Research Explorer

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Researcher

Jeffrey Aalders

Publications & Research Data

Awards & Distinctions

37 Results

2026

Decoding Marfan syndrome cardiomyopathy using an advanced stem cell-derived heart model

Emiel Van WetterJeffrey AaldersLaura Muiño MosqueraJulie De BackerJolanda van Hengel

2025

Decoding Marfan syndrome cardiomyopathy using an advanced stem cell-derived heart model

Emiel Van WetterJeffrey AaldersLaura Muiño MosqueraJulie De BackerJolanda van Hengel

Exploring aneuploidies in two-center isolated bovine embryonic stem cell lines : implications for cultured meat production

Chloë DeelkensElly De VlieghereMario Van PouckeMasaki KinoshitaJeffrey AaldersLieven ThorrezBert DevriendtAnn Van SoomLuc PeelmanBjörn Menten et al.

A2 Journal Article in FUTURE FOODS

Human stem cell models for Marfan syndrome : a brief overview of the rising star in disease modelling

Jeffrey AaldersLaura Muiño MosqueraJolanda van Hengel

A1 Journal Article in FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

Oxygen handling practices for in vitro human pluripotent stem cell cardiomyocyte differentiation : a scoping literature review

Lisse FransJeffrey AaldersJolanda van HengelAlain J Labro

A1 Journal Article in STEM CELL REVIEWS AND REPORTS

2024

Combinatorial effects of surface plasma-treating and aligning PCL/chitosan nanofibers on the behavior of stem cell-derived cardiomyocytes for cardiac tissue engineering

Laurens LégerSheida AliakbarshiraziPegah ZahedifarJeffrey AaldersPascal Van Der VoortNathalie De GeyterRino MorentJolanda van HengelRouba Ghobeira

A1 Journal Article in APPLIED SURFACE SCIENCE

Generation of a human induced pluripotent stem cell line UGENTi002-A from an arrhythmogenic cardiomyopathy patient carrying the c.817C>T DSP heterozygous variant and isogenic control using CRISPR/Cas9 editing

Laurens LégerJeffrey AaldersNina HeymansKiara Van Acker-VerbercktLéa De BleeckerePaul CouckeBjörn MentenBarbara BauceLibero VitielloAlessandra Rampazzo et al.

A1 Journal Article in STEM CELL RESEARCH

Improving cardiac differentiation of human pluripotent stem cells by targeting ferroptosis

Jeffrey AaldersLaurens LégerBehrouz HassanniaVera GoossensTom Vanden BergheJolanda van Hengel

A1 Journal Article in REGENERATIVE THERAPY

Photoporation-mediated spatial intracellular delivery of stem cell-derived cardiomyocytes

Laurens LégerChloë De ClercqJeffrey AaldersKiara Van Acker-VerbercktKevin BraeckmansJolanda van Hengel

A2 Journal Article in METHODSX

Three-dimensional co-culturing of stem cell-derived cardiomyocytes and cardiac fibroblasts reveals a role for both cell types in Marfan-related cardiomyopathy

Jeffrey AaldersLaurens LégerLouis Van der MeerenSanjay SinhaAndre SkirtachJulie De BackerJolanda van Hengel

A1 Journal Article in MATRIX BIOLOGY

2023

Generation of human induced pluripotent stem cell line UGENTi001-A from a patient with Marfan syndrome carrying a heterozygous c.7754 T > C variant in FBN1 and the isogenic control UGENT001-A-1 using CRISPR/Cas9 editing

Jeffrey AaldersLaurens LégerAnthony DemolderLaura Muiño MosqueraPaul CouckeBjörn MentenJulie De BackerJolanda van Hengel

A1 Journal Article in STEM CELL RESEARCH

Modelling Marfan-related cardiomyopathy in vitro using human induced pluripotent stem cells

Jeffrey AaldersJolanda van HengelJulie De Backer

2022

Dielectric barrier discharge-treated aligned electrospun chitosan/polycaprolactone nanofibers for cardiac tissue engineering

Laurens LégerSheida AliakbarshiraziPegah ZahedifarNathalie De GeyterJeffrey AaldersRino MorentJolanda van HengelRouba Ghobeira

In vitro modelling of Marfan-related cardiomyopathy points to abnormalities in mechanobiology of the heart muscle cells

Jeffrey AaldersLaurens LégerLouis Van der MeerenPatrick SipsLaura Muiño MosqueraAndre SkirtachSanjay SinhaJulie De BackerJolanda van Hengel

In vitro modelling of Marfan-related cardiomyopathy points to abnormalities in mechanobiology of the heart muscle cells

Jeffrey AaldersLaurens LégerLouis Van der MeerenPatrick SipsLaura Muiño MosqueraAndre SkirtachSanjay SinhaJulie De BackerJolanda van Hengel

2021

Effects of fibrillin mutations on the behaviour of heart muscle cells in Marfan syndrome

Jeffrey AaldersLaurens LégerLouis Van der MeerenNatasja Van den VrekenAndre SkirtachSanjay SinhaJulie De BackerJolanda van Hengel

In vitro modelling of Marfan related cardiomyopathy points to abnormalities in mechanobiology of the heart muscle cells

Jeffrey AaldersLaurens LégerLouis Van der MeerenNatasja Van den VrekenAndre SkirtachSanjay SinhaJulie De BackerJolanda van Hengel

Liquid marbles : a cost-effective platform to generate cardiospheres from co-cultured cardiomyocytes and cardiac fibroblast for disease modelling

Jeffrey AaldersLaurens LégerSergio LeddaJolanda van Hengel

Photothermal nanofibres enable safe engineering of therapeutic cells

Ranhua XiongDawei HuaJelter Van HoeckDominika BerdeckaLaurens LégerStijn De MunterJuan FraireLaurens RaesAranit HarizajFélix Sauvage et al.

A1 Journal Article in NATURE NANOTECHNOLOGY

Use of transparent liquid marble : microbioreactor to culture cardiospheres

Jeffrey AaldersLaurens LégerDavide PirasJolanda van HengelSergio Ledda

Bookchapter in Next generation culture platforms for reliable in vitro models

2020

Effects of fibrillin mutations on the behavior of heart muscle cells in Marfan syndrome

Jeffrey AaldersLaurens LégerLouis Van der MeerenNatasja Van den VrekenAndre SkirtachSanjay SinhaJulie De BackerJolanda van Hengel

A1 Journal Article in SCIENTIFIC REPORTS

Liquid marble technology to create cost-effective 3D cardiospheres as a platform for in vitro drug testing and disease modelling

Jeffrey AaldersLaurens LégerTim TuerlingsSergio LeddaJolanda van Hengel

A2 Journal Article in METHODSX

2019

Cell communication in cardiac muscle cells

Jolanda van HengelJeffrey AaldersNatasja Van den VrekenMarleen De GrooteBieke Vanslembrouck

In vitro characterization of stem cell derived Marfan syndrome cardiomyocytes

Jeffrey AaldersLaurens LégerNatasja Van den VrekenSanjay SinhaJulie De BackerJolanda van Hengel

In vitro modelling of Marfan syndrome using stem cell derived cardiomyocytes

Jeffrey AaldersLaurens LégerNatasja Van den VrekenJulie De BackerJolanda van Hengel

Modelling Marfan syndrome in vitro using human stem cell derived cardiomyocytes and fibroblasts

Jeffrey AaldersLaurens LégerNatasja Van den VrekenJulie De BackerJolanda van Hengel

Robust protocol for feeder-free adaptation of cryopreserved human pluripotent stem cells

Jeffrey AaldersNatasja Van den VrekenMina PopovicSwati MishraBjörn HeindryckxJolanda van Hengel

A1 Journal Article in IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

2018

Functional measurements of stem cell derived cardiomyocytes to model Marfan syndrome in vitro

Jeffrey AaldersNatasja Van den VrekenFelipe SerranoSanjay SinhaJulie De BackerJolanda van Hengel

Interactions between stem cell derived cardiomyocytes and extra cellular matrix to model Marfan syndrome in vitro

Jeffrey AaldersNatasja Van den VrekenJulie De BackerJolanda van Hengel

Robust protocol for feeder-free adaptation of frozen pluripotent stem cells using StemFlex

Jeffrey AaldersNatasja Van den VrekenBjörn HeindryckxJolanda van Hengel

Stem cell derived cardiomyocytes extra cellular matrix to model Marfan syndrome in vitro

Jeffrey AaldersNatasja Van den VrekenJulie De BackerJolanda van Hengel

Stem cell derived cardiomyocytes to model Marfan syndrome in vitro

Jeffrey AaldersNatasja Van den VrekenJulie De BackerJolanda van Hengel

2017

From pluripotent stem cells to cardiomyocytes

Jeffrey AaldersNatasja Van den VrekenJolanda van Hengel

Maturation of human pluripotent stem cell-derived cardiomyocytes

Jolanda van HengelNatasja Van den VrekenJeffrey Aalders

2016

Assessing teratogenicity from the clustering of abnormal phenotypes in individual zebrafish larvae

Jeffrey AaldersShaukat AliTom J de JongMichael K Richardson

A1 Journal Article in ZEBRAFISH

Fungal bioreceptivity of Japanese tissue papers treated with plant dyes, watercolours, and acrylic paints in paper conservation

Somayeh SoleymaniJeffrey AaldersMichelle E GahanTracy IrelandDennis McNevin

A1 Journal Article in STUDIES IN CONSERVATION

2014

Teratological effects of a panel of sixty water-soluble toxicants on zebrafish development

Shaukat AliJeffrey AaldersMichael K Richardson

A1 Journal Article in ZEBRAFISH