Research Explorer

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Researcher

Jurgen Vercruysse

Awards & Distinctions

37 Results

2019

In-depth evaluation of data collected during a continuous pharmaceutical manufacturing process : a multivariate statistical process monitoring approach

Ana Filipa Costa da SilvaJurgen VercruysseChris VervaetJean Paul RemonJoão A. LopesThomas De BeerMafalda C. Sarraguça

A1 Journal Article in JOURNAL OF PHARMACEUTICAL SCIENCES

2018

Breakage and drying behaviour of granules in a continuous fluid bed dryer : influence of process parameters and wet granule transfer

Fien De LeersnyderValérie VanhoorneH BekaertJurgen VercruysseMichael GhijsNils BostijnMaxim VerstraetenP CappuynsI Van AsscheY Vander Heyden et al.

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Process monitoring and evaluation of a continuous pharmaceutical twin-screw granulation and drying process using multivariate data analysis

Antonio Pires da Silva BaptistaJurgen VercruysseChris VervaetJean Paul RemonJ.A. LopesThomas De BeerM.C. Sarraguça

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

2017

Continuous direct compression as manufacturing platform for sustained release tablets

Bernd Van SnickJ. HolmanC. CunninghamAshish KumarJurgen VercruysseThomas De BeerJean Paul RemonChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Multivariate statistical process control of a continuous pharmaceutical twin-screw granulation and fluid bed drying process

Ana Tavares da SilvaMC SarraguçaMargot FonteyneJurgen VercruysseFien De LeersnyderValérie VanhoorneNils BostijnMaxim VerstraetenChris VervaetJean Paul Remon et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

2016

Assessment and prediction of tablet properties using transmission and backscattering Raman spectroscopy and transmission NIR spectroscopy

Elisabeth PeetersAna Tavares da SilvaMaunu ToiviainenJeroen Van RenterghemJurgen VercruysseMikko JuutiJoao Almeida LopesThomas De BeerChris VervaetJean Paul Remon

A1 Journal Article in ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES

Blend uniformity evaluation during continuous mixing in a twin screw granulator by in-line NIR using a moving F-test

Margot FonteyneJurgen VercruysseFien De LeersnyderRut BesselingAd GerichWim OostraJean Paul RemonChris VervaetThomas De Beer

A1 Journal Article in ANALYTICA CHIMICA ACTA

Development of a process map : a step towards a regime map for steady-state high shear wet twin screw granulation

Ashish KumarJens DhondtJurgen VercruysseFien De LeersnyderValérie VanhoorneChris VervaetJean Paul RemonKrist V. GernaeyThomas De BeerIngmar Nopens

A1 Journal Article in POWDER TECHNOLOGY

Linking granulation performance with residence time and granulation liquid distributions in twin-screw granulation : an experimental investigation

Ashish KumarMaija AlakarjulaValérie VanhoorneMaunu ToiviainenFien De LeersnyderJurgen VercruysseMikko JuutiJarkko KetolainenChris VervaetJean Paul Remon et al.

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Model-based analysis of a twin-screw wet granulation system for continuous solid dosage manufacturing

Ashish KumarJurgen VercruysseSéverine MortierChris VervaetJean Paul RemonKrist V GernaeyThomas De BeerIngmar Nopens

A1 Journal Article in COMPUTERS & CHEMICAL ENGINEERING

Model-based process analysis in continuous manufacturing of pharmaceuticals : calibration of a fluid bed dryer model

Michael GhijsFien De LeersnyderDaan Van HauwermeirenValérie VanhoorneJurgen VercruyssePhilippe CappuynsSéverine MortierThomas De BeerKrist GernaeyIngmar Nopens

2015

Analysis of a twin-screw granulation process using a combined experimental and computational approach

Ashish KumarJurgen VercruysseKrist V GernaeyThomas De BeerIngmar Nopens

Combined experimental and computational approach to elucidate the twin-screw granulation process

Ashish KumarJurgen VercruysseChris VervaetJean Paul RemonKrist V GernaeyThomas De BeerIngmar Nopens

Conceptual framework for model-based analysis of residence time distribution in twin-screw granulation

Ashish KumarJurgen VercruysseValérie VanhoorneMaunu ToiviainenPierre-Emmanuel PanouillotMikko JuutiChris VervaetJean Paul RemonKrist V GernaeyThomas De Beer et al.

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Development of regime map for steady-state high shear wet twin-screw granulation

Ashish KumarJens DhondtJurgen VercruysseFien De LeersnyderValérie VanhoorneKrist V GernaeyThomas De BeerIngmar Nopens

Evaluation of an in-line particle imaging tool for monitoring twin-screw granulation performance

Ashish KumarJens DhondtFien De LeersnyderJurgen VercruysseValérie VanhoorneChris VervaetJean Paul RemonKrist V GernaeyThomas De BeerIngmar Nopens

A1 Journal Article in POWDER TECHNOLOGY

Impact of screw configuration on the particle size distribution of granules produced by twin screw granulation

Jurgen VercruysseAnneleen BurggraeveMargot FonteyneP CappuynsU DelaetI Van AsscheThomas De BeerJean Paul RemonChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Process analytical technology for continuous manufacturing of solid-dosage forms

Margot FonteyneJurgen VercruysseFien De LeersnyderBernd Van SnickChris VervaetJean Paul RemonThomas De Beer

A1 Journal Article in TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Use of a continuous twin screw granulation and drying system during formulation development and process optimization

Jurgen VercruysseElisabeth PeetersMargot FonteyneP CappuynsU DelaetI Van AsscheThomas De BeerJean Paul RemonChris Vervaet

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

2014

Distribution of binder in granules produced by means of twin screw granulation

Margot FonteyneAndrew Luke FussellJurgen VercruysseChris VervaetJean Paul RemonClare StrachanThomas RadesThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Experimental investigation of granule shape and size dynamics in twin-screw granulation

Ashish KumarJurgen VercruysseKrist V GernaeyThomas De BeerIngmar Nopens

Experimental investigation of granule size and shape dynamics in twin-screw granulation

Ashish KumarJurgen VercruysseGiacomo BellandiKrist V GernaeyChris VervaetJean Paul RemonThomas De BeerIngmar Nopens

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Experimental investigation of residence time distribution in twin-screw granulation

Ashish KumarJurgen VercruysseMaunu ToiviainenPierre-Emmanuel PanouillotMikko JuutiValérie VanhoorneKrist V GernaeyThomas De BeerIngmar Nopens

Influence of raw material properties upon critical quality attributes of continuously produced granules and tablets

Margot FonteyneHenrika WickströmElisabeth PeetersJurgen VercruysseHenrik EhlersBjörn-Hendrik PetersJean Paul RemonChris VervaetJarkko KetolainenNiklas Sandler et al.

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Innovation in pharmaceutical manufacturing of solid dosage forms via continuous wet granulation

Jurgen VercruysseChris VervaetJean Paul Remon

Mixing and transport during pharmaceutical twin-screw wet granulation : experimental analysis via chemical imaging

Ashish KumarJurgen VercruysseMaunu ToiviainenPierre-Emmanuel PanouillotMikko JuutiValérie VanhoorneChris VervaetJean Paul RemonKrist V GernaeyThomas De Beer et al.

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Model-based analysis and experimental validation of residence time distribution in twin-screw granulation

Ashish KumarJurgen VercruysseMaunu ToiviainenPierre-Emmanuel PanouillotMikko JuutiValérie VanhoorneKrist V GernaeyThomas De BeerIngmar Nopens

Moisture and drug solid-state monitoring during a continuous drying process using empirical and mass balance models

Margot FonteyneDelphine GildemynElisabeth PeetersSéverine MortierJurgen VercruysseKrist V GernaeyChris VervaetJean Paul RemonIngmar NopensThomas De Beer

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Visualization and understanding of the granulation liquid mixing and distribution during continuous twin screw granulation using NIR chemical imaging

Jurgen VercruysseMaunu ToiviainenMargot FonteyneNiko HelkimoJarkko KetolainenMikko JuutiUrbain DelaetIvo Van AsscheJean Paul RemonChris Vervaet et al.

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

2013

An experimental study on effect of screw configuration in twin screw wet granulation

Ashish KumarJurgen VercruysseKrist V GernaeyIngmar NopensThomas De Beer

Evaluation of particle shape and size evolution during high-shear wet granulatoin using twin-screw granulator

Ashish KumarJurgen VercruysseKrist V GernaeyThomas De BeerIngmar Nopens

Real-time assessment of critical quality attributes of a continuous granulation process

Margot FonteyneJurgen VercruysseDamián Córdoba DíazDelphine GildemynChris VervaetJean Paul RemonThomas De Beer

A1 Journal Article in PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY

Stability and repeatability of a continuous twin screw granulation and drying system

Jurgen VercruysseU DelaetI Van AsscheP CappuynsF ArataG CaporicciThomas De BeerJean Paul RemonChris Vervaet

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

2012

Continuous twin screw granulation: influence of process variables on granule and tablet quality

Jurgen VercruysseD Córdoba DíazElisabeth PeetersMargot FonteyneU DelaetI Van AsscheThomas De BeerJean Paul RemonChris Vervaet

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Mechanistic modelling of the drying behaviour of single pharmaceutical granules

Séverine MortierThomas De BeerKrist GernaeyJurgen VercruysseMargot FonteyneJean Paul RemonChris VervaetIngmar Nopens

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Prediction of quality attributes of continuously produced granules using complementary pat tools

Margot FonteyneSandra Liliana De Oliveira SoaresJurgen VercruysseElisabeth PeetersAnneleen BurggraeveChris VervaetJean Paul RemonNiklas SandlerThomas De Beer

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

2011

Modelling of drying processes of pharmaceutical granules

Séverine MortierSreepriya VedantamThomas De BeerKV GernaeyMargot FonteyneJurgen VercruysseJean Paul RemonChris VervaetIngmar Nopens