Research Explorer

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Researcher

Johan Grooten

Publications & Research Data

Awards & Distinctions

149 Results

2021

Alternaria alternata and Aspergillus fumigatus mold species counteract experimental mycobacterial and allergic lung diseases through divergent innate immune mechanisms

Pauline LehebelOlivier DenisJohan GrootenWim Declercq

Aspergillus fumigatus recognition by dendritic cells negatively regulates allergic lung inflammation through a TLR2/MyD88 pathway

Pauline PercierSofie De PrinsGiresse TimaRudi BeyaertJohan GrootenMarta RomanoOlivier Denis

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

2018

Post-PEGylated and crosslinked polymeric ssRNA nanocomplexes as adjuvants targeting lymph nodes with increased cytolytic T cell inducing properties

Bo LouAns De BeuckelaerGeorge DakwarKatrien RemautJohan GrootenKevin BraeckmansBruno De GeestEnrico MastrobattistaStefaan De KokerWim E. Hennink

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes

Lien Van HoeckeSandra Van LintKenny RooseAlexander Van ParysPeter VandenabeeleJohan GrootenJan TavernierStefaan De KokerXavier Saelens

A1 Journal Article in NATURE COMMUNICATIONS

2017

Arginine-rich peptide-based mRNA nanocomplexes efficiently instigate cytotoxic T cell immunity dependent on the amphipathic organization of the peptide

Vimal Kumar UdhayakumarAns De BeuckelaerJoanne McCaffreyCian M McCruddenJonathan L KirschmanDaryll VanoverLien Van HoeckeKenny RooseKim DeswarteBruno De Geest et al.

A1 Journal Article in ADVANCED HEALTHCARE MATERIALS

Development and validation of synthetic-virus like vaccines

Vimal Kumar UdhayakumarJohan GrootenStefaan De Koker

Inflammatory monocytes regulate Th1 oriented immunity to CpG adjuvanted protein vaccines through production of IL-12

Stefaan De KokerLien Van HoeckeAns De BeuckelaerKenny RooseKim DeswarteMonique WillartPieter BogaertThomas NaessensBruno De GeestXavier Saelens et al.

A1 Journal Article in SCIENTIFIC REPORTS

Mycolates of Mycobacterium tuberculosis modulate the flow of cholesterol for bacillary proliferation in murine macrophages

Ilke VermeulenMark BairdJuma Al-DulayymiMuriel SmetJan VerschoorJohan Grooten

A1 Journal Article in JOURNAL OF LIPID RESEARCH

Tuberculosis : how different synthetic analogues of pathogen associated mycolates affect lipid homeostasis of murine host macrophages

Ilke VermeulenJan VerschoorJohan Grooten

Type I interferons modulate CD8⁺ T cell immunity to mRNA vaccines

Ans De BeuckelaerJohan GrootenStefaan De Koker

A1 Journal Article in TRENDS IN MOLECULAR MEDICINE

2016

Cholesterol-sensing liver X receptors stimulate Th2-driven allergic eosinophilic asthma in mice

Muriel SmetLien Van HoeckeAns De BeuckelaerSeppe Vander BekenThomas NaessensKarl VergoteMonique WillartBart LambrechtJan-Ake GustafssonKnut R Steffensen et al.

A2 Journal Article in IMMUNITY INFLAMMATION AND DISEASE

Coadministration of a plasmid encoding HIV-1 Gag enhances the efficacy of cancer DNA vaccines

Laure LambrichtKevin VanvarenbergAns De BeuckelaerLien Van HoeckeJohan GrootenBernard UcakarPascale LipnikNiek SandersStefan LienenklausVéronique Préat et al.

A1 Journal Article in MOLECULAR THERAPY

Engineering polymer hydrogel nanoparticles for lymph node-targeted delivery

Stefaan De KokerJivei CuiNane VanparijsLorenzo AlbertazziJohan GrootenFrank CarusoBruno De Geest

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

GM-CSF treatment prevents respiratory syncytial virus– induced pulmonary exacerbation responses in postallergic mice by stimulating alveolar macrophage maturation

Thomas NaessensBert SchepensMuriel SmetCharlotte PollardLien Van HoeckeAns De BeuckelaerMonique WillartBart LambrechtStefaan De KokerXavier Saelens et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

mRNA-based vaccines to elicit CD8⁺ T cell immunity

Ans De BeuckelaerJohan GrootenStefaan De Koker

Mycobacterium tuberculosis-associated synthetic mycolates differentially exert immune stimulatory adjuvant activity

Muriel SmetCharlotte PollardAns De BeuckelaerLien Van HoeckeSeppe Vander BekenStefaan De KokerJuma'a R Al DulayymiKris HuygenJan VerschoorMark S Baird et al.

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

pH-degradable imidazoquinoline-ligated nanogels for lymph node-focused immune activation

Lutz NuhnNane VanparijsAns De BeuckelaerLien LybaertGlenn VerstraeteKim DeswarteStefan LienenklausNikunj M ShuklaAlex CD SalyerBart Lambrecht et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

pH-Degradable mannosylated nanogels for dendritic cell targeting

Ruben De CoenNane VanparijsMartijn RisseeuwLien LybaertBenoit LouageStefaan De KokerVimal Kumar UdhayakumarJohan GrootenLeeanne TaylorNeil Ayres et al.

A1 Journal Article in BIOMACROMOLECULES

Spontaneous protein adsorption on graphene oxide nanosheets allowing efficient intracellular vaccine protein delivery

Hui LiKaat FierensZhiyue ZhangNane VanparijsMartijn SchuijsKatleen Van SteendamNatalia Feiner GraciaRiet De RyckeThomas De BeerAns De Beuckelaer et al.

A1 Journal Article in ACS APPLIED MATERIALS & INTERFACES

Type I interferons interfere with the capacity of mRNA lipoplex vaccines to elicit cytolytic T cell responses

Ans De BeuckelaerCharlotte PollardSandra Van LintKenny RooseLien Van HoeckeTom NaessensVimal Kumar UdhayakumarMuriel SmetNiek SandersStefan Lienenklaus et al.

A1 Journal Article in MOLECULAR THERAPY

Vaccination with necroptotic cancer cells induces efficient anti-tumor immunity

Tania Love AaesAgnieszka KaczmarekTinneke DelvaeyeBram De CraeneStefaan De KokerLiesbeth HeyndrickxIris DelrueJoachim TaminauBartosz WiernickiPhilippe De Groote et al.

A1 Journal Article in CELL REPORTS

2015

E-cadherin expression in macrophages dampens their inflammatory responsiveness in vitro, but does not modulate M2-regulated pathologies in vivo

Jan Van den BosscheDamya LaouiThomas NaessensHermelijn H SmitsCornelis H HokkeBenoit StijlemansJohan GrootenPatrick De BaetselierJo A Van Ginderachter

A1 Journal Article in SCIENTIFIC REPORTS

Hybrid pulmonary surfactant-coated nanogels mediate efficient in vivo delivery of siRNA to murine alveolar macrophages

Lynn De BackerThomas NaessensStefaan De KokerElisa ZagatoJo DemeesterJohan GrootenStefaan De SmedtKoen Raemdonck

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Neutralizing TNFα restores glucocorticoid sensitivity in a mouse model of neutrophilic airway inflammation

Lien DejagerKaren DendonckerMelanie EggermontJolien SouffriauFilip Van HauwermeirenMonique WillartElien Van WonterghemThomas NaessensMarlies BallegeerSofie Vandevyver et al.

A1 Journal Article in MUCOSAL IMMUNOLOGY

The site of administration influences both the type and the magnitude of the immune response induced by DNA vaccine electroporation

Gaëlle VandermeulenKevin VanvarenbergAns De BeuckelaerStefaan De KokerLaure LambrichtCatherine UyttenhoveAnca ReschnerAlain VanderplasschenJohan GrootenVéronique Préat

A1 Journal Article in VACCINE

2014

Boosting in planta production of antigens derived from the porcine reproductive and respiratory syndrome virus (PRRSV) and subsequent evaluation of their immunogenicity

Robin PironStefaan De KokerAnnelies De PaepeJulie GoossensJohan GrootenHans NauwynckAnna Depicker

A1 Journal Article in PLOS ONE

Cholesterol-sensing liver X receptors and mycolic acid bio-lipids at the crossroads of lipid metabolism and inflammation

Muriel SmetJohan Grooten

Nanoporous hydrogen bonded polymeric microparticles: facile and economic production of cross presentation promoting vaccine carriers

Marijke DierendonckKaat FierensRiet De RyckeLien LybaertSamarendra MajiZhiyue ZhangQilu ZhangRichard HoogenboomBart LambrechtJohan Grooten et al.

A1 Journal Article in ADVANCED FUNCTIONAL MATERIALS

Nanoporous polyelectrolyte vaccine microcarriers: a formulation platform for enhancing humoral and cellular immune responses

Stefaan De KokerKaat FierensMarijke DierendonckRiet De RyckeBart LambrechtJohan GrootenJean Paul RemonBruno De Geest

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

2013

Challenges and advances towards the rational design of mRNA vaccines

Charlotte PollardStefaan De KokerXavier SaelensGuido VanhamJohan Grooten

A1 Journal Article in TRENDS IN MOLECULAR MEDICINE

Evaluation of CD8⁺ T cell responses upon mRNA vaccination and the implication of type I IFN signaling

Charlotte PollardJohan GrootenStefaan De KokerGuido Vanham

Lipoplexes carrying mRNA encoding Gag protein modulate dendritic cells to stimulate HIV-specific immune responses

Winni De HaesJoanna RejmanCharlotte PollardCéline MerlinMarc VekemansEric FlorenceStefaan De SmedtJohan GrootenGuido VanhamStefaan De Koker et al.

A1 Journal Article in NANOMEDICINE

M2e-displaying virus-like particles with associated RNA promote T helper 1 type adaptive immunity against influenza A

Lorena IbanezKenny RooseMarina De FiletteMichael SchotsaertJessica De SloovereStefan RoelsCharlotte PollardBert SchepensJohan GrootenWalter Fiers et al.

A1 Journal Article in PLOS ONE

Screening of the vascular endothelial growth factor family in human colon cancer

Sarah PringelsJohan Grooten

Type I IFN counteracts the induction of antigen-specific immune responses by lipid-based delivery of mRNA vaccines

Charlotte PollardJoanna RejmanWinni De HaesBernard VerrierEllen Van GulckThomas NaessensStefaan De SmedtPieter BogaertJohan GrootenGuido Vanham et al.

A1 Journal Article in MOLECULAR THERAPY

2012

Clinical procedure for colon carcinoma tissue sampling directly affects the cancer marker-capacity of VEGF family members

Sarah PringelsNancy Van DammeBram De CraenePiet PattynWim CeelenMarc PeetersJohan Grooten

A1 Journal Article in BMC CANCER

Functional dynamics of resident alveolar macrophages in a mouse model of allergic asthma

Thomas NaessensJohan Grooten

IL-15 augments TCR-induced CD4⁺ T cell expansion in vitro by inhibiting the suppressive function of CD25High CD4⁺ T cells

Tom Van BelleHans DoomsTom BoonefaesXiao-Qing WeiGeorges LeclercqJohan Grooten

A1 Journal Article in PLOS ONE

Innate imprinting of murine resident alveolar macrophages by allergic bronchial inflammation causes a switch from hypoinflammatory to hyperinflammatory reactivity

Thomas NaessensSeppe Vander BekenPieter BogaertNico Van RooijenStefan LienenklausSiegfried WeissStefaan De KokerJohan Grooten

A1 Journal Article in AMERICAN JOURNAL OF PATHOLOGY

Mycobacterium tuberculosis bio-lipid mycolic acid and mammalian cholesterol-sensor liver X receptor in airway immunity

Seppe Vander BekenJohan Grooten

Polyelectrolyte LbL microcapsules versus PLGA microparticles for immunization with a protein antigen

Marie-Luce De TemmermanJoanna RejmanRoosmarijn VandenbrouckeStefaan De KokerClaude LibertJohan GrootenJo DemeesterBruno GanderStefaan De Smedt

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Polymeric multilayer capsule-mediated vaccination induces protective immunity against cancer and viral infection

Bruno De GeestMonique WillartHamida HammadBart LambrechtCharlotte PollardPieter BogaertMarina De FiletteXavier SaelensChris VervaetJean Paul Remon et al.

A1 Journal Article in ACS NANO

Spatiotemporal autophagic degradation of oxidatively damaged organelles after photodynamic stress is amplified by mitochondrial reactive oxygen species

Noemi RubioIsabelle CoupienneEmmanuel Di ValentinIngeborg HeirmanJohan GrootenJacques PiettePatrizia Agostinis

A1 Journal Article in AUTOPHAGY

Surface-engineered polyelectrolyte multilayer capsules: synthetic vaccines mimicking microbial structure and function

Bruno De GeestMonique WillartBart LambrechtCharlotte PollardChris VervaetJean Paul RemonJohan GrootenStefaan De Koker

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Towards understanding the functional diversity of cell wall mycolic acids of Mycobacterium tuberculosis

Jan A VerschoorMark S BairdJohan Grooten

A1 Journal Article in PROGRESS IN LIPID RESEARCH

2011

Designing polymeric particles for antigen delivery

Stefaan De KokerBart LambrechtMonique WillartYvette van KooykJohan GrootenChris VervaetJean Paul RemonBruno De Geest

A1 Journal Article in CHEMICAL SOCIETY REVIEWS

Do-it-yourself: construction of a custom cDNA macroarray platform with high sensitivity and linear range

Tom BoonefaesErica HouthuysRafael Van den BerghSeppe Vander BekenGeert RaesPeter BrouckaertP De BaetselierJohan Grooten

A1 Journal Article in BMC BIOTECHNOLOGY

Inflammatory signatures for eosinophilic vs. neutrophilic allergic pulmonary inflammation reveal critical regulatory checkpoints

Pieter BogaertThomas NaessensStefaan De KokerBenoit HennuyJonathan HachaMuriel SmetDidier CataldoEmmanuel Di ValentinJacques PietteKurt Tournoy et al.

A1 Journal Article in AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Lyophilization of protein-loaded polyelectrolyte microcapsules

Marie-Luce De TemmermanJoanna RejmanJohan GrootenThomas De BeerChris VervaetJo DemeesterStefaan De Smedt

A1 Journal Article in PHARMACEUTICAL RESEARCH

Molecular structure of the Mycobacterium tuberculosis virulence factor, mycolic acid, determines the elicited inflammatory pattern

Seppe Vander BekenJuma'a R Al DulayymiThomas NaessensGani KozaMax Maza-IglesiasRichard RowlesCornelia TheunissenJelle De MedtsEllen LanckackerMark S Baird et al.

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Polymeric multilayer capsules delivering biotherapeutics

Stefaan De KokerLiesbeth De CockPilar Rivera-GilWolfgang J ParakRachel Auzély VeltyChris VervaetJean Paul RemonJohan GrootenBruno De Geest

A1 Journal Article in ADVANCED DRUG DELIVERY REVIEWS

Single-step formation of degradable intracellular biomolecule microreactors

Marijke DierendonckStefaan De KokerRiet De RyckePieter BogaertJohan GrootenChris VervaetJean Paul RemonBruno De Geest

A1 Journal Article in ACS NANO

2010

A single step process for the synthesis of antigen laden thermosensitive microparticles

Bruno De GeestStefaan De KokerYves GonnissenLiesbeth De CockJohan GrootenJean Paul RemonChris Vervaet

A1 Journal Article in SOFT MATTER

Biodegradable polyelectrolyte microcapsules: antigen delivery tools with Th17 skewing activity after pulmonary delivery

Stefaan De KokerThomas NaessensBruno De GeestPieter BogaertJo DemeesterStefaan De SmedtJohan Grooten

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Facile two-step synthesis of porous antigen-loaded degradable polyelectrolyte microspheres

Marijke DierendonckStefaan De KokerClaude CuvelierJohan GrootenChris VervaetJean Paul RemonBruno De Geest

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

PH1-derived bivalent bibodies and trivalent tribodies bind differentially to shed and tumour cell-associated MUC1

Steve SchoonoogheIngrid BurvenichLiesbet VervoortFilip De VosNico MertensJohan Grooten

A1 Journal Article in PROTEIN ENGINEERING DESIGN & SELECTION

Polyelectrolyte capsules-containing HIV-1 p24 and poly I:C modulate dendritic cells to stimulate HIV-1-specific immune responses

Winni De HaesStefaan De KokerCharlotte PollardDerek AtkinsonErika VliegheJessy HosteJoanna RejmanStefaan De SmedtJohan GrootenGuido Vanham et al.

A1 Journal Article in MOLECULAR THERAPY

Polymeric multilayer capsules in drug delivery

Liesbeth De CockStefaan De KokerBruno De GeestJohan GrootenChris VervaetJean Paul RemonGleb B SukhorukovMaria N Antipina

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure-function relationships of the antigenicity of mycolic acids in tuberculosis patients

Mervyn BeukesYolandy LemmerMadrey DeyselR Al Dulayymi Juma'aS Baird MarkGani KozaM Iglesias MaximilianoR Rowles RichardCornelia TheunissenJohan Grooten et al.

A1 Journal Article in CHEMISTRY AND PHYSICS OF LIPIDS

Transcriptome analysis of monocyte-HIV interactions

Rafael Van den BerghEric FlorenceErika VliegheTom BoonefaesJohan GrootenErica HouthuysHuyen Thi Thanh TranYoussef GaliPatrick De BaetselierGuido Vanham et al.

A1 Journal Article in RETROVIROLOGY

2009

Alternatively activated macrophages engage in homotypic and heterotypic interactions through IL-4 and polyamine-induced E-cadherin/catenin complexes

J Van den BosschePieter BogaertJolanda van HengelChris GuerinGeert BerxK MovahediR Van den BerghA Pereira-FernandesJMC GeunsH Pircher et al.

A1 Journal Article in BLOOD

Efficient production of human bivalent and trivalent anti-MUC1 Fab-scFv antibodies in Pichia pastoris

Steve SchoonoogheVladimir KaigorodovMonika ZawiszaCaroline DumolynJurgen HaustraeteJohan GrootenNico Mertens

A1 Journal Article in BMC BIOTECHNOLOGY

Liver X receptors contribute to the protective immune response against Mycobacterium tuberculosis in mice

Hannelie KorfSeppe Vander BekenMarta RomanoKnut SteffensenBenoit StijlemansJan-Ake GustafssonJohan GrootenKris Huygen

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

New asthma biomarkers: lessons from murine models of acute and chronic asthma

Emmanuel Di ValentinCeline CrahayNancy GarbackiBenoit HennuyMaud GuedersAgnes NoelJean-Michel FoidartJohan GrootenAlain ColigeJacques Piette et al.

A1 Journal Article in AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Polyelectrolyte Microcapsules as Antigen Delivery Vehicles To Dendritic Cells: Uptake, Processing, and Cross-Presentation of Encapsulated Antigens

Stefaan De KokerBruno De GeestSatwinder SinghRiet De RyckeThomas NaessensYvette Van KooykJo DemeesterStefaan De SmedtJohan Grooten

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The first unique synthetic mycobacterial cord factors

JR Al DulayymiMS BairdM Maza-IglesiasSeppe Vander BekenJohan Grooten

A1 Journal Article in TETRAHEDRON LETTERS

Where asthma and hypersensitivity pneumonitis meet and differ: noneosinophilic severe asthma

Pieter BogaertKurt TournoyThomas NaessensJohan Grooten

A1 Journal Article in American Journal of Pathology

2008

Cholesteroid nature of free mycolic acids from M. tuberculosis

Yolandy BenadieMadrey DeyselD. Gilbert R. SikoVanessa V. RobertsSandra Van WyngaardtSimon T. ThanyaniGianna SekankaAnnemieke M.C. Ten BokumLynne A. CollettJohan Grooten et al.

A1 Journal Article in CHEMISTRY AND PHYSICS OF LIPIDS

Polyelectrolyte microcapsules for antigen delivery

Stefaan De KokerJohan GrootenStefaan De SmedtNico Mertens

2007

Mycolic acids for the control of tuberculosis

G SEKANKAM BAIRDD MINNIKINJohan Grooten

A1 Journal Article in EXPERT OPINION ON THERAPEUTIC PATENTS

2006

Animal models of allergen-induced tolerance in asthma: are T-regulatory-1 cells (Tr-1) the solution for T-helper-2 cells (Th-2) in asthma?

Kurt TournoyChris Van HoveJohan GrootenK MOERLOOSEGuy BrusselleGuy Joos

A1 Journal Article in CLINICAL AND EXPERIMENTAL ALLERGY

Blocking tumor cell eicosanoid synthesis by GPx4 impedes tumor growth and malignancy

Ingeborg HeirmanDaisy GinnebergeB BRIGELIUS-FLOHEN HENDRICKXP AGOSTINISPeter BrouckaertPieter RottiersJohan Grooten

A1 Journal Article in FREE RADICAL BIOLOGY AND MEDICINE

IL-15 augments CD4+T-cell proliferation by inhibiting the suppressive function of CD25HighCD4+regulatory T-cells

Tom Van BelleTom BoonefaesGeorges LeclercqJohan Grooten

Macrophage reprogramming by mycolic acid promotes a tolerogenic response in experimental asthma

Johanna KorfGwenda PynaertKurt TournoyTom BoonefaesA VAN OOSTERHOUTDaisy GinnebergeAnuschka HaegemanJA VERSCHOORP DE BAETSELIERJohan Grooten

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Role of endoplasmic reticulum depletion and multidomain proapoptotic BAX and BAK proteins in shaping cell death after hypericin-mediated photodynamic therapy

E BUYTAERTG CALLEWAERTN HENDRICKXL SCORRANOD HARTMANNL MISSIAENJR VANDENHEEDEIngeborg HeirmanJohan GrootenP AGOSTINIS

A1 Journal Article in FASEB JOURNAL

2005

CD3 x CD28 cross-interacting bispecific antibodies improve tumor cell dependent T-cell activation

An WillemsSteve SchoonoogheDominique EeckhoutGeert De JaegerJohan GrootenNico Mertens

A1 Journal Article in CANCER IMMUNOLOGY IMMUNOTHERAPY

Enhancement of polymethacrylate-mediated gene delivery by Penetratin

Bart ChristiaensPeter DubruelJohan GrootenMarc GoethalsJoël VandekerckhoveEtienne SchachtMarie Rosseneu

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

IL-15 and IL-15R alpha in CD4(+) T cell immunity

Tom Van BelleJohan Grooten

A1 Journal Article in ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Lipo-protein I, a TLR2/4 ligand modulates Th2-driven allergic immune responses

H REVETSGwenda PynaertJohan GrootenP DE BAETSELIER

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Lysophosphatidic acid affinity chromatography reveals pyruvate kinase as a specific LPA-binding protein

S DESMARETL QIANBerlinda VanlooKris MeerschaertJozef Van DammeJohan GrootenJoël VandekerckhoveGD PRESTWICHJan Gettemans

A1 Journal Article in BIOLOGICAL CHEMISTRY

Macrophage galactose-type C-type lectins as novel markers for alternatively activated macrophages elicited by parasitic infections and allergic airway inflammation

G RAESL BRYSBK DAHALJ BRANDTJohan GrootenF BROMBACHERG VANHAMW NOELPieter BogaertTom Boonefaes et al.

A1 Journal Article in JOURNAL OF LEUKOCYTE BIOLOGY

The Mycobacterium tuberculosis cell wall component mycolic acid elicits pathogen-associated host innate immune responses

Johanna KorfA STOLTZJ VERSCHOORP DE BAETSELIERJohan Grooten

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Tumor cell eicosanoids promote tumor growth, metastasis and escape from angiodestructive tumor therapy

I HEIRMANDaisy GinnebergeR BRIGELIUS-FLOHEN HENDRICKXP AGOSTINISP ROTTIERSJohan Grooten

2004

Buffering properties of cationic polymethacrylates are not the only key to successful gene delivery

Peter DubruelBart ChristiaensMaryvonne RosseneuJoël VandekerckhoveJohan GrootenVera GoossensEtienne Schacht

A1 Journal Article in BIOMACROMOLECULES

Cytoglobin expression is upregulated in all tissues upon hypoxia: an in vitro and in vivo study by quantitative real-time PCR

E FordelE GeuensSylvia DewildePieter RottiersP CarmelietJohan GrootenLuc Moens

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Enhancement of polymethacrylate-mediated gene delivery by penetratin

Peter DubruelBart ChristiaensJohan GrootenMarc GoethalsJoël VandekerckhoveEtienne SchachtMarie Rosseneu

Membrane interaction and cellular internalization of penetratin peptides

Bart ChristiaensJohan GrootenM REUSENSA JOLIOTMarc GoethalsJoël VandekerckhoveA PROCHIANTZMaryvonne Rosseneu

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

New strategies in polypeptide and antibody synthesis: An overview

Nico MertensF DEVOSJ LEls Van DeynseAn WillemsSteve SchoonoogheIngrid BurvenichStefaan De KokerDominique VliegheJohan Grooten et al.

A1 Journal Article in CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Phosphorylation by protein kinase CK2 modulates the activity of the ATP binding cassette A1 transporter

Stein RoosbeekFrank PeelmanAnnick VerheeChristine LabeurH CASTERMarc LensinkC CIRULLIJohan GrootenC COCHETJoël Vandekerckhove et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Response of TNF-hyporesponsive SPRET/Ei mice in models of inflammatory disorders

Jan StaelensLeen PuimègeTina MahieuGwenda PynaertTino HochepiedAnnelies VandenabeeleJohan GrootenDimitris KontoyiannisFrans Van RoyGeorge Kollias et al.

A1 Journal Article in MAMMALIAN GENOME

2003

Airway IgG counteracts specific and bystander allergen-triggered pulmonary inflammation by a mechanism dependent on Fc gamma R and IFN-gamma

S SEHRAGwenda PynaertKurt TournoyAnuschka HaegemanP MATTHYSY TAGAWARomain PauwelsJohan Grooten

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Antigen presentation by local macrophages promotes nonallergic airway responses in sensitized mice

Gwenda PynaertPieter RottiersAnuschka HaegemanSarita SehraTom Van BelleJohanna KorfJohan Grooten

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Eicosanoid mediators in health, inflammation and cancer.

Ingeborg HeirmanJohan Grooten

Bookchapter in Recent Research Developments in Cell Biology

Optimizing expression and purification from cell culture medium of trispecific recombinant antibody derivatives

An WillemsJ LSteve SchoonoogheJohan GrootenNico Mertens

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

2002

Induction of IL-15 by TCR/CD3 aggregation depends on IFN-gamma and protects against apoptosis of immature thymocytes in vivo.

P MATTHYSHans DoomsPieter RottiersT MITERAL OVERBERGHGeorges LeclercqA BILLIAUJohan Grooten

A1 Journal Article in CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Regulation of T-cell life and death in the periphery.

Hans DoomsTom Van BelleJohan Grooten

Bookchapter in Recent Research Developments in Immunology, Research Signpost, 2002. - ISBN 81-7736-142-2

Tumor necrosis factor-induced modulation of glyoxalase I activities through phosphorylation by PKA results in cell death and is accompanied by the formation of a specific methyl glyoxal-derived AGE.

Franky Van HerrewegheJQ MAOF CHAPLENJohan GrootenKris GevaertJoël VandekerckhoveKatia Vancompernolle

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2001

A new model for intermediate molecular weight recombinant bispecific and trispecific antibodies by efficient heterodimerization of single chain variable domains through fusion to a Fab-chain.

Reinhilde SchoonjansAn WillemsSteve SchoonoogheJ LEOENJohan GrootenNico Mertens

A1 Journal Article in BIOMOLECULAR ENGINEERING

Death receptor-induced apoptotic and necrotic cell death: differential role of caspases and mitochondria.

Geertrui DeneckerD VERCAMMENMargino SteemansTom Vanden BergheGreet BrouckaertGeert van LooB ZHIVOTOVSKYWalter FiersJohan GrootenWim Declercq et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

New recombinant bi- and trispecific antibody derivatives

Nico MertensReinhilde SchoonjansAn WillemsSteve SchoonoogheJ LJohan Grooten

2000

Efficient heterodimerization of recombinant bi- and trispecific antibodies.

Reinhilde SchoonjansAn WillemsJohan GrootenNico Mertens

A1 Journal Article in BIOSEPARATION

Fab chains as an efficient heterodimerization scaffold for the production of recombinant bispecific and trispecific antibody derivatives.

Reinhilde SchoonjansAn WillemsSteve SchoonoogheWalter FiersJohan GrootenNico Mertens

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Interleukin-15 redirects the outcome of a tolerizing T-cell stimulus from apoptosis to anergy.

Hans DoomsTom Van BelleMarjory DesmedtPieter RottiersJohan Grooten

A1 Journal Article in BLOOD

Macrophages present pinocytosed exogenous antigen via MHC class I whereas antigen ingested by receptor-mediated endocytosis is presented via MHC class II.

MP PEPPELENBOSCHMarjory DesmedtGwenda PynaertSJH VAN DEVENTERJohan Grooten

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Phosphatidyl serine exposure during apoptosis precedes release of cytochrome c and decrease in mitochondrial transmembrane potential.

Geertrui DeneckerHans DoomsGeert van LooD VERCAMMENJohan GrootenWalter FiersWim DeclercqPeter Vandenabeele

A1 Journal Article in FEBS LETTERS

Role of reactive oxygen species in tumor necrosis factor toxicity

Vera GoossensKurt De VosDominique VercammenMargino SteemansKatia VancompernolleWalter FiersPeter VandenabeeleJohan Grooten

Bookchapter in Antioxidant and redox regulation of genes

Tumor necrosis factor induces hyperphosphorylation of kinesin light chain and inhibits kinesin-mediated transport of mitochondria.

Kurt De VosF SEVERINF VAN HERREWEGHEK VANCOMPERNOLLEVera GoossensA HYMANJohan Grooten

A1 Journal Article in JOURNAL OF CELL BIOLOGY

Tumor necrosis factor-induced microtubule stabilization mediated by hyperphosphorylated oncoprotein 18 promotes cell death.

K VANCOMPERNOLLETom BoonefaesM MANNWalter FiersJohan Grooten

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

1999

Cysteinyl leukotrienes mediate histamine hypersensitivity ex vivo by increasing histamine receptor numbers.

Gwenda PynaertJohan GrootenSJH VAN DEVENTERMP PEPPELENBOSCH

A1 Journal Article in MOLECULAR MEDICINE

Lipopolysaccharide regulates macrophage fluid phase pinocytosis via CD14-dependent and CD14-independent pathways.

MP PEPPELENBOSCHMarjory DesmedtT TEN HOVESJH VAN DEVENTERJohan Grooten

A1 Journal Article in BLOOD

Multiple signal transduction pathways regulate TNF-induced actin reorganization in macrophages: Inhibition of Cdc42-mediated filopodium formation by TNF.

M PEPPELENBOSCHElke BooneGE JONESSJH VAN DEVENTERGuy HaegemanWalter FiersJohan GrootenAJ RIDLEY

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Redox regulation of TNF signaling.

