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Researcher
Karen Heyninck
Profile
Projects
Publications
Activities
Awards & Distinctions
52
Results
2018
Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma
Behrouz Hassannia
Bartosz Wiernicki
Irina Ingold
Feng Qu
Simon Van Herck
Yulia Y. Tyurina
Hülya Bayır
Behnaz A. Abhari
Jose Pedro Friedmann Angeli
Sze Men Choi
et al.
A1
Journal Article
in
JOURNAL OF CLINICAL INVESTIGATION
2018
2014
Cancer chemoprevention by dietary polyphenols
Karen Heyninck
Guy Haegeman
Ajay Goel
Bookchapter
in
Polyphenols in human health and disease
2014
Dietary flavanols modulate the transcription of genes associated with cardiovascular pathology without changes in their DNA methylation state
Dragan Milenkovic
Wim Vanden Berghe
Céline Boby
Christine Leroux
Ken Declerck
Katarzyna Szarc vel Szic
Karen Heyninck
Kris Laukens
Martin Bizet
Matthieu Defrance
et al.
A1
Journal Article
in
PLOS ONE
2014
Ectopic microRNA-150-5p transcription sensitizes glucocorticoid therapy response in MM1S multiple myeloma cells but fails to overcome hormone therapy resistance in MM1R cells
Ajay Palagani
Ken Op de Beeck
Stefan Naulaerts
Jolien Diddens
Chandra Sekhar Chirumamilla
Guy Van Camp
Kris Laukens
Karen Heyninck
Sarah Gerlo
Pieter Mestdagh
et al.
A1
Journal Article
in
PLOS ONE
2014
How the venom from the ectoparasitoid wasp Nasonia vitripennis exhibits anti-inflammatory properties on mammalian cell lines
Ellen Danneels
Sarah Gerlo
Karen Heyninck
Kathleen Van Craenenbroeck
Karolien De Bosscher
Guy Haegeman
Dirk de Graaf
A1
Journal Article
in
PLOS ONE
2014
Immunomodulatory effects of 17-O-acetylacuminolide in RAW264.7 cells and HUVECs : involvement of MAPK and NF-κB pathways
Mouna Achoui
Karen Heyninck
Chung Yeng Looi
Ali Mohd Mustafa
Guy Haegeman
Mohd Rais Mustafa
A1
Journal Article
in
DRUG DESIGN DEVELOPMENT AND THERAPY
2014
Pharmacological levels of withaferin A (Withania somnifera) trigger clinically relevant anticancer effects specific to triple negative breast cancer cells
Katarzyna Szarc vel Szic
Ken Op De Beeck
Dariusz Ratman
An Wouters
Ilse Beck
Ken Declerck
Karen Heyninck
Erik Fransen
Marc Bracke
Karolien De Bosscher
et al.
A1
Journal Article
in
PLOS ONE
2014
Withaferin A inhibits NF-kappaB activation by targeting cysteine 179 in IKKβ
Karen Heyninck
Maija Lahtela-Kakkonen
Pieter Van der Veken
Guy Haegeman
Wim Vanden Berghe
A1
Journal Article
in
BIOCHEMICAL PHARMACOLOGY
2014
2013
Modulation of Nrf2-KEAP1 signaling by the natural compound Withaferin A: potential therapeutic effect in cardiovascular diseases?
Linde Sabbe
Wim Vanden Berghe
Karen Heyninck
Guy Haegeman
Dissertation
2013
The role of serine- and metalloproteases in Nasonia vitripennis venom in cell death related processes towards a Spodoptera frugiperda Sf21 cell line
Ellen Formesyn
Karen Heyninck
Dirk de Graaf
A1
Journal Article
in
JOURNAL OF INSECT PHYSIOLOGY
2013
The serotonin 5-HT₇ receptors: two decades of research
Evelien Gellynck
Karen Heyninck
Kjetil W Andressen
Guy Haegeman
Finn Olav Levy
Peter Vanhoenacker
Kathleen Van Craenenbroeck
A1
Journal Article
in
EXPERIMENTAL BRAIN RESEARCH
2013
2012
Flavanols modulate the transcription of genes involved in cardiovascular pathology with heterogenic changes of their DNA methylation state: FLAVIOLA associated
Antje R Weseler
Dragan Milenkovic
Wim Vanden Berghe
Erik JB Ruijters
Karen Heyninck
François Fuks
Guy Haegeman
Guido RMM Haenen
Aalt Bast
C3
Conference
2012
Flavanols: what do we know about their mechanisms of action?
Aalt Bast
Sylvain Claude
Guy Haegeman
Guido RMM Haenen
Christian Heiss
Karen Heyninck
Marc Merx
Dragan Milenkovic
Christine Morand
Erik JB Ruijters
et al.
C3
Conference
2012
Molecular insight in the multifunctional activities of Withaferin A
Wim Vanden Berghe
Linde Sabbe
Mary Kaileh
Guy Haegeman
Karen Heyninck
A1
Journal Article
in
BIOCHEMICAL PHARMACOLOGY
2012
2011
Phytochemicals and cancer chemoprevention: epigenetic friends or foe?
Katarzina Szarc vel Szic
Ajay Palagani
Behrouz Hassannia
Linde Sabbe
Karen Heyninck
Guy Haegeman
Wim Vanden Berghe
Bookchapter
in
Phytochemicals : bioactivities and impact on health
2011
2008
ABINs inhibit EGF receptor-mediated NF-kappa B activation and growth of EGF receptor-overexpressing tumour cells
Lieven Huang
Lynn Verstrepen
Karen Heyninck
Andy Wullaert
H REVETS
P DE BAETSELIER
Rudi Beyaert
A1
Journal Article
in
ONCOGENE
2008
Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappa B activation
H IHA
JM PELOPONESE
Lynn Verstrepen
G ZAPART
F IKEDA
CD SMITH
MF STAROST
V YEDAVALLI
Karen Heyninck
I DIKIC
et al.
A1
Journal Article
in
EMBO JOURNAL
2008
T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappa B inhibitor A20
Beatrice Coornaert
M BAENS
Karen Heyninck
Tine Bekaert
Mira Haegman
Jens Staal
LJ SUN
ZJJ CHEN
P MARYNEN
Rudi Beyaert
A1
Journal Article
in
NATURE IMMUNOLOGY
2008
2007
Hepatic tumor necrosis factor signaling and nuclear factor-kappa B: Effects on liver homeostasis and beyond
Andy Wullaert
Geert van Loo
Karen Heyninck
Rudi Beyaert
A1
Journal Article
in
ENDOCRINE REVIEWS
2007
LIND/ABIN-3 is a novel lipopolysaccharide-inducible inhibitor of NF-kappa B activation
Andy Wullaert
Lynn Verstrepen
Sofie Van Huffel
M Adib-Conquy
Sigrid Cornelis
Marja Kreike
Mira Haegman
Karim El Bakkouri
Matthew Sanders
Kelly Verhelst
et al.
A1
Journal Article
in
JOURNAL OF BIOLOGICAL CHEMISTRY
2007
2006
A novel link between Lck, Bak expression and chemosensitivity
Karen Heyninck
Rudi Beyaert
Editorial material
2006
Abin1
Karen Heyninck
Rudi Beyaert
A4
Journal Article
in
Nature Molecule Pages
2006
Abin2
Karen Heyninck
Rudi Beyaert
A4
Journal Article
in
Nature Molecule Pages
2006
Mechanisms of crosstalk between TNF-induced NF-kappa B and JNK activation in hepatocytes
Andy Wullaert
Karen Heyninck
Rudi Beyaert
A1
Journal Article
in
BIOCHEMICAL PHARMACOLOGY
2006
TNF alpha- and IKK beta-mediated TANK/I-TRAF phosphorylation: implications for interaction with NEMO/IKK gamma and NF-kappa B activation
M BONIF
MA MEUWIS
P CLOSE
V BENOIT
Karen Heyninck
JP CHAPELLE
V BOURS
MP MERVILLE
J PIETTE
Rudi Beyaert
et al.
A1
Journal Article
in
BIOCHEMICAL JOURNAL
2006
Ubiquitin: tool and target for intracellular NF-κB inhibitors
Andy Wullaert
Karen Heyninck
Sophie Janssens
Rudi Beyaert
A1
Journal Article
in
TRENDS IN IMMUNOLOGY
2006
2005
A20 inhibits NF-κB activation by dual ubiquitin-editing functions
Karen Heyninck
Rudi Beyaert
A1
Journal Article
in
TRENDS IN BIOCHEMICAL SCIENCES
2005
Adenoviral gene transfer of ABIN-1 protects mice from TNF/galactosamine-induced acute liver failure and lethality
Andy Wullaert
Ben Wielockx
Sofie Van Huffel
Veerle Bogaert
B DE GEEST
P PAPELEU
Peter Schotte
Karim El Bakkouri
Karen Heyninck
Claude Libert
et al.
A1
Journal Article
in
HEPATOLOGY
2005
Adenoviral gene transfer of the NF-kappa B inhibitory protein ABIN-1 decreases allergic airway inflammation in a murine asthma model
Karim El Bakkouri
Andy Wullaert
Mira Haegman
Karen Heyninck
Rudi Beyaert
A1
Journal Article
in
JOURNAL OF BIOLOGICAL CHEMISTRY
2005
2004
The yeast three-hybrid system as a tool to study caspases
Wim Van Criekinge
Peter Schotte
Karen Heyninck
Rudi Beyaert
Bookchapter
in
Apoptosis methods and protocols
2004
Yeast two-hybrid screening for proteins interacting with the anti-apoptotic protein A20
Karen Heyninck
Sofie Van Huffel
Marja Kreike
Rudi Beyaert
Bookchapter
in
Apoptosis methods and protocols
2004
2003
A novel type of deubiquitinating enzyme*
PC EVANS
TS SMITH
MJ LAI
MG WILLIAMS
DF BURKE
Karen Heyninck
Marja Kreike
Rudi Beyaert
TL BLUNDELL
PJ KILSHAW
A1
Journal Article
in
JOURNAL OF BIOLOGICAL CHEMISTRY
2003
NF-κB activation by tumor necrosis factor and interleukin-1
Isabelle Carpentier
Sophie Janssens
Karen Heyninck
Rudi Beyaert
Bookchapter
in
Nuclear factor κB : regulation and role in disease
2003
Nuclear factor-kappa B plays a central role in tumour necrosis factor-mediated liver disease
Karen Heyninck
Andy Wullaert
Rudi Beyaert
A1
Journal Article
in
BIOCHEMICAL PHARMACOLOGY
2003
Structure-function analysis of the A20-binding inhibitor of NF-kappa B activation, ABIN-1
Karen Heyninck
Marja Kreike
Rudi Beyaert
A1
Journal Article
in
FEBS LETTERS
2003
2002
Signaling to gene activation and cell death by tumor necrosis factor receptors and Fas
Rudi Beyaert
Geert van Loo
Karen Heyninck
Peter Vandenabeele
A1
Journal Article
in
International Review of Cytology : a Survey of Cell Biology
2002
2001
Crosstalk between NF-êB-activating and apoptosis-inducing proteins of the TNF-receptor complex
Karen Heyninck
Rudi Beyaert
A2
Journal Article
in
MOLECULAR CELL BIOLOGY RESEARCH COMMUNICATIONS
2001
Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappa B activation and protein-protein interactions.
Marco Klinkenberg
Sofie Van Huffel
Karen Heyninck
Rudi Beyaert
A1
Journal Article
in
FEBS LETTERS
2001
Identification of a novel A20-binding inhibitor of nuclear factor-kappa B activation termed ABIN-2.
Sofie Van Huffel
Filip Delaei
Karen Heyninck
Dirk De Valck
Rudi Beyaert
A1
Journal Article
in
JOURNAL OF BIOLOGICAL CHEMISTRY
2001
Isolation and characterization of two novel A20-like proteins.
PC EVANS
ER TAYLOR
J COADWELL
Karen Heyninck
Rudi Beyaert
PJ KILSHAW
A1
Journal Article
in
BIOCHEMICAL JOURNAL
2001
2000
A20 and A20-binding proteins as cellular inhibitors of nuclear factor-kappa B-dependent gene expression and apoptosis.
Rudi Beyaert
Karen Heyninck
Sofie Van Huffel
A1
Journal Article
in
BIOCHEMICAL PHARMACOLOGY
2000
1999
Identificatie en karakterisering van cellulaire inhibitoren van NF-kB-afhankelijke genexpressie
Karen Heyninck
Roland Contreras
Rudi Beyaert
Dissertation
1999
Inhibition of Tumor Necrosis Factor-induced necrotic cell death by the zinc finger protein A20.
Karen Heyninck
Geertrui Denecker
Dirk De Valck
Walther Fiers
Rudi Beyaert
A1
Journal Article
in
ANTICANCER RESEARCH
1999
The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappa B activation at the level of TRAF6.
Karen Heyninck
Rudi Beyaert
A1
Journal Article
in
FEBS LETTERS
1999
The zinc finger protein A20 inhibits TNF-induced NF-kappa B-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappa B-inhibiting protein ABIN.
Karen Heyninck
Dirk De Valck
Wim Vanden Berghe
Wim Van Criekinge
Roland Contreras
Walther Fiers
Guy Haegeman
Rudi Beyaert
A1
Journal Article
in
JOURNAL OF CELL BIOLOGY
1999
The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases.
Dirk De Valck
DY JIN
Karen Heyninck
Marc Van De Craen
Roland Contreras
Walther Fiers
KT JEANG
Rudi Beyaert
A1
Journal Article
in
ONCOGENE
1999
1997
A20 inhibits NF-kappa B activation independently of binding to 14-3-3 proteins.
Dirk De Valck
Karen Heyninck
Wim Van Criekinge
Peter Vandenabeele
Walther Fiers
Rudi Beyaert
A1
Journal Article
in
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
1997
Tumour necrosis factor: intracellular mechanism of action
Walther Fiers
Rudi Beyaert
Elke Boone
Wim Declercq
Els Decoster
Dirk De Valck
Vera Goossens
Johan Grooten
Guy Haegeman
Karen Heyninck
et al.
Bookchapter
in
HIV and cytokines
1997
1996
A20, an inhibitor of cell death, self-associates by its zinc finger domain.
Dirk De Valck
Karen Heyninck
Wim Van Criekinge
Roland Contreras
Rudi Beyaert
Walther Fiers
A1
Journal Article
in
FEBS LETTERS
1996
TNF-induced intracellular signaling leading to gene induction or to cytotoxicity by necrosis or by apoptosis.
Walther Fiers
Rudi Beyaert
Elke Boone
Sigrid Cornelis
Wim Declercq
Els Decoster
Geertrui Denecker
Bart Depuydt
Dirk De Valck
G DEWILDE
et al.
A1
Journal Article
in
JOURNAL OF INFLAMMATION
1996
1993
ENHANCEMENT OF TUMOR-NECROSIS-FACTOR CYTOTOXICITY BY LITHIUM-CHLORIDE IS ASSOCIATED WITH INCREASED INOSITOL PHOSPHATE ACCUMULATION.
Rudi Beyaert
Karen Heyninck
Dirk De Valck
F BOEYKENS
Frans Van Roy
Walther Fiers
A1
Journal Article
in
JOURNAL OF IMMUNOLOGY
1993
Sensitization of tumor cells to tumor necrosis factor action by the protein kinase inhibitor staurosporine
Rudi Beyaert
Bart Vanhaesebroeck
Karen Heyninck
Elke Boone
Dirk De Valck
Klaus Schulze-Osthoff
Guy Haegeman
Frans Van Roy
Walther Fiers
A1
Journal Article
in
CANCER RESEARCH
1993