Research Explorer

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Researcher

Jan Van Bocxlaer

Awards & Distinctions

232 Results

2025

Dose-limiting toxicities of paclitaxel in breast cancer patients : studying interactions between pharmacokinetics, physical activity, and body composition : a protocol for an observational cohort study

Len De NysAnita Barzegar-FallahKatrien LanckmansStephane SteurbautDavid BeckwéeAmy de Haar-HollemanSteven ProvynElke GasthuysSofie Vande CasteelePieter-Jan De Sutter et al.

A1 Journal Article in CANCERS

2024

Development and validation of an UPLC-MS/MS method for the determination of irinotecan (CPT-11), SN-38 and SN-38 glucuronide in human plasma and peritoneal tumor tissue from patients with peritoneal carcinomatosis

Elke GasthuysJudith van OvostSofie Vande CasteeleSarah CosynsWim CeelenJan Van BocxlaerAn Vermeulen

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Exploring the impact of efavirenz on aflatoxin B1 metabolism : insights from a physiologically based pharmacokinetic model and a human liver microsome study

Orphélie LootensMarthe De BoevreElke GasthuysSarah De SaegerJan Van BocxlaerAn Vermeulen

A1 Journal Article in TOXINS

Penetration of antibiotics into subcutaneous and intramuscular interstitial fluid : a meta-analysis of microdialysis studies in adults

Pieter-Jan De SutterEline HermansPieter De CockJan Van BocxlaerElke GasthuysAn Vermeulen

A1 Journal Article in CLINICAL PHARMACOKINETICS

Population pharmacokinetics of lisinopril in hypertensive children and adolescents with normal to mildly reduced kidney function

Louis SandraEva DegraeuwePauline De BruyneSiegrid De BaereSiska CroubelsJan Van BocxlaerAnn RaesJohan Vande WalleElke GasthuysAn Vermeulen

A1 Journal Article in BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Reliability of physiologically based pharmacokinetic models for the prediction of drug distribution and tissue concentrations

Pieter-Jan De SutterAn VermeulenJan Van Bocxlaer

Unlocking diversity : towards a comprehensive framework for physiologically based pharmacokinetic population qualification in Sub Saharan Africa

Orphélie LootensMarthe De BoevreElke GasthuysJan Van BocxlaerSarah De SaegerAn Vermeulen

2023

Building a human physiologically based pharmacokinetic model for aflatoxin B1 to simulate interactions with drugs

Orphélie LootensMarthe De BoevreJia NingElke GasthuysJan Van BocxlaerSarah De SaegerAn Vermeulen

A1 Journal Article in PHARMACEUTICS

Building a physiologically based pharmacokinetic model for a carcinogenic food contaminant

Orphélie LootensMarthe De BoevreJia NingElke GasthuysJan Van BocxlaerSarah De SaegerAn Vermeulen

Building a physiologically based pharmacokinetic model for a carcinogenic food contaminant

Orphélie LootensMarthe De BoevreAn VermeulenJia NingElke GasthuysJan Van BocxlaerSarah De Saeger

Building a physiologically-based pharmacokinetic model for a carcinogenic food contaminant aflatoxin B1

Orphélie LootensMarthe De BoevreJia NingElke GasthuysJan Van BocxlaerSarah De SaegerAn Vermeulen

2022

Altered intravenous drug disposition in people living with cystic fibrosis : a meta‐analysis integrating top‐down and bottom‐up data

Pieter-Jan De SutterMaxime Van HaeverbekeEva Van BraeckelStephanie Van BiervlietJan Van BocxlaerAn VermeulenElke Gasthuys

A1 Journal Article in CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY

Determination of pharmacokinetic parameters of efavirenz an aflatoxin B1 : an approach to unravel possible interactions

Orphélie LootensAn VermeulenElke GasthuysJan Van BocxlaerSarah De SaegerMarthe De Boevre

Determination of pharmacokinetic parameters of efavirenz and aflatoxin B1 : an approach to unravel possible interactions

Orphélie LootensAn VermeulenElke GasthuysJan Van BocxlaerSarah De SaegerMarthe De Boevre

High throughput analytical report writing in R : a case study of validating an LC-MS method for the quantification of amoxicillin in human plasma

Pieter-Jan De SutterElke GasthuysAn VermeulenJan Van Bocxlaer

Possible mechanisms of the interplay between drugs and mycotoxins : is there a possible impact?

Orphélie LootensAn VermeulenSiska CroubelsSarah De SaegerJan Van BocxlaerMarthe De Boevre

A1 Journal Article in TOXINS

Unravelling the pharmacokinetics of aflatoxin B1 : in vitro determination of Michaelis-Menten constants, intrinsic clearance and the metabolic contribution of CYP1A2 and CYP3A4 in pooled human liver microsomes

Orphélie LootensMarthe De BoevreElke GasthuysJan Van BocxlaerAn VermeulenSarah De Saeger

A1 Journal Article in FRONTIERS IN MICROBIOLOGY

2021

Determination of pharmacokinetic parameters of efavirenz and aflatoxin B1 : an approach to unravel possible interactions

Orphélie LootensAn VermeulenJan Van BocxlaerSarah De SaegerMarthe De Boevre

Linking in vitro intrinsic dissolution rate and thermodynamic solubility with pharmacokinetic profiles of bedaquiline long-acting aqueous microsuspensions in rats

Thi Thanh Vy NguyenJan BevernageNicolas DarvilleChristophe TistaertJan Van BocxlaerStefaan RossenuAn Vermeulen

A1 Journal Article in MOLECULAR PHARMACEUTICS

Mycotoxin-drug interactions at the level of CYP450 enzymes

Orphélie LootensSarah De SaegerMarthe De BoevreAn VermeulenJan Van Bocxlaer

Physiologically based pharmacokinetic modelling of lisinopril in children: A case story of angiotensin converting enzyme inhibitors

Feifan XieJan Van BocxlaerAn Vermeulen

A1 Journal Article in BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

2020

An integrated paediatric population PK/PD analysis of dDAVP : how do PK differences translate to clinical outcomes?

Robin MicheletLien DosscheCharlotte Van HerzeelePauline De BruyneElke GasthuysJan Van BocxlaerJohan Vande WalleAn Vermeulen

A1 Journal Article in CLINICAL PHARMACOKINETICS

Establishment and characterization of a cell line and patient-derived xenograft (PDX) from peritoneal metastasis of low-grade serous ovarian carcinoma

Elien De ThayeKoen Van de VijverJoni Van der MeulenJoachim TaminauGlenn WagemansHannelore DenysJo Van DorpeGeert BerxWim CeelenJan Van Bocxlaer et al.

A1 Journal Article in SCIENTIFIC REPORTS

Exploration of more personalized treatments in ovarian cancer using a pharmacodynamic protein biomarker and patient-derived xenograft technology

Elien De ThayeJan Van BocxlaerAn VermeulenPieter Colin

PKPD modeling and dosing considerations in advanced ovarian cancer patients treated with cisplatin-based intraoperative intraperitoneal chemotherapy

Feifan XieJan Van BocxlaerPieter ColinCharlotte CarlierOlivier Van KerschaverJoseph WeertsHannelore DenysPhilippe TummersWouter WillaertWim Ceelen et al.

A1 Journal Article in AAPS JOURNAL

Pediatric pharmacology of desmopressin in children with enuresis : a comprehensive review

Elke GasthuysLien DosscheRobin MicheletJens Peter NorgaardMathias DevreeseSiska CroubelsAn VermeulenJan Van BocxlaerJohan Vande Walle

A1 Journal Article in PEDIATRIC DRUGS

Pharmacokinetics in patients with cystic fibrosis : a systematic review of data published between 1999 and 2019

Pieter-Jan De SutterElke GasthuysEva Van BraeckelPetra SchelstraeteStephanie Van BiervlietJan Van BocxlaerAn Vermeulen

A1 Journal Article in CLINICAL PHARMACOKINETICS

Target-controlled infusion of cefepime in critically Ill patients

Stijn JonckheereNikolaas De NeveJan VerbekeKoen De DeckerInger BrandtAn BoelJan Van BocxlaerMichel StruysPieter J. Colin

A1 Journal Article in ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

2019

Bioanalysis and model based treatment optimization for preclinical and clinical studies of peritoneal carcinomatosis from ovarian cancer

Feifan XieJan Van BocxlaerAn VermeulenPieter Colin

Characterization of porcine hepatic and intestinal drug metabolizing CYP450 : comparison with human orthologues from a quantitative, activity and selectivity perspective

Wim SchelstraeteLaura De ClerckElisabeth GovaertJoske MillecamMathias DevreeseDieter DeforceJan Van BocxlaerSiska Croubels

A1 Journal Article in SCIENTIFIC REPORTS

Model-based analysis of treatment effects of paclitaxel microspheres in a microscopic peritoneal carcinomatosis model in mice.

Feifan XieKaat De ClercqChris VervaetJan Van BocxlaerPieter ColinAn Vermeulen

A1 Journal Article in PHARMACEUTICAL RESEARCH

PBPK and its virtual populations : the impact of physiology on pediatric pharmacokinetic predictions of tramadol

Huybrecht T'jollynAn VermeulenJan Van Bocxlaer

A1 Journal Article in AAPS JOURNAL

Pharmacodynamic interaction of remifentanil and dexmedetomidine on depth of sedation and tolerance of laryngoscopy

Maud A. S. WeerinkClemens R. M. BarendsErnesto R. R. MuskietKoen M. E. M. ReyntjensFroukje H. KnotnerusMartine OostraJan Van BocxlaerMichel StruysPieter Colin

A1 Journal Article in ANESTHESIOLOGY

Pharmacokinetic evaluation of linezolid administered intravenously in obese patients with pneumonia

Feifan XieKonstantinos MantzarlisPolychronis MalliotakisVasileios KoulourasSophie DegrooteDespoina KoulentiStijn BlotKoen BousseryJan Van BocxlaerPieter Colin

A1 Journal Article in JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Switchability of gabapentin formulations : a randomized trial to assess bioequivalence between Neurontin and Gabasandoz on the individual subject level

Griet Van LanckerLucas Van BortelBrant DelafontaineKoen BousseryEleonora SwartAbdel ChahbouniJan Van BocxlaerPieter Colin

A1 Journal Article in CLINICAL PHARMACOLOGY & THERAPEUTICS

2018

A dried blood spot assay for paclitaxel and its metabolites

Feifan XieElien De ThayeAn VermeulenJan Van BocxlaerPieter Colin

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

A model-based analysis of the kinetics of leukocytes in stage III ovarian cancer patients treated with neo-adjuvant chemotherapy, cytoreductive surgery and cisplatin-based intraperitoneal chemoperfusion

Feifan XieCharlotte CarlierWim CeelenJan Van BocxlaerAn VermeulenPieter Colin

A physiologically based pharmacokinetic perspective on the clinical utility of albumin-based dose adjustments in critically ill patients

Huybrecht T'jollynAn VermeulenJan Van BocxlaerPieter Colin

A1 Journal Article in CLINICAL PHARMACOKINETICS

Claiming desmopressin therapeutic equivalence in children requires pediatric data : a population PKPD analysis

Robin MicheletLien DosscheCharlotte Van HerzeeleJan Van BocxlaerAn VermeulenJohan Vande Walle

A1 Journal Article in EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Maturation of hepatic cytochrome P450 enzymes in conventional pigs : fact or fiction?

Joske MillecamLaura De ClerckElisabeth GovaertMathias DevreeseElke GasthuysWim SchelstraeteDieter DeforceLies De BockJan Van BocxlaerStanislas Sys et al.

Maturation of hepatic cytochrome P450 enzymes in conventional pigs : the added value of proteomics

Joske MillecamLaura De ClerckElisabeth GovaertMathias DevreeseElke GasthuysWim SchelstraeteDieter DeforceLies De BockJan Van BocxlaerStanislas Sys et al.

Maturation of hepatic cytochrome P450 enzymes in conventional pigs as model for preclinical paediatric drug research

Joske MillecamLaura De ClerckElisabeth GovaertMathias DevreeseElke GasthuysWim SchelstraeteDieter DeforceLies De BockJan Van BocxlaerStanislas Sys et al.

Prediction of pediatric pharmacokinetics to optimize dose regimens using bottom-up, top-down and middle-out approaches

Robin MicheletAn VermeulenJan Van Bocxlaer

Results of a multicenter population pharmacokinetic study of ciprofloxacin in children with complicated urinary tract infection

Kevin MeestersRobin MicheletREINER MAUELAnn RaesJan Van BocxlaerJohan Vande WalleAn Vermeulen

A1 Journal Article in ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The ontogeny of cytochrome P450 enzyme activity and protein abundance in conventional pigs in support of preclinical pediatric drug research

Joske MillecamLaura De ClerckElisabeth GovaertMathias DevreeseElke GasthuysWim SchelstraeteDieter DeforceLies De BockJan Van BocxlaerStanislas Sys et al.

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

The use of PBPK modeling across the pediatric age range using propofol as a case

Robin MicheletJan Van BocxlaerKarel AllegaertAn Vermeulen

A1 Journal Article in JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

2017

A new approach in pediatric drug design : the development of a pediatric pig model, part II : the maturation of hepatic cytochrome P450 enzymes using enzyme activity and proteomics

Joske MillecamElke GasthuysMathias DevreeseDieter DeforceLies De BockJan Van BocxlaerSiska Croubels

Electrospray ionization mass spectrometry for the hydrolysis complexes of cisplatin : implications for the hydrolysis process of platinum complexes

Feifan XiePieter ColinJan Van Bocxlaer

A1 Journal Article in JOURNAL OF MASS SPECTROMETRY

PBPK in preterm and term neonates : a review

Robin MicheletJan Van BocxlaerAn Vermeulen

A1 Journal Article in CURRENT PHARMACEUTICAL DESIGN

Paediatric PBPK modelling of propofol using the middle out approach

Robin MicheletJan Van BocxlaerAn Vermeulen

Pharmacokinetic analysis of modified-release metoprolol formulations : an interspecies comparison

Elien De ThayeAnouk VervaeckEleonora MarosticaJean Paul RemonJan Van BocxlaerChris VervaetAn Vermeulen

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Strategies for determining correct cytochrome P450 contributions in hepatic clearance predictions : in vitro-in vivo extrapolation as modelling approach and tramadol as proof-of concept compound

Huybrecht T'jollynJan SnoeysJan Van BocxlaerLies De BockPieter AnnaertAchiel Van PeerKarel AllegaertGeert MannensAn VermeulenKoen Boussery

A1 Journal Article in EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

The ontogeny of hepatic cytochrome P450 enzymes in conventional pigs using enzyme activity and proteomics

Joske MillecamElke GasthuysMathias DevreeseDieter DeforceJan Van BocxlaerSiska Croubels

Zwitterionic hydrophilic interaction liquid chromatography-tandem mass spectrometry with HybridSPE-precipitation for the determination of intact cisplatin in human plasma

Feifan XiePieter ColinJan Van Bocxlaer

A1 Journal Article in TALANTA

2016

A model-based analysis of the predictive performance of different renal function markers for cefepime clearance in the ICU

Stijn JonckheereNikolaas De NeveHans De BeenhouwerMario BerthAn VermeulenJan Van BocxlaerPieter Colin

A1 Journal Article in JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Antimicrobial effect of a single dose of amoxicillin on the oral microbiota

Cecilia Larsson WexellHenrik RybergWivi-Anne Sjöberg AnderssonSusanne BlomqvistPieter ColinJan Van BocxlaerGunnar Dahlén

A1 Journal Article in CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH

Bioequivalence in adults does not mean bioequivalence in children

Lien DosscheRobin MicheletPauline De BruyneJan Van BocxlaerAn VermeulenJohan Vande Walle

Bioequivalence in adults is not always bioequivalence in children

Lien DosscheAnn RaesPauline De BruyneRobin MicheletAn VermeulenJan Van BocxlaerJohan Vande Walle

Characterizing hepatic clearance in early life : PBPK as modelling tool and tramadol as guide

Huybrecht T'jollynJan Van BocxlaerAn VermeulenKoen Boussery

Disulfiram inhibition of cyanide formation after acetonitrile poisoning

Peter De PaepePieter ColinPieter DepuydtAn-Sofie DecaveleJulie De SmetKoen BousseryChristophe StoveDominique BenoitAlain VerstraeteJan Van Bocxlaer et al.

A1 Journal Article in CLINICAL TOXICOLOGY

Drug administration via enteral feeding tube in residential care facilities for individuals with intellectual disability : a focus group study on guideline implementation

Elke JoosInge Van TongelenKaren WijnantsEls MehuysJan Van BocxlaerJean Paul RemonMaria GrypdonckMyriam Van WinckelKoen Boussery

A2 Journal Article in JOURNAL OF INTELLECTUAL DISABILITIES

Effect of food and pharmaceutical formulation on desmopressin pharmacokinetics in children

Robin MicheletLien DosschePauline De BruynePieter ColinKoen BousseryJohan Vande WalleJan Van BocxlaerAn Vermeulen

Effect of food and pharmaceutical formulation on desmopressin pharmacokinetics in children

Robin MicheletLien DosschePauline De BruynePieter ColinKoen BousseryJohan Vande WalleJan Van BocxlaerAn Vermeulen

Effects of food and pharmaceutical formulation on desmopressin pharmacokinetics in children

Robin MicheletLien DosschePauline De BruynePieter ColinKoen BousseryJohan Vande WalleJan Van BocxlaerAn Vermeulen

A1 Journal Article in CLINICAL PHARMACOKINETICS

Interaction between Fusarium mycotoxins and cytochrome P450 drug metabolizing enzymes/ABC drug transporters in a porcine animal model

Wim SchelstraeteMathias DevreeseJan Van BocxlaerSiska Croubels

Knowledge of staff members of residential care facilities for individuals with intellectual disability on medication administration via enteral feeding tube

Elke JoosEls MehuysJan Van BocxlaerJean Paul RemonMyriam Van WinckelKoen Boussery

A1 Journal Article in JOURNAL OF INTELLECTUAL DISABILITY RESEARCH

Medication administration via enteral feeding tube: a survey of pharmacists' knowledge

Elke JoosStacey VerbekeEls MehuysJan Van BocxlaerJean Paul RemonMyriam Van WinckelKoen Boussery

A1 Journal Article in INTERNATIONAL JOURNAL OF CLINICAL PHARMACY

PK/PD modelling of the QT interval : a step towards defining the translational relationship between in vitro, awake Beagle dogs, and humans

Eleonora MarosticaKarel Van AmmelArd TeismanDavid GallacherJan Van BocxlaerFilip De RidderKoen BousseryAn Vermeulen

A1 Journal Article in AAPS JOURNAL

What about confidence intervals? : a word of caution when interpreting PTA simulations

Pieter ColinDouglas J EleveldStijn JonckheereJan Van BocxlaerJan De WaeleAn Vermeulen

A1 Journal Article in JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

2015

Age-related differences in CYP3A abundance and activity in the liver of the Gottingen Minipig

Els Van PeerLies De BockKoen BousseryJan Van BocxlaerChristophe CasteleynChris Van GinnekenSteven Van Cruchten

A1 Journal Article in BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Degradable ketal-based block copolymer nanoparticles for anticancer drug delivery : a systematic evaluation

Benoit LouageQilu ZhangNane VanparijsLenny VoorhaarSofie Vande CasteeleYang ShiWim E HenninkJan Van BocxlaerRichard HoogenboomBruno De Geest

A1 Journal Article in BIOMACROMOLECULES

Drug administration via enteral feeding tubes in residential care facilities for individuals with intellectual disability : an observational study

Elke JoosEls MehuysJan Van BocxlaerJean Paul RemonMyriam Van WinckelKoen Boussery

A1 Journal Article in JOURNAL OF INTELLECTUAL DISABILITY RESEARCH

Hot-melt extrusion of polyvinyl alcohol for oral immediate release applications

Wesley De JaeghereThomas De BeerJan Van BocxlaerJean Paul RemonChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Modelling of drug-induced QT-interval prolongation: estimation approaches and translational opportunities

Eleonora MarosticaKarel Van AmmelArd TeismanKoen BousseryJan Van BocxlaerFilip De RidderDavid GallacherAn Vermeulen

A1 Journal Article in JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Physiologically based pharmacokinetic predictions of tramadol exposure throughout pediatric life: an analysis of the different clearance contributors with emphasis on CYP2D6 maturation

Huybrecht T'jollynJan SnoeysAn VermeulenRobin MicheletFilip CuykensGeert MannensAchiel Van PeerPieter AnnaertKarel AllegaertJan Van Bocxlaer et al.

A1 Journal Article in AAPS JOURNAL

Physiology-based IVIVE predictions of tramadol from in vitro metabolism data

Huybrecht T'jollynJan SnoeysPieter ColinJan Van BocxlaerPieter AnnaertFilip CuyckensAn VermeulenAchiel Van PeerKarel AllegaertGeert Mannens et al.

A1 Journal Article in PHARMACEUTICAL RESEARCH

The ontogeny of hepatic CYP3A, CYP2C and CYP2E enzyme activity in conventional pigs

Joske MillecamMathias DevreeseLies De BockJan Van BocxlaerElke GasthuysPatrick De BackerSiska Croubels

2014

A model based analysis of IPEC dosing of paclitaxel in rats

Pieter ColinLieselotte De SmetChris VervaetJean Paul RemonWim CeelenJan Van BocxlaerKoen BousseryAn Vermeulen

A1 Journal Article in PHARMACEUTICAL RESEARCH

Disulfiram inhibition of cyanide formation after acetonitrile poisoning

Peter De PaepePieter ColinPieter DepuydtAn-Sofie DecaveleJulie De SmetKoen BousseryChristophe StoveDominique BenoitAlain VerstraeteJan Van Bocxlaer et al.

Enzymatic tumour tissue digestion coupled to SPE-UPLC–tandem mass spectrometry as a tool to explore paclitaxel tumour penetration

Pieter ColinLieselotte De SmetLies De BockWim GoeteynKoen BousseryChris VervaetJan Van Bocxlaer

A1 Journal Article in TALANTA

Formulation of itraconazole nanococrystals and evaluation of their bioavailability in dogs

Lieselotte De SmetLien SaerensThomas De BeerRobert CarleerPeter AdriaensensJan Van BocxlaerChris VervaetJean Paul Remon

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Medication management in Belgian residential care facilities for individuals with intellectual disability: an observational study

Elke JoosEls MehuysJan Van BocxlaerJean Paul RemonMyriam Van WinckelKoen Boussery

A1 Journal Article in JOURNAL OF POLICY AND PRACTICE IN INTELLECTUAL DISABILITIES

Microsomal protein per gram of liver (MPPGL) in paediatric biliary atresia patients

Lies De BockKoen BousseryRuth De BruyneMyriam Van WinckelXavier StephenneEtienne SokalJan Van Bocxlaer

A1 Journal Article in BIOPHARMACEUTICS & DRUG DISPOSITION

Moxifloxacin dosing in post-bariatric surgery patients

Pieter ColinDouglas J EleveldMichel StruysHuybrecht T'jollynLucas Van BortelJohannes RuigeJan De WaeleJan Van BocxlaerKoen Boussery

A1 Journal Article in BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Pharmacokinetics in children with liver disease : can ex vivo obtained population-specific CYP450 characteristics bridge the knowledge gap?

Lies De BockJan Van BocxlaerKoen Boussery

Quantification of cytochrome 2E1 in human liver microsomes using a validated indirect ELISA

Lies De BockPieter ColinKoen BousseryJan Van Bocxlaer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Towards model-based dose optimization of antibiotic and anti-cancer treatment regimens in specific patient populations

Pieter ColinJan Van BocxlaerKoen BousseryAn Vermeulen

Untargeted screening of secondary metabolites in fungal cultures and samples from mouldy indoor environments by time-of-flight mass spectrometry

Svetlana MalyshevaViviana PolizziAntonio MorettiCarlos Van PeteghemNorbert De KimpeJan Van BocxlaerJosé Diana Di MavunguSarah De Saeger

A1 Journal Article in WORLD MYCOTOXIN JOURNAL

2013

Development and validation of a fast and uniform approach to quantify β-lactam antibiotics in human plasma by solid phase extraction-liquid chromatography-electrospray-tandem mass spectrometry

Pieter ColinLies De BockHuybrecht T'jollynKoen BousseryJan Van Bocxlaer

A1 Journal Article in TALANTA

Formulation of poorly water-soluble drugs via coacervation : a pilot study using febantel

Wesley De JaeghereBruno De GeestJan Van BocxlaerJean Paul RemonChris VervaetAndré Antunes

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Hepatic and intestinal CYP3A expression and activity in broilers

Ann OsselaereLies De BockVenessa EeckhautPatrick De BackerJan Van BocxlaerKoen BousserySiska Croubels

A1 Journal Article in JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS

In vitro cytochrome P450 activity decreases in children with high paediatric end-stage liver disease scores

Lies De BockKoen BousseryMyriam Van WinckelPeter De PaepeXavier RogiersXavier StephenneEtienne SokalJan Van Bocxlaer

A1 Journal Article in DRUG METABOLISM AND DISPOSITION

Metabolism of hop-derived bitter acids

Ko CattoorMichael DreselLies De BockKoen BousseryJan Van BocxlaerJean Paul RemonDenis De KeukeleireDieter DeforceThomas HofmannArne Heyerick

A1 Journal Article in JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The influence of bypass procedures and other anatomical changes in the gastrointestinal tract on the oral bioavailability of drugs

Julie De SmetJan Van BocxlaerKoen Boussery

A1 Journal Article in JOURNAL OF CLINICAL PHARMACOLOGY

The mycotoxin T-2 inhibits hepatic cytochrome P4503A activity in pigs

Joline GoossensLies De BockAnn OsselaereElin VerbruggheMathias DevreeseKoen BousseryJan Van BocxlaerPatrick De BackerSiska Croubels

A1 Journal Article in FOOD AND CHEMICAL TOXICOLOGY

Toxic effects of dietary exposure to T-2 toxin on intestinal and hepatic biotransformation enzymes and drug transporter systems in broiler chickens

Ann OsselaereShaoji LiLies De BockMathias DevreeseJoline GoossensVirginie VandenbrouckeJan Van BocxlaerKoen BousseryFrank PasmansAn Martel et al.

A1 Journal Article in FOOD AND CHEMICAL TOXICOLOGY

2012

Analytical performance evaluation of four cartridge-type blood gas analyzers

ANNE-SOPHIE DE KONINCKKoen De DeckerJan Van BocxlaerPeter MeeusLieve Van Hoovels

A1 Journal Article in CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Development and validation of a fast and sensitive UPLC-MS/MS method for the quantification of six probe metabolites for the in vitro determination of cytochrome P450 activity

Lies De BockKoen BousseryPieter ColinJulie De SmetHuybrecht T'jollynJan Van Bocxlaer

A1 Journal Article in TALANTA

Development and validation of an enzyme-linked immunosorbent assay for the quantification of cytochrome 3A4 in human liver microsomes

Lies De BockPieter ColinKoen BousseryJan Van Bocxlaer

A1 Journal Article in TALANTA

Development of a nanocrystalline Paclitaxel formulation for HIPEC treatment

Lieselotte De SmetPieter ColinWim CeelenMarc BrackeJan Van BocxlaerJean Paul RemonChris Vervaet

A1 Journal Article in PHARMACEUTICAL RESEARCH

Flavonoid deactivation of excited state flavins: reaction monitoring by mass spectrometry

Kevin HuvaereBart SinnaeveJan Van BocxlaerLeif H Skibsted

A1 Journal Article in JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Hypervariable cytochrome P450 activity in children with severe hepatic dysfunction

Lies De BockKoen BousseryMyriam Van WinckelPeter De PaepeXavier StephenneEtienne SokalJan Van Bocxlaer

Impact of corneal cross-linking on drug penetration in an ex vivo porcine eye model

Markus TschoppJohannes StaryBeatrice E FruehWolfgang ThormannJulie De SmetJan Van BocxlaerChristoph Tappeiner

A1 Journal Article in CORNEA

Oral bioavailability of moxifloxacin after Roux-en-Y gastric bypass surgery

Julie De SmetPieter ColinPeter De PaepeJohannes RuigeHélène BatensYves Van NieuwenhoveDirk VogelaersStijn BlotJan Van BocxlaerLucas Van Bortel et al.

A1 Journal Article in JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Switch from intravenous to enteral moxifloxacin in critically ill patients: a pilot study

Julie De SmetKirsten ColpaertPeter De PaepeJan Van BocxlaerJohan DecruyenaereKoen Boussery

A1 Journal Article in SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES

The impact of a changed anatomy of the gastrointestinal tract on the bioavailability of proton pump inhibitors and fluoroquinolone antibiotics

Julie De SmetJan Van BocxlaerKoen Boussery

2011

An evaluation of using population pharmacokinetic models to estimate pharmacodynamic parameters for propofol and bispectral index in children

Marc CoppensDouglas J EleveldJohannes H ProostLuc MarksJan Van BocxlaerHugo VereeckeAnthony R AbsalomMichel Struys

A1 Journal Article in ANESTHESIOLOGY

Bioavailability of hop-derived iso-α-acids and reduced derivatives

Ko CattoorJean Paul RemonKoen BousseryJan Van BocxlaerMarc BrackeDenis De KeukeleireDieter DeforceArne Heyerick

A1 Journal Article in FOOD & FUNCTION

Evaluation of three state-of-the-art metabolite prediction software packages (Meteor, MetaSite, and StarDrop) through independent and synergistic use

Huybrecht T'jollynKoen BousseryRJ Mortishire-SmithK CoeB De BoeckJan Van BocxlaerG Mannens

A1 Journal Article in DRUG METABOLISM AND DISPOSITION

Human salivary cortisol, part I : development and full validation of an LC-MS/MS based method

Mieke CarlierKathleen DeiterenJan Van BocxlaerKathleen Croes

In vitro cytochrome P450 activity: development and validation of a sensitive high performance liquid chromatography–tandem mass spectrometry method for the quantification of six probe metabolites after derivatization with pyridine-3-sulfonyl chloride in an aqueous environment

Lies De BockSofie Vande CasteeleSYLVIE MULLIEZKoen BousseryJan Van Bocxlaer

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY A

Pharmacokinetics of two formulations of omeprazole administered through a gastrostomy tube in patients with severe neurodevelopmental problems

Koen BousseryJulie De SmetPieter De CockSaskia Vande VeldeEls MehuysPeter De PaepeJean Paul RemonJan Van BocxlaerMyriam Van Winckel

A1 Journal Article in BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

2010

A bio-analytical hydrophilic interaction LC-MS/MS method for the simultaneous quantification of omeprazole and lansoprazole in human plasma in support of a pharmacokinetic omeprazole study in children

Julie De SmetKoen BousseryPieter De CockPeter De PaepeJean Paul RemonMyriam Van WinckelJan Van Bocxlaer

A1 Journal Article in JOURNAL OF SEPARATION SCIENCE

A comprehensive LC-MS-based quantitative analysis of fentanyl-like drugs in plasma and urine

Sarah CooremanChrista DeprezFrank MartensJan Van BocxlaerKathleen Croes

A1 Journal Article in JOURNAL OF SEPARATION SCIENCE

A new discriminative criterion for the development of Franz diffusion tests for transdermal pharmaceuticals

Bram BaertJente BoonenChristian Paul G. BurvenichNathalie RocheFilip StillaertPhillip BlondeelJan Van BocxlaerBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

Analysis of omnoponum by surface-ionization mass spectrometry and liquid chromatography tandem mass spectrometry methods

Dilshadbek UsmanovUsman KhasanovAleksey PantsirevJan Van Bocxlaer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Analytical characterization and comparison of the blood-brain barrier permeability of eight opioid peptides

Sylvia Van DorpeAntita AdriaensIngeborgh PolisKathelijne PeremansJan Van BocxlaerBart De Spiegeleer

A1 Journal Article in PEPTIDES

Mechanism of light-induced oxidation of nitrosylmyoglobin

Merete B MunkKevin HuvaereJan Van BocxlaerLeif H Skibsted

A1 Journal Article in FOOD CHEMISTRY

2009

Improved analyte detectability of proteins and peptide lysates by means of multiple large-volume injection in LC-MS

Michael StormeRuben T'KindtJan Van Bocxlaer

A1 Journal Article in JOURNAL OF SEPARATION SCIENCE

JEM Spotlight: Fungi, mycotoxins and microbial volatile organic compounds in mouldy interiors from water-damaged buildings

Viviana PolizziBarbara DelmulleAn AdamsA MorettiA SuscaAM PiccoYves RosseelRuben T'KindtJan Van BocxlaerNorbert De Kimpe et al.

A1 Journal Article in JOURNAL OF ENVIRONMENTAL MONITORING

Joint GC-MS and LC-MS platforms for comprehensive plant metabolomics: Repeatability and sample pre-treatment

Ruben T'KindtKris MorreelDieter DeforceWout BoerjanJan Van Bocxlaer

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Pharmacokinetics of fluoroquinolones in critical care patients: A bio-analytical HPLC method for simultaneous quantification of ofloxacin, ciprofloxacin and moxifloxacin in human plasma

Julie De SmetKoen BousseryKirsten ColpaertPeter De SutterPeter De PaepeJohan DecruyenaereJan Van Bocxlaer

A1 Journal Article in Journal of Chromatography B

2008

Analysis of oligonucleotides using capillary zone electrophoresis and electrospray mass spectrometry

An WillemsDieter DeforceJan Van Bocxlaer

Bookchapter in Capillary electrophoresis

Evaluation of hydrophilic interaction chromatography versus reversed-phase chromatography in a plant metabolomics perspective

Ruben T'KindtMichael StormeDieter DeforceJan Van Bocxlaer

A1 Journal Article in JOURNAL OF SEPARATION SCIENCE

LC-MS metabolic profiling of Arabidopsis thaliana plant leaves and cell cultures: optimization of pre-LC-MS procedure parameters

Ruben T'KindtLieven De VeylderMichael StormeDieter DeforceJan Van Bocxlaer

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Monitoring the benzene contents in soft drinks using headspace gas chromatography-mass spectrometry: A survey of the situation on the Belgian market

Christof Van PouckeChristel DetavernierJan Van BocxlaerRudi VermeylenCarlos Van Peteghem

A1 Journal Article in JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Quantitative determination of glycopyrrolate in human plasma by liquid chromatography-electrospray ionization mass spectrometry: The use of a volatile ion-pairing agent during both liquid-liquid extraction and liquid chromatography

ML StormeRuben T'KindtWim GoeteynKOEN REYNTJENSJan Van Bocxlaer

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

2007

Broad-spectrum separations in metabolomics using enhanced polar LC stationary phases: A dedicated evaluation using plant metabolites

Ruben T'KindtG ALAERTSY VANDER HEYDENDieter DeforceJan Van Bocxlaer

A1 Journal Article in JOURNAL OF SEPARATION SCIENCE

Comparison of two compartmental pharmacokinetics models to predict the time course of propofol plasma concentration during the first 5 minutes after a bolus injection

Hilde Van KerckhovenEric MortierJan Van BocxlaerMichel Struys

A2 Journal Article in ACTA ANAESTHESIOLOGICA BELGICA

Influence of administration rate on propofol plasma - Effect site equilibration

Michel StruysMarc CoppensN DE NEVEEric MortierAG DOUFASJan Van BocxlaerSL SHAFER

A1 Journal Article in ANESTHESIOLOGY

Postmortem distribution of 3,4-methylenedioxy-N,N-dimethyl-amphetamine (MDDM or MDDA) in a fatal MDMA overdose

Els De LetterWilly LambertMPLA BOUCHEJACM CORDONNIERJan Van BocxlaerMichel Piette

A1 Journal Article in INTERNATIONAL JOURNAL OF LEGAL MEDICINE

The occurrence of benzene in soft drinks : a survey of the situation on the Belgian market.

Christof Van PouckeChristel DetavernierJan Van BocxlaerReinhilde VermeylenCarlos Van Peteghem

2006

Class identity assignment for amphetamines using neural networks and GC-FTIR data

S GosavMirela PraislerJan Van BocxlaerAndreas De LeenheerDesiré L Massart

A1 Journal Article in SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Flavin-induced photodecomposition of sulfur-containing amino acids is decisive in the formation of beer lightstruck flavor

Kevin HuvaereML ANDERSENMichael StormeJan Van BocxlaerLH SKIBSTEDDenis De Keukeleire

A1 Journal Article in PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Quantitation of artemisinin and its biosynthetic precursors in Artemisia annua L. by high performance liquid chromatography - electrospray quadrupole time-of-flight tandem mass spectrometry

Filip Van NieuwerburghSofie Vande CasteeleLies MaesAlain GoossensDirk InzéJan Van BocxlaerDieter Deforce

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY A

Simultaneous quantitative analysis of the antimalarials pyrimethamine and sulfamethoxypyrazine in plasma samples using liquid chromatography/tandem mass spectrometry

Michael StormeFH JANSENW GOETEYNJan Van Bocxlaer

A1 Journal Article in RAPID COMMUNICATIONS IN MASS SPECTROMETRY

2005

Analysis of nucleic acid constituents by on-line capillary electrophoresis-mass spectrometry

An WillemsDieter DeforceCarlos Van PeteghemJan Van Bocxlaer

A1 Journal Article in ELECTROPHORESIS

Capillary liquid chromatography and tandem mass spectrometry for the quantification of enkephalins in cerebrospinal fluid

Bart SinnaeveMichael StormeJan Van Bocxlaer

A1 Journal Article in JOURNAL OF SEPARATION SCIENCE

Confirmation of the identity of residues using quadrupole time-of-flight mass spectrometry

Jan Van BocxlaerSofie Vande CasteeleChristof Van PouckeCarlos Van Peteghem

A1 Journal Article in ANALYTICA CHIMICA ACTA

Development of a quality control method for the characterization of oligonucleotides by capillary zone electrophoresis-electrospray ionization-quadrupole time of flight-mass spectrometry

An WillemsDieter DeforceCarlos Van PeteghemJan Van Bocxlaer

A1 Journal Article in ELECTROPHORESIS

Differential proteome analysis of Chronic lymphocytic leukemia subtypes

Ben GeeraertsAline DhondtDirk ElewautJan Van BocxlaerDieter Deforce

Exploring and modelling the responses of electrospray and atmospheric pressure chemical ionization techniques based on molecular descriptors

S CAETANOT DECAESTECKERR PUTM DASZYKOWSKIJan Van BocxlaerY VANDER HEYDEN

A1 Journal Article in ANALYTICA CHIMICA ACTA

LC-MS/MS in the elucidation of an isomer of the recreational drug methylenedioxy ethylamphetamine: Methylenedioxy dimethylamphetamine

Sofie Vande CasteeleMPL BOUCHEJan Van Bocxlaer

A1 Journal Article in JOURNAL OF SEPARATION SCIENCE

Liquid chromatographic-mass spectrometric assay for simultaneous pyrimethamine and sulfadoxine determination in human plasma samples

Bart SinnaeveTineke DecaesteckerPG RISHAJean Paul RemonChris VervaetJan Van Bocxlaer

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY A

Recent trends in analytical procedures in forensic toxicology

Jan Van Bocxlaer

A1 Journal Article in THERAPEUTIC DRUG MONITORING

The use of tryptic marker-peptides for the quantitative analysis of Cystatin C

Michael StormeBart SinnaeveJan Van Bocxlaer

A1 Journal Article in JOURNAL OF SEPARATION SCIENCE

2004

Evaluation of Nano-LC-MS/MS in a column switching setup as a tool for the absolute quantification of peptides in the picomolar range

Bart SinnaeveKarine ClauwaertJan Van Bocxlaer

Evaluation of nano-liquid chromatography-tandem mass spectrometry in a column switching setup for the absolute quantification of peptides in the picomolar range

Bart SinnaeveJan Van Bocxlaer

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY A

Information-dependent acquisition-mediated LC-MS/MS screening procedure with semiquantitative potential

TN DECAESTECKERSofie Vande CasteelePE WALLEMACQCarlos Van PeteghemDL DEFOREJan Van Bocxlaer

A1 Journal Article in ANALYTICAL CHEMISTRY

Interpretation of a 3,4-methylenedioxymethamphetamine (MDMA) blood level: discussion by means of a distribution study in two fatalities

Els De LetterMPLA BOUCHEJan Van BocxlaerWilly LambertMichel Piette

A1 Journal Article in FORENSIC SCIENCE INTERNATIONAL

Optimization of solid-phase extraction for a liquid chromatographic-tandem mass spectrometric general unknown screening procedure by means of computational techniques

Tineke DecaesteckerWilly LambertCarlos Van PeteghemDieter DeforceJan Van Bocxlaer

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY A

Photooxidative degradation of beer bittering principles: product analysis with respect to lightstruck flavour formation

Kevin HuvaereBart SinnaeveJan Van BocxlaerDenis De Keukeleire

A1 Journal Article in PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Production of compound A and carbon monoxide in circle systems : an in vitro comparison of two carbon dioxide absorbents

Michel StruysMPLA BoucheGeorges RollyYDI VandevivereDORINE DYZERSWim GoeteynLinda VersichelenJan Van BocxlaerEric Mortier

A1 Journal Article in ANAESTHESIA

Rapid characterization of oligonucleotides by capillary liquid chromatography-nano electrospray quadrupole time-of-flight mass spectrometry

An WillemsDieter DeforceWilly LambertCarlos Van PeteghemJan Van Bocxlaer

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY A

The determination of cocaine, benzoylecgonine, and cocaethylene in small-volume oral fluid samples by liquid chromatography-quadrupole-time-of-flight mass spectrometry

K CLAUWAERTT DECALESTECKERKjell MortierWilly LambertDieter DeforceCarlos Van PeteghemJan Van Bocxlaer

A1 Journal Article in JOURNAL OF ANALYTICAL TOXICOLOGY

2003

Confirmation of ofloxacin precipitation in corneal deposits by microbore liquid chromatography - quadrupole time-of-flight tandem mass spectrometry

Bart SinnaeveTineke DecaesteckerIlse ClaerhoutPhilippe KestelynJean Paul RemonJan Van Bocxlaer

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Corneal deposits after the topical use of ofloxacin in two children with vernal keratoconjunctivitis

Ilse ClaerhoutPhilippe KestelynFrançoise MeireJean Paul RemonTineke DecaesteckerJan Van Bocxlaer

A1 Journal Article in BRITISH JOURNAL OF OPHTHALMOLOGY

Exact mass measurement of product ions for the structural confirmation and identification of unknown compounds using a quadrupole time-of-flight spectrometer: a simplified approach using combined tandem mass spectrometric functions

Karine ClauwaertSofie Vande CasteeleBart SinnaeveDieter DeforceWilly LambertCarlos Van PeteghemJan Van Bocxlaer

A1 Journal Article in RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Immunohistochemical demonstration of the amphetamine derivatives 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxyamphetamine (MDA) in human post-mortem tissues

Els De LetterMarc EspeelMarijke CraeymeerschWilly LambertJan Van BocxlaerMichel Piette

Presence of N,N-Dimethyl-3,4-Methylenedioxyamphetamine(MDDM) in a fatal MDMA-overdose

M BOUCHEEls De LetterSofie Vande CasteelePhilippe Van RompaeyMichel PietteJan Van Bocxlaer

Suitability testing of commercial solid-phase extraction sorbents for sample clean-up in systematic toxicological analysis using liquid chromatography-(tandem) mass spectrometry

Tineke DecaesteckerEM COOPMANCarlos Van PeteghemJan Van Bocxlaer

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

The protein expression pattern of CLL cells is stable over six months intervals

Ben GeeraertsJan Van BocxlaerWilly LambertCarlos Van PeteghemDieter DeforceDirk Elewaut

2002

Analysis of benzo(a)pyrene diol epoxide-DNA adducts by capillary zone electrophoresis-electrospray ionization-mass spectrometry in conjunction with sample stacking

An WillemsDieter DeforceElfrida Van Den EeckhoutWilly LambertCarlos Van PeteghemAndreas De LeenheerJan Van Bocxlaer

A1 Journal Article in ELECTROPHORESIS

Automated recognition of ergogenic aids using Soft Independent Modeling of Class Analogy (SIMCA)

M PraislerJan Van BocxlaerAndreas De LeenheerDL Massart

A1 Journal Article in TURKISH JOURNAL OF CHEMISTRY

Chemometric detection of thermally degraded samples in the analysis of drugs of abuse with gas chromatography-Fourier-transform infrared spectroscopy

M PraislerJan Van BocxlaerAndreas De LeenheerDL Massart

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY A

Distribution profile study of 4-MTA based on a fatal intoxication.

Tineke DecaesteckerE DE LETTERKarine ClauwaertMarie-Paule BoucheWilly LambertJan Van BocxlaerM PIETTEE VAN DEN EECKHOUTCarlos Van PeteghemAndreas De Leenheer

Distribution study of 3,4-methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine in a fatal overdose

Els De LetterKarine ClauwaertWilly LambertJan Van BocxlaerAndreas De LeenheerMichel Piette

A1 Journal Article in JOURNAL OF ANALYTICAL TOXICOLOGY

No Compound A formation with Superia (R) during minimal-flow sevoflurane anesthesia : a comparison with Sofnolime

Marie-Paule BoucheLinda VersichelenMichel StruysJan Van BocxlaerAndreas De LeenheerEric MortierGeorges Rolly

A1 Journal Article in ANESTHESIA AND ANALGESIA

Post-mortem redistribution of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") in the rabbit Part I - experimental approach after in vivo intravenous infusion.

Els De LetterKarine ClauwaertFrans BelpaireWilly LambertJan Van BocxlaerMichel Piette

A1 Journal Article in INTERNATIONAL JOURNAL OF LEGAL MEDICINE

Post-mortem redistribution of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") in the rabbit Part II: post-mortem infusion in trachea or stomach.

Els De LetterFrans BelpaireKarine ClauwaertWilly LambertJan Van BocxlaerMichel Piette

A1 Journal Article in INTERNATIONAL JOURNAL OF LEGAL MEDICINE

Quantitative determination of n-propane, iso-butane, and n-butane by headspace GC-MS in intoxications by inhalation of lighter fluid

Marie-Paule BoucheWilly LambertJan Van BocxlaerMichel PietteAndreas De Leenheer

A1 Journal Article in JOURNAL OF ANALYTICAL TOXICOLOGY

Simultaneous, quantitative determination of opiates, amphetamines, cocaine and benzoylecgonine in oral fluid by liquid chromatography quadrupole-time-of-flight mass spectrometry

Kjell MortierKristof MaudensWilly LambertKarine ClauwaertJan Van BocxlaerDieter DeforceCarlos Van PeteghemAndreas De Leenheer

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

2001

A fatal case of moclobemide-citalopram intoxication : reply

Riet DamsTom BenijtsWilly LambertJan Van BocxlaerCarlos Van PeteghemAndreas De LeenheerD Van Varenbergh

A1 Journal Article in JOURNAL OF ANALYTICAL TOXICOLOGY

A fatal case of serotonin syndrome after combined moclobemide-citalopram intoxication

Riet DamsTom BenijtsWilly LambertJan Van BocxlaerD Van VarenberghCV PeteghemAndreas De Leenheer

A1 Journal Article in JOURNAL OF ANALYTICAL TOXICOLOGY

A fatal case of serotonin syndrome after combined moclobemide-citalopram intoxication

Riet DamsTom BenijtsWilly LambertJan Van BocxlaerD VAN VARENBERGHAndreas De Leenheer

A structured approach for screening the relevant factors in a PTV injection optimizing procedure

Marie-Paule BoucheM PRAISLERJan Van BocxlaerAndreas De Leenheer

Compound A production from sevoflurane is not less when KOH-free absorbent is used in a closed-circuit lung model system

Linda VersichelenMarie-Paule BoucheMichel StruysJan Van BocxlaerEric MortierAndreas De LeenheerGeorges Rolly

A1 Journal Article in BRITISH JOURNAL OF ANAESTHESIA

Computer-aided screening for hallucinogenic and stimulant amphetamines with gas chromatography-Fourier transform infrared spectroscopy (GC-FTIR)

M PraislerInge DirinckJan Van BocxlaerAndreas De LeenheerDL Massart

A1 Journal Article in JOURNAL OF ANALYTICAL TOXICOLOGY

Evaluation of automated MS to MS/MS function switching for comprehensive drug profiling analysis using a quadrupole time-of-flight mass spectrometer

Tineke DecaesteckerKarine ClauwaertJan Van BocxlaerWilly LambertE VAN DEN EECKHOUTC VAN PETEGHEM

Bookchapter in Advances in Mass Spectrometry. E. Gelpi, Editor, John Wiley & Sons Ltd. Chichester, 2001, vol. 15, 2 pp

Fatal 4-MTA intoxication : development of a liquid chromatographic-tandem mass spectrometric assay for multiple matrices

Tineke DecaesteckerEls De LetterKarine ClauwaertMarie-Paule BoucheWilly LambertJan Van BocxlaerMichel PietteElfrida Van Den EeckhoutCarlos Van PeteghemAndreas De Leenheer

A1 Journal Article in JOURNAL OF ANALYTICAL TOXICOLOGY

Multivariate determination of the length of the side chain of illicit amphetamine analogues with GC-FTIR spectra.

M PRAISLERJan Van BocxlaerAndreas De LeenheerDL MASSART

A2 Journal Article in The Annals of the University 'Dunãrea de Jos', Fascicle II, XVIII, 2000

Only carbon dioxide absorbents free of both NaOH and KOH do not generate compound A during in vitro closed-system sevoflurane : evaluation of five absorbents

Linda VersichelenMarie-Paule BoucheGeorges RollyJan Van BocxlaerMichel StruysAndreas De LeenheerEric Mortier

A1 Journal Article in ANESTHESIOLOGY

Pitfalls associated with liquid chromatography/electrospray tandem mass spectrometry in quantitative bioanalysis of drugs of abuse in saliva

Kjell MortierKarine ClauwaertWilly LambertJan Van BocxlaerElfrida Van Den EeckhoutCarlos Van PeteghemAndreas De Leenheer

A1 Journal Article in RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Quantitation of amphetamine, methamphetamine, MDA, MDMA and MDEA in saliva with a Q-TOF LC/MS/MS system

Karine ClauwaertJan Van BocxlaerAn WillemsKjell MortierWilly LambertE VAN DEN EECKHOUT

Quantitation of cocaine, benzoylecgonine and cocaethylene in saliva with a LC/MS/MS using small sample volumes

Karine ClauwaertJan Van BocxlaerTineke DecaesteckerKjell MortierWilly LambertE VAN DEN EECKHOUTCarlos Van Peteghem

Quantitative GC-MS of volatiles : compound A determination in the vapor phase of sevoflurane based anesthesia systems

Marie-Paule BoucheJan Van BocxlaerG ROLLYL VERSICHELENM STRUYSE MORTIERWilly LambertAndreas De Leenheer

Quantitative determination of n-propane, isobutane and n-nutane by headspace GC-MS in a fatal intoxication by inhalation of lighter fluid

Marie-Paule BoucheWilly LambertJan Van BocxlaerM PIETTEAndreas De Leenheer

Quantitative determination of vapor-phase compound A in sevoflurane anesthesia using gas chromatography-mass spectrometry

Marie-Paule BoucheJan Van BocxlaerGeorges RollyLinda VersichelenMichel StruysEric MortierAndreas De Leenheer

A1 Journal Article in CLINICAL CHEMISTRY

Stability study of the designer drugs 'MDA, MDMA and MDEX' in water, serum, whole blood, and urine under various storage temperatures

Karine ClauwaertJan Van BocxlaerAndreas De Leenheer

A1 Journal Article in FORENSIC SCIENCE INTERNATIONAL

2000

Comparison between automated knowledge-based systems identifying and classifying amphetamine analogues using vapor-phase FTIR-spectra and mass spectra.

Inge DirinckM PRAISLERJan Van BocxlaerAndreas De LeenheerDL MASSART

A2 Journal Article in The 37th triennial Meeting of The International Association of Forensic Toxicologists / Lech T, Wójcikiewicz J., Eds. - Krakow : Institute of Forensic Research Publishers, 2000 - 5 pp.

Comparison of an enzymatic alcohol dehydrogenase assay and alcohol headspace GC-FID method using statistical analysis on real forensic blood and urine samples.

Katrien ArysJan Van BocxlaerWilly LambertCarlos Van PeteghemAndreas De Leenheer

A2 Journal Article in The 37th triennial Meeting of The International Association of Forensic Toxicologists / Lech T, Wójcikiewicz J., Eds. - Krakow : Institute of Forensic Research Publishers, 2000 - 4 pp.

Determination of the designer drugs 3,4-methylenedioxymethamphetamine, 3,4-methylenedioxyethylamphetamine, and 3,4-methylenedioxyamphetamine with HPLC and fluorescence detection in whole blood, serum, vitreous humor, and urine

Karine ClauwaertJan Van BocxlaerEls De LetterSerge Van CalenberghWilly LambertAndreas De Leenheer

A1 Journal Article in CLINICAL CHEMISTRY

Evaluation of automated single mass spectrometry to tandem mass spectrometry function switching for comprehensive drug profiling analysis using a quadrupole time-of-flight mass spectrometer

Tineke DecaesteckerKarine ClauwaertJan Van BocxlaerWilly LambertElfrida Van Den EeckhoutCarlos Van PeteghemAndreas De Leenheer

A1 Journal Article in RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Exploratory analysis for the automated identification of amphetamines from vapour-phase FTIR spectra

M PraislerInge DirinckJan Van BocxlaerAndreas De LeenheerDL Massart

A1 Journal Article in ANALYTICA CHIMICA ACTA

Identification of novel illicit amphetamines from vapor-phase FTIR spectra - a chemometrical solution

M PraislerInge DirinckJan Van BocxlaerAndreas De LeenheerDL Massart

A1 Journal Article in TALANTA

In vitro compound A formation in a computer-controlled closed-circuit anesthetic apparatus : comparison with a classical valve circuit

Linda VersichelenGeorges RollyMarie-Paule BoucheJan Van BocxlaerMichel StruysC Van der HertenAndreas De LeenheerEric Mortier

A1 Journal Article in ANESTHESIOLOGY

Is vitreous humour useful for the interpretation of 3,4-methylenedioxymethamphetamine (MDMA) blood levels? Experimental approach with rabbits

Els De LetterPeter De PaepeKarine ClauwaertFrans BelpaireWilly LambertJan Van BocxlaerMichel Piette

A1 Journal Article in INTERNATIONAL JOURNAL OF LEGAL MEDICINE

Liquid chromatography-mass spectrometry in forensic toxicology

Jan Van BocxlaerKarine ClauwaertWilly LambertDieter DeforceElfrida Van Den EeckhoutAndreas De Leenheer

A1 Journal Article in MASS SPECTROMETRY REVIEWS

Modern chromatographic analysis of vitamins (Third edition, revised and expanded)

Pattern recognition techniques screening for drugs of abuse with gas chromatography-Fourier transform infrared spectroscopy

M PraislerInge DirinckJan Van BocxlaerAndreas De LeenheerDL Massart

A1 Journal Article in TALANTA

Quantitative determination of paraquat by HPLC-DAD following chemical reduction with sodium borohydride in a fatal intoxication

Katrien ArysJan Van BocxlaerKarine ClauwaertWilly LambertMichel PietteCarlos Van PeteghemAndreas De Leenheer

Quantitative determination of paraquat in a fatal intoxication by HPLC-DAD following chemical reduction with sodium borohydride

Katrien ArysJan Van BocxlaerKarine ClauwaertWilly LambertMichel PietteCarlos Van PeteghemAndreas De Leenheer

A1 Journal Article in JOURNAL OF ANALYTICAL TOXICOLOGY

Segmental analysis for cocaine and metabolites by HPLC in hair of suspected drug overdose cases

Karine ClauwaertJan Van BocxlaerWilly LambertAndreas De Leenheer

A1 Journal Article in FORENSIC SCIENCE INTERNATIONAL

Toxicological analysis : liquid chromatography

Andreas De LeenheerWilly LambertJan Van Bocxlaer

Bookchapter in Encyclopedia of Separation Science

1999

Investigation of the quantitative properties of the quadrupole orthogonal acceleration time-of-flight mass spectrometer with electrospray ionisation using 3,4-methylenedioxymethamphetamine

Karine ClauwaertJan Van BocxlaerHJ MajorJA ClaereboudtWilly LambertElfrida Van Den EeckhoutCarlos Van PeteghemAndreas De Leenheer

A1 Journal Article in RAPID COMMUNICATIONS IN MASS SPECTROMETRY

1998

Application of gas chromatography-Fourier transform infrared spectrometry to the analysis of amphetamine analogues

Inge DirinckEvelyne MeyerJan Van BocxlaerWilly LambertAndreas De Leenheer

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY A

Narrow-bore HPLC in combination with fluorescence and electrospray mass spectrometric detection for the analysis of cocaine and metabolites in human hair

Karine ClauwaertJan Van BocxlaerWilly LambertElfrida Van Den EeckhoutF LemièreEL EsmansAndreas De Leenheer

A1 Journal Article in ANALYTICAL CHEMISTRY

1997

Liquid chromatographic determination of cocaine, benzoylecgonine, and cocaethylene in whole blood and serum samples with diode-array detection

Karine ClauwaertJan Van BocxlaerWilly LambertAndreas De Leenheer

A1 Journal Article in JOURNAL OF CHROMATOGRAPHIC SCIENCE

Potential of high-performance liquid chromatography with photodiode array detection in forensic toxicology

Willy LambertJan Van BocxlaerAndreas De Leenheer

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY B

Quantitative colorimetric determination of urinary p-aminophenol with an automated analyzer

Jan Van BocxlaerKarine ClauwaertWilly LambertAndreas De Leenheer

A1 Journal Article in CLINICAL CHEMISTRY

Quantitative determination of amphetamine and α-phenylethylamine enantiomers in judicial samples using capillary gas chromatography

Jan Van BocxlaerWilly LambertLinda ThienpontAndreas De Leenheer

A1 Journal Article in JOURNAL OF ANALYTICAL TOXICOLOGY

Relevance of toxicological screening for chloroquine in nonmalarious areas

Willy LambertEvelyne MeyerJan Van BocxlaerAndreas De LeenheerMichel Piette

A1 Journal Article in JOURNAL OF ANALYTICAL TOXICOLOGY

Tissue distribution of amphetamine isomers in a fatal overdose

Evelyne MeyerJan Van BocxlaerInge DirinckWilly LambertLinda ThienpontAndreas De Leenheer

A1 Journal Article in JOURNAL OF ANALYTICAL TOXICOLOGY

1996

Analysis of Zopiclone (Imovane(R)) in postmortem specimens by GC-MS and HPLC with diode-array detection

Jan Van BocxlaerEvelyne MeyerKarine ClauwaertWilly LambertMichel PietteAndreas De Leenheer

A1 Journal Article in JOURNAL OF ANALYTICAL TOXICOLOGY

Analysis of cocaine, benzoylecgonine, and cocaethylene in urine by HPLC with diode array detection

Karine ClauwaertJan Van BocxlaerWilly LambertAndreas De Leenheer

A1 Journal Article in ANALYTICAL CHEMISTRY

Identification of a-Phenylethylamine in Judicial Samples

Evelyne MeyerJan Van BocxlaerWilly LambertLinda ThienpontAndreas De Leenheer

A2 Journal Article in Journal Anal. Toxicol., 20, pp. 116-120, 4 figg., 1 tab

Identification of α-phenylethylamine in judicial samples

Evelyne MeyerJan Van BocxlaerWilly LambertLinda ThienpontAndreas De Leenheer

A1 Journal Article in JOURNAL OF ANALYTICAL TOXICOLOGY

Quantitative gas chromatographic analysis of 3-cyano-3,3-diphenylpropionic acid, the acidic metabolite of bezitramide (Burgodin((R))), in urine

Siegrid De BaereWilly LambertJan Van BocxlaerAndreas De Leenheer

A1 Journal Article in JOURNAL OF ANALYTICAL TOXICOLOGY

Trazodone and dothiepin poisoning : reply

Willy LambertJan Van BocxlaerMichel PietteAndreas De Leenheer

A1 Journal Article in JOURNAL OF ANALYTICAL TOXICOLOGY

Zopiclone poisoning : reply

Jan Van BocxlaerEvelyne MeyerKarine ClauwaertWilly LambertMichel PietteAndreas De Leenheer

A1 Journal Article in JOURNAL OF ANALYTICAL TOXICOLOGY

1995

Characterization of acylcarnitines using fast atom bombardment mass spectrometry and gas chromatography/mass spectrometry

Jan Van BocxlaerM CLAEYSH VANDENHEUVELAndreas De Leenheer

A1 Journal Article in JOURNAL OF MASS SPECTROMETRY

Determination of chloral hydrate and metabolites in a fatal intoxication

Evelyne MeyerJan Van BocxlaerWilly LambertMichel PietteAndreas De Leenheer

A1 Journal Article in JOURNAL OF ANALYTICAL TOXICOLOGY

α-Phenylethylamine identified in judicial samples

Evelyne MeyerJan Van BocxlaerWilly LambertLinda ThienpontAndreas De Leenheer

A1 Journal Article in FORENSIC SCIENCE INTERNATIONAL

1994

A fatal case of trazodone and dothiepin poisoning : toxicological findings

Willy LambertJan Van BocxlaerMichel PietteAndreas De Leenheer

A1 Journal Article in JOURNAL OF ANALYTICAL TOXICOLOGY

A fatal case of trazodone and dothiepin poisoning : toxicological findings

Willy LambertJan Van BocxlaerM PietteAndreas De Leenheer

Bookchapter in Contributions to Forensic Toxicology

Determination of embutramide in biological matrices by gas chromatography with nitrogen-phosphorus detection

JZ HUOJan Van BocxlaerWilly LambertAndreas De Leenheer

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS

1993

Solid-phase extraction technique for gas-chromatographic profiling of acylcarnitines

Jan Van BocxlaerAndreas De Leenheer

A1 Journal Article in CLINICAL CHEMISTRY

1992

Gas chromatographic/mass spectrometric identification of 3-hydroxydicarboxylic acids in urine

BJ VerhaegheJan Van BocxlaerAndreas De Leenheer

A1 Journal Article in BIOLOGICAL MASS SPECTROMETRY

Meprobamate intoxication : rare and difficult to find

Willy LambertAndreas De LeenheerJan Van BocxlaerMichel Piette

A1 Journal Article in JOURNAL OF TOXICOLOGY - CLINICAL TOXICOLOGY

G FaulerW MunteanHJ Leis

Bookchapter in Modern chromatographic analysis of vitamins

1989

Determination of pipecolic acid in serum or plasma by solid-phase extraction and isotope dilution mass spectrometry

Jan Van BocxlaerBJ VerhaegheAE WautersWD De MarezLinda ThienpontAndreas De Leenheer

A1 Journal Article in BIOMEDICAL AND ENVIRONMENTAL MASS SPECTROMETRY

Metabolic profiling of urinary organic acids by single and multicolumn capillary gas chromatography

MF LefevereBJ VerhaegheDH DeclerckJan Van BocxlaerAndreas De LeenheerRM De Sagher

A1 Journal Article in JOURNAL OF CHROMATOGRAPHIC SCIENCE