Research Explorer

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Researcher

Inna Afonina

Awards & Distinctions

34 Results

2024

CARD14 signalosome formation is associated with its endosomal relocation and mTORC1-induced keratinocyte proliferation

Paul A O'SullivanAigerim AidarovaInna AfoninaJoan ManilsTeresa L M ThurstonRachel InstrellMichael HowellStefan BoeingSashini RanawanaMelanie Herpels et al.

A1 Journal Article in BIOCHEMICAL JOURNAL

Polo-like kinase 1 (PLK1) is a novel CARD14-binding protein in keratinocytes

Styliani IliakiMarja KreikeNatalia Ferreras MorenoFemke De MeyerAigerim AidarovaHarald BraunClaude LibertInna AfoninaRudi Beyaert

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

2023

A20 is a master switch of IL-33 signalling in macrophages and determines IL-33-induced lung immunity

Aurora Holgado MuñozZhuangzhuang LiuAigerim AidarovaChristina MüllerMira HaegmanYasmine DriegeMarja KreikeCharlotte ScottInna AfoninaRudi Beyaert

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-5-producing CD4+ T cells and eosinophils cooperate to enhance response to immune checkpoint blockade in breast cancer

Olga S. BlombergLorenzo SpagnuoloHannah GarnerLeonie VoorwerkOlga I. IsaevaEwald van DykNoor BakkerMyriam ChalabiChris KlaverMaxime Duijst et al.

A1 Journal Article in CANCER CELL

Novel role for linear ubiquitination in regulating NFAT1 stability

Femke De MeyerInna Afonina

Editorial material

2022

CARD14 signalling ensures cell survival and cancer associated gene expression in prostate cancer cells

Domien VannesteJens StaalMira HaegmanYasmine DriegeMarieke CarelsElien Van NuffelPieter De BleserYvan SaeysRudi BeyaertInna Afonina

A1 Journal Article in BIOMEDICINES

Editorial: Post-translational modifications of extracellular signaling molecules and antigens in immune and inflammatory responses

Inna AfoninaLoredana FrascaGaby Palmer

Editorial material

Identification and functional characterization of CARD14 protein-protein interactions

Styliani IliakiRudi BeyaertInna Afonina

Infection and immunity : 'There Are Things Out There You (Don't) Need To Know About'

Inna AfoninaEik Hoffmann

Editorial material

Targeting and regulation of interleukin-33 signalling in lung inflammation

Aurora Holgado MuñozRudi BeyaertInna Afonina

2021

Defining the combinatorial space of PKC::CARD-CC signal transduction nodes

Jens StaalYasmine DriegeMira HaegmanMarja KreikeStyliani IliakiDomien VannesteMarie LorkInna AfoninaHarald BraunRudi Beyaert

A1 Journal Article in FEBS JOURNAL

IL-33trap-mediated IL-33 neutralization does not exacerbate choroidal neovascularization, but fails to protect against retinal degeneration in a dry age-related macular degeneration model

Inge Van HoveTine Van BergenIsabelle EtienneAurora Holgado MuñozInna AfoninaRudi BeyaertJean HM. FeyenTjing-Tjing Hu

A1 Journal Article in EXPERIMENTAL EYE RESEARCH

Immune responses and therapeutic options in psoriasis

Inna AfoninaElien Van NuffelRudi Beyaert

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Polo-like kinase 1 (PLK1) signaling in cancer and beyond

Styliani IliakiRudi BeyaertInna Afonina

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

2020

MALT1 targeting suppresses CARD14‐induced psoriatic dermatitis in mice

Elien Van NuffelJens StaalGriet BaudeletMira HaegmanYasmine DriegeTino HochepiedInna AfoninaRudi Beyaert

A1 Journal Article in EMBO REPORTS

Single-chain soluble receptor fusion proteins as versatile cytokine inhibitors

Aurora Holgado MuñozHarald BraunKenneth VerstraeteDomien VannesteNico CallewaertSavvas SavvidesInna AfoninaRudi Beyaert

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

2019

CARD14/MALT1 signaling in skin homeostasis and disease

Elien Van NuffelRudi BeyaertInna Afonina

IL-33trap is a novel IL-33-neutralizing biologic that inhibits allergic airway inflammation

