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Researcher
Kathlyn Laval
Profile
Projects
Publications
Activities
Awards & Distinctions
30
Results
2025
Genomic analysis and replication kinetics of the closely related EHV-1 neuropathogenic 21P40 and abortigenic 97P70 strains
Eslam Mohamed
Ines Zarak
Nick Vereecke
Sebastiaan Theuns
Kathlyn Laval
Hans Nauwynck
A1
Journal Article
in
VETERINARY RESEARCH
2025
2024
Aspergillus fumigatus spore proteases alter the respiratory mucosa architecture and facilitate equine herpesvirus 1 infection
Joren Portaels
Eline Van Crombrugge
Wim Van Den Broeck
Katrien Lagrou
Kathlyn Laval
Hans Nauwynck
A1
Journal Article
in
VIRUSES-BASEL
2024
The alphaherpesvirus gE/gI glycoprotein complex and proteases jointly orchestrate invasion across the host’s upper respiratory epithelial barrier
Eline Van Crombrugge
Xiaolei Ren
Sarah Glorieux
Ines Zarak
Wim Van Den Broeck
Claus Bachert
Nan Zhang
Thibaut Van Zele
D. Kim
G. A. Smith
et al.
A1
Journal Article
in
MBIO
2024
2023
Pseudorabies virus hijacks DDX3X, initiating an addictive 'mad itch' and immune suppression, to facilitate viral spread
Shane J. F. Cronin
Miguel A. Tejada
Ren Song
Kathlyn Laval
Domagoj Cikes
Ming Ji
Annalaura Brai
Johannes Stadlmann
Maria Novatchikova
Thomas Perlot
et al.
Preprint
2023
2022
Bacterial toxins from Staphylococcus aureus and Bordetella bronchiseptica predispose the horse’s respiratory tract to equine herpesvirus type 1 infection
Eline Van Crombrugge
Emma Vanbeylen
Jolien Van Cleemput
Wim Van Den Broeck
Kathlyn Laval
Hans Nauwynck
A1
Journal Article
in
VIRUSES-BASEL
2022
2021
CRISPR/Cas9-constructed pseudorabies virus mutants reveal the importance of UL13 in alphaherpesvirus escape from genome silencing
Jolien Van Cleemput
Orkide O. Koyuncu
Kathlyn Laval
Esteban A. Engel
Lynn W. Enquist
A1
Journal Article
in
JOURNAL OF VIROLOGY
2021
The pathogenesis and immune evasive mechanisms of equine herpesvirus type 1
Kathlyn Laval
Katrien C. K. Poelaert
Jolien Van Cleemput
Jing Zhao
Annelies P. Vandekerckhove
Annick C. Gryspeerdt
Barbara Garré
Karen van der Meulen
Hossein B. Baghi
Haileleul N. Dubale
et al.
A1
Journal Article
in
FRONTIERS IN MICROBIOLOGY
2021
The potential role of herpes simplex virus type 1 and neuroinflammation in the pathogenesis of Alzheimer's disease
Kathlyn Laval
Lynn W. Enquist
A1
Journal Article
in
FRONTIERS IN NEUROLOGY
2021
2020
An alphaherpesvirus exploits antimicrobial beta-defensins to initiate respiratory tract infection
Jolien Van Cleemput
Katrien Poelaert
Kathlyn Laval
Nathalie Vanderheijden
Maarten Dhaenens
Simon Daled
Filip Boyen
Frank Pasmans
Hans Nauwynck
A1
Journal Article
in
JOURNAL OF VIROLOGY
2020
Mouse footpad inoculation model to study viral-induced neuroinflammatory responses
Kathlyn Laval
Carola J. Maturana
Lynn W. Enquist
A1
Journal Article
in
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
2020
The neuropathic itch caused by pseudorabies virus
Kathlyn Laval
Lynn W. Enquist
A1
Journal Article
in
PATHOGENS
2020
2019
Alphaherpesvirus infection of mice primes PNS neurons to an inflammatory state regulated by TLR2 and type I IFN signaling
Kathlyn Laval
Jolien Van Cleemput
Jonah Vernejoul
Lynn Enquist
A1
Journal Article
in
PLOS PATHOGENS
2019
Beyond gut instinct : metabolic short-chain fatty acids moderate the pathogenesis of alphaherpesviruses
Katrien Poelaert
Jolien Van Cleemput
Kathlyn Laval
Sarah Descamps
Herman Favoreel
Hans Nauwynck
A1
Journal Article
in
FRONTIERS IN MICROBIOLOGY
2019
Deoxynivalenol, but not fumonisin B1, aflatoxin B1 or diesel exhaust particles disrupt integrity of the horse's respiratory epithelium and predispose it for equine herpesvirus type 1 infection
Jolien Van Cleemput
Katrien Poelaert
Kathlyn Laval
Wim Van Den Broeck
Hans Nauwynck
A1
Journal Article
in
VETERINARY MICROBIOLOGY
2019
Equine herpesvirus 1 bridles T lymphocytes to reach its target organs
Katrien Poelaert
Jolien Van Cleemput
Kathlyn Laval
Herman Favoreel
Liesbeth Couck
Wim Van Den Broeck
Walid Azab
Hans Nauwynck
A1
Journal Article
in
JOURNAL OF VIROLOGY
2019
Equine herpesvirus 1 infection orchestrates the expression of chemokines in equine respiratory epithelial cells
Katrien Poelaert
Jolien Van Cleemput
Kathlyn Laval
Jiexiong Xie
Herman Favoreel
Hans Nauwynck
A1
Journal Article
in
JOURNAL OF GENERAL VIROLOGY
2019
Pollens destroy respiratory epithelial cell anchors and drive alphaherpesvirus infection
Jolien Van Cleemput
Katrien Poelaert
Kathlyn Laval
Francis Impens
Wim Van Den Broeck
Kris Gevaert
Hans Nauwynck
A1
Journal Article
in
SCIENTIFIC REPORTS
2019
Unravelling the first key steps in equine herpesvirus type 5 (EHV5) pathogenesis using ex vivo and in vitro equine models
Jolien Van Cleemput
Katrien Poelaert
Kathlyn Laval
Hans Nauwynck
A1
Journal Article
in
VETERINARY RESEARCH
2019
2018
Abortigenic but not neurotropic equine herpes virus 1 modulates the interferon antiviral defense
Katrien Poelaert
Jolien Van Cleemput
Kathlyn Laval
Herman Favoreel
Gisela Soboll Hussey
Roger K Maes
Hans Nauwynck
A1
Journal Article
in
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
2018
Virulent pseudorabies virus infection induces a specific and lethal systemic inflammatory response in mice
Kathlyn Laval
J. B. Vernejoul
Jolien Van Cleemput
O. O. Koyuncu
L. W. Enquist
A1
Journal Article
in
JOURNAL OF VIROLOGY
2018
2017
Access to a main alphaherpesvirus receptor, located basolaterally in the respiratory epithelium, is masked by intercellular junctions
Jolien Van Cleemput
Katrien Poelaert
Kathlyn Laval
Roger Maes
Gisela S Hussey
Wim Van Den Broeck
Hans Nauwynck
A1
Journal Article
in
SCIENTIFIC REPORTS
2017
Replication of neurovirulent equine herpesvirus type 1 (EHV-1) in CD172a+ monocytic cells
Kathlyn Laval
Jolien Van Cleemput
Katrien Poelaert
Ivy Brown
Hans Nauwynck
A1
Journal Article
in
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES
2017
2016
Dual infections of equine herpesvirus 1 and equine arteritis virus in equine respiratory mucosa explants
Jing Zhao
Haileleul Negussie Dubale
Kathlyn Laval
Katrien Poelaert
Hans Nauwynck
A1
Journal Article
in
VIRUS RESEARCH
2016
Entry of equid herpesvirus 1 into CD172a+ monocytic cells
Kathlyn Laval
Herman Favoreel
Jolien Van Cleemput
Katrien Poelaert
Ivy Brown
Bruno Verhasselt
Hans Nauwynck
A1
Journal Article
in
JOURNAL OF GENERAL VIROLOGY
2016
Equine CD172a+ monocytic cells, the 'Trojan horse' for equine herpesvirus type 1 (EHV-1) dissemination in the horse
Kathlyn Laval
Hans Nauwynck
Dissertation
2016
Pseudorabies virus US3 protein kinase protects infected cells from NK cell-mediated lysis via increased binding of the inhibitory NK cell receptor CD300a
Korneel Grauwet
M Vitale
Steffi De Pelsmaeker
Thary Jacob
Kathlyn Laval
L Moretta
M Parodi
S Parolini
C Cantoni
Herman Favoreel
A1
Journal Article
in
JOURNAL OF VIROLOGY
2016
2015
Equine herpesvirus type 1 enhances viral replication in CD172a⁺ monocytic cells upon adhesion to endothelial cells
Kathlyn Laval
Herman Favoreel
Katrien Poelaert
Jolien Van Cleemput
Hans Nauwynck
A1
Journal Article
in
JOURNAL OF VIROLOGY
2015
Equine herpesvirus type 1 replication is delayed in CD172a⁺ monocytic cells and controlled by histone deacetylases
Kathlyn Laval
Herman Favoreel
Hans Nauwynck
A1
Journal Article
in
JOURNAL OF GENERAL VIROLOGY
2015
2014
Isolation and characterization of equine nasal mucosal CD172a⁺ cells
Hossein Bannazadeh Baghi
Kathlyn Laval
Herman Favoreel
Hans Nauwynck
A1
Journal Article
in
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
2014
2012
Protein B5 is required on extracellular enveloped vaccinia virus for repulsion of superinfecting virions
Virginie Doceul
Michael Hollinshead
Adrien Breiman
Kathlyn Laval
Geoffrey L. Smith
A1
Journal Article
in
JOURNAL OF GENERAL VIROLOGY
2012