Research Explorer

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Researcher

Irina Okkelman

Awards & Distinctions

23 Results

2025

Fluorescence Lifetime Imaging Microscopy (FLIM) visualizes internalization and biological impact of nanoplastics in live intestinal organoids

Irina OkkelmanHang ZhouSergey M. BorisovAngela DebruyneAustin E.Y.T. LefebvreMarcello Leomil ZoccolerLinglong ChenBert DevriendtRuslan Dmitriev

Front cover : optoelectronic properties and fluorescence lifetime imaging application of donor‐acceptor dyads derived from 2,6‐dicarboxyBODIPY (Chem. Eur. J. 10/2025)

Aimee SheehanIrina OkkelmanGeoffrey GroslambertChristophe BucherRuslan DmitrievMikhail A. Filatov

Lack of biochemical signalling in GelMA leads to polarity reversion in intestinal organoids independent from mechanoreciprocity

Lenie VanhoveThomas Van GansbekeBert DevriendtRuben Van der MeerenRuslan DmitrievIrina Okkelman

A1 Journal Article in JOURNAL OF TISSUE ENGINEERING

Optoelectronic properties and fluorescence lifetime imaging application of donor‐acceptor dyads derived from 2,6‐dicarboxyBODIPY

Aimee SheehanIrina OkkelmanGeoffrey GroslambertChristophe BucherRuslan DmitrievMikhail A. Filatov

A1 Journal Article in CHEMISTRY-A EUROPEAN JOURNAL

Poly(2-alkyl-2-oxazoline) hydrogels as synthetic matrices for multicellular spheroid and intestinal organoid cultures

Robin VanhoeijenIrina OkkelmanNette RogierTomáš SedlačíkDaniel StöbenerBert DevriendtRuslan DmitrievRichard Hoogenboom

A1 Journal Article in BIOMACROMOLECULES

2024

In Vivo fluorescence lifetime imaging : added value for tumor imaging and importance of fluorophore selection

Simone JanssenThomas Van den DriesMarcus StroetSevada SahakianThomas LapauwIrina OkkelmanRuslan DmitrievMaarten KuijkHans IngelbertsSophie Hernot

Live microscopy of multicellular spheroids with the multimodal near-infrared nanoparticles reveals differences in oxygenation gradients

Angela DebruyneIrina OkkelmanNina HeymansCláudio PinheiroAn HendrixMax NobisSergey M. BorisovRuslan Dmitriev

A1 Journal Article in ACS NANO

Navigating the fate of intestinal epithelial cells in the world of nanoplastic pollution via Fluorescence Lifetime Imaging Microscopy (FLIM)

Irina OkkelmanBert DevriendtRuslan Dmitriev

Oxygenation gradients in multicellular spheroids : are they always as expected?

Angela DebruyneIrina OkkelmanSergey M. BorisovRuslan Dmitriev

Production and multi-parameter live cell fluorescence lifetime imaging microscopy (FLIM) of multicellular spheroids

Angela DebruyneGabriele FerrariHang ZhouNore Van LoonNina HeymansIrina OkkelmanRuslan Dmitriev

A1 Journal Article in JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

2023

Balance between the cell viability and death in 3D

Angela DebruyneIrina OkkelmanRuslan Dmitriev

A1 Journal Article in SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Fluorescence intensity and Fluorescence Lifetime Imaging Microscopies (FLIM) of cell differentiation in the small intestinal organoids using cholera toxin

Irina OkkelmanRuslan Dmitriev

Bookchapter in Intestinal differentiated cells : methods and protocols

Live microscopy of multicellular spheroids with the multi-modal near-infrared nanoparticles reveals differences in oxygenation gradients

Angela DebruyneIrina OkkelmanNina HeymansMax NobisSergey M. BorisovRuslan Dmitriev

Probing tumor spheroid hypoxia using red/near-infrared ratiometric O2-sensitive nanoparticles

Angela DebruyneIrina OkkelmanSergey BorisovRuslan Dmitriev

Role of preconditioning with oxygen and glucose deprivation in promoting differentiation of dental pulp stem cells in 3D culture

Irina OkkelmanWinter VandenbergheRuslan Dmitriev

TIE2 receptor localization in glomerular podocytes using super resolution microscopy and fluorescence lifetime imaging microscopy

Iulia-Aneta DénesIrina OkkelmanHerlinde De KeersmaeckerRuslan DmitrievWard De Spiegelaere

2022

Affordable oxygen microscopy-assisted biofabrication of multicellular spheroids

Irina OkkelmanChris VercruysseAlina V. KondrashinaSergey M. BorisovRuslan Dmitriev

A1 Journal Article in JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

2020

Extruded phosphorescence based oxygen sensors for large-scale packaging applications

Caroline KellyDilidaer YusufuIrina OkkelmanSwagata BanerjeeJoe P. KerryAndrew MillsDmitri B. Papkovsky

A1 Journal Article in SENSORS AND ACTUATORS B-CHEMICAL

2018

Cellulose-based scaffolds for fluorescence lifetime imaging-assisted tissue engineering

Neil O'DonnellIrina OkkelmanPeter TimashevTatyana I. GromovykhDmitri B. PapkovskyRuslan Dmitriev

A1 Journal Article in ACTA BIOMATERIALIA

Nanoparticle-based fluoroionophore for analysis of potassium ion dynamics in 3D tissue models and in vivo

Bernhard J. MuellerAlexander V. ZhdanovSergey M. BorisovTara FoleyIrina OkkelmanVassiliy TsytsarevQinggong TangReha S. ErzurumluYu ChenHaijiang Zhang et al.

A1 Journal Article in ADVANCED FUNCTIONAL MATERIALS

2017

Live cell imaging of mouse intestinal organoids reveals heterogeneity in their oxygenation

Irina OkkelmanTara FoleyDmitri B. PapkovskyRuslan Dmitriev

A1 Journal Article in BIOMATERIALS

2015

A novel effect of DMOG on cell metabolism : direct inhibition of mitochondrial function precedes HIF target gene expression

Alexander V. ZhdanovIrina OkkelmanFergus W. J. CollinsSilvia MelgarDmitri B. Papkovsky

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

P4-ATPase Atp8b1/FIC1 : structural features and physiological functions in health and disease

T. V. KorneenkoN. B. PestovIrina OkkelmanN. N. ModyanovM. I. Shakhparonov

A1 Journal Article in RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY