Research Explorer

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Researcher

Jonathan Maelfait

31 Results

2022

Mutations in RNU7-1 weaken secondary RNA structure, induce MCP-1 and CXCL10 in CSF, and result in Aicardi-Goutières syndrome with severe end-organ involvement

Leslie NaesensJosephine NemegeerFilip RoelensLore VallaeysMarije MeuwissenKatrien JanssensPatrick VerlooBenson OgunjimiDimitri HemelsoetLevi HosteLisa RoelsMarieke De BruyneElfride De BaereJo Van DorpeAmélie DendoovenAnne SiebenGillian I. RiceTessa KerreRudi BeyaertCarolina UggentiYanick J. CrowSimon TavernierJonathan MaelfaitFilomeen Haerynck[missing] Program for Undiagnosed Rare Diseases (UD-PrOZA)

A1 Journal Article in JOURNAL OF CLINICAL IMMUNOLOGY

Reduced protection of RIPK3-deficient mice against influenza by matrix protein 2 ectodomain targeted active and passive vaccination strategies

Teodora-Eugenia OlteanLorena IbanezTatyana DivertTine YsenbaertHannelore Van EeckhoutteVera GoossensMichael SchotsaertKen BrackeBert SchepensJonathan MaelfaitNozomi TakahashiXavier SaelensPeter Vandenabeele

A1 Journal Article in CELL DEATH & DISEASE

Viral RHIM proteins antagonise necroptosis by preventing ZBP1-induced RIPK1/RIPK3 amyloid formation in human cells

Josephine NemegeerLeslie NaesensSimon VerdonckEvelien DierickKatrien StaesPeter VandenabeeleJonathan Maelfait

Viral manipulation of host cell necroptosis and pyroptosis

Simon VerdonckJosephine NemegeerPeter VandenabeeleJonathan Maelfait

A1 Journal Article in TRENDS IN MICROBIOLOGY

2021

ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation

Richard de ReuverEvelien DierickBartosz WiernickiKatrien StaesLeen SeysEllen De MeesterTuur MuyldermansAlexander BotzkiBart LambrechtFilip Van NieuwerburghPeter VandenabeeleJonathan Maelfait

A1 Journal Article in CELL REPORTS

Clinical, genetic and immunological evaluation of the type I interferonopathy Aicardi-Goutieres syndrome caused by mutations in RNU7-1

Leslie NaesensJosephine NemegeerTessa KerreRudi BeyaertSimon TavernierJonathan MaelfaitFilomeen Haerynck

GTF3A mutations in a patient with herpes simplex encephalitis reveals a novel role in viral immunity by transcribing 5S rRNA pseudogenes serving as RIG-I ligands

Leslie NaesensSantoshi MuppalaJung-Hyun LeeJosephine NemegeerDhiraj AcharyaDelfien BogaertMichiel van GentJens StaalKatrien StaesVeronique DebackerMarieke De BruyneBart LambrechtRudi BeyaertTessa KerreSimon TavernierJonathan MaelfaitMichaela GackFilomeen Haerynck

Novel mutations in RNU7-1 weaken secondary RNA structure, induce MCP-1 and CXCL10 in CSF and result in Aicardi-Goutières syndrome with severe end-organ involvement

Leslie NaesensJosephine NemegeerFilip RoelensLore VallaeysMarije MeuwissenKatrien JanssensPatrick VerlooBenson OgunjimiDimitri HemelsoetProgram for Undiagnosed Rare Diseases (UD-PrOZA)Levi HosteLisa RoelsMarieke De BruyneElfride De BaereJo Van DorpeAmélie DendoovenAnne SiebenGillian RiceTessa KerreRudi BeyaertCarolina UggentiYanick CrowSimon TavernierJonathan MaelfaitFilomeen Haerynck

Unraveling cell death modalities during influenza infection, vaccination, and cancer therapy

Teodora-Eugenia OlteanPeter VandenabeeleJonathan MaelfaitSandy Adjemian Catani

Viral dosing of influenza A infection reveals involvement of RIPK3 and FADD, but not MLKL

Teodora-Eugenia OlteanEmily Van SanTatyana DivertTom Vanden BergheXavier SaelensJonathan MaelfaitNozomi TakahashiPeter Vandenabeele

A1 Journal Article in CELL DEATH & DISEASE

2020

Nucleic acid sensors and programmed cell death

Jonathan MaelfaitLayal LiverpoolJan Rehwinkel

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

OTULIN prevents liver inflammation and hepatocellular carcinoma by inhibiting FADD- and RIPK1 kinase-mediated hepatocyte apoptosis

Lien VerboomArne MartensDario PriemEsther HosteMozes SzeHanna-Kaisa VikkulaLisette Van HoveSofie VoetJana RoelsJonathan MaelfaitLaura BongiovanniAlain de BruinCharlotte ScottYvan SaeysManolis PasparakisMathieu BertrandGeert van Loo

A1 Journal Article in CELL REPORTS

Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation

Michael DevosGiel TangheBarbara GilbertEvelien DierickMaud VerheirstraetenJosephine NemegeerRichard de ReuverSylvie LefebvreJolien De MunckJan RehwinkelPeter VandenabeeleWim DeclercqJonathan Maelfait

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

2017

Purification of cyclic GMP-AMP from viruses and measurement of its activity in cell culture

Alice MayerJonathan MaelfaitAnne BridgemanJan Rehwinkel

Bookchapter in Innate antiviral immunity : methods and protocols

RECONsidering sensing of cyclic dinucleotides

Jonathan MaelfaitJan Rehwinkel

Editorial material

Sensing of viral and endogenous RNA by ZBP1/DAI induces necroptosis

Jonathan MaelfaitLayal LiverpoolAnne BridgemanKatherine B. RaganJason W. UptonJan Rehwinkel

A1 Journal Article in EMBO JOURNAL

2016

A20 deficiency in lung epithelial cells protects against influenza A virus infection

Jonathan MaelfaitKenny RooseLars VereeckeConor Mc GuireMozes SzeMartijn SchuijsMonique WillartLorena IbanezHamida HammadBart LambrechtRudi BeyaertXavier SaelensGeert van Loo

A1 Journal Article in PLOS PATHOGENS

Optineurin deficiency in mice is associated with increased sensitivity to Salmonella but does not affect proinflammatory NF-κB signaling

Karolina SlowickaLars VereeckeConor Mc GuireMozes SzeJonathan MaelfaitAnnasaheb KolpeXavier SaelensRudi BeyaertGeert van Loo

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Restriction by SAMHD1 limits cGAS/STING-dependent innate and adaptive immune responses to HIV-1

Jonathan MaelfaitAnne BridgemanAdel BenlahrechChiara CursiJan Rehwinkel

A1 Journal Article in CELL REPORTS

2015

Viruses transfer the antiviral second messenger cGAMP between cells

A BridgemanJonathan MaelfaitT DavenneT PartridgeY PengA MayerT DongV KaeverP BorrowJ Rehwinkel

A1 Journal Article in SCIENCE

2014

Keeping your armour intact : how HIV-1 evades detection by the innate immune system : HIV-1 capsid controls detection of reverse transcription products by the cytosolic DNA sensor cGAS

Jonathan MaelfaitElena SeiradakeJan Rehwinkel

A1 Journal Article in BIOESSAYS

SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage

Ruth CliffordTania LouisPauline RobbeSam AckroydAdam BurnsAdele T TimbsGlen Wright ColopyHelene DreauFrançois SigauxJean Gabriel JuddeMargalida RotgerAmalio TelentiYea-Lih LinPhilippe PaseroJonathan MaelfaitMichalis TitsiasDena R CohenShirley J HendersonMark T RossDavid BentleyPeter HillmenAndrew PettittJan RehwinkelSamantha JL KnightJenny C TaylorYanick J CrowMonsef BenkiraneAnna Schuh

A1 Journal Article in BLOOD

2013

SAMHD1-dependent retroviral control and escape in mice

Jan RehwinkelJonathan MaelfaitAnne BridgemanRachel RigbyBruce HaywardRachel A LiberatorePaul D BieniaszGreg J TowersLuis F MoitaYanick J CrowDavid T BonthronCaetano Reis e Sousa

A1 Journal Article in EMBO JOURNAL

2012

A20 (Tnfaip3) deficiency in myeloid cells protects against influenza A virus infection

Jonathan MaelfaitKenny RoosePieter BogaertMozes SzeXavier SaelensManolis PasparakisIsabelle CarpentierGeert van LooRudi Beyaert

A1 Journal Article in PLOS PATHOGENS

Emerging role of ubiquitination in antiviral RIG-I signaling

Jonathan MaelfaitRudi Beyaert

A1 Journal Article in MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

2011

A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis

Mourad MatmatiPeggy JacquesJonathan MaelfaitEveline VerheugenMirjam KoolMozes SzeLies GeboesEls LouagieConor Mc GuireLars VereeckeYuanyuan ChuLouis BoonSteven StaelensPatrick MatthysBart LambrechtMarc Schmidt-SupprianManolis PasparakisDirk ElewautRudi BeyaertGeert van Loo

A1 Journal Article in NATURE GENETICS

A20 (TNFAIP3) deficiency in myeloid cells triggers rheumatoid arthritis

Dirk ElewautMourad MatmatiPeggy JacquesJonathan MaelfaitEveline VerheugenMirjam KoolMozes SzeLies GeboesEls LouagieConor Mc GuireLars VereeckeYuanyuan ChuSteven StaelensPatrick MatthysBart LambrechtMarc Schmidt-SupprianManolis PasparakisRudi BeyaertGeert van Loo

Signaling in antiviral immunity and its regulation by the ubiquitin-editing protein A20

Jonathan MaelfaitRudi BeyaertGeert van Loo

2010

Endoplasmic reticulum chaperone gp96 is essential for infection with vesicular stomatitis virus

Stuart BloorJonathan MaelfaitRebekka KrumbachRudi BeyaertFelix Randow

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2008

Non-apoptotic functions of caspase-8

Jonathan MaelfaitRudi Beyaert

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Stimulation of Toll-like receptor 3 and 4 induces interleukin-1β maturation by caspase-8

Jonathan MaelfaitElisabeth VercammenSophie JanssensPeter SchotteMira HaegmanStefan MagezRudi Beyaert

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE