Research Explorer

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Researcher

Juan Fraire

31 Results

2023

Laser‐scanning microscopy for electrophoretic mobility characterization of single nanoparticles

Lucas OorlynckYera UssembayevIngrid Amer CidJuan FraireCharlotte HinnekensKevin BraeckmansFilip Strubbe

A1 Journal Article in PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION

2022

Fast laser scanning imaging for single nanoparticle analysis

Lucas OorlynckYera UssembayevJuan FraireCharlotte HinnekensKevin BraeckmansFilip Strubbe

LBL delivery systems for intracellular delivery of therapeutic nucleic acids

Maryam SharifiaghdamJuan FraireKevin Braeckmans

Laser-induced nanobubbles safely ablate vitreous opacities in vivo

Félix SauvageAranit HarizajKaren PeynshaertJuan FraireKatrien RemautKevin BraeckmansStefaan De Smedt

A1 Journal Article in NATURE NANOTECHNOLOGY

Laser-scanning imaging and electrophoresis of single nanoparticles

Filip StrubbeLucas OorlynckYera UssembayevJuan FraireCharlotte HinnekensKevin Braeckmans

Layer-by-Layer self-assembly technique : a tunable tool for delivery of therapeutic nucleic acids

Elnaz Shaabani SichaniJuan FraireKevin Braeckmans

Light triggered nanoscale biolistics for efficient intracellular delivery of functional macromolecules in mammalian cells

Juan FraireElnaz Shaabani SichaniMaryam SharifiaghdamCharlotte HinnekensDawei HuaJana RamonLaurens RaesEduardo Bolea FernandezToon BransFrank VanhaeckePeter BorghgraefFélix SauvageRanhua XiongStefaan De SmedtKevin Braeckmans

A1 Journal Article in NATURE COMMUNICATIONS

Transient nuclear lamin A/C accretion aids in recovery from vapor nanobubble-induced permeabilisation of the plasma membrane

Gaëlle HouthaeveStephan StremerschHerlinde De KeersmaeckerJuan FraireJo VandesompelePieter MestdaghStefaan De SmedtKevin BraeckmansWinnok De Vos

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

2021

Black phosphorus mediated photoporation : a broad absorption nanoplatform for intracellular delivery of macromolecules

Jielin WangAranit HarizajToon BransJuan FraireJulián Mejía MoralesStefaan De SmedtRanhua XiongKevin Braeckmans

A1 Journal Article in NANOSCALE

Carbon quantum dots as a dual platform for the inhibition and light-based destruction of collagen fibers : implications for the treatment of eye floaters

Félix SauvageInès De HoonKevin BraeckmansJuan FraireStefaan De Smedt

A1 Journal Article in NANOSCALE HORIZONS

Cas9 RNP transfection by vapor nanobubble photoporation for ex vivo cell engineering

Melissa PilleAranit HarizajGlenn GoetgelukJelter Van HoeckStephan StremerschJuan FraireToon BransStefaan De SmedtBart VandekerckhoveKoen RaemdonckKevin Braeckmans

A1 Journal Article in MOLECULAR THERAPY-NUCLEIC ACIDS

Cytosolic delivery of gadolinium via photoporation enables improved in vivo magnetic resonance imaging of cancer cells

Aranit HarizajBenedicte DescampsChristophe MangodtStephan StremerschLieve BalcaenToon BransHilde De RoosterNausikaa DevriendtJuan FraireEduardo Bolea FernandezOlivier De WeverWouter WillaertFrank VanhaeckeChristian StevensStefaan De SmedtBart RomanChristian VanhoveIne LentackerKevin Braeckmans

A1 Journal Article in BIOMATERIALS SCIENCE

Enhanced siRNA delivery and selective apoptosis induction in H1299 cancer cells by layer-by-layer-assembled Se nanocomplexes : toward more efficient cancer therapy

Maryam SharifiaghdamElnaz Shaabani SichaniHerlinde De KeersmaeckerRiet De RyckeStefaan De SmedtKevin BraeckmansJuan Fraire

A1 Journal Article in FRONTIERS IN MOLECULAR BIOSCIENCES

Increasing angiogenesis factors in hypoxic diabetic wound conditions by siRNA delivery : additive effect of LbL-gold nanocarriers and desloratadine-induced lysosomal escape

Elnaz Shaabani SichaniMaryam SharifiaghdamJoris LammensHerlinde De KeersmaeckerChris VervaetThomas De BeerStefaan De SmedtKoen RaemdonckKevin BraeckmansJuan Fraire

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Layer by layer assembled chitosan-coated gold nanoparticles for enhanced siRNA delivery and silencing

Elnaz Shaabani SichaniMaryam SharifiaghdamHerlinde De KeersmaeckerRiet De RyckeStefaan De SmedtKevin BraeckmansJuan Fraire

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Macrophage reprogramming into a pro-healing phenotype by siRNA delivered with LBL assembled nanocomplexes for wound healing applications

Maryam SharifiaghdamElnaz Shaabani SichaniHerlinde De KeersmaeckerBart LucasChris VervaetThomas De BeerStefaan De SmedtKevin BraeckmansJuan Fraire

A1 Journal Article in NANOSCALE

Nanoparticle-sensitized photoporation enables inflammasome activation studies in targeted single cells dagger

Aranit HarizajFilip Van HauwermeirenStephan StremerschRiet De RyckeHerlinde De KeersmaeckerToon BransJuan FraireStefaan De SmedtIne LentackerMohamed LamkanfiKevin Braeckmans

A1 Journal Article in NANOSCALE

Photothermal nanofibres enable safe engineering of therapeutic cells

Ranhua XiongDawei HuaJelter Van HoeckDominika BerdeckaLaurens LégerStijn De MunterJuan FraireLaurens RaesAranit HarizajFélix SauvageGlenn GoetgelukMelissa PilleJeffrey AaldersJoke BelzaThibaut Van AckerEduardo Bolea FernandezFrank VanhaeckeBart VandekerckhoveJolanda van HengelKoen RaemdonckStefaan De SmedtKevin Braeckmans

A1 Journal Article in NATURE NANOTECHNOLOGY

2020

Intracellular delivery of mRNA in adherent and suspension cells by vapor nanobubble photoporation

Laurens RaesStephan StremerschJuan FraireToon BransGlenn GoetgelukStijn De MunterLien Van HoeckeRein VerbekeJelter Van HoeckRanhua XiongXavier SaelensBart VandekerckhoveStefaan De SmedtKoen RaemdonckKevin Braeckmans

A1 Journal Article in NANO-MICRO LETTERS

Intracellular labeling with extrinsic probes : delivery strategies and applications

Juan FraireStefaan De SmedtRanhua XiongKevin Braeckmans

A1 Journal Article in SMALL

Vapor nanobubble is the more reliable photothermal mechanism for inducing endosomal escape of siRNA without disturbing cell homeostasis

Juan FraireGaëlle HouthaeveJing LiuLaurens RaesLotte VermeulenStephan StremerschToon BransSarah De KeulenaerFilip Van NieuwerburghRiet De RyckeJo VandesompelePieter MestdaghKoen RaemdonckStefaan De SmedtKevin Braeckmans

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

2019

Delivery of mixed-lineage kinase domain-like protein by vapor nanobubble photoporation induces necroptotic-like cell death in tumor cells

Lien Van HoeckeLaurens RaesStephan StremerschToon BransJuan FraireRia RoelandtWim DeclercqPeter VandenabeeleKoen RaemdonckKevin BraeckmansXavier Saelens

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exploring light-sensitive nanocarriers for simultaneous triggered antibiotic release and disruption of biofilms upon generation of laser-induced vapor nanobubbles

Eline TeirlinckJing LiuJuan FraireRanhua XiongKatrien ForierStefaan De SmedtTom CoenyeKevin Braeckmans

A1 Journal Article in PHARMACEUTICS

Gold nanoparticle-mediated photoporation enables delivery of macromolecules over a wide range of molecular weights in human CD4+ T cells

Laurens RaesClarissa Van HeckeStephan StremerschJuan FraireToon BransRanhua XiongStefaan De SmedtLinos VandekerckhoveKoen RaemdonckKevin Braeckmans

A1 Journal Article in CRYSTALS

Improved label-free identification of individual exosome-like vesicles with Au@Ag nanoparticles as SERS substrate

Juan FraireStephan StremerschTinne MonteyneThomas De BeerPieter WuytensRiet De RyckeAndre SkirtachKoen RaemdonckStefaan De SmedtKevin Braeckmans

A1 Journal Article in ACS APPLIED MATERIALS & INTERFACES

Laser-induced vapor nanobubbles improve diffusion in biofilms of antimicrobial agents for wound care

Eline TeirlinckJuan FraireHeleen Van AckerJasper WilleRosalie SwimbergheToon BransRanhua XiongMaarten MeireRoeland De MoorStefaan De SmedtTom CoenyeKevin Braeckmans

A2 Journal Article in BIOFILM

Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration

Juan FraireKevin Braeckmans

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Photoablation of human vitreous opacities by light-induced vapor nanobubbles

Félix SauvageJuan FraireKatrien RemautKaren PeynshaertRanhua XiongToon BransKevin BraeckmansStefaan De Smedt

A1 Journal Article in ACS NANO

2018

Laser-induced vapour nanobubbles improve drug diffusion and efficiency in bacterial biofilms

Eline TeirlinckRanhua XiongToon BransKatrien ForierJuan FraireHeleen Van AckerNele MatthijsRiet De RyckeStefaan De SmedtTom CoenyeKevin Braeckmans

A1 Journal Article in NATURE COMMUNICATIONS

Photothermally triggered endosomal escape and its influence on transfection efficiency of gold-functionalized JetPEI/pDNA nanoparticles

Lotte VermeulenJuan FraireLaurens RaesEllen De MeesterSarah De KeulenaerFilip Van NieuwerburghStefaan De SmedtKatrien RemautKevin Braeckmans

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Repeated photoporation with graphene quantum dots enables homogeneous labeling of live cells with extrinsic markers for fluorescence microscopy

Jing LiuRanhua XiongToon BransSaskia LippensEef ParthoensJuan FraireEline TeirlinckSangram Keshari SamalRiet De RyckeStefaan De SmedtKevin Braeckmans

A1 Journal Article in LIGHT-SCIENCE & APPLICATIONS