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Researcher
Johan Grooten
Profile
Projects
Publications
Activities
Awards & Distinctions
148
Results
2021
Alternaria alternata and Aspergillus fumigatus mold species counteract experimental mycobacterial and allergic lung diseases through divergent innate immune mechanisms
Pauline Lehebel
Olivier Denis
Johan Grooten
Wim Declercq
Dissertation
2021
Aspergillus fumigatus recognition by dendritic cells negatively regulates allergic lung inflammation through a TLR2/MyD88 pathway
Pauline Percier
Sofie De Prins
Giresse Tima
Rudi Beyaert
Johan Grooten
Marta Romano
Olivier Denis
A1
Journal Article
in
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
2021
2018
Post-PEGylated and crosslinked polymeric ssRNA nanocomplexes as adjuvants targeting lymph nodes with increased cytolytic T cell inducing properties
Bo Lou
Ans De Beuckelaer
George Dakwar
Katrien Remaut
Johan Grooten
Kevin Braeckmans
Bruno De Geest
Enrico Mastrobattista
Stefaan De Koker
Wim E. Hennink
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2018
Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes
Lien Van Hoecke
Sandra Van Lint
Kenny Roose
Alexander Van Parys
Peter Vandenabeele
Johan Grooten
Jan Tavernier
Stefaan De Koker
Xavier Saelens
A1
Journal Article
in
NATURE COMMUNICATIONS
2018
2017
Arginine-rich peptide-based mRNA nanocomplexes efficiently instigate cytotoxic T cell immunity dependent on the amphipathic organization of the peptide
Vimal Kumar Udhayakumar
Ans De Beuckelaer
Joanne McCaffrey
Cian M McCrudden
Jonathan L Kirschman
Daryll Vanover
Lien Van Hoecke
Kenny Roose
Kim Deswarte
Bruno De Geest
et al.
A1
Journal Article
in
ADVANCED HEALTHCARE MATERIALS
2017
Development and validation of synthetic-virus like vaccines
Vimal Kumar Udhayakumar
Johan Grooten
Stefaan De Koker
Dissertation
2017
Inflammatory monocytes regulate Th1 oriented immunity to CpG adjuvanted protein vaccines through production of IL-12
Stefaan De Koker
Lien Van Hoecke
Ans De Beuckelaer
Kenny Roose
Kim Deswarte
Monique Willart
Pieter Bogaert
Thomas Naessens
Bruno De Geest
Xavier Saelens
et al.
A1
Journal Article
in
SCIENTIFIC REPORTS
2017
Mycolates of Mycobacterium tuberculosis modulate the flow of cholesterol for bacillary proliferation in murine macrophages
Ilke Vermeulen
Mark Baird
Juma Al-Dulayymi
Muriel Smet
Jan Verschoor
Johan Grooten
A1
Journal Article
in
JOURNAL OF LIPID RESEARCH
2017
Tuberculosis : how different synthetic analogues of pathogen associated mycolates affect lipid homeostasis of murine host macrophages
Ilke Vermeulen
Jan Verschoor
Johan Grooten
Dissertation
2017
Type I interferons modulate CD8⁺ T cell immunity to mRNA vaccines
Ans De Beuckelaer
Johan Grooten
Stefaan De Koker
A1
Journal Article
in
TRENDS IN MOLECULAR MEDICINE
2017
2016
Cholesterol-sensing liver X receptors stimulate Th2-driven allergic eosinophilic asthma in mice
Muriel Smet
Lien Van Hoecke
Ans De Beuckelaer
Seppe Vander Beken
Thomas Naessens
Karl Vergote
Monique Willart
Bart Lambrecht
Jan-Ake Gustafsson
Knut R Steffensen
et al.
A2
Journal Article
in
IMMUNITY INFLAMMATION AND DISEASE
2016
Coadministration of a plasmid encoding HIV-1 Gag enhances the efficacy of cancer DNA vaccines
Laure Lambricht
Kevin Vanvarenberg
Ans De Beuckelaer
Lien Van Hoecke
Johan Grooten
Bernard Ucakar
Pascale Lipnik
Niek Sanders
Stefan Lienenklaus
Véronique Préat
et al.
A1
Journal Article
in
MOLECULAR THERAPY
2016
Engineering polymer hydrogel nanoparticles for lymph node-targeted delivery
Stefaan De Koker
Jivei Cui
Nane Vanparijs
Lorenzo Albertazzi
Johan Grooten
Frank Caruso
Bruno De Geest
A1
Journal Article
in
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2016
GM-CSF treatment prevents respiratory syncytial virus– induced pulmonary exacerbation responses in postallergic mice by stimulating alveolar macrophage maturation
Thomas Naessens
Bert Schepens
Muriel Smet
Charlotte Pollard
Lien Van Hoecke
Ans De Beuckelaer
Monique Willart
Bart Lambrecht
Stefaan De Koker
Xavier Saelens
et al.
A1
Journal Article
in
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
2016
Mycobacterium tuberculosis-associated synthetic mycolates differentially exert immune stimulatory adjuvant activity
Muriel Smet
Charlotte Pollard
Ans De Beuckelaer
Lien Van Hoecke
Seppe Vander Beken
Stefaan De Koker
Juma'a R Al Dulayymi
Kris Huygen
Jan Verschoor
Mark S Baird
et al.
A1
Journal Article
in
EUROPEAN JOURNAL OF IMMUNOLOGY
2016
Spontaneous protein adsorption on graphene oxide nanosheets allowing efficient intracellular vaccine protein delivery
Hui Li
Kaat Fierens
Zhiyue Zhang
Nane Vanparijs
Martijn Schuijs
Katleen Van Steendam
Natalia Feiner Gracia
Riet De Rycke
Thomas De Beer
Ans De Beuckelaer
et al.
A1
Journal Article
in
ACS APPLIED MATERIALS & INTERFACES
2016
Type I interferons interfere with the capacity of mRNA lipoplex vaccines to elicit cytolytic T cell responses
Ans De Beuckelaer
Charlotte Pollard
Sandra Van Lint
Kenny Roose
Lien Van Hoecke
Tom Naessens
Vimal Kumar Udhayakumar
Muriel Smet
Niek Sanders
Stefan Lienenklaus
et al.
A1
Journal Article
in
MOLECULAR THERAPY
2016
Vaccination with necroptotic cancer cells induces efficient anti-tumor immunity
Tania Love Aaes
Agnieszka Kaczmarek
Tinneke Delvaeye
Bram De Craene
Stefaan De Koker
Liesbeth Heyndrickx
Iris Delrue
Joachim Taminau
Bartosz Wiernicki
Philippe De Groote
et al.
A1
Journal Article
in
CELL REPORTS
2016
mRNA-based vaccines to elicit CD8⁺ T cell immunity
Ans De Beuckelaer
Johan Grooten
Stefaan De Koker
Dissertation
2016
pH-Degradable mannosylated nanogels for dendritic cell targeting
Ruben De Coen
Nane Vanparijs
Martijn Risseeuw
Lien Lybaert
Benoit Louage
Stefaan De Koker
Vimal Kumar Udhayakumar
Johan Grooten
Leeanne Taylor
Neil Ayres
et al.
A1
Journal Article
in
BIOMACROMOLECULES
2016
pH-degradable imidazoquinoline-ligated nanogels for lymph node-focused immune activation
Lutz Nuhn
Nane Vanparijs
Ans De Beuckelaer
Lien Lybaert
Glenn Verstraete
Kim Deswarte
Stefan Lienenklaus
Nikunj M Shukla
Alex CD Salyer
Bart Lambrecht
et al.
A1
Journal Article
in
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2016
2015
E-cadherin expression in macrophages dampens their inflammatory responsiveness in vitro, but does not modulate M2-regulated pathologies in vivo
Jan Van den Bossche
Damya Laoui
Thomas Naessens
Hermelijn H Smits
Cornelis H Hokke
Benoit Stijlemans
Johan Grooten
Patrick De Baetselier
Jo A Van Ginderachter
A1
Journal Article
in
SCIENTIFIC REPORTS
2015
Hybrid pulmonary surfactant-coated nanogels mediate efficient in vivo delivery of siRNA to murine alveolar macrophages
Lynn De Backer
Thomas Naessens
Stefaan De Koker
Elisa Zagato
Jo Demeester
Johan Grooten
Stefaan De Smedt
Koen Raemdonck
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2015
Neutralizing TNFα restores glucocorticoid sensitivity in a mouse model of neutrophilic airway inflammation
Lien Dejager
Karen Dendoncker
Melanie Eggermont
Jolien Souffriau
Filip Van Hauwermeiren
Monique Willart
Elien Van Wonterghem
Thomas Naessens
Marlies Ballegeer
Sofie Vandevyver
et al.
A1
Journal Article
in
MUCOSAL IMMUNOLOGY
2015
The site of administration influences both the type and the magnitude of the immune response induced by DNA vaccine electroporation
Gaëlle Vandermeulen
Kevin Vanvarenberg
Ans De Beuckelaer
Stefaan De Koker
Laure Lambricht
Catherine Uyttenhove
Anca Reschner
Alain Vanderplasschen
Johan Grooten
Véronique Préat
A1
Journal Article
in
VACCINE
2015
2014
Boosting in planta production of antigens derived from the porcine reproductive and respiratory syndrome virus (PRRSV) and subsequent evaluation of their immunogenicity
Robin Piron
Stefaan De Koker
Annelies De Paepe
Julie Goossens
Johan Grooten
Hans Nauwynck
Anna Depicker
A1
Journal Article
in
PLOS ONE
2014
Cholesterol-sensing liver X receptors and mycolic acid bio-lipids at the crossroads of lipid metabolism and inflammation
Muriel Smet
Johan Grooten
Dissertation
2014
Nanoporous hydrogen bonded polymeric microparticles: facile and economic production of cross presentation promoting vaccine carriers
Marijke Dierendonck
Kaat Fierens
Riet De Rycke
Lien Lybaert
Samarendra Maji
Zhiyue Zhang
Qilu Zhang
Richard Hoogenboom
Bart Lambrecht
Johan Grooten
et al.
A1
Journal Article
in
ADVANCED FUNCTIONAL MATERIALS
2014
Nanoporous polyelectrolyte vaccine microcarriers: a formulation platform for enhancing humoral and cellular immune responses
Stefaan De Koker
Kaat Fierens
Marijke Dierendonck
Riet De Rycke
Bart Lambrecht
Johan Grooten
Jean Paul Remon
Bruno De Geest
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2014
2013
Challenges and advances towards the rational design of mRNA vaccines
Charlotte Pollard
Stefaan De Koker
Xavier Saelens
Guido Vanham
Johan Grooten
A1
Journal Article
in
TRENDS IN MOLECULAR MEDICINE
2013
Evaluation of CD8⁺ T cell responses upon mRNA vaccination and the implication of type I IFN signaling
Charlotte Pollard
Johan Grooten
Stefaan De Koker
Guido Vanham
Dissertation
2013
Lipoplexes carrying mRNA encoding Gag protein modulate dendritic cells to stimulate HIV-specific immune responses
Winni De Haes
Joanna Rejman
Charlotte Pollard
Céline Merlin
Marc Vekemans
Eric Florence
Stefaan De Smedt
Johan Grooten
Guido Vanham
Stefaan De Koker
et al.
A1
Journal Article
in
NANOMEDICINE
2013
M2e-displaying virus-like particles with associated RNA promote T helper 1 type adaptive immunity against influenza A
Lorena Ibanez
Kenny Roose
Marina De Filette
Michael Schotsaert
Jessica De Sloovere
Stefan Roels
Charlotte Pollard
Bert Schepens
Johan Grooten
Walther Fiers
et al.
A1
Journal Article
in
PLOS ONE
2013
Screening of the vascular endothelial growth factor family in human colon cancer
Sarah Pringels
Johan Grooten
Dissertation
2013
Type I IFN counteracts the induction of antigen-specific immune responses by lipid-based delivery of mRNA vaccines
Charlotte Pollard
Joanna Rejman
Winni De Haes
Bernard Verrier
Ellen Van Gulck
Thomas Naessens
Stefaan De Smedt
Pieter Bogaert
Johan Grooten
Guido Vanham
et al.
A1
Journal Article
in
MOLECULAR THERAPY
2013
2012
Clinical procedure for colon carcinoma tissue sampling directly affects the cancer marker-capacity of VEGF family members
Sarah Pringels
Nancy Van Damme
Bram De Craene
Piet Pattyn
Wim Ceelen
Marc Peeters
Johan Grooten
A1
Journal Article
in
BMC CANCER
2012
Functional dynamics of resident alveolar macrophages in a mouse model of allergic asthma
Thomas Naessens
Johan Grooten
Dissertation
2012
IL-15 augments TCR-induced CD4⁺ T cell expansion in vitro by inhibiting the suppressive function of CD25High CD4⁺ T cells
Tom Van Belle
Hans Dooms
Tom Boonefaes
Xiao-Qing Wei
Georges Leclercq
Johan Grooten
A1
Journal Article
in
PLOS ONE
2012
Innate imprinting of murine resident alveolar macrophages by allergic bronchial inflammation causes a switch from hypoinflammatory to hyperinflammatory reactivity
Thomas Naessens
Seppe Vander Beken
Pieter Bogaert
Nico Van Rooijen
Stefan Lienenklaus
Siegfried Weiss
Stefaan De Koker
Johan Grooten
A1
Journal Article
in
AMERICAN JOURNAL OF PATHOLOGY
2012
Mycobacterium tuberculosis bio-lipid mycolic acid and mammalian cholesterol-sensor liver X receptor in airway immunity
Seppe Vander Beken
Johan Grooten
Dissertation
2012
Polyelectrolyte LbL microcapsules versus PLGA microparticles for immunization with a protein antigen
Marie-Luce De Temmerman
Joanna Rejman
Roosmarijn Vandenbroucke
Stefaan De Koker
Claude Libert
Johan Grooten
Jo Demeester
Bruno Gander
Stefaan De Smedt
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2012
Polymeric multilayer capsule-mediated vaccination induces protective immunity against cancer and viral infection
Bruno De Geest
Monique Willart
Hamida Hammad
Bart Lambrecht
Charlotte Pollard
Pieter Bogaert
Marina De Filette
Xavier Saelens
Chris Vervaet
Jean Paul Remon
et al.
A1
Journal Article
in
ACS NANO
2012
Spatiotemporal autophagic degradation of oxidatively damaged organelles after photodynamic stress is amplified by mitochondrial reactive oxygen species
Noemi Rubio
Isabelle Coupienne
Emmanuel Di Valentin
Ingeborg Heirman
Johan Grooten
Jacques Piette
Patrizia Agostinis
A1
Journal Article
in
AUTOPHAGY
2012
Surface-engineered polyelectrolyte multilayer capsules: synthetic vaccines mimicking microbial structure and function
Bruno De Geest
Monique Willart
Bart Lambrecht
Charlotte Pollard
Chris Vervaet
Jean Paul Remon
Johan Grooten
Stefaan De Koker
A1
Journal Article
in
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2012
Towards understanding the functional diversity of cell wall mycolic acids of Mycobacterium tuberculosis
Jan A Verschoor
Mark S Baird
Johan Grooten
A1
Journal Article
in
PROGRESS IN LIPID RESEARCH
2012
2011
Designing polymeric particles for antigen delivery
Stefaan De Koker
Bart Lambrecht
Monique Willart
Yvette van Kooyk
Johan Grooten
Chris Vervaet
Jean Paul Remon
Bruno De Geest
A1
Journal Article
in
CHEMICAL SOCIETY REVIEWS
2011
Do-it-yourself: construction of a custom cDNA macroarray platform with high sensitivity and linear range
Tom Boonefaes
Erica Houthuys
Rafael Van den Bergh
Seppe Vander Beken
Geert Raes
Peter Brouckaert
P De Baetselier
Johan Grooten
A1
Journal Article
in
BMC BIOTECHNOLOGY
2011
Inflammatory signatures for eosinophilic vs. neutrophilic allergic pulmonary inflammation reveal critical regulatory checkpoints
Pieter Bogaert
Thomas Naessens
Stefaan De Koker
Benoit Hennuy
Jonathan Hacha
Muriel Smet
Didier Cataldo
Emmanuel Di Valentin
Jacques Piette
Kurt Tournoy
et al.
A1
Journal Article
in
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
2011
Lyophilization of protein-loaded polyelectrolyte microcapsules
Marie-Luce De Temmerman
Joanna Rejman
Johan Grooten
Thomas De Beer
Chris Vervaet
Jo Demeester
Stefaan De Smedt
A1
Journal Article
in
PHARMACEUTICAL RESEARCH
2011
Molecular structure of the Mycobacterium tuberculosis virulence factor, mycolic acid, determines the elicited inflammatory pattern
Seppe Vander Beken
Juma'a R Al Dulayymi
Thomas Naessens
Gani Koza
Max Maza-Iglesias
Richard Rowles
Cornelia Theunissen
Jelle De Medts
Ellen Lanckacker
Mark S Baird
et al.
A1
Journal Article
in
EUROPEAN JOURNAL OF IMMUNOLOGY
2011
Polymeric multilayer capsules delivering biotherapeutics
Stefaan De Koker
Liesbeth De Cock
Pilar Rivera-Gil
Wolfgang J Parak
Rachel Auzély Velty
Chris Vervaet
Jean Paul Remon
Johan Grooten
Bruno De Geest
A1
Journal Article
in
ADVANCED DRUG DELIVERY REVIEWS
2011
Single-step formation of degradable intracellular biomolecule microreactors
Marijke Dierendonck
Stefaan De Koker
Riet De Rycke
Pieter Bogaert
Johan Grooten
Chris Vervaet
Jean Paul Remon
Bruno De Geest
A1
Journal Article
in
ACS NANO
2011
2010
A single step process for the synthesis of antigen laden thermosensitive microparticles
Bruno De Geest
Stefaan De Koker
Yves Gonnissen
Liesbeth De Cock
Johan Grooten
Jean Paul Remon
Chris Vervaet
A1
Journal Article
in
SOFT MATTER
2010
Biodegradable polyelectrolyte microcapsules: antigen delivery tools with Th17 skewing activity after pulmonary delivery
Stefaan De Koker
Thomas Naessens
Bruno De Geest
Pieter Bogaert
Jo Demeester
Stefaan De Smedt
Johan Grooten
A1
Journal Article
in
JOURNAL OF IMMUNOLOGY
2010
Facile two-step synthesis of porous antigen-loaded degradable polyelectrolyte microspheres
Marijke Dierendonck
Stefaan De Koker
Claude Cuvelier
Johan Grooten
Chris Vervaet
Jean Paul Remon
Bruno De Geest
A1
Journal Article
in
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2010
PH1-derived bivalent bibodies and trivalent tribodies bind differentially to shed and tumour cell-associated MUC1
Steve Schoonooghe
Ingrid Burvenich
Liesbet Vervoort
Filip De Vos
Nico Mertens
Johan Grooten
A1
Journal Article
in
PROTEIN ENGINEERING DESIGN & SELECTION
2010
Polyelectrolyte capsules-containing HIV-1 p24 and poly I:C modulate dendritic cells to stimulate HIV-1-specific immune responses
Winni De Haes
Stefaan De Koker
Charlotte Pollard
Derek Atkinson
Erika Vlieghe
Jessy Hoste
Joanna Rejman
Stefaan De Smedt
Johan Grooten
Guido Vanham
et al.
A1
Journal Article
in
MOLECULAR THERAPY
2010
Polymeric multilayer capsules in drug delivery
Liesbeth De Cock
Stefaan De Koker
Bruno De Geest
Johan Grooten
Chris Vervaet
Jean Paul Remon
Gleb B Sukhorukov
Maria N Antipina
A1
Journal Article
in
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2010
Structure-function relationships of the antigenicity of mycolic acids in tuberculosis patients
Mervyn Beukes
Yolandy Lemmer
Madrey Deysel
R Al Dulayymi Juma'a
S Baird Mark
Gani Koza
M Iglesias Maximiliano
R Rowles Richard
Cornelia Theunissen
Johan Grooten
et al.
A1
Journal Article
in
CHEMISTRY AND PHYSICS OF LIPIDS
2010
Transcriptome analysis of monocyte-HIV interactions
Rafael Van den Bergh
Eric Florence
Erika Vlieghe
Tom Boonefaes
Johan Grooten
Erica Houthuys
Huyen Thi Thanh Tran
Youssef Gali
Patrick De Baetselier
Guido Vanham
et al.
A1
Journal Article
in
RETROVIROLOGY
2010
2009
Alternatively activated macrophages engage in homotypic and heterotypic interactions through IL-4 and polyamine-induced E-cadherin/catenin complexes
J Van den Bossche
Pieter Bogaert
Jolanda van Hengel
Chris Guerin
Geert Berx
K Movahedi
R Van den Bergh
A Pereira-Fernandes
JMC Geuns
H Pircher
et al.
A1
Journal Article
in
BLOOD
2009
Efficient production of human bivalent and trivalent anti-MUC1 Fab-scFv antibodies in Pichia pastoris
Steve Schoonooghe
Vladimir Kaigorodov
Monika Zawisza
Caroline Dumolyn
Jurgen Haustraete
Johan Grooten
Nico Mertens
A1
Journal Article
in
BMC BIOTECHNOLOGY
2009
Liver X receptors contribute to the protective immune response against Mycobacterium tuberculosis in mice
Hannelie Korf
Seppe Vander Beken
Marta Romano
Knut Steffensen
Benoit Stijlemans
Jan-Ake Gustafsson
Johan Grooten
Kris Huygen
A1
Journal Article
in
JOURNAL OF CLINICAL INVESTIGATION
2009
New asthma biomarkers: lessons from murine models of acute and chronic asthma
Emmanuel Di Valentin
Celine Crahay
Nancy Garbacki
Benoit Hennuy
Maud Gueders
Agnes Noel
Jean-Michel Foidart
Johan Grooten
Alain Colige
Jacques Piette
et al.
A1
Journal Article
in
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
2009
Polyelectrolyte Microcapsules as Antigen Delivery Vehicles To Dendritic Cells: Uptake, Processing, and Cross-Presentation of Encapsulated Antigens
Stefaan De Koker
Bruno De Geest
Satwinder Singh
Riet De Rycke
Thomas Naessens
Yvette Van Kooyk
Jo Demeester
Stefaan De Smedt
Johan Grooten
A1
Journal Article
in
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2009
The first unique synthetic mycobacterial cord factors
JR Al Dulayymi
MS Baird
M Maza-Iglesias
Seppe Vander Beken
Johan Grooten
A1
Journal Article
in
TETRAHEDRON LETTERS
2009
Where asthma and hypersensitivity pneumonitis meet and differ: noneosinophilic severe asthma
Pieter Bogaert
Kurt Tournoy
Thomas Naessens
Johan Grooten
A1
Journal Article
in
American Journal of Pathology
2009
2008
Cholesteroid nature of free mycolic acids from M. tuberculosis
Yolandy Benadie
Madrey Deysel
D. Gilbert R. Siko
Vanessa V. Roberts
Sandra Van Wyngaardt
Simon T. Thanyani
Gianna Sekanka
Annemieke M.C. Ten Bokum
Lynne A. Collett
Johan Grooten
et al.
A1
Journal Article
in
CHEMISTRY AND PHYSICS OF LIPIDS
2008
2007
Mycolic acids for the control of tuberculosis
G SEKANKA
M BAIRD
D MINNIKIN
Johan Grooten
A1
Journal Article
in
EXPERT OPINION ON THERAPEUTIC PATENTS
2007
2006
Animal models of allergen-induced tolerance in asthma: are T-regulatory-1 cells (Tr-1) the solution for T-helper-2 cells (Th-2) in asthma?
Kurt Tournoy
Chris Van Hove
Johan Grooten
K MOERLOOSE
Guy Brusselle
Guy Joos
A1
Journal Article
in
CLINICAL AND EXPERIMENTAL ALLERGY
2006
Blocking tumor cell eicosanoid synthesis by GPx4 impedes tumor growth and malignancy
Ingeborg Heirman
Daisy Ginneberge
B BRIGELIUS-FLOHE
N HENDRICKX
P AGOSTINIS
Peter Brouckaert
Pieter Rottiers
Johan Grooten
A1
Journal Article
in
FREE RADICAL BIOLOGY AND MEDICINE
2006
IL-15 augments CD4+T-cell proliferation by inhibiting the suppressive function of CD25HighCD4+regulatory T-cells
Tom Van Belle
Tom Boonefaes
Georges Leclercq
Johan Grooten
C3
Conference
2006
Macrophage reprogramming by mycolic acid promotes a tolerogenic response in experimental asthma
Johanna Korf
Gwenda Pynaert
Kurt Tournoy
Tom Boonefaes
A VAN OOSTERHOUT
Daisy Ginneberge
Anuschka Haegeman
JA VERSCHOOR
P DE BAETSELIER
Johan Grooten
A1
Journal Article
in
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
2006
Role of endoplasmic reticulum depletion and multidomain proapoptotic BAX and BAK proteins in shaping cell death after hypericin-mediated photodynamic therapy
E BUYTAERT
G CALLEWAERT
N HENDRICKX
L SCORRANO
D HARTMANN
L MISSIAEN
JR VANDENHEEDE
Ingeborg Heirman
Johan Grooten
P AGOSTINIS
A1
Journal Article
in
FASEB JOURNAL
2006
2005
CD3 x CD28 cross-interacting bispecific antibodies improve tumor cell dependent T-cell activation
An Willems
Steve Schoonooghe
Dominique Eeckhout
Geert De Jaeger
Johan Grooten
Nico Mertens
A1
Journal Article
in
CANCER IMMUNOLOGY IMMUNOTHERAPY
2005
Enhancement of polymethacrylate-mediated gene delivery by Penetratin
Bart Christiaens
Peter Dubruel
Johan Grooten
Marc Goethals
Joël Vandekerckhove
Etienne Schacht
Marie Rosseneu
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
2005
IL-15 and IL-15R alpha in CD4(+) T cell immunity
Tom Van Belle
Johan Grooten
A1
Journal Article
in
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
2005
Lipo-protein I, a TLR2/4 ligand modulates Th2-driven allergic immune responses
H REVETS
Gwenda Pynaert
Johan Grooten
P DE BAETSELIER
A1
Journal Article
in
JOURNAL OF IMMUNOLOGY
2005
Lysophosphatidic acid affinity chromatography reveals pyruvate kinase as a specific LPA-binding protein
S DESMARET
L QIAN
Berlinda Vanloo
Kris Meerschaert.kr
Jozef Van Damme
Johan Grooten
Joël Vandekerckhove
GD PRESTWICH
Jan Gettemans
A1
Journal Article
in
BIOLOGICAL CHEMISTRY
2005
Macrophage galactose-type C-type lectins as novel markers for alternatively activated macrophages elicited by parasitic infections and allergic airway inflammation
G RAES
L BRYS
BK DAHAL
J BRANDT
Johan Grooten
F BROMBACHER
G VANHAM
W NOEL
Pieter Bogaert
Tom Boonefaes
et al.
A1
Journal Article
in
JOURNAL OF LEUKOCYTE BIOLOGY
2005
The Mycobacterium tuberculosis cell wall component mycolic acid elicits pathogen-associated host innate immune responses
Johanna Korf
A STOLTZ
J VERSCHOOR
P DE BAETSELIER
Johan Grooten
A1
Journal Article
in
EUROPEAN JOURNAL OF IMMUNOLOGY
2005
Tumor cell eicosanoids promote tumor growth, metastasis and escape from angiodestructive tumor therapy
I HEIRMAN
Daisy Ginneberge
R BRIGELIUS-FLOHE
N HENDRICKX
P AGOSTINIS
P ROTTIERS
Johan Grooten
C3
Conference
2005
2004
Buffering properties of cationic polymethacrylates are not the only key to successful gene delivery
Peter Dubruel
Bart Christiaens
Maryvonne Rosseneu
Joël Vandekerckhove
Johan Grooten
Vera Goossens
Etienne Schacht
A1
Journal Article
in
BIOMACROMOLECULES
2004
Cytoglobin expression is upregulated in all tissues upon hypoxia: an in vitro and in vivo study by quantitative real-time PCR
E Fordel
E Geuens
Sylvia Dewilde
Pieter Rottiers
P Carmeliet
Johan Grooten
Luc Moens
A1
Journal Article
in
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2004
Enhancement of polymethacrylate-mediated gene delivery by penetratin
Peter Dubruel
Bart Christiaens
Johan Grooten
Marc Goethals
Joël Vandekerckhove
Etienne Schacht
Marie Rosseneu
C3
Conference
2004
Membrane interaction and cellular internalization of penetratin peptides
Bart Christiaens
Johan Grooten
M REUSENS
A JOLIOT
Marc Goethals
Joël Vandekerckhove
A PROCHIANTZ
Maryvonne Rosseneu
A1
Journal Article
in
EUROPEAN JOURNAL OF BIOCHEMISTRY
2004
New strategies in polypeptide and antibody synthesis: An overview
Nico Mertens
F DEVOS
Jannick Leoen
Els Van Deynse
An Willems
Steve Schoonooghe
Ingrid Burvenich
Stefaan De Koker
Dominique Vlieghe
Johan Grooten
et al.
A1
Journal Article
in
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
2004
Phosphorylation by protein kinase CK2 modulates the activity of the ATP binding cassette A1 transporter
Stein Roosbeek
Frank Peelman
Annick Verhee
Christine Labeur
H CASTER
Marc Lensink
C CIRULLI
Johan Grooten
C COCHET
Joël Vandekerckhove
et al.
A1
Journal Article
in
JOURNAL OF BIOLOGICAL CHEMISTRY
2004
Response of TNF-hyporesponsive SPRET/Ei mice in models of inflammatory disorders
Jan Staelens
Leen Puimège
Tina Mahieu
Gwenda Pynaert
Tino Hochepied
Annelies Vandenabeele
Johan Grooten
Dimitris Kontoyiannis
Frans Van Roy
George Kollias
et al.
A1
Journal Article
in
MAMMALIAN GENOME
2004
2003
Airway IgG counteracts specific and bystander allergen-triggered pulmonary inflammation by a mechanism dependent on Fc gamma R and IFN-gamma
S SEHRA
Gwenda Pynaert
Kurt Tournoy
Anuschka Haegeman
P MATTHYS
Y TAGAWA
Romain Pauwels
Johan Grooten
A1
Journal Article
in
JOURNAL OF IMMUNOLOGY
2003
Antigen presentation by local macrophages promotes nonallergic airway responses in sensitized mice
Gwenda Pynaert
Pieter Rottiers
Anuschka Haegeman
Sarita Sehra
Tom Van Belle
Johanna Korf
Johan Grooten
A1
Journal Article
in
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
2003
Eicosanoid mediators in health, inflammation and cancer.
