Research Explorer

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Researcher

Jens Staal

Publications & Research Data

Awards & Distinctions

88 Results

2026

Development and validation of a flow cytometry-based ISG15 induction assay to monitor the type I interferon response

Birthe MichielsRudi BeyaertJens StaalDoreen DillaertsMaaike CockxGlynis FransBirgit TimmermansNatalie LorentIsabelle MeytsXavier Bossuyt

A1 Journal Article in CLINICAL IMMUNOLOGY

2025

BioArchLinux : community-driven fresh reproducible software repository for life sciences

Guoyi ZhangPekka RistolaHan SuBipin KumarBoyu ZhangYujin HuMichael G. ElliotViktor DrobotJie ZhuJens Staal et al.

A1 Journal Article in BIOINFORMATICS

Multi-step pathway engineering in probiotic Saccharomyces boulardii for abscisic acid production in the gut

Femke Van GaeverPaul VandecruysYasmine DriegeSeo Woo KimJohan M. TheveleinRudi BeyaertJens Staal

A2 Journal Article in METABOLIC ENGINEERING COMMUNICATIONS

Replication stress, microcephalic primordial dwarfism, and compromised immunity in ATRIP deficient patients

Evi DuthooElien BeylsLynn BackersThorkell GudjónssonPeiquan HuangLeander JonckheereSebastian RiemannBram PartonLikun DuVeronique Debacker et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Role of MALT1 substrate cleavage in immune regulation : insights from a mouse gene targeting approach

Ioannis SkordosRudi BeyaertAnnelies DemeyerJens Staal

2024

Chimeric and mutant CARD9 constructs enable analyses of conserved and diverged autoinhibition mechanisms in the CARD-CC protein family

Jens StaalYasmine DriegeFemke Van GaeverJill SteelsRudi Beyaert

A1 Journal Article in FEBS JOURNAL

Engineering of an abscisic acid-producing saccharomyces boulardii strain and analysis of its therapeutic potential in preclinical models of inflammation

Femke Van GaeverRudi BeyaertJens Staal

The phytohormone abscisic acid enhances remyelination in mouse models of multiple sclerosis

Femke Van GaeverFleur MingneauSam VanherleYasmine DriegeMira HaegmanElien Van WonterghemJunhua XieRoosmarijn VandenbrouckeJerome J. A. HendriksRudi Beyaert et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

2023

CARD10/CARD14 heterodimer

Dimeric CARD10 model

Dimeric CARD11 model

Dimeric CARD14 model

Dimeric CARD9 model

Mitochondrial dysfunction in inflammation and autoimmunity

Jens StaalLuz BlancoAndras Perl

Editorial material

Normal lymphocyte homeostasis and function in MALT1 protease-resistant HOIL-1 knock-in mice

Ioannis SkordosYasmine DriegeMira HaegmanMarja KreikeJens StaalAnnelies DemeyerRudi Beyaert

A1 Journal Article in FEBS JOURNAL

2022

BioArchLinux : bioinformatics community with Arch Linux

Guoyi ZhangYujin HuViktor DrobotJens StaalYun YiMichael Elliot

CARD14 signalling ensures cell survival and cancer associated gene expression in prostate cancer cells

Domien VannesteJens StaalMira HaegmanYasmine DriegeMarieke CarelsElien Van NuffelPieter De BleserYvan SaeysRudi BeyaertInna Afonina

A1 Journal Article in BIOMEDICINES

Editorial : protein phosphorylation and dephosphorylation in plant-microbe interactions

Jianbin SuYi-Ju LuJens StaalAgnieszka Ludwikow

Editorial material

Engineering a highly sensitive biosensor for abscisic acid in mammalian cells

Seo Woo KimKûbra AlciFemke Van GaeverYasmine DriegeKeylla BicalhoGeert GoeminneClaude LibertAlain GoossensRudi BeyaertJens Staal

A1 Journal Article in FEBS LETTERS

GTF3A mutations predispose to herpes simplex encephalitis by disrupting biogenesis of the host-derived RIG-I ligand RNA5SP141

Leslie NaesensSantoshi MuppalaDhiraj AcharyaJosephine NemegeerDelfien BogaertJung-Hyun LeeKatrien StaesVeronique DebackerPieter De BleserMarieke De Bruyne et al.

A1 Journal Article in SCIENCE IMMUNOLOGY

Unraveling the functional roles of endogenous phytohormones in mammals

Seo Woo KimRudi BeyaertAlain GoossensJens Staal

2021

Cyclin D2 overexpression drives B1a-derived MCL-like lymphoma in mice

Tim PietersSara T'SasStijn VanheeAndré Pedro Pinto De AlmeidaYasmine DriegeJuliette RoelsWouter Van LoockeWillem DaneelsMathijs BaensArnaud Marchand et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Defining the combinatorial space of PKC::CARD-CC signal transduction nodes

Jens StaalYasmine DriegeMira HaegmanMarja KreikeStella IliakiDomien VannesteMarie LorkInna AfoninaHarald BraunRudi Beyaert

A1 Journal Article in FEBS JOURNAL

GTF3A mutations in a patient with herpes simplex encephalitis reveals a novel role in viral immunity by transcribing 5S rRNA pseudogenes serving as RIG-I ligands

Leslie NaesensSantoshi MuppalaJung-Hyun LeeJosephine NemegeerDhiraj AcharyaDelfien BogaertMichiel van GentJens StaalKatrien StaesVeronique Debacker et al.

2020

Classification and nomenclature of metacaspases and paracaspases : no more confusion with caspases

Elena A. MininaJens StaalVanina E. AlvarezJohn A. BergesIlana Berman-FrankRudi BeyaertKay D. BidleFrédéric BornancinMagali CasanovaJuan J. Cazzulo et al.

A1 Journal Article in MOLECULAR CELL

Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome

Vivien BéziatSimon TavernierYin-Huai ChenCindy S. MaMarie MaternaArian LaurenceJens StaalDominik AschenbrennerLisa RoelsLisa Worley et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Fytohormonen : verschillende bioactieve moleculen die metabolisme en ontsteking beïnvloeden in de mens

A4 Journal Article in BLOEDVATEN, HART, LONGEN

Long-term MALT1 inhibition in adult mice without severe systemic autoimmunity

Annelies DemeyerYasmine DriegeIoannis SkordosJulie CoudenysKelly LemeireDirk ElewautJens StaalRudi Beyaert

A1 Journal Article in ISCIENCE

MALT1 targeting suppresses CARD14‐induced psoriatic dermatitis in mice

Elien Van NuffelJens StaalGriet BaudeletMira HaegmanYasmine DriegeTino HochepiedInna AfoninaRudi Beyaert

A1 Journal Article in EMBO REPORTS

Phytohormones : diverses molécules bioactives influant sur le métabolisme et l’inflammation chez l’homme

A4 Journal Article in VAISSEAUX, COEUR, POUMONS

Phytohormones : multifunctional nutraceuticals against metabolic syndrome and comorbid diseases

Seo Woo KimAlain GoossensClaude LibertFilip Van ImmerseelJens StaalRudi Beyaert

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Stabilization of the TAK1 adaptor proteins TAB2 and TAB3 is critical for optimal NF-kappa B activation

Harald BraunJens Staal

Editorial material

2019

A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation

Simon TavernierV AthanasopoulosPATRICK VERLOOG BehrensJens StaalDelfien BogaertLeslie NaesensMarieke De BruyneSofie Van GassenEef Parthoens et al.

A1 Journal Article in NATURE COMMUNICATIONS

Artistic research in breeding : the Bifrost Eucalyptus project

Deletion of mucosa-associated lymphoid tissue lymphoma translocation protein 1 in mouse T cells protects against development of autoimmune arthritis but leads to spontaneous osteoporosis

Elisabeth GilisDjoere GaublommeJens StaalKoen VenkenMaarten DhaenensStijn LambrechtJulie CoudenysTine DecruyNadia SchryversYasmine Driege et al.

A1 Journal Article in ARTHRITIS & RHEUMATOLOGY

Engineering a minimal cloning vector from a pUC18 plasmid backbone with an extended multiple cloning site

Jens StaalKûbra AlciWouter De SchamphelaireMartine VanhouckeRudi Beyaert

A1 Journal Article in BIOTECHNIQUES

MALT1 proteolytic activity suppresses autoimmunity in a T cell intrinsic manner

Annelies DemeyerIoannis SkordosYasmine DriegeMarja KreikeTino HochepiedMathijs BaensJens StaalRudi Beyaert

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

MALT1-deficient mice develop atopic-like dermatitis upon aging

Annelies DemeyerElien Van NuffelGriet BaudeletYasmine DriegeMarja KreikeDavid MuyllaertJens StaalRudi Beyaert

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Molecular regulation of T cell receptor signaling

Marie LorkRudi BeyaertJens Staal

Ubiquitination and phosphorylation of the CARD11-BCL10-MALT1 signalosome in T cells

Marie LorkJens StaalRudi Beyaert

A1 Journal Article in CELLULAR IMMUNOLOGY

2018

A CARD9 founder mutation disrupts NF-κB signaling by inhibiting BCL10 and MALT1 recruitment and signalosome formation

Marieke De BruyneLevi HosteDelfien BogaertLien Van den BosscheSimon TavernierEef ParthoensMélanie MigaudDeborah KonopnickiJean Cyr YombiBart Lambrecht et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Ancient origin of the CARD-coiled coil/Bcl10/MALT1-like paracaspase signaling complex indicates unknown critical functions

Jens StaalYasmine DriegeMira HaegmanAlice BorghiPaco HulpiauLaurens LievensIsmail Sahin GülSrividhya Sundararaman IyerAmanda GonçalvesIneke Dhondt et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Engineering a minimal cloning vector from a pUC18 plasmid backbone with an extended multiple cloning site

Jens StaalWouter De SchamphelaireRudi Beyaert

GC content of Early Metazoan genes and its impact on gene expression levels in mammalian cell lines

Ismail Sahin GülJens StaalPaco HulpiauEvi De KeuckelaereKai KammTom DerooEllen SandersKatrien StaesYasmine DriegeYvan Saeys et al.

A1 Journal Article in GENOME BIOLOGY AND EVOLUTION

Importance of validating antibodies and small compound inhibitors using genetic knockout studies : T cell receptor-induced CYLD phosphorylation by IKKε/TBK1 as a case study

Marie LorkMarja KreikeJens StaalRudi Beyaert

A1 Journal Article in FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

Inflammation and NF-κB signaling in prostate cancer : mechanisms and clinical implications

Jens StaalRudi Beyaert

A1 Journal Article in CELLS

Inhibition of MALT1 decreases neuroinflammation and pathogenicity of virulent rabies virus in mice

Elodie KipJens StaalHG TimaLynn VerstrepenM RomanoKelly LemeireV SuinA HamoudaM BaensClaude Libert et al.

A1 Journal Article in JOURNAL OF VIROLOGY

MALT1 controls attenuated rabies virus by inducing early inflammation and T cell activation in the brain

Elodie KipJens StaalLynn VerstrepenHG TimaS TerrynM RomanoKelly LemeireV SuinA HamoudaM Kalai et al.

A1 Journal Article in JOURNAL OF VIROLOGY

Mepazine inhibits RANK-induced osteoclastogenesis independent of its MALT1 inhibitory function

Laura MeloniLynn VerstrepenMarja KreikeJens StaalYasmine DriegeInna AfoninaRudi Beyaert

A1 Journal Article in MOLECULES

2017

A CARD9 Turkisch founder mutation disrupts NF-κB signaling by inhibiting Bcl10 recruitment

Marieke De BruyneLevi HosteDelfien BogaertMélanie MigaudDeborah KonopnickiBart LambrechtRudi BeyaertElfride De BaereAnne PuelJean-Christophe Goffard et al.

Abscisic acid as pathogen effector and immune regulator

Laurens LievensJacob PollierAlain GoossensRudi BeyaertJens Staal

A1 Journal Article in FRONTIERS IN PLANT SCIENCE

Applied cultural and social studies are needed for a sustainable reduction of genetic disease incidence

A2 Journal Article in EUROPEAN JOURNAL OF SOCIOLOGY AND ANTHROPOLOGY

CARD9 p.R70W, a Turkish founder mutation associated with mucosal and invasive fungal infections, disrupts downstream NF-κB signaling by inhibiting Bcl10 recruitment

Marieke De BruyneDelfien BogaertLevi HosteMélanie MigaudJean-Christophe GoffardDeborah KonopnickiBart LambrechtRudi BeyaertElfride De BaereAnne Puel et al.

