Research Explorer

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Researcher

Jan Tavernier

Awards & Distinctions

354 Results

2023

A bispecific Clec9A-PD-L1 targeted type I interferon profoundly reshapes the tumor microenvironment towards an antitumor state

Sandra Van LintAlexander Van ParysBram Van Den EeckhoutNiels VandammeStephane PlaisanceAnnick VerheeDominiek CatteeuwElke RoggeJennifer De GeestNele Vanderroost et al.

A1 Journal Article in MOLECULAR CANCER

Mechanism of receptor assembly via the pleiotropic adipokine Leptin

Alexandra TsirigotakiAnn DansercoerKoen VerschuerenIva MarkovićChristoph PollmannMaximillian HaferJan FélixCatherine BirckWouter Van PutteDominiek Catteeuw et al.

A1 Journal Article in NATURE STRUCTURAL & MOLECULAR BIOLOGY

2022

An unexpected encounter : respiratory syncytial virus nonstructural protein 1 interacts with mediator subunit MED25

Tessa Van RoyenKoen SedeynGeorgios MoschonasWendy ToussaintM VuylstekeDelphi Van HaverFrancis ImpensSven EyckermanIrma LemmensJan Tavernier et al.

A1 Journal Article in JOURNAL OF VIROLOGY

Direct and indirect anti-leukemic properties of Activity-on-Target interferons for the treatment of T-cell acute lymphoblastic leukemia

Steven GoossensAnje CauwelsTim PietersRenate De SmedtSara T'SasAndré Pedro Pinto De AlmeidaWillem DaneelsPieter Van VlierbergheJan Tavernier

A1 Journal Article in HAEMATOLOGICA

2021

Development of IL-1β AcTakines : towards new adjuvants in vaccination strategies

Bram Van Den EeckhoutSarah GerloJan Tavernier

Interleukin-1 as innate mediator of T cell immunity

Bram Van Den EeckhoutJan TavernierSarah Gerlo

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Prolyl endopeptidase-like is a (thio)esterase involved in mitochondrial respiratory chain function

Karen RosierMolly T. McDevittJoél SmetBrendan J. FloydMaxime VerschooreMaria J. MarcaidaCraig A. BingmanIrma LemmensMatteo Dal PeraroJan Tavernier et al.

A1 Journal Article in ISCIENCE

Selective IL-1 activity on CD8+ T cells empowers antitumor immunity and synergizes with neovasculature-targeted TNF for full tumor eradication

Bram Van Den EeckhoutLeander HuygheSandra Van LintElianne BurgStéphane PlaisanceFrank PeelmanAnje CauwelsGilles UzéNiko KleySarah Gerlo et al.

A1 Journal Article in JOURNAL FOR IMMUNOTHERAPY OF CANCER

Targeting IFN activity to both B cells and plasmacytoid dendritic cells induces a robust tolerogenic response and protection against EAE

Anje CauwelsSandra Van LintElke RoggeAnnick VerheeBram Van Den EeckhoutShengru PangMarco PrinzNiko KleyGilles UzeJan Tavernier

A1 Journal Article in SCIENTIFIC REPORTS

ZBTB32 performs crosstalk with the glucocorticoid receptor and is crucial in glucocorticoid responses to starvation

Lise Van WyngeneTineke VanderhaeghenIoanna PettaSteven TimmermansKatrien CorbeelsBart Van der SchuerenJolien VandewalleKelly Van LooverenCharlotte WallaeysMelanie Eggermont et al.

A1 Journal Article in ISCIENCE

2020

Mutations in the ubiquitin ligase adaptor LZTR1 drive human disease by dysregulating RAS ubiquitination and signaling.

Mikhail SteklovSilvia PandolfiMaria Francesca BaiettiPaolo CaraiMingzhen ZhangHyunbum JangYanyan CaiEric LegiusJan TavernierKris Gevaert et al.

Rapid and effective generation of nanobody based CARs using PCR and Gibson Assembly

Stijn De MunterAlexander Van ParysLayla BralJoline IngelsGlenn GoetgelukSarah BonteMelissa PilleLore BillietKarin WeeningAnnick Verhee et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Safe eradication of large established tumors using neovasculature-targeted tumor necrosis factor-based therapies

Leander HuygheAlexander Van ParysAnje CauwelsSandra Van LintStijn De MunterJennyfer BultinckLennart ZabeauJeroen HostensAn GoethalsNele Vanderroost et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

Selected IL-1 activity on CD8+ T cells allows for safe enhancement of cellular immune responses

Bram Van Den EeckhoutLien Van HoeckeElianne BurgSandra Van LintFrank PeelmanNiko KleyGilles UzéXavier SaelensJan TavernierSarah Gerlo

Specific targeting of IL-1β activity to CD8+ T cells allows for safe use as a vaccine adjuvant

Bram Van Den EeckhoutLien Van HoeckeElianne BurgSandra Van LintFrank PeelmanNiko KleyGilles UzéXavier SaelensJan TavernierSarah Gerlo

A1 Journal Article in NPJ VACCINES

Teaching an old dog new tricks : activity-on-target interferon to treat T-cell acute lymphoblastic leukemia

Steven GoossensAnje CauwelsTim PietersWillem DaneelsPieter Van VlierbergheJan Tavernier

2019

Discovering cellular protein-protein interactions : technological strategies and opportunities

Kevin TitecaIrma LemmensJan TavernierSven Eyckerman

A1 Journal Article in MASS SPECTROMETRY REVIEWS

Mechanisms underlying the functional cooperation between PPARα and GRα to attenuate inflammatory responses

Nadia BougarneViacheslav MylkaDariusz RatmanIlse BeckJonathan ThommisLode De CauwerJan TavernierBart StaelsClaude LibertKarolien De Bosscher

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Study of anti-inflammatory approaches as an alternative for glucocorticoids

Viacheslav MylkaKarolien De BosscherJan Tavernier

Targeting interferon activity to dendritic cells enables in vivo tolerization and protection against EAE in mice

Anje CauwelsSandra Van LintDominiek CatteeuwShengru PangFranciane PaulElke RoggeAnnick VerheeMarco PrinzNiko KleyGilles Uzé et al.

A1 Journal Article in JOURNAL OF AUTOIMMUNITY

Towards the use of interleukin-1β as vaccine adjuvant

Bram Van Den EeckhoutLien Van HoeckeElianne BurgSandra Van LintFrank PeelmanXavier SaelensJan TavernierSarah Gerlo

2018

Adding new nodes to the protein association network

Surya GuptaLennart MartensJan Tavernier

Co-activation of glucocorticoid receptor and peroxisome proliferator-activated receptor-γ in murine skin prevents worsening of atopic march

Julie DeckersNadia BougarneViacheslav MylkaSofie DesmetAstrid LuypaertMichael DevosGiel TangheJustine Van MoorleghemManon VanheerswynghelsLode De Cauwer et al.

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

Delivering type I interferon to dendritic cells empowers tumor eradication and immune combination treatments

Anje CauwelsSandra Van LintFranciane PaulGenevieve GarcinStefaan De KokerAlexander Van ParysThomas WüestSarah GerloJosé Van Der HeydenYan Bordat et al.

A1 Journal Article in CANCER RESEARCH

Effect of combining glucocorticoids with Compound A on glucocorticoid receptor responsiveness in lymphoid malignancies

Dorien ClarisseKarlien Van WesemaelJan TavernierFritz OffnerIlse BeckKarolien De Bosscher

A1 Journal Article in PLOS ONE

Germline gain-of-function myeloid differentiation primary response gene-88 (MYD88) mutation in a child with severe arthritis

Keith A SikoraJoshua R BennettLaurens VynckeZuoming DengWanxia Li TsaiEwald PauwelsGerlinde Layh-SchmittApril BrundidgeFatemeh NavidKristien JM Zaal et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

High-confidence interactome for RNF41 built on multiple orthogonal assays

Delphine MasschaeleJoris WaumanGiel VandemoorteleDelphine De SutterLeentje De CeuninckSven EyckermanJan Tavernier

A1 Journal Article in JOURNAL OF PROTEOME RESEARCH

IL-1β AcTaleukins : towards potent yet safe adjuvants for tumor vaccination

Bram Van Den EeckhoutElianne BurgAnje CauwelsFrank PeelmanSandra Van LintJan TavernierSarah Gerlo

KISS : a mammalian two-hybrid method for in situ analysis of protein-protein interactions

Delphine MasschaeleSarah GerloIrma LemmensSam LievensJan Tavernier

Bookchapter in Two-hybrid systems : methods and protocols

Modifying Rap1-signalling by targeting Pde6δ is neuroprotective in models of Alzheimer’s disease

Michael DumbacherTom Van DoorenKatrien PrincenKoen De WitteMélissa FarinelliSam LievensJan TavernierWim DehaenStefaan WeraJoris Winderickx et al.

A1 Journal Article in MOLECULAR NEURODEGENERATION

Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination

M SteklovS PandolfiMF BaiettiA BatiukP CaraiP NajmM ZhangH JangF RenziY Cai et al.

A1 Journal Article in SCIENCE

Nanoparticle-conjugate TLR7/8 agonist localized immunotherapy provokes safe antitumoral responses

Lutz NuhnStefaan De KokerSandra Van LintZifu ZhongJoão Portela CataniFrancis CombesKim DeswarteYupeng LiBart LambrechtStefan Lienenklaus et al.

A1 Journal Article in ADVANCED MATERIALS

Novel mechanisms controlling STAT3 transcriptional activity

Raffaele MoriJan Tavernier

Protein-protein interaction mapping to study the role of RNF41 in intracellular trafficking

Delphine MasschaeleJan Tavernier

Strategies and compounds to circumvent glucocorticoid-induced side effects

Astrid LuypaertWim Vanden BergheJan TavernierClaude LibertKarolien De Bosscher

Bookchapter in Immunopharmacology and inflammation

Structural and functional analysis of TIR domains in health and disease

Laurens VynckeFrank PeelmanJan Tavernier

Study of the transcriptional crosstalk between metabolic nuclear receptors

Sofie DesmetKarolien De BosscherJan Tavernier

The autophagy receptor SQSTM1/p62 mediates anti-inflammatory actions of the selective NR3C1/glucocorticoid receptor modulator compound A (CpdA) in macrophages

Viacheslav MylkaJulie DeckersDariusz RatmanLode De CauwerJonathan ThommisRiet De RyckeFrancis ImpensClaude LibertJan TavernierWim Vanden Berghe et al.

A1 Journal Article in AUTOPHAGY

The intracellular domain of the leptin receptor prevents mitochondrial depolarization and mitophagy

Joris WaumanJan Tavernier

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The online Tabloid Proteome : an annotated database of protein associations

Surya GuptaDemet TuranJan TavernierLennart Martens

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes

Lien Van HoeckeSandra Van LintKenny RooseAlexander Van ParysPeter VandenabeeleJohan GrootenJan TavernierStefaan De KokerXavier Saelens

A1 Journal Article in NATURE COMMUNICATIONS

2017

A safe and highly efficient tumor-targeted type I interferon immunotherapy depends on the tumor microenvironment

Anje CauwelsSandra Van LintGeneviève GarcinJennyfer BultinckFranciane PaulSarah GerloJosé Van Der HeydenYann BordatDominiek CatteeuwLode De Cauwer et al.

A1 Journal Article in ONCOIMMUNOLOGY

Analyzing trapped protein complexes by Virotrap and SFINX

Kevin TitecaEmmy Van QuickelbergheNoortje SamynDelphine De SutterAnnick VerheeKris GevaertJan TavernierSven Eyckerman

A1 Journal Article in NATURE PROTOCOLS

Compound A influences gene regulation of the dexamethasone-activated glucocorticoid receptor by alternative cofactor recruitment

Sofie DesmetNadia BougarneLaura Van MoortelLode De CauwerJonathan ThommisM VuylstekeDariusz RatmanR HoutmanJan TavernierKarolien De Bosscher

A1 Journal Article in SCIENTIFIC REPORTS

Coregulator profiling of the glucocorticoid receptor in lymphoid malignancies

Dorien ClarisseJonathan ThommisKarlien Van WesemaelRene HoutmanDariusz RatmanJan TavernierFritz OffnerIlse BeckKarolien De Bosscher

A1 Journal Article in ONCOTARGET

Glucocorticoid receptor-mediated transactivation is hampered by Striatin-3, a novel interaction partner of the receptor

Ioanna PettaNadia BougarneJolien VandewalleLien DejagerSofie VandevyverMarlies BallegeerSofie DesmetJonathan ThommisLode De CauwerSam Lievens et al.

A1 Journal Article in SCIENTIFIC REPORTS

IL-1β AcTaleukins : towards potent yet safe adjuvants for tumor vaccination

Bram Van Den EeckhoutElianne BurgAnje CauwelsFrank PeelmanSandra Van LintJan TavernierSarah Gerlo

Leptin receptor antagonism of iNKT cell function : a novel strategy to combat multiple myeloma

Mérédis FavreauE MenuDjoere GaublommeK VanderkerkenS FaictK MaesE De BruyneSrinath GovindarajanMichael DrennanSerge Van Calenbergh et al.

A1 Journal Article in LEUKEMIA

MAPPI-DAT : data management and analysis for protein-protein interaction data from the high-throughput MAPPIT cell microarray platform

Surya GuptaVeronic De PuysseleyrJosé Van Der HeydenDavy MaddeleinIrma LemmensSam LievensSven DegroeveJan TavernierLennart Martens

A1 Journal Article in BIOINFORMATICS

Novel technologies for the analysis of protein complexes

Kevin TitecaJan TavernierSven Eyckerman

Protein complex analysis : from raw protein lists to protein interaction networks

Pieter MeysmanKevin TitecaSven EyckermanJan TavernierBart GoethalsLennart MartensDirk ValkenborgKris Laukens

A1 Journal Article in MASS SPECTROMETRY REVIEWS

RNF41 interacts with the VPS52 subunit of the GARP and EARP complexes

Delphine MasschaeleLeentje De CeuninckJoris WaumanDieter DefeverFrank StennerSam LievensFrank PeelmanJan Tavernier

A1 Journal Article in PLOS ONE

Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma

Kenneth VerstraeteFrank PeelmanHarald BraunJuan LopezDries Van RompaeyAnn DansercoerIsabel VandenbergheKris PauwelsJan TavernierBart Lambrecht et al.

A1 Journal Article in NATURE COMMUNICATIONS

TYK2-induced phosphorylation of Y640 suppresses STAT3 transcriptional activity

Raffaele MoriJoris WaumanLaura IcardiJosé Van Der HeydenLode De CauwerFrank PeelmanKarolien De BosscherJan Tavernier

A1 Journal Article in SCIENTIFIC REPORTS

The ER stress sensor PERK coordinates ER-plasma membrane contact site formation through interaction with filamin-A and F-actin remodeling

Alexander R van VlietFrancesca GiordanoSarah GerloInmaculada SeguraSofie Van EygenGeert MolenberghsSusana RochaAudrey HoucineRita DeruaTom Verfaillie et al.

A1 Journal Article in MOLECULAR CELL

The Prader-Willi syndrome proteins MAGEL2 and necdin regulate leptin receptor cell surface abundance through ubiquitination pathways

Tishani Methsala WijesuriyaLeentje De CeuninckDelphine MasschaeleMatthea R SandersonKarin Vanessa CariasJan TavernierRachel Wevrick

A1 Journal Article in HUMAN MOLECULAR GENETICS

The leptin receptor complex : heavier than expected?

Joris WaumanLennart ZabeauJan Tavernier

A1 Journal Article in FRONTIERS IN ENDOCRINOLOGY

Theranostic radiolabeled anti-CD20 sdAb for targeted radionuclide therapy of non-Hodgkin lymphoma

Ahmet KrasniqiMatthias D'HuyvetterCatarina XavierKevin Van der JeughtSerge MuyldermansJosé Van Der HeydenTony LahoutteJan TavernierNick Devoogdt

A1 Journal Article in MOLECULAR CANCER THERAPEUTICS

Unbiased protein association study on the public human proteome reveals biological connections between co-occurring protein pairs

Surya GuptaKenneth VerheggenJan TavernierLennart Martens

A1 Journal Article in JOURNAL OF PROTEOME RESEARCH

sfinx : an R package for the elimination of false positives from affinity purification-mass spectrometry datasets

Kevin TitecaPieter MeysmanKris LaukensLennart MartensJan TavernierSven Eyckerman

A1 Journal Article in BIOINFORMATICS

2016

A combined binary interaction and phenotypic map of C. elegans cell polarity proteins

Thijs KoormanDiana KlompstraMonique van der VoetIrma LemmensJoão J RamalhoSusan NieuwenhuizeSander van den HeuvelJan TavernierJeremy NanceMike Boxem

A1 Journal Article in NATURE CELL BIOLOGY

An omics strategy to unravel the role of the β2-adrenergic receptor in inflammation

Sarah GerloGuy LaureysKrzysztof KolmusSven EyckermanKris GevaertIrma LemmensJan Tavernier

Chemical dimerizers in three-hybrid systems for small molecule-target protein profiling

Dries De ClercqJan TavernierSam LievensSerge Van Calenbergh

A1 Journal Article in ACS CHEMICAL BIOLOGY

Chromatin recruitment of activated AMPK drives fasting response genes co-controlled by GR and PPARα

Dariusz RatmanViacheslav MylkaNadia BougarneMichal PawlakSandrine CaronNathalie HennuyerRéjane PaumelleLode De CauwerJonathan ThommisMark H Rider et al.

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Hyperleptinemia is associated with impaired pulmonary host defense

Niki DJ UbagsRenee D StapletonJuanita H.J. VernooyElianne BurgJenna BementCatherine M HayesSebastian VentroneLennart ZabeauJan TavernierMatthew E Poynter et al.

A1 Journal Article in JCI INSIGHT

Identification and functional analysis of molecular interaction partners of δ-protocadherin family members with putative roles in cancer

Eleonora BilliFrans Van RoyJan Tavernier

Intelligent mixing of proteomes for elimination of false positives in affinity purification-mass spectrometry

Sven EyckermanFrancis ImpensEmmy Van QuickelbergheNoortje SamynGiel VandemoorteleDelphine De SutterJan TavernierKris Gevaert

A1 Journal Article in JOURNAL OF PROTEOME RESEARCH

JAK2 deficiency as a novel cause of impaired Th17 immunity

FILOMEEN HAERYNCKDelfien BogaertElfride De BaereKristof Van SchilFrauke CoppietersMarieke De BruyneMargot HagendorensTessa KerreFrans De BaetsVictoria Bordon Maria et al.

Lenalidomide stabilizes the erythropoietin receptor by inhibiting the E3 ubiquitin ligase RNF41

Ashley A BasiorkaKathy L McGrawLeentje De CeuninckLori N GrinerLing ZhangJustine A ClarkGisela CaceresLubomir SokolRami S KomrokjiGary W Reuther et al.

A1 Journal Article in CANCER RESEARCH

Modulation of protein-protein interactions for the development of novel therapeutics

Ioanna PettaSam LievensClaude LibertJan TavernierKarolien De Bosscher

A1 Journal Article in MOLECULAR THERAPY

OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination

Maria Francesca BaiettiMichal SimicekLayka Abbasi AsbaghEnrico RadaelliSam LievensJonathan CrowtherMikhail SteklovVasily N AushevDavid Martínez GarcíaJan Tavernier et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

Proteome-scale binary interactomics in human cells

Sam LievensJosé Van Der HeydenDelphine MasschaeleLeentje De CeuninckIoanna PettaSurya GuptaVeronic De PuysseleyrVirginie VauthierIrma LemmensDries De Clercq et al.

A1 Journal Article in MOLECULAR & CELLULAR PROTEOMICS

Reconstructing the TIR side of the myddosome: a paradigm for TIR-TIR interactions

Laurens VynckeCelia BovijnEwald PauwelsTim Van AckerElien RuyssinckElianne BurgJan TavernierFrank Peelman

A1 Journal Article in STRUCTURE

SFINX : straightforward filtering index for affinity purification mass spectrometry data analysis

Kevin TitecaPieter MeysmanKris GevaertJan TavernierKris LaukensLennart MartensSven Eyckerman

A1 Journal Article in JOURNAL OF PROTEOME RESEARCH

Synthesis of chemical dimerizers for the optimization of MASPIT

Dries De ClercqSerge Van CalenberghJan TavernierSam Lievens

The interactome of the glucocorticoid receptor and its influence on the actions of glucocorticoids in combatting inflammatory and infectious diseases

Ioanna PettaLien DejagerMarlies BallegeerSam LievensJan TavernierKarolien De BosscherClaude Libert

A2 Journal Article in MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Trapping mammalian protein complexes in viral particles

Sven EyckermanKevin TitecaEmmy Van QuickelbergheEva ClootsAnnick VerheeNoortje SamynLeentje De CeuninckEvy TimmermanDelphine De SutterSam Lievens et al.

A1 Journal Article in NATURE COMMUNICATIONS

Ubiquitin D regulates IRE1 α/c-Jun N-terminal kinase (JNK) protein-dependent apoptosis in pancreatic beta cells

Flora BrozziSarah GerloFabio Arturo GriecoMatilda JuusolaAlexander BalhuizenSam LievensConny GysemansMarco BuglianiChantal MathieuPiero Marchetti et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2015

Adrenergic regulation of Interleukin-6 and chemokine expression : stressing NF-κB

Sarah GerloGuy LaureysAnneleen SpoorenKrzysztof KolmusJacques De KeyserJoeri AertsJan Tavernier

Alternative reagents for methotrexate as immobilizing anchor moieties in the optimization of MASPIT: synthesis and biological evaluation

Dries De ClercqMartijn RisseeuwIzet KaralicAnne-Sophie De SmetDieter DefeverJan TavernierSam LievensSerge Van Calenbergh

A1 Journal Article in CHEMBIOCHEM

An abnormally glycosylated isoform of erythropoietin in hemangioblastoma is associated with polycythemia

Sigurd E DelangheJan DierickThomas MaenhoutLennart ZabeauJan TavernierKathleen ClaesJoris BleyenJoris Delanghe

A1 Journal Article in CLINICA CHIMICA ACTA

An interactomics approach to unravel IRE1α function

Sarah GerloSam LievensElien RuyssinckDieter DefeverHannes DemaréJan Tavernier

Constitutive membrane binding of the multi-site docking protein Gab1 in JAK2-V617F expressing cells

Hannes BongartzWiebke HessenkemperAlexandra WolfRene EulenfeldPhilip C SimisterIris BehrmannJan TavernierStephan M FellerClaude HaanFred Schaper

High efficiency targeting of IFN-α activity: possible applications in fighting tumours and infections

Gilles UzéJan Tavernier

A1 Journal Article in CYTOKINE & GROWTH FACTOR REVIEWS

Identification of striatin-3 and ZBTB32 as two novel modulators of glucocorticoid receptor activity

Ioanna PettaClaude LibertJan Tavernier

Leptin's metabolic and immune functions can be uncoupled at the ligand/receptor interaction level

Lennart ZabeauCathy J JensenSylvie SeeuwsKoen VenkenAnnick VerheeDominiek CatteeuwGeert van LooHui ChenKen WalderJacob Hollis et al.

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Leptin: from structural insights to the design of antagonists

Lennart ZabeauFrank PeelmanJan Tavernier

A1 Journal Article in LIFE SCIENCES

MAPK-induced Gab1 translocation to the plasma membrane depends on a regulated intramolecular switch

Alexandra WolfRené EulenfeldHannes BongartzWiebke HessenkemperPhilip C SimisterSam LievensJan TavernierStephan M FellerFred Schaper

A1 Journal Article in CELLULAR SIGNALLING

Reconstructing the TIR side of the Myddosome: a paradigm for TIR-TIR interactions?

Laurens VynckeCelia BovijnEwald PauwelsTim Van AckerElien RuyssinckJan TavernierFrank Peelman

Ryanodine receptors are targeted by anti-apoptotic Bcl-X-L involving its BH4 domain and Lys87 from its BH3 domain

Tim VervlietIrma LemmensElien VandermarliereElke DecrockHristina IvanovaGiovanni MonacoVincenzo SorrentinoNael Nadif KasriLudwig MissiaenLennart Martens et al.

A1 Journal Article in SCIENTIFIC REPORTS

Small molecule fusion compounds for the optimization of MASPIT, a high throughput three-hybrid target deconvolution assay

Dries De ClercqSam LievensMartijn RisseeuwJan TavernierSerge Van Calenbergh

Spatiotemporal 16p11.2 protein network implicates cortical late mid-fetal brain development and KCTD13-Cul3-RhoA pathway in psychiatric diseases

Guan Ning LinRoser CorominasIrma LemmensXinping YangJan TavernierDavid E HillMarc VidalJonathan SebatLilia M Iakoucheva

A1 Journal Article in NEURON

Synthesis and biological evaluation of small-molecule fusion compounds for the optimization of MASPIT, a three-hybrid target deconvolution assay

Dries De ClercqSam LievensMartijn RisseeuwJan TavernierSerge Van Calenbergh

The transcriptional co-regulation of hepatic lipid metabolism by GR and PPARα

Dariusz RatmanKarolien De BosscherJan Tavernier

β₂-Adrenergic receptors in immunity and inflammation: stressing NF-κB

Krzysztof KolmusJan TavernierSarah Gerlo

A1 Journal Article in BRAIN BEHAVIOR AND IMMUNITY

2014

20 Years of leptin: insights into signaling assemblies of the leptin receptor

Frank PeelmanLennart ZabeauKedar MoharanaSavvas SavvidesJan Tavernier

A1 Journal Article in JOURNAL OF ENDOCRINOLOGY

A bidirectional crosstalk between iNKT cells and adipocytes mediated by leptin modulates susceptibility for T cell mediated hepatitis

Koen VenkenSylvie SeeuwsLennart ZabeauPeggy JacquesTine DecruyJulie CoudenysEveline VerheugenFien WindelsDominiek CatteeuwMichael Drennan et al.

A1 Journal Article in JOURNAL OF HEPATOLOGY

A combined 'omics' approach identifies N-Myc interactor as a novel cytokine-induced regulator of IRE1α protein and c-Jun N-terminal kinase in pancreatic beta cells

Flora BrozziSarah GerloFabio Arturo GriecoTarlliza Romanna NardelliSam LievensConny GysemansLorella MarselliPiero MarchettiChantal MathieuJan Tavernier et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

A combined 'omics' approach identifies NMI as a novel cytokine-induced regulator of IRE1 alpha and JNK in pancreatic beta cells

F BrozziSarah GerloFA GriecoSam LievensC GysemansL MarselliP MarchettiC MathieuJan TavernierDL Eizirik

A proteome-scale map of the human interactome network

Thomas RollandMurat TaşanBenoit CharloteauxSamuel J PevznerQuan ZhongNidhi SahniSong YiIrma LemmensCelia FontanilloRoberto Mosca et al.

A1 Journal Article in CELL

An interactomics approach to unravel IRE1α function

Sarah GerloSam LievensElien RuyssinckDieter DefeverHannes DemaréJan Tavernier

Antagonizing leptin: current status and future directions

Lennart ZabeauFrank PeelmanJan Tavernier

A1 Journal Article in BIOLOGICAL CHEMISTRY

Design, synthesis and biological evaluation of tamoxifen-fusion compounds for the optimization of MASPIT, a three-hybrid target deconvolution assay

Dries De ClercqMartijn RisseeuwSam LievensJan TavernierSerge Van Calenbergh

Genome dynamics of the human embryonic kidney 293 lineage in response to cell biology manipulations

Yao-Cheng LinMorgane BooneLeander MeurisIrma LemmensNadine Van RoyArne SoeteJoke ReumersMatthieu MoisseStéphane PlaisanceRadoje Drmanac et al.

A1 Journal Article in NATURE COMMUNICATIONS

Getting RIDD of RNA: IRE1 in cell fate regulation

Marion MaurelE ChevetJan TavernierSarah Gerlo

A1 Journal Article in TRENDS IN BIOCHEMICAL SCIENCES

High efficiency cell-specific targeting of cytokine activity

Geneviève GarcinFranciane PaulMarkus StaufenbielYann BordatJosé Van Der HeydenStephan WilmesGuillaume CartronFlorence ApparaillyStefaan De KokerJacob Piehler et al.

A1 Journal Article in NATURE COMMUNICATIONS

Inhibition of the connexin 43 elevation may be involved in the neuroprotective activity of leptin against brain ischemic injury

Zi-Hui DengJie LiaoJin-Ying ZhangChen LiangCui-Hong SongMing HanLu-Huan WangHui XueKai ZhangLennart Zabeau et al.

A1 Journal Article in CELLULAR AND MOLECULAR NEUROBIOLOGY

Kinase Substrate Sensor (KISS), a mammalian in situ protein interaction sensor

Sam LievensSarah GerloIrma LemmensDries De ClercqMartijn RisseeuwNele VanderroostAnne-Sophie De SmetElien RuyssinckEric ChevetSerge Van Calenbergh et al.

A1 Journal Article in MOLECULAR & CELLULAR PROTEOMICS

Kinetics of leptin binding to the Q223R leptin receptor

Hans VerkerkeCaitlin NaylorLennart ZabeauJan TavernierWilliam A, Jr PetriChelsea Marie

A1 Journal Article in PLOS ONE

Mechanistic paradigm of leptin receptor activation revealed by complexes with wild type and antagonist leptins

Kedar MoharanaSavvas SavvidesJan Tavernier

Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism

Roser CorominasXinping YangGuan Ning LinShuli KangYun ShenLila GhamsariMartin BrolyMaria RodriguezStanley TamShelly A Trigg et al.

A1 Journal Article in NATURE COMMUNICATIONS

Selective modulation of the glucocorticoid receptor can distinguish between transrepression of NF-κB and AP-1

Karolien De BosscherIlse BeckLien DejagerNadia BougarneAnthoula GaigneauxSebastien ChateauvieuxDariusz RatmanMarc BrackeJan TavernierWim Vanden Berghe et al.

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Structural and mechanistic paradigm of leptin receptor activation revealed by complexes with wild-type and antagonist leptins

Kedar MoharanaLennart ZabeauFrank PeelmanPhilippe RinglerHenning StahlbergJan TavernierSavvas Savvides

A1 Journal Article in STRUCTURE

Structural basis of the proinflammatory signaling complex mediated by TSLP

Kenneth VerstraeteLoes van SchieLaurens VynckeYehudi BlochJan TavernierEwald PauwelsFrank PeelmanSavvas Savvides

A1 Journal Article in NATURE STRUCTURAL & MOLECULAR BIOLOGY

Study of crosstalk between G-protein coupled receptor-mediated signals and the Nuclear Factor-κB signal transduction cascade

Krzysztof KolmusSarah GerloJan Tavernier

Synthesis and biological evaluation of tamoxifen fusion compounds for the optimization of MASPIT, a three-hybrid target deconvolution assay

Dries De ClercqMartijn RisseeuwSam LievensJan TavernierSerge Van Calenbergh

The anti-tumor activity of a neutralizing nanobody targeting leptin receptor in a mouse model of melanoma

Travis McMurphyRun XiaoDaniel MageeAndrew SlaterLennart ZabeauJan TavernierLei Cao

A1 Journal Article in PLOS ONE

The increasing complexity of glucocorticoid receptor signaling and regulation

Sofie DesmetIlse BeckNadia BougarneDorien ClarisseJulie DeckersDariusz RatmanJan TavernierKarolien De Bosscher

A2 Journal Article in PROCEEDINGS OF THE BELGIAN ROYAL ACADEMIES OF MEDICINE

The role of leptin in the development of pulmonary neutrophilia in infection and acute lung injury

Niki D UbagsJuanita H VernooyElianne BurgCatherine HayesJenna BementEstee DilliLennart ZabeauEdward AbrahamKatie R PochJerry A Nick et al.

A1 Journal Article in CRITICAL CARE MEDICINE

The small GTPase Arf6 is essential for TLR4 signaling in multiple (path)ways

Tim Van AckerFrank PeelmanJan Tavernier

The small GTPase Arf6 is essential for the Tram/Trif pathway in RLR4 signaling

Tim Van AckerSven EyckermanLieselotte Vande WalleSarah GerloMarc GoethalsMohamed LamkanfiCelia BovijnJan TavernierFrank Peelman

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

β-Agonists selectively modulate proinflammatory gene expression in skeletal muscle cells via non-canonical nuclear crosstalk mechanisms

Krzysztof KolmusMarleen Van TroysKarlien Van WesemaelChristophe AmpeGuy HaegemanJan TavernierSarah Gerlo

A1 Journal Article in PLOS ONE

2013

A 'clickable' MTX-reagent as a practical tool for profiling small molecule-intracellular target interactions via MASPIT

Martijn RisseeuwDries De ClercqSam LievensUlrik HillaertDavy SinnaeveFreya Van den BroeckJosé MartinsJan TavernierSerge Van Calenbergh

A1 Journal Article in CHEMMEDCHEM

Compound A, a selective glucocorticoid receptor modulator, enhances heat shock protein Hsp70 gene promoter activation

Ilse BeckZuzanna DrebertRuben Hoya-AriasAli A BaharMichael DevosDorien ClarisseSofie DesmetNadia BougarneBart RuttensValerie Gossye et al.

A1 Journal Article in PLOS ONE

High efficiency targeting of interferon α activity

Geneviève GarcinFranciane PaulMarkus StaufenbielYann BordatJosé Van Der HeydenStephan WilmesGuillaume CartronFlorence ApparaillyStefaan De KokerJacob Piehler et al.

How glucocorticoid receptors modulate the activity of other transcription factors: a scope beyond tethering

Dariusz RatmanWim Vanden BergheLien DejagerClaude LibertJan TavernierIlse BeckKarolien De Bosscher

A1 Journal Article in MOLECULAR AND CELLULAR ENDOCRINOLOGY

Identification of binding sites for myeloid differentiation primary response gene 88 (MyD88) and Toll-like receptor 4 in MyD88 adapter-like (Mal)

Celia BovijnAnn-Sophie DesmetIsabel UyttendaeleTim Van AckerJan TavernierFrank Peelman

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Leptin as regulator of pulmonary immune responses: involvement in respiratory diseases

Juanita HJ VernooyNiki DJ UbagsGuy BrusselleJan TavernierBenjamin T SurattGuy JoosEmiel FM WoutersKen Bracke

A1 Journal Article in PULMONARY PHARMACOLOGY & THERAPEUTICS

Leptin attenuates lipopolysaccharide-induced apoptosis of thymocytes partially via down-regulation of cPLA2 and p38 MAPK activation

Chen LiangJie LiaoZihui DengCuihong SongJinying ZhangLennart ZabeauJan TavernierKai ZhangHui XueGuangtao Yan

A1 Journal Article in INTERNATIONAL IMMUNOPHARMACOLOGY

MAPPIT and Co: the importance of system artifacts

Jan TavernierLeentje De CeuninckSarah GerloIrma LemmensSam LievensJosé Van Der HeydenJoris Wauman

RNF41 is a key regulator of cytokine receptor trafficking and signaling

Leentje De CeuninckJan Tavernier

Reciprocal cross-regulation between RNF41 and USP8 controls cytokine receptor sorting and processing

Leentje De CeuninckJoris WaumanDelphine MasschaeleFrank PeelmanJan Tavernier

A1 Journal Article in JOURNAL OF CELL SCIENCE

Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury

Nan WangElke De VuystRaf PonsaertsKerstin BoenglerNicolás Palacios-PradoJoris WaumanCharles P LaiMarijke De BockElke DecrockMélissa Bol et al.

A1 Journal Article in BASIC RESEARCH IN CARDIOLOGY

Syntheses of MTX-fusion compounds for target profiling of small molecules with MASPIT

Dries De ClercqMartijn RisseeuwSam LievensJan TavernierSerge Van Calenbergh

The Sin3a repressor complex regulates the balance between the activities of different STAT proteins

Laura IcardiRaffaele MoriViola GesellchenSven EyckermanJudith VerhelstKoen VercauterenXavier SaelensPhilip MeulemanKarolien De BosscherM Boutros et al.

The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response

Michal SimicekSam LievensMathias LagaDmytro GuzenkoVasily N AushevPeter KalevMaria Francesca BaiettiSergei V StrelkovKris GevaertJan Tavernier et al.

A1 Journal Article in NATURE CELL BIOLOGY

Using KISS mammalian two-hybrid technology to study IRE1α function

Sarah GerloSam LievensElien RuyssinckHannes DemaréDieter DefeverJan Tavernier

2012

A dissociated glucocorticoid receptor modulator reduces airway hyperresponsiveness and inflammation in a mouse model of asthma

Laurent L ReberFrançois DaubeufMaud PlantingaLode De CauwerSarah GerloWim WaelputSerge Van CalenberghJan TavernierGuy HaegemanBart Lambrecht et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

ArrayMAPPIT: a screening platform for human protein interactome analysis

Sam LievensNele VanderroostDieter DefeverJosé Van Der HeydenJan Tavernier

Bookchapter in Two hybrid technologies : methods and protocols

Biologically active, magnICON®-expressed EPO-Fc from stably transformed Nicotiana benthamiana plants presenting tetra-antennary N-glycan structures

Bieke NagelsEls Van DammeNico CallewaertLennart ZabeauJan TavernierJoris DelangheAnnemie BoetsAlexandra CastilhoKoen Weterings

A1 Journal Article in JOURNAL OF BIOTECHNOLOGY

Diversity in genetic in vivo methods for protein-protein interaction studies: from the yeast two-hybrid system to the mammalian split-luciferase system

Bram StynenHélène TournuJan TavernierPatrick Van Dijck

A1 Journal Article in MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses

Nicolas SimonisJean-François RualIrma LemmensMathieu BoxusTomoko Hirozane-KishikawaJean-Stéphane GatotAmélie DricotTong HaoDidier VertommenSébastien Legros et al.

A1 Journal Article in RETROVIROLOGY

Identification of interaction sites for dimerization and adapter recruitment in Toll/interleukin-1 receptor (TIR) domain of Toll-like receptor 4

Celia BovijnPeter UlrichtsAnne-Sophie De SmetDominiek CatteeuwRudi BeyaertJan TavernierFrank Peelman

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of protein-protein interaction sites in the TLR4/Mal/MyD88 complex

Celia BovijnFrank PeelmanJan Tavernier

MAPPIT analysis of medically relevant protein-protein interactions

Isabel UyttendaeleJan TavernierFrank Peelman

MAPPIT as a high-throughput screening assay for modulators of protein-protein interactions in HIV and HCV

Bertrand Van SchoubroeckKoen Van AckerGéry DamsDirk JochmansReginald ClaytonJan Martin BerkeSam LievensJosé Van Der HeydenJan Tavernier

Bookchapter in Two hybrid technologies : methods and protocols

MASPIT: a high throughput assay for the identification of cytosolic targets of small molecules : proof of principle

Martijn RisseeuwSam LievensDries De ClercqUlrik HillaertJan TavernierSerge Van Calenbergh

Opposed regulation of type I IFN-induced STAT3 and ISGF3 transcriptional activities by histone deacetylases (HDACS) 1 and 2

Laura IcardiSam LievensRaffaele MoriJulie PiessevauxLode De CauwerKarolien De BosscherJan Tavernier

A1 Journal Article in FASEB JOURNAL

Protein-protein interactions: network analysis and applications in drug discovery

Jennyfer BultinckSam LievensJan Tavernier

A1 Journal Article in CURRENT PHARMACEUTICAL DESIGN

Random mutagenesis MAPPIT analysis identifies binding sites for Vif and Gag in both cytidine deaminase domains of Apobec3G

Isabel UyttendaeleDelphine LavensDominiek CatteeuwIrma LemmensCelia BovijnJan TavernierFrank Peelman

A1 Journal Article in PLoS ONE

Selection of non-competitive leptin antagonists using a random nanobody-based approach

Lennart ZabeauAnnick VerheeDominiek CatteeuwLiesbeth FaesSylvie SeeuwsTine DecruyDirk ElewautFrank PeelmanJan Tavernier

A1 Journal Article in BIOCHEMICAL JOURNAL

Syntheses of methotrexate-hybrid compounds for target profiling of small molecules with MASPIT

Dries De ClercqMartijn RisseeuwSam LievensJan TavernierSerge Van Calenbergh

Syntheses of methotrexate-hybrid compounds for target profiling of small molecules with MASPIT

Dries De ClercqMartijn RisseeuwSam LievensJan TavernierSerge Van Calenbergh

Syntheses of methotrexate-hybrid compounds for target profiling of small molecules with MASPIT

Dries De ClercqMartijn RisseeuwSam LievensJan TavernierSerge Van Calenbergh

The HAT/HDAC interplay: multilevel control of STAT signaling

Laura IcardiKarolien De BosscherJan Tavernier

A1 Journal Article in CYTOKINE & GROWTH FACTOR REVIEWS

The Sin3a repressor complex is a master regulator of STAT transcriptional activity

Laura IcardiRaffaele MoriViola GesellchenSven EyckermanLode De CauwerJudith VerhelstKoen VercauterenXavier SaelensPhilip MeulemanGeert Leroux-Roels et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The importance of acetylation for STAT signaling

Laura IcardiJan Tavernier

The use of mammalian two-hybrid technologies for high-throughput drug screening

Sam LievensMaureen CaligiuriNiko KleyJan Tavernier

A1 Journal Article in METHODS

2011

A protein engineering approach differentiates the functional importance of carbohydrate moieties of interleukin-5 receptor α

Tetsuya IshinoNicoleta J EconomouKaryn McFaddenMeirav Zaks-ZilbermanMonika JostSabine BaxterMark R ContarinoAdrian E HarringtonPatrick J LollGianfranco Pasut et al.

A1 Journal Article in BIOCHEMISTRY

Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumors

Nicolas F DelahayeSylvie RusakiewiczIsabelle MartinsCedric MenardStephan RouxLuc LyonnetPascale PaulMatthieu SarabiNathalie ChaputMichaela Semeraro et al.

A1 Journal Article in NATURE MEDICINE

CD248 facilitates tumor growth via its cytoplasmic domain

Margarida MaiaAstrid DeVrieseTom JanssensMichael MoonsRik J LoriesJan TavernierEdward M Conway

A1 Journal Article in BMC CANCER

Chylomicron formation and glucagon-like peptide 1 receptor are involved in activation of the nutritional anti-inflammatory pathway

Tim LubbersJacco J de HaanM'hamed HadfouneLennart ZabeauJan TavernierYiren ZhangDavid GrundyJan Willem M GreveWim A Buurman

A1 Journal Article in JOURNAL OF NUTRITIONAL BIOCHEMISTRY

HAb18G/CD147 Promotes cell motility by regulating annexin II-activated RhoA and Rac1 signaling pathways in hepatocellular carcinoma cells

Pu ZhaoWei ZhangShi-Jie WangXiao-Ling YuJuan TangWan HuangYong LiHong-Yong CuiYun-Shan GuoJan Tavernier et al.

A1 Journal Article in HEPATOLOGY

Leptin receptor signaling: pathways to leptin resistance

Joris WaumanJan Tavernier

A1 Journal Article in FRONTIERS IN BIOSCIENCE-LANDMARK

MAPPIT: a protein interaction toolbox built on insights in cytokine receptor signaling

Sam LievensFrank PeelmanKarolien De BosscherIrma LemmensJan Tavernier

A1 Journal Article in CYTOKINE & GROWTH FACTOR REVIEWS

New insights in the involvement of leptin and NKT cells in autoimmune responses

Sylvie SeeuwsDirk ElewautJan Tavernier

Novel insights in leptin receptor signaling, shedding and clipping

Joris WaumanJan Tavernier

Opposite regulation of type I IFN-induced STAT3 and ISGF3 transcriptional activities by histone deacetylases (HDACS) 1 and 2

Laura IcardiKarolien De BosscherRaffaele MoriLode De CauwerSam LievensJan Tavernier

Peroxiredoxin-controlled G-CSF signalling at the endoplasmic reticulum-early endosome interface

Karishma PalandeOnno RooversJudith GitsCarola VerwijmerenYoshihito IuchiJunichi FujiiBenjamin G NeelRobert KarischJan TavernierIvo P Touw

A1 Journal Article in JOURNAL OF CELL SCIENCE

RNF41 (Nrdp1) controls type 1 cytokine receptor degradation and ectodomain shedding

Joris WaumanLeentje De CeuninckNele VanderroostSam LievensJan Tavernier

A1 Journal Article in JOURNAL OF CELL SCIENCE

STAT3 transcriptional activity is controlled by regulated acetylation

Jan TavernierLaura IcardiViola GesellchenRaffaele MoriSam LievensSven EyckermanJennyfer BultinckM BoutrosKarolien De Bosscher

2010

Abrogation of the Brd4-positive transcription elongation factor b complex by Papillomavirus E2 protein contributes to viral oncogene repression

JunPeng YanQing LiSam LievensJan TavernierJianXin You

A1 Journal Article in JOURNAL OF VIROLOGY

CD248 and its cytoplasmic domain: a therapeutic target for Arthritis

Margarida MaiaAstrid de VrieseTom JanssensMichael MoonsKristel Van LanduytJan TavernierRik J LoriesEduard M Conway

A1 Journal Article in ARTHRITIS AND RHEUMATISM

Caspase-1 targets the TLR adaptor Mal at a crucial TIR-domain interaction site

Peter UlrichtsCelia BovijnSam LievensRudi BeyaertJan TavernierFrank Peelman

A1 Journal Article in JOURNAL OF CELL SCIENCE

Definition of the interacting interfaces of Apobec3G and HIV-1 Vif using MAPPIT mutagenesis analysis

Delphine LavensFrank PeelmanJosé Van Der HeydenIsabel UyttendaeleDominiek CatteeuwAnnick VerheeB Van SchoubroeckJ KurthS HallenbergerR Clayton et al.

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Definition of the interacting interfaces of Apobec3G and HIV-1 Vif using MAPPIT mutagenesis analysis

Delphine LavensFrank PeelmanJosé Van Der HeydenIsabel UyttendaeleDominiek CatteeuwBertrand Van SchouwbroeckJulia KurthSabine HallenbergerReginald ClaytonJan Tavernier

Large-scale protein interactome mapping: strategies and opportunities

Sam LievensSven EyckermanIrma LemmensJan Tavernier

A1 Journal Article in EXPERT REVIEW OF PROTEOMICS

Leptin modulates innate and adaptive immune cell recruitment after cigarette smoke exposure in mice

JHJ VernooyKen BrackeNEA DrummenNSA PauwelsLennart ZabeauRJ van SuylenJan TavernierGuy JoosEFM WoutersGuy Brusselle

A1 Journal Article in JOURNAL OF IMMUNOLOGY

New insights into the control of cytokine receptor degradation and ectodomain shedding

Jan TavernierLeentje De CeuninckJoris Wauman

Strategies towards high-quality binary protein interactome maps

Irma LemmensSam LievensJan Tavernier

A1 Journal Article in JOURNAL OF PROTEOMICS

2009

An empirical framework for binary interactome mapping

Kavitha VenkatesanJean-Francois RualAlexei VazquezUlrich StelzlIrma LemmensTomoko Hirozane-KishikawaTong HaoMartina ZenknerXiaofeng XinKwang-Il Goh et al.

A1 Journal Article in NATURE METHODS

An experimentally derived confidence score for binary protein-protein interactions

Pascal BraunMurat TasanMatija DrezeMiriam Barrios-RodilesIrma LemmensHaiyuan YuJulie M. SahalieRyan R. MurrayLuba RoncariAnne-Sophie De Smet et al.

A1 Journal Article in NATURE METHODS

Array MAPPIT: High-Throughput Interactome Analysis in Mammalian Cells

Sam LievensNele VanderroostJosé Van Der HeydenViola GesellchenMarc VidalJan Tavernier

A1 Journal Article in JOURNAL OF PROTEOME RESEARCH

Differential expression of the interleukin 5 receptor alpha isoforms in blood and tissue eosinophils of nasal polyp patients

Philippe GevaertC. HellmanL. LundbladJ. LundahlGabriële HoltappelsPaul Van CauwenbergeJan TavernierClaus Bachert

A1 Journal Article in ALLERGY

Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network

Nicolas SimonisJean-Francois RualAnne-Ruxandra CarvunisMurat TasanIrma LemmensTomoko Hirozane-KishikawaTong HaoJulie M. SahalieKavitha VenkatesanFana Gebreab et al.

A1 Journal Article in NATURE METHODS

MAPPIT (Mammalian Protein-Protein Interaction Trap) analysis of early steps in Toll-like receptor signalling

Peter UlrichtsIrma LemmensDelphine LavensRudi BeyaertJan Tavernier

Bookchapter in Toll-like receptors : methods and protocols

Mammalian two-hybrids come of age

Sam LievensIrma LemmensJan Tavernier

A1 Journal Article in TRENDS IN BIOCHEMICAL SCIENCES

New Activation Modus of STAT3 A TYROSINE-LESS REGION OF THE INTERLEUKIN-22 RECEPTOR RECRUITS STAT3 BY INTERACTING WITH ITS COILED-COIL DOMAIN

L DumoutierC de MeesterJan TavernierJC Renauld

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2008

A protein domain-based interactome network for C. elegans early embryogenesis

Mike BoxemZoltan MaligaNiels KlitgordNa LiIrma LemmensMiyeko ManaLorenzo de LichterveldeJoram D MulDiederik van de PeutMaxime Devos et al.

A1 Journal Article in CELL

Elongin B/C recruitment regulates substrate binding by CIS

Julie PiessevauxLeentje De CeuninckDominiek CatteeuwFrank PeelmanJan Tavernier

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Evaluation of Digitally Encoded Layer-by-layer Coated Microparticles as Cell Carriers

Farzaneh FayazpourBart LucasRoosmarijn VandenbrouckeStefaan DerveauxJan TavernierSam LievensJo DemeesterStefaan De Smedt

A1 Journal Article in ADVANCED FUNCTIONAL MATERIALS

Functional characterization of naturally occurring pathogenic mutations in the human leptin receptor

Wendy KimberFrank PeelmanXavier PrieurTheresia WangensteenStephen O'RahillyJan TavernierI. Sadaf Farooq

A1 Journal Article in ENDOCRINOLOGY

High-quality binary protein interaction map of the yeast interactome network

HY YUP BRAUNMA YILDIRIMIrma LemmensK VENKATESANJ SAHALIET HIROZANE-KISHIKAWAF GEBREABN LIN SIMONIS et al.

A1 Journal Article in SCIENCE

HyperISGylation of old world monkey ISG15 in human cells

Els PattynAnnick VerheeIsabel UyttendaeleJulie PiessevauxEvy TimmermanKris GevaertJoël VandekerckhoveFrank PeelmanJan Tavernier

A1 Journal Article in PLOS ONE

Insulin receptor substrate 4 couples the leptin receptor to multiple signaling pathways

Joris WaumanAnne-Sophie De SmetDominiek CatteeuwD BELSHAMJan Tavernier

A1 Journal Article in MOLECULAR ENDOCRINOLOGY

MAPPIT (MAmmalian Protein-Protein Interaction Trap) as a tool to study HIV reverse transcriptase dimerization in intact human cells

Els PattynDelphine LavensJosé Van Der HeydenAnnick VerheeSam LievensIrma LemmensS HALLENBERGERD JOCHMANSJan Tavernier

A1 Journal Article in JOURNAL OF VIROLOGICAL METHODS

MAPPIT analysis of early Toll-like receptor signalling events

Peter UlrichtsJan Tavernier

A1 Journal Article in IMMUNOLOGY LETTERS

MAPPIT: a versatile tool to study cytokine receptor signalling

Irma LemmensSam LievensJan Tavernier

A1 Journal Article in BIOCHEMICAL SOCIETY TRANSACTIONS

Multiple roles for the SOCS box

Julie PiessevauxDelphine LavensFrank PeelmanJan Tavernier

SOCS proteins and cytokine signalling: the many faces of the SOCS box

Julie PiessevauxJan Tavernier

TLR-4, IL-1R and TNF-R signaling to NF-kappa B: variations on a common theme

Lynn VerstrepenTine BekaertTL CHAUJan TavernierA CHARIOTRudi Beyaert

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

The many faces of the SOCS box

Julie PiessevauxDelphine LavensFrank PeelmanJan Tavernier

A1 Journal Article in CYTOKINE & GROWTH FACTOR REVIEWS

2007

Identification and evaluation of protein-protein interactions involved in NF-kB signaling using MAPPIT technology

Lars VereeckeSam LievensJan TavernierGeert van LooMozes SzeRudi Beyaert

Leptin induces inflammation-related genes in RINm5F insulinoma cells

P HEKERMANJ ZEIDLERS KORFMACHERS BAMBERG-LEMPERH KNOBELSPIESLennart ZabeauJan TavernierW BECKER

A1 Journal Article in BMC MOLECULAR BIOLOGY

MAPPIT analysis of TLR adaptor complexes

Peter UlrichtsFrank PeelmanRudi BeyaertJan Tavernier

A1 Journal Article in FEBS LETTERS

Mammalian protein-protein interaction trap (MAPPIT) analysis of STAT5, CIS, and SOCS2 interactions with the growth hormone receptor

Isabel UyttendaeleIrma LemmensAnnick VerheeAnne-Sophie De SmetJoël VandekerckhoveDelphine LavensFrank PeelmanJan Tavernier

A1 Journal Article in MOLECULAR ENDOCRINOLOGY

Novel role of WD40 and SOCS box protein-2 in steady-state distribution of granulocyte colony-stimulating factor receptor and G-CSF-controlled proliferation and differentiation signaling

SJ ERKELANDLH AARTSM IRANDOUSTO ROOVERSA KLOMPM VALKHOFJ GITSSven EyckermanJan TavernierIP TOUW

A1 Journal Article in ONCOGENE

The C-terminus of CIS defines its interaction pattern

Delphine LavensPeter UlrichtsDominiek CatteeuwKris GevaertJoël VandekerckhoveFrank PeelmanSven EyckermanJan Tavernier

A1 Journal Article in BIOCHEMICAL JOURNAL

The MAPPIT toolbox: novel strategies to analyze molecular interactions in intact cells

Jan TavernierIrma LemmensSam Lievens

2006

A complex interaction pattern of CIS and SOCS2 with the leptin receptor

Delphine LavensTony MontoyeJulie PiessevauxLennart ZabeauJoël VandekerckhoveKris GevaertW BECKERSven EyckermanJan Tavernier

A1 Journal Article in JOURNAL OF CELL SCIENCE

A role for leptin in the systemic inflammatory response syndrome (SIRS) and in immune response: an update

Wim WaelputPeter BrouckaertDaniël BroekaertJan Tavernier

A1 Journal Article in CURRENT MEDICINAL CHEMISTRY

Analysis of leptin signalling in hematopoietic cells using an adapted MAPPIT strategy

Tony MontoyeJulie PiessevauxDelphine LavensJoris WaumanDominiek CatteeuwJoël VandekerckhoveIrma LemmensJan Tavernier

A1 Journal Article in FEBS LETTERS

Dissection of the interaction interface of the leptin/leptin receptor complex and insights into receptor activation

Hannes IserentantJan Tavernier

Functional cross-modulation between SOCS proteins can stimulate cytokine signaling

Julie PiessevauxDelphine LavensT MONTOYEJoris WaumanDominiek CatteeuwJoël VandekerckhoveD BELSHAMFrank PeelmanJan Tavernier

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

MASPIT: Three-hybrid trap for quantitative proteome fingerprinting of small molecule-protein interactions in mammalian cells

M CALIGIURIL MOLZQ LIUF KAPLANJP XUJZ MAJETIR RAMOS-KELSEYK MURTHISam LievensJan Tavernier et al.

A1 Journal Article in CHEMISTRY & BIOLOGY

Mapping of binding site III in the leptin receptor and modeling of a hexameric leptin center dot leptin receptor complex

Frank PeelmanHannes IserentantAnne-Sophie De SmetJoël VandekerckhoveLennart ZabeauJan Tavernier

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Nasal IL-5 levels determine the response to anti-IL-5 treatment in patients with nasal polyps

Philippe GevaertDoris Lang-LoidoltAndreas LacknerHeinz StammbergerHeribert StaudingerThibaut Van ZeleGabriële HoltappelsJan TavernierPaul Van CauwenbergeClaus Bachert

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Reverse MAPPIT detects disruptors of protein-protein interactions in human cells

Irma LemmensSam LievensSven EyckermanJan Tavernier

A1 Journal Article in NATURE PROTOCOLS

Review: negative regtilation of leptin receptor signalling

Delphine LavensJulie PiessevauxJan Tavernier

A1 Journal Article in EUROPEAN CYTOKINE NETWORK

Single protein complex visualization: Seeing is believing

Sam LievensJan Tavernier

Editorial material

Study of the signalling pathways of the erythropoietin and leptin receptor using MAPPIT

Tony MontoyeJan Tavernier

Techniques: New pharmacological perspectives for the leptin receptor

Frank PeelmanC COUTURIERJ DAMLennart ZabeauJan TavernierR JOCKERS

A1 Journal Article in TRENDS IN PHARMACOLOGICAL SCIENCES

Two-hybrid and its recent adaptations

Sam LievensIrma LemmensTony MontoyeSven EyckermanJan Tavernier

A2 Journal Article in DRUG DISCOVERY TODAY. TECHNOLOGIES

2005

A systematic scan of interactions with tyrosine motifs in the erythropoietin receptor using a mammalian 2-hybrid approach

Tony MontoyeIrma LemmensDominiek CatteeuwSven EyckermanJan Tavernier

A1 Journal Article in BLOOD

Immunostimulatory potential of hepatitis B nucleocapsid preparations: lipopolysaccharide contamination should not be overlooked

Peter VanlandschootFreya Van HouttePeter UlrichtsJan TavernierGeert Leroux-Roels

A1 Journal Article in JOURNAL OF GENERAL VIROLOGY

Leptin receptor activation depends on critical cysteine residues in its fibronectin type III subdomains

Lennart ZabeauD DEFEAUH ISERENTANTJoël VandekerckhoveFrank PeelmanJan Tavernier

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Leptin, immune responses and autoimmune disease. Perspectives on the use of leptin antagonists

Frank PeelmanHannes IserentantSven EyckermanLennart ZabeauJan Tavernier

A1 Journal Article in CURRENT PHARMACEUTICAL DESIGN

Mapping of the interface between leptin and the leptin receptor CRH2 domain

H ISERENTANTFrank PeelmanD DEFEAUJoël VandekerckhoveLennart ZabeauJan Tavernier

A1 Journal Article in JOURNAL OF CELL SCIENCE

Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines

P HEKERMANJ ZEIDLERS BAMBERG-LEMPERH KNOBELSPIESDelphine LavensJan TavernierHG JOOSTW BECKER

A1 Journal Article in FEBS JOURNAL

Reverse MAPPIT: screening for protein-protein interaction modifiers in mammalian cells

Sven EyckermanIrma LemmensDominiek CatteeuwAnnick VerheeJoël VandekerckhoveSam LievensJan Tavernier

A1 Journal Article in NATURE METHODS

2004

Design of a fluorescence-activated cell sorting-based Mammalian protein-protein interaction trap

Sam LievensJ HEYDENEls VertentenJean PlumJoël VandekerckhoveJan Tavernier

Bookchapter in Methods in molecular biology

Differential activation of signalling pathways by the intracellular tyrosines of the leptin receptor

W BECKERP HEKERMANJ ZEIDLERS BAMBERG-LEMPERJan TavernierHG JOOST

Functional analysis of leptin receptor activation using a Janus kinase/signal transducer and activator of transcription complementation assay

Lennart ZabeauDelphine DefeauJosé Van Der HeydenHannes IserentantJoël VandekerckhoveJan Tavernier

A1 Journal Article in MOLECULAR ENDOCRINOLOGY

Leptin: linking adipocyte metabolism with cardiovascular and autoimmune diseases

Frank PeelmanWim WaelputHannes IserentantDelphine LavensSven EyckermanLennart ZabeauJan Tavernier

A1 Journal Article in PROGRESS IN LIPID RESEARCH

Mapping of the leptin binding sites and design of a leptin antagonist

Frank PeelmanKatrien Van BenedenLennart ZabeauHannes IserentantPeter UlrichtsDelphine DefeauAnnick VerheeDominiek CatteeuwDirk ElewautJan Tavernier

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation by protein kinase CK2 modulates the activity of the ATP binding cassette A1 transporter

Stein RoosbeekFrank PeelmanAnnick VerheeChristine LabeurH CASTERMarc LensinkC CIRULLIJohan GrootenC COCHETJoël Vandekerckhove et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of the ABCA1 transporter activity by protein kinase CK2

R STEINFrank PeelmanJan TavernierMaryvonne Rosseneu

Role of intracellular tyrosine residues in the desensitisation of leptin receptor signal transduction

J ZEIDLERP HEKERMANJan TavernierW BECKER

Soluble interleukin-5 receptor alpha is increased in acute exacerbation of chronic obstructive pulmonary disease

G ROHDEPhilippe GevaertGabriële HoltappelsL FRANSENI BORGA WIETHEGEU ARINIAJan TavernierG SCHULTZE-WERNINGHAUSClaus Bachert

A1 Journal Article in INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

2003

Enhanced soluble interleukin-5 receptor alpha expression in nasal polyposis

Philippe GevaertClaus BachertGabriële HoltappelsClaudina Perez NovoJosé Van Der HeydenL FRANSENS DEPRAETEREH WALTERPaul Van CauwenbergeJan Tavernier

A1 Journal Article in ALLERGY

Heteromeric MAPPIT: a novel strategy to study modification-dependent protein-protein interactions in mammalian cells

Irma LemmensSven EyckermanLennart ZabeauDominiek CatteeuwEls VertentenK VERSCHUEREND HUYLEBROECKJoël VandekerckhoveJan Tavernier

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Interleukin 5, eosinophilic diseases and therapeutic intervention

Lennart ZabeauPhilippe GevaertClaus BachertJan Tavernier

A4 Journal Article in INFLAMMATION & ALLERGY : DRUG TARGETS

Structure and regulation of the ABCA transporters

Maryvonne RosseneuStein RoosbeekFrank PeelmanMarc LensinkJan Tavernier

The ins and outs of leptin receptor activation

Lennart ZabeauDelphine LavensFrank PeelmanSven EyckermanJoël VandekerckhoveJan Tavernier

A1 Journal Article in FEBS LETTERS

2002

A role for leptin in the systemic inflammatory response syndrome and immune response

Wim WaelputPeter BrouckaertDaniël BroekaertJan Tavernier

A4 Journal Article in INFLAMMATION & ALLERGY : DRUG TARGETS

Comparison of leptin- and interleukin-6-regulated expression of the rPAP gene family: evidence for differential co-regulatory signals

Daniël BroekaertSven EyckermanDelphine LavensAnnick VerheeWim WaelputJoël VandekerckhoveJan Tavernier

A1 Journal Article in EUROPEAN CYTOKINE NETWORK

Design and use of a mammalian protein-protein interaction trap (MAPPIT)

Sven EyckermanIrma LemmensSam LievensJ VAN DER HEYDENA VERHEEJoël VandekerckhoveJan Tavernier

A2 Journal Article in Science's signal transduction knowledge environment

MAPPIT: a cytokine receptor-based two-hybrid method in mammalian cells.

Jan TavernierSven EyckermanIrma LemmensJ VAN DER HEYDENJoël VandekerckhoveXaveer Van Ostade

A1 Journal Article in CLINICAL AND EXPERIMENTAL ALLERGY

Methods to map protein interactions in mammalian cells: different tools to address different questions.

Sven EyckermanJan Tavernier

A1 Journal Article in EUROPEAN CYTOKINE NETWORK

2001

A hydrophobic cluster at the surface of the human plasma phospholipid transfer protein is critical for activity on high density lipoproteins.

C DESRUMAUXChristine LabeurA VERHEEJan TavernierJoël VandekerckhoveMaryvonne RosseneuFrank Peelman

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

A mediator role for metallothionein in tumor necrosis factor-induced lethal shock

Wim WaelputDaniël BroekaertJoël VandekerckhovePeter BrouckaertJan TavernierClaude Libert

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Design and application of a cytokine-receptor-based interaction trap.

Sven EyckermanA VERHEEJ VAN DER HEYDENIrma LemmensXaveer Van OstadeJoël VandekerckhoveJan Tavernier

A1 Journal Article in NATURE CELL BIOLOGY

Down-modulation of type 1 interferon responses by receptor cross-competition for a shared Jak kinase

E DondiEls PattynG LutfallaXaveer Van OstadeG UzeS PellegriniJan Tavernier

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of mutations of N- and C-terminal charged residues on the activity of LCAT.

Frank PeelmanBerlinda VanlooJean-Luc VerscheldeChristine LabeurH CASTERJ TAVEIRNEA VERHEEN DUVERGERJoël VandekerckhoveJan Tavernier et al.

A1 Journal Article in JOURNAL OF LIPID RESEARCH

Neutralizing monoclonal antibodies can potentiate IL-5 signaling.

Lennart ZabeauJ VAN DER HEYDENDaniël BroekaertA VERHEEJoël VandekerckhoveSJ WUI CHAIKENP HEINRICHI BEHRMANNJan Tavernier

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

2000

A sensitive and versatile bioassay for ligands that signal through receptor clustering

Xaveer Van OstadeLiesbeth SchauvliegeEls PattynAnnick VerheeJoël VandekerckhoveJan Tavernier

A1 Journal Article in JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Evidence for local eosinophil differentiation within allergic nasal mucosa: Inhibition with soluble IL-5 receptor.

L CAMERONP CHRISTODOULOPOULOSF LAVIGNEY NAKAMURAD EIDELMANA MCEUENA WALLSJan TavernierE MINSHALLR MOQBEL et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Headgroup specificity of lecithin cholesterol acyltransferase for monomeric and vesicular phospholipids.

Bart ChristiaensBerlinda VanlooC GOUYETTEInge Van VyncktH CASTERJ TAVEIRNEA VERHEEChristine LabeurFrank PeelmanJoël Vandekerckhove et al.

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Identification and expression analysis of leptin-regulated immediate early response and late target genes

Wim WaelputAnnick VerheeDaniël BroekaertSven EyckermanJoël VandekerckhoveJH BeattieJan Tavernier

A1 Journal Article in BIOCHEMICAL JOURNAL

Identification of the Y985 and Y1077 motifs as SOCS3 recruitment sites in the murine leptin receptor.

Sven EyckermanDaniël BroekaertA VERHEEJoël VandekerckhoveJan Tavernier

A1 Journal Article in FEBS LETTERS

Interleukin 5 regulates the isoform expression of its own receptor alpha-subunit.

Jan TavernierJ VAN DER HEYDENA VERHEEGuy BrusselleXaveer Van OstadeJoël VandekerckhoveJ NORTHSM RANKINAB KAYDS ROBINSON

A1 Journal Article in BLOOD

Interleukin-9 enhances interleukin-5 receptor expression, differentiation, and survival of human eosinophils.

AS GOUNNIB GREGORYE NUTKUF ARISK LATIFAE MINSHALLJ NORTHJan TavernierR LEVITN NICOLAIDES et al.

A1 Journal Article in BLOOD

Relationship between structure and biochemical phenotype of lecithin: cholesterol acyltransferase (LCAT) mutants causing fish-eye disease.

Berlinda VanlooFrank PeelmanKristof DeschuymereJ TAVEIRNEA VERHEEC GOUYETTEChristine LabeurJoël VandekerckhoveJan TavernierMaryvonne Rosseneu

A1 Journal Article in JOURNAL OF LIPID RESEARCH

1999

Analysis of Tyr to Phe and the fa/fa leptin receptor mutations in the PC12 cell line

Sven EyckermanWim WaelputAnnick VerheeDaniël BroekaertJoël VandekerckhoveJan Tavernier

A1 Journal Article in EUROPEAN CYTOKINE NETWORK

Analysis of the Expression Pattern of Human Interleukin-5 Receptor a Isoforms in Vitro

Jan TavernierA VERHEEJoël VandekerckhoveXaveer Van OstadeJ VAN DER HEYDEN

Characterisation of functional residues in the interfacial recognition domain of lecithin cholesterol acyltransferase.

Berlinda VanlooFrank PeelmanChristine LabeurJoël VandekerckhoveJan TavernierMaryvonne Rosseneu

Characterization of functional residues in the interfacial recognition domain of lecithin cholesterol acyltransferase (LCAT).

Frank PeelmanB VANLOOO PEREZ-MENDEZA DECOUTJL VERSCHELDEChristine LabeurN VINAIMONTA VERHEEN DUVERGERR BRASSEUR et al.

A1 Journal Article in PROTEIN ENGINEERING

Contributions of leukemia inhibitory factor receptor and oncostatin M receptor to signal transduction in heterodimeric complexes with glycoprotein 130.

HM HERMANNSS RADTKEC HAANH SCHMITZ-VAN DE LEURJan TavernierPC HEINRICHI BEHRMANN

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Dimerization of the interferon type I receptor IFNaR2-2 is sufficient for induction of interferon effector genes but not for full antiviral activity.

E PATTYNX VAN OSTADEL SCHAUVLIEGEA VERHEEMichaël KalaiJoël VandekerckhoveJan Tavernier

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of natural mutations in lecithin:cholesterol acyltransferase on the enzyme structure and activity

Frank PeelmanJean-Luc VerscheldeBerlinda VanlooChristophe AmpeChristine LabeurJan TavernierJoël VandekerckhoveMaryvonne Rosseneu

A1 Journal Article in JOURNAL OF LIPID RESEARCH

Eosinophil development and bone marrow and tissue eosinophils in atopic asthma.

DS ROBINSONJ NORTHK ZEIBECOGLOUS YINGQ MENGS RANKINQ HAMIDJan TavernierAB KAY

A1 Journal Article in INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Identification of a Leu-Ile internalization motif within the cytoplasmic domain of the leukaemia inhibitory factor receptor.

S THIELI BEHRMANNA TIMMERMANNH DAHMENG MULLER-NEWENF SCHAPERJan TavernierV PITARDPC HEINRICHL GRAEVE

A1 Journal Article in BIOCHEMICAL JOURNAL

LCAT defects and low HDL levels.

Maryvonne RosseneuFrank PeelmanJL VERSCHELDEB VANLOOChristine LabeurJan TavernierJoël Vandekerckhove

A1 Journal Article in ATHEROSCLEROSIS

The cell surface expression level of the human interleukin-5 receptor alpha subunit determines the agonistic/antagonistic balance of the human interleukin-5 E13Q mutein.

Xaveer Van OstadeJ VAN DER HEYDENA VERHEEJoël VandekerckhoveJan Tavernier

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

1998

A proposed architecture for lecithin cholesterol acyl transferase (LCAT): Identification of the catalytic triad and molecular modeling.

Frank PeelmanN VINAIMONTA VERHEEB VANLOOJL VERSCHELDEChristine LabeurS SEGURET-MACEN DUVERGERG HUTCHINSONJoël Vandekerckhove et al.

A1 Journal Article in PROTEIN SCIENCE

Analysis of the expression pattern of the human interleukin 5 a-receptor isoforms in vitro

Jan TavernierA VERHEEJ VANDEKERCKHOVEX VAN OSTADE

Analysis of three human interleukin 5 structures suggests a possible receptor binding mechanism.

JL VERSCHELDEChristophe AmpeYves GuisezC OEFNERJoël VandekerckhoveJan Tavernier

A1 Journal Article in FEBS LETTERS

Contribution of apo A II and LCAT oblique peptides to HDL metabolism

Berlinda VanlooO Perez-MendezG LambertJan TavernierJoël VandekerckhoveR BrasseurMaryvonne Rosseneu

Contribution of apo AII and LCAT oblique peptides to HDL metabolism

Berlinda VanlooO PEREZ-MENDEZG LAMBERTJan TavernierJ VANDEKERCKHOVER BRASSEURMaryvonne Rosseneu

Ectopic interleukin-5 receptor expression promotes proliferation without development in a multipotent hematopoietic cell line.

A PIERCEAD WHETTONPJ OWEN-LYNCHJan TavernierE SPOONCERTM DEXTERCM HEYWORTH

A1 Journal Article in JOURNAL OF CELL SCIENCE

Efficient secretion of biologically active recombinant OB protein (leptin) in Escherichia coli, purification from the periplasm and characterization.

Yves GuisezI FACHELA CAMPFIELDFJ SMITHA FARIDG PLAETINCKJ VAN DER HEYDENJan TavernierWalther FiersP BURN et al.

A1 Journal Article in PROTEIN EXPRESSION AND PURIFICATION

IL 5 receptor regulation in allergie rhinitis and nasal polyposis

Claus BachertJan TavernierC. RudackC. Van Cauwenberghe

A2 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Identification and regulation of expression of leptin induced genes in PC12 cells

Wim WaelputAnnick VerheeDaniël BroekaertSven EyckermanJoël VandekerckhoveJan Tavernier

Interleukin-4, interleukin-5, and granulocyte-macrophage colony-stimulating factor receptor expression in chronic sinusitis and response to topical steroids.

ED WRIGHTS FRENKIELK AL-GHAMDIO GHAFFARP SMALLT TROUTTJan TavernierQ HAMID

A1 Journal Article in OTOLARYNGOLOGY-HEAD AND NECK SURGERY

Colin J SandersonStephane KarlenSigrid CornelisGeert PlaetinckJan TavernierRené Devos

Bookchapter in Cytokines

Internalization of the interleukin 6 signal transducer gp130 does not require activation of the Jak/STAT pathway.

S THIELI BEHRMANNE DITTRICHL MUYSJan TavernierJ WIJDENESPC HEINRICHL GRAEVE

A1 Journal Article in BIOCHEMICAL JOURNAL

1997

A single STAT recruitment module in a chimeric cytokine receptor complex is sufficient for STAT activation.

I BEHRMANNC JANZENC GERHARTZH SCHMITZVANDELEURH HERMANNSB HEESELL GRAEVEF HORNJan TavernierPC HEINRICH

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane-bound and soluble ocIL-5 receptor mRNA in the bronchial mucosa of atopic and nonatopic asthmatics

Z YASRUELM HUMBERTTC KOTSIMBOSY PLOYSONGSANGE MINSHALLS DURHAMR PFISTERG MENZJan TavernierAB KAY et al.

A2 Journal Article in American Journal Respir. Crit. Care MecL, 155, 1413-1418 (1997)

Role of IFN-gamma in the inhibition of the allergic airway inflammation caused by IL-12.

Guy BrusselleJohan KipsRenaat PelemanGuy JoosRR DEVOSJan TavernierRomain Pauwels

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The beta chain of the interleukin-3 receptor functionally associates with the erythropoietin receptor.

PT JUBINSKYOI KRIJANOVSKIDG NATHANJan TavernierCA SIEFF

A1 Journal Article in BLOOD

Upregulation of αGM-CSF receptor in nonatopic asthma but not in atopic asthma

AT KotsimbosM HumbertE MinshallS DurhamR PfisterG MenzJan TavernierAB KayQ Hamid

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

1996

ESM-1 is a novel human endothelial cell-specific molecule expressed in lung and regulated by cytokines.

P LASSALLES MOLETA JANINJ VANDERHEYDENJan TavernierWalther FiersR DEVOSAB TONNEL

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Interleukin-12 inhibits antigen-induced airway hyperresponsiveness in mice.

Johan KipsGuy BrusselleGuy JoosRenaat PelemanJan TavernierRR DEVOSRomain Pauwels

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Interleukin-5 receptor a-subunit gene : regulation in human eosinophil development : identification of a unique Cis-element that acts like an enhancer in regulating activity of the IL-5Ra promoter

Z SunDA YergeauIC WongT TuypensJan TavernierCC PaulMA BaumannPP AuronDG TenenSJ Ackerman

1995

Characterization of critical residues in the cytoplasmic domain of the human interleukin-5 receptor a chain required for growth signal-transduction.

S CORNELISI FACHEJ VANDERHEYDENYves GuisezJan TavernierR DEVOSWalther FiersG PLAETINCK

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Detailed analysis of the IL-5-IL-5Ra interaction - Characterization of crucial residues on the ligand and the receptor.

S CORNELISG PLAETINCKR DEVOSJ VANDERHEYDENJan TavernierCJ SANDERSONYves GuisezWalther Fiers

A1 Journal Article in EMBO JOURNAL

Importance of interleukin-4 and interleukin-12 in allergen-induced airway changes in mice.

Johan KipsGuy BrusselleGuy JoosRenaat PelemanRR DEVOSJan TavernierRomain Pauwels

A1 Journal Article in INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

1994

ATTENUATION OF ALLERGIC AIRWAY INFLAMMATION IN IL-4 DEFICIENT MICE.

Guy BrusselleJohan KipsJan TavernierJG VANDERHEYDENClaude CuvelierRomain PauwelsH BLUETHMANN

A1 Journal Article in CLINICAL AND EXPERIMENTAL ALLERGY

DISSOCIATION OF TNF-ALPHA CYTOTOXIC AND PROINFLAMMATORY ACTIVITIES BY P55 RECEPTOR-SELECTIVE AND P75 RECEPTOR-SELECTIVE TNF-ALPHA MUTANTS.

JAJ BARBARAWB SMITHJR GAMBLEXaveer VANOSTADEPeter VandenabeeleJan TavernierWalther FiersMA VADASAF LOPEZ

A1 Journal Article in EMBO JOURNAL

Human tumor necrosis factor mutants with preferential binding to and activity on either the R55 or R75 receptor.

Xaveer Van OstadePeter VandenabeeleJan TavernierWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

Structure-activity studies of human tumour necrosis factors.

Xaveer Van OstadeJan TavernierWalther Fiers

A1 Journal Article in PROTEIN ENGINEERING

1993

Expression, purification and crystallization of fully active, glycosylated human interleukin-5

Yves GuisezC OEFNERFK WINKLERE SCHLAEGERM ZULAUFJ VAN DER HEYDENG PLAETINCKSigrid CornelisJan TavernierWalther Fiers et al.

A3 Journal Article in FEBS Lett., 331

HUMAN TNF MUTANTS WITH SELECTIVE ACTIVITY ON THE P55 RECEPTOR.

Xaveer Van OstadePeter VandenabeeleBart EveraerdtH LOETSCHERR GENTZM BROCKHAUSW LESSLAUERJan TavernierPeter BrouckaertWalther Fiers

A1 Journal Article in NATURE

THE POTENTIAL ROLE OF TUMOR-NECROSIS-FACTOR-ALPHA IN ASTHMA.

Johan KipsJan TavernierGuy JoosRenaat PelemanRomain Pauwels

A1 Journal Article in CLINICAL AND EXPERIMENTAL ALLERGY

1992

Effect of theophylline on endotoxin and tumor necrosis factor induced airway changes in an in vivo animal model

Johan KipsJan TavernierRenaat PelemanGuy JoosRomain Pauwels

A1 Journal Article in INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Molecular basis of the membrane-anchored and two soluble isoforms of the human interleukin-5 receptor alpha-subunit.

Jan TavernierT TUYPENSG PLAETINCKA VERHEEWalther FiersR DEVOS

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organization and chromosomal localization of the human interleukin 5 receptor cc-chain gene

T TuypensG PlaetinckE BakerG SutherlandGuy BrusselleWalther FiersR DevosJan Tavernier

A2 Journal Article in EUROPEAN CYTOKINE NETWORK

TUMOR-NECROSIS-FACTOR CAUSES BRONCHIAL HYPERRESPONSIVENESS IN RATS.

Johan KipsJan TavernierRomain Pauwels

A1 Journal Article in AMERICAN REVIEW OF RESPIRATORY DISEASE

1991

A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific α chain and a β chain shared with the receptor for GM-CSF

Jan TavernierRené DevosSigrid CornelisTania TuypensJosé Van der HeydenWalther FiersGeert Plaetinck

A1 Journal Article in CELL

Amino acid sequence analysis of a mouse interleukin 5 receptor protein reveals homology with a mouse interleukin 3 receptor protein

René DevosJoël VandekerckhoveAntonius RolinkGeert PlaetinckJosé Van der HeydenWalther FiersJan Tavernier

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Characterization of the murine IL-5 receptor complex with the use of a panel of monoclonal antibodies: relationship to the murine IL-3 receptor

José Van der HeydenRéné DevosGeert PlaetinckIna FacheWalther FiersJan Tavernier

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Localization of the active site of human tumour necrosis factor (hTNF) by mutational analysis

Xaveer Van OstadeJan TavernierThierry PrangéWalther Fiers

A1 Journal Article in EMBO JOURNAL

Molecular basis of a high affinity murine interleukin-5 receptor

René DevosGeert PlaetinckJosé Van der HeydenSigrid CornelisJoël VandekerckhoveWalther FiersJan Tavernier

A1 Journal Article in EMBO JOURNAL

1990

Analysis of the structure-function relationship of tumour necrosis factor: human/mouse chimeric TNF proteins: general properties and epitope analysis

Jan TavernierAnne MarmenoutRita BaudenGuido HauquierXaveer Van OstadeWalther Fiers

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

Characterization of interleukin 5 receptors on eosinophilic sublines from human promyelocytic leukemia (HL-60) cells

Geert PlaetinckJosé Van der HeydenJan TavernierIna FachéTania TuypensSteven FischkoffWalther FiersRené Devos

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Comparative activity of human and murine tumor necrosis factor in toxicity and anti-infectious assays in mice

Francine ParantJan TavernierWalther FiersMonique Parant

A1 Journal Article in MICROBIAL PATHOGENESIS

Expression of the murine interleukin-5 receptor on Xenopus laevis oocytes

René DevosJan TavernierGeert PlaetinckJosé Van der HeydenAntonius RolinkWalther Fiers

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

In vitro and in vivo action of tumor necrosis factor

Walther FiersRudi BeyaertPeter BrouckaertBart EveraerdtGuy HaegemanClaude LibertPhilip SuffysNozomi TakahashiJan TavernierSigrid Van Bladel et al.

1989

Expression of human and murine interleukin-5 in eukaryotic systems

Jan TavernierRené DevosJosé Van der HeydenGuido HauquierRita BaudenIna FachéEric KawashimaJoël VandekerckhoveRoland ContrerasWalther Fiers

A1 Journal Article in DNA-A JOURNAL OF MOLECULAR & CELLULAR BIOLOGY

1988

Slippage of DNA-polymerase-I during synthesis of ds-cDNA

René DevosJan TavernierWalther Fiers

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Structure of tumour necrosis factor by X-ray solution scattering and preliminary studies by single crystal X-ray diffraction

Anita Lewit-BentleyRoger FourmeRichard KahnThierry PrangéPatrice VachetteJan TavernierGuido HauquierWalther Fiers

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

Tumor-selective cytotoxic effects of murine tumor necrosis factor (TNF) and interferon-gamma (IFN-gamma) in organ culture of B16 melanoma cells and heart tissue.

Marcus MareelC DRAGONETTIJan TavernierWalther Fiers

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

Two conserved tryptophan residues of tumor necrosis factor and lymphotoxin are not involved in the biological activity

Xaveer Van OstadeJan TavernierWalther Fiers

A1 Journal Article in FEBS LETTERS

1987

Evidence for tumor necrosis factor cachectin production in cancer

Frances BalkwillFrances BurkeDenis TalbotJan TavernierRichard OsborneStuart NaylorHelga DurbinWalther Fiers

A1 Journal Article in LANCET

Gene cloning and structure: function relationship of cytokines such as TNF and interleukins

Walther FiersRudi BeyaertPeter BrouckaertBart EveraerdtGuy HaegemanPhilip SuffysJan TavernierPeter VandenabeeleBart VanhaesebroeckXaveer Van Ostade et al.

A1 Journal Article in IMMUNOLOGY LETTERS

Induction and regulation of mRNA encoding 26-kDa protein in human cell lines treated with recombinant human tumor necrosis factor

P DefilippiP PoupartJan TavernierWalther FiersJ Content

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recombinant tumor necrosis factor can induce interleukin 2 receptor expression and cytolytic activity in a rat × mouse T cell hybrid

Geert PlaetinckWim DeclercqJan TavernierMarkus NabholzWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Recombinant tumour necrosis factor inhibits malaria parasites in vivo but not in vitro

Janice TaverneJan TavernierWalther FiersJHL Playfair

A1 Journal Article in CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Structure-function relationship of tumor necrosis factor and its mechanism of action

Walther FiersPeter BrouckaertAlfred L GoldbergIsis C KettelhutPhilip SuffysJan TavernierBart VanhaesebroeckFrans Van Roy

A1 Journal Article in CIBA FOUNDATION SYMPOSIA

Toxic effects of recombinant tumor necrosis factor in suckling mice: comparisons with interferon α/β

Ion GresserDavid WoodrowJill MossChantal MauryJan TavernierWalther Fiers

A1 Journal Article in AMERICAN JOURNAL OF PATHOLOGY

Tumor necrosis factor: a potential antitumor agent?

Walther FiersRudi BeyaertPeter BrouckaertBart EveraerdtPhilip SuffysJan TavernierBart VanhaesebroeckFrans Van Roy

A1 Journal Article in JOURNAL OF INTERFERON RESEARCH

1986

Anti-tumor effects of interferon in mice injected with interferon-sensitive and interferon-resistant Friend leukemia cells, V : comparisons with the action of tumor necrosis factor

I GresserF BelardelliJan TavernierWalther FiersF PodoM FedericoG CarpinelliP DuvillardM PradeC Maury et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

Cloning and structure of a mouse interleukin-2 chromosomal gene

Wim DegraveGuus SimonsRené DevosGeert PlaetinckErik RemautJan TavernierWalther Fiers

A1 Journal Article in MOLECULAR BIOLOGY REPORTS

Human tumor xenografts treated with recombinant human tumor necrosis factor alone or in combination with interferons

Frances R BalkwillAudrey LeeGary AldamElaine MoodieJ Alero ThomasJan TavernierWalther Fiers

A1 Journal Article in CANCER RESEARCH

In vivo anti-tumour activity of recombinant human and murine TNF, alone and in combination with murine IFN-γ, on a syngeneic murine melanoma

Peter BrouckaertGeert Leroux-RoelsYves GuisezJan TavernierWalther Fiers

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

Induction of the synthesis of tumor necrosis factor receptors by interferon-γ

Vito RuggieroJan TavernierWalther FiersCorrado Baglioni

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Structural analysis of the sequence coding for an inducible 26-kDa protein in human fibroblasts

Guy HaegemanJean ContentGuido VolckaertRik DerynckJan TavernierWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

1985

Binding of human tumor necrosis factor to high-affinity receptors on HeLa and lymphoblastoid cells sensitive to growth inhibition

Corrado BaglioniSarah McCandlessJan TavernierWalther Fiers

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular cloning and expression of human tumor necrosis factor and comparison with mouse tumor necrosis factor

Anne MarmenoutLucie FransenJan TavernierJosé Van der HeydenRichard TizardEric KawashimaAlan ShawMerrie-Jo JohnsonDominique SemonRita Müller et al.

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

Molecular cloning of mouse tumour necrosis factor cDNA and its eukaryotic expression

Lucie FransenRita MüllerAnne MarmenoutJan TavernierJosé Van der HeydenEric KawashimaAndré CholletRichard TizardHugo Van HeuverswynAdri Van Vliet et al.

A1 Journal Article in NUCLEIC ACIDS RESEARCH

1984

The presence of homologous regions between interferon sequences

Jan TavernierWalther Fiers

A1 Journal Article in CARLSBERG RESEARCH COMMUNICATIONS

1983

Cloning and structure of the human interleukin 2 chromosomal gene

Wim DegraveJan TavernierFred DuerinckGeert PlaetinckRené DevosWalther Fiers

A1 Journal Article in EMBO JOURNAL

Deletion mapping of the inducible promoter of human IFN-β gene

Jan TavernierDirk GheysenFred DuerinckJosé Van der HeydenWalther Fiers

A1 Journal Article in NATURE

Human fibroblast interferon RNA transcripts of different sizes in poly(I).poly(C) induced cells

Jean ContentLucas De WitJan TavernierWalther Fiers

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Molecular cloning of human interleukin 2 cDNA and its expression in E. coli

René DevosGeert PlaetinckHilde CheroutreGuus SimonsWim DegraveJan TavernierErik RemautWalther Fiers

A1 Journal Article in NUCLEIC ACIDS RESEARCH

1982

Cloning and structure of the human immune interferon-γ chromosomal gene

Yoichi TayaRené DevosJan TavernierHilde CheroutreGilbert EnglerWalther Fiers

A1 Journal Article in EMBO JOURNAL

The human fibroblast and human immune interferon genes and their expression in homologous and heterologous cells

Walther FiersErik RemautRené DevosHilde CheroutreRoland ContrerasDirk GheysenWim DegravePatrick StanssensJan TavernierYoichi Taya et al.

A1 Journal Article in PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES

1981

Evidence for a unique human fibroblast interferon (IFN-β1) chromosomal gene, devoid of intervening sequences

Jan TavernierRik DerynckWalther Fiers

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Molecular mechanisms of nucleotide-sequence rearrangements in cDNA clones of human fibroblast interferon mRNA

Guido VolckaertJan TavernierRik DerynckRené DevosWalther Fiers

A1 Journal Article in GENE

Nucleotide sequence of the chromosomal gene for human fibroblast (β1) interferon and of the flanking regions

Wim DegraveRik DerynckJan TavernierGuy HaegemanWalther Fiers

A1 Journal Article in GENE

1980

Isolation and structure of a human fibroblast interferon gene

Rik DerynckJean ContentErik De ClercqGuido VolckaertJan TavernierRené DevosWalther Fiers

A1 Journal Article in NATURE

A.D. Whetton, J. Gordon (ed.) Hemopoietic cell growth factors and their receptors, Blood Cell Biochemistry,New York, Plenum Publishing Corp., 1996, nr.7, pp. 321-361.

Jan TavernierG PLAETINCKY GUISEZJ VAN DER HEYDENJ KIPSR PELEMANR DEVOS

The role of interleukin 5 in the production and function of eosinophils.

Jan TavernierG PLAETINCKY GUISEZJ VAN DER HEYDENJ KIPSR PELEMANR DEVOS

The ß chain of the interleukin-3 receptor functionally associates with the erythropoietin receptor. Blood 90 (5), 1867-1873(1997).

PT JUBINSKYOI KRIJANOVSKIDG NATHANJan TavernierCA SIEFF