Research Explorer

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Researcher

Jan De Bleecker

Awards & Distinctions

399 Results

2024

Comparison of clinical features between patients with anti-synthetase syndrome and dermatomyositis : results from the MYONET registry

Ryan Malcolm HumJames B LillekerJanine A LambAlexander G S OldroydGuochun WangLucy R WedderburnLouise P DiederichsenJens SchmidtMaria Giovanna DanieliPaula Oakley et al.

A1 Journal Article in RHEUMATOLOGY

Long-term safety, tolerability, and efficacy of efgartigimod (ADAPT+) : interim results from a phase 3 open-label extension study in participants with generalized myasthenia gravis

James F. HowardVera BrilTuan VuChafic KaramStojan PericJan De BleeckerHiroyuki MuraiAndreas MeiselSaid R. BeydounMamatha Pasnoor et al.

A1 Journal Article in FRONTIERS IN NEUROLOGY

Potential new autoimmune target in inclusion body myositis

A NotarnicolaC HellstromB HoruluogluC PregerF BonomiBoel De PaepeJan De BleeckerA Van der KooiM de VisserS Sacconi et al.

2023

Advance care planning in amyotrophic lateral sclerosis and other chronic life-limiting conditions : patients' and family carers' perspectives

Isabel VandenbogaerdeAline De VleminckLuc DeliensLieve Van den BlockJan De Bleecker

Anoctamin-5 related muscle disease : clinical and genetic findings in a large European cohort

Alexander de BruynFederica MontagneseSonja Holm-YildizNanna Scharff PoulsenTanya StojkovicAnthony BehinJohanna PalmioManu JokelaJan De BleeckerMarianne de Visser et al.

A1 Journal Article in BRAIN

C-terminal frameshift variant of TDP-43 with pronounced aggregation-propensity causes rimmed vacuole myopathy but not ALS/FTD

Pedro Ervilha PereiraNika SchuermansAntoon MeylemansPontus LeBlancLauren VersluysKE CopleyJD RubienC AltheimerMyra PeetermansElke Debackere et al.

A1 Journal Article in ACTA NEUROPATHOLOGICA

Exome sequencing and multigene panel testing in 1,411 patients with adult-onset neurologic disorders

Nika SchuermansHannah VerdinJody GhijselsMadeleine HellemansElke DebackereElke BogaertSofie SymoensLeslie NaesensElien LecomteDavid Crosiers et al.

A1 Journal Article in NEUROLOGY-GENETICS

Identification of novel associations and localization of signals in idiopathic inflammatory myopathies using genome‐wide imputation

Simon RothwellChristopher I. AmosFrederick W. MillerLisa G. RiderIngrid E. LundbergPeter K. GregersenJiri VencovskyNeil McHughVidya LimayeAlbert Selva‐O'Callaghan et al.

A1 Journal Article in ARTHRITIS & RHEUMATOLOGY

Low gene copy numbers of complement C4 and complement C4A deficiency are strong and highly significant genetic risk factors for idiopathic inflammatory myopathy and its major subgroups

Daniel ZhouEmily KingSimon RothwellOlga KrystufkovaAntonella NotarnicolaRabheh AzizEmeli LundstromBlanka StiburkovaLauren PachmanGulnara Mamyrova et al.

Osmolytes and their therapeutic applicability in the mdx mouse

Caroline MerckxJan De BleeckerBoel De Paepe

Retrospective study shows that serum levels of chemokine CXCL10 and cytokine GDF15 support a diagnosis of sporadic inclusion body myositis and immune-mediated necrotizing myopathy

Boel De PaepeKen BrackeJan De Bleecker

A1 Journal Article in BRAIN SCIENCES

Wat zijn de ervaringen van personen met amyotrofische laterale sclerose (ALS) en hun mantelzorgers met vroegtijdige zorgplanning?

Isabel VandenbogaerdeLieve Van den BlockLuc DeliensEmma CarduffAgnes van der HeideJan De BleeckerAline De Vleminck

A4 Journal Article in NEURONE (NEDERLANDSE ED.)

2022

A structural variant of the C-terminal prion-like domain of TDP-43 causes vacuolar muscle degeneration

Pedro Ervilha PereiraNika SchuermansAntoon MeylemansPontus LeBlancL VersluysElke DebackereOlivier VanakkerSara JanssensJonathan BaetsK Verhoeven et al.

Advance care planning in amyotrophic lateral sclerosis (ALS) : study protocol for a qualitative longitudinal study with persons with ALS and their family carers

Isabel VandenbogaerdeRose MirandaJan De BleeckerEmma CarduffAgnes van der HeideLieve Van den BlockLuc DeliensAline De Vleminck

A1 Journal Article in BMJ OPEN

An exploratory study of circulating cytokines and chemokines in patients with muscle disorders proposes CD40L and CCL5 represent general disease markers while CXCL10 differentiates between patients with an autoimmune myositis

Boel De PaepeKen BrackeJan De Bleecker

A2 Journal Article in CYTOKINE. X

Belgian retrospective survey of hereditary transthyretin-mediated (hATTR) amyloidosis patients treated with patisiran in real-world practice

S TilleuxJan De BleeckerK ClaeysS DestancheV Van ParysJonathan BaetsG Remiche

Clinical features of extra-muscular disease in dermatomyositis and anti-synthetase syndrome patients with skin involvement classified by presence of disease-specific autoantibodies : results from the EuroMyositis registry

Ryan M HumJames B LillekerJanine A LambWilliam E OllierGuochung WangLucy R WedderburnLouise P DiederichsenJens SchmidtPaula OakleyOlivier Benveniste et al.

Description of osmolyte pathways in maturing MDX mice reveals altered taurine and sodium/myo-inositol co-transporter levels

Caroline MerckxGwenny CosemansJana ZschuentzschJens SchmidtBoel De PaepeJan De Bleecker

Description of osmolyte pathways in maturing mdx mice reveals altered levels of taurine and sodium/myo-inositol co-transporters

Caroline MerckxGwenny CosemansJana ZschüntzschRobrecht RaedtJens SchmidtBoel De PaepeJan De Bleecker

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Een ischemische beroerte als presentatie van een occulte maligniteit : typisch beeld op een MRI van de hersenen

H. EngelsM. LemmerlingJan De Bleecker

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Efficacy of efgartigimod in generalized myasthenia gravis : myasthenia gravis composite score analysis from ADAPT

Jan De BleeckerA MeiselJ Howard JrT VuV BrilP UlrichtsA GugliettaChristophe T'JoenH MuraiK Utsugisawa et al.

Expanded phenotyping by microscopic imaging

Frank RoelsPATRICK VERLOOBoel De PaepeJan De BleeckerRudy Van Coster

Expanding the TDP-43 proteinopathy pathway from neurons to muscle : physiological and pathophysiological functions

Lauren VersluysPedro Ervilha PereiraNika SchuermansBoel De PaepeJan De BleeckerElke BogaertBart Dermaut

A1 Journal Article in FRONTIERS IN NEUROSCIENCE

Exploring the therapeutic potential of ectoine in Duchenne Muscular Dystrophy : comparison with taurine, a supplement with known beneficial effects in the mdx mouse

Caroline MerckxJana ZschüntzschStefanie MeyerRobrecht RaedtHanne VerschuereJens SchmidtBoel De PaepeJan De Bleecker

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

HATTR-polyneuropathie : diagnose en behandeling

Jan De BleeckerElke De Vos

A2 Journal Article in SPECIALIST. ACTUALITEIT VOOR DE ARTS-SPECIALIST

Hematological effects of intravenous immunoglobulin therapy in patients with neuromuscular diseases : a retrospective analysis

Jan De Bleecker

Het ‘three territory sign’ als een merker van occulte maligniteit bij een beroerte

Heleen EngelsMarc LemmerlingJan De Bleecker

A2 Journal Article in TIJDSCHRIFT VOOR NEUROLOGIE & NEUROCHIRURGIE

Inducible heat shock protein 70 levels in patients and the mdx mouse affirm regulation during skeletal muscle regeneration in muscular dystrophy

Gwenny CosemansCaroline MerckxJan De BleeckerBoel De Paepe

A2 Journal Article in FRONTIERS IN BIOSCIENCE (SCHOLAR ED.)

Neuromusculaire aandoeningen

NBM VoetJan De Bleecker

Bookchapter in Revalidatie voor volwassenen

Osmotic stress-associated sodium/myo-inositol co-transporter is upregulated in skeletal muscle of the mdx mouse

Caroline MerckxGwenny CosemansJana ZschuentzschJens SchmidtJan De BleeckerBoel De Paepe

Risk of malignant hyperthermia in patients carrying a variant in the ryanodine receptor 1 gene

Sarah HerdewynL JanssensJ De PuydtSofie SymoensJan De Bleecker

Shortcutting the diagnostic odyssey : the multidisciplinary program for undiagnosed rare diseases in adults (UD-PrOZA)

Nika SchuermansDimitri HemelsoetWim TerrynSanne SteyaertRudy Van CosterPaul CouckeWouter SteyaertBert CallewaertElke BogaertPatrick Verloo et al.

A1 Journal Article in ORPHANET JOURNAL OF RARE DISEASES

Two-years prospective natural history study in 24 adult LGMDR12 patients : clinical and radiological outcome measures

B De WelL HuysmansR PeetersV GoosensS GhyselsK ByloosG PutzeysA D'HondtJan De BleeckerP Dupont et al.

Unraveling the molecular basis of the dystrophic process in limb-girdle muscular dystrophy LGMD-R12 by differential gene expression profiles in diseased and healthy muscles

Christophe E. DepuydtVeerle GoosensRekin’s JankyAnn D’HondtJan De BleeckerNathalie NoppeStefaan DerveauxDietmar R. ThalKristl G. Claeys

A1 Journal Article in CELLS

2021

Case report : olanzapine post-injection delirium/sedation syndrome mimicking brainstem-thrombosis

Arthur PollentierMarijke VergaelenJan De Bleecker

A1 Journal Article in ACTA NEUROLOGICA BELGICA

Contribution of homozygous and compound heterozygous missense mutations in VWA2 to Alzheimer's disease

J HoogmartensE HensS EngelborghsR VandenberghePP De DeynR CacaceC Van BroeckhovenBELNEU ConsortiumP. CrasJ. Goeman et al.

A1 Journal Article in NEUROBIOLOGY OF AGING

Diagnostic muscle biopsies in the era of genetics : the added value of myopathology in a selection of limb-girdle muscular dystrophy patients

Boel De PaepeElise VelgheLinnea SalminenBalint TothPieter OlivierJan De Bleecker

A1 Journal Article in ACTA NEUROLOGICA BELGICA

Duchenne muscular dystrophy fibrosis potentially explained by abnormal NFAT5 physiology in Duchenne muscular dystrophy fibroblasts

dr. Sandrine HerbeletBoel De PaepeJan De Bleecker

Bookchapter in New Innovations in Chemistry and Biochemistry Vol. 5

Efficacy and safety of Bimagrumab in sporadic inclusion body myositis : long-term extension of RESILIENT

AA AmatoMG HannaPM MachadoUA BadrisingH ChinoyO BenvenisteAK KaranamM WuLB TankóAA Schubert-Tennigkeit et al.

A1 Journal Article in NEUROLOGY

Efficacy and safety of rozanolixizumab in moderate to severe generalized myasthenia gravis : a phase 2 randomized control trial

V BrilM BenatarH AndersenJ VissingM BrockB GreveP KiesslingF WolteringL GriffinP Van den Bergh et al.

A1 Journal Article in NEUROLOGY

Extensive genetic and phenotypic description of MAPT p.R406W in the Flanders-Belgian population

H GossyeS Van MosseveldeJ Van der ZeeY VermeirenN De RoeckA SiebenJan De BleeckerP De DeynP CrasS Engelborghs et al.

Genotype-phenotype correlations in VCP disease : results of an international multicentric study (The VCP study group)

M SchiavaC IkenagaT StojkovicM CaballeroI NishinoB Velez GomezA Alonso JimenezA Kostera-PruszczykF Miralles MorellJan De Bleecker et al.

