Research Explorer

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Researcher

Joske Millecam

Awards & Distinctions

25 Results

2020

Enantiomer specific pharmacokinetics of ibuprofen in preterm neonates with patent ductus arteriosus

Aline G.J. EngbersRobert B. FlintSwantje VöllerJohan C.A. de KlerkIrwin K.M. ReissPeter AndriessenKian D. LiemPieter L.J. DegraeuweSiska CroubelsJoske Millecam et al.

A1 Journal Article in BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Gastrostomy tube placement via a laparotomic procedure in growing conventional piglets to perform multi-dose preclinical paediatric drug studies

Joske MillecamThomas van BergenMathias DevreeseStijn SchauvliegeAnn MartensKoen ChiersSiska CroubelsGunther Antonissen

A1 Journal Article in LABORATORY ANIMALS

Simultaneous measurement of glomerular filtration rate, effective renal plasma flow and tubular secretion in different poultry species by single intravenous bolus of iohexol and para-aminohippuric acid

Lenka StroobantSiska CroubelsLaura DhondtJoske MillecamSiegrid De BaereElke GasthuysJ MorrensGunther Antonissen

A1 Journal Article in ANIMALS

2019

Characterization of porcine hepatic and intestinal drug metabolizing CYP450 : comparison with human orthologues from a quantitative, activity and selectivity perspective

Wim SchelstraeteLaura De ClerckElisabeth GovaertJoske MillecamMathias DevreeseDieter DeforceJan Van BocxlaerSiska Croubels

A1 Journal Article in SCIENTIFIC REPORTS

Developmental pharmacokinetics and safety of ibuprofen and its enantiomers in the conventional pig as potential pediatric animal model

Joske MillecamThomas van BergenStijn SchauvliegeGunther AntonissenAnn MartensKoen ChiersRonette GehringElke GasthuysJohan Vande WalleSiska Croubels et al.

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

In vivo metabolism of ibuprofen in growing conventional pigs : a pharmacokinetic approach

Joske MillecamSiegrid De BaereSiska CroubelsMathias Devreese

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

The conventional pig as juvenile animal model for preclinical paediatric pharmacokinetic studies : focus on hepatic metabolism using ibuprofen as model compound

Joske MillecamSiska CroubelsMathias Devreese

2018

A novel approach in paediatric drug research : the development of a juvenile pig model for pharmacokinetic/pharmacodynamic studies, using desmopressin as case 1

Elke GasthuysJoske MillecamMathias DevreeseAn VermeulenPauline De BruyneJohan Vande WalleJoris DelangheSiska Croubels

Conventional growing piglets as potential juvenile animal model for preclinical pharmaceutical research : postnatal maturation of the glomerular filtration rate

Elke GasthuysJoske MillecamMathias DevreeseJoris DelangheJohan Vande WalleMarjolein HeyndrickxSiska Croubels

Maturation of hepatic cytochrome P450 enzymes in conventional pigs : fact or fiction?

Joske MillecamLaura De ClerckElisabeth GovaertMathias DevreeseElke GasthuysWim SchelstraeteDieter DeforceLies De BockJan Van BocxlaerStanislas Sys et al.

Maturation of hepatic cytochrome P450 enzymes in conventional pigs : the added value of proteomics

Joske MillecamLaura De ClerckElisabeth GovaertMathias DevreeseElke GasthuysWim SchelstraeteDieter DeforceLies De BockJan Van BocxlaerStanislas Sys et al.

Maturation of hepatic cytochrome P450 enzymes in conventional pigs as model for preclinical paediatric drug research

Joske MillecamLaura De ClerckElisabeth GovaertMathias DevreeseElke GasthuysWim SchelstraeteDieter DeforceLies De BockJan Van BocxlaerStanislas Sys et al.

Pharmacokinetics of ibuprofen in very preterm infants with patent ductus arteriosus

Aline EngbersRobert FlintSwantje VöllerJohan de KlerkIrwin ReissPeter AndriessenDjien LiemPieter DegraeuweSiska CroubelsJoske Millecam et al.

Population pharmacokinetic modeling of a desmopressin oral lyophilisate in growing piglets as a model for the pediatric population

Elke GasthuysAn VermeulenSiska CroubelsJoske MillecamStijn SchauvliegeThomas van BergenPauline De BruyneJohan Vande WalleMathias Devreese

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

Population pharmacokinetic modeling of a desmopressin oral lyophilisate in growing piglets as a model for the pediatric population

Elke GasthuysAn VermeulenSiska CroubelsPauline De BruyneJoske MillecamJohan Vande WalleMathias Devreese

The ontogeny of cytochrome P450 enzyme activity and protein abundance in conventional pigs in support of preclinical pediatric drug research

Joske MillecamLaura De ClerckElisabeth GovaertMathias DevreeseElke GasthuysWim SchelstraeteDieter DeforceLies De BockJan Van BocxlaerStanislas Sys et al.

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

2017

A new approach in pediatric drug design : the development of a pediatric pig model, part II : the maturation of hepatic cytochrome P450 enzymes using enzyme activity and proteomics

Joske MillecamElke GasthuysMathias DevreeseDieter DeforceLies De BockJan Van BocxlaerSiska Croubels

A novel approach in paediatric drug design : the conventional pig as juvenile animal model

Joske MillecamElke GasthuysMathias DevreeseSiska Croubels

Population pharmacokinetic modeling of the glomerular filtration rate in growing piglets using iohexol

Elke GasthuysJoske MillecamSiska CroubelsRonette GehringMathias Devreese

Postnatal maturation of the glomerular filtration rate in conventional growing piglets as potential juvenile animal model for preclinical pharmaceutical research

Elke GasthuysMathias DevreeseJoske MillecamStanislas SysKatrien VanderperrenJoris DelangheJohan Vande WalleMarjolein HeyndrickxSiska Croubels

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

Repetitive urine and blood sampling in neonatal and weaned piglets for pharmacokinetic and pharmacodynamic modelling in drug discovery : a pilot study

Elke GasthuysStijn SchauvliegeThomas van BergenJoske MillecamIlaria CerasoliAnn MartensFrank GasthuysTim VandecasteelePieter CornillieWim Van Den Broeck et al.

A1 Journal Article in LABORATORY ANIMALS

The conventional pig as PK/PD/toxicity model for the pediatric subpopulation : development of urine and blood sampling strategies in growing piglets

Elke GasthuysThomas van BergenStijn SchauvliegeJoske MillecamSiska CroubelsMathias Devreese

The ontogeny of hepatic cytochrome P450 enzymes in conventional pigs using enzyme activity and proteomics

Joske MillecamElke GasthuysMathias DevreeseDieter DeforceJan Van BocxlaerSiska Croubels

2015

Comparison of iohexol and endogenous creatinine clearance as estimators of glomerular filtration rate in piglets at different age categories

Elke GasthuysMathias DevreeseJoske MillecamPatrick De BackerSiska Croubels

The ontogeny of hepatic CYP3A, CYP2C and CYP2E enzyme activity in conventional pigs

Joske MillecamMathias DevreeseLies De BockJan Van BocxlaerElke GasthuysPatrick De BackerSiska Croubels