Research Explorer

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Researcher

Jan Willem Bek

Awards & Distinctions

28 Results

2024

Bmpr1aa modulates the severity of the skeletal phenotype in an fkbp10-deficient Bruck syndrome zebrafish model

Tamara JaraysehSophie DebaenstHanna De SaffelToon RosseelMauro Alessio MilazzoJan Willem BekDavid M HudsonFilip Van NieuwerburghYannick GansemansIván Josipovic et al.

A1 Journal Article in JOURNAL OF BONE AND MINERAL RESEARCH

Crispant analysis in zebrafish as a tool for rapid functional screening of disease-causing genes for bone fragility

Sophie DebaenstTamara JaraysehHanna De SaffelJan Willem BekMatthieu BooneIván JosipovicPierre KibleurRonald Y KwonPaul CouckeAndy Willaert

A2 Journal Article in ELIFE

MOXD1 is a lineage-specific gene and a tumor suppressor in neuroblastoma

Elina FredlundStina AnderssonElien HilgertEzequiel MonferrerGuadalupe Álvarez-HernánSinan KarakayaSiebe LoontiensJan Willem BekTomas GregorEstelle Lecomte et al.

A1 Journal Article in SCIENCE ADVANCES

Zebrafish avatars : toward functional precision medicine in low-grade serous ovarian cancer

Charlotte FieuwsJan Willem BekBram PartonElyne De NeefOlivier De WeverMilena HoorneMarta F. EstradaJo Van DorpeHannelore DenysKoen Van de Vijver et al.

A1 Journal Article in CANCERS

2023

A tapt1 knock-out zebrafish line with aberrant lens development and impaired vision models human early-onset cataract

Tamara JaraysehBrecht GuillemynHanna De SaffelJan Willem BekDelfien SyxSofie SymoensYannick GansemansFilip Van NieuwerburghSujatha JagadeeshJayarekha Raja et al.

A1 Journal Article in HUMAN GENETICS

Crispant analysis in zebrafish as a tool for rapid functional screening of disease-causing genes for Osteogenesis Imperfecta

Sophie DebaenstHanna De SaffelJan Willem BekAdelbert De ClercqTamara JaraysehLauren SahdPaul CouckeAndy Willaert

Molecular characterization of SOX11 as multifaceted epigenetic regulator in neuroblastoma

Amber LouwagieFranki SpelemanKatleen De PreterJan Willem Bek

SOX11 is a mediator of core regulatory circuit robustness : upregulation of SWI/SNF components and recruitment of transcriptional enhancer NONO

Amber LouwagieBieke DecaestekerSarah-Lee BekaertFanny De VloedEllen SandersStéphane Van HaverTim PietersPieter Van VlierbergheS RobertsS Ek et al.

Syntaxin 18 defects in human and zebrafish unravel key roles in early cartilage and bone development

Brecht GuillemynHanna De SaffelJan Willem BekPiyanoot TapaneeyaphanAdelbert De ClercqTamara JaraysehSophie DebaenstAndy WillaertRiet De RyckePeter H. Byers et al.

A1 Journal Article in JOURNAL OF BONE AND MINERAL RESEARCH

Syntaxin-18 defects in human and zebrafish cause traffic jams and unravel key roles in early bone development

Brecht GuillemynHanna De SaffelJan Willem BekPiyanoot TapaneeyaphanAdelbert De ClercqTamara JaraysehSophie DebaenstAndy WillaertPeter ByersPaul Coucke et al.

2022

A tapt1 knockout zebrafish line with aberrant lens development and impaired vision models human pediatric cataract

Tamara JaraysehBrecht GuillemynHanna De SaffelJan Willem BekSujatha JagadeeshSofie SymoensFransiska MalfaitDelfien SyxFilip Van NieuwerburghYannick Gansemans et al.

A tapt1 knockout zebrafish line with aberrant lens development and impaired vision models human pediatric cataract

Tamara JaraysehBrecht GuillemynHanna De SaffelJan Willem BekSujatha JagadeeshSofie SymoensFransiska MalfaitDelfien SyxFilip Van NieuwerburghYannick Gansemans et al.

Crispant screening in zebrafish as a promising approach for rapid functional screening of osteoporosis candidate genes and known genes for Osteogenesis Imperfecta

Sophie DebaenstHanna De SaffelJan Willem BekAdelbert De ClercqTamara JaraysehLauren SahdPaul CouckeAndy Willaert

RRM2 enhances MYCN-driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition

Carolina de Carvalho NunesLisa DepestelLiselot MusKaylee M. KellerLouis DelhayeAmber LouwagieMuhammad RishfiAlex WhaleNeesha KaraSimon R. Andrews et al.

A1 Journal Article in SCIENCE ADVANCES

2021

Lrp5 mutant and crispant zebrafish faithfully model human osteoporosis, establishing the zebrafish as a platform for CRISPR‐based functional screening of osteoporosis candidate genes

Jan Willem BekChen ShochatAdelbert De ClercqHanna De SaffelAnnekatrien BoelJuriaan MetzFrans RodenburgDavid KarasikAndy WillaertPaul Coucke

A1 Journal Article in JOURNAL OF BONE AND MINERAL RESEARCH

Photoconvertible fluorescent proteins : a versatile tool in zebrafish skeletal imaging

Jan Willem BekAdelbert De ClercqHanna De SaffelMieke SoenensAnn HuysseunePaul Eckhard WittenPaul CouckeAndy Willaert

A1 Journal Article in JOURNAL OF FISH BIOLOGY

The ZE-Tunnel : an affordable, easy-to-assemble, and user-friendly benchtop zebrafish swim tunnel

Jan Willem BekAdelbert De ClercqPaul CouckeAndy Willaert

A1 Journal Article in ZEBRAFISH

The zebrafish in biomedical research : a vertebrate model to study skeletal disorders

Jan Willem BekPaul CouckeAndy Willaert

2020

Zebrafish : a resourceful vertebrate model to investigate skeletal disorders

Francesca TonelliJan Willem BekRoberta BesioAdelbert De ClercqLaura LeoniPhil SalmonPaul CouckeAndy WillaertAntonella Forlino

A1 Journal Article in FRONTIERS IN ENDOCRINOLOGY

b3galt6 Knock-out zebrafish recapitulate β3GalT6-deficiency disorders in human and reveal a trisaccharide proteoglycan linkage region

Sarah DelbaereAdelbert De ClercqShuji MizumotoFredrik NobornJan Willem BekLien AlluynCharlotte GistelinckDelfien SyxPhil L. SalmonPaul Coucke et al.

A1 Journal Article in FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

b3galt6 knock-out zebrafish recapitulate β3GalT6-deficiency disorders in human and reveal a trisaccharide proteoglycan linkage region

Sarah DelbaereAdelbert De ClercqShuji MizumotoFredrik NobornJan Willem BekLien AlluynCharlotte GistelinckDelfien SyxPhil L. SalmonPaul Coucke et al.

2019

Beyond the whole-mount phenotype : high-resolution imaging in fluorescence-based applications on zebrafish

Veronika OralovaJoana Teixeira RosaMieke SoenensJan Willem BekAndy WillaertPaul Eckhard WittenAnn Huysseune

A1 Journal Article in BIOLOGY OPEN

In-depth characterization of the ultrastructural variability of the vertebral column in a severe, medium and mildly affected Osteogenesis Imperfecta zebrafish model

Adelbert De ClercqHanna De SaffelJan Willem BekMyriam ClaeysPetra VermassenPaul CouckeAndy Willaert

The zebrafish as a model for fragile bone disorders

Jan Willem BekHanna De SaffelOsama EssawiAdelbert De ClercqPaul Eckhard WittenAnn HuysseuneJuriaan MetzPhil SalmonPaul CouckeAndy Willaert

The zebrafish as a model for recessive types of Osteogenesis Imperfecta.

Jan Willem BekHanna De SaffelOsama EssawiAdelbert De ClercqPaul Eckhard WittenAnn HuysseunePhil SalmonPaul CouckeAndy Willaert

The zebrafish as a model for recessive types of osteogenesis imperfecta

Jan Willem BekHanna De SaffelOsama EssawiAdelbert De ClercqPaul Eckhard WittenAnn HuysseunePhil SalmonPaul CouckeAndy Willaert

2018

Screening for osteogenic compounds using the zebrafish as a model

Jan Willem BekCharlotte GistelinckHanna De SaffelPaul CouckeAndy Willaert

Zebrafish type I collagen mutants faithfully recapitulate human type I collagenopathies

Charlotte GistelinckRonald Y KwonFransiska MalfaitSofie SymoensMatthew P HarrisKatrin HenkeMichael B HawkinsShannon FisherPatrick SipsBrecht Guillemyn et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA