Research Explorer

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Researcher

Juan Fraire

26 Results

2022

Fast laser scanning imaging for single nanoparticle analysis

Lucas OorlynckYera UssembayevJuan FraireCharlotte HinnekensKevin BraeckmansFilip Strubbe

Transient nuclear lamin A/C accretion aids in recovery from vapor nanobubble-induced permeabilisation of the plasma membrane

Gaëlle HouthaeveGerardo García-Díaz BarrigaStephan StremerschHerlinde De KeersmaeckerJuan FraireJo VandesompelePieter MestdaghStefaan De SmedtKevin BraeckmansWinnok De Vos

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

2021

Black phosphorus mediated photoporation : a broad absorption nanoplatform for intracellular delivery of macromolecules

Jielin WangAranit HarizajYongbo WuXiaofang JiangToon BransJuan FraireJulián Mejía MoralesStefaan De SmedtZhilie TangRanhua XiongKevin Braeckmans

A1 Journal Article in NANOSCALE

Carbon quantum dots as a dual platform for the inhibition and light-based destruction of collagen fibers : implications for the treatment of eye floaters

Alexandre BarrasFélix SauvageInès De HoonKevin BraeckmansDawei HuaGaëtan BuvatJuan FraireChristophe LethienJ. SebagMichael HarringtonAmar AbderrahmaniRabah BoukherroubStefaan De SmedtSabine Szunerits

A1 Journal Article in NANOSCALE HORIZONS

Cas9 RNP transfection by vapor nanobubble photoporation for ex vivo cell engineering

Laurens RaesMelissa PilleAranit HarizajGlenn GoetgelukJelter Van HoeckStephan StremerschJuan FraireToon BransOlivier Gerrit de JongRoel Maas-BakkerEnrico MastrobattistaPieter VaderStefaan De SmedtBart VandekerckhoveKoen RaemdonckKevin Braeckmans

A1 Journal Article in MOLECULAR THERAPY-NUCLEIC ACIDS

Cytosolic delivery of gadolinium via photoporation enables improved in vivo magnetic resonance imaging of cancer cells

Aranit HarizajBenedicte DescampsChristophe MangodtStephan StremerschArianna StoppaLieve BalcaenToon BransHilde De RoosterNausikaa DevriendtJuan FraireEduardo Bolea FernandezOlivier De WeverWouter WillaertFrank VanhaeckeChristian StevensStefaan De SmedtBart RomanChristian VanhoveIne LentackerKevin Braeckmans

A1 Journal Article in BIOMATERIALS SCIENCE

Enhanced siRNA delivery and selective apoptosis induction in H1299 cancer cells by layer-by-layer-assembled Se nanocomplexes : toward more efficient cancer therapy

Maryam SharifiaghdamElnaz Shaabani SichaniZeynab SharifiaghdamHerlinde De KeersmaeckerRiet De RyckeStefaan De SmedtReza Faridi-MajidiKevin BraeckmansJuan Fraire

A1 Journal Article in FRONTIERS IN MOLECULAR BIOSCIENCES

Increasing Angiogenesis Factors in Hypoxic Diabetic Wound Conditions by siRNA Delivery: Additive Effect of LbL-Gold Nanocarriers and Desloratadine-Induced Lysosomal Escape

Elnaz ShaabaniMaryam SharifiaghdamJoris LammensHerlinde De KeersmaeckerChris VervaetThomas De BeerElahe MotevaseliMohammad Hossein GhahremaniParvin MansouriStefaan De SmedtKoen RaemdonckReza Faridi-MajidiKevin BraeckmansJuan Fraire

U Journal Article in International Journal of Molecular Sciences

Layer by layer assembled chitosan-coated gold nanoparticles for enhanced siRNA delivery and silencing

Elnaz Shaabani SichaniMaryam SharifiaghdamHerlinde De KeersmaeckerRiet De RyckeStefaan De SmedtReza Faridi-MajidiKevin BraeckmansJuan Fraire

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Macrophage reprogramming into a pro-healing phenotype by siRNA delivered with LBL assembled nanocomplexes for wound healing applications

Maryam SharifiaghdamElnaz Shaabani SichaniZeynab SharifiaghdamHerlinde De KeersmaeckerBart LucasJoris LammensHossein GhanbariLadan Teimoori-ToolabiChris VervaetThomas De BeerReza Faridi-MajidiStefaan De SmedtKevin BraeckmansJuan Fraire

A1 Journal Article in NANOSCALE

Nanoparticle-sensitized photoporation enables inflammasome activation studies in targeted single cells dagger

Aranit HarizajFilip Van HauwermeirenStephan StremerschRiet De RyckeHerlinde De KeersmaeckerToon BransJuan FraireKarolien GrauwenStefaan De SmedtIne LentackerMohamed LamkanfiKevin Braeckmans

A1 Journal Article in NANOSCALE

Photothermal nanofibres enable safe engineering of therapeutic cells

Ranhua XiongDawei HuaJelter Van HoeckDominika BerdeckaLaurens LégerStijn De MunterJuan FraireLaurens RaesAranit HarizajFélix SauvageGlenn GoetgelukMelissa PilleJeffrey AaldersJoke BelzaThibaut Van AckerEduardo Bolea FernandezTing SiFrank VanhaeckeWinnok De VosBart VandekerckhoveJolanda van HengelKoen RaemdonckChaobo HuangStefaan De SmedtKevin Braeckmans

A1 Journal Article in NATURE NANOTECHNOLOGY

2020

Intracellular delivery of mRNA in adherent and suspension cells by vapor nanobubble photoporation

