Research Explorer

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Researcher

Jakob Bouton

Awards & Distinctions

16 Results

2021

6‐methyl‐7‐aryl‐7‐deazapurine nucleosides as anti‐trypanosoma cruzi agents : structure‐activity relationship and in vivo efficacy

Cai LinLudmila Ferreira de Almeida FiuzaCamila Cardoso SantosDaniela Ferreira NunesOtacílio Cruz MoreiraJakob BoutonIzet KaralicLouis MaesGuy CaljonFabian Hulpia et al.

A1 Journal Article in CHEMMEDCHEM

Homoazanucleoside, purine nucleoside and hamamelitannin analogues : towards new therapeutics for infectious diseases

Jakob BoutonSerge Van Calenbergh

Revisiting pyrazolo[3,4-d]pyrimidine nucleosides as anti-trypanosoma cruzi and antileishmanial agents

Jakob BoutonLudmila Ferreira de Almeida FiuzaCamila Cardoso SantosMaria Angela MazzarellaMaria de Nazaré Correia SoeiroLouis MaesIzet KaralicGuy CaljonSerge Van Calenbergh

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and evaluation of 3′-fluorinated 7-deazapurine nucleosides as antikinetoplastid agents

Jakob BoutonArno Furquim d'AlmeidaLouis MaesGuy CaljonSerge Van CalenberghFabian Hulpia

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and evaluation of a collection of purine-like C-nucleosides as antikinetoplastid agents

Jakob BoutonLouis MaesIzet KaralicGuy CaljonSerge Van Calenbergh

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

2020

6-O-alkylated 7-deazainosine nucleoside analogues : discovery of potent and selective anti-sleeping sickness agents

Fabian HulpiaJakob BoutonGustavo D. CampagnaroIbrahim A. AlfayezDorien MabilleLouis MaesHarry P. de KoningGuy CaljonSerge Van Calenbergh

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Radiosynthesis, in vitro and preliminary biological evaluation of [F-18]2-amino-4-((2-((3-fluorobenzyl)oxy)benzyl)(2-((3-(fluoromethyl)benzyl)oxy)benzyl)amino) butanoic acid, a novel alanine serine cysteine transporter 2 inhibitor-based positron emission tomography tracer

Tristan BaguetJakob BoutonJonas JanssensGlenn PauwelynJeroen VerhoevenBenedicte DescampsSerge Van CalenberghChristian VanhoveFilip De Vos

A1 Journal Article in JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Sydnone ribosides as a platform for the synthesis of pyrazole C-nucleosides : a unified synthesis of formycin B and pyrazofurin

Jakob BoutonSerge Van CalenberghJan Hullaert

A1 Journal Article in ORGANIC LETTERS

2019

3’-Deoxy-3’-fluoro-7-deazapurine nucleosides : synthesis and evaluation against kinetoplastid parasites

Jakob BoutonFabian HulpiaLouis MaesGuy CaljonSerge Van Calenbergh

Novel pyrazolo[3,4-d]pyrimidine nucleosides : promising hits for Chagas disease and Leishmaniasis

Jakob BoutonFabian HulpiaSerge Van CalenberghGuy CaljonLouis Maes

Synthesis and biological evaluation of 1’-N-homoazanucleosides : discovery of a 5’-methylthioadenosine analogue with antitrypanosomal activity

Jakob BoutonSerge Van Calenbergh

Synthesis and evaluation of 3’-deoxy-3’-fluoro-7-deazapurine nucleosides as antikinetoplastid agents

Jakob BoutonFabian HulpiaGuy CaljonLouis MaesSerge Van Calenbergh

2018

Synthesis of pyrrolidine-based hamamelitannin analogues as quorum sensing inhibitors in Staphylococcus aureus

Jakob BoutonKristof Van HeckeReuven RasoolySerge Van Calenbergh

A1 Journal Article in BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of pyrrolidine-based hamamelitannin analogues in the search for potentiators for antibiotics against Staphylococcus aureus

Jakob BoutonSerge Van Calenbergh

2017

Efficient diastereoselective synthesis of a new class of azanucleosides : 2'-homoazanucleosides

Jakob BoutonKristof Van HeckeSerge Van Calenbergh

A1 Journal Article in TETRAHEDRON

2016

Synthesis of 1’-N-homoazanucleosides as potential transition state analogues and antiviral agents

Jakob BoutonSerge Van Calenbergh