Research Explorer

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Researcher

Jean-Christophe Marine

Awards & Distinctions

49 Results

2022

The long non-coding RNA SAMMSON is essential for uveal melanoma cell survival (Sept, 10.1038/s41388-021-02006-x, 2021)

Shanna DewaeleLouis DelhayeBoel De PaepeEric James de BonyJilke De WildeKatrien VanderheydenJasper AnckaertNurten YigitJustine NuytensEveline Vanden Eynde et al.

2014

Loss of autocrine endothelial-derived VEGF significantly reduces hemangiosarcoma development in conditional p53-deficient mice

Morvarid Farhang GhahremaniEnrico RadaelliKatharina HaighSona BartunkovaLieven HaenebalckeJean-Christophe MarineSteven GoossensJody Haigh

A1 Journal Article in CELL CYCLE

2013

p53 promotes VEGF expression and angiogenesis in the absence of an intact p21-Rb pathway

Morvarid Farhang GhahremaniSteven GoossensD NittnerX BisteauSona BartunkovaA ZwolinskaPaco HulpiauKatharina HaighLieven HaenebalckeBenjamin Drogat et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2012

MDMX is a key therapeutic target in skin melanoma

Agnieszka GembarskaJean-Christophe Marine

Molecular and genetic interplay between p53 and VEGF in tumour angiogenesis

Morvarid Farhang GhahremaniJody HaighJean-Christophe Marine

Role of the microRNA pathway in retinoblastoma

David NittnerJean-Christophe Marine

Suppression of Myc oncogenic activity by nucleostemin haploinsufficiency

Aleksandra ZwolinskaA Heagle WhitingChantal BeekmanJM SedivyJean-Christophe Marine

A1 Journal Article in ONCOGENE

2011

Cop1 constitutively regulates c-Jun protein stability and functions as a tumor suppressor in mice

Domenico MiglioriniSven BogaertsDieter DefeverRajesh VyasGeertrui DeneckerEnrico RadaelliAleksandra ZwolinskaVanessa DepaepeTino HochepiedWilliam C Skarnes et al.

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

Functional analysis of the p53 pathway in neuroblastoma cells using the small-molecule MDM2 antagonist Nutlin-3

Tom Van MaerkenAli RihaniDaniel DreidaxSarah De ClercqNurten YigitJean-Christophe MarineFrank WestermannAnne De PaepeJo VandesompeleFranki Speleman

A1 Journal Article in MOLECULAR CANCER THERAPEUTICS

MicroRNA control of cancer development

Irina LambertzJean-Christophe Marine

Study of three putative nuclear modulators of the p53 pathway

Aleksandra ZwolinskaJean-Christophe Marine

2010

An illegitimate microRNA target site within the 3' UTR of MDM4 affects ovarian cancer progression and chemosensitivity

Jessica WynendaeleAnja BöhnkeEleonora LeucciSøren Jensby NielsenIrina LambertzStefanie HammerNadja SbrzesnyDana KubitzaAnja WolfElise Gradhand et al.

A1 Journal Article in CANCER RESEARCH

An integrative genomics screen uncovers ncRNA T-UCR functions in neuroblastoma tumours

Pieter MestdaghE FredlundFilip PattynAli RihaniTom Van MaerkenJoëlle VermeulenCandy KumpsBjörn MentenKatleen De PreterA Schramm et al.

A1 Journal Article in ONCOGENE

Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death

Panagiota A SotiropoulouAurelie CandiGuilhem MascreSarah De ClercqKhalil Kass YoussefGaelle LapougeEllen DahlClaudio SemeraroGeertrui DeneckerJean-Christophe Marine et al.

A1 Journal Article in NATURE CELL BIOLOGY

Mdm2-mediated ubiquitylation: p53 and beyond

Jean-Christophe MarineG Lozano

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Monoallelic but not biallelic loss of Dicer1 promotes tumorigenesis in vivo

Irina LambertzDavid NittnerPieter MestdaghGeertrui DeneckerJo VandesompeleMA DyerJean-Christophe Marine

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Study of the physiological and oncogenic properties of Mdm2 and Mdm4

Sarah De ClercqJean-Christophe Marine

Widespread overexpression of epitope-tagged Mdm4 does not accelerate tumor formation in vivo

Sarah De ClercqAgniezska GembarskaGeertrui DeneckerMarion MaetensMichaël NaessensKatharina HaighJody HaighJean-Christophe Marine

A1 Journal Article in MOLECULAR AND CELLULAR BIOLOGY

p53 stabilization: the importance of nuclear import

Jean-Christophe Marine

Editorial material

2009

Antitumor Activity of the Selective MDM2 Antagonist Nutlin-3 Against Chemoresistant Neuroblastoma With Wild-Type p53

Tom Van MaerkenLiesbeth FerdinandeJasmien TaildemanIrina LambertzNurten YigitLiesbeth VercruysseAli RihaniMartin MichaelisJindrich CinatlClaude Cuvelier et al.

A1 Journal Article in JOURNAL OF THE NATIONAL CANCER INSTITUTE

Efficient mouse transgenesis using Gateway-compatible ROSA26 locus targeting vectors and F1 hybrid ES cells

Omar NyabiMichaël NaessensKatharina HaighAgnieszka GembarskaSteven GoossensMarion MaetensSarah De ClercqBenjamin DrogatLieven HaenebalckeSona Bartunkova et al.

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes

L GalluzziSA AaronsonJ AbramsES AlnemriDW AndrewsEH BaehreckeNG BazanMV BlagosklonnyK BlomgrenC Borner et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Transforming growth factor-beta and mutant p53 conspire to induce metastasis by antagonizing p63: a (ternary) complex affair

Jean-Christophe MarineGeert Berx

A1 Journal Article in BREAST CANCER RESEARCH

c-Abl Phosphorylates Hdmx and Regulates Its Interaction with p53

Valentina ZuckermanKristiaan LenosGrzegorz M. PopowiczIsabelle SilbermanTamar GrossmanJean-Christophe MarineTad A. HolakAart G. JochemsenYgal Haupt

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2008

Exosome secretion, including the DNA damage-induced p53-dependent secretory pathway, is severely compromised in TSAP6/Steap3-null mice

A LESPAGNOLD DUFLAUTChantal BeekmanL BLANCG FIUCCIJean-Christophe MarineM VIDALR AMSONA TELERMAN

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Real-time qPCR as a tool for evaluating RNAi-mediated gene silencing

Tom Van MaerkenPieter MestdaghSarah De ClercqFilip PattynNurten YigitAnne De PaepeJean-Christophe MarineFranki SpelemanJo Vandesompele

A2 Journal Article in Bioradiations

Regulation of SIRT6 protein levels by nutrient availability

Y KANFIR SHALMANV PESHTISN PILOSOFYM GOZLANKJ PEARSONB LERRERD MOAZEDJean-Christophe MarineR DE CABO et al.

A1 Journal Article in FEBS LETTERS

TCTP protects from apoptotic cell death by antagonizing bax function

L SUSINIS BESSED DUFLAUTA LESPAGNOLChantal BeekmanG FIUCCIAR ATKINSOND BUSSOP POUSSINJean-Christophe Marine et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2007

A critical role for p53 in the control of NF-kappa B-dependent gene expression in TLR4-stimulated dendritic cells exposed to genistein

Nathalie DijsselbloemS GORIELYV ALBARANISarah GerloSarah FrancozJean-Christophe MarineM GOLDMANGuy HaegemanWim Vanden Berghe

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Distinct roles of Mdm2 and Mdm4 in red cell production

Marion MaetensGilles DoumontSarah De ClercqSarah FrancozP FROMENTE BELLEFROIDU KLINGMULLERG LOZANOJean-Christophe Marine

A1 Journal Article in BLOOD

MDMX: from bench to bedside

Jean-Christophe MarineMA DYERAG JOCHEMSEN

A1 Journal Article in JOURNAL OF CELL SCIENCE

The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells

AP BRACKEND KLEINE-KOHLBRECHERN DIETRICHD PASINIG GARGIULOChantal BeekmanK THEILGAARD-MONCHS MINUCCIBT PORSEJean-Christophe Marine et al.

A1 Journal Article in GENES & DEVELOPMENT

2006

Evi1 is specifically expressed in the distal tubule and duct of the Xenopus pronephros and plays a role in its formation

C VAN CAMPENHOUTM NICHANEA ANTONIOUH PENDEVILLEOJ BRONCHAINJean-Christophe MarineA MAZABRAUDML VOZEJ BELLEFROID

A1 Journal Article in DEVELOPMENTAL BIOLOGY

Evolutionarily conserved role of nucleostemin: Controlling proliferation of stem/progenitor cells during early vertebrate development

Chantal BeekmanM NICHANESarah De ClercqMarion MaetensT FLOSSW WURSTE BELLEFROIDJean-Christophe Marine

A1 Journal Article in MOLECULAR AND CELLULAR BIOLOGY

Inactivation of the p53 pathway in retinoblastoma

NA LAURIESL DONOVANCS SHIHJK ZHANGN MILLSC FULLERA TEUNISSES LAMY RAMOSA MOHAN et al.

A1 Journal Article in NATURE

Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4

Jean-Christophe MarineSarah FrancozMarion MaetensG WAHLF TOLEDOG LOZANO

Editorial material

Mdm2, but not Mdm4, protects terminally differentiated smooth muscle cells from p53-mediated caspase-3-independent cell death

LSM BOESTENSM ZADELAARSarah De ClercqSarah FrancozA VAN NIEUWKOOPEAL BIESSENF HOFMANNS FEILR FEILAG JOCHEMSEN et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo

Sarah FrancozPascal FromentSven BogaertsSarah De ClercqMarion MaetensGilles DoumontE BELLEFROIDJean-Christophe Marine

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small-molecule MDM2 antagonists as a new therapy concept for neuroblastoma

Tom Van MaerkenFranki SpelemanJ VERMEULENIrina LambertzSarah De ClercqEls De SmetNurten YigitV COPPENSJan PhilippéAnne De Paepe et al.

A1 Journal Article in CANCER RESEARCH

2005

DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation

Koji OkamotoKenji KashimaYaron PeregMichiko IshidaSatomi YamazakiAyumi NotaAmina TeunisseDomenico MiglioriniIssay KitabayashiJean-Christophe Marine et al.

A1 Journal Article in MOLECULAR AND CELLULAR BIOLOGY

G1 checkpoint failure and increased tumor susceptibility in mice lacking the novel p53 target Ptprv

Gilles DoumontA MARTORIATIChantal BeekmanSven BogaertsPJ MEEF BUREAUE COLOMBOM ALCALAYE BELLEFROIDF MARCHESI et al.

A1 Journal Article in EMBO JOURNAL

Mdmx as an essential regulator of p53 activity

Jean-Christophe MarineAG JOCHEMSEN

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nucleophosmin is required for DNA integrity and p19(Arf) protein stability

E COLOMBOP BONETTIEL DENCHIP MARTINELLIR ZAMPONIJean-Christophe MarineK HELINB FALINIPG PELICCI

A1 Journal Article in MOLECULAR AND CELLULAR BIOLOGY

PTPRV is a key mediator of p53-induced cell cycle exit

Gilles DoumontA MARTORIATIJean-Christophe Marine

A1 Journal Article in CELL CYCLE

dapk1, encoding an activator of a p19(ARF)-p53-mediated apoptotic checkpoint, is a transcription target of p53

A MARTORIATIG DOUMONTM ALCALAYE BELLEFROIDPG PELICCIJean-Christophe Marine

A1 Journal Article in ONCOGENE

2004

Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity

D DANOVIE MEULMEESTERD PASINID MIGLIORINIM CAPRAR FRENKP DE GRAAFSarah FrancozP GASPARINIA GOBBI et al.

A1 Journal Article in MOLECULAR AND CELLULAR BIOLOGY

Direct regulation of the Nrarp gene promoter by the notch signaling pathway

P PIROTLA VAN GRUNSVENJean-Christophe MarineD HUYLEBROECKEJ BELLEFROID

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

GSK3-Mediated BCL-3 phosphorylation modulates its degradation and its oncogenicity

P VIATOURE DEJARDINM WARNIERF LAIRE CLAUDIOF BUREAUJean-Christophe MarineMP MERVILLEU MAURERD GREEN et al.

A1 Journal Article in MOLECULAR CELL

Mdmx and Mdm2 - Brothers in arms?

Jean-Christophe MarineAG JOCHEMSEN

A1 Journal Article in CELL CYCLE