High-throughput imaging of ATG9A distribution as a diagnostic functional assay for adaptor protein complex 4-associated hereditary spastic paraplegia

Darius Ebrahimi-FakhariJulian E. AlecuBarbara BrechmannMarvin ZieglerKathrin EberhardtHellen JumoAngelica D'AmoreParham HabibzadehMohammad Ali FaghihiJan De Bleecker et al.

A2 Journal Article in BRAIN COMMUNICATIONS

In-depth phenotypic description of TBK1 mutations ; a frequent cause of FTD and ALS in the Flanders-Belgian population

H GossyeS Van MosseveldeJ Van der ZeeY VermeirenN De RoeckJan De BleeckerP CrasP De DeynS EngelborghsTim Van Langenhove et al.

Myositis-specific and myositis-associated autoantibodies predict trajectories of damage over time in idiopathic inflammatory myopathies

F Espinosa-OrtegaM HolmqvistK LodinM DastmalchiMG DanieliJ VenkovskyJ KnitzaS OliveiraLP DiederichsenL Wedderburn et al.

Myotonic dystrophy type 1 as a major risk factor for severe COVID-19?

Sebastiaan DhontRutger CallensDieter StevensFré BautersJan De BleeckerEric DeromEva Van Braeckel

A1 Journal Article in ACTA NEUROLOGICA BELGICA

NFAT5 in myositis and Duchenne muscular dystrophy : localization, expression and interaction with glucocorticoids in in vitro cell models

dr. Sandrine HerbeletJan De BleeckerBoel De Paepe

No association of CpG SNP rs9357140 with onset age in Belgian C9orf72 repeat expansion carriers

Cemile KoçoğluHelena GossyeLubina DillenSara Van MosseveldeJan De BleeckerRik VandenberghePeter P. De DeynKristel SleegersPatrick CrasSebastiaan Engelborghs et al.

A1 Journal Article in NEUROBIOLOGY OF AGING

Post-intervention status in patients with refractory myasthenia gravis treated with eculizumab during REGAIN and its open-label extension

R MantegazzaGI WolfeS MuppidiH WiendlKP FujitaFL O'BrienBooth HDEJF HowardREGAIN Study GroupJan De Bleecker

A1 Journal Article in NEUROLOGY

Safety and efficacy of oral levosimendan in people with amyotrophic lateral sclerosis (the REFALS study) : a randomised, double-blind, placebo-controlled phase 3 trial

Merit CudkowiczAngela GengeNicholas MaragakisSusanne PetriLeonard van den BergValtteri V AhoToni SarapohjaMikko KuoppamäkiChris GarrattAmmar Al-Chalabi et al.

A1 Journal Article in LANCET NEUROLOGY

Safety, efficacy, and tolerability of efgartigimod in patients with generalised myasthenia gravis (ADAPT) : a multicentre, randomised, placebo-controlled, phase 3 trial

James F HowardVera BrilTuan VuChafic KaramStojan PerkTemur MarganiaHiroyuki MuraiMalgorzata BilinskaRoman ShakarishviliMarek Smilowski et al.

A1 Journal Article in LANCET NEUROLOGY

Studies on anti-inflammatory and general glucocorticoid physiology in skeletal muscles affected by Duchenne muscular dystrophy : an approach towards exploration of steroid-sparing agents

dr. Sandrine HerbeletArthur RodenbachBoel De PaepeJan De Bleecker

Bookchapter in Current advances in chemistry and biochemistry, vol. 7

Study of NFAT5 physiology in Duchenne muscular dystrophy fibroblasts : provisionary explanation for the permanent fibrosis formation in Duchenne muscular dystrophy

dr. Sandrine HerbeletBoel De PaepeJan De Bleecker

Bookchapter in Recent Research Advances in Biology Vol. 9

The heterogeneity of immune-mediated necrotizing myopathy illustrated in a cohort of Belgian patients : consequences for diagnosis and disease management

Boel De PaepeJan De Bleecker

Bookchapter in Advances in health and disease

2020

239th ENMC International Workshop : Classification of dermatomyositis, Amsterdam, the Netherlands, 14-16 December 2018

Andrew L. MammenYves AllenbachWerner StenzelOlivier Benvenisteon behalf of the ENMC 239th Workshop Study GrpJan De Bleecker

A1 Journal Article in NEUROMUSCULAR DISORDERS

Abnormal NFAT5 physiology in Duchenne muscular dystrophy fibroblasts as a putative explanation for continuous fibrotic tissue production and the interaction between NFAT5 and glucocorticoid receptor

dr. Sandrine HerbeletBoel De PaepeJan De Bleecker

Abnormal NFAT5 physiology in Duchenne muscular dystrophy fibroblasts as a putative explanation for the permanent fibrosis formation in Duchenne muscular dystrophy

dr. Sandrine HerbeletBoel De PaepeJan De Bleecker

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Anti-inflammatory and general glucocorticoid physiology in skeletal muscles affected by Duchenne muscular dystrophy : exploration of steroid-sparing agents

dr. Sandrine HerbeletArthur RodenbachBoel De PaepeJan De Bleecker

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autoantilichamen bij dermatomyositis

Jan De BleeckerPieter Olivier

A4 Journal Article in NEURONE (NEDERLANDSE ED.)

Consistent improvement with eculizumab across muscle groups in myasthenia gravis

R MantegazzaFL O'BrienM YountzJF HowardREGAIN study groupJan De Bleecker

A1 Journal Article in ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY

Description of a novel mechanism possibly explaining the antiproliferative properties of glucocorticoids in Duchenne muscular dystrophy fibroblasts based on glucocorticoid receptor GR and NFAT5

dr. Sandrine HerbeletBoel De PaepeJan De Bleecker

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Functional characterization of the first missense variant in CEP78, a founder allele associated with cone‐rod dystrophy, hearing loss and reduced male fertility

Giulia AscariFrank PeelmanPietro FarinelliToon RosseelNina LambrechtsKirsten A. WunderlichMatias WagnerKonstantinos NikopoulosPernille MartensIrina Balikova et al.

A1 Journal Article in HUMAN MUTATION

Late-onset Pompe disease (LOPD) in Belgium : clinical characteristics and outcome measures

P VanherpeS FieuwsA D'HondtC BleyenheuftP DemaerelJan De BleeckerP Van den BerghJ BaetsG RemicheK Verhoeven et al.

A1 Journal Article in ORPHANET JOURNAL OF RARE DISEASES

Localization and expression of nuclear factor of activated T-cells 5 in myoblasts exposed to pro-inflammatory cytokines or hyperosmolar stress and in biopsies from myositis patients

dr. Sandrine HerbeletElly De VlieghereAmanda GonçalvesBoel De PaepeKarsten SchmidtEline NysLaurens WeynantsJoachim WeisGert Van PeerJo Vandesompele et al.

Bookchapter in Myokines, adipokines, cytokines in muscle pathophysiology

Long lasting trigeminal neuropathy, limbic encephalitis and abdominal ganglionitis without primary cancer : an atypical case of Hu-Antibody syndrome

Elien De SchamphelaereAnne SiebenSebastien HeyndrickxMartin LammensKarel GeboesJan De Bleecker

A1 Journal Article in CLINICAL NEUROLOGY AND NEUROSURGERY

Multisystem proteinopathy due to a homozygous p.Arg159His VCP mutation : a tale of the unexpected

W De RidderA AzmiCS ClemenL EichingerA HofmannR SchröderK JohnsonA TöpfV StraubP De Jonghe et al.

A1 Journal Article in NEUROLOGY

Myo-inositol transporter SLC5A3 associates with degenerative changes and inflammation in sporadic inclusion body myositis

Boel De PaepeCaroline MerckxJana JarosovaMiryam CannizzaroJan De Bleecker

A1 Journal Article in BIOMOLECULES

New genotype-phenotype correlations in a large European cohort of patients with sarcoglycanopathy

J. Alonso-PérezL. González-QueredaL. BelloM. GuglieriV. StraubP. GallanoC. SempliciniE. PegoraroV. ZangaroA. Nascimento et al.

A1 Journal Article in BRAIN

Pitfalls in the detection of myositis specific antibodies by lineblot in clinically suspected idiopathic inflammatory myopathy

Yves PietteMaxime De SloovereStien VandendriesscheJoke DehoorneJan De BleeckerLiesbet Van PraetAn-Sofie Vander MijnsbruggeSarah De SchepperPeggy JacquesFilip De Keyser et al.

A1 Journal Article in CLINICAL AND EXPERIMENTAL RHEUMATOLOGY

The myokine GDF-15 is a potential biomarker for myositis and associates with the protein aggregates of sporadic inclusion body myositis.

Boel De PaepeFien VerhammeJan De Bleecker

A1 Journal Article in Cytokine

‘Minimal symptom expression’ in patients with acetylcholine receptor antibody-positive refractory generalized myasthenia gravis treated with eculizumab

John VissingSaiju JacobKenji P. FujitaFanny O’BrienJames F. Howard[missing] The REGAIN study groupJan De Bleecker

A1 Journal Article in JOURNAL OF NEUROLOGY

2019

A phase 3 multicenter, prospective, open-label efficacy and safety study of immune globulin (human) 10% caprylate/chromatography purified in patients with myasthenia gravis exacerbations

G KarelisR BalasaJan De BleeckerT StuchevskayaA VillaP Van DammeE LagrangeJM HeckmannM NicolleC Vilciu et al.

A1 Journal Article in EUROPEAN NEUROLOGY

Cladribine in myasthenia gravis : a case urging for prudence

Guy LaureysJan De Bleecker

A1 Journal Article in MUSCLE & NERVE

Current evidence for treatment with nusinersen for spinal muscular atrophy : a systematic review

Antoon MeylemansJan De Bleecker

A1 Journal Article in ACTA NEUROLOGICA BELGICA

Eculizumab improves fatigue in refractory generalized myasthenia gravis

Henning AndersenRenato MantegazzaJing Jing WangFanny O'BrienKaushik PatraJames F, Jr Howardthe REGAIN Study GroupJan De Bleecker

A1 Journal Article in QUALITY OF LIFE RESEARCH

Effect of methylprednisolone on NFAT5 in Duchenne muscular dystrophy fibroblasts

dr. Sandrine HerbeletAmanda GonçalvesJo VandesompeleJan De Bleecker

Efficacy and safety of IVIG in CIDP : combined data of the PRIMA and PATH studies

Ingemar SJ MerkiesIvo N van SchaikJean-Marc LégerVera BrilNan van GelovenHans-Peter HartungRichard A LewisGen SobueJohn-Philip LawoBillie L Durn et al.

A1 Journal Article in JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

Exertional rhabdomyolysis : relevance of clinical and laboratory findings, and clues for investigation

Karel HeytensWillem De RidderJan De BleeckerLuc HeytensJonathan Baets

A1 Journal Article in ANAESTHESIA AND INTENSIVE CARE

Expansion of the role and functional characterization of a missense variant in CEP78 associated with cone-rod dystrophy and hearing loss

Giulia AscariFrank PeelmanPietro FarinelliToon RosseelNina LambrechtsIrina BalikovaLara DeryckeGabriële HoltappelsOlga KryskoThalia Van Laethem et al.

FAHN/SPG35 : a narrow phenotypic spectrum across disease classifications

TW RattayT LindigJ BaetsK SmetsT DeconinckAS SöhnK HörtnagelKN EcksteinS WiethoffJ Reichbauer et al.

A1 Journal Article in BRAIN

Focused HLA analysis in Caucasians with myositis identifies significant associations with autoantibody subgroups

Simon RothwellHector ChinoyJanine A LambFrederick W MillerLisa G RiderLucy R WedderburnNeil J McHughAndrew L MammenZoe E BetteridgeSarah L Tansley et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Healthcare utilization at the end of life in people dying from amyotrophic lateral sclerosis : a retrospective cohort study using linked administrative data

Arno MaetensLuc DeliensJan De BleeckerAugusto CaraceniMark De RidderKim BeernaertJoachim Cohen

A1 Journal Article in JOURNAL OF THE NEUROLOGICAL SCIENCES

Idiopathic inflammatory myopathy : interrater variability in muscle biopsy reading

Pieter OlivierBoel De PaepeEleonora AronicaFlorieke BerfeloRoos ColmanAnthony AmatoDalia DimitriEduard GallardoRomain GherardiHans-Hilmar Goebel et al.

A1 Journal Article in NEUROLOGY

Long-term efficacy and safety of eculizumab in Japanese patients with generalized myasthenia gravis : a subgroup analysis of the REGAIN open-label extension study

H MuraiA UzawaY SuzukiT ImaiH ShiraishiH SuzukiM OkumuraF O'BrienJJ WangKP Fujita et al.

A1 Journal Article in JOURNAL OF THE NEUROLOGICAL SCIENCES

Long-term safety and efficacy of eculizumab in generalized myasthenia gravis

Srikanth MuppidiKimiaki UtsugisawaMichael BenatarHiroyuki MuraiRichard J BarohnIsabel IllaSaiju JacobJohn VissingTed M BurnsJohn T Kissel et al.

A1 Journal Article in MUSCLE & NERVE

Loss of DPP6 in neurodegenerative dementia : a genetic player in the dysfunction of neuronal excitability

Rita CacaceBavo HeemanSara Van MosseveldeArne De RoeckJulie HoogmartensPeter De RijkHelena GossyeKristof De VosWouter De CosterMojca Strazisar et al.

A1 Journal Article in ACTA NEUROPATHOLOGICA

Loss of paraplegin drives spasticity rather than ataxia in a cohort of 241 patients with SPG7

G CoarelliR SchuleBPC van de WarrenburgP De JongheC EwenczykA MartinuzziM SynofzikEG HamerJ BaetsM Anheim et al.

A1 Journal Article in NEUROLOGY

Muscular dystrophy with arrhythmia caused by loss-of-function mutations in BVES

Willem De RidderIsabelle NelsonBob AsselberghBoel De PaepeMaud BeuvinRabah Ben YaouCécile MassonAnne BolandJean-François DeleuzeThierry Maisonobe et al.

A1 Journal Article in NEUROLOGY-GENETICS

Nonsense mutations in alpha-II spectrin in three families with juvenile onset hereditary motor neuropathy

D BeijerT DeconinckJan De BleeckerMT DottiA MalandriniJA UrtizbereaM ZulaicaA López de MunainB AsselberghP De Jonghe et al.

A1 Journal Article in BRAIN

Safety and efficacy of intravenous bimagrumab in inclusion body myositis (RESILIENT) : a randomised, double-blind, placebo-controlled phase 2b trial

MG HannaUA BadrisingO BenvenisteTE LloydM NeedhamH ChinoyM AokiPM MachadoC LiangKA Reardon et al.

A1 Journal Article in LANCET NEUROLOGY

Seronegative patients form a distinctive subgroup of immune-mediated necrotizing myopathy

Johan LimAnke RietveldJan De BleeckerUmesh A BadrisingChristiaan GJ SarisAnneke J van der KooiMarianne de Visser

A1 Journal Article in NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION

The proliferation of Duchenne muscular dystrophy fibroblasts cultured under inflammatory conditions is reduced by methylprednisolone through modulation of NFAT5 localization in the cell

dr. Sandrine HerbeletAmanda GonçalvesJo VandesompeleJan De Bleecker

Two successfully completed pregnancies in adult onset Pompe disease, under continued treatment with alglucosidase alfa

Julie Van HoutteJan De Bleecker

A1 Journal Article in ACTA NEUROLOGICA BELGICA

2018

Aanpak van familiale amyloïdpolyneuropathie

Broes MartensJan De Bleecker

A4 Journal Article in NEURON (NEDERLANDSE ED.)

An intronic VNTR affects splicing of ABCA7 and increases risk of Alzheimer's disease

Arne De RoeckLena DuchateauJasper Van DongenRita CacaceMaria BjerkeTobi Van den BosschePatrick CrasRik VandenberghePeter P De DeynSebastiaan Engelborghs et al.

A1 Journal Article in ACTA NEUROPATHOLOGICA

BVES loss-of-function mutations in limb-girdle muscular dystrophy 2X with cardiac conduction disorders

I NelsonW De RidderB AsselberghBoel De PaepeM BeuvinR Ben YaouA BolandJ DeleuzeT MaisonobeB Eymard et al.

Clinical variability and onset age modifiers in an extended Belgian GRN founder family

Eline WautersSara Van MosseveldeKristel SleegersJulie van der ZeeSebastiaan EngelborghsAnne SiebenRik VandenbergheStephanie PhiltjensMarleen Van den BroeckKarin Peeters et al.

A1 Journal Article in NEUROBIOLOGY OF AGING

Common and rare TBK1 variants in early-onset Alzheimer disease in a European cohort

Jan VerheijenJulie van der ZeeIlse GijselinckTobi Van den BosscheLubina DillenBavo HeemanEstrella Gómez-TortosaAlbert LladóRaquel Sanchez-ValleCaroline Graff et al.

A1 Journal Article in NEUROBIOLOGY OF AGING

Genetic background may contribute to the latitude-dependent prevalence of dermatomyositis and anti-TIF1-γ autoantibodies in adult patients with myositis

Joanna E ParkesSimon RothwellAlexander OldroydHector ChinoyJanine A Lambthe Myositis Genetics Consortium (MYOGEN)Jan De BleeckerBoel De Paepe

A1 Journal Article in ARTHRITIS RESEARCH & THERAPY

Immune checkpoint failures in inflammatory myopathies : an overview

dr. Sandrine HerbeletJan De Bleecker

A1 Journal Article in AUTOIMMUNITY REVIEWS

Induction of osmolyte pathways in skeletal muscle inflammation : novel biomarkers for myositis

Boel De PaepeJana ZschüntzschTea ŠokčevićJoachim WeisJens SchmidtJan De Bleecker

A1 Journal Article in FRONTIERS IN NEUROLOGY

Interpreting genetic variants in titin in patients with muscle disorders

Marco SavareseLorenzo MaggiAnna ViholaPer Harald JonsonGiorgio TascaLucia RuggieroLuca BelloFrancesca MagriTeresa GiuglianoAnnalaura Torella et al.

A1 Journal Article in JAMA NEUROLOGY

Localization and expression of nuclear factor of activated T-cells 5 in myoblasts exposed to pro-inflammatory cytokines or hyperosmolar stress and in biopsies from myositis patients

dr. Sandrine HerbeletElly De VlieghereAmanda GonçalvesBoel De PaepeKarsten SchmidtEline NysLaurens WeynantsJoachim WeisGert Van PeerJo Vandesompele et al.

A1 Journal Article in FRONTIERS IN PHYSIOLOGY

NFAT5 and p38 MAPKs interact in muscle cells responding to osmotic and inflammatory stress and in polymyositis

Boel De Paepedr. Sandrine HerbeletJens SchmidtJan De Bleecker

No supportive evidence for TIA1 gene mutations in a European cohort of ALS-FTD spectrum patients

Yalda Baradaran-HeraviLubina DillenHung Phuoc NguyenSara Van MosseveldeJonathan BaetsPeter De JongheSebastiaan EngelborghsPeter P De DeynMathieu VandenbulckeRik Vandenberghe et al.

A1 Journal Article in NEUROBIOLOGY OF AGING

Single-centre experience on transthyretin familial amyloid polyneuropathy : case series and literature review

Broes MartensMichel De PauwJan De Bleecker

A1 Journal Article in ACTA NEUROLOGICA BELGICA

The EuroMyositis registry : an international collaborative tool to facilitate myositis research

James B LillekerJiri VencovskyGuochun WangLucy R WedderburnLouise Pyndt DiederichsenJens SchmidtPaula OakleyOlivier BenvenisteMaria Giovanna DanieliKatalin Danko et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Truncating SLC5A7 mutations underlie a spectrum of dominant hereditary motor neuropathies

Claire G SalterDanique BeijerHolly HardyKaty ES BarwickMatthew BowerInes MademanPeter De JongheTine DeconinckMark A RussellMeriel M McEntagart et al.

A1 Journal Article in NEUROLOGY-GENETICS

2017

Beyond ALS and FTD : the phenotypic spectrum of TBK1 mutations includes PSP-like and cerebellar phenotypes

Carlo WilkeJonathan BaetsJan De BleeckerTine DeconinckSaskia BiskupStefanie N HayerStephan ZüchnerRebecca SchülePeter De JongheMatthis Synofzik

A1 Journal Article in NEUROBIOLOGY OF AGING

Clinical evidence of disease anticipation in families segregating a C9orf72 repeat expansion

Sara Van MosseveldeJulie van der ZeeIlse GijselinckKristel SleegersJan De BleeckerAnne SiebenRik VandenbergheTim Van LangenhoveJonathan BaetsOlivier Deryck et al.

A1 Journal Article in JAMA NEUROLOGY

Exertional rhabdomyolysis and heat stroke : beware of volatile anesthetic sedation

Karel HeytensJan De BleeckerWalter VerbruggheJonathan BaetsLuc Heytens

A2 Journal Article in WORLD JOURNAL OF CRITICAL CARE MEDICINE

Immune-array analysis in sporadic inclusion body myositis reveals HLA-DRB1 amino acid heterogeneity across the myositis spectrum

Simon RothwellRobert G CooperIngrid E LundbergPeter K GregersenMichael G HannaPedro M MachadoMegan K HerbertGer JM PruijnJames B LillekerMark Roberts et al.

A1 Journal Article in ARTHRITIS & RHEUMATOLOGY

Immunemediated necrotizing autoimmune myopathy : Dutch and Belgian experience

M de VisserJan De BleeckerA Van der KooiF EftimovC SarisN VoermansJ RaaphorstJ LimB Van Engelen

Investigating the role of ALS genes CHCHD10 and TUBA4A in Belgian FTD-ALS spectrum patients

Federica PerroneHung Phuoc NguyenSara Van MosseveldeMatthieu MoisseAnne SiebenPatrick SantensJan De BleeckerMathieu VandenbulckeSebastiaan EngelborghsJonathan Baets et al.

A1 Journal Article in NEUROBIOLOGY OF AGING

Osmolyte accumulator expression is induced in muscle cells in response to inflammation

Boel De PaepeJana ZschuntzschJan De BleeckerJens Schmidt

Osmolyte transporters of Betaine GABA (SLC6Al2) and taurine (SLC5A3) are expressed in muscle-infiltrating mononuclear cells in inflammatory myopathies

Boel De PaepeJoachim WeisJan De Bleecker

TBK1 mutation spectrum in an extended European patient cohort with frontotemporal dementia and amyotrophic lateral sclerosis

Julie van der ZeeIlse GijselinckSara Van MosseveldeFederica PerroneLubina DillenBavo HeemanVeerle BäumerSebastiaan EngelborghsJan De BleeckerJonathan Baets et al.

A1 Journal Article in HUMAN MUTATION

Targeted next-generation sequencing reveals novel TTN mutations causing recessive distal titinopathy

Anni EviläJohanna PalmioAnna ViholaMarco SavareseGiorgio TascaSini PenttiläSara LehtinenPer Harald JonsonJan De BleeckerPeter Rainer et al.

A1 Journal Article in MOLECULAR NEUROBIOLOGY

2016

213th ENMC international workshop: Outcome measures and clinical trial readiness in idiopathic inflammatory myopathies, Heemskerk, The Netherlands, 18-20 September 2015

Olivier BenvenisteLisa G Rideron behalf of the ENMC Myositis Outcomes study groupJan De Bleecker

A1 Journal Article in NEUROMUSCULAR DISORDERS

A comprehensive study of the genetic impact of rare variants in SORL1 in European early-onset Alzheimer's disease

Jan VerheijenTobi Van den BosscheJulie van der ZeeSebastiaan EngelborghsRaquel Sanchez-ValleAlbert LladoCaroline GraffHakan ThonbergPau PastorSara Ortega-Cubero et al.

