Research Explorer

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Researcher

Karen Mollet

Awards & Distinctions

31 Results

2019

Reactivity of 3-oxo-β-lactams with respect to primary amines

Sari DeketelaereNicola PiensHannelore GoossensDietmar HertsenLieselotte CrulLotte DemeurisseJelle De MoorElias Van Den BroeckKaren MolletKristof Van Hecke et al.

Reactivity of 3-oxo-β-lactams with respect to primary amines

Sari DeketelaereNicola PiensHannelore GoossensDietmar HertsenLieselotte CrulLotte DemeurisseJelle De MoorElias Van Den BroeckKaren MolletKristof Van Hecke et al.

2017

Reactivity of 3-oxo-β-lactams with respect to primary amines : an experimental and computational approach

Nicola PiensHannelore GoossensDietmar HertsenSari DeketelaereLieselotte CrulLotte DemeurisseJelle De MoorElias Van Den BroeckKaren MolletKristof Van Hecke et al.

A1 Journal Article in CHEMISTRY-A EUROPEAN JOURNAL

2016

A nitrilase-mediated entry to 4-carboxymethyl-β-lactams from chemically prepared 4-(cyanomethyl)azetidin-2-ones

Lena DecuyperNicola PiensJens MinckeJeroen BomonBert De SchrijverKaren MolletKarel De WinterTom DesmetMatthias D'hooghe

A1 Journal Article in RSC ADVANCES

Diastereoselective synthesis of 3-acetoxy-4-(3-aryloxiran-2-yl)azetidin-2-ones and their transformation into 3,4-fused bicyclic β-lactams

Nicola PiensSven De CraeneKaren MolletKristof Van HeckeMatthias D'hooghe

Diastereoselective synthesis of 3-acetoxy-4-(3-aryloxiran-2-yl)azetidin-2-ones and their transformation into 3,4-oxolane-fused bicyclic β-lactams

Nicola PiensSven De CraeneJorick FranceusKaren MolletKristof Van HeckeTom DesmetMatthias D'hooghe

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Integrating biocatalytical processes into organic synthesis: nitrilase-mediated conversion of 2-aryl-3-(2-cyanoethyl)aziridines and 4-(cyanomethyl)azetidin-2-ones as a sustainable entry to functionalized γ-lactams and β-lactams

Nicola PiensLena DecuyperSaskia Vander MeerenJens MinckeJeroen BomonBert De SchrijverKaren MolletKarel De WinterTom DesmetMatthias D'hooghe

Synthesis and chemical/enzymatic hydrolysis of 2-aryl-3-(2-cyanoethyl)aziridines and 4-(cyanomethyl)azetidin-2-ones

Lena DecuyperNicola PiensSaskia Vander MeerenJens MinckeJeroen BomonBert De SchrijverKaren MolletKarel De WinterTom DesmetMatthias D'hooghe

Synthesis of novel trifluoromethylated azetidines, aminopropanes, 1,3-oxazinanes, and 1,3-oxazinan-2-ones starting from 4-trifluoromethyl-β-lactam building blocks

Hang Dao ThiLena DecuyperKaren MolletSara KennisNorbert De KimpeTuyen Nguyen VanMatthias D'hooghe

Synthesis of trifluoromethylated azetidines, aminopropanes, 1,3-oxazinanes, and 1,3-oxazinan-2-ones starting from 4-trifluoromethyl-β-lactam building blocks

Hang Dao ThiLena DecuyperKaren MolletSara KenisNorbert De KimpeTuyen Van NguyenMatthias D'hooghe

A1 Journal Article in SYNLETT

2015

Expedient stereoselective synthesis of new dihydropyrano- and dihydrofuranonaphthoquinones

Tuyet Anh Dang ThiYves DepetterKaren MolletHoang Thi PhuongDoan Vu NgocChinh Pham TheHa Thanh NguyenThu Ha Nguyen ThiHung Huy NguyenMatthias D'hooghe et al.

A1 Journal Article in TETRAHEDRON LETTERS

Synthesis of 2-aryl-3-(2-cyanoethyl)aziridines and their chemical and enzymatic hydrolysis towards γ-lactams and γ-lactones

Karen MolletLena DecuyperSaskia Vander MeerenNicola PiensKarel De WinterTom DesmetMatthias D'hooghe

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

2014

Reactivity of aziridinium salts in different solvents unraveled by a combined theoretical and experimental approach

Hannelore GoossensDietmar HertsenKaren MolletSaron CatakMatthias D'hoogheFrank De ProftPaul GeerlingsNorbert De KimpeMichel WaroquierVeronique Van Speybroeck

Bookchapter in Structure, bonding and reactivity of heterocyclic compounds

Synthesis of 2-aryl-3-(2-cyanoethyl)aziridines and their chemical and enzymatic hydrolysis towards γ-lactams and γ-lactones

Lena DecuyperKaren MolletSaskia Vander MeerenNicola PiensKarel De WinterTom DesmetMatthias D'hooghe

Synthesis of 2-hydroxy-1,4-oxazin-3-ones through ring transformation of 3-hydroxy-4-(1,2-dihydroxyethyl)-β-lactams and study of their reactivity

Nicola PiensKaren MolletHannelore GoossensSaron CatakMichel WaroquierKarl W. TörnroosVeronique Van SpeybroeckNorbert De KimpeMatthias D'hooghe

Synthesis of trifluoromethylated azetidines, aminopropanes, 1,3-oxazinanes, and 1,3-oxazinan-2-ones starting from 4-trifluoromethyl-β-lactam building blocks

Hang Dao ThiLena DecuyperKaren MolletSara KennisNorbert De KimpeTuyen Nguyen VanMatthias D'hooghe

2013

Application of functionalized β-lactams for the selective construction of new aza- and oxaheterocyclic systems

Karen MolletNorbert De KimpeMatthias D'hooghe

Computational rationalization of the ring transformation of 3-hydroxy-4-(1,2-dihydroxyethyl)-β-lactams

Hannelore GoossensSaron CatakKaren MolletNicola PiensMatthias D'hoogheNorbert De KimpeMichel WaroquierVeronique Van Speybroeck

Epihalohydrins in organic synthesis

Girija S SinghKaren MolletMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in CHEMICAL REVIEWS

Synthesis of 2-hydroxy-1,4-oxazin-3-ones through ring transformation of 3-hydroxy-4-(1,2-dihydroxyethyl)-β-lactams and a study of their reactivity

Karen MolletHannelore GoossensNicola PiensSaron CatakMichel WaroquierKarl W TornroosVeronique Van SpeybroeckMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of 2-hydroxy-1,4-oxazin-3-ones through ring transformation of 3-hydroxy-4-(1,2-dihydroxyethyl)-β-lactams and study of their reactivity

Nicola PiensKaren MolletHannelore GoossensSaron CatakMichel WaroquierKarl W. TörnroosVeronique Van SpeybroeckNorbert De KimpeMatthias D'hooghe

Synthesis of piperidin-4-ones starting from 2-(2-bromo-1,1-dimethylethyl)-azetidines and 2-(2-mesyloxyethyl)azetidines through a ring expansion-oxidation protocol

Karen MolletMatthias D'hoogheLeen BroeckxBarbara DanneelsTom DesmetNorbert De Kimpe

A1 Journal Article in TETRAHEDRON

Synthesis of six-membered azaheterocycles by means of the β-lactam synthon method

Karen MolletMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in MINI-REVIEWS IN ORGANIC CHEMISTRY

2012

Design, synthesis and antiviral evaluation of purine-β-lactam and purine-aminopropanol hybrids

Matthias D'hoogheKaren MolletRob De VreeseTim JonckersGéry DamsNorbert De Kimpe

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Stereoselective synthesis of bicyclic tetrahydrofuran-fused β-lactams and their conversion into methyl cis-3-aminotetrahydrofuran-2-carboxylates

Karen MolletMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in TETRAHEDRON

Synthesis of stereodefined 3,4-disubstituted piperidines through rearrangement of 2-(2-bromo-1,1-dimethylethyl)azetidines

Karen MolletLeen BroeckxMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in HETEROCYCLES

2011

Stereoselective synthesis of cis-3,4-disubstituted piperidines through ring transformation of 2-(2-mesyloxyethyl)azetidines

Karen MolletSaron CatakMichel WaroquierVeronique Van SpeybroeckMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Synthesis of 2-amino-3-arylpropan-1-ols and 1-(2,3-diaminopropyl)-1,2,3-triazoles and evaluation of their antimalarial activity

Matthias D'hoogheStephanie VandekerckhoveKaren MolletKarel VervischStijn DekeukeleireLiesbeth LehoucqCarmen LateganPeter J SmithKelly ChibaleNorbert De Kimpe

A1 Journal Article in BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY

Transformation of trans-4-aryl-3-chloro-1-(2-chloroethyl)azetidin-2-ones into 3-aryl-2-(ethylamino)propan-1-ols via intermediate 1-(1-aryl-2-chloro-3-hydroxypropyl)aziridines and trans-2-aryl-3-(hydroxymethyl)aziridines

Karen MolletMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

2010

Stereoselective synthesis of trans- and cis-2-aryl-3-(hydroxymethyl)aziridines through transformation of 4-aryl-3-chloro-β-lactams and study of their ring opening

Matthias D'hoogheKaren MolletStijn DekeukeleireNorbert De Kimpe

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

2009

Synthesis of novel 2-alkoxy-3-amino-3-arylpropan-1-ols and 5-alkoxy-4-aryl-1,3-oxazinanes with antimalarial activity

Matthias D'hoogheStijn DekeukeleireKaren MolletCarmen LateganPeter SmithKelly ChibaleNorbert De Kimpe

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY