Research Explorer

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Researcher

Jolien Vandewalle

27 Results

2022

Dimerization of the glucocorticoid receptor and its importance in (patho)physiology : a primer

Steven TimmermansJolien VandewalleClaude Libert

A1 Journal Article in CELLS

Point mutation I634A in the glucocorticoid receptor causes embryonic lethality by reduced ligand binding

Steven TimmermansNicolette J.D. VerhoogKelly Van LooverenSylviane DewaeleTino HochepiedMelanie EggermontBarbara GilbertAnne Boerema-de MunckTineke VanderhaeghenJoke Vanden BergheNatalia Garcia GonzalezJolien VandewalleYehudi BlochMathias ProvostSavvas SavvidesKarolien De BosscherWim DeclercqRobbert J. RottierAnn LouwClaude Libert

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Reprogramming of glucocorticoid receptor function by hypoxia

Tineke VanderhaeghenSteven TimmermansDeepika WattsVille PaakinahoMelanie EggermontJolien VandewalleCharlotte WallaeysLise Van WyngeneKelly Van LooverenLouise NuyttensSylviane DewaeleJoke Vanden BergheKelly LemeireJoey De BackerLaura DirkxWim Vanden BergheGuy CaljonBart GhesquiereKarolien De BosscherBen WielockxJorma J. PalvimoRudi BeyaertClaude Libert

A1 Journal Article in EMBO REPORTS

Sepsis : a failing starvation response

Jolien VandewalleClaude Libert

A1 Journal Article in TRENDS IN ENDOCRINOLOGY AND METABOLISM

miR-511 Deficiency Protects Mice from Experimental Colitis by Reducing TLR3 and TLR4 Responses via WD Repeat and FYVE-Domain-Containing Protein 1

Shafaque RahmanJolien VandewallePatricia H. P. van HamersveldCaroline VerseijdenOlaf WeltingAldo JongejanPierina CasanovaSybren L. MeijerClaude LibertTheodorus B. M. HakvoortWouter J. de JongeSigrid E. M. Heinsbroek

U Journal Article in CELLS

2021

Combined glucocorticoid resistance and hyperlactatemia contributes to lethal shock in sepsis

Jolien VandewalleSteven TimmermansVille PaakinahoLies VancraeynestLiza DewyseTineke VanderhaeghenCharlotte WallaeysLise Van WyngeneKelly Van LooverenLouise NuyttensMelanie EggermontSylviane DewaeleTiago R. VelhoLuis F. MoitaSebastian WeisChristoph SponholzLeo A. van GrunsvenMieke DewerchinPeter CarmelietKarolien De BosscherJohan Van de VoordeJorma J. PalvimoClaude Libert

A1 Journal Article in CELL METABOLISM

Macrophage miR-210 induction and metabolic reprogramming in response to pathogen interaction boost life-threatening inflammation

Federico VirgaFederica CappellessoBenoit StijlemansAnne-Theres HenzeRosa TrottaJonas Van AudenaerdeAnanda S. MirchandaniManuel A. Sanchez-GarciaJolien VandewalleFrancesca OrsoCarla Riera-DomingoAlberto GriffaCristina IvanEvelien SmitsDamya LaouiFabio MartelliLies LangoucheGreet Van den BergheOlivier FeronBart GhesquiereHans PrenenClaude LibertSarah R. WalmsleyCyril CorbetJo A. Van GinderachterMircea IvanDaniela TavernaMassimiliano Mazzone

A1 Journal Article in SCIENCE ADVANCES

The role of glucocorticoid resistance and TNFR1 signaling in sepsis

Jolien VandewalleClaude LibertKarolien De Bosscher

ZBTB32 performs crosstalk with the glucocorticoid receptor and is crucial in glucocorticoid responses to starvation

Lise Van WyngeneTineke VanderhaeghenIoanna PettaSteven TimmermansKatrien CorbeelsBart Van der SchuerenJolien VandewalleKelly Van LooverenCharlotte WallaeysMelanie EggermontSylviane DewaeleLeen CatrysseGeert van LooRudi BeyaertRoman VangoitsenhovenToshinori NakayamaJan TavernierKarolien De BosscherClaude Libert

A1 Journal Article in ISCIENCE

2020

GILZ in sepsis : 'poor is the pupil who does not surpass his master'

Jolien VandewalleClaude Libert

Editorial material

Glucocorticoids in sepsis : to be or not to be

Jolien VandewalleClaude Libert

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Glucocorticoids limit lipopolysaccharide-induced lethal inflammation by a double control system

Kelly Van LooverenSteven TimmermansTineke VanderhaeghenCharlotte WallaeysMarlies BallegeerJolien SouffriauMelanie EggermontJolien VandewalleLise Van WyngeneKarolien De BosscherClaude Libert

A1 Journal Article in EMBO REPORTS

Hepatic PPARα function and lipid metabolic pathways are dysregulated in polymicrobial sepsis

Lise Van WyngeneTineke VanderhaeghenSteven TimmermansJolien VandewalleKelly Van LooverenJolien SouffriauCharlotte WallaeysMelanie EggermontSam ErnstEvelien Van HammeAmanda GonçalvesGuy EelenAnneleen RemmerieCharlotte ScottCaroline RomboutsLynn VanhaeckeLiesbet De BusJohan DecruyenaerePeter CarmelietClaude Libert

A1 Journal Article in EMBO MOLECULAR MEDICINE

Hypoxia-inducible factors in metabolic reprogramming during sepsis

Tineke VanderhaeghenJolien VandewalleClaude Libert

A1 Journal Article in FEBS JOURNAL

Taking the STING out of sepsis?

Jolien VandewalleTineke VanderhaeghenRudi BeyaertClaude Libert

Editorial material

Zinc inhibits lethal inflammatory shock by preventing microbe-induced interferon signature in intestinal epithelium

Jolien SouffriauSteven TimmermansTineke VanderhaeghenCharlotte WallaeysKelly Van LooverenLindsy AelbrechtSylviane DewaeleJolien VandewalleEvy GoossensSerge VerbanckFilip BoyenMelanie EggermontLindsey De CommerRiet De RyckeMichiel De BruyneRaul TitoMarlies BallegeerSofie VandevyverTiago VelhoLuis Ferreira MoitaTino HochepiedKarolien De BosscherJeroen RaesFilip Van ImmerseelRudi BeyaertClaude Libert

A1 Journal Article in EMBO MOLECULAR MEDICINE

2019

A study of cecal ligation and puncture-induced sepsis in tissue-specific tumor necrosis factor receptor 1-deficient mice

Jolien VandewalleSophie SteelandSara Van RyckeghemMelanie EggermontElien Van WonterghemRoosmarijn VandenbrouckeClaude Libert

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Overexpression of Gilz protects mice against lethal septic peritonitis

Marlies BallegeerJolien VandewalleMelanie EggermontGert Van IsterdaelLien DejagerLiesbet De BusJohan DecruyenaereRoosmarijn VandenbrouckeClaude Libert

A1 Journal Article in SHOCK

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile

Karen DendonckerSteven TimmermansJolien VandewalleMelanie EggermontJoanna LempiäinenVille PaakinahoEvelien Van HammeSylviane DewaeleSofie VandevyverMarlies BallegeerJolien SouffriauLise Van WyngeneKelly Van LooverenTineke VanderhaeghenRudi BeyaertKarolien De BosscherJorma J PalvimoMarc Van MontaguClaude Libert

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2018

Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice

Marlies BallegeerKelly Van LooverenSteven TimmermansMelanie EggermontSofie VandevyverFabien Henri TheryKaren DendonckerJolien SouffriauJolien VandewalleLise Van WyngeneRiet De RyckeNozomi TakahashiPeter VandenabeeleJan TuckermannHolger M ReichardtFrancis ImpensRudi BeyaertKarolien De BosscherRoosmarijn VandenbrouckeClaude Libert

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

Reprogramming of basic metabolic pathways in microbial sepsis : therapeutic targets at last?

Lise Van WyngeneJolien VandewalleClaude Libert

A1 Journal Article in EMBO MOLECULAR MEDICINE

Simultaneous inhibition of tumor necrosis factor receptor 1 and matrix metalloproteinase 8 completely protects against acute inflammation and sepsis

Sophie SteelandSara Van RyckeghemJolien VandewalleMarlies BallegeerElien Van WonterghemMelanie EggermontJohan DecruyenaereLiesbet De BusClaude LibertRoosmarijn Vandenbroucke

A1 Journal Article in CRITICAL CARE MEDICINE

The choroid plexus epithelium as a novel player in the stomach-brain axis during Helicobacter infection

Nina GorléCaroline BlaecherEva BauwensCharysse VandendriesscheSriram BalusuJolien VandewalleCaroline Van CauwenbergheElien Van WonterghemGriet Van ImschootCheng LiuRichard DucatelleClaude LibertFreddy HaesebrouckAnnemieke SmetRoosmarijn Vandenbroucke

A1 Journal Article in BRAIN BEHAVIOR AND IMMUNITY

Therapeutic mechanisms of glucocorticoids

Jolien VandewalleAstrid LuypaertKarolien De BosscherClaude Libert

A1 Journal Article in TRENDS IN ENDOCRINOLOGY AND METABOLISM

Using the inbred mouse strain SPRET/EiJ to provide novel insights in inflammation and infection research

Steven TimmermansJolien SouffriauJolien VandewalleLise Van WyngeneKelly Van LooverenTineke VanderhaeghenClaude Libert

A1 Journal Article in MAMMALIAN GENOME

2017

Glucocorticoid receptor-mediated transactivation is hampered by Striatin-3, a novel interaction partner of the receptor

Ioanna PettaNadia BougarneJolien VandewalleLien DejagerSofie VandevyverMarlies BallegeerSofie DesmetJonathan ThommisLode De CauwerSam LievensClaude LibertJan TavernierKarolien De Bosscher

A1 Journal Article in SCIENTIFIC REPORTS

2015

Glucocorticoid-induced microRNA-511 protects against TNF by down-regulating TNFR1

Leen PuimègeFilip Van HauwermeirenSophie SteelandSara Van RyckeghemJolien VandewalleSofie LodensLien DejagerSofie VandevyverJan StaelensSteven TimmermansRoosmarijn VandenbrouckeClaude Libert

A1 Journal Article in EMBO MOLECULAR MEDICINE