Ingeborg Heirman
Johan Grooten
Bookchapter
in
Recent Research Developments in Cell Biology
2003
Optimizing expression and purification from cell culture medium of trispecific recombinant antibody derivatives
An Willems
Jannick Leoen
Steve Schoonooghe
Johan Grooten
Nico Mertens
A1
Journal Article
in
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
2003
2002
Induction of IL-15 by TCR/CD3 aggregation depends on IFN-gamma and protects against apoptosis of immature thymocytes in vivo.
P MATTHYS
Hans Dooms
Pieter Rottiers
T MITERA
L OVERBERGH
Georges Leclercq
A BILLIAU
Johan Grooten
A1
Journal Article
in
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
2002
Regulation of T-cell life and death in the periphery.
Hans Dooms
Tom Van Belle
Johan Grooten
Bookchapter
in
Recent Research Developments in Immunology, Research Signpost, 2002. - ISBN 81-7736-142-2
2002
Tumor necrosis factor-induced modulation of glyoxalase I activities through phosphorylation by PKA results in cell death and is accompanied by the formation of a specific methyl glyoxal-derived AGE.
Franky Van Herreweghe
JQ MAO
F CHAPLEN
Johan Grooten
Kris Gevaert
Joël Vandekerckhove
Katia Vancompernolle
A1
Journal Article
in
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2002
2001
A new model for intermediate molecular weight recombinant bispecific and trispecific antibodies by efficient heterodimerization of single chain variable domains through fusion to a Fab-chain.
Reinhilde Schoonjans
An Willems
Steve Schoonooghe
J LEOEN
Johan Grooten
Nico Mertens
A1
Journal Article
in
BIOMOLECULAR ENGINEERING
2001
Death receptor-induced apoptotic and necrotic cell death: differential role of caspases and mitochondria.
Geertrui Denecker
D VERCAMMEN
Margino Steemans
Tom Vanden Berghe
Greet Brouckaert
Geert van Loo
B ZHIVOTOVSKY
Walther Fiers
Johan Grooten
Wim Declercq
et al.
A1
Journal Article
in
CELL DEATH AND DIFFERENTIATION
2001
New recombinant bi- and trispecific antibody derivatives
Nico Mertens
Reinhilde Schoonjans
An Willems
Steve Schoonooghe
Jannick Leoen
Johan Grooten
P1
Conference
2001
2000
Efficient heterodimerization of recombinant bi- and trispecific antibodies.
Reinhilde Schoonjans
An Willems
Johan Grooten
Nico Mertens
A1
Journal Article
in
BIOSEPARATION
2000
Fab chains as an efficient heterodimerization scaffold for the production of recombinant bispecific and trispecific antibody derivatives.
Reinhilde Schoonjans
An Willems
Steve Schoonooghe
Walther Fiers
Johan Grooten
Nico Mertens
A1
Journal Article
in
JOURNAL OF IMMUNOLOGY
2000
Interleukin-15 redirects the outcome of a tolerizing T-cell stimulus from apoptosis to anergy.
Hans Dooms
Tom Van Belle
Marjory Desmedt
Pieter Rottiers
Johan Grooten
A1
Journal Article
in
BLOOD
2000
Macrophages present pinocytosed exogenous antigen via MHC class I whereas antigen ingested by receptor-mediated endocytosis is presented via MHC class II.
MP PEPPELENBOSCH
Marjory Desmedt
Gwenda Pynaert
SJH VAN DEVENTER
Johan Grooten
A1
Journal Article
in
JOURNAL OF IMMUNOLOGY
2000
Phosphatidyl serine exposure during apoptosis precedes release of cytochrome c and decrease in mitochondrial transmembrane potential.
Geertrui Denecker
Hans Dooms
Geert van Loo
D VERCAMMEN
Johan Grooten
Walther Fiers
Wim Declercq
Peter Vandenabeele
A1
Journal Article
in
FEBS LETTERS
2000
Role of reactive oxygen species in tumor necrosis factor toxicity
Vera Goossens
Kurt De Vos
Dominique Vercammen
Margino Steemans
Katia Vancompernolle
Walther Fiers
Peter Vandenabeele
Johan Grooten
Bookchapter
in
Antioxidant and redox regulation of genes
2000
Tumor necrosis factor induces hyperphosphorylation of kinesin light chain and inhibits kinesin-mediated transport of mitochondria.
Kurt De Vos
F SEVERIN
F VAN HERREWEGHE
K VANCOMPERNOLLE
Vera Goossens
A HYMAN
Johan Grooten
A1
Journal Article
in
JOURNAL OF CELL BIOLOGY
2000
Tumor necrosis factor-induced microtubule stabilization mediated by hyperphosphorylated oncoprotein 18 promotes cell death.
K VANCOMPERNOLLE
Tom Boonefaes
M MANN
Walther Fiers
Johan Grooten
A1
Journal Article
in
JOURNAL OF BIOLOGICAL CHEMISTRY
2000
1999
Cysteinyl leukotrienes mediate histamine hypersensitivity ex vivo by increasing histamine receptor numbers.
Gwenda Pynaert
Johan Grooten
SJH VAN DEVENTER
MP PEPPELENBOSCH
A1
Journal Article
in
MOLECULAR MEDICINE
1999
Lipopolysaccharide regulates macrophage fluid phase pinocytosis via CD14-dependent and CD14-independent pathways.
MP PEPPELENBOSCH
Marjory Desmedt
T TEN HOVE
SJH VAN DEVENTER
Johan Grooten
A1
Journal Article
in
BLOOD
1999
Multiple signal transduction pathways regulate TNF-induced actin reorganization in macrophages: Inhibition of Cdc42-mediated filopodium formation by TNF.
M PEPPELENBOSCH
Elke Boone
GE JONES
SJH VAN DEVENTER
Guy Haegeman
Walther Fiers
Johan Grooten
AJ RIDLEY
A1
Journal Article
in
JOURNAL OF IMMUNOLOGY
1999
Redox regulation of TNF signaling.
Vera Goossens
Kurt De Vos
D VERCAMMEN
Margino Steemans
K VANCOMPERNOLLE
Walther Fiers
Peter Vandenabeele
Johan Grooten
A1
Journal Article
in
BIOFACTORS
1999
Regulation of tumor necrosis factor-induced, mitochondria- and reactive oxygen species-dependent cell death by the electron flux through the electron transport chain complex I
Vera Goossens
Geert Stangé
KATHLEEN MOENS
Daniel Pipeleers
Johan Grooten
A2
Journal Article
in
Antioxidants & Redox Signaling
1999
Tumoral environment triggers transcript anomalies in established tumors : induction of altered gene expression and of aberrant, truncated and B2 repeat-containing gene transcripts
Pieter Rottiers
Marjory Desmedt
Hans Dooms
Roland Contreras
Johan Grooten
A2
Journal Article
in
NEOPLASIA
1999
1998
A caspase-activated factor (CAF) induces mitochondrial membrane depolarization and cytochrome c release by a nonproteolytic mechanism.
Margino Steemans
Vera Goossens
Marc Van De Craen
F VAN HERREWEGHE
Katia Vancompernolle
Kurt De Vos
Peter Vandenabeele
Johan Grooten
A1
Journal Article
in
JOURNAL OF EXPERIMENTAL MEDICINE
1998
Atractyloside-induced release of cathepsin B, a protease with caspase-processing activity.
Katia Vancompernolle
F VAN HERREWEGHE
Gwenda Pynaert
Marc Van De Craen
Kurt De Vos
N TOTTY
A STERLING
Walther Fiers
Peter Vandenabeele
Johan Grooten
A1
Journal Article
in
FEBS LETTERS
1998
Cathepsin B-mediated activation of the proinflammatory caspase-11
Peter Schotte
Wim Van Criekinge
Marc Van De Craen
Geert van Loo
Marjory Desmedt
Johan Grooten
Maria Cornelissen
Leo De Ridder
Joël Vandekerckhove
Walther Fiers
et al.
A1
Journal Article
in
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
1998
Differentiation of EL4 lymphoma cells by tumoral environment is associated with inappropriate expression of the large chondroitin sulfate proteoglycan PG-M and the tumor-associated antigen HTgp-175.
Pieter Rottiers
T VERFAILLIE
Roland Contreras
H REVETS
Marjory Desmedt
H DOOMS
Walther Fiers
Johan Grooten
A1
Journal Article
in
INTERNATIONAL JOURNAL OF CANCER
1998
Induction of unresponsiveness to tumor necrosis factor (TNF) after autocrine TNF expression requires TNF membrane retention.
Els Decoster
B VANHAESEBROECK
Elke Boone
S PLAISANCE
Kurt De Vos
Guy Haegeman
Johan Grooten
Walther Fiers
A1
Journal Article
in
JOURNAL OF BIOLOGICAL CHEMISTRY
1998
Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor.
Dominique Vercammen
Rudi Beyaert
Geertrui Denecker
Vera Goossens
Geert van Loo
Wim Declercq
Johan Grooten
Walther Fiers
Peter Vandenabeele
A1
Journal Article
in
JOURNAL OF EXPERIMENTAL MEDICINE
1998
Macrophages induce cellular immunity by activating Th1 cell responses and suppressing Th2 cell responses.
Marjory Desmedt
P ROTTIERS
H DOOMS
Walther Fiers
Johan Grooten
A1
Journal Article
in
JOURNAL OF IMMUNOLOGY
1998
Quiescence-inducing and antiapoptotic activities of IL-15 enhance secondary CD4(+) T cell responsiveness to antigen.
B DOOMS
Marjory Desmedt
S VANCAENEGHEM
Pieter Rottiers
Vera Goossens
Walther Fiers
Johan Grooten
A1
Journal Article
in
JOURNAL OF IMMUNOLOGY
1998
The 55-kDa tumor necrosis factor receptor induces clustering of mitochondria through its membrane-proximal region.
Kurt De Vos
Vera Goossens
Elke Boone
Dominique Vercammen
K VANCOMPERNOLLE
Peter Vandenabeele
Guy Haegeman
Walther Fiers
Johan Grooten
A1
Journal Article
in
JOURNAL OF BIOLOGICAL CHEMISTRY
1998
pH-dependent aggregation and secretion of soluble monomeric influenza hemagglutinin.
Peter Vanlandschoot
Els Beirnaert
Johan Grooten
Willy Min Jou
Walther Fiers
A1
Journal Article
in
ARCHIVES OF VIROLOGY
1998
1997
Differential role of calcium in tumour necrosis factor-mediated apoptosis and secretion of granulocyte-macrophage colony-stimulating factor in a T cell hybridoma.
Geertrui Denecker
Peter Vandenabeele
Johan Grooten
LC PENNING
Wim Declercq
Rudi Beyaert
WA BUURMAN
Walther Fiers
A1
Journal Article
in
CYTOKINE
1997
Tumour necrosis factor: intracellular mechanism of action
Walther Fiers
Rudi Beyaert
Elke Boone
Wim Declercq
Els Decoster
Dirk De Valck
Vera Goossens
Johan Grooten
Guy Haegeman
Karen Heyninck
et al.
Bookchapter
in
HIV and cytokines
1997
1996
TNF-induced intracellular signaling leading to gene induction or to cytotoxicity by necrosis or by apoptosis.
Walther Fiers
Rudi Beyaert
Elke Boone
Sigrid Cornelis
Wim Declercq
Els Decoster
Geertrui Denecker
Bart Depuydt
Dirk De Valck
G DEWILDE
et al.
A1
Journal Article
in
JOURNAL OF INFLAMMATION
1996
The oxidative metabolism of glutamine - A modulator of reactive oxygen intermediate-mediated cytotoxicity of tumor necrosis factor in L929 fibrosarcoma cells.
Vera Goossens
Johan Grooten
Walther Fiers
A1
Journal Article
in
JOURNAL OF BIOLOGICAL CHEMISTRY
1996
1995
BOTH TNF RECEPTORS ARE REQUIRED FOR TNF-MEDIATED INDUCTION OF APOPTOSIS IN PC60 CELLS.
Peter Vandenabeele
Wim Declercq
Bart Vanhaesebroeck
Johan Grooten
Walther Fiers
A1
Journal Article
in
JOURNAL OF IMMUNOLOGY
1995
Both TNF receptors are required for TNF-mediated induction of apoptosis in PC60 cells
Peter Vandenabeele
Wim Declercq
Bart Vanhaesebroeck
Johan Grooten
Walther Fiers
A2
Journal Article
in
J. Immunol.. 154, pp. 2904-2913
1995
Cytotoxicity in L929 murine fibrosarcoma cells after triggering of transfected human p75 tumour-necrosis-factor (TNF) receptor is mediated by endogenous murine TNF.
