Research Explorer

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Researcher

Jan Félix

Publications & Research Data

Awards & Distinctions

29 Results

2025

Antibody-mediated TGF-β1 activation for the treatment of diseases caused by deleterious T cell activity

Fanny LambertJan FélixSéverine WautierEmilie DupreMathieu JamezCamille MichielsMélanie GaignageLore MariënManon LesageBas van der Woning et al.

A1 Journal Article in CELL REPORTS

Lipid-stabilized ICG nanoaggregates for the photodisruption of vitreous opacities

Pouria RamezaniJan FélixMariana Hugo Borges Barreto SilvaIne LentackerRein VerbekeKevin BraeckmansStefaan De SmedtFélix Sauvage

Reanalysis of cryo-EM data reveals ALK-cytokine assemblies with both 2:1 and 2:2 stoichiometries

Jan FélixSteven De MunckJ. Fernando BazanSavvas Savvides

A1 Journal Article in PLOS BIOLOGY

Single-domain antibodies directed against hemagglutinin and neuraminidase protect against influenza B viruses

Arne MatthysJan FélixJoão Portela CataniKenny RooseWim NerinckxBenthe Van BuytenDaria FijalkowskaNico CallewaertSavvas SavvidesXavier Saelens

A1 Journal Article in NATURE COMMUNICATIONS

2024

Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23

Yehudi BlochJan FélixRomain MerceronMathias ProvostRoyan Alipour SymakaniRobin De BackerElisabeth LambertAhmadreza MehdipourSavvas Savvides

A1 Journal Article in NATURE STRUCTURAL & MOLECULAR BIOLOGY

2023

EGOC inhibits TOROID polymerization by structurally activating TORC1

Manoël ProuteauClélia BourgointJan FélixLenny BonadeiYashar SadianCaroline GabusSavvas SavvidesIrina GutscheAmbroise DesfossesRobbie Loewith

A1 Journal Article in NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism of receptor assembly via the pleiotropic adipokine Leptin

Alexandra TsirigotakiAnn DansercoerKoen VerschuerenIva MarkovićChristoph PollmannMaximillian HaferJan FélixCatherine BirckWouter Van PutteDominiek Catteeuw et al.

A1 Journal Article in NATURE STRUCTURAL & MOLECULAR BIOLOGY

2022

Structure of the drug target ClpC1 unfoldase in action provides insights on antibiotic mechanism of action

Katharina WeinhäuplMarcos GrageraM. Teresa Bueno-CarrascoRocío ArranzOlga KrandorTatos AkopianRaquel SoaresEric RubinJan FélixHugo Fraga

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

The AAA+ ATPase RavA and its binding partner ViaA modulate E. coli aminoglycoside sensitivity through interaction with the inner membrane

Jan FélixLadislav BumbaClarissa LiescheAngélique FraudeauFabrice RébeilléJessica Y. El KhouryKarine HuardBenoit GalletChristine MoriscotJean-Philippe Kleman et al.

A1 Journal Article in NATURE COMMUNICATIONS

2021

AAA+ ATPases : structural insertions under the magnifying glass

Matthew JessopJan FélixIrina Gutsche

A1 Journal Article in CURRENT OPINION IN STRUCTURAL BIOLOGY

Proteolysis and multimerization regulate signaling along the two-component regulatory system AdeRS

Zhenlin OuyangFang ZhengLi ZhuJan FélixDi WuKe WuIrina GutscheYi WuPeter M. HwangJunjun She et al.

A1 Journal Article in ISCIENCE

Structural and functional analysis of the Francisella lysine decarboxylase as a key actor in oxidative stress resistance

Jan FélixClaire SiebertJulia Novion DucassouJérôme NigouPierre Simon GarciaAngélique FraudeauKarine HuardCaroline MasCéline Brochier-ArmanetYohann Couté et al.

A1 Journal Article in SCIENTIFIC REPORTS

Structural basis of cytokine-mediated activation of ALK family receptors

Steven De MunckMathias ProvostMichiko KurikawaIkuko OmoriJunko MukohyamaJan FélixYehudi BlochOmar Abdel-WahabJ. Fernando BazanAkihide Yoshimi et al.

A1 Journal Article in NATURE

Supramolecular assembly of the Escherichia coli LdcI upon acid stress

Matthew JessopClarissa LiescheJan FélixAmbroise DesfossesMegghane BaulardVirgile AdamAngélique FraudeauKarine HuardGrégory EffantinJean-Philippe Kleman et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2020

Structural insights into ATP hydrolysis by the MoxR ATPase RavA and the LdcI-RavA cage-like complex

Matthew JessopBenoit ArragainRoger MirasAngélique FraudeauKarine HuardMaria Bacia-VerloopPatrice CattyJan FélixHélène MaletIrina Gutsche

A1 Journal Article in COMMUNICATIONS BIOLOGY

Structure and assembly mechanism of the signaling complex mediated by human CSF-1 (vol 23, pg 1621, 2015)

Jan FélixSteven De MunckKenneth VerstraeteLeander MeurisNico CallewaertJonathan ElegheertSavvas Savvides

Trimeric structure of the mouse Kupffer cell C‐type lectin receptor Clec4f

Zhenlin OuyangJan FélixJinhong ZhouYingmei PeiBohan MaPeter M. HwangM. Joanne LemieuxIrina GutscheFang ZhengYurong Wen

A1 Journal Article in FEBS LETTERS

2019

Atomic structures of an entire contractile injection system in both the extended and contracted states

Ambroise DesfossesHariprasad VenugopalTapan JoshiJan FélixMatthew JessopHyengseop JeongJaekyung HyunJ. Bernard HeymannMark R. H. HurstIrina Gutsche et al.

A1 Journal Article in NATURE MICROBIOLOGY

Mechanism of the allosteric activation of the ClpP protease machinery by substrates and active-site inhibitors

Jan FélixKatharina WeinhäuplChristophe ChipotFrançois DehezAudrey HesselDiego F. GautoCecile MorlotOlga AbianIrina GutscheAdrian Velazquez-Campoy et al.

A1 Journal Article in SCIENCE ADVANCES

Structure, function, and evolution of the pseudomonas aeruginosa lysine decarboxylase LdcA

Eaazhisai KandiahDiego CarrielPierre Simon GarciaJan FélixManuel BanzhafGeorge KritikosMaria Bacia-VerloopCéline Brochier-ArmanetSylvie ElsenIrina Gutsche

A1 Journal Article in STRUCTURE

2017

Mechanisms of immunomodulation by mammalian and viral decoy receptors : insights from structures

Jan FélixSavvas Savvides

A1 Journal Article in NATURE REVIEWS IMMUNOLOGY

2016

Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF

Jan FélixEaazhisai KandiahSteven De MunckYehudi BlochGydo CP van ZundertKris PauwelsAnn DansercoerKatka NovanskaRandy J ReadAlexandre MJJ Bonvin et al.

A1 Journal Article in NATURE COMMUNICATIONS

Structural principles of binding duality in cognate and viral cytokine receptors

Jan FélixSavvas SavvidesEwald Pauwels

2015

Structure and assembly mechanism of the signaling complex mediated by human CSF-1

Jan FélixSteven De MunckKenneth VerstraeteLeander MeurisNico CallewaertJonathan ElegheertSavvas Savvides

A1 Journal Article in STRUCTURE

2014

The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence

Yurong WenEster BehielsJan FélixJonathan ElegheertBjorn VergauwenBart DevreeseSavvas Savvides

A1 Journal Article in NUCLEIC ACIDS RESEARCH

2013

Human IL-34 and CSF-1 establish structurally similar extracellular assemblies with their common hematopoietic receptor

Jan FélixJonathan ElegheertIrina GutscheAlexander ShkumatovYurong WenNathalie BrackeErwin PannecouckeIsabel VandenbergheBart DevreeseDmitri Svergun et al.

A1 Journal Article in STRUCTURE

2012

An REMD and QM/MM study into the sequence effect on asparagine deamidation

Ewald PauwelsSamuel MoorsJan FélixSavvas SavvidesMichel WaroquierVeronique Van SpeybroeckSaron Catak

Effect of the (n +1) residue on peptide deamidation

Saron CatakJan FélixVeronique Van SpeybroeckMichel WaroquierEwald Pauwels

2011

Peptide deamidation : effect of neighboring residues

Saron CatakJan FélixSavvas SavvidesVeronique Van SpeybroeckMichel WaroquierEwald Pauwels