Research Explorer

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Researcher

Kathleen Van Craenenbroeck

Awards & Distinctions

59 Results

2019

Evaluating the applicability of mouse SINEs as an alternative normalization approach for RT-qPCR in brain tissue of the APP23 model for Alzheimer’s disease

Jana JanssensRené CransKathleen Van CraenenbroeckJo VandesompeleChristophe StoveDebby Van DamPeter P. De Deyn

A1 Journal Article in JOURNAL OF NEUROSCIENCE METHODS

The validation of Short Interspersed Nuclear Elements (SINEs) as a RT-qPCR normalization strategy in a rodent model for temporal lobe epilepsy

René CransJana JanssensSofie DaelemansElise WoutersRobrecht RaedtDebby Van DamPeter P De DeynKathleen Van CraenenbroeckChristophe Stove

A1 Journal Article in PLOS ONE

2018

Design, synthesis, and biological evaluation of bivalent ligands targeting dopamine D2-like receptors and the μ-opioid receptor

Mingcheng QianLakshmi VasudevanJelle HuysentruytMartijn RisseeuwChristophe StovePatrick ML VanderheydenKathleen Van CraenenbroeckSerge Van Calenbergh

A1 Journal Article in CHEMMEDCHEM

Molecular dissection of the human A3 adenosine receptor coupling with β-arrestin2

Jolien StormeAnnelies CannaertKathleen Van CraenenbroeckChristophe Stove

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Synthesis and biological evaluation of new bivalent GPCR ligands

Mingcheng QianSerge Van CalenberghKathleen Van Craenenbroeck

Synthesis toward bivalent ligands for the dopamine D2 and metabotropic glutamate 5 receptors

Mingcheng QianElise WoutersJames AR DaltonMartijn RisseeuwRené CransChristophe StoveJesús GiraldoKathleen Van CraenenbroeckSerge Van Calenbergh

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

2017

Regulation of G protein-coupled receptors by ubiquitination

Kamila SkieterskaPieter RondouKathleen Van Craenenbroeck

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2016

Characterization of Antibodies to Identify Cellular Expression of Dopamine Receptor 4

Janise D DemingKathleen Van CraenenbroeckYun Sung EomEun-Jin LeeCheryl Mae Craft

A1 Journal Article in Advances in Experimental Medicine and Biology

Characterization of the dopamine D4 receptor ubiquitination

Kamila SkieterskaKathleen Van Craenenbroeck

Characterization of the interaction between the dopamine D4 receptor, KLHL12 and β-arrestins

Kamila SkieterskaAo ShenDorien ClarissePieter RondouDasiel Oscar Borroto-EscuelaBéatrice LintermansKjell FuxeYang Kevin XiangKathleen Van Craenenbroeck

A1 Journal Article in CELLULAR SIGNALLING

Study of the cross-talk between the dopamine D2-like receptors and the μ opioid receptor

Mingcheng QianKathleen Van CraenenbroeckSerge Van Calenbergh

2015

Dopamine receptor D4 internalization requires a beta-arrestin and a visual arrestin

Janise D DemingJung-a ShinKayleen LimEun-Jin LeeKathleen Van CraenenbroeckCheryl Mae Craft

A1 Journal Article in CELLULAR SIGNALLING

Downregulation of 5-HT7 serotonin receptors by the atypical antipsychotics clozapine and olanzapine: role of motifs in the C-terminal domain and interaction with GASP-1

Omella ManfraKathleen Van CraenenbroeckKamila SkieterskaThomas FrimurerThue W SchwartzFinn Olav LevyKjetil Wessel Andressen

A1 Journal Article in ACS CHEMICAL NEUROSCIENCE

KLHL12 promotes non-lysine ubiquitination of the dopamine receptors D-4.2 and D-4.4, but not of the ADHD-associated D-4.7 variant

Kamila SkieterskaPieter RondouBéatrice LintermansKathleen Van Craenenbroeck

A1 Journal Article in PLOS ONE

2014

Dopamine D-4 receptor counteracts morphine-induced changes in µ opioid receptor signaling in the striosomes of the rat caudate putamen

