Research Explorer

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Researcher

Karl Vergote

10 Results

2019

IL-33trap is a novel IL-33-neutralizing biologic that inhibits allergic airway inflammation

Aurora Holgado MunozHarald BraunElien Van NuffelSammy DetryMartijn SchuijsKim DeswarteKarl VergoteMira HaegmanGriet BaudeletJurgen HaustraeteHamida HammadBart LambrechtSavvas SavvidesInna AfoninaRudi Beyaert

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The ORMDL3 asthma susceptibility gene regulates systemic ceramide levels without altering key asthma features in mice

Nincy DebeufAssem ZhakupovaRegula SteinerSofie Van GassenKim DeswarteFarzaneh FayazpourJustine Van MoorleghemKarl VergoteBenjamin PavieKelly LemeireHamida HammadThorsten HornemannSophie JanssensBart Lambrecht

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF

Jessica VettersMary van HeldenSigrid WahlenSimon TavernierArne MartensFarzaneh FayazpourKarl VergoteManon VanheerswynghelsKim DeswarteJustine Van MoorleghemSofie De PrijckNozomi TakahashiPeter VandenabeeleLouis BoonGeert van LooEric VivierBart LambrechtSophie Janssens

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

2018

A bispecific antibody strategy to target multiple type 2 cytokines in asthma

Marie GodarKim DeswarteKarl VergoteMichael SaundersHans de HaardHamida HammadChristophe BlanchetotBart Lambrecht

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

2017

Regulated IRE1-dependent mRNA decay sets the threshold for dendritic cell survival

Simon TavernierFabiola OsorioLana VandersarrenJessica VettersNele VanlangenakkerGert Van IsterdaelKarl VergoteRiet De RyckeEef ParthoensLianne van de LaarTakao IwawakiJuan R Del ValleChih-Chi Andrew HuBart LambrechtSophie Janssens

A1 Journal Article in NATURE CELL BIOLOGY

Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10

Hamida HammadMatthias VanderkerkenPhilippe PouliotKim DeswarteWendy ToussaintKarl VergoteLana VandersarrenSophie JanssensIoanna RamouSavvas SavvidesJody HaighRudi HendriksManfred KopfKatleen CraessaertsBart de StrooperJohn F KearneyDaniel H ConradBart Lambrecht

A1 Journal Article in NATURE IMMUNOLOGY

2016

Cholesterol-sensing liver X receptors stimulate Th2-driven allergic eosinophilic asthma in mice

Muriel SmetLien Van HoeckeAns De BeuckelaerSeppe Vander BekenThomas NaessensKarl VergoteMonique WillartBart LambrechtJan-Ake GustafssonKnut R SteffensenJohan Grooten

A2 Journal Article in IMMUNITY INFLAMMATION AND DISEASE

IRF8 transcription factor controls survival and function of terminally differentiated conventional and plasmacytoid dendritic cells, respectively

Dorine SichienCharlotte ScottLiesbet MartensMatthias VanderkerkenSofie Van GassenMaud PlantingaThorsten JoerisSofie De PrijckLeen VanhoutteManon VanheerswynghelsGert Van IsterdaelWendy ToussaintFilipe Branco MadeiraKarl VergoteWilliam W AgaceBjörn E ClausenHamida HammadMarc DalodYvan SaeysBart LambrechtMartin Guilliams

A1 Journal Article in IMMUNITY

2015

Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells

Martijn SchuijsMonique WillartKarl VergoteDelphine GrasKim DeswarteMarkus J EgeFilipe Branco MadeiraRudi BeyaertGeert van LooFranz BracherErika von MutiusPascal ChanezBart LambrechtHamida Hammad

A1 Journal Article in SCIENCE

2014

Lung tumours reprogram pulmonary dendritic cell immunogenicity at the microRNA level

Lotte PyfferoenPieter MestdaghKarl VergoteNancy De CabooterJo VandesompeleBart LambrechtKarim Vermaelen

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER