Research Explorer

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Researcher

Kathlyn Laval

Publications & Research Data

Awards & Distinctions

31 Results

2025

Genomic analysis and replication kinetics of the closely related EHV-1 neuropathogenic 21P40 and abortigenic 97P70 strains

Eslam MohamedInes ZarakNick VereeckeSebastiaan TheunsKathlyn LavalHans Nauwynck

A1 Journal Article in VETERINARY RESEARCH

Porcine hemagglutinating encephalomyelitis virus VW572 (not Gent/PS412 and Labadie) uses the CD81 receptor and MVB-derived exosomal pathway for efficient entry and spread in neuronal cells

Waqar ZaibCamille KavianiXixi KangYa GaoFreyja Vanden BrouckeW. Van den BroeckS. CoppensS. TheunsHans NauwynckKathlyn Laval

A1 Journal Article in JOURNAL OF VIROLOGY

2024

Aspergillus fumigatus spore proteases alter the respiratory mucosa architecture and facilitate equine herpesvirus 1 infection

Joren PortaelsEline Van CrombruggeWim Van Den BroeckKatrien LagrouKathlyn LavalHans Nauwynck

A1 Journal Article in VIRUSES-BASEL

The alphaherpesvirus gE/gI glycoprotein complex and proteases jointly orchestrate invasion across the host’s upper respiratory epithelial barrier

Eline Van CrombruggeXiaolei RenSarah GlorieuxInes ZarakWim Van Den BroeckClaus BachertNan ZhangThibaut Van ZeleD. KimG. A. Smith et al.

A1 Journal Article in MBIO

2023

Pseudorabies virus hijacks DDX3X, initiating an addictive 'mad itch' and immune suppression, to facilitate viral spread

Shane J. F. CroninMiguel A. TejadaRen SongKathlyn LavalDomagoj CikesMing JiAnnalaura BraiJohannes StadlmannMaria NovatchikovaThomas Perlot et al.

2022

Bacterial toxins from Staphylococcus aureus and Bordetella bronchiseptica predispose the horse’s respiratory tract to equine herpesvirus type 1 infection

Eline Van CrombruggeEmma VanbeylenJolien Van CleemputWim Van Den BroeckKathlyn LavalHans Nauwynck

A1 Journal Article in VIRUSES-BASEL

2021

CRISPR/Cas9-constructed pseudorabies virus mutants reveal the importance of UL13 in alphaherpesvirus escape from genome silencing

Jolien Van CleemputOrkide O. KoyuncuKathlyn LavalEsteban A. EngelLynn W. Enquist

A1 Journal Article in JOURNAL OF VIROLOGY

The pathogenesis and immune evasive mechanisms of equine herpesvirus type 1

Kathlyn LavalKatrien C. K. PoelaertJolien Van CleemputJing ZhaoAnnelies P. VandekerckhoveAnnick C. GryspeerdtBarbara GarréKaren van der MeulenHossein B. BaghiHaileleul N. Dubale et al.

A1 Journal Article in FRONTIERS IN MICROBIOLOGY

The potential role of herpes simplex virus type 1 and neuroinflammation in the pathogenesis of Alzheimer's disease

Kathlyn LavalLynn W. Enquist

A1 Journal Article in FRONTIERS IN NEUROLOGY

2020

An alphaherpesvirus exploits antimicrobial beta-defensins to initiate respiratory tract infection

Jolien Van CleemputKatrien PoelaertKathlyn LavalNathalie VanderheijdenMaarten DhaenensSimon DaledFilip BoyenFrank PasmansHans Nauwynck

A1 Journal Article in JOURNAL OF VIROLOGY

Mouse footpad inoculation model to study viral-induced neuroinflammatory responses

Kathlyn LavalCarola J. MaturanaLynn W. Enquist

A1 Journal Article in JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

The neuropathic itch caused by pseudorabies virus

Kathlyn LavalLynn W. Enquist

A1 Journal Article in PATHOGENS

2019

Alphaherpesvirus infection of mice primes PNS neurons to an inflammatory state regulated by TLR2 and type I IFN signaling

Kathlyn LavalJolien Van CleemputJonah VernejoulLynn Enquist

A1 Journal Article in PLOS PATHOGENS

Beyond gut instinct : metabolic short-chain fatty acids moderate the pathogenesis of alphaherpesviruses

Katrien PoelaertJolien Van CleemputKathlyn LavalSarah DescampsHerman FavoreelHans Nauwynck

A1 Journal Article in FRONTIERS IN MICROBIOLOGY

Deoxynivalenol, but not fumonisin B1, aflatoxin B1 or diesel exhaust particles disrupt integrity of the horse's respiratory epithelium and predispose it for equine herpesvirus type 1 infection

Jolien Van CleemputKatrien PoelaertKathlyn LavalWim Van Den BroeckHans Nauwynck

A1 Journal Article in VETERINARY MICROBIOLOGY

Equine herpesvirus 1 bridles T lymphocytes to reach its target organs

Katrien PoelaertJolien Van CleemputKathlyn LavalHerman FavoreelLiesbeth CouckWim Van Den BroeckWalid AzabHans Nauwynck

A1 Journal Article in JOURNAL OF VIROLOGY

Equine herpesvirus 1 infection orchestrates the expression of chemokines in equine respiratory epithelial cells

Katrien PoelaertJolien Van CleemputKathlyn LavalJiexiong XieHerman FavoreelHans Nauwynck

A1 Journal Article in JOURNAL OF GENERAL VIROLOGY

Pollens destroy respiratory epithelial cell anchors and drive alphaherpesvirus infection

Jolien Van CleemputKatrien PoelaertKathlyn LavalFrancis ImpensWim Van Den BroeckKris GevaertHans Nauwynck

A1 Journal Article in SCIENTIFIC REPORTS

Unravelling the first key steps in equine herpesvirus type 5 (EHV5) pathogenesis using ex vivo and in vitro equine models

Jolien Van CleemputKatrien PoelaertKathlyn LavalHans Nauwynck

A1 Journal Article in VETERINARY RESEARCH

2018

Abortigenic but not neurotropic equine herpes virus 1 modulates the interferon antiviral defense

Katrien PoelaertJolien Van CleemputKathlyn LavalHerman FavoreelGisela Soboll HusseyRoger K MaesHans Nauwynck

A1 Journal Article in FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY

Virulent pseudorabies virus infection induces a specific and lethal systemic inflammatory response in mice

Kathlyn LavalJ. B. VernejoulJolien Van CleemputO. O. KoyuncuL. W. Enquist

A1 Journal Article in JOURNAL OF VIROLOGY

2017

Access to a main alphaherpesvirus receptor, located basolaterally in the respiratory epithelium, is masked by intercellular junctions

Jolien Van CleemputKatrien PoelaertKathlyn LavalRoger MaesGisela S HusseyWim Van Den BroeckHans Nauwynck

A1 Journal Article in SCIENTIFIC REPORTS

Replication of neurovirulent equine herpesvirus type 1 (EHV-1) in CD172a+ monocytic cells

Kathlyn LavalJolien Van CleemputKatrien PoelaertIvy BrownHans Nauwynck

A1 Journal Article in COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES

2016

Dual infections of equine herpesvirus 1 and equine arteritis virus in equine respiratory mucosa explants

Jing ZhaoHaileleul Negussie DubaleKathlyn LavalKatrien PoelaertHans Nauwynck

A1 Journal Article in VIRUS RESEARCH

Entry of equid herpesvirus 1 into CD172a+ monocytic cells

Kathlyn LavalHerman FavoreelJolien Van CleemputKatrien PoelaertIvy BrownBruno VerhasseltHans Nauwynck

A1 Journal Article in JOURNAL OF GENERAL VIROLOGY

Equine CD172a+ monocytic cells, the 'Trojan horse' for equine herpesvirus type 1 (EHV-1) dissemination in the horse

Kathlyn LavalHans Nauwynck

Pseudorabies virus US3 protein kinase protects infected cells from NK cell-mediated lysis via increased binding of the inhibitory NK cell receptor CD300a

Korneel GrauwetM VitaleSteffi De PelsmaekerThary JacobKathlyn LavalL MorettaM ParodiS ParoliniC CantoniHerman Favoreel

A1 Journal Article in JOURNAL OF VIROLOGY

2015

Equine herpesvirus type 1 enhances viral replication in CD172a⁺ monocytic cells upon adhesion to endothelial cells

Kathlyn LavalHerman FavoreelKatrien PoelaertJolien Van CleemputHans Nauwynck

A1 Journal Article in JOURNAL OF VIROLOGY

Equine herpesvirus type 1 replication is delayed in CD172a⁺ monocytic cells and controlled by histone deacetylases

Kathlyn LavalHerman FavoreelHans Nauwynck

A1 Journal Article in JOURNAL OF GENERAL VIROLOGY

2014

Isolation and characterization of equine nasal mucosal CD172a⁺ cells

Hossein Bannazadeh BaghiKathlyn LavalHerman FavoreelHans Nauwynck

A1 Journal Article in VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

2012

Protein B5 is required on extracellular enveloped vaccinia virus for repulsion of superinfecting virions

Virginie DoceulMichael HollinsheadAdrien BreimanKathlyn LavalGeoffrey L. Smith

A1 Journal Article in JOURNAL OF GENERAL VIROLOGY