Research Explorer

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Researcher

Justine Van Moorleghem

Publications & Research Data

Awards & Distinctions

18 Results

2026

Cross-species cellular mapping and humanization of Fcγ receptors to advance antibody modeling

Karel Van DammeDorine SichienKatrien Van Der BorghtJustine Van MoorleghemSofie Van GassenJoseph JorssenSeppe De WinterElisabeth De LeeuwCaihong WangQingqing Chai et al.

A1 Journal Article in SCIENCE IMMUNOLOGY

TNFAIP3/A20 dysfunction drives innate and sterile hyperinflammation

Karel Van DammePieter HertensDorine SichienKatrien Van Der BorghtJustine Van MoorleghemSofie De PrijckAlex KLarenbeekEls LouagieInés LammensStijn Vanhee et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

2024

IL-2 family cytokines IL-9 and IL-21 differentially regulate innate and adaptive type 2 immunity in asthma

Fabian BickClaudia Mariela Brenis GómezInés LammensJustine Van MoorleghemCaroline De WolfSam DupontLaure DumoutierNeal P. SmithAlexandra-Chloé VillaniRobin Browaeys et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Interleukin-33-activated basophils promote asthma by regulating Th2 cell entry into lung tissue

Martijn SchuijsClaudia Mariela Brenis GómezFabian BickJustine Van MoorleghemManon VanheerswynghelsGeert van LooRudi BeyaertDavid VoehringerRichard M. LocksleyHamida Hammad et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

2023

Canonical IRE1 function needed to sustain vigorous natural killer cell proliferation during viral infection

Jessica VettersMary van HeldenClint De NolfSofie RennenEva ClootsEvelien Van De VeldeFarzaneh FayazpourJustine Van MoorleghemManon VanheerswynghelsKarl Vergote et al.

A1 Journal Article in ISCIENCE

STE20 kinase TAOK3 regulates type 2 immunity and metabolism in obesity

Bastiaan MaesFarzaneh FayazpourLeen CatrysseGuillaume LornetEvelien Van De VeldeCaroline De WolfSofie De PrijckJustine Van MoorleghemManon VanheerswynghelsKim Deswarte et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

2022

The STE20 kinase TAOK3 controls the development of house dust mite-induced asthma in mice

Bastiaan MaesUrsula SmoleMatthias VanderkerkenKim DeswarteJustine Van MoorleghemKarl VergoteManon VanheerswynghelsCaroline De WolfSofie De PrijckNincy Debeuf et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

2021

CCR2-and Flt3-dependent inflammatory conventional type 2 dendritic cells are necessary for the induction of adaptive immunity by the human vaccine adjuvant system AS01

Cedric BosteelsKaat FierensSofie De PrijckJustine Van MoorleghemManon VanheerswynghelsCaroline De WolfAurelie ChalonCatherine CollignonHamida HammadArnaud M. Didierlaurent et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

2019

Prophylactic allergen immunotherapy with Der p 2 prevents murine asthma by regulating lung GM-CSF

Eline HaspeslaghManon VanheerswynghelsKim DeswarteJustine Van MoorleghemAlain JacquetBart LambrechtHamida Hammad

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The ORMDL3 asthma susceptibility gene regulates systemic ceramide levels without altering key asthma features in mice

Nincy DebeufAssem ZhakupovaRegula SteinerSofie Van GassenKim DeswarteFarzaneh FayazpourJustine Van MoorleghemKarl VergoteBenjamin PavieKelly Lemeire et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF

Jessica VettersMary van HeldenSigrid WahlenSimon TavernierArne MartensFarzaneh FayazpourKarl VergoteManon VanheerswynghelsKim DeswarteJustine Van Moorleghem et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

2018

Co-activation of glucocorticoid receptor and peroxisome proliferator-activated receptor-γ in murine skin prevents worsening of atopic march

Julie DeckersNadia BougarneViacheslav MylkaSofie DesmetAstrid LuypaertMichael DevosGiel TangheJustine Van MoorleghemManon VanheerswynghelsLode De Cauwer et al.

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

Role of NKp46⁺ natural killer cells in house dust mite-driven asthma

Eline HaspeslaghMary van HeldenKim DeswarteSofie De PrijckJustine Van MoorleghemLouis BoonHamida HammadEric VivierBart Lambrecht

A1 Journal Article in EMBO MOLECULAR MEDICINE

2017

Airway epithelial cells are crucial targets of glucocorticoids in a mouse model of allergic asthma

Carina KlassenAnna KarabinskayaLien DejagerSabine VettorazziJustine Van MoorleghemFred LuehderSebastiaan H MeijsingJan P TuckermannHanibal BohnenbergerClaude Libert et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Epicutaneous sensitization to house dust mite allergen requires interferon regulatory factor 4-dependent dermal dendritic cells

Julie DeckersDorine SichienMaud PlantingaJustine Van MoorleghemManon VanheerswynghelsEsther HosteBernard MalissenDavid DombrowiczMartin GuilliamsKarolien De Bosscher et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

House dust mite-driven asthma and allergen-specific T cells depend on B cells when the amount of inhaled allergen is limiting

Melissa DullaersMartijn SchuijsMonique WillartKaat FierensJustine Van MoorleghemHamida HammadBart Lambrecht

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Myocardial infarction primes autoreactive T cells through activation of dendritic cells

Katrien Van Der BorghtCharlotte ScottVeronika NindlAnn BouchéLiesbet MartensDorine SichienJustine Van MoorleghemManon VanheerswynghelsSofie De PrijckYvan Saeys et al.

A1 Journal Article in CELL REPORTS

2016

Perinatal activation of the interleukin-33 pathway promotes type 2 immunity in the developing lung

Ismé De KleerMirjam KoolMarjolein JW de BruijnMonique WillartJustine Van MoorleghemMartijn SchuijsMaud PlantingaRudi BeyaertEmily HamsPadraic G Fallon et al.

A1 Journal Article in IMMUNITY