D VERCAMMEN
Peter Vandenabeele
Wim Declercq
M VANDECRAEN
Johan Grooten
Walther Fiers
A1
Journal Article
in
CYTOKINE
1995
Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity.
V GOOSSENS
Johan Grooten
K DEVOS
Walther Fiers
A1
Journal Article
in
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
1995
Generation and biological characterization of membrane-bound, uncleavable murine tumor-necrosis factor.
Els Decoster
Bart Vanhaesebroeck
Peter Vandenabeele
Johan Grooten
Walther Fiers
A1
Journal Article
in
JOURNAL OF BIOLOGICAL CHEMISTRY
1995
Involvement of IFN-γ in Bacillus Calmette-Guérin-induced but not in tumor-induced sensitization to TNF-induced lethality
Anje Cauwels
Peter Brouckaert
Johan Grooten
Sui Huang
Michel Aguet
Walther Fiers
A1
Journal Article
in
JOURNAL OF IMMUNOLOGY
1995
1994
FUNCTIONAL REQUIREMENT OF THE 2 TNF RECEPTORS FOR INDUCTION OF APOPTOSIS IN PC60 CELLS AND THE ROLE OF MITOCHONDRIA IN TNF-INDUCED CYTOTOXICITY.
Peter Vandenabeele
V GOOSSENS
Rudi Beyaert
Wim Declercq
Johan Grooten
B VANHAESEBROECK
M VANDECRAEN
D VERCAMMEN
B DEPUYDT
G DENECKER
et al.
A1
Journal Article
in
CIRCULATORY SHOCK
1994
1993
CELL-MEMBRANE PERMEABILIZATION AND CELLULAR COLLAPSE, FOLLOWED BY LOSS OF DEHYDROGENASE-ACTIVITY - EARLY EVENTS IN TUMOR NECROSIS FACTOR-INDUCED CYTOTOXICITY.
Johan Grooten
V GOOSSENS
Bart Vanhaesebroeck
Walther Fiers
A1
Journal Article
in
CYTOKINE
1993
Effect of bcl-2-proto-oncogene expression on cellular sensitivity to tumor necrosis factor-mediated cytotoxicity.
Bart Vanhaesebroeck
JC REED
D DEVALCK
Johan Grooten
T MIYASHITA
S TANAKA
Rudi Beyaert
Frans Van Roy
Walther Fiers
A1
Journal Article
in
ONCOGENE
1993
INCREASED IL-6 PRODUCTION AND IL-6-MEDIATED IG SECRETION IN MURINE HOST-VS-GRAFT DISEASE.
Peter Vandenabeele
D ABRAMOWICZ
D BERUS
J VANDERHEYDEN
Johan Grooten
V DONCKIER
EL HOOGHEPETERS
M GOLDMAN
Walther Fiers
A1
Journal Article
in
JOURNAL OF IMMUNOLOGY
1993
Two pathways of tumor necrosis factor signal transduction: in vitro and in vivo implications
Walther Fiers
Rudi Beyaert
Peter Brouckaert
Anje Cauwels
Wim Declercq
Dirk De Valck
B Everaerdt
Vera Goossens
Johan Grooten
Guy Haegeman
et al.
C1
Conference
1993
1992
Functional characterization of the human tumor necrosis factor receptor p75 in a transfected rat/mouse T cell hybridoma
Peter Vandenabeele
Wim Declercq
Dominique Vercammen
Marc Van De Craen
Johan Grooten
Hansruedi Loetscher
Manfred Brockhaus
Werner Lesslauer
Walther Fiers
A1
Journal Article
in
JOURNAL OF EXPERIMENTAL MEDICINE
1992
Tumor necrosis factor : mechanism of action and its potential for anticancer therapy
W Hers
Rudi Beyaert
Peter Brouckaert
Els Decoster
Dirk De Valck
B Everaerdt
Johan Grooten
Anne Lenaerts
Claude Libert
K Schulze-Osthoff
et al.
C1
Conference
1992
Tumor-necrosis-factor : mechanism of action at the molecular, cellular and in vivo level
Walther Fiers
Rudi Beyaert
Peter Brouckaert
Els Decoster
Dirk De Valck
Bart Everaerdt
Johan Grooten
Anne Lenaerts
Claude Libert
K. Schulzeosthoff
et al.
P1
Conference
1992
1991
Expression of the tumor necrosis factor gene in tumor cells correlates with reduced tumorigenicity and reduced invasiveness in vivo
Bart Vanhaesebroeck
Marcus Mareel
Frans Van Roy
Johan Grooten
Walther Fiers
A1
Journal Article
in
CANCER RESEARCH
1991
1990
IL-4 acts synergistically on the IL-2 response of an autoreactive T-cell clone ; synergism correlates with increased intracellular IL-2, but not with a modified IL-2 receptor expression
Peter Vandenabeele
Johan Grooten
Walther Fiers
A1
Journal Article
in
CELLULAR IMMUNOLOGY
1990
Tumor-necrosis-factor : mechanism of action at the molecular, cellular and in vivo level
Walther Fiers
Rudi Beyaert
Peter Brouckaert
Bart Everaerdt
Johan Grooten
Anne Lenaerts
Claude Libert
P. Suffys
Nozomi Takahashi
Jan Tavernier
et al.
A1
Journal Article
in
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
1990
1989
Acquisition by the murine host of responsiveness toward various neoplastic cell lines, but not toward self, through adoptive transfer of a helper T-lymphocyte clone with antiself specificity
Johan Grooten
Walther Fiers
A1
Journal Article
in
CANCER RESEARCH
1989
An ongoing in vivo immune response affects the abundancy and differentiation of lymphokine-activated killer cell precursors, but does not influence their broad spectrum target reactivity
Bart Vanhaesebroeck
Johan Grooten
Walther Fiers
A1
Journal Article
in
JOURNAL OF IMMUNOLOGY
1989
1987
Alloinduced suppression and cytotoxicity: two functions of a single cell
Geert Leroux-Roels
Johan Grooten
Walther Fiers
A1
Journal Article
in
IMMUNOLOGY LETTERS
1987
Specific suppression elicited by EL4 lymphoma cells in syngeneic mice : specificity includes self-antigens on EL4
Johan Grooten
Geert Leroux-Roels
Walther Fiers
A1
Journal Article
in
EUROPEAN JOURNAL OF IMMUNOLOGY
1987