Research Explorer

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Researcher

Joni Van der Meulen

Awards & Distinctions

72 Results

2025

A nationwide comprehensive genomic profiling and molecular tumor board platform for patients with advanced cancer

Pieter-Jan VoldersPhilippe AftimosFranceska DedeurwaerdereGeert MartensJean-Luc CanonGabriela BeniugaGuy FroyenJacques Van HuysseRebecca De PauwHans Prenen et al.

A1 Journal Article in NPJ PRECISION ONCOLOGY

Atypical spindle cell/pleomorphic lipomatous tumour : a clinicopathologic, immunohistochemical and molecular study of 55 cases, highlighting TP53 gene alterations as a genetic hallmark of atypical pleomorphic lipomatous tumour

Fleur CordierTony G KleijnThomas MentzelUta FluckeJoost van GorpLiesbeth FerdinandeSarah Van BelleSiebe LoontiensJoni Van der MeulenJo Van Dorpe et al.

A1 Journal Article in HISTOPATHOLOGY

Prospective, multicenter validation of a platform for rapid molecular profiling of central nervous system tumors

Areeba PatelKirsten GöbelSebastian IlleFelix HinzNatalie SchoebeHenri BogumilJochen MeyerMichelle BrehmHelin KardoDaniel Schrimpf et al.

A1 Journal Article in NATURE MEDICINE

Revealing RB1 loss in an emerging entity : report of two cases of PRRX1-rearranged mesenchymal tumours

Fleur CordierSharareh FadaeiLiesbeth FerdinandeFrederick DochyLieve VanwalleghemKarolien Van Den BosscheSiebe LoontiensJoni Van der MeulenNadine Van RoyJo Van Dorpe et al.

A1 Journal Article in JOURNAL OF CLINICAL PATHOLOGY

2024

A case of a lipoblastoma with EEF1A1::PLAG1 fusion and metaplastic ossification

Ellen DeoletFleur CordierLiesbeth FerdinandeSiebe LoontiensJoni Van der MeulenJo Van DorpeDavid Creytens

A1 Journal Article in GENES CHROMOSOMES & CANCER

A challenging case of an intraosseous composite hemangioendothelioma of the occipital bone with YAP1::FOXR1 fusion

Fleur CordierLiesbeth FerdinandeSiebe LoontiensJoni Van der MeulenJo Van DorpeDavid Creytens

A1 Journal Article in GENES CHROMOSOMES & CANCER

Identification of potentially actionable genetic variants in epithelial ovarian cancer : a retrospective cohort study

Charlotte FieuwsJoni Van der MeulenKristiaan ProesmansEmiel De JaeghereSiebe LoontiensJo Van DorpePhilippe TummersHannelore DenysKoen Van de VijverKathleen Claes

A1 Journal Article in NPJ PRECISION ONCOLOGY

RAF1-rearranged spindle cell mesenchymal tumor with calcification and heterotopic ossification : a case report and review of literature

Fleur CordierSiebe LoontiensJoni Van der MeulenLore LapeireGabriëlle van RamshorstGwen SysJo Van DorpeDavid Creytens

A1 Journal Article in INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY

2023

Formalin-fixed, paraffin-embedded–targeted locus capture : a next-generation sequencing technology for accurate DNA-based gene fusion detection in bone and soft tissue tumors

Ellen StellooRuud W.J. MeijersJoost F. SwennenhuisAmin AllahyarKarima HajoMario CangianoWendy W.J. de LengSjoerd van HelvertJoni Van der MeulenDavid Creytens et al.

A1 Journal Article in JOURNAL OF MOLECULAR DIAGNOSTICS

HRAS-related epidermal nevus syndromes : expansion of the spectrum with first branchial arch defects

Aude BeyensCharlotte LietaerKathleen ClaesElfride De BaereMarleen GoeteynBob LerutHannes SyrynOlivier VanakkerJoni Van der MeulenLieve Vanwalleghem et al.

