Research Explorer

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Researcher

Jody Haigh

Awards & Distinctions

68 Results

2017

Elevated ΔNp63α levels facilitate epidermal and biliary oncogenic transformation

Michael DevosBarbara GilbertGeertrui DeneckerKirsten LeursConor Mc GuireKelly LemeireTino HochepiedMarnik VuylstekeJo LambertCaroline Van den Broecke et al.

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10

Hamida HammadMatthias VanderkerkenPhilippe PouliotKim DeswarteWendy ToussaintKarl VergoteLana VandersarrenSophie JanssensIoanna RamouSavvas Savvides et al.

A1 Journal Article in NATURE IMMUNOLOGY

Zeb2 regulates cell fate at the exit from epiblast state in mouse embryonic stem cells

Agata StryjewskaRuben DriesTim PietersGriet VerstappenAndrea ConidiKathleen CoddensAnnick FrancisLieve UmansWilfred FJ van IJckenGeert Berx et al.

A1 Journal Article in STEM CELLS

2016

The transcription factor Zeb2 regulates development of conventional and plasmacytoid DCs by repressing Id2

Charlotte ScottBieke SoenLiesbet MartensNicolas SkrypekWouter SaelensJoachim TaminauGillian BlanckeGert Van IsterdaelDanny HuylebroeckJody Haigh et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

p120 Catenin-mediated stabilization of E-cadherin is essential for primitive endoderm specification

Tim PietersSteven GoossensLieven HaenebalckeVanessa AndriesAgata StryjewskaRiet De RyckeKelly LemeireTino HochepiedDanny HuylebroeckGeert Berx et al.

A1 Journal Article in PLOS GENETICS

2015

An ER-directed gelsolin nanobody targets the first step in amyloid formation in a gelsolin amyloidosis mouse model

Wouter Van OverbekeJantana WongsantichonInge EveraertAdriaan VerhelleOlivier ZwaenepoelAnantasak LoonchantaLeslie D BurtnickAriane De GanckTino HochepiedJody Haigh et al.

A1 Journal Article in HUMAN MOLECULAR GENETICS

Immunohistological description of nongestational ovarian choriocarcinoma in two female mice with conditional loss of Trp53 driven by the Tie2 promoter

V CastiglioniMorvarid Farhang GhahremaniSteven GoossensM De MaglieM ArdizzoneJody HaighE Radaelli

A1 Journal Article in VETERINARY PATHOLOGY

Müller glia are a major cellular source of survival signals for retinal neurons in diabetes

Shuhua FuShuqian DongMeili ZhuDavid M SherryChangyun WangZhipeng YouJody HaighYu-Zheng Le

A1 Journal Article in DIABETES

Snai1 regulates cell lineage allocation and stem cell maintenance in the mouse intestinal epithelium

Katja HorvayThierry JardéFranca CasagrandaVictoria M PerreauKatharina HaighChristian M NefzgerReyhan AkhtarThomas GridleyGeert BerxJody Haigh et al.

A1 Journal Article in EMBO JOURNAL

Strategies to rescue the consequences of inducible arginase-1 deficiency in mice

Laurel L BallantyneYuan Yan SinTim St AmandJoshua SiSteven GoossensLieven HaenebalckeJody HaighLianna KyriakopoulouAndrea SchulzeColin D Funk

A1 Journal Article in PLOS ONE

Terminal NK cell maturation is controlled by concerted actions of T-bet and Zeb2 and is essential for melanoma rejection

Mary van HeldenSteven GoossensCécile DaussyAnne-Laure MathieuFabrice FaureAntoine MarçaisNiels VandammeNatalie FarlaKatia MayolSébastien Viel et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling

Steven GoossensEnrico RadaelliOdile BlanchetKaat DurinckJoni Van der MeulenSofie PeirsTom TaghonCedric S TremblayMagdaline CostaMorvarid Farhang Ghahremani et al.