A1 Journal Article in ACTA NEUROPATHOLOGICA

Activation of osmolyte pathways in inflammatory myopathy and Duchenne muscular dystrophy points to osmoregulation as a contributing pathogenic mechanism

Boel De PaepeJean-Jacques Martindr. Sandrine HerbeletCecilia Jimenez-MallebreraEstibaliz IglesiasCristina JouJoachim WeisJan De Bleecker

A1 Journal Article in LABORATORY INVESTIGATION

Clinical features of TBKI carriers compared with C9orf72, GRN and non-mutation carriers in a Belgian cohort

Sara Van MosseveldeJulie van der ZeeIlse GijselinckSebastiaan EngelborghsAnne SiebenTim Van LangenhoveJan De BleeckerJonathan BaetsMathieu VandenbulckeKoen Van Laere et al.

A1 Journal Article in BRAIN

Complicated spastic paraplegia in patients with AP5Z1 mutations (SPG48)

Jennifer HirstMarianna MadeoKatrien SmetsJames R EdgarLudger ScholsJun LiAnna YarrowTine DeconinckJonathan BaetsElisabeth Van Aken et al.

A2 Journal Article in NEUROLOGY-GENETICS

Comprehensive analysis of TTN coding regions in myopathic patients: challenges and opportunities

M SavareseJan De BleeckerL SantoroG ComiE MercuriM MoraP HackmanB UddV Nigro

Database crossing allows better understanding of neuromuscular disorders epidemiology: the Belgian example

C BleyenheuftP Van DammeN GoemansJan De BleeckerRudy Van CosterP De JongheD BeysenP Van den BerghF ChristiaensA Maertens de Noordhout et al.

Dense genotyping of immune-related loci in idiopathic inflammatory myopathies confirms HLA alleles as the strongest genetic risk factor and suggests different genetic background for major clinical subgroups

Simon RothwellRobert G CooperIngrid E LundbergFrederick W MillerPeter K GregersenJohn BowesJiri VencovskyKatalin DankoVidya LimayeAlbert Selva-O'Callaghan et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

En de 'khat' komt weer...: recidief van een ischemisch cerebraal infarct bij een jongeman

Guy Van den AbeeleK De TroeyerA De PauwMarc LemmerlingJan De Bleecker

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

How robust is ACTIVLIM for the follow-up of activity limitations in patients with neuromuscular diseases?

Charles Sèbiyo BatchoPeter YK Van den BerghPhilip Van DammeAnna J RoyJean-Louis ThonnardMassimo Pentaon behalf of the BNMDR Scientific CommitteeJan De BleeckerRudy Van Coster

A1 Journal Article in NEUROMUSCULAR DISORDERS

Myopathy mimicking an acute coronary syndrome

Thomas De BeenhouwerMattias HofmansJan De BleeckerInger BrandtCarlos Van Mieghem

A1 Journal Article in ACTA CLINICA BELGICA

NFAT5 in Duchenne muscular dystrophy cultured myoblasts after exposure to hyperosmolar salt conditions

dr. Sandrine HerbeletAmanda GonçalvesElly De VlieghereGert Van PeerBoel De PaepeChris GuerinJo VandesompeleOlivier De WeverJan De Bleecker

NFAT5 in inflammatory myopathies and Duchenne muscular dystrophy

dr. Sandrine HerbeletAmanda GonçalvesElly De VlieghereBoel De PaepeChris GuerinOlivier De WeverJan De Bleecker

Osmoregulatory pathways are activated in polymyositis: increased expression of osmolyte accumulators in muscle fibers and immune cells

Boel De PaepeJohan RonnelidJens SchmidtJan De Bleecker

PSP and small vessel disease : more than occasional co-occurence?

Anne SiebenPatrick SantensDimitri HemelsoetSebastiaan EngelborghsPeter De JongheJan De BleeckerJen MaesChristina JadoulPatrick CrasPeter-Paul De Deyn et al.

Phenotypic characteristics of Alzheimer patients carrying an ABCA7 mutation

Tobi Van den BosscheKristel SleegersElise CuyversSebastiaan EngelborghsAnne SiebenArne De RoeckCaroline Van CauwenbergheSteven VermeulenMarleen Van den BroeckAnnelies Laureys et al.

A1 Journal Article in NEUROLOGY

Rare variants in SQSTM1 and VCP genes and risk of sporadic inclusion body myositis

Qiang GangConceicão BettencourtPedro M MachadoStefen BradyJanice L HoltonAlan M PittmanDeborah HughesEstelle HealyMatthew PartonDavid Hilton-Jones et al.

A1 Journal Article in NEUROBIOLOGY OF AGING

The C9orf72 repeat size correlates with onset age of disease, DNA methylation and transcriptional downregulation of the promoter

I GijselinckS Van MosseveldeJ van der ZeeAnne SiebenS EngelborghsJan De BleeckerA IvanoiuO DeryckD EdbauerM Zhang et al.

A1 Journal Article in MOLECULAR PSYCHIATRY

The core protein to myogenesis NFAT5 forms aggresomes in normal and Duchenne muscular dystrophy myotubes exposed to cell stressors

dr. Sandrine HerbeletElly De VlieghereAmanda GonçalvesBoel De PaepeChris GuerinOlivier De WeverJan De Bleecker

The core protein to myogenesis NFAT5 forms aggresomes in normal and Duchenne muscular dystrophy myotubes exposed to cell stressors

dr. Sandrine HerbeletElly De VlieghereGert Van PeerBoel De PaepeEline NysLaurens WeynantsJo VandesompeleOlivier De WeverJens SchmidtJan De Bleecker

The genetic basis of undiagnosed muscular dystrophies and myopathies: results from 504 patients

Marco SavareseGiuseppina Di FruscioAnnalaura TorellaChiara FiorilloFrancesca MagriMarina FaninLucia RuggieroGiulia RicciGuja AstreaLuigia Passamano et al.

A1 Journal Article in NEUROLOGY

2015

205th ENMC international workshop: pathology diagnosis of idiopathic inflammatory myopathies part II, 28-30 March 2014, Naarden, The Netherlands

Jan De BleeckerBoel De Paepefor the ENMC Myositis Muscle Biopsy Study groupAnthony AmatoEleonora AronicaOlivier BenvenisteOnno de BoerMarianne de VisserMazen DimachkieRomain Gherardi et al.

A1 Journal Article in NEUROMUSCULAR DISORDERS

A 22-single nucleotide polymorphism Alzheimer's disease risk score correlates with family history, onset age, and cerebrospinal fluid Aβ42

Kristel SleegersKarolien BettensArne De RoeckCaroline Van CauwenbergheElise CuyversJan VerheijenHanne StruyfsJasper Van DongenSteven VermeulenSebastiaan Engelborghs et al.

A1 Journal Article in ALZHEIMERS & DEMENTIA

Activation of the nuclear factor of activated T-cells 5 pathway is characteristic of the perifascicular muscle fiber atrophy observed in dermatomyositis

Boel De PaepeCecilia Jimenez-MallebreraE IglesiasC JouJean-Jacques MartinJoachim Weisdr. Sandrine HerbeletJan De Bleecker

Addition of NaCl upregulates NFAT5 expression in Duchenne muscular dystrophy cultured myotubes

Laurens WeynantsEline Nysdr. Sandrine HerbeletBoel De PaepeElly De VlieghereLiselot MusLynn FeysOlivier De WeverJan De Bleecker

Cytomegalovirus-induced myeloradiculopathy in an immunocompetent patient

Laurens WeynantsEline NysJan De Bleecker

A1 Journal Article in ACTA NEUROLOGICA BELGICA

Early stages of building a rare disease registry, methods and 2010 data from the Belgian Neuromuscular Disease Registry (BNMDR)

Anna J RoyPeter Van den BerghPhilip Van DammeKris DoggenViviane Van Casterenthe BNMDR Scientific CommitteeJan De BleeckerRudy Van Coster

A1 Journal Article in ACTA NEUROLOGICA BELGICA

Forearm deoxyhemoglobin and deoxymyoglobin (deoxy[Hb + Mb]) measured by near-infrared spectroscopy (NIRS) using a handgrip test in mitochondrial myopathy

Bert CelieJan BooneJoél SmetArnaud VanlanderJan De BleeckerRudy Van CosterJan Bourgois

A1 Journal Article in APPLIED SPECTROSCOPY

Giant arachnoid granulation of the posterior temporal bone wall mimicking a jugular foramen mass

ANNE-SOPHIE MONTEJan De BleeckerKurt BuccauwThierry BoulangerLaurens De Cocker

Editorial material

Het postpoliosyndroom

Ann MertensJan De Bleecker

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Het postpoliosyndroom [antwoord]

Ann MertensJan De Bleecker

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Huge variability in a huge gene: TTN variants identified in a large NGS-resequencing project

M SavareseA EvilaG Di FruscioA ViholaA TorellaG TascaF MagriSandra JanssensL RuggieroKathleen Claes et al.

Hyperacute presentation of encephalomyelitis 10 days after onset of mycoplasma pneumoniae infection

Vincent KeeremanAlfred MeursJan De Bleecker

Inflammatory- and NaCl-induced expression of NFAT5 in muscle cells point to common stress response mechanisms

dr. Sandrine HerbeletKarsten SchmidtJana ZschüntzschEline NysLaurens WeynantsBoel De PaepeOlivier De WeverJan De BleeckerJens Schmidt

Investigating the role of filamin C in Belgian patients with frontotemporal dementia linked to GRN deficiency in FTLD-TDP brains

Jonathan JanssensStephanie PhiltjensGernot KleinbergerSara Van MosseveldeJulie van der ZeeRita CacaceSebastiaan EngelborghsAnne SiebenJulia Banzhaf-StrathmannLubina Dillen et al.

A1 Journal Article in ACTA NEUROPATHOLOGICA COMMUNICATIONS

Loss of TBK1 is a frequent cause of frontotemporal dementia in a Belgian cohort

Ilse GijselinckSara Van MosseveldeJulie van der ZeeAnne SiebenStephanie PhiltjensBavo HeemanSebastiaan EngelborghsMathieu VandenbulckeGreet De BaetsVeerle Baumer et al.

A1 Journal Article in NEUROLOGY

NFAT5 forms aggregates in normal and Duchenne muscular dystrophy cultured myotubes after exposure to cell stressors

dr. Sandrine HerbeletIlse BeckZuzanna DrebertOlivier De WeverJan De Bleecker

Necrotizing myopathy as a paraneoplastic syndrome associated with renal cell carcinoma

Eline NaertJan De BleeckerNicolaas LumenSylvie Rottey

A1 Journal Article in ACTA CLINICA BELGICA

Neurological involvement in Erdheim–Chester disease

Eline NysLaurens WeynantsBénédicte VanneuvilleMarc LemmerlingJan De Bleecker

A1 Journal Article in ACTA NEUROLOGICA BELGICA

Next generation sequencing on patients with LGMD and nonspecific myopathies: findings associated with ANO5 mutations

Marco SavareseGiuseppina Di FruscioGiorgio TascaLucia RuggieroSandra JanssensJan De BleeckerMarc DelpechOlimpia MusumeciAntonio ToscanoCorrado Angelini et al.

A1 Journal Article in NEUROMUSCULAR DISORDERS

Pro-inflammatory cell stress in muscle cells is directed by NFAT5

dr. Sandrine HerbeletJens SchmidtOlivier De WeverEline NysLaurens WeynantsDorien ClarisseGlenn VergauwenBoel De PaepeJan De Bleecker

SQSTM1 and VCP mutations in a series of 205 inclusion body myositis cases

Q GangC BettencourtS BradyJL HoltonAM PittmanD HughesE HealyM PartonD Hilton-JonesPB Shieh et al.

Systematic protein-protein interaction and pathway analyses in the idiopathic inflammatory myopathies

Joanna ParkesSimon RothwellPhilip DayNeil J McHughZoë BetteridgeRobert CooperWilliam E OllierHector ChinoyJanine Lambthe MYOGEN group et al.

The effects of an intronic polymorphism in TOMM40 and APOE genotypes in sporadic inclusion body myositis

Qiang GangConceicao BettencourtPedro M MachadoZoe FoxStefen BradyEstelle HealyMatt PartonJanice L HoltonDavid Hilton-JonesPerry B Shieh et al.

A1 Journal Article in NEUROBIOLOGY OF AGING

2014

Development of a disease severity scale for Becker muscular dystrophy

JC van den BergenBHA WokkeP van DammeAJ van der KooiJan De BleeckerPeter De JongheJJ verschuuren

Did lightning strike twice?

Sara SenecaE FosselleJan De BleeckerKim VancampenhoutWilly LissensK StouffsA JonckheereRudy Van CosterJoél SmetBoel De Paepe et al.

Forearm muscle oxygenation responses during and following arterial occlusion in patients with mitochondrial myopathy

Jan BooneBert CelieJasmien DumortierThomas J BarstowJan De BleeckerJoél SmetArnaud VanlanderRudy Van CosterJan Bourgois

A1 Journal Article in RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

International immunochip study in the idiopathic inflammatory myopathies identifies novel susceptability loci and confirms HLA as strongest genetic risk factor

Simon RothwellRobert G CooperIngrid E LundbergFrederick W MillerPeter K GregersenJiri VencovskyKatalin DankoLucy R WedderburnVidya LimayeAlbert Selva O'Callaghan et al.

Investigating the role of rare heterozygous TREM2 variants in Alzheimer's disease and frontotemporal dementia

Elise CuyversKarolien BettensStéphanie PhiltjensTim Van LangenhoveIlse GijselinckJulie van der ZeeSebastiaan EngelborghsMathieu VandenbulckeJasper Van DongenNathalie Geerts et al.

A1 Journal Article in NEUROBIOLOGY OF AGING

NFAT5 in idiopathic inflammatory myopathies and Duchenne muscular dystrophy

dr. Sandrine HerbeletJens SchmidtBoel De PaepeLaurens WeynantsEline NysKim CreusJan De Bleecker

2013

193rd ENMC International workshop: Pathology diagnosis of idiopathic inflammatory myopathies, 30 November-2 December 2012, Naarden, The Netherlands

Jan De BleeckerIngrid E LundbergMarianne de Visserthe ENMC Myositis Muscle Biopsy Study GroupBoel De Paepe

A1 Journal Article in NEUROMUSCULAR DISORDERS

Cytokines and chemokines as regulators of skeletal muscle inflammation: presenting the case of Duchenne muscular dystrophy

Boel De PaepeJan De Bleecker

A1 Journal Article in MEDIATORS OF INFLAMMATION

Dexpramipexole versus placebo for patients with amyotrophic lateral sclerosis (EMPOWER): a randomised, double-blind, phase 3 trial

Merit E CudkowiczLeonard H van den BergJeremy M ShefnerHiroshi MitsumotoJesus S MoraAlbert LudolphOrla HardimanMichael E BozikEvan W IngersollDonald Archibald et al.

A1 Journal Article in LANCET NEUROLOGY

Diagnostic hallmarks and pitfalls in late-onset progressive transthyretin-related amyloid-neuropathy

Maike F DohrnChristoph RöckenJan De BleeckerJean-Jacques MartinMatthias VorgerdPeter Y Van den BerghAndreas FerbertKatrin HinderhoferJ Michael SchröderJoachim Weis et al.

A1 Journal Article in JOURNAL OF NEUROLOGY

Distinct clinical characteristics of C9orf72 expansion carriers compared with GRN, MAPT, and nonmutation carriers in a Flanders-Belgian FTLD cohort

Tim Van LangenhoveJulie van der ZeeIlse GijselinckSebastiaan EngelborghsRik VandenbergheMathieu VandenbulckeJan De BleeckerAnne SiebenJan VersijptAdrian Ivanoiu et al.

A1 Journal Article in JAMA NEUROLOGY

Edoxaban versus warfarin in patients with atrial fibrillation

Robert P GiuglianoChristian T RuffEugene BraunwaldSabina A MurphyStephen D WiviottJonathan L HalperinAlbert L WaldoMichael D EzekowitzJeffrey I WeitzJindřich Špinar et al.

A1 Journal Article in NEW ENGLAND JOURNAL OF MEDICINE

Efficacy and safety of Privigen® in patients with chronic inflammatory demyelinating polyneuropathy: results of a prospective, single-arm, open-label Phase III study (the PRIMA study)

Jean-Marc LégerJan De BleeckerClaudia SommerWim RobberechtMika SaarelaJerzy KamienowskiZbigniew StelmasiakOrell MielkeBjörn TackenbergAmgad Shebl et al.

A1 Journal Article in JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

Explorative genetic study of UBQLN2 and PFN1 in an extended Flanders-Belgian cohort of frontotemporal lobar degeneration patients

Lubina DillenTim Van LangenhoveSebastiaan EngelborghsMathieu VandenbulckeStayko SarafovIvailo TournevCeline MerlinPatrick CrasRik VandenberghePeter P De Deyn et al.

A1 Journal Article in NEUROBIOLOGY OF AGING

Les cytokines TNF dans les myopathies inflammatoires: une cible thérapeutique potentielle

Boel De PaepeJan De Bleecker

A4 Journal Article in NEURONE (EDITION FRANCAISE)

Morphological spectrum and clinical features of myopathies with tubular aggregates

Fabian FunkChantal Ceuterick-de GrooteJean-Jacques MartinAxel MeinhardtAna TaratutoJan De BleeckerRudy Van CosterBoel De PaepeUlrike ScharaMatthias Vorgerd et al.

A1 Journal Article in HISTOLOGY AND HISTOPATHOLOGY

TNF-cytokines in inflammatoire myopathieën: potentiële targets voor behandeling

Boel De PaepeJan De Bleecker

A4 Journal Article in NEURON (NEDERLANDSE ED.)

The nonnecrotic invaded muscle fibers of polymyositis and sporadic inclusion body myositis: on the interplay of chemokines and stress proteins

Boel De PaepeJan De Bleecker

A1 Journal Article in NEUROSCIENCE LETTERS

Time to response for immunoglobulins in the treatment of CIDP

J-M LegerJan De BleeckerM SaarelaZ StelmasiakA BauhoferO ZenkerO MielkeISJ MerkiesB TackenbergCL Sommer

2012

A C9orf72 promoter repeat expansion in a Flanders-Belgian cohort with disorders of the frontotemporal lobar degeneration-amyotrophic lateral sclerosis spectrum : a gene identification study

Ilse GijselinckTim Van LangenhoveJulie van der ZeeKristel SleegersStephanie PhiltjensGernot KleinbergerJonathan JanssensKarolien BettensCaroline Van CauwenbergheSandra Pereson et al.

A1 Journal Article in LANCET NEUROLOGY

Distinct clinical characteristics of C9orf72 expansion carriers compared to GRN, MAPT and non-mutation carries in a Flanders-Belgian FTLD cohort

Tim Van LangenhoveJulie van der ZeeIlse GijselinckSebastiaan EngelborghsRik VandenbergheMathieu VandenbulckeJan De BleeckerAnne SiebenAdrian IvanoiuOliver Deryck et al.

Efficacy of privigen in patients with chronic inflammatory demyelinating polyneuropathy: results from the PRIMA study

J LegerJan De BleeckerWim RobbrechtM SaarelaJ KamienowskiZ StelmasiakA BauhoferO MielkeO ZenkerISJ Merkies et al.

Expression of chemokines and their receptors in muscle tissues from Duchenne muscular dystrophy patients

Boel De PaepeKim CreusJ-J MartinJan De Bleecker

Forearm deoxygenation measured by Nirs during a new handgrip exercise protocol in patients with mitochondrial myopathy

Bert CelieJan BooneJoél SmetJan De BleeckerRudy Van CosterJan Bourgois

Heat shock protein families 70 and 90 in Duchenne muscular dystrophy and inflammatory myopathy: balancing muscle protection and destruction

Boel De PaepeKim CreusJoachim WeisJan De Bleecker

A1 Journal Article in NEUROMUSCULAR DISORDERS

Het guillain-barrésyndroom tijdens de zwangerschap: een casus

Nele PhilipsGuy VanderstraetenANNICK VIAENEJan De BleeckerKristien RoelensAnnick Debuysscher

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Lymphotoxin beta : an important cytokine in inflammatory myopathy

Kim CreusBoel De PaepeJ WeisJan De Bleecker

Resolution of abnormal fractional anisotropy of substantia nigra in organophosphate intoxication. C. Swinnen et al., Acta Neurologica Belgica (2011) 111:378

Jan De Bleecker

Editorial material

TNF-cytokines in inflammatoire myopathieën : potentiële targets voor behandeling

Boel De PaepeJan De Bleecker

A2 Journal Article in ORTHO-RHEUMATO

The multifaceted character of the cytokine lymphotoxinβ in inflammatory myopathies

Jan De BleeckerKim CreusJoachim WeisBoel De Paepe

The tumor necrosis factor superfamily of cytokines in the inflammatory myopathies : potential targets for therapy

Boel De PaepeKim CreusJan De Bleecker

A1 Journal Article in CLINICAL & DEVELOPMENTAL IMMUNOLOGY

Upregulation of chemokines and their receptors in Duchenne muscular dystrophy: potential for attenuation of myofiber necrosis

Boel De PaepeKim CreusJean-Jacques MartinJan De Bleecker

A1 Journal Article in MUSCLE & NERVE

2011

Localization of chemokines and their receptors in muscle tissues from Duchenne muscular dystrophy patients

Jan De BleeckerKim CreusJean Jacques MartinBoel De Paepe

MRI findings in giant pontine capillary telangiectasis associated with a developmental venous anomaly

H N OzcanS AvcuJan De BleeckerM Lemmerling

A1 Journal Article in JBR-BTR

Phenotypic spectrum in myopathies with tubular aggregates

F FunkC Ceuterick-de GrooteJJ MartinA MeinhardtJan De BleeckerP de JongheAL TaratutoM SaccolitiJ. M. SchroderJB Schulz et al.

2010

Expression of heat shock proteins in skeletal muscle from idiopathic inflammatory myopathy and Duchenne muscular dystrophy patients

Jan De BleeckerKim CreusJean-Jacques MartinJoachim WeisBoel De Paepe

Progressive myoclonic epilepsy as an adult-onset manifestation of Leigh syndrome due to m.14487T > C

Bart DermautS SenecaL DomK SmetsL CeulemansJoél SmetBoel De PaepeS TousseynS WeckhuysenM Gewillig et al.

A1 Journal Article in JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Ptosis as an associated finding in maternally inherited diabetes and deafness

KIRSTEN ROBBERECHTCHRISTIAN DECOCKAnnemie StevensSara SenecaJan De BleeckerBart Leroy

A1 Journal Article in OPHTHALMIC GENETICS

2009

A Dual Role for HSP90 and HSP70 in the Inflammatory Myopathies From Muscle Fiber Protection to Active Invasion by Macrophages

Boel De PaepeKim CreusJJ MartinJ WeisJan De Bleecker

A1 Journal Article in ANNALS OF THE NEW YORK ACADEMY OF SCIENCES

Ataxia with oculomotor apraxia type 2: clinical, biological and genotype/phenotype correlation study of a cohort of 90 patients

M AnheimB MongaM FleuryP CharlesC BarbotM SalihJP DelaunoyM FritschL ArningM Synofzik et al.

A1 Journal Article in BRAIN

Distribution of the NF-kappa B Complex in the Inflammatory Exudates Characterizing the Idiopathic Inflammatory Myopathies

Kim CreusBoel De PaepeBART WERBROUCKVEERLE VERVAETJ WeisJan De Bleecker

A1 Journal Article in ANNALS OF THE NEW YORK ACADEMY OF SCIENCES

Effect of atorvastatin in elderly patients with recent stroke or transient ischemic attack

S ChaturvediJ ZivinA BreaznaP AmarencoA CallahanL GoldsteinM HennericiH SillesenA RudolphM Welch et al.

A1 Journal Article in NEUROLOGY

Expression of HSP90 alpha and HSP90 beta in the idiopathic inflammatory myopathies and Duchenne muscular dystrophy

Jan De BleeckerBoel De PaepeKim CreusJJ MartinJ Weis

Histochemical methods for the diagnosis of mitochondrial diseases

Boel De PaepeJan De BleeckerRudy Van Coster

Bookchapter in Current protocols in human genetics

Idiopathic inflammatory myopathies and the classical NF-kappa B complex: Current insights and implications for therapy

Kim CreusBoel De PaepeJan De Bleecker

A1 Journal Article in AUTOIMMUNITY REVIEWS

Immunohistochemical analysis of the oxidative phosphorylation complexes in skeletal muscle from patients with mitochondrial DNA encoded tRNA gene defects

Boel De PaepeJoél SmetM LammensS SenecaJJ MartinJan De BleeckerL De MeirleirW LissensRudy Van Coster

A1 Journal Article in JOURNAL OF CLINICAL PATHOLOGY

Progressive myoclonic epilepsy as an adult-onset manifestation of Leigh syndrome due to the m.14487T>C mutation in ND6

Sara SenecaBart DermautPatrick SantensLina DomKatrien SmetsLuc CeulemansJoél SmetBoel De PaepeSimon TousseynSarah Weckhuysen et al.

Role of cytokines and chemokines in idiopathic inflammatory myopathies

Boel De PaepeKim CreusJan De Bleecker

A1 Journal Article in CURRENT OPINION IN RHEUMATOLOGY

Sneddon's syndrome

Jacques De ReuckJan De Bleecker

Bookchapter in Uncommon causes of stroke

2008

A case of 5-fluorouracil-induced peripheral neuropathy

BART WERBROUCKWENDY PAUWELSJan De Bleecker

A1 Journal Article in CLINICAL TOXICOLOGY

Chemokines in idiopathic inflammatory myopathies

Boel De PaepeKim CreusJan De Bleecker

A1 Journal Article in FRONTIERS IN BIOSCIENCE

Open-label trial of anti-TNF-alpha in dermato- and polymyositis treated concomitantly with methotrexate

GJD HENGSTMANJan De BleeckerE FEISTJ VISSINGCP DENTONMN MANOUSSAKISHS JENSENBGM VAN ENGELENFHJ VAN DEN HOOGEN

A1 Journal Article in EUROPEAN NEUROLOGY

Organophosphate and carbamate poisoning

Jan De Bleecker

Bookchapter in Neuromuscular junction disorders

Recurrent post-infectious rhabdomyolysis in muscle CPT-II deficiency caused by a novel missense mutation

Jelle van den AmeeleWilliam Van LandegemWim WuytsJan De Bleecker

A1 Journal Article in ACTA NEUROLOGICA BELGICA

Relative effects of statin therapy on stroke and cardiovascular events in men and women - Secondary analysis of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) study

L GoldsteinP AmarencoM LamoteS GilbertM MessigA CallahanM HennericiH SillesenK WelchSPARCL Investigators et al.

A1 Journal Article in Stroke

TNF alpha receptor genotype influences smoking-induced muscle-fibre-type shift and atrophy in mice

Boel De PaepeGuy BrusselleTania MaesKim CreusSophie D'hoseNele D'HaeseKen BrackeAn D'hulstGuy JoosJan De Bleecker

A1 Journal Article in ACTA NEUROPATHOLOGICA

2007

Chemokine profile of different inflammatory myopathies reflects humoral versus cytotoxic immune responses

Boel De PaepeKim CreusJan De Bleecker

A1 Journal Article in Annals of the New York Academy of Sciences

Distribution of glucocorticoid receptor alpha and beta subtypes in the idiopathic inflammatory myopathies

Jan De BleeckerBoel De PaepeVEERLE VERVAETBO ARYSKim CreusBF WERBROUCKJJ MARTIN

A1 Journal Article in NEUROMUSCULAR DISORDERS

Immunohistochemical studies of oxidative phosphorylation in skeletal muscle of patients with mitochondrial tRNA gene mutations

Boel De PaepeJoél SmetMartin LammensS SENECAJ MARTINJan De BleeckerRudy Van Coster

Neuromusculaire aspecten van statines

BART WERBROUCKJan De Bleecker

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Post-traumatic spontaneous recurrent hypothermia: a variant of Shapiro's syndrome

Dimitri HemelsoetJan De Bleecker

A1 Journal Article in EUROPEAN JOURNAL OF NEUROLOGY

TNF alpha receptor signalling influences the expression of myosin heavy chain isoforms in musculus gastrocnemius of the mouse

Boel De PaepeKim CreusSophie D'hoseGuy BrusselleJan De Bleecker

Two novel mitochondrial DNA mutations in muscle tissue of a patient with limb-girdle myopathy

A MEULEMANSBoel De PaepeJan De BleeckerJoél SmetW LISSENSRudy Van CosterL DE MEIRLEIRS SENECA

A1 Journal Article in ARCHIVES OF NEUROLOGY

Visualizing oxidative phosphorylation defects in skeletal muscle of patients with mitochondrial tRNA gene mutations using immunohistochemistry

Rudy Van CosterBoel De PaepeJoél SmetMartin LammensJ MARTINJan De BleeckerS SENECAW LISSENSL DE MEIRLEIR

2006

Effect of genetic modifiers on cerebral lesions in Fabry disease

Dimitri HemelsoetANNA VANTILBORGHJan De Bleecker

A1 Journal Article in NEUROLOGY

Expression of inhibitor kappa B-alpha in idiopathic inflammatory myopathies

Kim CreusBoel De PaepeN D'HaeseBART WERBROUCKG De ConinckJan De Bleecker

Intermediate syndrome in organophosphate poisoning

Jan De Bleecker

Bookchapter in Toxicology of organophosphate and carbamate compounds

Intracerebral haemorrhage in CADASIL. A case report

BF WERBROUCKJan De Bleecker

A1 Journal Article in ACTA NEUROLOGICA BELGICA

Khat chewing can cause stroke

IRIS VANWALLEGHEMPHYLLIS VANWALLEGHEMJan De Bleecker

A1 Journal Article in CEREBROVASCULAR DISEASES

MFN2 mutation distribution and genotype/phenotype correlation in Charcot-Marie-Tooth type 2

Kristien VerhoevenKG CLAEYSS ZUCHNERJM SCHRODERJ WEISC CEUTERICKA JORDANOVAE NELISEls De VriendtM VAN HUL et al.

A1 Journal Article in BRAIN

Potential therapeutic targets for idiopathic inflammatory myopathies

Jan De BleeckerKim CreusBoel De Paepe

A1 Journal Article in DRUG NEWS & PERSPECTIVES

Role of tumour necrosis factor-alpha receptor p75 in cigarette smoke-induced pulmonary inflammation and emphysema

An D'hulstKen BrackeTania MaesJan De BleeckerRomain PauwelsGuy JoosGuy Brusselle

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

The distribution of IkappaBalpha in inflammatory myopathies

Jan De BleeckerKim CreusN D'HAESEBART WERBROUCKG DE CONINCKBoel De Paepe

2005

Alpha-chemokine receptors CXCR1-3 and their ligands in idiopathic inflammatory myopathies

Boel De PaepeKRISTEL DE KEYZERJJ MARTINJan De Bleecker

A1 Journal Article in ACTA NEUROPATHOLOGICA

Bespreking Nederlandse richtlijn 'Polyneuropathie', vanuit Vlaams oogpunt

Jan De Bleecker

A2 Journal Article in TIJDSCHRIFT VOOR NEUROLOGIE EN NEUROCHIRURGIE

Distribution of glucocorticoid receptor subtypes in inflammatory myopathy

Jan De BleeckerBoel De PaepeV VERVAETBO ARYSNele D'Haese

How to approach the patient with muscular symptoms in the general neurological practice?

Jan De Bleecker

A1 Journal Article in ACTA NEUROLOGICA BELGICA

Localization of glucocorticoid receptor alpha and beta subtypes in inflammatory myopathy

Boel De PaepeVEERLE VERVAETBO ARYSNele D'HaeseJan De Bleecker

Multiple neurological syndromes during Hodgkin lymphoma remission

BART WERBROUCKV MEIREJan De Bleecker

A1 Journal Article in ACTA NEUROLOGICA BELGICA

Neuro-imaging: uw diagnose?

Jan De BleeckerV Vervaet

Editorial material

Reversible visual deficit and corpus callosum lesions due to metronidazole toxicity

Jan De BleeckerBart LeroyVeronique I Meire

A1 Journal Article in EUROPEAN NEUROLOGY

The genetic causes of basal ganglia calcification, dementia, and bone cysts DAP12 and TREM2

HH KlunemannH RidhaL MagyJR WherrettDimitri HemelsoetRW KeenJan De BleeckerMN RossorJ MarienhagenHE Klein et al.

A1 Journal Article in NEUROLOGY

β-chemokine receptor expression in idiopathic inflammatory myopathies

Boel De PaepeJan De Bleecker

A1 Journal Article in MUSCLE & NERVE

2004

Ataxia oculomotor apraxia I

Juliaan LeroyF ROELENSM DE RAMMELAERERudy Van CosterJan De Bleecker

Centrale en perifere neurologische toxiciteit door metronidazol

Françoise MeireBart LeroyJan De Bleecker

A2 Journal Article in TIJDSCHRIFT VOOR NEUROLOGIE EN NEUROCHIRURGIE

Centrale en perifere neurotoxiciteit door metronidazol

V MEIREB LEROYJan De Bleecker

A3 Journal Article in Tijdschr Neurol Neurochir

Expression and distribution of the nitric oxide synthases in idiopathic inflammatory myopathies

Boel De PaepeGZ RACZJM SCHRODERJan De Bleecker

A1 Journal Article in ACTA NEUROPATHOLOGICA

Localization of the alpha-chemokine SDF-1 and its receptor CXCR4 in idiopathic inflammatory myopathies

Boel De PaepeJM SCHRODERJJ MARTINGZ RACZJan De Bleecker

A1 Journal Article in NEUROMUSCULAR DISORDERS

Necrotizing myopathy with microvascular deposition of the complement membrane attack complex

Jan De BleeckerVEERLE VERVAETP VAN DEN BERGH

A1 Journal Article in CLINICAL NEUROPATHOLOGY

New mutation in first Belgian cases of Nasu-Hakola disease

Dimitri HemelsoetJ PALONEVAJan De Bleecker

Potentieel reversibele autoimmune limbische encephalopathie met antilichamen tegen neuronale kaliumkanalen

Jan De Bleecker

A3 Journal Article in Tijdschr Neurol Neurochir

Reversible orofacial dyskinesia after ofloxacin treatment

Jan De BleeckerVL VERVAETA DE SARRO

A1 Journal Article in MOVEMENT DISORDERS

The idiopathic inflammatory myopathies

Jan De Bleecker

Work-up of the patient with a hereditary myopathy

Jan De Bleecker

2003

A pure sensorimotor stroke due to cervical vertebral artery occlusion

MATTI DE CLERCKKoen PaemeleireEric AchtenP VAN LANGENHOVENJan De BleeckerJacques De Reuck

A1 Journal Article in ACTA NEUROLOGICA BELGICA

Alpha-chemokines and Th1 mediated inflammation in polymyositis and inclusion body myositis

Jan De BleeckerBoel De PaepeKRISTEL DE KEYZER

Localization of Th1 associated chemokines in inflammatory myopathies

Jan De BleeckerBoel De PaepeK De Keyser

Localization of Th1 associated chemokines in inflammatory myopathies

Jan De BleeckerBoel De Paepe

Recurrent spontaneous hypothermia and a traumatic lesion of the corpus callosum: a variant of Shapiro's syndrome?

Dimitri HemelsoetJan De Bleecker

Reversible corpus callosum lesions due to metronidazole therapy

V MEIREJan De Bleecker

The idiopathic inflammatory myopathies

Jan De BleeckerBoel De Paepe

Bookchapter in Advances in Clinical Neurosciences

epstein-Barr virus en het zenuwstelsel

Kristel De KeyzerJan De Bleecker

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

2002

An unusual cause of stroke with right sensorimotor hemisyndrome

M DE CLERCKKoen PaemeleireJan De BleeckerEric AchtenP VAN LANGENHOVENJacques De Reuck

An unusual cause of stroke with right sensorimotor hemisyndrome

M DE CLERCKKoen PaemeleireJan De BleeckerEric AchtenP VAN LANGENHOVENJacques De Reuck

Beta chemokines and their receptors in inflammatory myopathies

Jan De BleeckerBoel De PaepeG RaczJM Schröder

CXCR4 chemokine receptor density in inflammatory myopathies

V MEIREJan De BleeckerBoel De PaepeJ SCHRODER

Chemokine receptors in inflammatory myopathy

Boel De PaepeV MEIREG RACZJM SCHRODERJan De Bleecker

Differential expression of chemokines in inflammatory myopathies

Jan De BleeckerBoel De PaepeIRIS VANWALLEGHEMJM Schröder

A1 Journal Article in NEUROLOGY

Differential organ involvement in peroxisomal disorders

Frank RoelsMarianne DepreterMarisa GirosSylvia StocklerHannah MandelD TroostBoel De PaepeJan De BleeckerMarc D'HoogheChristian Nuttin et al.

Expression of MCP-1 and its receptors CCR2 and CCR4 in the inflammatory myopathies

Jan De BleeckerBoel De PaepeJM Schröder

Immunolocalization of the chemokine CXCL12 and its receptor CXCR4 in the inflammatory myopathies

Boel De PaepeJan De BleeckerG RACZJM SCHROEDER

Immunopathogenesis of the idiopathic inflammatory myopathies.

Jan De Bleecker

2001

Blue native polyacrylamide gel electrophoresis: A powerful tool in diagnosis of oxidative phosphorylation defects

Rudy Van CosterJoél SmetEdith GeorgeL DE MEIRLEIRS SENECAJ VAN HOVEG SEBIREHelene VerhelstJan De BleeckerB VAN VLEM et al.

A1 Journal Article in PEDIATRIC RESEARCH

Chemokines in inflammatory myopathies

Jan De BleeckerBoel De PaepeJ SCHRODER

De neurologische importziekte in de lage landen: neuro-behçet.

N LIBBRECHTJan De BleeckerLuc CrevitsJacques De Reuck

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Differential expression of beta-chemokines in inflammatory myopathies

Jan De BleeckerBoel De PaepeJM Schröder

Differential regional cerebral uptake of F-18-fluoro-2-deoxy-D-glucose in Alzheimer's disease and frontotemporal dementia at initial diagnosis

Patrick SantensJan De BleeckerPatrick GoethalsKarel StrijckmansIgnace LemahieuGuido SlegersRudi DierckxJacques De Reuck

A1 Journal Article in EUROPEAN NEUROLOGY

Immunolocalization of Fas and Fas-ligand in inflammatory myopathies.

Jan De BleeckerVI MEIREIE VAN WALLEGHEMIM GROESSENSJM SCHRODER

A1 Journal Article in ACTA NEUROPATHOLOGICA

Mag men patiënten met multiple sclerose of met demyeliniserende polyradiculoneuropathie vaccineren tegen griep?

I VAN WALLEGHEMJan De Bleecker

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Regenerating soleus and extensor digitorum longus muscles of the rat show elevated levels of TNF-alpha and its receptors, TNFR-60 and TNFR-80.

E ZADORL MENDLERV TAKACSJan De BleeckerF WUYTACK

A1 Journal Article in MUSCLE & NERVE

2000

Cobalt-55 positron emission tomography in late-onset epileptic seizures after thrombo-embolic middle cerebral artery infarction

Jacques De ReuckKristl VonckPatrick SantensPaul BoonJan De BleeckerKarel StrijckmansIgnace Lemahieu

A1 Journal Article in JOURNAL OF THE NEUROLOGICAL SCIENCES

Cobalt-55 positron emission tomography in late-onset epileptic seizures after thrombo-embolic middle cerebral artery infarction.

Jacques De ReuckKristl VonckPatrick SantensPaul BoonJan De BleeckerKoen StrijckmansIgnace Lemahieu

Inflammatoire myopathieën.

Jan De Bleecker

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Successful immunoglobulin treatment in a patient with neuromyotonia.

G ALESSIJacques De ReuckJan De BleeckerS VANCAYZEELE

A1 Journal Article in CLINICAL NEUROLOGY AND NEUROSURGERY

1999

Ankylosing spondylitis and multiple sclerosis. Is there an association between ankylosing spondylitis and multiple sclerosis ?

N LIBBRECHTJan De Bleecker

A1 Journal Article in ACTA CLINICA BELGICA

Cobalt-55 positron emission tomography in recurrent ischaemic stroke

Jacques De ReuckPatrick SantensJ KEPPENSJan De BleeckerKarel StrijckmansPatrick GoethalsIgnace LemahieuJ KORF

A1 Journal Article in CLINICAL NEUROLOGY AND NEUROSURGERY

Cobalt-55 positron emission tomography in recurrent ischaemic stroke

Jacques De ReuckPatrick SantensJ KEPPENSJan De BleeckerKarel StrijckmansP GOETHALSIgnace LemahieuJ KORF

Immunolocalization of Fas and Fas-ligand (Fas-L) in inflammatory myopathies

Jan De BleeckerV MeireS Pappens

Immunolocalization of Fas and Fas-ligand in inflammatory myopathies

Jan De BleeckerV MEIRES PAPPENS

Immunolocalization of tumor necrosis factor-alpha and its receptors in inflammatory myopathies.

Jan De BleeckerVI MEIREWim DeclercqEH VAN AKEN

A1 Journal Article in NEUROMUSCULAR DISORDERS

Leptomeningeal metastases from ethmoid sinus adenocarcinoma: clinico-radiological correlation

A DevosMarc LemmerlingF VanrietveldeF GovaereJan De BleeckerM BeelMarc Kunnen

A2 Journal Article in JBR-BTR

Melatonin and painful gynecomastia

Jan De BleeckerBH LamontAG VerstraeteVJ Schelfhout

A1 Journal Article in NEUROLOGY

Neuro-Behcet's disease

N LIBBRECHTJan De BleeckerJacques De Reuck

Positron emission tomography in Alzheimer's disease and frontotemporal dementia at initial diagnosis

Patrick SantensJan De BleeckerP GOETHALSK STRIJKMANSIgnace LemahieuG SLEGERSR DIERICKXJacques De Reuck

Progressive dysarthria - Case reports and a review of the literature.

Patrick SantensJohn Van BorselE FONCKEV MEIREH MERKXJan De BleeckerJacques De Reuck

A1 Journal Article in DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

1998

Circulating intercellular adhesion molecule-1 and E-selectin in acute ischemic stroke

Jan De BleeckerIlse CoulierCarmen FleuricnkJacques De Reuck

A2 Journal Article in JOURNAL OF STROKE AND CEREBROVASCULAR DISEASES

Congenital myasthenic syndromes due to null mutations in acethylcholine receptor zeta subunit gene in Turkish kinships

B ANLARK OHNOE OZDIRIMJ BRENGMANJan De BleeckerA ENGEL

Immunolocalization of tumor necrosis factor-alpha and its receptors in inflammatory myopathies

Jan De BleeckerVI MeireW DeclercqElisabeth Van Aken

Myasthenic syndromes in Turkish kinships due to mutations in the acetylcholine receptor.

K OHNOB ANLARE OZDIRIMJM BRENGMANJan De BleeckerAG ENGEL

A1 Journal Article in ANNALS OF NEUROLOGY

Quinidine prevents paraoxon-induced necrotizing myopathy in rats.

Jan De BleeckerVI MEIRES PAPPENS

A1 Journal Article in NEUROTOXICOLOGY

Riluzol bij amyotrofe lateraalsclerose

Jan De BleeckerM BOGAERT

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Thrombolyse bij het acuut ischemisch cerebrovasculair accident.

Jacques De ReuckJan De Bleecker

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

1997

Frameshift and splice-site mutations in acetylcholine receptor (AChR) epsilon subunit gene in five Turkish kinships with congenital myasthenic syndromes (CMS)

K OHNOB ANLARE OZDIRIMJ BRENGMANJan De BleeckerA ENGEL

Immunopathogenesis of inflammatory myopathies

Jan De Bleecker

Localization of tumor necrosis factor-alpha (TNF-alpha) and its receptors in inflammatory myopathies.

Jan De BleeckerE VANAKENV MEIRE

A1 Journal Article in ACTA NEUROLOGICA BELGICA

Localization of tumor necrosis factor-alpha and its receptors in inflammatory myopathies

Jan De BleeckerElisabeth Van AkenV MEIRE

Muscle cramps and fasciculations

V MEIREJan De Bleecker

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Severe malathion poisoning - Invited reply.

Jan De BleeckerDirk Vogelaers

A1 Journal Article in Journal of toxicology. Clinical toxicology

Variability within the so-called desmin storage myopathy

Jan De BleeckerG MOOREK DOROVINI-ZISA EISENA ENGEL

1996

Localization of tumor necrosis factor-alpha and its receptors in inflammatory myopathies

Jan De BleeckerElisabeth Van AkenV MEIRE

Localization of tumor necrosis factor-alpha and its receptors in inflammatory myopathies

Jan De BleeckerElisabeth Van AkenV MEIRE

Multiple system organ failure: Link to intermediate syndrome indirect.

Jan De Bleecker

A1 Journal Article in Journal of toxicology. Clinical toxicology

Myasthenia gravis and sarcoidosis: Report of 2 cases.

Jan De BleeckerL VANAKENW VANLANDEGEMG VANDENABEELEClaude Cuvelier

A1 Journal Article in EUROPEAN NEUROLOGY

Myasthenia gravis and sarcoidosis: report of two cases

Elisabeth Van AkenW VAN LANDEGEMG VAN DEN ABEELEClaude CuvelierJan De Bleecker

Peripheral lymphoid tissue-like adhesion molecule expression in nodular infiltrates in inflammatory myopathies

Jan De BleeckerA ENGELE BUTCHER

Peripheral lymphoid tissue-like adhesion molecule expression in nodular infiltrates in inflammatory myopathies.

Jan De BleeckerAG ENGELEC BUTCHER

A1 Journal Article in NEUROMUSCULAR DISORDERS

Serum levels of soluble ICAM-1 and E-selectin in acute stroke

I COULIERC FLEURINCKJacques De ReuckJan De Bleecker

1995

Immunocytochemical study of CD45 Tcell isoforms in inflammatory myopathies.

Jan De BleeckerAG ENGEL

A1 Journal Article in AMERICAN JOURNAL OF PATHOLOGY

Immunocytochemistry of muscle cytoskeletal proteins in acid maltase deficiency.

Jan De BleeckerAG ENGEL

A1 Journal Article in MUSCLE & NERVE

Lymphoid tissue-like pattern of adhesion molecule expression in nodular infiltrates in inflammatory myopathies

Jan De BleeckerA ENGELE BUTCHER

THE INTERMEDIATE SYNDROME IN ORGANOPHOSPHATE POISONING - AN OVERVIEW OF EXPERIMENTAL AND CLINICAL OBSERVATIONS.

Jan De Bleecker

A1 Journal Article in Journal of toxicology. Clinical toxicology

The differential diagnosis of idiopalhic inflammatory myopathies

Jan De Bleecker

The intermediate syndrome: a prospective study

Jan De Bleecker

1994

A DOUBLE-BLIND-STUDY OF NEUROTROPIN IN PATIENTS WITH ACUTE ISCHEMIC STROKE.

Jacques De ReuckD DECOOP VANDERDONCKTA DALLENGAW CEUSTERSJP KALALAK DEMEULEMEESTERJ ABDULLAHPatrick SantensJ HUYBRECHTS et al.

A1 Journal Article in ACTA NEUROLOGICA SCANDINAVICA

Acute and subacute organophospate poisoning in the rat.

Jan De BleeckerD LISONK VANDENABEELEJan WillemsJacques De Reuck

A1 Journal Article in NEUROTOXICOLOGY

Classificatie en histopathologie van vasculitiden.

Marleen PraetFilip De KeyserJ NAEYAERTJ KEPSRaymond VanholderJan De BleeckerEric Veys

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

De diagnose van specifieke inflammatoire myopathieën

Jan De Bleecker

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Electromyography in relation to end-plate acetylcholinesterase in rats poisoned by different organophosphates.

Jan De BleeckerK VANDENABEELEJacques De Reuck

A1 Journal Article in NEUROTOXICOLOGY

Expression of CD45 isoforms on T cells in inflammatory myopathies

Jan De BleeckerA ENGEL

Expression of cell adhesion molecules in inflammatory myopathies and Duchenne dystrophy

Jan De BleeckerA ENGEL

A2 Journal Article in J. Neuropathol. Exp.Neurol., 53

Expression of cell adhesion molecules in myopathies

Jan De BleeckerA ENGEL

Expression of cell adhesion molecules in myopathies

Jan De BleeckerA ENGEL

Expression of cell-adhesion molecules in inflammatory myopathies and Duchenne dystrophy.

Jan De BleeckerAG ENGEL

A1 Journal Article in JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Localization of dystrophin and beta-spectrin in vacuolar myopathies.

Jan De BleeckerA ENGEL

Myopathy with desmin excess

Jan De BleeckerA ENGEL

Myopathy with desmin excess

Jan De BleeckerA ENGEL

Oculo-palatal myoclonus

Luc CrevitsJan De BleeckerJacques De Reuck

Patterns of abnormal protein expression in target formations and unstructured cores

B ERTLJan De BleeckerA ENGEL

Similarities and differences between target formations and the ledions in desmin storage myopathy

B ERTLJan De BleeckerA ENGEL

The intermediate syndrome in organo-phosphate poisoning: experimental and clinical observations

Jan De Bleecker

Variability within the so-called desmin storage myopathy

Jan De BleeckerA ENGEL

1993

Dystrophin and B-spectrin expression in vacuolar myopathies

Jan De BleeckerA ENGELJ WINKELMANN

A2 Journal Article in American Journal Pathol., 143, pp. 1200-1208

INTERMEDIATE SYNDROME - PROLONGED CHOLINESTERASE INHIBITION.

Jan De Bleecker

A1 Journal Article in Journal of toxicology. Clinical toxicology

INTERMEDIATE SYNDROME IN ORGANOPHOSPHORUS POISONING - A PROSPECTIVE-STUDY.

Jan De BleeckerK VANDENNEUCKERFrancis Colardyn

A1 Journal Article in CRITICAL CARE MEDICINE

Immunolocalization of dystrophine, beta-spectrin and laminin in vascular myopathies.

Jan De BleeckerA ENGEL

LOCALIZATION OF DYSTROPHIN AND BETA-SPECTRIN IN VACUOLAR MYOPATHIES.

Jan De BleeckerAG ENGELJC WINKELMANN

A1 Journal Article in AMERICAN JOURNAL OF PATHOLOGY

Neurologische aspecten van intoxicaties met organofosfaat esters

Jan De BleeckerJacques De ReuckJan Willems

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

1992

Are Wistar rats not susceptible to organophosphate-induced delayed neurotoxicity.

Jan De BleeckerKG VANDENABEELEJL WILLEMSJacques De Reuck

A1 Journal Article in RESEARCH COMMUNICATIONS IN CHEMICAL PATHOLOGY AND PHARMACOLOGY

INTERMEDIATE SYNDROME DUE TO PROLONGED PARATHION POISONING.

Jan De BleeckerDirk VogelaersC CEUTERICKK VANDENNEUCKERJan WillemsJacques De Reuck

A1 Journal Article in ACTA NEUROLOGICA SCANDINAVICA

Neurological aspects of organophosphate poisoning.

Jan De BleeckerJacques De ReuckJan Willems

A1 Journal Article in CLINICAL NEUROLOGY AND NEUROSURGERY

PROLONGED TOXICITY WITH INTERMEDIATE SYNDROME AFTER COMBINED PARATHION AND METHYL PARATHION POISONING.

Jan De BleeckerJan WillemsK VANDENNEUCKERJacques De ReuckDirk Vogelaers

A1 Journal Article in Journal of toxicology. Clinical toxicology

THE INTERMEDIATE SYNDROME IN ORGANOPHOSPHATE POISONING - PRESENTATION OF A CASE AND REVIEW OF THE LITERATURE.

Jan De BleeckerK VANDENNEUCKERJan Willems

A1 Journal Article in Journal of toxicology. Clinical toxicology

TRANSIENT OPSOCLONUS IN ORGANOPHOSPHATE POISONING.

Jan De Bleecker

A1 Journal Article in ACTA NEUROLOGICA SCANDINAVICA

Transesophageal echo-Doppler in patients suspected of a cardiac source of peripheral emboli

J VandenbogaerdeJan De BleeckerD DecooKatrien FrancoisB CambierJ-M BergenC VandermerschJacques De ReuckDenis Clement

A1 Journal Article in EUROPEAN HEART JOURNAL

UNUSUAL CT AND MRI FINDINGS IN PALATAL MYOCLONUS.

Jan De BleeckerW VANLANDEGEMLuc CrevitsJacques De Reuck

A1 Journal Article in ACTA NEUROLOGICA SCANDINAVICA

VARIABLE INVOLVEMENT OF RAT SKELETAL-MUSCLES IN PARAOXON-INDUCED NECROTIZING MYOPATHY.

Jan De BleeckerKG VANDENABEELEJacques De Reuck

A1 Journal Article in RESEARCH COMMUNICATIONS IN CHEMICAL PATHOLOGY AND PHARMACOLOGY

1991

HISTOLOGICAL AND HISTOCHEMICAL-STUDY OF PARAOXON MYOPATHY IN THE RAT.

Jan De BleeckerJan WillemsJacques De ReuckPatrick SantensD LISON

A1 Journal Article in ACTA NEUROLOGICA BELGICA

Myopathies associated with AIDS

Jan De BleeckerJacques De ReuckK VAN DEN ABEELE

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

PERSISTING CHLOROQUINE-INDUCED MYASTHENIA.

Jan De BleeckerJacques De ReuckJozef QuatackerFrançoise Meire

A1 Journal Article in ACTA CLINICA BELGICA

Pancreatic encephalopathy: a case report and review of the literature

Paul BoonJacques De ReuckEric AchtenJan De Bleecker

A1 Journal Article in CLINICAL NEUROLOGY AND NEUROSURGERY

Pathogenesis of organophosphate-induced myopathy

Jan De BleeckerK VAN DEN ABEELEJacques De ReuckJ WILLEMS

Postsynaptic neuromuscular dysfunction in organophosphate induced intermediate syndrome

V De WildeDirk VogelaersFrancis ColardynGuy VanderstraetenK Van Den NeuckerJan De BleeckerJacques De ReuckM Van Den Heede

A1 Journal Article in KLINISCHE WOCHENSCHRIFT

1990

A prospective and double blind study on neurotopin in patients with ischemic stroke

Jacques De ReuckD DecooP VanderdoncktA DallengaW CeustersJean-Pierre Kalala OkitoJan De BleeckerE TackI TackPaul Boon

Combined intracarotid chemotherapy and osmotic blood-brain barrier disruption

H VermeulenGeorges RollyJ DevulderJ HaemersJan De Bleecker

Cytomorphometric DNA determination in human meningiomas

G DE LA MEILLEUREJacques De ReuckJan De BleeckerP NAESSENS

Influence of neurotomy on paraoxon-induced myopathy in rats

K VAN DEN ABEELEJan De BleeckerJacques De ReuckJ WILLEMS

Oculo-palatal myoclonus after basal meningitis

Jan De BleeckerA DALLENGAJacques De Reuck

Ossification of the cervical posterior longitudinal ligament with severe myelopathy and fatal outcome

D MeireJan De BleeckerJ VallaeysE Van de Velde

A4 Journal Article in JOURNAL BELGE DE RADIOLOGIE (1924) = BELGISCH TIJDSCHRIFT VOOR RADIOLOGIE (1924)

Persisting chloroquine-induced myasthenia

Jan De BleeckerF MEIREJacques De Reuck

Study of the different forms of neuro-muscular manifestations associated with organophosphate poisoning

D LISONJan De BleeckerJ WILLEMS

A3 Journal Article in Ann Med Milit Belg

Transoesophageal echocardiography and doppler for detection of a cardiac source of embolus

Jan De BleeckerJ VANDENBOGAERDED DECOOJacques De Reuck

Transoesophageal echocardiography and doppler for detection of a cardiac source of embolus

Jan De BleeckerJ VANDENBOGAERDED DECOOJacques De Reuck

1989

A prospective and double blind study on neurotropin in patients with ischemic stroke

Jacques De ReuckW CEUSTERSA DALLENGAJ KALALAD DECOOE TACKJan De BleeckerPaul Boon

Early effects of industrial toxic agents on the central nervous system

Jan De BleeckerM VANHOORNEJacques De Reuck

A3 Journal Article in cahiers voor arbeidsgeneeskunde

Influence of ACTH4-10 on the tenotomized and denervated rat gastrocnemius muscle. A combined physiological and morphological study

Jan De BleeckerL CEULEMANSJacques De ReuckG DE LA MEILLEURE

Neuropathological characteristics of paraoxon and fenthion myopathy

Jan De BleeckerS DE PRAETEREPatrick SantensJ WILLEMSJacques De Reuck

Neuropathological characteristics of paraoxon-induced myopathy in the rat

Jan De BleeckerJacques De ReuckPatrick SantensS DE PRAETEREJ WILLEMS

Pancreatic encephalopathy

Paul BoonJacques De ReuckEric AchtenJan De Bleecker

The hyperventilation syndrome as the initial manifestation of neurological disorders

Jan De BleeckerJ WILLEMSJacques De ReuckPatrick SantensD LISON

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

1988

Cervical myelopathy due to ossification of the posterior longitudinal ligament

Jan De BleeckerJacques De ReuckD MEIREV VAN VELTHOVEN

Cervical myelopathy due to ossification of the posterior longitudinal ligament

Jan De BleeckerD MEIREJacques De ReuckV VAN VELTHOVEN

Cervical myelopathy due to ossification of the posterior longitudinal ligament

Jan De BleeckerJacques De ReuckD MEIREV VAN VELTHOVEN

Dermatomyositis with paracrystalline inclusions and polymicrogyria in two sisters

Jan De BleeckerJacques De ReuckJ MARTINC CEUTERICKDietbrand CartonJuliaan Leroy

Het hyperventilatiesyndroom als initiele uiting van neurologische aandoeningen

Jan De BleeckerJacques De ReuckL ALGOEDL CEULEMANS

Influence of ACTH4-10 on the tenotomized and denervated rat gastrocnemius muscle: a combined physiological and morphological study

Jan De BleeckerL CEULEMANSJacques De ReuckG DE LA MEILLEURE

Steroid treatment in primary intracerebral hemorrhage

Jacques De ReuckJan De BleeckerK REYNTJENS

1987

Mitotic activity in cerebrospinal fluid cells

Jacques De ReuckP VANDERDONCKTJan De BleeckerH MAREELSV VANDEWALLE

Polymicrogyria and dermatomyositis in two sisters

Jacques De ReuckDietbrand CartonJ MARTINC CEUTERICKJan De BleeckerJuliaan Leroy

The clinical picture of Binswanger's chronic progressive subcortical leuko-encephalopathy, a retrospective analysis of 33 cases

Jan De BleeckerJacques De Reuck

The syndrome of the anterior choroidal artery

Jan De BleeckerJacques De ReuckG VINGERHOETSW CEUSTERSEvert Thiery

1986

Influence of isaxonine on reinnervation of rat gastrocnemius muscle

Jacques De ReuckJan De BleeckerW DE COSTERJ BLANCQUAERT

Influence of isaxonine on reinnervation of rat gastrocnemius muscle

Jacques De ReuckJan De BleeckerW DE COSTERJ BLANCQUAERT

Influence of isaxonine on target phenomenon, muscle fibre size and neuromuscular junctions in the tenotomized and denervated gastrocnemius muscle of the rat

Jan De BleeckerW DE COSTERJacques De ReuckJ BLANCQUAERT

1985

Comparison of incidence and cause of stroke in young, middle-aged and old people

Jacques De ReuckJan De BleeckerW DE COSTER

1984

Prognosis of carbon disulfide intoxication, preliminary findings

M VANHOORNEA GELDHOFJan De Bleecker

Organophosphates and health. The intermediate syndrome. Imperial College Press, London, UK, 2001, pp. 141-158.

Jan De Bleecker

Uncommon causes of stroke. Sneddon's syndrome. Cambridge University Press, Cambridge, UK, 2001, pp. 258-265.

Jan De BleeckerJacques De Reuck