Research Explorer

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Researcher

Jorick Franceus

Awards & Distinctions

31 Results

2025

Synthesis and functional screening of novel inhibitors targeting the HDAC6 zinc finger ubiquitin-binding domain

Silke GeursEleni StaessensKato BredaelStefaan BorghgraefJordy De RidderLeentje PersoonsSteven De JongheDominique ScholsMandeep K. MannRachel J. Harding et al.

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

2024

CANDy : automated analysis of domain architectures in carbohydrate-active enzymes

Alex WindelsJorick FranceusJuergen PleissTom Desmet

A1 Journal Article in PLOS ONE

Converting bulk sugars into functional fibers : discovery and application of a thermostable β-1,3-oligoglucan phosphorylase

Marc De DonckerSofie VleminckxJorick FranceusRonny VercauterenTom Desmet

A1 Journal Article in JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Evolution of phosphorylase activity in an ancestral glycosyltransferase

Jorick FranceusJose Pablo Rivas-FernandezJolien LormansCarme RoviraTom Desmet

A1 Journal Article in ACS CATALYSIS

High-yield synthesis of 2-O-α-d-glucosyl-d-glycerate by a bifunctional glycoside phosphorylase

Jorick FranceusManon SteynenYentl AllaertKato BredaelMatthias D'hoogheTom Desmet

A1 Journal Article in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Strategies for the synthesis of the osmolyte glucosylglycerate and its precursor glycerate

Yentl AllaertArthur LeyderJorick FranceusTom Desmet

A1 Journal Article in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Synthesis of pyrrolidine-fused β-lactams as potential β-lactamase inhibitors

Sari DeketelaereCarlos Diez-PozaMargot AelbrechtJonas MortierBram Van Den BosscheJorick FranceusTom DesmetKristof Van HeckeChristian StevensMatthias D'hooghe

A1 Journal Article in ASIAN JOURNAL OF ORGANIC CHEMISTRY

The many functions of carbohydrate-active enzymes in family GH65 : diversity and application

Emma De BeulJorick FranceusTom Desmet

A1 Journal Article in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

2022

Building mutational bridges between carbohydrate-active enzymes

Jorick FranceusJolien LormansTom Desmet

A1 Journal Article in CURRENT OPINION IN BIOTECHNOLOGY

Identification of mercaptoacetamide-based HDAC6 inhibitors via a lean inhibitor strategy : screening, synthesis, and biological evaluation

Silke GeursDorien ClarisseFreya BaeleJorick FranceusTom DesmetKarolien De BosscherMatthias D'hooghe

A1 Journal Article in CHEMICAL COMMUNICATIONS

Insertions and deletions in protein evolution and engineering

Simone SavinoTom DesmetJorick Franceus

A1 Journal Article in BIOTECHNOLOGY ADVANCES

2021

Discovery of a kojibiose hydrolase by analysis of specificity-determining correlated positions in Glycoside Hydrolase Family 65

Emma De BeulAlana JongbloetJorick FranceusTom Desmet

A1 Journal Article in MOLECULES

Engineering of a thermostable biocatalyst for the synthesis of 2-O-glucosylglycerol

Jorick FranceusZorica UbiparipKoen BeerensTom Desmet

A1 Journal Article in CHEMBIOCHEM

Evolution of phosphorylases from N-acetylglucosaminide hydrolases in family GH3

Jorick FranceusJolien LormansLore CoolsMatthias D'hoogheTom Desmet

A1 Journal Article in ACS CATALYSIS

Exploration of GH94 sequence space for enzyme discovery reveals a novel glucosylgalactose phosphorylase specificity

Marc De DonckerChloé De GraeveJorick FranceusKoen BeerensVladimír KřenHelena PelantováRonny VercauterenTom Desmet

A1 Journal Article in CHEMBIOCHEM

β-Glucan phosphorylases in carbohydrate synthesis

Zorica UbiparipMarc De DonckerKoen BeerensJorick FranceusTom Desmet

A1 Journal Article in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

2020

Sucrose phosphorylase and related enzymes in glycoside hydrolase family 13 : discovery, application and engineering

Jorick FranceusTom Desmet

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Synthesis, trehalase hydrolytic resistance and inhibition properties of 4-and 6-substituted trehalose derivatives

Shari DhaeneJohan Van der EyckenKoen BeerensJorick FranceusTom DesmetJurgen Caroen

A1 Journal Article in JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

2019

Discovery of novel cellodextrin phosphorylases : where bioinformatics meets biochemistry

Zorica UbiparipJorick FranceusNídia MartinsKoen BeerensTom Desmet

Exploring and engineering the functional diversity of glycoside phosphorylases

Jorick FranceusTom Desmet

Rational design of an improved transglucosylase for production of the rare sugar nigerose

Jorick FranceusShari DhaeneHannes DecadtJudith VandepitteJurgen CaroenJohan Van der EyckenKoen BeerensTom Desmet

A1 Journal Article in CHEMICAL COMMUNICATIONS

Structural comparison of a promiscuous and a highly specific sucrose 6F-phosphate phosphorylase

Jorick FranceusNikolas CapraTom DesmetAndy-Mark W.H. Thunnissen

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Synthesis of indoline‐based benzhydroxamic acids as potential HDAC6 inhibitors

Yves DepetterSilke GeursJorick FranceusDamijan KnezTom DesmetKarolien De BosscherOlivier De WeverStanislav GobecMatthias D'hooghe

A1 Journal Article in CHEMISTRYSELECT

2018

Assessment of the trifluoromethyl ketone functionality as an alternative zinc-binding group for selective HDAC6 inhibition

Yves DepetterSilke GeursFlore Vanden BusscheRob De VreeseJorick FranceusTom DesmetOlivier De WeverMatthias D'hooghe

A1 Journal Article in MEDCHEMCOMM

Chemoenzymatic approach toward the synthesis of 3-O-(α/β)-glucosylated 3-hydroxy-β-lactams

Lena DecuyperJorick FranceusShari DhaeneMaarten DebruyneKevin VandoorneNicola PiensGriet DewitteTom DesmetMatthias D'hooghe

A1 Journal Article in ACS OMEGA

Exploring the sequence diversity in glycoside hydrolase family 13_18 reveals a novel glucosylglycerol phosphorylase

Jorick FranceusLena DecuyperMatthias D'hoogheTom Desmet

A1 Journal Article in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Thermostable alpha-glucan phosphorylases : characteristics and industrial applications

Zorica UbiparipKoen BeerensJorick FranceusRonny VercauterenTom Desmet

A1 Journal Article in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

2017

Correlated positions in protein evolution and engineering

Jorick FranceusTom VerhaegheTom Desmet

A1 Journal Article in JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Glucosylglycerate phosphorylase, an enzyme with novel specificity involved in compatible solute metabolism

Jorick FranceusDenise PinelTom Desmet

A1 Journal Article in APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Synthesis of potent and selective HDAC6 inhibitors bearing a cyclohexane- or cycloheptane-annulated 1,5-benzothiazepine scaffold

Rob De VreeseLisa GalleYves DepetterJorick FranceusTom DesmetKristof Van HeckeVeronick BenoyLudo Van Den BoschMatthias D'hooghe

A1 Journal Article in CHEMISTRY-A EUROPEAN JOURNAL

2016

Diastereoselective synthesis of 3-acetoxy-4-(3-aryloxiran-2-yl)azetidin-2-ones and their transformation into 3,4-oxolane-fused bicyclic β-lactams

Nicola PiensSven De CraeneJorick FranceusKaren MolletKristof Van HeckeTom DesmetMatthias D'hooghe

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY