Research Explorer

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Researcher

Karen Heyninck

52 Results

2018

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma

Behrouz HassanniaBartosz WiernickiIrina IngoldFeng QuSimon Van HerckYulia Y. TyurinaHülya BayırBehnaz A. AbhariJose Pedro Friedmann AngeliSze Men ChoiEline MeulKaren HeyninckKen DeclerckChandra Sekhar ChirumamillaMaija Lahtela-KakkonenGuy Van CampDmitri KryskoPaul G. EkertSimone FuldaBruno De GeestMarcus ConradValerian KaganWim Vanden BerghePeter VandenabeeleTom Vanden Berghe

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

2014

Cancer chemoprevention by dietary polyphenols

Karen HeyninckGuy HaegemanAjay Goel

Bookchapter in Polyphenols in human health and disease

Dietary flavanols modulate the transcription of genes associated with cardiovascular pathology without changes in their DNA methylation state

Dragan MilenkovicWim Vanden BergheCéline BobyChristine LerouxKen DeclerckKatarzyna Szarc vel SzicKaren HeyninckKris LaukensMartin BizetMatthieu DefranceSarah DedeurwaerderEmilie CalonneFrançois FuksGuy HaegemanGuido RMM HaenenAalt BastAntje R Weseler

A1 Journal Article in PLOS ONE

Ectopic microRNA-150-5p transcription sensitizes glucocorticoid therapy response in MM1S multiple myeloma cells but fails to overcome hormone therapy resistance in MM1R cells

Ajay PalaganiKen Op de BeeckStefan NaulaertsJolien DiddensChandra Sekhar ChirumamillaGuy Van CampKris LaukensKaren HeyninckSarah GerloPieter MestdaghJo VandesompeleWim Vanden Berghe

A1 Journal Article in PLOS ONE

How the venom from the ectoparasitoid wasp Nasonia vitripennis exhibits anti-inflammatory properties on mammalian cell lines

Ellen DanneelsSarah GerloKaren HeyninckKathleen Van CraenenbroeckKarolien De BosscherGuy HaegemanDirk de Graaf

A1 Journal Article in PLOS ONE

Immunomodulatory effects of 17-O-acetylacuminolide in RAW264.7 cells and HUVECs : involvement of MAPK and NF-κB pathways

Mouna AchouiKaren HeyninckChung Yeng LooiAli Mohd MustafaGuy HaegemanMohd Rais Mustafa

A1 Journal Article in DRUG DESIGN DEVELOPMENT AND THERAPY

Pharmacological levels of withaferin A (Withania somnifera) trigger clinically relevant anticancer effects specific to triple negative breast cancer cells

Katarzyna Szarc vel SzicKen Op De BeeckDariusz RatmanAn WoutersIlse BeckKen DeclerckKaren HeyninckErik FransenMarc BrackeKarolien De BosscherFilip LardonGuy Van CampWim Vanden Berghe

A1 Journal Article in PLOS ONE

Withaferin A inhibits NF-kappaB activation by targeting cysteine 179 in IKKβ

Karen HeyninckMaija Lahtela-KakkonenPieter Van der VekenGuy HaegemanWim Vanden Berghe

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

2013

Modulation of Nrf2-KEAP1 signaling by the natural compound Withaferin A: potential therapeutic effect in cardiovascular diseases?

Linde SabbeWim Vanden BergheKaren HeyninckGuy Haegeman

The role of serine- and metalloproteases in Nasonia vitripennis venom in cell death related processes towards a Spodoptera frugiperda Sf21 cell line

Ellen FormesynKaren HeyninckDirk de Graaf

A1 Journal Article in JOURNAL OF INSECT PHYSIOLOGY

The serotonin 5-HT₇ receptors: two decades of research

Evelien GellynckKaren HeyninckKjetil W AndressenGuy HaegemanFinn Olav LevyPeter VanhoenackerKathleen Van Craenenbroeck

A1 Journal Article in EXPERIMENTAL BRAIN RESEARCH

2012

Flavanols modulate the transcription of genes involved in cardiovascular pathology with heterogenic changes of their DNA methylation state: FLAVIOLA associated

Antje R WeselerDragan MilenkovicWim Vanden BergheErik JB RuijtersKaren HeyninckFrançois FuksGuy HaegemanGuido RMM HaenenAalt Bast

Flavanols: what do we know about their mechanisms of action?

Aalt BastSylvain ClaudeGuy HaegemanGuido RMM HaenenChristian HeissKaren HeyninckMarc MerxDragan MilenkovicChristine MorandErik JB RuijtersWim Vanden BergheAntje Weseler

Molecular insight in the multifunctional activities of Withaferin A

Wim Vanden BergheLinde SabbeMary KailehGuy HaegemanKaren Heyninck

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

2011

Phytochemicals and cancer chemoprevention: epigenetic friends or foe?

Katarzina Szarc vel SzicAjay PalaganiBehrouz HassanniaLinde SabbeKaren HeyninckGuy HaegemanWim Vanden Berghe

Bookchapter in Phytochemicals : bioactivities and impact on health

2008

ABINs inhibit EGF receptor-mediated NF-kappa B activation and growth of EGF receptor-overexpressing tumour cells

Lieven HuangLynn VerstrepenKaren HeyninckAndy WullaertH REVETSP DE BAETSELIERRudi Beyaert

A1 Journal Article in ONCOGENE

Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappa B activation

H IHAJM PELOPONESELynn VerstrepenG ZAPARTF IKEDACD SMITHMF STAROSTV YEDAVALLIKaren HeyninckI DIKICRudi BeyaertKT JEANG

A1 Journal Article in EMBO JOURNAL

T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappa B inhibitor A20

Beatrice CoornaertM BAENSKaren HeyninckTine BekaertMira HaegmanJens StaalLJ SUNZJJ CHENP MARYNENRudi Beyaert

A1 Journal Article in NATURE IMMUNOLOGY

2007

Hepatic tumor necrosis factor signaling and nuclear factor-kappa B: Effects on liver homeostasis and beyond

Andy WullaertGeert van LooKaren HeyninckRudi Beyaert

A1 Journal Article in ENDOCRINE REVIEWS

LIND/ABIN-3 is a novel lipopolysaccharide-inducible inhibitor of NF-kappa B activation

Andy WullaertLynn VerstrepenSofie Van HuffelM Adib-ConquySigrid CornelisMarja KreikeMira HaegmanKarim El BakkouriMatthew SandersKelly VerhelstIsabelle CarpentierJM CavaillonKaren HeyninckRudi Beyaert

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2006

A novel link between Lck, Bak expression and chemosensitivity

Karen HeyninckRudi Beyaert

Editorial material

Karen HeyninckRudi Beyaert

A4 Journal Article in Nature Molecule Pages

Karen HeyninckRudi Beyaert

A4 Journal Article in Nature Molecule Pages

Mechanisms of crosstalk between TNF-induced NF-kappa B and JNK activation in hepatocytes

Andy WullaertKaren HeyninckRudi Beyaert

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

TNF alpha- and IKK beta-mediated TANK/I-TRAF phosphorylation: implications for interaction with NEMO/IKK gamma and NF-kappa B activation

M BONIFMA MEUWISP CLOSEV BENOITKaren HeyninckJP CHAPELLEV BOURSMP MERVILLEJ PIETTERudi BeyaertA CHARIOT

A1 Journal Article in BIOCHEMICAL JOURNAL

Ubiquitin: tool and target for intracellular NF-κB inhibitors

Andy WullaertKaren HeyninckSophie JanssensRudi Beyaert

A1 Journal Article in TRENDS IN IMMUNOLOGY

2005

A20 inhibits NF-κB activation by dual ubiquitin-editing functions

Karen HeyninckRudi Beyaert

A1 Journal Article in TRENDS IN BIOCHEMICAL SCIENCES

Adenoviral gene transfer of ABIN-1 protects mice from TNF/galactosamine-induced acute liver failure and lethality

Andy WullaertBen WielockxSofie Van HuffelVeerle BogaertB DE GEESTP PAPELEUPeter SchotteKarim El BakkouriKaren HeyninckClaude LibertRudi Beyaert

A1 Journal Article in HEPATOLOGY

Adenoviral gene transfer of the NF-kappa B inhibitory protein ABIN-1 decreases allergic airway inflammation in a murine asthma model

Karim El BakkouriAndy WullaertMira HaegmanKaren HeyninckRudi Beyaert

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2004

The yeast three-hybrid system as a tool to study caspases

Wim Van CriekingePeter SchotteKaren HeyninckRudi Beyaert

Bookchapter in Apoptosis methods and protocols

Yeast two-hybrid screening for proteins interacting with the anti-apoptotic protein A20

Karen HeyninckSofie Van HuffelMarja KreikeRudi Beyaert

Bookchapter in Apoptosis methods and protocols

2003

A novel type of deubiquitinating enzyme*

PC EVANSTS SMITHMJ LAIMG WILLIAMSDF BURKEKaren HeyninckMarja KreikeRudi BeyaertTL BLUNDELLPJ KILSHAW

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

NF-κB activation by tumor necrosis factor and interleukin-1

Isabelle CarpentierSophie JanssensKaren HeyninckRudi Beyaert

Bookchapter in Nuclear factor κB : regulation and role in disease

Nuclear factor-kappa B plays a central role in tumour necrosis factor-mediated liver disease

Karen HeyninckAndy WullaertRudi Beyaert

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Structure-function analysis of the A20-binding inhibitor of NF-kappa B activation, ABIN-1

Karen HeyninckMarja KreikeRudi Beyaert

A1 Journal Article in FEBS LETTERS

2002

Signaling to gene activation and cell death by tumor necrosis factor receptors and Fas

Rudi BeyaertGeert van LooKaren HeyninckPeter Vandenabeele

A1 Journal Article in International Review of Cytology : a Survey of Cell Biology

2001

Crosstalk between NF-êB-activating and apoptosis-inducing proteins of the TNF-receptor complex

Karen HeyninckRudi Beyaert

A2 Journal Article in MOLECULAR CELL BIOLOGY RESEARCH COMMUNICATIONS

Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappa B activation and protein-protein interactions.

Marco KlinkenbergSofie Van HuffelKaren HeyninckRudi Beyaert

A1 Journal Article in FEBS LETTERS

Identification of a novel A20-binding inhibitor of nuclear factor-kappa B activation termed ABIN-2.

Sofie Van HuffelFilip DelaeiKaren HeyninckDirk De ValckRudi Beyaert

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Isolation and characterization of two novel A20-like proteins.

PC EVANSER TAYLORJ COADWELLKaren HeyninckRudi BeyaertPJ KILSHAW

A1 Journal Article in BIOCHEMICAL JOURNAL

2000

A20 and A20-binding proteins as cellular inhibitors of nuclear factor-kappa B-dependent gene expression and apoptosis.

Rudi BeyaertKaren HeyninckSofie Van Huffel

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

1999

Identificatie en karakterisering van cellulaire inhibitoren van NF-kB-afhankelijke genexpressie

Karen HeyninckR. ContrerasR. Beyaert

Inhibition of Tumor Necrosis Factor-induced necrotic cell death by the zinc finger protein A20.

Karen HeyninckGeertrui DeneckerDirk De ValckWalter FiersRudi Beyaert

A1 Journal Article in ANTICANCER RESEARCH

The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappa B activation at the level of TRAF6.

Karen HeyninckRudi Beyaert

A1 Journal Article in FEBS LETTERS

The zinc finger protein A20 inhibits TNF-induced NF-kappa B-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappa B-inhibiting protein ABIN.

Karen HeyninckDirk De ValckWim Vanden BergheWim Van CriekingeRoland ContrerasWalter FiersGuy HaegemanRudi Beyaert

A1 Journal Article in JOURNAL OF CELL BIOLOGY

The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases.

Dirk De ValckDY JINKaren HeyninckMarc Van De CraenRoland ContrerasWalter FiersKT JEANGRudi Beyaert

A1 Journal Article in ONCOGENE

1997

A20 inhibits NF-kappa B activation independently of binding to 14-3-3 proteins.

Dirk De ValckKaren HeyninckWim Van CriekingePeter VandenabeeleWalter FiersRudi Beyaert

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tumour necrosis factor: intracellular mechanism of action

Walter FiersRudi BeyaertElke BooneWim DeclercqEls DecosterDirk De ValckVera GoossensJohan GrootenGuy HaegemanKaren HeyninckL PenningS PlaisanceMarc Van De CraenPeter VandenabeeleWim Vanden BergheVeronique VandevoordeDominique Vercammen

Bookchapter in HIV and cytokines

1996

A20, an inhibitor of cell death, self-associates by its zinc finger domain.

Dirk De ValckKaren HeyninckWim Van CriekingeRoland ContrerasRudi BeyaertWalter Fiers

A1 Journal Article in FEBS LETTERS

TNF-induced intracellular signaling leading to gene induction or to cytotoxicity by necrosis or by apoptosis.

Walter FiersRudi BeyaertElke BooneSigrid CornelisWim DeclercqEls DecosterGeertrui DeneckerBart DepuydtDirk De ValckG DEWILDEVera GoossensJohan GrootenGuy HaegemanKaren HeyninckL PENNINGS PLAISANCEKatia VancompernolleWim Van CriekingePeter VandenabeeleW VANDENBERGHEMarc Van De CraenVeronique VandevoordeDominique Vercammen

A1 Journal Article in JOURNAL OF INFLAMMATION

1993

ENHANCEMENT OF TUMOR-NECROSIS-FACTOR CYTOTOXICITY BY LITHIUM-CHLORIDE IS ASSOCIATED WITH INCREASED INOSITOL PHOSPHATE ACCUMULATION.

Rudi BeyaertKaren HeyninckDirk De ValckF BOEYKENSFrans Van RoyWalter Fiers

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Sensitization of tumor cells to tumor necrosis factor action by the protein kinase inhibitor staurosporine

Rudi BeyaertBart VanhaesebroeckKaren HeyninckElke BooneDirk De ValckKlaus Schulze-OsthoffGuy HaegemanFrans Van RoyWalter Fiers

A1 Journal Article in CANCER RESEARCH