Research Explorer

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Researcher

Isabelle Desombere

Awards & Distinctions

69 Results

2021

A role for B cells to transmit hepatitis C virus infection

Isabelle DesombereFreya Van HoutteAliasghar Farhoudi MoghadamLieven VerhoyeCaroline BuysschaertYvonne GijbelsSibyl CouventW SwinnenHans Van VlierbergheAndré Elewaut et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

2018

Development and characterization of a human monoclonal antibody targeting the N-terminal region of hepatitis C virus envelope glycoprotein E1

Ahmed Atef Ahmed Abouzeid MesalamIsabelle DesombereAliasghar Farhoudi MoghadamFreya Van HoutteLieven VerhoyeJonathan BallJean DubuissonSteven KH FoungArvind H PatelMats AA Persson et al.

A1 Journal Article in VIROLOGY

2017

A novel neutralizing human monoclonal antibody broadly abrogates hepatitis C virus infection in vitro and in vivo

Isabelle DesombereAhmed Atef Ahmed Abouzeid MesalamRichard A UrbanowiczFreya Van HoutteLieven VerhoyeZhen-Yong KeckAliasghar Farhoudi MoghadamKoen VercauterenKarin WeeningThomas F Baumert et al.

A1 Journal Article in ANTIVIRAL RESEARCH

Development and characterization of a human monoclonal antibody for prevention of HCV recurrence in liver transplant patients

Ahmed Atef Ahmed Abouzeid MesalamIsabelle DesombereRichard UrbanowiczDaniel X JohanssonKoen VercauterenAliasghar Farhoudi MoghadamFreya Van HoutteLieven VerhoyeMats PerssonJonathan Ball et al.

2016

Heads or tails : genotyping of hepatitis C virus concerning the 2k/1b circulating recombinant form

WIM SCHUERMANSHans OrlentIsabelle DesomberePatrick DescheemaekerHans Van VlierbergheAnja GeertsXavier VerhelstMarijke ReyndersElizaveta Padalko

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Monoclonal anti-envelope antibody AP33 protects humanized mice against a patient-derived hepatitis C virus challenge

Isabelle DesombereSamira Fafi-KremerFreya Van HouttePatrick PessauxAliasghar Farhoudi MoghadamLaura HeydmannLieven VerhoyeSarah ColeJane A McKeatingGeert Leroux-Roels et al.

A1 Journal Article in HEPATOLOGY

2015

A broadly neutralizing monoclonal antibody targeting hepatitis C virus prevents viral infection in vitro and in uPA/SCID mice with humanized liver

Ahmed Atef Ahmed Abouzeid MesalamIsabelle DesombereRichard UrbanowiczDaniel X JohanssonKoen VercauterenAliasghar Farhoudi MoghadamFreya Van HoutteLieven VerhoyeKarin WeeningMats Persson et al.

A broadly neutralizing monoclonal antibody targeting hepatitis C virus prevents viral infection in vitro and in uPA/SCID mice with humanized liver

Ahmed Atef Ahmed Abouzeid MesalamIsabelle DesombereRichard UrbanowiczDaniel X JohanssonAliasghar Farhoudi MoghadamFreya Van HoutteLieven VerhoyeMats PerssonJonathan BallGeert Leroux-Roels et al.

A broadly neutralizing monoclonal antibody targeting hepatitis C virus prevents viral infection in vitro and in uPA/SCID mice with humanized liver

Ahmed Atef Ahmed Abouzeid MesalamIsabelle DesombereRichard UrbanowiczDaniel X JohanssonAliasghar Farhoudi MoghadamFreya Van HoutteLieven VerhoyeMats PerssonJonathan BallGeert Leroux-Roels et al.

2013

Polyfunctional CD4⁺ T cell responses in HIV-1 infected viral controllers compared with those in healthy recipients of an adjuvanted polyprotein HIV-1 vaccine

Eva Van BraeckelIsabelle DesombereFrédéric ClementLinos VandekerckhoveChris VerhofstedeDirk VogelaersGeert Leroux-Roels

A1 Journal Article in VACCINE

2012

A human monoclonal antibody targeting scavenger receptor class B type I precludes hepatitis C virus infection and viral spread in vitro and in vivo

Philip MeulemanMaria Teresa CataneseLieven VerhoyeIsabelle DesombereAliasghar Farhoudi MoghadamChristopher T JonesTimothy SheahanKatarzyna GrzybRiccardo CorteseCharles M Rice et al.

A1 Journal Article in HEPATOLOGY

Validation of an enzyme-linked immunosorbent assay for the quantification of human IgG directed against the repeat region of the circumsporozoite protein of the parasite Plasmodium falciparum.

Frédéric ClementVincent DewarEva Van BraeckelIsabelle DesombereMarianne DewerchinChristine SwysenMarie-Ange DemoitiéErik JongertJoe CohenGeert Leroux-Roels et al.

A1 Journal Article in MALARIA JOURNAL

2011

In vivo evaluation of the cross-genotype neutralizing activity of polyclonal antibodies against hepatitis C virus

Philip MeulemanJens BukhLieven VerhoyeAliasghar Farhoudi MoghadamTHOMAS VANWOLLEGHEMRichard Y WangIsabelle DesombereHarvey AlterRobert H PurcellGeert Leroux-Roels

A1 Journal Article in HEPATOLOGY

2010

Baseline anti-NS4a antibodies in combination with on-treatment quantitative HCV-RNA reliably identifies nonresponders to pegylated interferon-ribavirin combination therapy after 4 weeks of treatment

Hans OrlentIsabelle DesombereBettina HansenHans Van VlierbergheBart HaagmansRobert J de KnegtSolko W SchalmGeert Leroux-RoelsHarry LA Janssen

A1 Journal Article in EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Factors determining successful engraftment of hepatocytes and susceptibility to hepatitis B and C virus infection in uPA-SCID mice

THOMAS VANWOLLEGHEMLouis LibbrechtBettina E HansenIsabelle DesombereTania RoskamsPhilip MeulemanGeert Leroux-Roels

A1 Journal Article in JOURNAL OF HEPATOLOGY

HCV genotype distribution in Flanders and Brussels (Belgium): unravelling the spread of an uncommon HCV genotype 5a cluster

J VerbeeckL KwantenF D'HeygereA BeguinS MichielsIsabelle DesombereGeert Leroux-RoelsP LemeyF NevensM Van Ranst

A1 Journal Article in EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

2008

ANTI-CD81 ANTIBODIES CAN PREVENT A HEPATITIS C VIRUS INFECTION IN VIVO

Philip MeulemanJoseph HesselgesserMatthew PaulsonTHOMAS VANWOLLEGHEMIsabelle DesombereHans ReiserGeert Leroux-Roels

Anti-CD81 Antibodies Can Prevent a Hepatitis C Virus Infection In Vivo

Philip MeulemanJoseph HesselgesserMatthew PaulsonTHOMAS VANWOLLEGHEMIsabelle DesombereIlans ReiserGeert Leroux-Roels

A1 Journal Article in HEPATOLOGY

Hepatitis C virus cell-cell transmission in hepatoma cells in the presence of neutralizing antibodies

Jennifer M. TimpeZania StamatakiAdam JenningsKe HuMichelle J. FarquharHelen J. HarrisAnne SchwarzIsabelle DesombereGeert Leroux-RoelsPeter Bafe et al.

A1 Journal Article in HEPATOLOGY

Polyclonal immunoglobulins from a chronic hepatitis C virus patient protect human liver-chimeric mice from infection with a homologous hepatitis C virus strain

THOMAS VANWOLLEGHEMJ BUKHPhilip MeulemanIsabelle DesombereJC MEUNIERH ALTERRH PURCELLGeert Leroux-Roels

A1 Journal Article in HEPATOLOGY

2007

Serum levels of anti-NS4a and anti-NS5a predict treatment response of patients with chronic hepatitis C

Isabelle DesombereHans Van VlierbergheOla WeilandCatharina HultgrenMatti SallbergJuan QuirogaVicente CarrenoGeert Leroux-Roels

A1 Journal Article in JOURNAL OF MEDICAL VIROLOGY

2006

Partial delipidation improves the T-cell antigenicity of hepatitis B virus surface antigen

Isabelle DesombereAnnick WillemsYvonne GijbelsGeert Leroux-Roels

A1 Journal Article in JOURNAL OF VIROLOGY

2005

Comparison of qualitative (COBAS AMPLICOR HCV 2.0 versus VERSANT HCV RNA) and quantitative (COBAS AMPLICOR HCV monitor 2.0 versus VERSANT HCV RNA 3.0) assays for hepatitis c virus (HCV) RNA detection and quantification: impact on diagnosis and treatment of HCV infections

Isabelle DesombereHans Van VlierbergheSibyl CouventFilip ClinckspoorGeert Leroux-Roels

A1 Journal Article in JOURNAL OF CLINICAL MICROBIOLOGY

Immunogenicity and tolerability of intradermal administration of an HCV E1-based vaccine candidate in healthy volunteers and patients with resolved or ongoing chronic HCV infection

Geert Leroux-RoelsArsene-Helene BatensIsabelle DesombereBart Van den SteenChristine Vander SticheleGeert MaertensFrank Hulstaert

A1 Journal Article in HUMAN VACCINES

Non-responsiveness to hepatitis B surface antigen vaccines is not caused by defective antigen presentation or a lack of B7 co-stimulation

Isabelle DesombereT CAOYvonne GijbelsGeert Leroux-Roels

A1 Journal Article in CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The duration of in vitro stimulation with recall antigens determines the subset distribution of interferon-gamma-producing lymphoid cells: A kinetic analysis using the Interferon-gamma Secretion Assay (TM)

Isabelle DesombereFrédéric ClementHanne RigoleGeert Leroux-Roels

A1 Journal Article in JOURNAL OF IMMUNOLOGICAL METHODS

2004

A candidate vaccine based on the hepatitis C E1 protein: tolerability and immunogenicity in healthy volunteers

Geert Leroux-RoelsE DEPLAF HULSTAERTL TOBBACKS DINCQJ DESMETIsabelle DesombereG MAERTENS

A1 Journal Article in VACCINE

Comparison of two qualitative and two quantitative assays for HCV RNA detection and quantification: impact on diagnosis and treatment of HCV infections

Isabelle DesombereHans Van VlierbergheSibyl CouventFilip ClinckspoorGeert Leroux-Roels

Evidence for a relation between the viral load and genotype and hepatitis C virus-specific T cell responses

C HULTGRENIsabelle DesombereGeert Leroux-RoelsJA QUIROGAV CARRENB NILSSONO WEILANDM SALLBERG

A1 Journal Article in JOURNAL OF HEPATOLOGY

The interferon gamma secretion assay: a reliable tool to study interferon gamma production at the single cell level

Isabelle DesomberePhilip MeulemanHanne RigoleAnnick WillemsJ IRSCHGeert Leroux-Roels

A1 Journal Article in JOURNAL OF IMMUNOLOGICAL METHODS

2003

Humoral and cellular immune responses to subepidermal E1-based therapeutic vaccination in healthy volunteers and patients with past or ongoing HCV infections

Geert Leroux-RoelsAH BATENSIsabelle DesombereB VAN DEN STEENCV STICHELEE D'HONDTG MAERTENSF HULSTAERT

2002

Characterization of HLA DR13-restricted CD4(+) T cell epitopes of hepatitis B core antigen associated with self-limited, acute hepatitis B.

Tinghua CaoIsabelle DesomberePeter VanlandschootM SALLBERGGeert Leroux-Roels

A1 Journal Article in JOURNAL OF GENERAL VIROLOGY

Evolution of hepatitis C virus-specific T cell responses and cytokine production in chronic hepatitis C patients treated with high doses of interferon-alpha.

CA ESQUIVELA ELEWAUTJan PhilippéAE ELEWAUTIsabelle DesombereG MAERTENSGeert Leroux-Roels

A1 Journal Article in REVISTA DE INVESTIGACION CLINICA

Immune response of HLA DQ2 positive subjects, vaccinated with HBsAg/ASO4, a hepatitis B vaccine with a novel adjuvant.

Isabelle DesombereM VAN DER WIELENP VAN DAMMEM STOFFELN DE CLERCQC GOILAVGeert Leroux-Roels

A1 Journal Article in VACCINE

The immunogenicity and reactogenicity profile of a candidate hepatitis B vaccine in an adult vaccine non-responder population.

P JACQUESG MOENSIsabelle DesombereJ DEWIJNGAERTGeert Leroux-RoelsM WETTENDORFFS THOELEN

A1 Journal Article in VACCINE

2001

A candidate therapeutic vaccine for chronic hepatitis C infection based on envelope 1 protein: Tolerability and immunogenicity in healthy adult volunteers

Geert Leroux-RoelsE DEPLAF HULSTAERTJ DE SMEDTIsabelle DesombereG MAERTENS

Hepatitis B virus core antigen binds and activates naive human B cells in vivo: Studies with a human PBL-NOD/SCID mouse model.

Tinghua CaoU LAZDINAIsabelle DesomberePeter VanlandschootDR MILICHM SALLBERGGeert Leroux-Roels

A1 Journal Article in JOURNAL OF VIROLOGY

In vivo inhibition of anti-HBcIgG production by HBcAg-specific CD4+Th1-type T cell clones in a hu-PBL-NOD/SCID mice model

TH CAOPhilip MeulemanIsabelle DesombereM SALLBERGGeert Leroux-Roels

In vivo inhibition of anti-hepatitis B virus core antigen (HBcAg) immunoglobulin G production by HBcAg-specific CD4(+) Th1-type T-cell clones in a hu-PBL-NOD/SCID mouse model.

Tinghua CaoPhilip MeulemanIsabelle DesombereM SALLBERGGeert Leroux-Roels

A1 Journal Article in JOURNAL OF VIROLOGY

Long-term persistence of antibodies induced by vaccination and safety follow-up, with the first combined vaccine against hepatitis A and B in children and adults

P Van DammeGeert Leroux-RoelsB LawF Diaz-MitomaIsabelle DesombereF CollardN TornieporthKoen Van Herck

A1 Journal Article in JOURNAL OF MEDICAL VIROLOGY

Prevention of hepatitis B infections: Vaccination and its limitations

Geert Leroux-RoelsT CAOA DE KNIBBERPhilip MeulemanA ROOBROUCKA FARHOUDIPeter VanlandschootIsabelle Desombere

A1 Journal Article in ACTA CLINICA BELGICA

2000

A hepatitis B vaccine formulated with a novel adjuvant system.

F AMBROSCHG WIEDERMANNM KUNDIGeert Leroux-RoelsIsabelle DesombereN GARCONC THIRIARTM SLAOUIS THOELEN

A1 Journal Article in VACCINE

Characterization of the T cell recognition of hepatitis B surface antigen (HBsAg) by good and poor responders to hepatitis B vaccines

Isabelle DesombereYvonne GijbelsAndréa VerwulgenGeert Leroux-Roels

A1 Journal Article in CLINICAL AND EXPERIMENTAL IMMUNOLOGY

1998

Human immune response to envelope proteins of the hepatitis B virus.

Isabelle DesombereGeert Leroux-Roels

Partial delipidation improves the T cell immunogenicity of hepatitis B surface antigen

Isabelle DesombereGeert Leroux-RoelsM WETTENDORFAnnick WillemsYvonne GijbelsAndréa Verwulgen

Response to hepatitis B vaccine: Multiple HLA genes are involved

Isabelle DesombereAnnick WillemsGeert Leroux-Roels

Response to hepatitis B vaccine: multiple HLA genes are involved

Isabelle DesombereAnnick WillemsGeert Leroux-Roels

A1 Journal Article in TISSUE ANTIGENS

Safety and immunogenicity of a hepatitis B vaccine formulated with a novel adjuvant system.

S THOELENP VAN DAMMEC MATHEIGeert Leroux-RoelsIsabelle DesombereA SAFARYP VANDEPAPELIEREM SLAOUIA MEHEUS

A1 Journal Article in VACCINE

1997

Cytotoxic T lymphocytes in HBV and HCV infections: beneficial or harmful ?

Geert Leroux-RoelsIsabelle DesombereS DEPRAETEREC TINGHUAE VAN KERSCHAVER

A2 Journal Article in Central-European Journal of Immunology

Hepatitis B vaccine containing surface antigen and selected preS1 and preS2 sequences .1. Safety and immunogenicity in young, healthy adults.

Geert Leroux-RoelsIsabelle DesombereG DETOLLENAEREMA PETITP DESMONSP HAUSERA DELEMD DEGRAVEA SAFARY

A1 Journal Article in VACCINE

Hepatitis B vaccine containing surface antigen and selected preS1 and preS2 sequences .2. Immunogenicity in poor responders to hepatitis B vaccines.

Geert Leroux-RoelsIsabelle DesombereL COBBAUTMA PETITP DESMONSP HAUSERA DELEMD DEGRAVEA SAFARY

A1 Journal Article in VACCINE

1996

Influence of combinations of HLA class II genes on the human immune response to hepatitis B vaccine

Isabelle DesombereGeert Leroux-Roels

Lymphoproliferative responses to hepatitis C virus core, E1, E2, and NS3 in patients with chronic hepatitis C infection treated with interferon alfa.

