Research Explorer

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Researcher

Inge Van de Walle

Awards & Distinctions

36 Results

2023

Intrathymic dendritic cell-biased precursors promote human T cell lineage specification through IRF8-driven transmembrane TNF

Kai Ling LiangJuliette RoelsMarieke LavaertTom PuttemanLena BöhmeLaurentijn TillemanImke VelgheValentina PegorettiInge Van de WalleStephanie Sontag et al.

A1 Journal Article in NATURE IMMUNOLOGY

2022

Identification and purification of human T cell precursors

Inge Van de WalleNina LambrechtsAnaïs DerveeuwMarieke LavaertJuliette RoelsTom Taghon

Bookchapter in T-cell development : methods and protocols

2020

PHF6 expression levels impact human hematopoietic stem cell differentiation

Siebe LoontiensAnne-Catherine DolensSteven StrubbeInge Van de WalleFinola E. MooreLisa DepestelSuzanne VanhauwaertFilip MatthijssensDavid M. LangenauFranki Speleman et al.

A1 Journal Article in FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

2018

Scrutinizing PHF6 regulatory networks in T-ALL and normal hematopoiesis using zebrafish

Siebe LoontiensKaat DurinckInge Van de WalleFinola MooreSuzanne VanhauwaertEls JanssensGivani DewynLisa DepestelChristophe Van NesteDavid Langenau et al.

2016

A quantitative proteomics approach identifies ETV6 and IKZF1 as new regulators of an ERG-driven transcriptional network

Ashwin UnnikrishnanYi Fang GuanYizhou HuangDominik BeckJulie AI ThomsSofie PeirsKathy KnezevicShiyong MaInge Van de WalleIneke de Jong et al.

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Approaches to study human T cell development

Anne-Catherine DolensInge Van de WalleTom Taghon

Bookchapter in T-Cell development : methods and protocols

CRISPR-Cas9 modeling of cell lines and zebrafish to study the TLX1-PHF6 cooperative interrelationship in T-cell acute lymphoblastic leukemia

Siebe LoontiensKaat DurinckNina De RockerAnnekatrien BoelEls JanssensSuzanne VanhauwaertPieter RondouCharles De BockInge Van de WalleFinola Moore et al.

Characterization and isolation of human T cell progenitors

Inge Van de WalleKarin DavidsTom Taghon

Bookchapter in T-Cell development : methods and protocols

Expanding the TLX1 regulome in T-cell acute lymphoblastic leukemia towards long noncoding RNAs

Kaat DurinckWouter Van LoockeInge Van de WalleJoni Van der MeulenPieter-Jan VoldersNadine Van RoyYves BenoitBruce PoppePieter MestdaghJo Vandesompele et al.

GATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fate

Inge Van de WalleAnne-Catherine DolensKaat DurinckKatrien De MulderWouter Van LoockeSagar DamleEls WaegemansJelle De MedtsImke VelgheMagda De Smedt et al.

A1 Journal Article in NATURE COMMUNICATIONS

Long noncoding RNA signatures define oncogenic subtypes in T-cell acute lymphoblastic leukemia

Annelynn WallaertKaat DurinckWouter Van LoockeInge Van de WalleFilip MatthijssensPieter-Jan VoldersFrancisco Avila CobosDries RombautPieter RondouPieter Mestdagh et al.

A1 Journal Article in LEUKEMIA

Modeling the TLX1-PHF6 cooperative interrelationship in T-cell acute lymphoblastic leukemia in zebrafish

Siebe LoontiensKaat DurinckELS JANSSENSSuzanne VanhauwaertPieter RondouJan CoolsCharles De BockInge Van de WalleFinola MooreDavid Langenau et al.

The T-ALL oncogene TLX1 controls enhancer lncRNA expression

Karen VerboomKaat DurinckWouter Van LoockeFilip MatthijssensInge Van de WalleAnnelynn WallaertPieter-Jan VoldersNadine Van RoyYves BenoitBruce Poppe et al.

2015

Characterization of the genome-wide TLX1 binding profile in T-cell acute lymphoblastic leukemia

Kaat DurinckWouter Van LoockeJoni Van der MeulenInge Van de WalleMaté OngenaertPieter RondouAnnelynn WallaertCE de BockNadine Van RoyBruce Poppe et al.

A1 Journal Article in LEUKEMIA

Epigenetics in T-cell acute lymphoblastic leukemia

Sofie PeirsJoni Van der MeulenInge Van de WalleTom TaghonFranki SpelemanBruce PoppePieter Van Vlierberghe

A1 Journal Article in IMMUNOLOGICAL REVIEWS

MicroRNA-193b-3p acts as a tumor suppressor by targeting the MYB oncogene in T-cell acute lymphoblastic leukemia

Evelien MetsJoni Van der MeulenGert Van PeerMichael BoicePieter MestdaghInge Van de WalleTim LammensSteven GoossensBarbara De MoerlooseYves Benoit et al.

A1 Journal Article in LEUKEMIA

Transcriptional antagonism between the cooperative oncogenes TLX1 and NOTCH1 in T-cell acute lymphoblastic leukemia.

Kaat DurinckWouter Van LoockeJoni Van der MeulenInge Van de WallePieter RondouCharles E De BockBruce PoppeJan CoolsJean SoulierTom Taghon et al.

2014

ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensSteven GoossensInge Van de WalleKatia RuggeroCharles E de BockSandrine DegryseKirsten Canté-BarrettDelphine BriotEmmanuelle Clappier et al.

A1 Journal Article in BLOOD

ABT-199 mediated inhibition of BCL2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensSteven GoossensCharles De BockKirsten Canté-BarrettTim LammensInge Van de WalleBarbara De MoerlooseYves BenoitBruce Poppe et al.

Integrative analysis of the NOTCH1 regulatory network identifies key downstream lncRNAs in acute T-cell lymphoblastic leukemia and normal T-cell development

Annelynn WallaertKaat DurinckPieter RondouInge Van de WalleWouter Van LoockePieter-Jan VoldersMaté OngenaertNadine Van RoyBruce PoppeYves Benoit et al.

Notch3 activation is sufficient but not required for inducing human T-lineage specification

Els WaegemansInge Van de WalleJelle De MedtsMagda De SmedtTessa KerreBart VandekerckhoveGeorges LeclercqTao WangJean PlumTom Taghon

A1 Journal Article in JOURNAL OF IMMUNOLOGY

The NOTCH1 driven long non-coding RNA repertoire in T-cell acute lymphoblastic leukemia

Annelynn WallaertKaat DurinckPieter RondouInge Van de WalleWouter VanloockePieter-Jan VoldersSuzanne VanhauwaertEllen GeerdensMaté OngenaertNadine Van Roy et al.

The Notch driven long non-coding RNA repertoire in T-cell acute lymphoblastic leukemia

Kaat DurinckAnnelynn WallaertInge Van de WalleWouter Van LoockePieter-Jan VoldersSuzanne VanhauwaertEllen GeerdensYves BenoitNadine Van RoyBruce Poppe et al.

A1 Journal Article in HAEMATOLOGICA

The first lncRNA landscape of major genetic T-ALL subsets and guilt-by-association analysis for ETP-ALL specific lncRNAs

Annelynn WallaertKaat DurinckWouter Van LoockePieter-Jan VoldersInge Van de WalleYves BenoitBruce PoppeJo VandesompeleTom TaghonJean Soulier et al.

2013

Primate lentiviral Nef proteins deregulate T-cell development by multiple mechanisms

Anouk Van NuffelKevin AriënVeronique StoveMichael SchindlerEduardo O'NeillJan SchmökelInge Van de WalleEvelien NaessensHanne VanderstraetenKathleen Van Landeghem et al.

A1 Journal Article in RETROVIROLOGY

Specific Notch receptor-ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength

Inge Van de WalleEls WaegemansJelle De MedtsGreet De SmetMagda De SmedtSylvia SnauwaertBart VandekerckhoveTessa KerreGeorges LeclercqJean Plum et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

2012

Intrinsic dynamics of the fat graft: in vitro interactions between the main cell actors

Maarten DoornaertHeidi DeclercqFilip StillaertBernard DepypereInge Van de WalleMaria CornelissenPhillip Blondeel

A1 Journal Article in PLASTIC AND RECONSTRUCTIVE SURGERY

Notch ligands control the human alpha beta/gamma delta lineage choice through receptor-specific induction of differential Notch signal strength

Tom TaghonInge Van de WalleEls WaegemansJelle De MedtsGreet De SmetMagda De SmedtBart VandekerckhoveTessa KerreGeorges LeclercqTao Wang et al.

Notch signaling during human T cell development

Tom TaghonEls WaegemansInge Van de Walle

A1 Journal Article in Current Topics in Microbiology and Immunology

2011

Jagged2 acts as a Delta-like Notch ligand during early hematopoietic cell fate decisions

Inge Van de WalleGreet De SmetMartina GärtnerMagda De SmedtEls WaegemansBart VandekerckhoveGeorges LeclercqJean PlumJon C AsterIrwin D Bernstein et al.

A1 Journal Article in BLOOD

2009

An early decrease in Notch activation is required for human TCR-αβ lineage differentiation at the expense of TCR-γδ T cells

Inge Van de WalleGreet De SmetMagda De SmedtBart VandekerckhoveGeorges LeclercqJean PlumTom Taghon

A1 Journal Article in BLOOD

Notch signaling is required for proliferation but not for differentiation at a well-defined β-selection checkpoint during human T-cell development

Tom TaghonInge Van de WalleGreet De SmetMagda De SmedtGeorges LeclercqBart VandekerckhoveJean Plum

A1 Journal Article in BLOOD

2008

Stage-dependent molecular changes in Notch signaling are critical for normal human T cell development

Tom TaghonInge Van de WalleGreet De SmetMagda De SmedtJean Plum

2007

Notch signaling induces cytoplasmic CD3 epsilon expression in human differentiating NK cells

Magda De SmedtTom TaghonInge Van de WalleGreet De SmetGeorges LeclercqJean Plum

A1 Journal Article in BLOOD

2006

Overexpression of HES-1 is not sufficient to impose T-cell differentiation on human hernatopoietic stem cells

Inge HoebekeMagda De SmedtInge Van de WalleKatia ReynvoetGreet De SmetJean PlumGeorges Leclercq

A1 Journal Article in BLOOD

2005

Human immunodeficiency virus Nef induces rapid internalization of the T-cell coreceptor CD8 alpha beta

Veronique StoveInge Van de WalleEvelien NaessensElisabeth CoeneChristophe StoveJean PlumBruno Verhasselt

A1 Journal Article in JOURNAL OF VIROLOGY