Vera GoossensKurt De VosD VERCAMMENMargino SteemansK VANCOMPERNOLLEWalter FiersPeter VandenabeeleJohan Grooten

A1 Journal Article in BIOFACTORS

Regulation of tumor necrosis factor-induced, mitochondria- and reactive oxygen species-dependent cell death by the electron flux through the electron transport chain complex I

Vera GoossensGeert StangéKATHLEEN MOENSDaniel PipeleersJohan Grooten

A2 Journal Article in Antioxidants & Redox Signaling

Tumoral environment triggers transcript anomalies in established tumors : induction of altered gene expression and of aberrant, truncated and B2 repeat-containing gene transcripts

Pieter RottiersMarjory DesmedtHans DoomsRoland ContrerasJohan Grooten

A2 Journal Article in NEOPLASIA

1998

A caspase-activated factor (CAF) induces mitochondrial membrane depolarization and cytochrome c release by a nonproteolytic mechanism.

Margino SteemansVera GoossensMarc Van De CraenF VAN HERREWEGHEKatia VancompernolleKurt De VosPeter VandenabeeleJohan Grooten

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Atractyloside-induced release of cathepsin B, a protease with caspase-processing activity.

Katia VancompernolleF VAN HERREWEGHEGwenda PynaertMarc Van De CraenKurt De VosN TOTTYA STERLINGWalter FiersPeter VandenabeeleJohan Grooten

A1 Journal Article in FEBS LETTERS

Cathepsin B-mediated activation of the proinflammatory caspase-11

Peter SchotteWim Van CriekingeMarc Van De CraenGeert van LooMarjory DesmedtJohan GrootenMaria CornelissenLeo De RidderJoël VandekerckhoveWalter Fiers et al.

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Differentiation of EL4 lymphoma cells by tumoral environment is associated with inappropriate expression of the large chondroitin sulfate proteoglycan PG-M and the tumor-associated antigen HTgp-175.

Pieter RottiersT VERFAILLIERoland ContrerasH REVETSMarjory DesmedtH DOOMSWalter FiersJohan Grooten

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

Induction of unresponsiveness to tumor necrosis factor (TNF) after autocrine TNF expression requires TNF membrane retention.

Els DecosterB VANHAESEBROECKElke BooneS PLAISANCEKurt De VosGuy HaegemanJohan GrootenWalter Fiers

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor.

Dominique VercammenRudi BeyaertGeertrui DeneckerVera GoossensGeert van LooWim DeclercqJohan GrootenWalter FiersPeter Vandenabeele

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Macrophages induce cellular immunity by activating Th1 cell responses and suppressing Th2 cell responses.

Marjory DesmedtP ROTTIERSH DOOMSWalter FiersJohan Grooten

A1 Journal Article in JOURNAL OF IMMUNOLOGY

pH-dependent aggregation and secretion of soluble monomeric influenza hemagglutinin.

Peter VanlandschootEls BeirnaertJohan GrootenWilly Min JouWalter Fiers

A1 Journal Article in ARCHIVES OF VIROLOGY

Quiescence-inducing and antiapoptotic activities of IL-15 enhance secondary CD4(+) T cell responsiveness to antigen.

B DOOMSMarjory DesmedtS VANCAENEGHEMPieter RottiersVera GoossensWalter FiersJohan Grooten

A1 Journal Article in JOURNAL OF IMMUNOLOGY

The 55-kDa tumor necrosis factor receptor induces clustering of mitochondria through its membrane-proximal region.

Kurt De VosVera GoossensElke BooneDominique VercammenK VANCOMPERNOLLEPeter VandenabeeleGuy HaegemanWalter FiersJohan Grooten

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

1997

Differential role of calcium in tumour necrosis factor-mediated apoptosis and secretion of granulocyte-macrophage colony-stimulating factor in a T cell hybridoma.

Geertrui DeneckerPeter VandenabeeleJohan GrootenLC PENNINGWim DeclercqRudi BeyaertWA BUURMANWalter Fiers

A1 Journal Article in CYTOKINE

Tumour necrosis factor: intracellular mechanism of action

Walter FiersRudi BeyaertElke BooneWim DeclercqEls DecosterDirk De ValckVera GoossensJohan GrootenGuy HaegemanKaren Heyninck et al.

Bookchapter in HIV and cytokines

1996

The oxidative metabolism of glutamine - A modulator of reactive oxygen intermediate-mediated cytotoxicity of tumor necrosis factor in L929 fibrosarcoma cells.

Vera GoossensJohan GrootenWalter Fiers

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

TNF-induced intracellular signaling leading to gene induction or to cytotoxicity by necrosis or by apoptosis.

Walter FiersRudi BeyaertElke BooneSigrid CornelisWim DeclercqEls DecosterGeertrui DeneckerBart DepuydtDirk De ValckG DEWILDE et al.

A1 Journal Article in JOURNAL OF INFLAMMATION

1995

Both TNF receptors are required for TNF-mediated induction of apoptosis in PC60 cells

Peter VandenabeeleWim DeclercqBart VanhaesebroeckJohan GrootenWalter Fiers

A2 Journal Article in J. Immunol.. 154, pp. 2904-2913

BOTH TNF RECEPTORS ARE REQUIRED FOR TNF-MEDIATED INDUCTION OF APOPTOSIS IN PC60 CELLS.

Peter VandenabeeleWim DeclercqBart VanhaesebroeckJohan GrootenWalter Fiers

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Cytotoxicity in L929 murine fibrosarcoma cells after triggering of transfected human p75 tumour-necrosis-factor (TNF) receptor is mediated by endogenous murine TNF.