Geert Leroux-RoelsCA ESQUIVELR DELEYSL STUYVERAndré ElewautJan PhilippéIsabelle DesombereJoseph ParadijsG MAERTENS

A1 Journal Article in HEPATOLOGY

Safety and immunogenicity of a combined hepatitis A and hepatitis B vaccine in young healthy adults.

Geert Leroux-RoelsE MOREAUIsabelle DesombereA SAFARY

A1 Journal Article in SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

1995

ANALYSIS OF THE ANTI-HBS RESPONSE OF ELDERLY SUBJECTS TO HBV VACCINE

Isabelle DesombereLuc CobbautM SLAOUIGeert Leroux-Roels

Cytokines in vaccine research

Geert Leroux-RoelsIsabelle DesombereJ PARADIJSJ VINGERHOETSJan Philippé

A4 Journal Article in Cytokine News - Medgenix Diagnostics

NONRESPONDERS TO HEPATITIS-B VACCINE CAN PRESENT ENVELOPE PARTICLES TO T-LYMPHOCYTES

Isabelle DesombereP HAUSERR ROSSAUJ PARADIJSGeert Leroux-Roels

A1 Journal Article in JOURNAL OF IMMUNOLOGY

1994

T-CELL EPITOPES OF HEPATITIS-B VIRUS ENVELOPE GLYCOPROTEINS (HBV-ENV) RECOGNIZED BY GOOD RESPONDERS TO HBV-ENV VACCINES

Geert Leroux-RoelsIsabelle DesombereP VOETJ PETREP HAUSER

Waarom wordt een hepatitis B virus infectie soms chronisch ?

Geert Leroux-RoelsIsabelle DesombereJ PARADIJSAndré Elewaut

A4 Journal Article in Roche in Virology

1993

HAPTOGLOBIN POLYMORPHISM AND THE IMMUNE-RESPONSE AFTER HEPATITIS-B VACCINATION.

H LOUAGIEJoris DelangheIsabelle DesombereMarc De BuyzereP HAUSERGeert Leroux-Roels

A1 Journal Article in VACCINE

Immunogenicity of a new hepatitis B vaccine containing preS1 and preS2 epitopes

Geert Leroux-RoelsIsabelle DesombereP HAUSERP DEGRAVEJ PETREP VANDEPAPELIEREA SAFARY

NONRESPONDERS TO HEPATITIS-B VACCINE CAN PRESENT HBSAG TO T-LYMPHOCYTES

Geert Leroux-RoelsIsabelle DesombereP VOETP HAUSER

PLASMODIUM-BERGHEI - THE USE OF DISCONTINUOUS UROGRAFIN DENSITY GRADIENTS FOR THE SEPARATION OF EXOERYTHROCYTIC MALARIA PARASITES

G FRANCOISIsabelle DesombereM WERY

A1 Journal Article in ANNALES DE PARASITOLOGIE HUMAINE ET COMPAREE

Waarom wordt een hepatitis B virus infectie soms chronisch ?

Geert Leroux-RoelsIsabelle DesombereJ PARADYSAndré Elewaut

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

1992

Non-responsiveness to hepatitis B surface antigen (HBsAg) in vaccine recipients

Geert Leroux-RoelsIsabelle DesombereEric Van HeckeP VOETP HAUSER

1991

PLASMODIUM-BERGHEI - SUSCEPTIBILITY AND GROWTH-CHARACTERISTICS OF HEPATOMA-CELLS AS HOSTS FOR MALARIA SCHIZONTS

G FRANCOISIsabelle DesombereM WERY

A1 Journal Article in ANNALES DE PARASITOLOGIE HUMAINE ET COMPAREE

Cytotoxic T lymphocytes in HBV and HCV infections: beneficial or harmful ? Central-EurJ Immunol 1997,22: 155-157.

Geert Leroux-RoelsIsabelle DesombereStany DepraetereC TINGHUA

Immunogenicity of a new hepatitis B vaccine containing preSl and preS2 epitopes. Proc. of the 8th Triennial Congress: 1993 International Sympo sium on Viral Hepatitis and Liver Disease. Tokyo, May 10-14, 1993, p. 164.

Geert Leroux-RoelsIsabelle DesombereP HAUSERPatrick DegraveJ PETREP VANDEPAPELIEREA SAFARY

Non-responsiveness to hepatitis B surface antigen (HBsAg) in vaccine recipients. Falk Symposium nr. 70, Immunology and Liver, oct. 18-20, 1992.

Geert Leroux-RoelsIsabelle DesombereEric Van HeckeP VOETP HAUSER