Laurens RaesStephan StremerschJuan FraireToon BransGlenn GoetgelukStijn De MunterLien Van HoeckeRein VerbekeJelter Van HoeckRanhua XiongXavier SaelensBart VandekerckhoveStefaan De SmedtKoen RaemdonckKevin Braeckmans

A1 Journal Article in NANO-MICRO LETTERS

Intracellular delivery of mRNA in adherent and suspension cells by vapor nanobubble photoporation

Laurens RaesStephan StremerschJuan FraireToon BransGlenn GoetgelukStijn De MunterLien Van HoeckeRein VerbekeJelter Van HoeckRanhua XiongXavier SaelensBart VandekerckhoveStefaan De SmedtKoen RaemdonckKevin Braeckmans

A1 Journal Article in NANO-MICRO LETTERS

Intracellular labeling with extrinsic probes : delivery strategies and applications

Jing LiuJuan FraireStefaan De SmedtRanhua XiongKevin Braeckmans

A1 Journal Article in SMALL

Vapor nanobubble is the more reliable photothermal mechanism for inducing endosomal escape of siRNA without disturbing cell homeostasis

Juan FraireGaëlle HouthaeveJing LiuLaurens RaesLotte VermeulenStephan StremerschToon BransGerardo Garcia-Diaz BarrigaSarah De KeulenaerFilip Van NieuwerburghRiet De RyckeJo VandesompelePieter MestdaghKoen RaemdonckWinnok H. De VosStefaan De SmedtKevin Braeckmans

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

2019

Delivery of mixed-lineage kinase domain-like protein by vapor nanobubble photoporation induces necroptotic-like cell death in tumor cells

Lien Van HoeckeLaurens RaesStephan StremerschToon BransJuan FraireRia RoelandtWim DeclercqPeter VandenabeeleKoen RaemdonckKevin BraeckmansXavier Saelens

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exploring light-sensitive nanocarriers for simultaneous triggered antibiotic release and disruption of biofilms upon generation of laser-induced vapor nanobubbles

Eline TeirlinckAlexandre BarrasJing LiuJuan FraireTatu LajunenRanhua XiongKatrien ForierChengnan LiArto UrttiRabah BoukherroubSabine SzuneritsStefaan De SmedtTom CoenyeKevin Braeckmans

A1 Journal Article in PHARMACEUTICS

Gold nanoparticle-mediated photoporation enables delivery of macromolecules over a wide range of molecular weights in human CD4+ T cells

Laurens RaesClarissa Van HeckeJulie MichielsStephan StremerschJuan FraireToon BransRanhua XiongStefaan De SmedtLinos VandekerckhoveKoen RaemdonckKevin Braeckmans

A1 Journal Article in CRYSTALS

Improved label-free identification of individual exosome-like vesicles with Au@Ag nanoparticles as SERS substrate

Juan FraireStephan StremerschDavinia BouckaertTinne MonteyneThomas De BeerPieter WuytensRiet De RyckeAndre SkirtachKoen RaemdonckStefaan De SmedtKevin Braeckmans

A1 Journal Article in ACS APPLIED MATERIALS & INTERFACES

Laser-induced vapor nanobubbles improve diffusion in biofilms of antimicrobial agents for wound care

Eline TeirlinckJuan FraireHeleen Van AckerJasper WilleRosalie SwimbergheToon BransRanhua XiongMaarten MeireRoeland De MoorStefaan De SmedtTom CoenyeKevin Braeckmans

A2 Journal Article in BIOFILM

Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration

Kaushik ThankiDelphine van EetveldeAntonia GeyerJuan FraireRemi HendrixHannelore Van EygenEmma PuttemanHaider SamiCristiane de Souza Carvalho-WodarzHenrik FranzykHanne Mørck NielsenKevin BraeckmansClaus-Michael LehrManfred OgrisCamilla Foged

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Photoablation of human vitreous opacities by light-induced vapor nanobubbles

Félix SauvageJuan FraireKatrien RemautJ SebagKaren PeynshaertMichael HarringtonFrans J Van de VeldeRanhua XiongMarie-Jose TassignonToon BransKevin BraeckmansStefaan De Smedt

A1 Journal Article in ACS NANO

2018

Laser-induced vapour nanobubbles improve drug diffusion and efficiency in bacterial biofilms

Eline TeirlinckRanhua XiongToon BransKatrien ForierJuan FraireHeleen Van AckerNele MatthijsRiet De RyckeStefaan De SmedtTom CoenyeKevin Braeckmans

A1 Journal Article in NATURE COMMUNICATIONS

Photothermally triggered endosomal escape and its influence on transfection efficiency of gold-functionalized JetPEI/pDNA nanoparticles

Lotte VermeulenJuan FraireLaurens RaesEllen De MeesterSarah De KeulenaerFilip Van NieuwerburghStefaan De SmedtKatrien RemautKevin Braeckmans

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Repeated photoporation with graphene quantum dots enables homogeneous labeling of live cells with extrinsic markers for fluorescence microscopy

Jing LiuRanhua XiongToon BransSaskia LippensEef ParthoensFrancesca Cella ZanacchiRaffaella MagrassiSantosh K SinghSreekumar KurungotSabine SzuneritsHannelore BovéMarcel AmelootJuan FraireEline TeirlinckSangram Keshari SamalRiet De RyckeGaëlle HouthaeveStefaan De SmedtRabah BoukherroubKevin Braeckmans

A1 Journal Article in LIGHT-SCIENCE & APPLICATIONS