A1 Journal Article in NATURE COMMUNICATIONS

2014

Identification of a ZEB2-MITF-ZEB1 transcriptional network that controls melanogenesis and melanoma progression

Geertrui DeneckerNiels VandammeOzden AkayD KoludrovicJoachim TaminauKelly LemeireAlexander GheldofBram De CraeneMireille Van GeleLieve Brochez et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Loss of autocrine endothelial-derived VEGF significantly reduces hemangiosarcoma development in conditional p53-deficient mice

Morvarid Farhang GhahremaniEnrico RadaelliKatharina HaighSona BartunkovaLieven HaenebalckeJean-Christophe MarineSteven GoossensJody Haigh

A1 Journal Article in CELL CYCLE

ZEB2-transgene expression in the epidermis compromises the integrity of the epidermal barrier through the repression of different tight junction proteins

Marianthi TatariBram De CraeneBieke SoenJoachim TaminauPetra VermassenSteven GoossensKatharina HaighSilvia CazzolaJo LambertDanny Huylebroeck et al.

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

2013

Beta-actin is involved in modulating erythropoiesis during development by fine-tuning Gata2 expression levels

Davina TondeleirBenjamin DrogatKarolina SlowickaKarima BakkaliSona BartunkovaSteven GoossensJody HaighChristophe Ampe

A1 Journal Article in PLOS ONE

Cre/loxP-transgenics

Lieven HaenebalckeJody Haigh

Bookchapter in Brenner’s encyclopedia of genetics, vol. 2

Directed migration of cortical interneurons depends on the cell-autonomous action of Sip1

Veronique van den BergheElke StappersBram VandesandeJordane DimidschsteinRoel KroesAnnick FrancisAndrea ConidiFlore LesageRuben DriesSilvia Cazzola et al.

A1 Journal Article in NEURON

Efficient ROSA26-based conditional and/or inducible transgenesis using RMCE-compatible F1 hybrid mouse embryonic stem cells

Lieven HaenebalckeSteven GoossensMichaël NaessensNatascha KruseMorvarid Farhang GhahremaniSona BartunkovaKatharina HaighTim PietersPieterjan DierickxBenjamin Drogat et al.

A1 Journal Article in STEM CELL REVIEWS AND REPORTS

Endothelial VEGF sculpts cortical cytoarchitecture

Suyan LiKatharina HaighJody HaighAnju Vasudevan

A1 Journal Article in JOURNAL OF NEUROSCIENCE

GATA3 antagonizes cancer progression in PTEN-deficient prostates

Alana HT NguyenMathieu TremblayKatharina HaighIsmaël Hervé KoumakpayiMarilène PaquetPier Paolo PandolfiAnne-Marie Mes-MassonFred SaadJody HaighMaxime Bouchard

A1 Journal Article in HUMAN MOLECULAR GENETICS

Identification of a clonally expanding haematopoietic compartment in bone marrow

Lin WangRui BeneditoM Gabriele BixelDagmar ZeuschnerMartin StehlingLars SävendahlJody HaighHugo SnippertHans CleversGeorg Breier et al.

A1 Journal Article in EMBO JOURNAL

Mice overexpressing β-1,4-galactosyltransferase I are resistant to TNF-induced inflammation and DSS-induced colitis

Valerie VanhoorenRoosmarijn VandenbrouckeSylviane DewaeleEvelien Van HammeJody HaighTino HochepiedClaude Libert

A1 Journal Article in PLOS ONE

The ROSA26-iPSC mouse : a conditional, inducible, and exchangeable resource for studying cellular (de)differentiation

Lieven HaenebalckeSteven GoossensPieterjan DierickxSona BartunkovaJinke D'HontKatharina HaighTino HochepiedDagmar WirthAndras NagyJody Haigh

A1 Journal Article in CELL REPORTS

The p53 family and VEGF regulation: 'It's complicated'

Morvarid Farhang GhahremaniSteven GoossensJody Haigh

Editorial material

p53 promotes VEGF expression and angiogenesis in the absence of an intact p21-Rb pathway

Morvarid Farhang GhahremaniSteven GoossensD NittnerX BisteauSona BartunkovaA ZwolinskaPaco HulpiauKatharina HaighLieven HaenebalckeBenjamin Drogat et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2012

Efficient and user-friendly pluripotin-based derivation of mouse embryonic stem cells

Tim PietersLieven HaenebalckeTino HochepiedJinke D'HontJody HaighFrans Van RoyJolanda van Hengel

A1 Journal Article in STEM CELL REVIEWS AND REPORTS

Formation of the collateral circulation is regulated by vascular endothelial growth factor-A and a disintegrin and metalloprotease family members 10 and 17

Jennifer L LucittiJessica K MackeyJeffrey C MorrisonJody HaighRalf H AdamsJames E Faber

A1 Journal Article in CIRCULATION RESEARCH

Generation and use of novel ROSA26-based ESC/iPSC technologies to study cellular reprogramming and gene function during lineage-directed differentiation

Lieven HaenebalckeJody HaighAnne De Paepe

MDM4 is a key therapeutic target in cutaneous melanoma

Agnieszka GembarskaFlavie LucianiClare FedeleElisabeth A RussellMichael DewaeleStéphanie VillarAleksandra ZwolinskaSue HauptJob de LangeDana Yip et al.

A1 Journal Article in NATURE MEDICINE

Molecular and genetic interplay between p53 and VEGF in tumour angiogenesis

Morvarid Farhang GhahremaniJody HaighJean-Christophe Marine

Opposing roles for Hoxa2 and Hoxb2 in hindbrain oligodendrocyte patterning

Andrés MiguezSébastien DucretThomas Di MeglioCarlos ParrasHatem HmidanCéline HatonSowmya SekizarAbdelkrim ManniouiMarie VidalAurélien Kerever et al.

A1 Journal Article in JOURNAL OF NEUROSCIENCE

The role of EMT modulators in hematopoiesis and leukemic transformation

Steven GoossensJody Haigh

Bookchapter in Hematology : science and practice

Tissue-wide overexpression of alpha-T-catenin results in aberrant trophoblast invasion but does not cause embryonic mortality in mice

Koen TybergheinSteven GoossensJody HaighFrans Van RoyJolanda van Hengel

A1 Journal Article in PLACENTA

VEGF-independent cell-autonomous functions of HIF-1α regulating oxygen consumption in fetal cartilage are critical for chondrocyte survival

Christa MaesElisa AraldiKatharina HaighRicha KhatriRiet Van LooverenAmato J GiacciaJody HaighGeert CarmelietErnestina Schipani

A1 Journal Article in JOURNAL OF BONE AND MINERAL RESEARCH

2011

A vascular niche and a VEGF-Nrp1 loop regulate the initiation and stemness of skin tumours

Benjamin BeckGregory DriessensSteven GoossensKhalil Kass YoussefAnna KuchnioAmélie CaauwePanagiota A SotiropoulouSonja LogesGaelle LapougeAurélie Candi et al.

A1 Journal Article in NATURE

Neuronal FLT1 receptor and its selective ligand VEGF-B protect against retrograde degeneration of sensory neurons

Joke DhondtEve PeeraerAn VerheyenRony NuydensIan BuysschaertKoen PoesenKatie Van GeyteManu BeerensMasabumi ShibuyaJody Haigh et al.

A1 Journal Article in FASEB JOURNAL

The EMT regulator Zeb2/Sip1 is essential for murine embryonic hematopoietic stem/progenitor cell differentiation and mobilization

Steven GoossensViktor JanzenSona BartunkovaTomomasa YokomizoBenjamin DrogatMihaela CrisanKatharina HaighEve SeuntjensLieve UmansTamara Riedt et al.

A1 Journal Article in BLOOD

VEGF mediates commissural axon chemoattraction through its receptor Flk1

Carmen Ruiz de AlmodovarPierre J FabreEllen KnevelsCathy CoulonInmaculada SeguraPatrick CG HaddickLiesbeth AertsNicolas DelattinGeraldine StrasserWon-Jong Oh et al.

A1 Journal Article in NEURON

2010

Identification of a co-activator that links growth factor signalling to c-Jun/AP-1 activation

Clare C DaviesAtanu ChakrabortyFilippo CiprianiKatharina HaighJody HaighAxel Behrens

A1 Journal Article in NATURE CELL BIOLOGY

Impaired autonomic regulation of resistance arteries in mice with low vascular endothelial growth factor or upon vascular endothelial growth factor trap delivery

Erik StorkebaumCarmen Ruiz de AlmodovarMerlijn MeensSerena ZacchignaMassimiliano MazzoneGreet VanhoutteStefan VinckierKatarzyna MiskiewiczKoen PoesenDiether Lambrechts et al.

A1 Journal Article in CIRCULATION

Increased skeletal VEGF enhances β-catenin activity and results in excessively ossified bones

Christa MaesSteven GoossensSona BartunkovaBenjamin DrogatLieven CoenegrachtsIngrid StockmansKaren MoermansOmar NyabiKatharina HaighMichaël Naessens et al.

A1 Journal Article in EMBO JOURNAL

Matrix-binding vascular endothelial growth factor (VEGF) isoforms guide granule cell migration in the cerebellum via VEGF receptor Flk1

Carmen Ruiz de AlmodovarCathy CoulonPaul Antoine SalinEllen KnevelsNaura ChounlamountriKoen PoesenKarlien HermansDiether LambrechtsKatie Van GeyteJoke Dhondt et al.

A1 Journal Article in JOURNAL OF NEUROSCIENCE

VEGFR2 (KDR/Flk1) signaling mediates axon growth in response to semaphorin 3E in the developing brain

Anaïs BellonJonathan LuchinoKatharina HaighGeneviève RougonJody HaighSophie ChauvetFanny Mann

A1 Journal Article in NEURON

Vegf regulates embryonic erythroid development through Gata1 modulation

Benjamin DrogatJoanna KaluckaLaura GutierrezHamida HammadSteven GoossensMorvarid Farhang GhahremaniSona BartunkovaKatharina HaighKim DeswarteOmar Nyabi et al.

A1 Journal Article in BLOOD

Widespread overexpression of epitope-tagged Mdm4 does not accelerate tumor formation in vivo

Sarah De ClercqAgniezska GembarskaGeertrui DeneckerMarion MaetensMichaël NaessensKatharina HaighJody HaighJean-Christophe Marine

A1 Journal Article in MOLECULAR AND CELLULAR BIOLOGY

2009

Efficient mouse transgenesis using Gateway-compatible ROSA26 locus targeting vectors and F1 hybrid ES cells

Omar NyabiMichaël NaessensKatharina HaighAgnieszka GembarskaSteven GoossensMarion MaetensSarah De ClercqBenjamin DrogatLieven HaenebalckeSona Bartunkova et al.

A1 Journal Article in NUCLEIC ACIDS RESEARCH

2008

Terminal end bud maintenance in mammary gland is dependent upon FGFR2b signaling

S PARSASK RAMASAMYS DE LANGHEVV GUPTEJody HaighD MEDINAS BELLUSCI

A1 Journal Article in DEVELOPMENTAL BIOLOGY

The role of VEGF in organogenesis

A2 Journal Article in Organogenesis

2007

Developmental and adult phenotyping directly from mutant embryonic stem cells

Sophia HL GeorgeMarina GertsensteinKristina VinterstenElla Korets-SmithJohn MurphyMary E StevensJody HaighAndras Nagy

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhanced natural-killer cell and erythropoietic activities in VEGF-A-overexpressing mice delay F-MuLU-induced erythroleukemia

David CerviYuval ShakedMehran HaeriTatiana UsenkoChristina R LeeJody HaighAndras NagyRobert S KerbelEtan YefenofYaacov Ben-David

A1 Journal Article in BLOOD

VEGF is a novel guidance cue for the initiation of granule cell radial migration

C RUIZ DE ALMODOVARC MEISSIRELP SALINN CHOUNLAMOUNTRIM MUTINE STORKEBAUMU ERIKSSONJody HaighMF BELINL MOONS et al.

2006

Direct evidence for endothelial vascular endothelial growth factor receptor-1 function in nitric oxide-mediated angiogenesis

S AHMADPW HEWETTP WANGB AL-ANIM CUDMORET FUJISAWAJody HaighF LE NOBLEL WANGD MUKHOPADHYAY et al.

A1 Journal Article in CIRCULATION RESEARCH

Non-angiogenic functions of VEGF

Jody HaighC RUIZ DE ALMODOVARM SCHNEIDERP CARMELIET

Bookchapter in Angiogenesis: From basic science to clinical applications

Vascular endothelial growth factor A signaling in the podocyte-endothelial compartment is required for mesangial cell migration and survival

V EREMINASY CUIH GERBERN FERRARAJody HaighA NAGYM EMAJ ROSSANTS JOTHYJH MINER et al.

A1 Journal Article in JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Vascular endothelial growth factor directly inhibits primitive neural stem cell survival but promotes definitive neural stem cell survival

T WadaJody HaighM EmaS HitoshiR ChaddahJ RossantA NagyD van der Kooy

A1 Journal Article in JOURNAL OF NEUROSCIENCE

2005

Aberrant bone formation in mice over-expressing specific VEGF isoforms in cartilage.

C MAESJody HaighA CHANKatharina HaighR BOUILLONG CARMELIETA NAGY

Conditional and inducible transgene expression in mice through the combinatorial use of Cre-mediated recombination and tetracycline induction

Gusztav BeltekiJody HaighNikolett KabacsKatharina HaighKaren SisonFrank CostantiniJeff WhitsettSusan E QuagginAndras Nagy

A1 Journal Article in NUCLEIC ACIDS RESEARCH

2004

Activated Fps/Fes partially rescues the in vivo developmental potential of Flk1-deficient vascular progenitor cells

Jody HaighM EmaK HaighM GertsensteinP GreerJ RossantA NagyEF Wagner

A1 Journal Article in BLOOD

Cre recombinase specificity defined by the tau locus

E Korets-SmithL LindemannKL TuckerCY JiangN KabacsG BeltekiJody HaighM GertsensteinA Nagy

A1 Journal Article in GENESIS

Loss of vascular endothelial growth factor A activity in murine epidermal keratinocytes delays wound healing and inhibits tumor formation

H RossiterC BarresiJ PammerM RendlJody HaighEF WagnerE Tschachler

A1 Journal Article in CANCER RESEARCH

2003

Cortical and retinal defects caused by dosage-dependent reductions in VEGF-A paracrine signaling

Jody HaighPaula I MorelliHolger GerhardtKatharina HaighJohn TsienAnnette DamertLucile MiquerolUlrich MuhlnerRudiger KleinNapoleone Ferrara et al.

A1 Journal Article in DEVELOPMENTAL BIOLOGY

Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases

Vera EreminaManish SoodJody HaighAndrás NagyGinette LajoieNapoleone FerraraHans-Peter GerberYamato KikkawaJeffrey H MinerSusan E Quaggin

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

Impaired intervertebral disc formation in the absence of Jun

Axel BehrensJody HaighFatima Mechta-GrigoriouAndras NagyMoshe YanivErwin F Wagner

A1 Journal Article in DEVELOPMENT

2001

Hyperglycemia-induced vasculopathy in the murine conceptus is mediated via reductions of VEGF-A expression and VEGF receptor activation

E PinterJody HaighA NagyJA Madri

A1 Journal Article in AMERICAN JOURNAL OF PATHOLOGY

2000

Conditional inactivation of VEGF-A in areas of collagen2a1 expression results in embryonic lethality in the heterozygous state

Jody HaighHans-Peter GerberNapoleone FerraraErwin F Wagner

A1 Journal Article in DEVELOPMENT

1996

The fps/fes tyrosine kinase is expressed in myeloid, vascular endothelial, epithelial, and neuronal cells and is localized in the trans-Golgi network

Jody HaighJennifer McVeighPeter Greer

A1 Journal Article in CELL GROWTH & DIFFERENTIATION

1994

The Fps/Fes protein-tyrosine kinase promotes angiogenesis in transgenic mice

Peter GreerJody HaighGeraldine MbamaluWilson KhooAlan BernsteinTony Pawson

A1 Journal Article in MOLECULAR AND CELLULAR BIOLOGY