D VERCAMMENPeter VandenabeeleWim DeclercqM VANDECRAENJohan GrootenWalter Fiers

A1 Journal Article in CYTOKINE

Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity.

V GOOSSENSJohan GrootenK DEVOSWalter Fiers

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation and biological characterization of membrane-bound, uncleavable murine tumor-necrosis factor.

Els DecosterBart VanhaesebroeckPeter VandenabeeleJohan GrootenWalter Fiers

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Involvement of IFN-γ in Bacillus Calmette-Guérin-induced but not in tumor-induced sensitization to TNF-induced lethality

Anje CauwelsPeter BrouckaertJohan GrootenSui HuangMichel AguetWalter Fiers

A1 Journal Article in JOURNAL OF IMMUNOLOGY

1994

FUNCTIONAL REQUIREMENT OF THE 2 TNF RECEPTORS FOR INDUCTION OF APOPTOSIS IN PC60 CELLS AND THE ROLE OF MITOCHONDRIA IN TNF-INDUCED CYTOTOXICITY.

Peter VandenabeeleV GOOSSENSRudi BeyaertWim DeclercqJohan GrootenB VANHAESEBROECKM VANDECRAEND VERCAMMENB DEPUYDTG DENECKER et al.

A1 Journal Article in CIRCULATORY SHOCK

1993

CELL-MEMBRANE PERMEABILIZATION AND CELLULAR COLLAPSE, FOLLOWED BY LOSS OF DEHYDROGENASE-ACTIVITY - EARLY EVENTS IN TUMOR NECROSIS FACTOR-INDUCED CYTOTOXICITY.

Johan GrootenV GOOSSENSBart VanhaesebroeckWalter Fiers

A1 Journal Article in CYTOKINE

Effect of bcl-2-proto-oncogene expression on cellular sensitivity to tumor necrosis factor-mediated cytotoxicity.

Bart VanhaesebroeckJC REEDD DEVALCKJohan GrootenT MIYASHITAS TANAKARudi BeyaertFrans Van RoyWalter Fiers

A1 Journal Article in ONCOGENE

INCREASED IL-6 PRODUCTION AND IL-6-MEDIATED IG SECRETION IN MURINE HOST-VS-GRAFT DISEASE.

Peter VandenabeeleD ABRAMOWICZD BERUSJ VANDERHEYDENJohan GrootenV DONCKIEREL HOOGHEPETERSM GOLDMANWalter Fiers

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Two pathways of tumor necrosis factor signal transduction: in vitro and in vivo implications

Walter FiersRudi BeyaertPeter BrouckaertAnje CauwelsWim DeclercqDirk De ValckB EveraerdtVera GoossensJohan GrootenGuy Haegeman et al.

1992

Functional characterization of the human tumor necrosis factor receptor p75 in a transfected rat/mouse T cell hybridoma

Peter VandenabeeleWim DeclercqDominique VercammenMarc Van De CraenJohan GrootenHansruedi LoetscherManfred BrockhausWerner LesslauerWalter Fiers

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Tumor necrosis factor : mechanism of action and its potential for anticancer therapy

W HersRudi BeyaertPeter BrouckaertEls DecosterDirk De ValckB EveraerdtJohan GrootenAnne LenaertsClaude LibertK Schulze-Osthoff et al.

Tumor-necrosis-factor : mechanism of action at the molecular, cellular and in vivo level

Walter FiersRudi BeyaertPeter BrouckaertEls DecosterDirk De ValckBart EveraerdtJohan GrootenAnne LenaertsClaude LibertK. Schulzeosthoff et al.

1991

Expression of the tumor necrosis factor gene in tumor cells correlates with reduced tumorigenicity and reduced invasiveness in vivo

Bart VanhaesebroeckMarcus MareelFrans Van RoyJohan GrootenWalter Fiers

A1 Journal Article in CANCER RESEARCH

1990

IL-4 acts synergistically on the IL-2 response of an autoreactive T-cell clone ; synergism correlates with increased intracellular IL-2, but not with a modified IL-2 receptor expression

Peter VandenabeeleJohan GrootenWalter Fiers

A1 Journal Article in CELLULAR IMMUNOLOGY

Tumor-necrosis-factor : mechanism of action at the molecular, cellular and in vivo level

Walter FiersRudi BeyaertPeter BrouckaertBart EveraerdtJohan GrootenAnne LenaertsClaude LibertP. SuffysNozomi TakahashiJan Tavernier et al.

A1 Journal Article in SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

1989

Acquisition by the murine host of responsiveness toward various neoplastic cell lines, but not toward self, through adoptive transfer of a helper T-lymphocyte clone with antiself specificity

Johan GrootenWalter Fiers

A1 Journal Article in CANCER RESEARCH

An ongoing in vivo immune response affects the abundancy and differentiation of lymphokine-activated killer cell precursors, but does not influence their broad spectrum target reactivity

Bart VanhaesebroeckJohan GrootenWalter Fiers

A1 Journal Article in JOURNAL OF IMMUNOLOGY

1987

Alloinduced suppression and cytotoxicity: two functions of a single cell

Geert Leroux-RoelsJohan GrootenWalter Fiers

A1 Journal Article in IMMUNOLOGY LETTERS

Specific suppression elicited by EL4 lymphoma cells in syngeneic mice : specificity includes self-antigens on EL4

Johan GrootenGeert Leroux-RoelsWalter Fiers

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY