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Researcher
Jens Staal
Profile
Projects
Publications
Activities
Awards & Distinctions
76
Results
2024
Chimeric and mutant CARD9 constructs enable analyses of conserved and diverged autoinhibition mechanisms in the CARD-CC protein family
Jens Staal
Yasmine Driege
Femke Van Gaever
Jill Steels
Rudi Beyaert
A1
Journal Article
in
FEBS JOURNAL
2024
2023
Mitochondrial dysfunction in inflammation and autoimmunity
Jens Staal
Luz Blanco
Andras Perl
Editorial material
2023
Normal lymphocyte homeostasis and function in MALT1 protease-resistant HOIL-1 knock-in mice
Ioannis Skordos
Yasmine Driege
Mira Haegman
Marja Kreike
Jens Staal
Annelies Demeyer
Rudi Beyaert
A1
Journal Article
in
FEBS JOURNAL
2023
2022
BioArchLinux : bioinformatics community with Arch Linux
Guoyi Zhang
Yujin Hu
Viktor Drobot
Jens Staal
Yun Yi
Michael Elliot
C3
Conference
2022
CARD14 signalling ensures cell survival and cancer associated gene expression in prostate cancer cells
Domien Vanneste
Jens Staal
Mira Haegman
Yasmine Driege
Marieke Carels
Elien Van Nuffel
Pieter De Bleser
Yvan Saeys
Rudi Beyaert
Inna Afonina
A1
Journal Article
in
BIOMEDICINES
2022
Editorial : protein phosphorylation and dephosphorylation in plant-microbe interactions
Jianbin Su
Yi-Ju Lu
Jens Staal
Agnieszka Ludwikow
Editorial material
2022
Engineering a highly sensitive biosensor for abscisic acid in mammalian cells
Seo Woo Kim
Kûbra Alci
Femke Van Gaever
Yasmine Driege
Keylla Bicalho
Geert Goeminne
Claude Libert
Alain Goossens
Rudi Beyaert
Jens Staal
A1
Journal Article
in
FEBS LETTERS
2022
GTF3A mutations predispose to herpes simplex encephalitis by disrupting biogenesis of the host-derived RIG-I ligand RNA5SP141
Leslie Naesens
Santoshi Muppala
Dhiraj Acharya
Josephine Nemegeer
Delfien Bogaert
Jung-Hyun Lee
Katrien Staes
Veronique Debacker
Pieter De Bleser
Marieke De Bruyne
et al.
A1
Journal Article
in
SCIENCE IMMUNOLOGY
2022
Unraveling the functional roles of endogenous phytohormones in mammals
Seo Woo Kim
Rudi Beyaert
Alain Goossens
Jens Staal
Dissertation
2022
2021
Cyclin D2 overexpression drives B1a-derived MCL-like lymphoma in mice
Tim Pieters
Sara T'Sas
Stijn Vanhee
André Pedro Pinto De Almeida
Yasmine Driege
Juliette Roels
Wouter Van Loocke
Willem Daneels
Mathijs Baens
Arnaud Marchand
et al.
A1
Journal Article
in
JOURNAL OF EXPERIMENTAL MEDICINE
2021
Defining the combinatorial space of PKC::CARD-CC signal transduction nodes
Jens Staal
Yasmine Driege
Mira Haegman
Marja Kreike
Styliani Iliaki
Domien Vanneste
Marie Lork
Inna Afonina
Harald Braun
Rudi Beyaert
A1
Journal Article
in
FEBS JOURNAL
2021
GTF3A mutations in a patient with herpes simplex encephalitis reveals a novel role in viral immunity by transcribing 5S rRNA pseudogenes serving as RIG-I ligands
Leslie Naesens
Santoshi Muppala
Jung-Hyun Lee
Josephine Nemegeer
Dhiraj Acharya
Delfien Bogaert
Michiel van Gent
Jens Staal
Katrien Staes
Veronique Debacker
et al.
C3
Conference
2021
2020
Classification and nomenclature of metacaspases and paracaspases : no more confusion with caspases
Elena A. Minina
Jens Staal
Vanina E. Alvarez
John A. Berges
Ilana Berman-Frank
Rudi Beyaert
Kay D. Bidle
Frédéric Bornancin
Magali Casanova
Juan J. Cazzulo
et al.
A1
Journal Article
in
MOLECULAR CELL
2020
Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome
Vivien Béziat
Simon Tavernier
Yin-Huai Chen
Cindy S. Ma
Marie Materna
Arian Laurence
Jens Staal
Dominik Aschenbrenner
Lisa Roels
Lisa Worley
et al.
A1
Journal Article
in
JOURNAL OF EXPERIMENTAL MEDICINE
2020
Fytohormonen : verschillende bioactieve moleculen die metabolisme en ontsteking beïnvloeden in de mens
Jens Staal
A4
Journal Article
in
BLOEDVATEN, HART, LONGEN
2020
Long-term MALT1 inhibition in adult mice without severe systemic autoimmunity
Annelies Demeyer
Yasmine Driege
Ioannis Skordos
Julie Coudenys
Kelly Lemeire
Dirk Elewaut
Jens Staal
Rudi Beyaert
A1
Journal Article
in
ISCIENCE
2020
MALT1 targeting suppresses CARD14‐induced psoriatic dermatitis in mice
Elien Van Nuffel
Jens Staal
Griet Baudelet
Mira Haegman
Yasmine Driege
Tino Hochepied
Inna Afonina
Rudi Beyaert
A1
Journal Article
in
EMBO REPORTS
2020
Phytohormones : diverses molécules bioactives influant sur le métabolisme et l’inflammation chez l’homme
Jens Staal
A4
Journal Article
in
VAISSEAUX, COEUR, POUMONS
2020
Phytohormones : multifunctional nutraceuticals against metabolic syndrome and comorbid diseases
Seo Woo Kim
Alain Goossens
Claude Libert
Filip Van Immerseel
Jens Staal
Rudi Beyaert
A1
Journal Article
in
BIOCHEMICAL PHARMACOLOGY
2020
Stabilization of the TAK1 adaptor proteins TAB2 and TAB3 is critical for optimal NF-kappa B activation
Harald Braun
Jens Staal
Editorial material
2020
2019
A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation
Simon Tavernier
V Athanasopoulos
PATRICK VERLOO
G Behrens
Jens Staal
Delfien Bogaert
Leslie Naesens
Marieke De Bruyne
Sofie Van Gassen
Eef Parthoens
et al.
A1
Journal Article
in
NATURE COMMUNICATIONS
2019
Artistic research in breeding : the Bifrost Eucalyptus project
Jens Staal
Preprint
2019
Deletion of mucosa-associated lymphoid tissue lymphoma translocation protein 1 in mouse T cells protects against development of autoimmune arthritis but leads to spontaneous osteoporosis
Elisabeth Gilis
Djoere Gaublomme
Jens Staal
Koen Venken
Maarten Dhaenens
Stijn Lambrecht
Julie Coudenys
Tine Decruy
Nadia Schryvers
Yasmine Driege
et al.
A1
Journal Article
in
ARTHRITIS & RHEUMATOLOGY
2019
Engineering a minimal cloning vector from a pUC18 plasmid backbone with an extended multiple cloning site
Jens Staal
Kûbra Alci
Wouter De Schamphelaire
Martine Vanhoucke
Rudi Beyaert
A1
Journal Article
in
BIOTECHNIQUES
2019
MALT1 proteolytic activity suppresses autoimmunity in a T cell intrinsic manner
Annelies Demeyer
Ioannis Skordos
Yasmine Driege
Marja Kreike
Tino Hochepied
Mathijs Baens
Jens Staal
Rudi Beyaert
A1
Journal Article
in
FRONTIERS IN IMMUNOLOGY
2019
MALT1-deficient mice develop atopic-like dermatitis upon aging
Annelies Demeyer
Elien Van Nuffel
Griet Baudelet
Yasmine Driege
Marja Kreike
David Muyllaert
Jens Staal
Rudi Beyaert
A1
Journal Article
in
FRONTIERS IN IMMUNOLOGY
2019
Molecular regulation of T cell receptor signaling
Marie Lork
Rudi Beyaert
Jens Staal
Dissertation
2019
Ubiquitination and phosphorylation of the CARD11-BCL10-MALT1 signalosome in T cells
Marie Lork
Jens Staal
Rudi Beyaert
A1
Journal Article
in
CELLULAR IMMUNOLOGY
2019
2018
A CARD9 founder mutation disrupts NF-κB signaling by inhibiting BCL10 and MALT1 recruitment and signalosome formation
Marieke De Bruyne
Levi Hoste
Delfien Bogaert
Lien Van den Bossche
Simon Tavernier
Eef Parthoens
Mélanie Migaud
Deborah Konopnicki
Jean Cyr Yombi
Bart Lambrecht
et al.
A1
Journal Article
in
FRONTIERS IN IMMUNOLOGY
2018
Ancient origin of the CARD-coiled coil/Bcl10/MALT1-like paracaspase signaling complex indicates unknown critical functions
Jens Staal
Yasmine Driege
Mira Haegman
Alice Borghi
Paco Hulpiau
Laurens Lievens
Ismail Sahin Gül
Srividhya Sundararaman Iyer
Amanda Gonçalves
Ineke Dhondt
et al.
A1
Journal Article
in
FRONTIERS IN IMMUNOLOGY
2018
Engineering a minimal cloning vector from a pUC18 plasmid backbone with an extended multiple cloning site
Jens Staal
Wouter De Schamphelaire
Rudi Beyaert
Other
2018
GC content of Early Metazoan genes and its impact on gene expression levels in mammalian cell lines
Ismail Sahin Gül
Jens Staal
Paco Hulpiau
Evi De Keuckelaere
Kai Kamm
Tom Deroo
Ellen Sanders
Katrien Staes
Yasmine Driege
Yvan Saeys
et al.
A1
Journal Article
in
GENOME BIOLOGY AND EVOLUTION
2018
Importance of validating antibodies and small compound inhibitors using genetic knockout studies : T cell receptor-induced CYLD phosphorylation by IKKε/TBK1 as a case study
Marie Lork
Marja Kreike
Jens Staal
Rudi Beyaert
A1
Journal Article
in
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
2018
Inflammation and NF-κB signaling in prostate cancer : mechanisms and clinical implications
Jens Staal
Rudi Beyaert
A1
Journal Article
in
CELLS
2018
Inhibition of MALT1 decreases neuroinflammation and pathogenicity of virulent rabies virus in mice
Elodie Kip
Jens Staal
HG Tima
Lynn Verstrepen
M Romano
Kelly Lemeire
V Suin
A Hamouda
M Baens
Claude Libert
et al.
A1
Journal Article
in
JOURNAL OF VIROLOGY
2018
MALT1 controls attenuated rabies virus by inducing early inflammation and T cell activation in the brain
Elodie Kip
Jens Staal
Lynn Verstrepen
HG Tima
S Terryn
M Romano
Kelly Lemeire
V Suin
A Hamouda
M Kalai
et al.
A1
Journal Article
in
JOURNAL OF VIROLOGY
2018
Mepazine inhibits RANK-induced osteoclastogenesis independent of its MALT1 inhibitory function
Laura Meloni
Lynn Verstrepen
Marja Kreike
Jens Staal
Yasmine Driege
Inna Afonina
Rudi Beyaert
A1
Journal Article
in
MOLECULES
2018
2017
A CARD9 Turkisch founder mutation disrupts NF-κB signaling by inhibiting Bcl10 recruitment
Marieke De Bruyne
Levi Hoste
Delfien Bogaert
Mélanie Migaud
Deborah Konopnicki
Bart Lambrecht
Rudi Beyaert
Elfride De Baere
Anne Puel
Jean-Christophe Goffard
et al.
C3
Conference
2017
Abscisic acid as pathogen effector and immune regulator
Laurens Lievens
Jacob Pollier
Alain Goossens
Rudi Beyaert
Jens Staal
A1
Journal Article
in
FRONTIERS IN PLANT SCIENCE
2017
Applied cultural and social studies are needed for a sustainable reduction of genetic disease incidence
Jens Staal
A2
Journal Article
in
EUROPEAN JOURNAL OF SOCIOLOGY AND ANTHROPOLOGY
2017
CARD9 p.R70W, a Turkish founder mutation associated with mucosal and invasive fungal infections, disrupts downstream NF-κB signaling by inhibiting Bcl10 recruitment
Marieke De Bruyne
Delfien Bogaert
Levi Hoste
Mélanie Migaud
Jean-Christophe Goffard
Deborah Konopnicki
Bart Lambrecht
Rudi Beyaert
Elfride De Baere
Anne Puel
et al.
C3
Conference
2017
CARD9 p.R70W, a Turkish founder mutation associated with mucosal and invasive fungal infections, disrupts downstream NF-κB signaling by inhibiting Bcl10 recruitment
Marieke De Bruyne
Delfien Bogaert
Levi Hoste
Mélanie Migaud
Jean-Christophe Goffard
Deborah Konopnicki
Bart Lambrecht
Rudi Beyaert
Elfride De Baere
Anne Puel
et al.
C3
Conference
2017
CARD9 p.R70W, a Turkish founder mutation associated with mucosal and invasive fungal infections, disrupts downstream NF-κB signaling by inhibiting Bcl10 recruitment
Marieke De Bruyne
Levi Hoste
Delfien Bogaert
Mélanie Migaud
Jean-Christophe Goffard
Deborah Konopnicki
Bart Lambrecht
Rudi Beyaert
Elfride De Baere
Anne Puel
et al.
C3
Conference
2017
The paracaspase MALT1 plays a central role in the pathogenesis of rheumatoid arthritis
Elisabeth Gilis
Jens Staal
Rudi Beyaert
Dirk Elewaut
C3
Conference
2017
2016
Functional characterization of the paracaspase MALT1 in T cells
Annelies Demeyer
Rudi Beyaert
Jens Staal
Dissertation
2016
MALT1 cleaves the E3 ubiquitin ligase HOIL-1 in activated T cells, generating a dominant negative inhibitor of LUBAC-induced NF-κB signaling
Lynn Elton
Isabelle Carpentier
Jens Staal
Yasmine Driege
Mira Haegman
Rudi Beyaert
A1
Journal Article
in
FEBS JOURNAL
2016
MALT1 contributes to the pathogenicity of the virulent rabies virus CVS-11 in mice
Elodie Kip
Vanessa Suin
Jens Staal
Rudi Beyaert
Steven Van Gucht
C3
Conference
2016
MALT1 is not alone after all : identification of novel paracaspases
Paco Hulpiau
Yasmine Driege
Jens Staal
Rudi Beyaert
A1
Journal Article
in
CELLULAR AND MOLECULAR LIFE SCIENCES
2016
NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNF AIP3/A20
Michael Drennan
Srinath Govindarajan
Eveline Verheugen
Jonathan Coquet
Jens Staal
Conor Mc Guire
Tom Taghon
Georges Leclercq
Rudi Beyaert
Geert van Loo
et al.
A1
Journal Article
in
JOURNAL OF EXPERIMENTAL MEDICINE
2016
Targeting MALT1 proteolytic activity in immunity, inflammation and disease: good or bad?
Annelies Demeyer
Jens Staal
Rudi Beyaert
A1
Journal Article
in
TRENDS IN MOLECULAR MEDICINE
2016
The paracaspase MALT1 mediates CARD14-induced signaling in keratinocytes
Inna Afonina
Elien Van Nuffel
Griet Baudelet
Yasmine Driege
Marja Kreike
Jens Staal
Rudi Beyaert
A1
Journal Article
in
EMBO REPORTS
2016
2015
A novel STAT1 mutation in a patient with pneumocystis jiroveci and chronic mucocutaneous candidiasis
Delfien Bogaert
Melissa Dullaers
Jens Staal
Sarah Gerlo
Elien Vandermarliere
Veronique De Backer
Victoria Bordon Maria
KATHLEEN DE WAELE
Isabelle Meyts
Leen Moens
et al.
C3
Conference
2015
The multifaceted role of the E3 ubiquitin ligase HOIL-1: beyond linear ubiquitination
Lynn Elton
Isabelle Carpentier
Kelly Verhelst
Jens Staal
Rudi Beyaert
A1
Journal Article
in
IMMUNOLOGICAL REVIEWS
2015
2014
A novel Stat1 mutation leading to hyperphosphorylation in a patient with Pneumocystis jjiroveci and chronic mucocutaneous candidiasis
Melissa Dullaers
Jens Staal
Sarah Gerlo
Elien Vandermarliere
V Debacker
Victoria Bordon Maria
K De Waele
I Meyts
L Moens
X Bossuyt
et al.
C3
Conference
2014
Identification and functional characterization of novel MALT1 substrates
Lynn Elton
Rudi Beyaert
Jens Staal
Dissertation
2014
Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis
Conor Mc Guire
Lynn Elton
Peter Wieghofer
Jens Staal
Sofie Voet
Annelies Demeyer
Daniel Nagel
Daniel Krappmann
Marco Prinz
Rudi Beyaert
et al.
A1
Journal Article
in
JOURNAL OF NEUROINFLAMMATION
2014
2013
A novel role of PR2 in abscisic acid (ABA) mediated, pathogen-induced callose deposition in Arabidopsis thaliana
Shinichi Oide
Sarosh Bejai
Jens Staal
Na Guan
Maria Kaliff
Christina Dixelius
A1
Journal Article
in
NEW PHYTOLOGIST
2013
2012
A two-step activation mechanism of MALT1 paracaspase
Jens Staal
Rudi Beyaert
Editorial material
2012
2011
Regulation of NF-κB signaling by caspases and MALT1 paracaspase
Jens Staal
Tine Bekaert
Rudi Beyaert
A1
Journal Article
in
CELL RESEARCH
2011
T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1
Jens Staal
Yasmine Driege
Tine Bekaert
Annelies Demeyer
David Muyllaert
Petra Van Damme
Kris Gevaert
Rudi Beyaert
A1
Journal Article
in
EMBO JOURNAL
2011
2010
Cleavage by MALT1 induces cytosolic release of A20
Claire Malinverni
Adeline Unterreiner
Jens Staal
Annelies Demeyer
Marion Galaup
Marcel Luyten
Rudi Beyaert
Frédéric Bornancin
A1
Journal Article
in
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2010
2009
Layers of defense responses to Leptosphaeria maculans below the RLM1- and camalexin-dependent resistances
Mattias Persson
Jens Staal
Shinichi Oide
Christina Dixelius
A1
Journal Article
in
NEW PHYTOLOGIST
2009
Plant innate immunity
Jens Staal
Christina Dixelius
Bookchapter
in
Encyclopedia of life sciences
2009
2008
Prolonged exposure to IL-1 beta and IFN gamma induces necrosis of L929 tumor cells via a p38MAPK/NF-kappa B/NO-dependent mechanism
Elisabeth Vercammen
Jens Staal
Aeke Van Den Broeke
Mira Haegman
Lars Vereecke
Peter Schotte
Rudi Beyaert
A1
Journal Article
in
ONCOGENE
2008
RLM3, a TIR domain encoding gene involved in broad-range immunity of Arabidopsis to necrotrophic fungal pathogens
Jens Staal
M KALIFF
E DEWAELE
M PERSSON
C DIXELIUS
A1
Journal Article
in
PLANT JOURNAL
2008
RLM3, a potential adaptor between specific TIR-NB-LRR receptors and DZC proteins
Jens Staal
Christina Dixelius
A2
Journal Article
in
COMMUNICATIVE & INTEGRATIVE BIOLOGY
2008
Sensing of viral infection and activation of innate immunity by toll-like receptor 3
Elisabeth Vercammen
Jens Staal
Rudi Beyaert
A1
Journal Article
in
CLINICAL MICROBIOLOGY REVIEWS
2008
T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappa B inhibitor A20
Beatrice Coornaert
M BAENS
Karen Heyninck
Tine Bekaert
Mira Haegman
Jens Staal
LJ SUN
ZJJ CHEN
P MARYNEN
Rudi Beyaert
A1
Journal Article
in
NATURE IMMUNOLOGY
2008
2007
ABA is required for Leptosphaeria maculans resistance via ABI1- and ABI4-dependent signaling
Maria Kaliff
Jens Staal
Mattias Myrenås
Christina Dixelius
A1
Journal Article
in
MOLECULAR PLANT-MICROBE INTERACTIONS
2007
Defence components in Arabidopsis against Leptosphaeria maculans
Jens Staal
Maria Kaliff
Mattias Persson
Christina Dixelius
C3
Conference
2007
Tracing the ancient origins of plant innate immunity
Jens Staal
C DIXELIUS
A1
Journal Article
in
TRENDS IN PLANT SCIENCE
2007
2006
Early responses in the Arabidopsis-verticillium longisporum pathosystem are dependent on NDR1, JA- and ET-associated signals via cytosolic NPR1 and RFO1
Anna Johansson
Jens Staal
Christina Dixelius
A1
Journal Article
in
MOLECULAR PLANT-MICROBE INTERACTIONS
2006
Genes and mechanisms in Arabidopsis innate immunity against Leptosphaeria maculans
Jens Staal
Christina Dixelius
Dissertation
2006
Liten kusin från labbet räddar rapsen från röta
Jens Staal
Blog post
2006
Transgressive segregation reveals two Arabidopsis TIR-NB-LRR resistance genes effective against Leptosphaeria maculans, causal agent of blackleg disease
Jens Staal
Maria Kaliff
Svante Bohman
Christina Dixelius
A1
Journal Article
in
PLANT JOURNAL
2006
2004
Characterisation of an Arabidopsis-Leptosphaeria maculans pathosystem : resistance partially requires camalexin biosynthesis and is independent of salicylic acid, ethylene and jasmonic acid signalling
Svante Bohman
Jens Staal
Bart P. H. J. Thomma
Maolin Wang
Christina Dixelius
A1
Journal Article
in
PLANT JOURNAL
2004