Research Explorer

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Researcher

Junhua Xie

Publications & Research Data

Awards & Distinctions

19 Results

2026

Systemic inflammation modulates clearance and drives extra-hepatic distribution of extracellular vesicles

Svetlana PavlovaDoste R. MamandAndre GorgensAntje M. ZicklerWenyi ZhengXiuming LiangOscar P. B. WiklanderManuchehr Abedi-ValugerdiElien Van WonterghemJunhua Xie et al.

A1 Journal Article in JOURNAL OF EXTRACELLULAR VESICLES

2025

Engineering of extracellular vesicles for efficient intracellular delivery of multimodal therapeutics including genome editors

Xiuming LiangDhanu GuptaJunhua XieElien Van WonterghemLien Van HoeckeJustin HeanZheyu NiuMarziyeh GhaeidaminiOscar P. B. WiklanderWenyi Zheng et al.

A1 Journal Article in NATURE COMMUNICATIONS

Gut microbiota modulates CNS barrier function in murine model for multiple sclerosis

Junhua XieMarlies BurgelmanPieter DujardinJonas CasteleinGriet Van ImschootElien Van WonterghemHannah LernoutSjoerd SchettersCharysse VandendriesscheLien Van Hoecke et al.

A1 Journal Article in FLUIDS AND BARRIERS OF THE CNS

The gut-brain axis in Alzheimer's disease is shaped by commensal gut microbiota derived extracellular vesicles

Junhua XieLien Van HoeckeElien Van WonterghemGriet Van ImschootVanessa AndriesLars VereeckeRoosmarijn Vandenbroucke

A1 Journal Article in GUT MICROBES

2024

An immunological puzzle : the adaptive immune system fuels Alzheimer’s disease pathology

Lien Van HoeckeJonas CasteleinJunhua XieLore Van AckerGriet Van ImschootElien Van WonterghemIne VlaeminckDaan VerhaegeWouter ClaeysKeimpe Wierda et al.

A1 Journal Article in BRAIN BEHAVIOR AND IMMUNITY

The phytohormone abscisic acid enhances remyelination in mouse models of multiple sclerosis

Femke Van GaeverFleur MingneauSam VanherleYasmine DriegeMira HaegmanElien Van WonterghemJunhua XieRoosmarijn VandenbrouckeJerome J. A. HendriksRudi Beyaert et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

The spreading and effects of human recombinant α-synuclein preformed fibrils in the cerebrospinal fluid of mice

Charysse VandendriesscheArnout BruggemanJoyce ForoozandehLien Van HoeckePieter DujardinJunhua XieGriet Van ImschootElien Van WonterghemJonas CasteleinCristiano Lucci et al.

A1 Journal Article in ENEURO

2023

Bacterial extracellular vesicles : an emerging avenue to tackle diseases

Junhua XieFreddy HaesebrouckLien Van HoeckeRoosmarijn Vandenbroucke

A1 Journal Article in TRENDS IN MICROBIOLOGY

Gut microbiota regulates blood-cerebrospinal fluid barrier function and Aβ pathology

Junhua XieArnout BruggemanClint De NolfCharysse VandendriesscheGriet Van ImschootElien Van WonterghemLars VereeckeRoosmarijn Vandenbroucke

A1 Journal Article in EMBO JOURNAL

Helicobacter pylori-derived outer membrane vesicles contribute to Alzheimer's disease pathogenesis via C3-C3aR signalling

Junhua XieLien CoolsGriet Van ImschootElien Van WonterghemMarie PauwelsIne VlaeminckChloë De WitteSamir EL AndaloussiKeimpe WierdaLies De Groef et al.

A1 Journal Article in JOURNAL OF EXTRACELLULAR VESICLES

2022

Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation

Lidia YshiiEmanuela PasciutoPascal BielefeldLoriana MascaliPierre LemaitreMarika MarinoJames DooleyLubna KouserStijn VerschorenVasiliki Lagou et al.

A1 Journal Article in NATURE IMMUNOLOGY

Choroid plexus-derived extracellular vesicles exhibit brain targeting characteristics

Marie PauwelsJunhua XieAdam CeroiSriram BalusuJonas CasteleinElien Van WonterghemGriet Van ImschootAndrew WardTrevelyan R. MenheniottOskar Gustafsson et al.

A1 Journal Article in BIOMATERIALS

Studying the impact of the gastrointestinal bacteria on the brain, focusing on the blood-cerebrospinal fluid barrier and Alzheimer's disease

Junhua XieRoosmarijn VandenbrouckeFreddy HaesebrouckLien Van Hoecke

The impact of systemic inflammation on Alzheimer's disease pathology

Junhua XieLien Van HoeckeRoosmarijn Vandenbroucke

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

The tremendous biomedical potential of bacterial extracellular vesicles

Junhua XieQiqiong LiFreddy HaesebrouckLien Van HoeckeRoosmarijn Vandenbroucke

A1 Journal Article in TRENDS IN BIOTECHNOLOGY

2021

Anti-inflammatory mesenchymal stromal cell-derived extracellular vesicles improve pathology in Niemann-Pick type C disease

Lien Van HoeckeCaroline Van CauwenbergheVerena BoergerArnout BruggemanJonas CasteleinGriet Van ImschootElien Van WonterghemRobin DittrichWouter ClaeysJunhua Xie et al.

A1 Journal Article in BIOMEDICINES

Gastric Helicobacter suis infection partially protects against neurotoxicity in A 6-OHDA Parkinson’s disease mouse model

Helena BerlamontArnout BruggemanEva BauwensCharysse VandendriesscheElien ClareboutJunhua XieSofie De BruyckereGriet Van ImschootElien Van WonterghemRichard Ducatelle et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Involvement of the choroid plexus in the pathogenesis of Niemann-Pick disease type C

Lien Van HoeckeCaroline Van CauwenbergheKristina DominkoGriet Van ImschootElien Van WonterghemJonas CasteleinJunhua XieWouter ClaeysCharysse VandendriesscheAnna Kremer et al.

A1 Journal Article in FRONTIERS IN CELLULAR NEUROSCIENCE

Low-grade peripheral inflammation affects brain pathology in the App(NL-G-F)mouse model of Alzheimer's disease

Junhua XieNina GorléCharysse VandendriesscheGriet Van ImschootElien Van WonterghemCaroline Van CauwenbergheEef ParthoensEvelien Van HammeSaskia LippensLien Van Hoecke et al.

A1 Journal Article in ACTA NEUROPATHOLOGICA COMMUNICATIONS