Research Explorer

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Researcher

Karel Vervisch

Awards & Distinctions

12 Results

2016

LiAlH4-Induced selective ring rearrangement of 2-(2-cyanoethyl)aziridines toward 2-(aminomethyl)pyrrolidines and 3-aminopiperidines as eligible heterocyclic building blocks

Jeroen DolfenKarel VervischNorbert De KimpeMatthias D'hooghe

A1 Journal Article in CHEMISTRY-A EUROPEAN JOURNAL

2013

Synthesis of 2-aminomethyl-4-phenyl-1-azabicyclo[2.2.1]heptanes via LiAlH4-induced reductive cyclization of 2-(4-chloro-2-cyano-2-phenylbutyl) aziridines and evaluation of their antimalarial activity

Matthias D'hoogheKarel VervischKarl W TörnroosTom VerhaegheTom DesmetCarmen LateganPeter J SmithKelly ChibaleNorbert De Kimpe

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

2012

Chemical and enzymatic synthesis of 2-(2-carbamoylethyl)- and 2-(2-carboxyethyl)aziridines and their conversion into δ-lactams and γ-lactones

Karel VervischMatthias D'hoogheFloris PJT RutjesNorbert De Kimpe

A1 Journal Article in ORGANIC LETTERS

Radical-mediated nitrile translocation as the key step in the stereoselective transformation of 2-(4-chloro-2-cyanobutyl)aziridines to methyl cis-(1-arylmethyl-4-phenylpiperidin-2-yl)acetates

Karel VervischMatthias D'hoogheKarl W TörnroosNorbert De Kimpe

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

2011

Reactivity of activated versus nonactivated 2-(bromomethyl)aziridines with respect to sodium methoxide: a combined computational and experimental study

Hannelore GoossensKarel VervischSaron CatakSonja StankovićMatthias D'hoogheFrank De ProftPaul GeerlingsNorbert De KimpeMichel WaroquierVeronique Van Speybroeck

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Synthesis of 2-(2-cyanoeyhyl)aziridines and their transformation into a variety of novel cyclic amino nitriles

Karel VervischNorbert De KimpeMatthias D'hooghe

Synthesis of 2-(aminomethyl)aziridines and their microwave-assisted ring opening to 1,2,3-triaminopropanes as novel antimalarial pharmacophores

Matthias D'hoogheSara KenisKarel VervischCarmen LateganPeter SmithKelly ChibaleNorbert De Kimpe

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of 2-amino-3-arylpropan-1-ols and 1-(2,3-diaminopropyl)-1,2,3-triazoles and evaluation of their antimalarial activity

Matthias D'hoogheStephanie VandekerckhoveKaren MolletKarel VervischStijn DekeukeleireLiesbeth LehoucqCarmen LateganPeter J SmithKelly ChibaleNorbert De Kimpe

A1 Journal Article in BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY

2010

Synthesis of stereodefined piperidines from aziridines and their transformation into conformationally constrained amino acids, amino alcohols and 2,7-diazabicyclo[3.3.1]nonanes

Karel VervischMatthias D'hoogheKarl TörnroosNorbert De Kimpe

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

2009

A new approach towards 1-phenyl and 1-benzyl substituted 2-(aminomethyl)cyclopropanecarboxamides as novel derivatives of the antidepressant Milnacipran

Karel VervischMatthias D'hoogheKarl TörnroosNorbert De Kimpe

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

2007

Ring opening of 2-(cyanomethyl)aziridines by acid chlorides: synthesis of novel 4-amino-2-butenenitrile derivatives through intermediate aziridinium salts

Matthias D'hoogheKarel VervischAndries Van NieuwenhoveNorbert De Kimpe

A1 Journal Article in TETRAHEDRON LETTERS

Synthesis of 1-arylmethyl-2-(2-cyanoethyl)aziridines and their rearrangement into novel 2-(Aminomethyl)cyclopropanecarbonitriles

Matthias D'hoogheKarel VervischNorbert De Kimpe

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY