveolar lung epithelium

Merel JacobsLies LahousseHannelore Van EeckhoutteSara WijnantJoris DelangheGuy BrusselleKen Bracke

A1 Journal Article in ERJ OPEN RESEARCH

Epigenome-wide association study on diffusing capacity of the lung

Natalie TerzikhanHanfei XuAhmed Edris MohamedKen BrackeFien VerhammeBruno H. C. StrickerJosée DupuisLies LahousseGeorge T. O'ConnorGuy Brusselle

A1 Journal Article in ERJ OPEN RESEARCH

Hippocampal sclerosis in frontotemporal dementia : when vascular pathology meets neurodegeneration

Anne SiebenTim Van LangenhoveYannick VermeirenHelena GossyeMarleen PraetDimitri VanhauwaertCeline CousaertSebastiaan EngelborghsRobrecht RaedtPaul Boon et al.

A1 Journal Article in JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

MiR-223 is increased in lungs of patients with COPD and modulates cigarette smoke-induced pulmonary inflammation

Mirjam RoffelTania MaesCorry-Anke BrandsmaMaarten van den BergeBart M. VanaudenaerdeGuy JoosGuy BrusselleIrene H. HeijinkKen Bracke

A1 Journal Article in AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Necroptosis signalling promotes inflammation, airway remodelling and emphysema in COPD

Zhe LuHannelore Van EeckhoutteGang LiuPrema M NairBernadette JonesCaitlin GillisB. Christina NalkurthiFien VerhammeTamariche Buyle-HuybrechtPeter Vandenabeele et al.

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Organ-specific genome diversity of replication-competent SARS-CoV-2

Jolien Van CleemputWillem van SnippenbergLaurens LambrechtsAmélie DendoovenValentino D'OnofrioLiesbeth CouckWim TrypsteenJan VanrusseltSebastiaan TheunsNick Vereecke et al.

A1 Journal Article in NATURE COMMUNICATIONS

Quantification and role of innate lymphoid cell subsets in Chronic Obstructive Pulmonary Disease

Evy BlommeSharen ProvoostElise De SmetKatrien De GroveHannelore Van EeckhoutteJoyceline De VolderPhilip M HansbroMatteo BonatoMarina SaettaSara Wijnant et al.

A1 Journal Article in CLINICAL & TRANSLATIONAL IMMUNOLOGY

The RNA Atlas expands the catalog of human non-coding RNAs

Lucia LorenziHua-Sheng ChiuFrancisco Avila CobosStephen GrossPieter-Jan VoldersRobrecht CannoodtJustine NuytensKatrien VanderheydenJasper AnckaertSteve Lefever et al.

A1 Journal Article in NATURE BIOTECHNOLOGY

The RNA Atlas expands the catalog of human non-coding RNAs (June, 10.1038/s41587-021-00936-1, 2021)

Lucia LorenziHua-Sheng ChiuFrancisco Avila CobosStephen GrossPieter-Jan VoldersRobrecht CannoodtJustine NuytensKatrien VanderheydenJasper AnckaertSteve Lefever et al.

2020

Charting extracellular transcriptomes in the human biofluid RNA atlas

Eva HulstaertAnnelien MorlionFrancisco Avila CobosKimberly VerniersJustine NuytensEveline Vanden EyndeNurten YigitJasper AnckaertAnja GeertsPieter Hindryckx et al.

A1 Journal Article in CELL REPORTS

COVID-19, asthma, and inhaled corticosteroids : another beneficial effect of inhaled corticosteroids?

Tania MaesKen BrackeGuy Brusselle

Editorial material

Expression of ACE2, the SARS-CoV-2 receptor, in lung tissue of patients with type 2 diabetes

Sara WijnantMerel JacobsHannelore Van EeckhoutteBruno LapauwGuy JoosKen BrackeGuy Brusselle

A1 Journal Article in DIABETES

Fructosamine-3-kinase as a potential treatment option for age-related macular degeneration

Sander De BruyneCaroline Van den BroeckeHenk VrielinckSamira KhelifiOlivier De WeverKen BrackeManon HuizingNezahat BostonJonas HimpeMarijn Speeckaert et al.

A1 Journal Article in JOURNAL OF CLINICAL MEDICINE

Host-microbe cross-talk in the lung microenvironment : implications for understanding and treating chronic lung disease

Reinoud GosensPieter S. HiemstraIan M. AdcockKen BrackeRobert P. DicksonPhilip M. HansbroSusanne Krauss-EtschmannHermelijn H. SmitsFrank R. M. StassenSabine Bartel

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Increased expression of ACE2, the SARS-CoV-2 entry receptor, in alveolar and bronchial epithelium of smokers and COPD subjects

Merel JacobsHannelore Van EeckhoutteSara WijnantWim JanssensGuy JoosGuy BrusselleKen Bracke

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Inhaled corticosteroids and COVID-19 reply

Tania MaesKen BrackeGuy Brusselle

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Innate defense proteins BPIFA1/B1 and microRNAs in the pathogenesis of COPD

Elise De SmetGuy BrusselleKen BrackePieter Mestdagh

miR-223 : a key regulator in the innate immune response in asthma and COPD

Mirjam RoffelKen BrackeIrene H. HeijinkTania Maes

A1 Journal Article in FRONTIERS IN MEDICINE

The role of miR-155 in cigarette smoke-induced pulmonary inflammation and COPD

Elise De SmetHannelore Van EeckhoutteFrancisco Avila CobosEvy BlommeFien VerhammeSharen ProvoostSTIJN VERLEDENKoen VenkenTania MaesGuy Joos et al.

A1 Journal Article in MUCOSAL IMMUNOLOGY

Translational research into the effects of cigarette smoke on inflammatory mediators and epithelial TRPV1 in Crohn’s disease

Liesbeth AllaisStephanie VerschuereTania MaesRebecca De SmetSarah DevrieseBryan GonzalesHarald PeetersKoen Van CrombruggenClaus BachertMartine De Vos et al.

A1 Journal Article in PLOS ONE

2019

Bone morphogenetic protein 6 (BMP-6) modulates lung function, pulmonary iron levels and cigarette smoke-induced inflammation

Fien VerhammeElise De SmetWannes Van HoosteJoris DelangheSE VerledenGuy JoosGuy BrusselleKen Bracke

A1 Journal Article in MUCOSAL IMMUNOLOGY

Expression of receptor interacting protein kinase-3 and mixed lineage kinase domain-like protein in patients with COPD

Fien VerhammeHannelore Van EeckhoutteT Buyle-HuybrechtGuy BrussellePeter VandenabeeleTom Vanden BergheKen Bracke

GDF-15 in pulmonary and critical care medicine

Fien VerhammeChristine M FreemanGuy BrusselleKen BrackeJeffrey L Curtis

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Necroptosis is activated in and drives pathogenesis of COPD

M FrickerZ LuHannelore Van EeckhoutteG LiuFien VerhammeT Buyle-HuybrechtGuy BrusselleJ MurphyKen BrackeP Hansbro

The RNA Atlas, a single nucleotide resolution map of the human transcriptome

Lucia LorenziHua-Sheng ChiuFrancisco Avila CobosStephen GrossPieter-Jan VoldersRobrecht CannoodtJustine NuytensKatrien VanderheydenJasper AnckaertSteve Lefever et al.

2018

Association of innate defense proteins BPIFA1 and BPIFB1 with disease severity in COPD

Elise De SmetLeen SeysFien VerhammeBart M VanaudenaerdeGuy BrusselleColin D BingleKen Bracke

A1 Journal Article in INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

DPP4, the Middle East respiratory syndrome coronavirus receptor, is upregulated in lungs of smokers and chronic obstructive pulmonary disease patients

Leen SeysW WidagdoFien VerhammeAlex KleinjanWim JanssensGuy JoosKen BrackeBart L HaagmansGuy Brusselle

A1 Journal Article in CLINICAL INFECTIOUS DISEASES

Heritability and genome-wide association study of diffusing capacity of the lung

Natalie TerzikhanFangui SunFien VerhammeHieab HH AdamsDaan LothKen BrackeBruno HC StrickerLies LahousseJosée DupuisGuy Brusselle et al.

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Placental growth factor inhibition targets pulmonary angiogenesis and represents a therapy for hepatopulmonary syndrome in mice

Sarah RaevensAnja GeertsAnnelies ParidaensSander LefereXavier VerhelstAnne HoorensJo Van DorpeTania MaesKen BrackeChristophe Casteleyn et al.

A1 Journal Article in HEPATOLOGY

The role of microRNA-155 in cigarette smoke-induced inflammation

Elise De SmetPieter MestdaghFrancisco Avila CobosEvy BlommeFien VerhammeSharen ProvoostTania MaesGuy JoosGuy BrusselleKen Bracke

2017

Direct detection of circulating microRNAs unveiled the absence of microRNA-218-5p in smoker subjects : reply

Griet ConickxPieter MestdaghJo VandesompeleGuy BrusselleKen Bracke

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Elevated GDF-15 contributes to pulmonary inflammation upon cigarette smoke exposure

Fien VerhammeLeen SeysElise De SmetSharen ProvoostW JanssensDirk ElewautGuy JoosGuy BrusselleKen Bracke

A1 Journal Article in MUCOSAL IMMUNOLOGY

End-stage cystic fibrosis lung disease is characterised by a diverse inflammatory pattern : an immunohistochemical analysis

Elise J LammertynElly VandermeulenHannelore BellonStephanie EveraertsStijn E VerledenKathleen Van den EyndeKen BrackeGuy BrussellePieter C GoeminneErik K Verbeken et al.

A1 Journal Article in RESPIRATORY RESEARCH

Immunological diversity in phenotypes of chronic lung allograft dysfunction : a comprehensive immunohistochemical analysis

Elly VandermeulenElise LammertynStijn E VerledenDavid RuttensHannelore BellonMario RicciardiJana SomersKen BrackeKathleen Van Den EyndeThomas Tousseyn et al.

A1 Journal Article in TRANSPLANT INTERNATIONAL

Increased levels of enzymes involved in local estradiol synthesis in chronic obstructive pulmonary disease

GFJ KoningsNL ReynaertB DelvouxFien VerhammeKen BrackeGuy BrusselleA RomanoJHJ Vernooy

A1 Journal Article in MOLECULAR AND CELLULAR ENDOCRINOLOGY

microRNA profiling in lung tissue and bronchoalveolar lavage of cigarette smoke-exposed mice and in COPD patients : a translational approach

Griet ConickxFrancisco Avila CobosMaarten van den BergeAlen FaizWim TimensPieter S. HiemstraGuy JoosGuy BrussellePieter MestdaghKen Bracke

A1 Journal Article in SCIENTIFIC REPORTS

MicroRNA profiling reveals a role for microRNA-218-5p in the pathogenesis of chronic obstructive pulmonary disease

Griet ConickxPieter MestdaghFrancisco Avila CobosFien VerhammeTania MaesBart M VanaudenaerdeLeen SeysLies LahousseRichard Y KimAlan C Hsu et al.

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

MicroRNAs as future therapeutic targets in COPD?

Ken BrackePieter Mestdagh

Editorial material

Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD

Hoeke A BaarsmaWioletta Skronska-WasekKathrin MutzeFlorian CiolekDarcy E WagnerGerrit John-SchusterKatharina HeinzelmannAndreas GüntherKen BrackeMaylis Dagouassat et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Peripheral artery disease in patients with chronic obstructive pulmonary disease

Guy BrusselleKen BrackeMichel De Pauw

Editorial material

Reduced frizzled receptor 4 expression prevents WNT/β-catenin-driven alveolar lung repair in chronic obstructive pulmonary disease

Wioletta Skronska-WasekKathrin MutzeHoeke A BaarsmaKen BrackeHani N AlsafadiMareike LehmannRita CostaMariano StornaiuoloEttore NovellinoGuy Brusselle et al.

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Role of microRNAs in the pathogenesis of chronic obstructive pulmonary disease (COPD)

Griet ConickxGuy BrusselleKen Bracke

The role of dicer in alveolar macrophages and dendritic cells in smoke-induced inflammation

Elise De SmetPieter MestdaghS ProvoostLeen SeysGuy JoosKarim VermaelenGuy BrusselleKen Bracke

2016

Aggravation of allergic airway inflammation by cigarette smoke in mice is CD44-dependent

Smitha KumarEllen LanckackerMieke DentenerKen BrackeSharen ProvoostKatrien De GroveGuy BrusselleEmiel WoutersTania MaesGuy Joos

A1 Journal Article in PLOS ONE

Asthma inflammatory phenotypes show differential microRNA expression in sputum

Tania MaesFrancisco Avila CobosFlorence SchleichValentina SorbelloMonique HenketKatleen De PreterKen BrackeGriet ConickxClaire MesnilJo Vandesompele et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

B cells in chronic obstructive pulmonary disease : moving to center stage

Francesca PolverinoLeen SeysKen BrackeCaroline A Owen

A1 Journal Article in AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Characterization and quantification of innate lymphoid cell subsets in human lung

Katrien De GroveSharen ProvoostFien VerhammeKen BrackeGuy JoosTania MaesGuy Brusselle

A1 Journal Article in PLOS ONE

Chronic cigarette smoke exposure induces microbial and inflammatory shifts and mucin changes in the murine gut

Liesbeth AllaisFrederiek-Maarten KerckhofStephanie VerscheureKen BrackeRebecca De SmetDebby LaukensPieter Van den AbbeeleMartine De VosNico BoonGuy Brusselle et al.

A1 Journal Article in ENVIRONMENTAL MICROBIOLOGY

Kinetics of pulmonary angiogenesis in mouse common bile duct ligation-induced liver fibrosis

Sarah RaevensLindsey DevisscherAnnelies ParidaensEliene BogaertsSander LefereYves-Paul VandewynckelCHRISTINE CASTELEYNKen BrackeTania MaesXavier Verhelst et al.

LncRNAs in the context of Chronic Obstructive Pulmonary Disease (COPD) are associated to immune response and metabolism of xenobiotics

Francisco Avila CobosKen BrackeJo VandesompeleKimberly VerniersGuy JoosKatleen De PreterGuy BrussellePieter Mestdagh

Microrna-218-5p is implicated in the pathogenesis of chronic obstructive pulmonary disease

Griet ConickxPieter MestdaghFrancisco Avila CobosFien VerhammeTania MaesBM VanaudenaerdeLies LahousseGuy JoosJo VandesompeleKen Bracke et al.

Mucosal immunity in COPD : from mucociliary dysfunction to lymphoid follicles

Leen SeysGuy BrusselleKen Bracke

Rol van microRNA in neutrofiel astma

Tania MaesFrancisco Avila CobosFlorence SchleichValentina SorbelloMonique HenketKatleen De PreterKen BrackeGriet ConickxClaire MesnilJo Vandesompele et al.

A4 Journal Article in BLOEDVATEN HART LONGEN

2015

Airway surface dehydration aggravates cigarette smoke-induced hallmarks of COPD in mice

Leen SeysFien VerhammeLisa DupontElke DesauterJulia DuerrAyca Seyhan AgircanGriet ConickxGuy JoosGuy BrusselleMarcus A Mall et al.

A1 Journal Article in PLOS ONE

Elucidating COPD pathogenesis by large-scale genetic analyses

Guy BrusselleKen Bracke

Editorial material

Expression of citrulline and homocitrulline residues in the lungs of non-smokers and smokers : implications for autoimmunity in rheumatoid arthritis

Elena B LugliRaquel ESM CorreiaRoman FischerKarin LundbergKen BrackeAnna B MontgomeryBenedikt M KesslerGuy BrussellePatrick J Venables

A1 Journal Article in ARTHRITIS RESEARCH & THERAPY

Identification of differentially expressed microRNAs in neutrophilic asthma

Tania MaesKatleen De PreterFN SchleichM HenketKen BrackeLies LahoussePieter MestdaghGuy JoosGuy BrusselleR Louis

MicroRNA miR-22 drives TH17 responses in emphysema

Guy BrusselleKen Bracke

Editorial material

Non-coding RNAs in the pathogenesis of COPD

Elise De SmetPieter MestdaghJo VandesompeleGuy BrusselleKen Bracke

A1 Journal Article in THORAX

Role of B cell-activating factor in chronic obstructive pulmonary disease

Leen SeysFien VerhammeAnja SchinwaldHamida HammadDanen Mootoosamy CunoosamyClaudie Bantsimba-MalandaAlan SabirshEileen McCallLiz FlavellRonald Herbst et al.

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Role of lymphoid follicles and transforming growth factor (TGF)-β superfamily in the pathogenesis of chronic obstructive pulmonary disease (COPD)

Fien VerhammeGuy BrusselleKen Bracke

Targeted therapy with inhaled corticosteroids in COPD according to blood eosinophil counts

Guy BrusselleKen BrackeLies Lahousse

Editorial material

The effect of cigarette smoke exposure on the development of inflammation in lungs, gut and joints of TNFΔARE mice

Liesbeth AllaisSmitha KumarKarlijn DebusschereStephanie VERSCHUERETania MaesRebecca De SmetGriet ConickxMartine De VosDebby LaukensGuy Joos et al.

A1 Journal Article in PLOS ONE

Transforming growth factor-β superfamily in obstructive lung diseases: more suspects than TGF-β alone

Fien VerhammeKen BrackeGuy JoosGuy Brusselle

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

2014

A comparative study of matrix remodeling in chronic models for COPD: mechanistic insights into the role of TNF-α

Irene MJ EurlingsMieke A DentenerEvi M MerckenRafael de CaboKen BrackeJuanita HJ VernooyEmiel FM WoutersNiki L Reynaert

A1 Journal Article in AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Cigarette smoke exposure alters the development of inflammation in experimental Crohn-like colitis

Liesbeth AllaisStephanie VerscheureKen BrackeRebecca De SmetDebby LaukensClaus BachertMartine De VosGuy BrusselleClaude Cuvelier

Cigarette smoke extract induces a phenotypic shift in epithelial cells: involvement of HIF1α in mesenchymal transition

Irene MJ EurlingsNiki L ReynaertTwan van den BeuckenHarry R GoskerCC de TheijeFien VerhammeKen BrackeEmiel FM WoutersMieke A Dentener

A1 Journal Article in PLOS ONE

Genome-wide association analysis identifies six new loci associated with forced vital capacity

Daan W LothMaria Soler ArtigasSina A GharibLouise V WainNora FranceschiniBeate KochTess D PottingerAlbert Vernon SmithQing DuanChris Oldmeadow et al.

A1 Journal Article in NATURE GENETICS

Inflammasomes in respiratory disease: from bench to bedside

Guy BrusselleSharen ProvoostKen BrackeAnna KuchmiyMohamed Lamkanfi

A1 Journal Article in CHEST

Investigation of 5-HT4 receptors in bronchial hyperresponsiveness in cigarette smoke-exposed mice

Lisa DupontKen BrackeJoris H De MaeyerValérie CompanGuy JoosRomain LefebvreGuy Brusselle

A1 Journal Article in PULMONARY PHARMACOLOGY & THERAPEUTICS

Role of activin-A in cigarette smoke-induced inflammation and COPD

Fien VerhammeKen BrackeGimano D AmatngalimGeert M VerledenGeert Van PottelbergePieter S HiemstraGuy JoosGuy Brusselle

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Role of the nitric oxide-soluble guanylyl cyclase pathway in obstructive airway diseases

Lisa DupontConstantinos GlynosKen BrackePeter BrouckaertGuy Brusselle

A1 Journal Article in PULMONARY PHARMACOLOGY & THERAPEUTICS

Targeting immune pathways for therapy in asthma and chronic obstructive pulmonary disease

Guy BrusselleKen Bracke

A2 Journal Article in ANNALS OF THE AMERICAN THORACIC SOCIETY

The effect of chronic cigarette smoke exposure on gut microbial diversity in healthy mice

Liesbeth AllaisFrederiek-Maarten KerckhofStephanie VerscheureKen BrackeRebecca De SmetDebby LaukensPieter Van den AbbeeleMartine De VosNico BoonGuy Brusselle et al.

The effect of chronic cigarette smoke exposure on the gut microbiome in healthy mice

Liesbeth AllaisFrederiek-Maarten KerckhofStephanie VerscheureKen BrackeRebecca De SmetDebby LaukensPieter Van den AbbeeleMartine De VosNico BoonGuy Brusselle et al.

2013

Chronic cigarette smoke exposure alters the murine gut microbiome

Liesbeth AllaisFrederiek-Maarten KerckhofStephanie VerscheureKen BrackeRebecca De SmetDebby LaukensMartine De VosNico BoonGuy BrusselleTom Van de Wiele et al.

Chronic cigarette smoke exposure alters the murine gut microbiome

Liesbeth AllaisFrederiek-Maarten KerckhofStephanie VerschuereKen BrackeRebecca De SmetDebby LaukensMartine De VosNico BoonGuy BrusselleTom Van de Wiele et al.

Chronic cigarette smoke exposure alters the murine gut microbiome

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Eosinophilic airway inflammation in nonallergic asthma

Guy BrusselleTania MaesKen Bracke

Editorial material

Leptin as regulator of pulmonary immune responses: involvement in respiratory diseases

Juanita HJ VernooyNiki DJ UbagsGuy BrusselleJan TavernierBenjamin T SurattGuy JoosEmiel FM WoutersKen Bracke

A1 Journal Article in PULMONARY PHARMACOLOGY & THERAPEUTICS

Role of CXCL13 in cigarette smoke-induced lymphoid follicle formation and chronic obstructive pulmonary disease

Ken BrackeFien VerhammeLeen SeysClaudie Bantsimba-MalandaDanen Mootoosamy CunoosamyRonald HerbstHamida HammadBart LambrechtGuy JoosGuy Brusselle

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The role of soluble guanylyl cyclase in Chronic Obstructive Pulmonary Disease

Constantinos GlynosLisa DupontTheodoros VassilakopoulosAndreas PapapetropoulosPeter BrouckaertAthanassios GiannisGuy JoosKen BrackeGuy Brusselle

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

2012

Altered cigarette smoke-induced lung inflammation due to ablation of Grx1

Ine KuipersKen BrackeGuy BrusselleScott W AesifRenske KrijgsmanIlja C ArtsEmiel FM WoutersNiki L Reynaert

A1 Journal Article in PLOS ONE

Chronic rejection pathology after orthotopic lung transplantation in mice : the development of a murine BOS model and its drawbacks

Stephanie De VleeschauwerWolfgang JungraithmayrShana WautersStijn WillemsManuela RinaldiAnnemie VaneylenStijn VerledenAnna Willems-WidyastutiKen BrackeGuy Brusselle et al.

A1 Journal Article in PLOS ONE

Cigarette smoke and the terminal ileum: increased autophagy in murine follicle-associated epithelium and Peyer's patches

Stephanie VERSCHUERELiesbeth AllaisKen BrackeSaskia LippensRebecca De SmetPeter VandenabeeleGuy BrusselleClaude Cuvelier

A1 Journal Article in HISTOCHEMISTRY AND CELL BIOLOGY

COPD is associated with reduced pulmonary interstitial expression of pentraxin-3

Geert Van PottelbergeKen BrackeNele PauwelsFrank VermassenGuy JoosGuy Brusselle

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Smoke decreases reversible oxidations S-glutathionylation and S-nitrosylation in mice

Ine KuipersKen BrackeGuy BrusselleEmiel F WoutersNiki L Reynaert

A1 Journal Article in FREE RADICAL RESEARCH

2011

Activation of the WNT/β-catenin pathway attenuates experimental emphysema

Nikolaus KneidingerAli Oender YildirimLens CallegariShinji TakenakaMaria Magdalena SteinRio DumitrascuAlexander BohlaKen BrackeRory E MortyGuy Brusselle et al.

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Chronic smoke exposure is associated with autophagy in murine Peyer's patches

Stephanie VERSCHUEREKen BrackeRebecca De SmetLiesbeth AllaisGuy BrusselleClaude Cuvelier

Cigarette smoking alters epithelial apoptosis and immune composition in murine GALT

Stephanie VERSCHUEREKen BrackeTine DemoorMaud PlantingaPhebe VerbruggheLiesbeth FerdinandeBart LambrechtGuy BrusselleClaude Cuvelier

A1 Journal Article in LABORATORY INVESTIGATION

Cigarette smoking alters intestinal barrier function and Peyer's Patch composition

Stephanie VERSCHUEREKen BrackeTine DemoorMaud PlantingaBart LambrechtGuy BrusselleClaude Cuvelier

Exacerbation of cigarette smoke-induced pulmonary inflammation by Staphylococcus aureus enterotoxin B in mice

Wouter HuvenneEllen LanckackerOlga KryskoKen BrackeTine DemoorPeter W HellingsGuy BrusselleGuy JoosClaus BachertTania Maes

A1 Journal Article in RESPIRATORY RESEARCH

MicroRNA expression in induced sputum of smokers and patients with chronic obstructive pulmonary disease

Geert Van PottelbergePieter MestdaghKen BrackeOlivier ThasYANNICK VAN DURMEGuy JoosJo VandesompeleGuy Brusselle

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

New insights into the immunology of chronic obstructive pulmonary disease

Guy BrusselleGuy JoosKen Bracke

A1 Journal Article in LANCET

Role of IL-1α and the Nlrp3/caspase-1/IL-1β axis in cigarette smoke-induced pulmonary inflammation and COPD

NS PauwelsKen BrackeLisa DupontGeert Van PottelbergeSharen ProvoostTom Vanden BerghePeter VandenabeeleBart LambrechtGuy JoosGuy Brusselle

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

The role of ChemR23 in the induction and resolution of cigarette smoke-induced inflammation

Tine DemoorKen BrackeLisa DupontMaud PlantingaBenjamin BondueMarie-Odile RoyVincent LannoyBart LambrechtGuy BrusselleGuy Joos

A1 Journal Article in JOURNAL OF IMMUNOLOGY

2010

Cigarette smoke induces PTX3 expression in pulmonary veins of mice in an IL-1 dependent manner

Nele PauwelsKen BrackeTania MaesGeert Van PottelbergeCecilia GarlandaAlberto MantovaniGuy JoosGuy Brusselle

A1 Journal Article in RESPIRATORY RESEARCH

Different regulation of cigarette smoke induced inflammation in upper versus lower airways

Wouter HuvenneClaudina Perez NovoLara DeryckeNatalie De RuyckOlga KryskoTania MaesNele PauwelsLander RobaysKen BrackeGuy Joos et al.

A1 Journal Article in RESPIRATORY RESEARCH

Enhanced deposition of low-molecular-weight hyaluronan in lungs of cigarette smoke-exposed mice

Ken BrackeMieke A DentenerEleni PapakonstantinouJuhanita HJ VernooyTine DemoorNele PauwelsJack CleutjensRobert Jan van SuylenGuy JoosGuy Brusselle et al.

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Increased T-regulatory cells in lungs and draining lymph nodes in a murine model of COPD

Tine DemoorKen BrackeGuy JoosGuy Brusselle

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Leptin modulates innate and adaptive immune cell recruitment after cigarette smoke exposure in mice

JHJ VernooyKen BrackeNEA DrummenNSA PauwelsLennart ZabeauRJ van SuylenJan TavernierGuy JoosEFM WoutersGuy Brusselle

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Plasmacytoid dendritic cells in pulmonary lymphoid follicles of patients with COPD

Geert Van PottelbergeKen BrackeSarah Van den BroeckSuzanne M ReinartzCornelis M van DrunenEmiel FM WoutersGeert M VerledenFrank VermassenGuy JoosGuy Brusselle

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Plasmacytoid dendritic cells in pulmonary lymphoid follicles of patients with COPD

Geert Van PottelbergeKen BrackeSarah Van den BroeckSuzanne ReinartzCornelis M van DrunenEmiel FM WoutersGeert M VerledenFrank VermassenGuy JoosGuy Brusselle

Reduced expression of pentraxin-3 in the lungs of patients with COPD

Geert Van PottelbergeKen BrackeN PauwelsYANNICK VAN DURMEGM VerledenFrank VermassenGuy JoosGuy Brusselle

Selective accumulation of Langerhans-type dendritic cells in small airways of patients with COPD

Geert Van PottelbergeKen BrackeIngel DemedtsKim De RijckSuzanne ReinartzCornelis van DrunenGeert VerledenFrank VermassenGuy JoosGuy Brusselle

A1 Journal Article in RESPIRATORY RESEARCH

The role of interleukin-6 in pulmonary and systemic manifestations in a murine model of chronic obstructive pulmonary disease

Nele PauwelsKen BrackeTania MaesCharles PiletteGuy JoosGuy Brusselle

A1 Journal Article in EXPERIMENTAL LUNG RESEARCH

2009

CCR7 Modulates Pulmonary and Lymph Node Inflammatory Responses in Cigarette Smoke-Exposed Mice

Tine DemoorKen BrackeKarim VermaelenLisa DupontGuy JoosGuy Brusselle

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Cigarette smoke induces apoptosis in the follicle-associated epithelium of murine Peyer's patches

Stephanie VERSCHUEREPhilip VlummensPhebe VerbruggheKen BrackeIsabelle RottiersGuy BrusselleClaude Cuvelier

Concomittant inhalation of cigarette smoke and aerosolized protein activates airway dendritic cells and induces allergic airway inflammation in a TLR-independent way

Lander RobaysEllen LanckackerKatrien MoerlooseTania MaesKen BrackeGuy BrusselleGuy JoosKarim Vermaelen

A1 Journal Article in Journal of Immunology

Effects of vagus nerve stimulation on pro- and anti-inflammatory cytokine induction in patients with refractory epilepsy

Veerle De HerdtSara BogaertKen BrackeRobrecht RaedtMartine De VosKristl VonckPaul Boon

A1 Journal Article in JOURNAL OF NEUROIMMUNOLOGY

Enhanced pulmonary leptin expression in patients with severe COPD and asymptomatic smokers

JHJ VernooyNEA DrummenRJ Van SuylenRHE ClootsGM MollerKen BrackeS ZuyderduynMA DentenerGuy BrussellePS Hiemstra et al.

A1 Journal Article in Thorax

Extrapulmonary manifestations of chronic obstructive pulmonary disease in a mouse model of chronic cigarette smoke exposure

Ken BrackeGuy JoosGuy Brusselle

A1 Journal Article in American Journal of Respiratory Cell and Molecular Biology

Lymphoid follicles in (very) severe COPD: beneficial or harmful?

Guy BrusselleTine DemoorKen BrackeC.-A. BrandsmaW. Timens

A1 Journal Article in European Respiratory Journal

Role of Lymphotoxin (alpha) in Cigarette Smoke-Induced Inflammation and Lymphoid Neogenesis

Tine DemoorKen BrackeTania MaesBERNARD VANDOORENDirk ElewautCharles PiletteGuy JoosGuy Brusselle

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Role of tachykinin NK1 receptor in a murine model of cigarette-smoke induced pulmonary inflammation

Katelijne De SwertKen BrackeTine DemoorGuy BrusselleGuy Joos

A1 Journal Article in Respiratory Research

The Role of Dendritic Cells in the Pathogenesis of COPD: Liaison Officers in the Front Line

Geert Van PottelbergeKen BrackeGuy JoosGuy Brusselle

A1 Journal Article in COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

2008

Comment on "cigarette smoke-induced pulmonary inflammation is TLR4/MyD88 and IL-1R1/MyD88 signaling dependent"

Tania MaesKen BrackeGuy JoosGuy Brusselle

A1 Journal Article in JOURNAL OF IMMUNOLOGY

TNF alpha receptor genotype influences smoking-induced muscle-fibre-type shift and atrophy in mice

Boel De PaepeGuy BrusselleTania MaesKim CreusSophie D'hoseNele D'HaeseKen BrackeAn D'hulstGuy JoosJan De Bleecker

A1 Journal Article in ACTA NEUROPATHOLOGICA

2007

Accumulation of dendritic cells and increased CCL20 levels in the airways of patients with chronic obstructive pulmonary disease

Ingel DemedtsKen BrackeGeert Van PottelbergeDries TestelmansGeert M VerledenFrank VermassenGuy JoosGuy Brusselle

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

CC-chemokine receptors in chronic obstructive pulmonary disease

Ken BrackeIngel DemedtsGuy JoosGuy Brusselle

A2 Journal Article in INFLAMMATION & ALLERGY : DRUG TARGETS

Cigarette smoke-induced pulmonary inflammation, but not airway remodelling, is attenuated in chemokine receptor 5-deficient mice

Ken BrackeAn D'hulstTania MaesINGEL DEMEDTSKatrien MoerlooseWA KUZIELGuy JoosGuy Brusselle

A1 Journal Article in CLINICAL AND EXPERIMENTAL ALLERGY

Role of proteases and chemokine receptors in a murine model of chronic obstructive pulmonary disease

Ken BrackeG BrusselleG JoosR Pauwels

2006

Cigarette smoke-induced pulmonary inflammation and emphysema are attenuated in CCR6-deficient mice

Ken BrackeAn D'hulstTania MaesKatrien MoerlooseIngel DemedtsS LEBECQUEGuy JoosGuy Brusselle

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Different roles for human lung dendritic cell subsets in pulmonary immune defense mechanisms

Ingel DemedtsKen BrackeTania MaesGuy JoosGuy Brusselle

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Murine models of COPD

Guy BrusselleKen BrackeTania MaesAn D'hulstKatrien MoerlooseGuy JoosRomain Pauwels

A1 Journal Article in PULMONARY PHARMACOLOGY & THERAPEUTICS

Murine TLR4 is implicated in cigarette smoke-induced pulmonary inflammation

Tania MaesKen BrackeKarim VermaelenIngel DemedtsGuy JoosRomain PauwelsGuy Brusselle

A1 Journal Article in INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Role of apoptosis in the pathogenesis of COPD and pulmonary emphysema

Ingel DemedtsTine DemoorKen BrackeGuy JoosGuy Brusselle

A1 Journal Article in RESPIRATORY RESEARCH

Role of tumour necrosis factor-alpha receptor p75 in cigarette smoke-induced pulmonary inflammation and emphysema

An D'hulstKen BrackeTania MaesJan De BleeckerRomain PauwelsGuy JoosGuy Brusselle

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

2005

Cigarette smoke-induced pulmonary emphysema in scid-mice. Is the acquired immune system required?

An D'hulstTania MaesKen BrackeIngel DemedtsKurt TournoyGuy JoosGuy Brusselle

A1 Journal Article in RESPIRATORY RESEARCH

Matrix metalloproteinase-12 and cathepsin D expression in pulmonary macrophages and dendritic cells of cigarette smoke-exposed mice

Ken BrackeD CATALDOTania MaesM GUEDERSA NOELJM FOIDARTGuy BrusselleRomain Pauwels

A1 Journal Article in INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Matrix metalloproteinases in asthma and COPD

Ingel DemedtsGuy BrusselleKen BrackeKarim VermaelenRomain Pauwels

A1 Journal Article in CURRENT OPINION IN PHARMACOLOGY

2003

Physicochemical and biological evaluation of cationic polymethacrylates as vectors for gene delivery

Peter DubruelBart ChristiaensBerlinda VanlooKen BrackeMaryvonne RosseneuJoël VandekerckhoveEtienne Schacht

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

2002

Synthetic polyamines as vectors for gene delivery

Peter DubruelJoost De StryckerPhilippe WestbroekKen BrackeEduard TemmermanJ VandervoortA LudwigEtienne Schacht

A1 Journal Article in POLYMER INTERNATIONAL