Research Explorer

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Researcher

Isabelle Carpentier

Awards & Distinctions

30 Results

2018

The E3 ubiquitin ligases HOIP and cIAP1 are recruited to the TNFR2 signaling complex and mediate TNFR2-induced canonical NF-κB signaling

Alice BorghiMira HaegmanRoman FischerIsabelle CarpentierMathieu BertrandClaude LibertInna AfoninaRudi Beyaert

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

2016

MALT1 cleaves the E3 ubiquitin ligase HOIL-1 in activated T cells, generating a dominant negative inhibitor of LUBAC-induced NF-κB signaling

Lynn EltonIsabelle CarpentierJens StaalYasmine DriegeMira HaegmanRudi Beyaert

A1 Journal Article in FEBS JOURNAL

New insight into the ubiquitin-mediated regulation of TNFR2 signaling

Alice BorghiRudi BeyaertIsabelle Carpentier

2015

MALT1-a universal soldier: multiple strategies to ensure NF-κB activation and target gene expression

Inna AfoninaLynn EltonIsabelle CarpentierRudi Beyaert

A1 Journal Article in FEBS JOURNAL

The multifaceted role of the E3 ubiquitin ligase HOIL-1: beyond linear ubiquitination

Lynn EltonIsabelle CarpentierKelly VerhelstJens StaalRudi Beyaert

A1 Journal Article in IMMUNOLOGICAL REVIEWS

XEDAR activates the non-canonical NF-κB pathway

Kelly VerhelstSandra GardamAlice BorghiMarja KreikeIsabelle CarpentierRudi Beyaert

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

2014

The biology of A20-binding inhibitors of NF-κB activation (ABINs)

Lynn VerstrepenIsabelle CarpentierRudi Beyaert

A1 Journal Article in Advances in Experimental Medicine and Biology

2013

IκB kinase ε (IKKε): a therapeutic target in inflammation and cancer

Kelly VerhelstLynn VerstrepenIsabelle CarpentierRudi Beyaert

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

2012

A20 (Tnfaip3) deficiency in myeloid cells protects against influenza A virus infection

Jonathan MaelfaitKenny RoosePieter BogaertMozes SzeXavier SaelensManolis PasparakisIsabelle CarpentierGeert van LooRudi Beyaert

A1 Journal Article in PLOS PATHOGENS

A20 inhibits LUBAC-mediated NF-κB activation by binding linear polyubiquitin chains via its zinc finger 7

Kelly VerhelstIsabelle CarpentierMarja KreikeLaura MeloniLynn VerstrepenTobias KenscheIvan DikicRudi Beyaert

A1 Journal Article in EMBO JOURNAL

Structure and function of the type III secretion system of Pseudomonas aeruginosa

Marlies GalleIsabelle CarpentierRudi Beyaert

A1 Journal Article in CURRENT PROTEIN & PEPTIDE SCIENCE

2011

Linear ubiquitination in NF-κB signaling and inflammation: what we do understand and what we do not

Kelly VerhelstLynn VerstrepenIsabelle CarpentierRudi Beyaert

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Regulation of TNF-induced NF-κB activation by different cytoplasmic ubiquitination events

Kelly VerhelstIsabelle CarpentierRudi Beyaert

A1 Journal Article in CYTOKINE & GROWTH FACTOR REVIEWS

TAX1BP1, a ubiquitin-binding adaptor protein in innate immunity and beyond

Lynn VerstrepenKelly VerhelstIsabelle CarpentierRudi Beyaert

A1 Journal Article in TRENDS IN BIOCHEMICAL SCIENCES

2010

Expression, biological activities and mechanisms of action of A20 (TNFAIP3)

Lynn VerstrepenKelly VerhelstGeert van LooIsabelle CarpentierSteven C LeyRudi Beyaert

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

2009

A20: Central Gatekeeper in Inflammation and Immunity

Beatrice CoornaertIsabelle CarpentierRudi Beyaert

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

ABINs: A20 binding inhibitors of NF-kappa B and apoptosis signaling

Lynn VerstrepenIsabelle CarpentierKelly VerhelstRudi Beyaert

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Cellular expression of A20 and ABIN-3 in response to Toll-like receptor-4 stimulation

Kelly VerhelstLynn VerstrepenBeatrice CoornaertIsabelle CarpentierRudi Beyaert

Bookchapter in Toll-like receptors : methods and protocols

2008

Are the IKKs and IKK-related kinases TBK1 and IKK-epsilon similarly activated?

TL CHAUR GIOIAJS GATOTF PATRASCUIsabelle CarpentierJP CHAPELLEL O'NEILRudi BeyaertJ PIETTEA CHARIOT

A1 Journal Article in TRENDS IN BIOCHEMICAL SCIENCES

Expression of the NF-kappa B inhibitor ABIN-3 in response to TNF and toll-like receptor 4 stimulation is itself regulated by NF-kappa B

Lynn VerstrepenM ADIB-CONQUYMarja KreikeIsabelle CarpentierC ADRIEJM CAVAILLONRudi Beyaert

A1 Journal Article in JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Smurf2 is a TRAF2 binding protein that triggers TNF-R2 ubiquitination and TNF-R2-induced JNK activation

Isabelle CarpentierBeatrice CoornaertRudi Beyaert

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ubiquitin binding mediates the NF-kappa B inhibitory potential of ABIN proteins

S WAGNERIsabelle CarpentierV ROGOVMarja KreikeF IKEDAF LOHRCJ WUJD ASHWELLV DOTSCHI DIKIC et al.

A1 Journal Article in ONCOGENE

2007

LIND/ABIN-3 is a novel lipopolysaccharide-inducible inhibitor of NF-kappa B activation

Andy WullaertLynn VerstrepenSofie Van HuffelM Adib-ConquySigrid CornelisMarja KreikeMira HaegmanKarim El BakkouriMatthew SandersKelly Verhelst et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2004

Enhanced osteoclast development in collagen-induced arthritis in interferon-gamma receptor knock-out mice as related to increased splenic CD11b(+) myelopoiesis

B DE KLERCKIsabelle CarpentierRJ LORIESY HABRAKENJ PIETTEG CARMELIETRudi BeyaertA BILLIAUP MATTHYS

A1 Journal Article in ARTHRITIS RESEARCH & THERAPY

Function and regulation of tumor necrosis factor receptor type 2

Isabelle CarpentierBeatrice CoornaertRudi Beyaert

A1 Journal Article in CURRENT MEDICINAL CHEMISTRY

2003

Molecular and functional characterisation of the tumor necrosis factor associated proteins TRAF1 and TRAF2

Isabelle CarpentierRudi BeyaertFrans Van Roy

NF-κB activation by tumor necrosis factor and interleukin-1

Isabelle CarpentierSophie JanssensKaren HeyninckRudi Beyaert

Bookchapter in Nuclear factor κB : regulation and role in disease

2001

Lithium sensitizes tumor cells in an NF-kappa B-independent way to caspase activation and apoptosis induced by tumor necrosis factor (TNF) - Evidence for a role of the TNF receptor-associated death domain protein.

Peter SchotteGeert van LooIsabelle CarpentierPeter VandenabeeleRudi Beyaert

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

1999

TRAF1 is a TNF inducible regulator of NF-kappa B activation.

Isabelle CarpentierRudi Beyaert

A1 Journal Article in FEBS LETTERS

1998

TRAF2 plays a dual role in NF-kappa B-dependent gene activation by mediating the TNF-induced activation of p38 MAPK and I kappa B kinase pathways.

Isabelle CarpentierWim DeclercqNL MALININD WALLACHWalter FiersRudi Beyaert

A1 Journal Article in FEBS LETTERS