Aurora Holgado MuñozHarald BraunElien Van NuffelSammy DetryMartijn SchuijsKim DeswarteKarl VergoteMira HaegmanGriet BaudeletJurgen Haustraete et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

2018

Dichotomous function of IL-33 in health and disease : from biology to clinical implications

Harald BraunInna AfoninaChristina MuellerRudi Beyaert

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Mepazine inhibits RANK-induced osteoclastogenesis independent of its MALT1 inhibitory function

Laura MeloniLynn VerstrepenMarja KreikeJens StaalYasmine DriegeInna AfoninaRudi Beyaert

A1 Journal Article in MOLECULES

Psoriasis plays a wild CARD

Elien Van NuffelInna AfoninaRudi Beyaert

Editorial material

The E3 ubiquitin ligases HOIP and cIAP1 are recruited to the TNFR2 signaling complex and mediate TNFR2-induced canonical NF-κB signaling

Alice BorghiMira HaegmanRoman FischerIsabelle CarpentierMathieu BertrandClaude LibertInna AfoninaRudi Beyaert

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

2017

CARD14-mediated activation of paracaspase MALT1 in keratinocytes : implications for psoriasis

Elien Van NuffelAnja SchmittInna AfoninaKlaus Schulze-OsthoffRudi BeyaertStephan Hailfinger

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

Limiting inflammation : the negative regulation of NF-κB and the NLRP3 inflammasome

Inna AfoninaZhenyu ZhongMichael KarinRudi Beyaert

A1 Journal Article in NATURE IMMUNOLOGY

2016

Neutrophil-derived proteases escalate inflammation through activation of IL-36 family cytokines

Conor HenryGraeme SullivanDanielle ClancyInna AfoninaDagmar KulmsSeamus Martin

A1 Journal Article in CELL REPORTS

The paracaspase MALT1 mediates CARD14-induced signaling in keratinocytes

Inna AfoninaElien Van NuffelGriet BaudeletYasmine DriegeMarja KreikeJens StaalRudi Beyaert

A1 Journal Article in EMBO REPORTS

Trabid epigenetically drives expression of IL-12 and IL-23

Inna AfoninaRudi Beyaert

Editorial material

2015

MALT1-a universal soldier: multiple strategies to ensure NF-κB activation and target gene expression

Inna AfoninaLynn EltonIsabelle CarpentierRudi Beyaert

A1 Journal Article in FEBS JOURNAL

Proteolytic processing of interleukin-1 family cytokines: variations on a common theme

Inna AfoninaChristina MüllerSeamus J MartinRudi Beyaert

A1 Journal Article in IMMUNITY

2013

Inhibitor of apoptosis proteins (IAPs) and their antagonists regulate spontaneous and tumor necrosis factor (TNF)-induced proinflammatory cytokine and chemokine production

Conor J. KearneyClare SheridanSean P. CullenGraham A. TynanSusan E. LogueInna AfoninaDomagoj VucicEd C. LavelleSeamus J. Martin

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2011

Granzyme B-dependent proteolysis acts as a switch to enhance the proinflammatory activity of IL-1 alpha

Inna AfoninaGraham A. TynanSusan E. LogueSean P. CullenMichael BotsAlexander U. LuethiEmer P. ReevesNoel G. McElvaneyJan P. MedemaEd C. Lavelle et al.

A1 Journal Article in MOLECULAR CELL

2010

Cytotoxic and non-cytotoxic roles of the CTL/NK protease granzyme B

Inna AfoninaSean P. CullenSeamus J. Martin

A1 Journal Article in IMMUNOLOGICAL REVIEWS

2009

Nucleophosmin is cleaved and inactivated by the cytotoxic granule protease granzyme M during natural killer cell-mediated killing

Sean P. CullenInna AfoninaRoberta DonadiniAlexander U. LuethiJan Paul MedemaPhillip I. BirdSeamus J. Martin

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases

Alexander U. LuthiSean P. CullenEdel A. McNeelaPatrick J. DuriezInna AfoninaClare SheridanGabriela BrumattiRebecca C. TaylorKristof KerssePeter Vandenabeele et al.

A1 Journal Article in IMMUNITY