Diana Suárez-BoomgaardBelén GagoAlejandra Valderrama-CarvajalRuth Roales-BujánKathleen Van CraenenbroeckJolien DuchouDasiel O Borroto-EscuelaJosé Medina-LuqueAdelaida de la CalleKjell Fuxe et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

How the venom from the ectoparasitoid wasp Nasonia vitripennis exhibits anti-inflammatory properties on mammalian cell lines

Ellen DanneelsSarah GerloKaren HeyninckKathleen Van CraenenbroeckKarolien De BosscherGuy HaegemanDirk de Graaf

A1 Journal Article in PLOS ONE

Non-degradative and non-lysine mediated ubiquitination of the dopamine D4 receptor

Kamila SkieterskaPieter RondouBéatrice LintermansKathleen Van Craenenbroeck

Phosphodiesterase 4 interacts with the 5-HT4(b) receptor to regulate cAMP signaling

Sabine WeningerKathleen Van CraenenbroeckRT CameronF VandeputMA MovsesianGS BaillieRomain Lefebvre

A1 Journal Article in CELLULAR SIGNALLING

Role of dimerization in dopamine D-4 receptor biogenesis

Kathleen Van CraenenbroeckDasiel O Borroto-EscuelaKamila SkieterskaJolien DuchouWilber Romero-FernandezKjell Fuxe

A1 Journal Article in CURRENT PROTEIN & PEPTIDE SCIENCE

The G protein-coupled receptor heterodimer network (GPCR-HetNet) and its hub components

Dasiel O Borroto-EscuelaIsmel BritoWilber Romero-FernandezMichael Di PalmaJulia OflijanKamila SkieterskaJolien DuchouKathleen Van CraenenbroeckDiana Suárez-BoomgaardAlicia Rivera et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The venom of Nasonia vitripennis : involvement in the host-parasitoid interaction and putative biomedical application

Ellen DanneelsDirk de GraafKathleen Van CraenenbroeckFranciscus Jacobs

2013

On the G-protein-coupled receptor heteromers and their allosteric receptor-receptor interactions in the central nervous system: focus on their role in pain modulation

Dasiel O Borroto-EscuelaWilber Romero-FernandezAlicia RiveraKathleen Van CraenenbroeckAlexander O TarakanovLuigi F AgnatiKjell Fuxe

A1 Journal Article in EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE

Role of non-degradative ubiquitination of the dopamine D4 receptor

Kamila SkieterskaPieter RondouDasiel O Borroto-EscuelaBéatrice LintermansKjell FuxeKathleen Van Craenenbroeck

The need for in vivo experiments to investigate possible chaperone effects of pharmacological compounds

Nick Van LaekenKathleen Van CraenenbroeckJeroen VerhoevenChristian VanhoveFilip De Vos

The serotonin 5-HT₇ receptors: two decades of research

Evelien GellynckKaren HeyninckKjetil W AndressenGuy HaegemanFinn Olav LevyPeter VanhoenackerKathleen Van Craenenbroeck

A1 Journal Article in EXPERIMENTAL BRAIN RESEARCH

2012

Biochemical and pharmacological study of N-linked glycosylation of the human serotonin 5-HT7(a) receptor

Evelien GellynckKjetil W AndressenBéatrice LintermansGuy HaegemanFinn O LevyPeter VanhoenackerKathleen Van Craenenbroeck

A1 Journal Article in FEBS JOURNAL

Functional relevance of the KLHL12-mediated D4 dopamine receptor ubiquitination

Kamila SkieterskaPieter RondouDasiel Oscar Borroto-EscuelaDorien ClarisseBéatrice LintermansGuy HaegemanKjell FuxeKathleen Van Craenenbroeck

GPCR oligomerization: contribution to receptor biogenesis

Kathleen Van Craenenbroeck

Bookchapter in GPCR signalling complexes : synthesis, assembly, trafficking and specificity

Importance of N- and C-terminus in localization and function of the 5-HT7 serotonin receptor

Evelien GellynckGuy HaegemanPeter VanhoenackerKathleen Van Craenenbroeck

On the track of function of KLHL12-mediated dopamine D4 receptor ubiquitination

Kamila SkieterskaPieter RondouDasiel Oscar Borroto-EscuelaDorien ClarisseBéatrice LintermansGuy HaegemanKjell FuxeKathleen Van Craenenbroeck

On the track of function of KLHL12-mediated dopamine D4 receptor ubiquitination

Kamila SkieterskaPieter RondouDasiel Oscar Borroto-EscuelaDorien ClarisseBéatrice LintermansGuy HaegemanKjell FuxeKathleen Van Craenenbroeck

RhoBTB3 interacts with the 5-HT7a receptor and inhibits its proteasomal degradation

Anne MatthysKathleen Van CraenenbroeckBéatrice LintermansGuy HaegemanPeter Van Hoenacker

A1 Journal Article in CELLULAR SIGNALLING

2011

Dopamine D-4 receptor oligomerization: contribution to receptor biogenesis

Kathleen Van CraenenbroeckDasiel O Borroto-EscuelaWilber Romero-FernandezKamila SkieterskaPieter RondouBéatrice LintermansPeter VanhoenackerKjell FuxeFrancisco CiruelaGuy Haegeman

A1 Journal Article in FEBS JOURNAL

Dopamine D2 and D4 receptor heteromerization and its allosteric receptor-receptor interactions

Dasiel O Borroto-EscuelaKathleen Van CraenenbroeckWilber Romero-FernandezDiego GuidolinAmina S WoodsAlicia RiveraGuy HaegemanLuigi F AgnatiAlexander O TarakanovKjell Fuxe

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Extracellular complexes of the hematopoietic human and mouse CSF-1 receptor are driven by common assembly principles

Jonathan ElegheertAmbroise DesfossesAlexander V ShkumatovXiongwu WuNathalie BrackeKenneth VerstraeteKathleen Van CraenenbroeckBernard R BrooksDmitri I SvergunBjorn Vergauwen et al.

A1 Journal Article in STRUCTURE

Inducible production of recombinant human Flt3 ectodomain variants in mammalian cells and preliminary crystallographic analysis of Flt3 ligand-receptor complexes

Kenneth VerstraeteBert RemmerieJonathan ElegheertBéatrice LintermansGuy HaegemanPeter VanhoenackerKathleen Van CraenenbroeckSavvas Savvides

A1 Journal Article in ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS

Role of the 5-HT7 receptor in the central nervous system : from current status to future perspectives

Anne MatthysGuy HaegemanKathleen Van CraenenbroeckPeter Vanhoenacker

A1 Journal Article in MOLECULAR NEUROBIOLOGY

Structural insights into the extracellular assembly of the hematopoietic Flt3 signaling complex

Kenneth VerstraeteGonzalez VandriesscheMariska JanuarJonathan ElegheertAlexander V ShkumatovAmbroise DesfossesKathleen Van CraenenbroeckDmitri I SvergunIrina GutscheBjorn Vergauwen et al.

A1 Journal Article in BLOOD

2010

Cooperation of NF kappa B and CREB to induce synergistic IL-6 expression in astrocytes

Anneleen SpoorenRon KooijmanBéatrice LintermansKathleen Van CraenenbroeckLinda VermeulenGuy HaegemanSarah Gerlo

A1 Journal Article in CELLULAR SIGNALLING

KLHL12-mediated ubiquitination of the dopamine D4 receptor does not target the receptor for degradation

Pieter RondouKamila SkieterskaAnn PackeuBéatrice LintermansPeter VanhoenackerGeorges VauquelinGuy HaegemanKathleen Van Craenenbroeck

A1 Journal Article in CELLULAR SIGNALLING

Resistance of the dopamine D4 receptor to agonist-induced internalization and degradation

Anneleen SpoorenPieter RondouKatarzyna DebowskaBéatrice LintermansLinda VermeulenBart SamynKamila SkieterskaGriet DebyserBart DevreesePeter Vanhoenacker et al.

A1 Journal Article in CELLULAR SIGNALLING

The HAC1 gene from Pichia pastoris: characterization and effect of its overexpression on the production of secreted, surface displayed and membrane proteins

Mouna GuerfalStefan RyckaertPieter JacobsPaul AmelootKathleen Van CraenenbroeckRiet De RyckeNico Callewaert

A1 Journal Article in MICROBIAL CELL FACTORIES

The dopamine D4 receptor: biochemical and signalling properties

Pieter RondouGuy HaegemanKathleen Van Craenenbroeck

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

2009

Cooperation of NF-κB and CREB to induce synergistic IL-6 transcription upon combined triggering of β2-adrenergic and TNF-receptors in astrocytes

Anneleen SpoorenRon KooijmanKathleen Van CraenenbroeckLinda VermeulenGuy HaegemanSarah Gerlo

The astrocytic β2-adrenergic receptor : a novel target for treatment of neuro-inflammation?

Sarah GerloAnneleen SpoorenRon KooijmanBéatrice LintermansKathleen Van CraenenbroeckGuy Haegeman

2008

BTB protein KLHL12 targets the dopamine D4 receptor for ubiquitination by a Cul3-based E3 ligase

Pieter RondouGuy HaegemanPeter VanhoenackerKathleen Van Craenenbroeck

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Cloning, genomic organization and functionality of 5-HT7 receptor splice variants from mouse brain

Evelien GellynckKoen LAENENKW ANDRESSENBéatrice LintermansKim De MartelaereAnne MatthysFO LEVYGuy HaegemanPeter VanhoenackerKathleen Van Craenenbroeck

A1 Journal Article in GENE

Selective transrepression versus transactivation mechanisms by glucocorticoid receptor modulators in stress and immune systems

Karolien De BosscherKathleen Van CraenenbroeckOnno C. MeijerGuy Haegeman

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACOLOGY

2006

Influence of the antipsychotic drug pipamperone on the expression of the dopamine D4 receptor

Kathleen Van CraenenbroeckEvelien GellynckBéatrice LintermansJE LEYSENHHM VAN TOLGuy HaegemanPeter Vanhoenacker

A1 Journal Article in LIFE SCIENCES

2005

Folding efficiency is rate-limiting in dopamine D4 receptor biogenesis

Kathleen Van CraenenbroeckSD CLARKMJ COXJN OAKF LIUHHM VAN TOL

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Role of glucocorticoids in dopamine-related neuropsychiatric disorders

Kathleen Van CraenenbroeckKarolien De BosscherWim Vanden BerghePeter VanhoenackerGuy Haegeman

A1 Journal Article in MOLECULAR AND CELLULAR ENDOCRINOLOGY

2003

DNA viral vectors in gene therapy

Kathleen Van CraenenbroeckPeter VanhoenackerGuy Haegeman

Bookchapter in Nature Encyclopedia of the human genome

Orientation-dependent gene expression with Epstein-Barr virus-derived vectors

Kathleen Van CraenenbroeckPeter VanhoenackerInge RomanGuy Haegeman

A1 Journal Article in FEBS LETTERS

2001

Evaluation of the tetracycline- and ecdysone-inducible systems for expression of neurotransmitter receptors in mammalian cells.

Kathleen Van CraenenbroeckPeter VanhoenackerJE LEYSENGuy Haegeman

A1 Journal Article in EUROPEAN JOURNAL OF NEUROSCIENCE

2000

Episomal vectors for gene expression in mammalian cells.

Kathleen Van CraenenbroeckPeter VanhoenackerGuy Haegeman

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

High-level expression of neurotransmitter receptors: Comparison of the usefulness of four different inducible expression systems

Peter VanhoenackerKathleen Van CraenenbroeckJ LEYSENGuy Haegeman

Molecular integrity and usefulness of episomal expression vectors derived from BK and Epstein-Barr virus.

Kathleen Van CraenenbroeckPeter VanhoenackerHilde DUCHAUGuy Haegeman

A1 Journal Article in GENE

Onderzoek van induceerbare systemen voor heterologe genexpressie in zoogdiercellen

Kathleen Van CraenenbroeckGuy Haegeman

1995

A reinvestigation of the covalent structure of Pseudomonas aeruginosa cytochrome c peroxidase.

Bart SamynKathleen Van CraenenbroeckLina De SmetIsabel VandenbergheG PETTIGREWJozef Van Beeumen

A1 Journal Article in FEBS LETTERS