Research Explorer

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Researcher

Jon Huyghe

Publications & Research Data

Awards & Distinctions

10 Results

2026

TAB2 controls a TAK1-independent cell death checkpoint at the level of TNFR1 complex II in the TNF pathway

Tom DelangheMike VadiAnnelore HaemsLisa WijnsInge BruggemanJon HuygheDario PriemPeter VandenabeeleMathieu Bertrand

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2025

ATG9A-mediated autophagy prevents inflammatory skin disease by limiting TNFR1-driven STING activation and ZBP1-dependent cell death

Dario PriemJon HuygheBarbara GilbertSimon VerdonckTom DelangheBruno VerstraetenEsther HostePeter VandenabeeleJonathan MaelfaitGeert van Loo et al.

A1 Journal Article in IMMUNITY

Virotrap Reveals <i>Salmonella</i> SopB as A Ubiquitinated Cargo for Host ESCRT-0

Margaux De MeyerAnnick VerheeHanna GrzesikDelphine De SutterJon HuygheLouis DelhayeTessa Van de SteeneIgor FijalkowskiVeronique JonckheereLeander Meuris et al.

2023

Cell death checkpoints in the TNF pathway

Jon HuygheDario PriemMathieu Bertrand

A1 Journal Article in TRENDS IN IMMUNOLOGY

Detoxification mechanisms in the TNF pathway

Jon HuygheMathieu BertrandDario Priem

LC3-independent autophagy is vital to prevent TNF cytotoxicity

Dario PriemJon HuygheMathieu Bertrand

A1 Journal Article in AUTOPHAGY

NINJ1 is activated by cell swelling to regulate plasma membrane permeabilization during regulated necrosis

Yves DondelingerDario PriemJon HuygheTom DelanghePeter VandenabeeleMathieu Bertrand

A1 Journal Article in CELL DEATH & DISEASE

2022

ATG9A prevents TNF cytotoxicity by an unconventional lysosomal targeting pathway.

Jon HuygheDario PriemLisette Van HoveBarbara GilbertJ FritschY UchiyamaEsther HosteGeert van LooMathieu Bertrand

A1 Journal Article in SCIENCE

2021

Antioxidant and food additive BHA prevents TNF cytotoxicity by acting as a direct RIPK1 inhibitor

Tom DelangheJon HuygheSeungheon LeeDario PriemSamya Van CoillieBarbara GilbertSze Men ChoiPeter VandenabeeleAlexei DegterevGregory D. Cuny et al.

A1 Journal Article in CELL DEATH & DISEASE

2017

Fight fire with fire : gene therapy strategies to cure HIV

Jon HuygheMagdalena SipsLinos Vandekerckhove

A1 Journal Article in EXPERT REVIEW OF ANTI-INFECTIVE THERAPY