Research Explorer

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Researcher

Kelly Van Looveren

Awards & Distinctions

17 Results

2022

Point mutation I634A in the glucocorticoid receptor causes embryonic lethality by reduced ligand binding

Steven TimmermansNicolette J.D. VerhoogKelly Van LooverenSylviane DewaeleTino HochepiedMelanie EggermontBarbara GilbertAnne Boerema-de MunckTineke VanderhaeghenJoke Vanden Berghe et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Reprogramming of glucocorticoid receptor function by hypoxia

Tineke VanderhaeghenSteven TimmermansDeepika WattsVille PaakinahoMelanie EggermontJolien VandewalleCharlotte WallaeysLise Van WyngeneKelly Van LooverenLouise Nuyttens et al.

A1 Journal Article in EMBO REPORTS

2021

Combined glucocorticoid resistance and hyperlactatemia contributes to lethal shock in sepsis

Jolien VandewalleSteven TimmermansVille PaakinahoLies VancraeynestLiza DewyseTineke VanderhaeghenCharlotte WallaeysLise Van WyngeneKelly Van LooverenLouise Nuyttens et al.

A1 Journal Article in CELL METABOLISM

ZBTB32 performs crosstalk with the glucocorticoid receptor and is crucial in glucocorticoid responses to starvation

Lise Van WyngeneTineke VanderhaeghenIoanna PettaSteven TimmermansKatrien CorbeelsBart Van der SchuerenJolien VandewalleKelly Van LooverenCharlotte WallaeysMelanie Eggermont et al.

A1 Journal Article in ISCIENCE

2020

An extracellular microRNA can rescue lives in sepsis

Kelly Van LooverenLise Van WyngeneClaude Libert

Editorial material

Glucocorticoids limit lipopolysaccharide-induced lethal inflammation by a double control system

Kelly Van LooverenSteven TimmermansTineke VanderhaeghenCharlotte WallaeysMarlies BallegeerJolien SouffriauMelanie EggermontJolien VandewalleLise Van WyngeneKarolien De Bosscher et al.

A1 Journal Article in EMBO REPORTS

Hepatic PPARα function and lipid metabolic pathways are dysregulated in polymicrobial sepsis

Lise Van WyngeneTineke VanderhaeghenSteven TimmermansJolien VandewalleKelly Van LooverenJolien SouffriauCharlotte WallaeysMelanie EggermontSam ErnstEvelien Van Hamme et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

Potential of glucocorticoids to treat intestinal inflammation during sepsis

Kelly Van LooverenCharlotte WallaeysClaude Libert

A1 Journal Article in CURRENT OPINION IN PHARMACOLOGY

The glucocorticoid receptor in acute inflammation : new molecular insights and development of a new GR dimerization mutant

Kelly Van LooverenClaude LibertKarolien De Bosscher

Zinc inhibits lethal inflammatory shock by preventing microbe-induced interferon signature in intestinal epithelium

Jolien SouffriauSteven TimmermansTineke VanderhaeghenCharlotte WallaeysKelly Van LooverenLindsy AelbrechtSylviane DewaeleJolien VandewalleEvy GoossensSerge Verbanck et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

2019

Cognitive dysfunction in mice lacking proper glucocorticoid receptor dimerization

Kelly Van LooverenMichiel Van BoxelaereZsuzsanna Callaerts-VeghClaude Libert

A1 Journal Article in PLOS ONE

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile

Karen DendonckerSteven TimmermansJolien VandewalleMelanie EggermontJoanna LempiäinenVille PaakinahoEvelien Van HammeSylviane DewaeleSofie VandevyverMarlies Ballegeer et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2018

A screening assay for Selective Dimerizing Glucocorticoid Receptor Agonists and Modulators (SEDIGRAM) that are effective against acute inflammation

Jolien SouffriauMelanie EggermontSara Van RyckeghemKelly Van LooverenLise Van WyngeneEvelien Van HammeMarnik VuylstekeRudi BeyaertKarolien De BosscherClaude Libert

A1 Journal Article in SCIENTIFIC REPORTS

Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice

Marlies BallegeerKelly Van LooverenSteven TimmermansMelanie EggermontSofie VandevyverFabien Henri TheryKaren DendonckerJolien SouffriauJolien VandewalleLise Van Wyngene et al.

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

Should we target TNF receptors in the intestinal epithelium with glucocorticoids during systemic inflammation?

Kelly Van LooverenClaude Libert

A1 Journal Article in EXPERT OPINION ON THERAPEUTIC TARGETS

Using the inbred mouse strain SPRET/EiJ to provide novel insights in inflammation and infection research

Steven TimmermansJolien SouffriauJolien VandewalleLise Van WyngeneKelly Van LooverenTineke VanderhaeghenClaude Libert

A1 Journal Article in MAMMALIAN GENOME

2017

The nature of the GRE influences the screening for GR-activity enhancing modulators

Karen DendonckerSteven TimmermansKelly Van LooverenLode De CauwerKarolien De BosscherClaude Libert

A1 Journal Article in PLOS ONE