A1 Journal Article in CLINICAL GENETICS

High-grade endometrial stromal sarcoma-like sarcoma in male : does it exist? A case report and review of the literature

Fleur CordierJoni Van der MeulenSiebe LoontiensNadine Van RoyLore LapeireWouter WillaertLiesbeth FerdinandeKoen Van de VijverJo Van DorpeDavid Creytens

A1 Journal Article in PATHOLOGY RESEARCH AND PRACTICE

2022

Application of an ultrasensitive NGS-based blood test for the diagnosis of early-stage lung cancer : sensitivity, a hurdle still difficult to overcome

Malaïka Van der LindenBram Van GaeverLennart RamanKarim VermaelenIngel DemedtsVeerle SurmontUlrike HimpeYolande LievensLiesbeth FerdinandeFranceska Dedeurwaerdere et al.

A1 Journal Article in CANCERS

Extrauterine mesonephric-like neoplasms : expanding the morphologic spectrum

Ellen DeoletIteeka AroraJo Van DorpeJoni Van der MeulenSudha DesaiNadine Van RoyBaljeet KaurKoen Van de VijverW Glenn McCluggage

A1 Journal Article in AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Malignant pleural mesothelioma with an EML4-ALK fusion : expect the unexpected!

Fleur CordierJoni Van der MeulenNadine Van RoyJilke De WildeHerwig van DijckFilip VanhoenackerMarc LambrechtsValentin NoyezKoen Van de VijverLiesbeth Ferdinande et al.

A1 Journal Article in PATHOLOGY RESEARCH AND PRACTICE

PRECISION : the Belgian molecular profiling program of metastatic cancer for clinical decision and treatment assignment

J. ThouveninC. Van MarckeL. DecosterG. RaicevicK. PunieM. VandenbulckeR. SalgadoE. Van ValckenborghB. MaesS. Joris et al.

A1 Journal Article in ESMO OPEN

Primary cutaneous epithelioid inflammatory myofibroblastic sarcoma harboring RANBP2-ALK fusion : report of an exceptional case

Laura GadeyneDavid CreytensSam DekeyserJoni Van der MeulenMarc Haspeslagh

A1 Journal Article in AMERICAN JOURNAL OF DERMATOPATHOLOGY

Undifferentiated sarcoma of bone with a round to epithelioid cell phenotype harboring a novel EWSR1-SSX2 fusion identified by RNA-based next-generation sequencing

Fleur CordierJoni Van der MeulenBram Van GaeverLore LapeireGwen SysJo Van DorpeDavid Creytens

A1 Journal Article in GENES CHROMOSOMES & CANCER

mRNA capture sequencing and RT-qPCR for the detection of pathognomonic, novel, and secondary fusion transcripts in FFPE tissue : a sarcoma showcase

Anneleen DecockDavid CreytensSteve LefeverJoni Van der MeulenJasper AnckaertAriane De GanckJill DeleuBram De WildeCarolina FierroScott Kuersten et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2021

An undifferentiated sarcoma of bone with a round to epithelioid cell phenotype harboring a novel EWSR1-SSX2 fusion identified by RNA-based next-generation sequencing

Fleur CordierJoni Van der MeulenBram Van GaeverLore LapeireGwen SysJo Van DorpeDavid Creytens

Comparison of microsatellite instability detection by immunohistochemistry and molecular techniques in colorectal and endometrial cancer

Franceska DedeurwaerdereKathleen ClaesJo Van DorpeIsabelle RottiersJoni Van der MeulenJoke BreyneKoen SwaertsGeert Martens

A1 Journal Article in SCIENTIFIC REPORTS

MYCN-induced nucleolar stress drives an early senescence-like transcriptional program in hTERT-immortalized RPE cells

Sofia ZanottiSuzanne VanhauwaertChristophe Van NesteVolodimir OlexioukJolien Van LaereMarlies VerschuurenJoni Van der MeulenLiselot MusKaat DurinckLaurentijn Tilleman et al.

A1 Journal Article in SCIENTIFIC REPORTS

Malignant pleural mesothelioma with an EML4-ALK fusion : expect the unexpected!

Fleur CordierJoni Van der MeulenNadine Van RoyHerwig Van DijckFilip VanhoenackerMarc LambrechtsValentin NoyezLiesbeth FerdinandeAmélie DendoovenJo Van Dorpe et al.

Myxoid hepatocellular adenoma, a rare variant of hepatocellular adenoma with distinct imaging features : a case report with immunohistochemical and molecular analysis and literature review

Nicolas De VosJoni Van der MeulenMalaïka Van der LindenKathleen ClaesAnn-Sophie CandaeleAude VanlanderRoberto TroisiHans Van VlierberghePeter SmeetsJo Van Dorpe et al.

A1 Journal Article in CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY

2020

Distinct Notch1 and BCL11B requirements mediate human γδ/αβ T cell development

Anne-Catherine DolensKaat DurinckMarieke LavaertJoni Van der MeulenImke VelgheJelle De MedtsKarin WeeningJuliette RoelsKatrien De MulderPieter-Jan Volders et al.

A1 Journal Article in EMBO REPORTS

Establishment and characterization of a cell line and patient-derived xenograft (PDX) from peritoneal metastasis of low-grade serous ovarian carcinoma

Elien De ThayeKoen Van de VijverJoni Van der MeulenJoachim TaminauGlenn WagemansHannelore DenysJo Van DorpeGeert BerxWim CeelenJan Van Bocxlaer et al.

A1 Journal Article in SCIENTIFIC REPORTS

Intracranial myxoid mesenchymal tumor with EWSR1-CREB1 fusion

Sasha LibbrechtJoni Van der MeulenVeerle MondelaersEdward BaertCAROLINE VANDE WALLEJo Van DorpeDavid Creytens

A1 Journal Article in PATHOLOGY RESEARCH AND PRACTICE

Weak MGMT gene promoter methylation confers a clinically significant survival benefit in patients with newly diagnosed glioblastoma : a retrospective cohort study

Harry PinsonGiorgio HallaertJoni Van der MeulenF DedeurwaerdereD VanhauwaertCaroline Van den BroeckeJo Van DorpeDirk Van RoostJean-Pierre Kalala OkitoTom Boterberg

A1 Journal Article in JOURNAL OF NEURO-ONCOLOGY

2019

A case report of acute panmyelosis with myelofibRosis (APMF) with a distinct molecular pattern

Emilie De MaertelaereKarl VandepoeleJoni Van der MeulenIne MoorsWillem DaneelsAnke DelieJan PhilippéCarolien BonroyKatrien DevreeseNadine Van Roy et al.

A fast, affordable and minimally-invasive diagnostic test for Cancer of Unknown Primary (CUP) using DNA methylation profiling

Jilke De WildeRuben Van PaemelCharlotte VandeputteAndries De KokerJoni Van der MeulenMalaïka Van der LindenNico CallewaertJo Van DorpeDavid CreytensBram De Wilde et al.

Algorithms for molecular testing in solid tumours

A. HébrantM. LammensC. Van den BroeckeN. D’HaeneJ. Van den OordA. VandersticheleA. DendoovenP. NevenK. PunieG. Floris et al.

A2 Journal Article in BELGIAN JOURNAL OF MEDICAL ONCOLOGY

Cost-effective and robust genotyping using double-mismatch allele-specific quantitative PCR

Steve LefeverAli RihaniJoni Van der MeulenFilip PattynTom Van MaerkenJo Van DorpeJan HellemansJo Vandesompele

A1 Journal Article in SCIENTIFIC REPORTS

Faster, cheaper and more accurate diagnosis of cancer of unknown primary (CUP) by using methylation profiling.

Jilke De WildeRuben Van PaemelCharlotte VandeputteAndries De KokerJoni Van der MeulenMalaïka Van der LindenNico CallewaertJo Van DorpeDavid CreytensBram De Wilde et al.

Long term response on Regorafenib in non-V600E BRAF mutated colon cancer: a case report

Eduard CalleboutSuzane Moura RibeiroStéphanie LaurentMarc De ManLiesbeth FerdinandeKathleen ClaesJoni Van der MeulenKaren Geboes

A1 Journal Article in BMC CANCER

Standardization of somatic variant classifications in solid and haematological tumours by a two-Level approach of biological and clinical classes : an Initiative of the Belgian ComPerMed Expert Panel

Guy FroyenMarie Le MercierEls LiermanKarl VandepoeleFriedel NolletElke BooneJoni Van der MeulenKoen JacobsSuzan LambinSara Vander Borght et al.

A1 Journal Article in CANCERS

Variant calling and fusion gene detection in formalin-fixed paraffin-embedded tumor tissue using RNA capture sequencing

Anneleen DecockDavid CreytensJoni Van der MeulenSandra SteyaertCarolina FierroManuel LuypaertSteve LefeverEveline Vanden EyndeKatrien VanderheydenKimberly Verniers et al.

2018

A case of chronic eosinophilic leukemia with secondary transformation to acute myeloid leukemia

Mattias HofmansAnke DelieKarl VandepoeleNadine Van RoyJoni Van der MeulenJan PhilippéIne Moors

A2 Journal Article in LEUKEMIA RESEARCH REPORTS

Fusion gene detection and variant calling in formalin-fixed paraffin-embedded tumor tissue using mRNA capture sequencing

Anneleen DecockDavid CreytensJoni Van der MeulenSandra SteyaertKimberly VerniersKatrien VanderheydenManuel LuypaertThibaut D’huyvetterIsabelle RottiersJo Van Dorpe et al.

The NF1 hotspot in acute myeloid leukemia : what’s in a name?

Karl VandepoeleJoni Van der MeulenBarbara Denys

A1 Journal Article in LEUKEMIA

Two cases of seborrheic keratosis of the external ear canal : involvement of PIK3CA and FGFR3 genes

MARIE DE LOOFJo Van DorpeJoni Van der MeulenSteve LefeverIngeborg Dhooge

A1 Journal Article in INTERNATIONAL JOURNAL OF DERMATOLOGY

2017

In-house developed 15-gene sequencing panel for acute myeloid leukemia and myelodysplasia allows robust detection of genetic defects including FLT3-ITD and CEBPA mutations

Joni Van der MeulenBarbara DenysElien De LatterSteve LefeverToon RosseelWouter SteyaertGRETA VAN DER CRUYSSENIsabelle RottiersDavid CreytensJo Van Dorpe et al.

In-house developed 15-gene sequencing panel for acute myeloid leukemia and myelodysplasia allows robust detection of genetic defects including FLT3-ITD and CEBPA mutations

Joni Van der MeulenBarbara DenysElien De LatterSteve LefeverToon RosseelWouter SteyaertGRETA VAN DER CRUYSSENIsabelle RottiersDavid CreytensJo Van Dorpe et al.

2016

Expanding the TLX1 regulome in T-cell acute lymphoblastic leukemia towards long noncoding RNAs

Kaat DurinckWouter Van LoockeInge Van de WalleJoni Van der MeulenPieter-Jan VoldersNadine Van RoyYves BenoitBruce PoppePieter MestdaghJo Vandesompele et al.

2015

Characterization of the genome-wide TLX1 binding profile in T-cell acute lymphoblastic leukemia

Kaat DurinckWouter Van LoockeJoni Van der MeulenInge Van de WalleMaté OngenaertPieter RondouAnnelynn WallaertCE de BockNadine Van RoyBruce Poppe et al.

A1 Journal Article in LEUKEMIA

Epigenetics in T-cell acute lymphoblastic leukemia

Sofie PeirsJoni Van der MeulenInge Van de WalleTom TaghonFranki SpelemanBruce PoppePieter Van Vlierberghe

A1 Journal Article in IMMUNOLOGICAL REVIEWS

MicroRNA-193b-3p acts as a tumor suppressor by targeting the MYB oncogene in T-cell acute lymphoblastic leukemia

Evelien MetsJoni Van der MeulenGert Van PeerMichael BoicePieter MestdaghInge Van de WalleTim LammensSteven GoossensBarbara De MoerlooseYves Benoit et al.

A1 Journal Article in LEUKEMIA

The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia

Joni Van der MeulenViraj SanghviKonstantinos MavrakisKaat DurinckFang FangFilip MatthijssensPieter RondouMonica RosenTim PietersPeter Vandenberghe et al.

A1 Journal Article in BLOOD

Transcriptional antagonism between the cooperative oncogenes TLX1 and NOTCH1 in T-cell acute lymphoblastic leukemia.

Kaat DurinckWouter Van LoockeJoni Van der MeulenInge Van de WallePieter RondouCharles E De BockBruce PoppeJan CoolsJean SoulierTom Taghon et al.

ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling

Steven GoossensEnrico RadaelliOdile BlanchetKaat DurinckJoni Van der MeulenSofie PeirsTom TaghonCedric S TremblayMagdaline CostaMorvarid Farhang Ghahremani et al.

A1 Journal Article in NATURE COMMUNICATIONS

2014

Characterization of a set of tumor suppressor microRNAs in T cell acute lymphoblastic leukemia

Viraj R SanghviKonstantinos J MavrakisJoni Van der MeulenMichael BoiceAndrew L WolfeMark CartyPrathibha MohanPieter RondouNicholas D SocciYves Benoit et al.

A1 Journal Article in SCIENCE SIGNALING

Lost in transcription : emergence of epigenetic drivers and microRNAs in T-cell acute lymphoblastic leukemia

Joni Van der MeulenFranki SpelemanYves Benoit

MicroRNA-128-3p is a novel oncomiR targeting PHF6 in T-cell acute lymphoblastic leukemia

Evelien MetsGert Van PeerJoni Van der MeulenMichael BoiceTom TaghonSteven GoossensPieter MestdaghYves BenoitBarbara De MoerlooseNadine Van Roy et al.

A1 Journal Article in HAEMATOLOGICA

RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer

Andrew L WolfeKamini SinghYi ZhongPhilipp DreweVinagolu K RajasekharViraj R SanghviKonstantinos J MavrakisMan JiangJustine E RoderickJoni Van der Meulen et al.

A1 Journal Article in NATURE

The H3K27me3 demethylase UTX in normal development and disease

Joni Van der MeulenFranki SpelemanPieter Van Vlierberghe

A1 Journal Article in EPIGENETICS

The epigenetic landscape of T-cell acute lymphoblastic leukemia

Joni Van der MeulenNadine Van RoyPieter Van VlierbergheFranki Speleman

A1 Journal Article in INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

2013

Effective Alu repeat based RT-qPCR normalization in cancer cell perturbation experiments

Ali RihaniTom Van MaerkenFilip PattynGert Van PeerAnneleen BeckersSara De BrouwerCandy KumpsEvelien MetsJoni Van der MeulenPieter Rondou et al.

A1 Journal Article in PLOS ONE

Expanding the TLX1 regulate in T-cell acute lymphoblastic leukemia towards long non-coding RNAs

Kaat DurinckJoni Van der MeulenMaté OngenaertPieter-Jan VoldersAnnelynn WallaertNadine Van RoyYves BenoitBruce PoppePieter MestdaghJo Vandesompele et al.

Expanding the TLX1-regulome in T cell acute lymphoblastic leukemia towards long non-coding RNAs

Kaat DurinckJoni Van der MeulenMaté OngenaertPieter-Jan VoldersAnnelynn WallaertNadine Van RoyYves BenoitBruce PoppePieter MestdaghJo Vandesompele et al.

MiR-128 is a novel PHF6 targeting regulatory non-coding RNA acting as a T-ALL oncogene

Evelien MetsJoni Van der MeulenGert Van PeerMichael BoicePieter MestdaghTom TaghonDavid AvranBarbara De MoerlooseYves BenoitBruce Poppe et al.

The need for transparency and good practices in the qPCR literature

Stephen A BustinVladimir BenesJeremy GarsonJan HellemansJim HuggettMikael KubistaReinhold MuellerTania NolanMichael W PfafflGregory Shipley et al.

A1 Journal Article in NATURE METHODS

2012

Improved risk stratification and outcome prediction in children with average risk 1 precursor-B acute lymphoblastic leukemia using a 19-microRNA signature

Farzaneh GhazaviTim LammensStefan SuciuGenevieve LaureysMarleen BakkusAlina FersterAnne UyttebroeckPatrick LutzHélène CavéGeneviève Plat et al.

Improved risk-stratification and outcome prediction in children with average risk precursor-B acute lymphoblastic leukemia using a 19-microRNA signature

Farzaneh GhazaviTim LammensStefan SuciuGenevieve LaureysMarleen BakkusAlina FersterAnne UyttebroeckPatrick LutzHélène CavéGeneviève Plat et al.

2011

A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL)

Konstantinos J MavrakisJoni Van der MeulenAndrew L WolfeXiaoping LiuEvelien MetsTom TaghonAly A KhanManu SettyPieter RondouPeter Vandenberghe et al.

A1 Journal Article in NATURE GENETICS

A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL)

Evelien MetsJoni Van der MeulenKonstantinos J MavrakisAndrew L WolfeTom TaghonAly A KhanManu SettyXiaoping LiuPieter RondouPeter Vandenberghe et al.

Cooperative miRNA mediated FBXW7 suppression contributes to T-cell lymphoblastic leukemogenesis

Evelien MetsJoni Van der MeulenKonstantinos J MavrakisAndrew L WolfeTom TaghonAly A KhanManu SettyXiaoping LiuPeter VandenbergheEric Delabesse et al.

EVI1-mediated down regulation of MIR449A is essential for the survival of EVI1 positive leukaemic cells

An De WeerJoni Van der MeulenPieter RondouTom TaghonTorsten A KonradKatleen De PreterPieter MestdaghTom Van MaerkenNadine Van RoyMarta Jeison et al.

A1 Journal Article in BRITISH JOURNAL OF HAEMATOLOGY

Regulatory networks governed by microRNAs in T-ALL oncogenesis and normal T-cell development

Joni Van der MeulenEvelien MetsPieter MestdaghPeter PipelersTom TaghonDavid Camacho TrujilloDavid AvranGert Van PeerNadine Van RoyOlivier Thas et al.

2010

Microrna expression in pediatric precursor-B acute lymphoblastic leukemia: biology, classification and prognosis

Tim LammensBarbara De MoerlooseJonas Van BaelenJoni Van der MeulenPieter MestdaghBruno VerhasseltJan PhilippéFranki SpelemanYves Benoit

PHF6 mutations in T-cell acute lymphoblastic leukemia

Pieter Van VlierbergheTeresa PalomeroHossein KhiabanianJoni Van der MeulenMireia CastilloNadine Van RoyBarbara De MoerlooseJan PhilippéSara Gonzalez-GarciaMaria L Toribio et al.

A1 Journal Article in NATURE GENETICS

The TLX1 oncogene drives aneuploidy in T cell transformation

Kim De KeersmaeckerPedro J RealGiusy Della GattaTeresa PalomeroMaria Luisa SulisValeria ToselloPieter Van VlierbergheKelly BarnesMireia CastilloXavier Sole et al.

A1 Journal Article in NATURE MEDICINE

2009

CRYPTIC 9P24 MICRODELETIONS COVERING HSA-MIR-101-2 ARE RECURRENT IN HEMATOLOGICAL MALIGNANCIES

K van RoosbroeckI LahortigaJF FerreiroJoni Van der MeulenP VandenbergheJ CoolsFranki SpelemanP MarynenI Wlodarska

Downregulation of miR-449a is essential for the survival of EVI1 positive leukemic cells through modulation of NOTCH1 and BCL2

An De WeerPieter MestdaghKatleen De PreterJoni Van der MeulenPieter Van VlierbergheTom Van MaerkenNadine Van RoyMarta JeisonIsaac YanivBarbara Cauwelier et al.

MICRORNA SIGNATURES IN GENETIC SUBTYPES OF T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA

Joni Van der MeulenPieter Van VlierberghePieter MestdaghJo VandesompeleBruce PoppeNadine Van RoyTom TaghonJean PlumB. CauwelierDLD Selleslag et al.