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Researcher
Irina Okkelman
Profile
Projects
Publications & Research Data
Activities
Awards & Distinctions
Patents
26
Results
2025
Cell-specific mRNA delivery via nanobody-functionalized lipid nanoparticles
Linglong Chen
Hans Van Der Weken
Olivier Zwaenepoel
Irina Okkelman
Justine Aelvoet
Emma Van Denberghe
Jan Gettemans
Ruslan Dmitriev
Bruno De Geest
Eric Cox
et al.
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2025
Fluorescence Lifetime Imaging Microscopy (FLIM) visualizes internalization and biological impact of nanoplastics in live intestinal organoids
Irina Okkelman
Hang Zhou
Sergey M. Borisov
Angela Debruyne
Austin E.Y.T. Lefebvre
Marcello Leomil Zoccoler
Linglong Chen
Bert Devriendt
Ruslan Dmitriev
Preprint
2025
Front cover : optoelectronic properties and fluorescence lifetime imaging application of donor‐acceptor dyads derived from 2,6‐dicarboxyBODIPY (Chem. Eur. J. 10/2025)
Aimee Sheehan
Irina Okkelman
Geoffrey Groslambert
Christophe Bucher
Ruslan Dmitriev
Mikhail A. Filatov
Other
2025
Lack of biochemical signalling in GelMA leads to polarity reversion in intestinal organoids independent from mechanoreciprocity
Lenie Vanhove
Thomas Van Gansbeke
Bert Devriendt
Ruben Van der Meeren
Ruslan Dmitriev
Irina Okkelman
A1
Journal Article
in
JOURNAL OF TISSUE ENGINEERING
2025
Optoelectronic properties and fluorescence lifetime imaging application of donor‐acceptor dyads derived from 2,6‐dicarboxyBODIPY
Aimee Sheehan
Irina Okkelman
Geoffrey Groslambert
Christophe Bucher
Ruslan Dmitriev
Mikhail A. Filatov
A1
Journal Article
in
CHEMISTRY-A EUROPEAN JOURNAL
2025
Poly(2-alkyl-2-oxazoline) hydrogels as synthetic matrices for multicellular spheroid and intestinal organoid cultures
Robin Vanhoeijen
Irina Okkelman
Nette Rogier
Tomáš Sedlačík
Daniel Stöbener
Bert Devriendt
Ruslan Dmitriev
Richard Hoogenboom
A1
Journal Article
in
BIOMACROMOLECULES
2025
Visualizing the internalization and biological impact of nanoplastics in live intestinal organoids by Fluorescence Lifetime Imaging Microscopy (FLIM)
Irina Okkelman
Hang Zhou
Sergey Borisov
Angela Debruyne
Austin Lefebvre
Marcelo Leomil Zoccoler
Linglong Chen
Bert Devriendt
Ruslan Dmitriev
A1
Journal Article
in
LIGHT-SCIENCE & APPLICATIONS
2025
2024
In Vivo fluorescence lifetime imaging : added value for tumor imaging and importance of fluorophore selection
Simone Janssen
Thomas Van den Dries
Marcus Stroet
Sevada Sahakian
Thomas Lapauw
Irina Okkelman
Ruslan Dmitriev
Maarten Kuijk
Hans Ingelberts
Sophie Hernot
C3
Conference
2024
Live microscopy of multicellular spheroids with the multimodal near-infrared nanoparticles reveals differences in oxygenation gradients
Angela Debruyne
Irina Okkelman
Nina Heymans
Cláudio Pinheiro
An Hendrix
Max Nobis
Sergey M. Borisov
Ruslan Dmitriev
A1
Journal Article
in
ACS NANO
2024
Navigating the fate of intestinal epithelial cells in the world of nanoplastic pollution via Fluorescence Lifetime Imaging Microscopy (FLIM)
Irina Okkelman
Bert Devriendt
Ruslan Dmitriev
C3
Conference
2024
Oxygenation gradients in multicellular spheroids : are they always as expected?
Angela Debruyne
Irina Okkelman
Sergey M. Borisov
Ruslan Dmitriev
C3
Conference
2024
Production and multi-parameter live cell fluorescence lifetime imaging microscopy (FLIM) of multicellular spheroids
Angela Debruyne
Gabriele Ferrari
Hang Zhou
Nore Van Loon
Nina Heymans
Irina Okkelman
Ruslan Dmitriev
A1
Journal Article
in
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
2024
2023
Balance between the cell viability and death in 3D
Angela Debruyne
Irina Okkelman
Ruslan Dmitriev
A1
Journal Article
in
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
2023
Fluorescence intensity and Fluorescence Lifetime Imaging Microscopies (FLIM) of cell differentiation in the small intestinal organoids using cholera toxin
Irina Okkelman
Ruslan Dmitriev
Bookchapter
in
Intestinal differentiated cells : methods and protocols
2023
Live microscopy of multicellular spheroids with the multi-modal near-infrared nanoparticles reveals differences in oxygenation gradients
Angela Debruyne
Irina Okkelman
Nina Heymans
Max Nobis
Sergey M. Borisov
Ruslan Dmitriev
Preprint
2023
Probing tumor spheroid hypoxia using red/near-infrared ratiometric O2-sensitive nanoparticles
Angela Debruyne
Irina Okkelman
Sergey Borisov
Ruslan Dmitriev
C3
Conference
2023
Role of preconditioning with oxygen and glucose deprivation in promoting differentiation of dental pulp stem cells in 3D culture
Irina Okkelman
Winter Vandenberghe
Ruslan Dmitriev
C3
Conference
2023
TIE2 receptor localization in glomerular podocytes using super resolution microscopy and fluorescence lifetime imaging microscopy
Iulia-Aneta Dénes
Irina Okkelman
Herlinde De Keersmaecker
Ruslan Dmitriev
Ward De Spiegelaere
C3
Conference
2023
2022
Affordable oxygen microscopy-assisted biofabrication of multicellular spheroids
Irina Okkelman
Chris Vercruysse
Alina V. Kondrashina
Sergey M. Borisov
Ruslan Dmitriev
A1
Journal Article
in
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
2022
2020
Extruded phosphorescence based oxygen sensors for large-scale packaging applications
Caroline Kelly
Dilidaer Yusufu
Irina Okkelman
Swagata Banerjee
Joe P. Kerry
Andrew Mills
Dmitri B. Papkovsky
A1
Journal Article
in
SENSORS AND ACTUATORS B-CHEMICAL
2020
2018
Cellulose-based scaffolds for fluorescence lifetime imaging-assisted tissue engineering
Neil O'Donnell
Irina Okkelman
Peter Timashev
Tatyana I. Gromovykh
Dmitri B. Papkovsky
Ruslan Dmitriev
A1
Journal Article
in
ACTA BIOMATERIALIA
2018
Nanoparticle-based fluoroionophore for analysis of potassium ion dynamics in 3D tissue models and in vivo
Bernhard J. Mueller
Alexander V. Zhdanov
Sergey M. Borisov
Tara Foley
Irina Okkelman
Vassiliy Tsytsarev
Qinggong Tang
Reha S. Erzurumlu
Yu Chen
Haijiang Zhang
et al.
A1
Journal Article
in
ADVANCED FUNCTIONAL MATERIALS
2018
2017
Live cell imaging of mouse intestinal organoids reveals heterogeneity in their oxygenation
Irina Okkelman
Tara Foley
Dmitri B. Papkovsky
Ruslan Dmitriev
A1
Journal Article
in
BIOMATERIALS
2017
2015
A novel effect of DMOG on cell metabolism : direct inhibition of mitochondrial function precedes HIF target gene expression
Alexander V. Zhdanov
Irina Okkelman
Fergus W. J. Collins
Silvia Melgar
Dmitri B. Papkovsky
A1
Journal Article
in
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
2015
P4-ATPase Atp8b1/FIC1 : structural features and physiological functions in health and disease
T. V. Korneenko
N. B. Pestov
Irina Okkelman
N. N. Modyanov
M. I. Shakhparonov
A1
Journal Article
in
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY
2015
2011
Control of lysyl oxidase activity through site-specific deuteration of lysine
Nikolay B. Pestov
Irina Okkelman
Vadim V. Shmanai
Alaksiej L. Hurski
Amato J. Giaccia
Mikhail S. Shchepinov
A1
Journal Article
in
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
2011