CARD9 p.R70W, a Turkish founder mutation associated with mucosal and invasive fungal infections, disrupts downstream NF-κB signaling by inhibiting Bcl10 recruitment

Marieke De BruyneLevi HosteDelfien BogaertMélanie MigaudJean-Christophe GoffardDeborah KonopnickiBart LambrechtRudi BeyaertElfride De BaereAnne Puel et al.

CARD9 p.R70W, a Turkish founder mutation associated with mucosal and invasive fungal infections, disrupts downstream NF-κB signaling by inhibiting Bcl10 recruitment

Marieke De BruyneDelfien BogaertLevi HosteMélanie MigaudJean-Christophe GoffardDeborah KonopnickiBart LambrechtRudi BeyaertElfride De BaereAnne Puel et al.

The paracaspase MALT1 plays a central role in the pathogenesis of rheumatoid arthritis

Elisabeth GilisJens StaalRudi BeyaertDirk Elewaut

2016

Functional characterization of the paracaspase MALT1 in T cells

Annelies DemeyerRudi BeyaertJens Staal

MALT1 cleaves the E3 ubiquitin ligase HOIL-1 in activated T cells, generating a dominant negative inhibitor of LUBAC-induced NF-κB signaling

Lynn EltonIsabelle CarpentierJens StaalYasmine DriegeMira HaegmanRudi Beyaert

A1 Journal Article in FEBS JOURNAL

MALT1 contributes to the pathogenicity of the virulent rabies virus CVS-11 in mice

Elodie KipVanessa SuinJens StaalRudi BeyaertSteven Van Gucht

MALT1 is not alone after all : identification of novel paracaspases

Paco HulpiauYasmine DriegeJens StaalRudi Beyaert

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNF AIP3/A20

Michael DrennanSrinath GovindarajanEveline VerheugenJonathan CoquetJens StaalConor Mc GuireTom TaghonGeorges LeclercqRudi BeyaertGeert van Loo et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Targeting MALT1 proteolytic activity in immunity, inflammation and disease: good or bad?

Annelies DemeyerJens StaalRudi Beyaert

A1 Journal Article in TRENDS IN MOLECULAR MEDICINE

The paracaspase MALT1 mediates CARD14-induced signaling in keratinocytes

Inna AfoninaElien Van NuffelGriet BaudeletYasmine DriegeMarja KreikeJens StaalRudi Beyaert

A1 Journal Article in EMBO REPORTS

2015

A novel STAT1 mutation in a patient with pneumocystis jiroveci and chronic mucocutaneous candidiasis

Delfien BogaertMelissa DullaersJens StaalSarah GerloElien VandermarliereVeronique De BackerMaria Bordon Cueto De BraemKATHLEEN DE WAELEIsabelle MeytsLeen Moens et al.

The multifaceted role of the E3 ubiquitin ligase HOIL-1: beyond linear ubiquitination

Lynn EltonIsabelle CarpentierKelly VerhelstJens StaalRudi Beyaert

A1 Journal Article in IMMUNOLOGICAL REVIEWS

2014

A novel Stat1 mutation leading to hyperphosphorylation in a patient with Pneumocystis jjiroveci and chronic mucocutaneous candidiasis

Melissa DullaersJens StaalSarah GerloElien VandermarliereV DebackerMaria Bordon Cueto De BraemK De WaeleI MeytsL MoensX Bossuyt et al.

Identification and functional characterization of novel MALT1 substrates

Lynn EltonRudi BeyaertJens Staal

Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis

Conor Mc GuireLynn EltonPeter WieghoferJens StaalSofie VoetAnnelies DemeyerDaniel NagelDaniel KrappmannMarco PrinzRudi Beyaert et al.

A1 Journal Article in JOURNAL OF NEUROINFLAMMATION

2013

A novel role of PR2 in abscisic acid (ABA) mediated, pathogen-induced callose deposition in Arabidopsis thaliana

Shinichi OideSarosh BejaiJens StaalNa GuanMaria KaliffChristina Dixelius

A1 Journal Article in NEW PHYTOLOGIST

2012

A two-step activation mechanism of MALT1 paracaspase

Jens StaalRudi Beyaert

Editorial material

2011

Regulation of NF-κB signaling by caspases and MALT1 paracaspase

Jens StaalTine BekaertRudi Beyaert

A1 Journal Article in CELL RESEARCH

T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1

Jens StaalYasmine DriegeTine BekaertAnnelies DemeyerDavid MuyllaertPetra Van DammeKris GevaertRudi Beyaert

A1 Journal Article in EMBO JOURNAL

2010

Cleavage by MALT1 induces cytosolic release of A20

Claire MalinverniAdeline UnterreinerJens StaalAnnelies DemeyerMarion GalaupMarcel LuytenRudi BeyaertFrédéric Bornancin

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

2009

Layers of defense responses to Leptosphaeria maculans below the RLM1- and camalexin-dependent resistances

Mattias PerssonJens StaalShinichi OideChristina Dixelius

A1 Journal Article in NEW PHYTOLOGIST

Plant innate immunity

Jens StaalChristina Dixelius

Bookchapter in Encyclopedia of life sciences

2008

Prolonged exposure to IL-1 beta and IFN gamma induces necrosis of L929 tumor cells via a p38MAPK/NF-kappa B/NO-dependent mechanism

Elisabeth VercammenJens StaalAeke Van Den BroekeMira HaegmanLars VereeckePeter SchotteRudi Beyaert

A1 Journal Article in ONCOGENE

RLM3, a potential adaptor between specific TIR-NB-LRR receptors and DZC proteins

Jens StaalChristina Dixelius

A2 Journal Article in COMMUNICATIVE & INTEGRATIVE BIOLOGY

RLM3, a TIR domain encoding gene involved in broad-range immunity of Arabidopsis to necrotrophic fungal pathogens

Jens StaalM KALIFFE DEWAELEM PERSSONC DIXELIUS

A1 Journal Article in PLANT JOURNAL

Sensing of viral infection and activation of innate immunity by toll-like receptor 3

Elisabeth VercammenJens StaalRudi Beyaert

A1 Journal Article in CLINICAL MICROBIOLOGY REVIEWS

T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappa B inhibitor A20

Beatrice CoornaertM BAENSKaren HeyninckTine BekaertMira HaegmanJens StaalLJ SUNZJJ CHENP MARYNENRudi Beyaert

A1 Journal Article in NATURE IMMUNOLOGY

2007

ABA is required for Leptosphaeria maculans resistance via ABI1- and ABI4-dependent signaling

Maria KaliffJens StaalMattias MyrenåsChristina Dixelius

A1 Journal Article in MOLECULAR PLANT-MICROBE INTERACTIONS

Defence components in Arabidopsis against Leptosphaeria maculans

Jens StaalMaria KaliffMattias PerssonChristina Dixelius

Tracing the ancient origins of plant innate immunity

Jens StaalC DIXELIUS

A1 Journal Article in TRENDS IN PLANT SCIENCE

2006

Early responses in the Arabidopsis-verticillium longisporum pathosystem are dependent on NDR1, JA- and ET-associated signals via cytosolic NPR1 and RFO1

Anna JohanssonJens StaalChristina Dixelius

A1 Journal Article in MOLECULAR PLANT-MICROBE INTERACTIONS

Genes and mechanisms in Arabidopsis innate immunity against Leptosphaeria maculans

Jens StaalChristina Dixelius

Liten kusin från labbet räddar rapsen från röta

Transgressive segregation reveals two Arabidopsis TIR-NB-LRR resistance genes effective against Leptosphaeria maculans, causal agent of blackleg disease

Jens StaalMaria KaliffSvante BohmanChristina Dixelius

A1 Journal Article in PLANT JOURNAL

2004

Characterisation of an Arabidopsis-Leptosphaeria maculans pathosystem : resistance partially requires camalexin biosynthesis and is independent of salicylic acid, ethylene and jasmonic acid signalling

Svante BohmanJens StaalBart P. H. J. ThommaMaolin WangChristina Dixelius

A1 Journal Article in PLANT JOURNAL