Research Explorer

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Researcher

Ineke Dhondt

Awards & Distinctions

23 Results

2023

Adult-restricted gene knock-down reveals candidates that affect locomotive healthspan in C. elegans

Areta JushajMatthew ChurginMiguel De La TorreAmanda KieswetterBrecht DriesschaertIneke DhondtBart BraeckmanChristopher Fang-YenLiesbet Temmerman

A1 Journal Article in BIOGERONTOLOGY

2022

Accumulation of glycogen and upregulation of LEA-1 in C. elegans daf-2(e1370) support stress resistance, not longevity

Aleksandra ZečićIneke DhondtBart Braeckman

A1 Journal Article in CELLS

Axenic culture of Caenorhabditis elegans alters lysosomal/proteasomal balance and increases neuropeptide expression

Huaihan CaiPing WuLieselot VandemeulebrouckeIneke DhondtMadina RasulovaAndy VierstraeteBart Braeckman

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Identification of healthspan-promoting genes in Caenorhabditis elegans based on a human GWAS study

Nadine SaulIneke DhondtMikko KuokkanenMarkus PerolaClara VerschuurenBrecht WoutersHenrik von ChrzanowskiWinnok H. De VosLiesbet TemmermanWalter Luyten et al.

A1 Journal Article in BIOGERONTOLOGY

2021

Elevated trehalose levels in C. elegans daf-2 mutants increase stress resistance, not lifespan

Madina RasulovaAleksandra ZečićJose Manuel Monje MorenoLieselot VandemeulebrouckeIneke DhondtBart Braeckman

A1 Journal Article in METABOLITES

Prediction of biological age by morphological staging of sarcopenia in Caenorhabditis elegans

Ineke DhondtClara VerschuurenAleksandra ZečićTim LoierBart BraeckmanWinnok H. De Vos

A1 Journal Article in DISEASE MODELS & MECHANISMS

2019

CBP-1 acts in GABAergic neurons to double life span in axenically cultured Caenorhabditis elegans

Huaihan CaiIneke DhondtLieselot VandemeulebrouckeCaroline VlaeminckMadina RasulovaBart Braeckman

A1 Journal Article in JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The nutritional requirements of Caenorhabditis elegans

Aleksandra ZečićIneke DhondtBart Braeckman

A1 Journal Article in GENES AND NUTRITION

2018

Ancient origin of the CARD-coiled coil/Bcl10/MALT1-like paracaspase signaling complex indicates unknown critical functions

Jens StaalYasmine DriegeMira HaegmanAlice BorghiPaco HulpiauLaurens LievensIsmail Sahin GülSrividhya Sundararaman IyerAmanda GonçalvesIneke Dhondt et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Bioassay-guided isolation of three anthelmintic compounds from Warburgia ugandensis Sprague subspecies ugandensis, and the mechanism of action of polygodial

Maoxuan LiuPurity KipangaAnh Hung MaiIneke DhondtBart BraeckmanWim De BorggraeveWalter Luyten

A1 Journal Article in INTERNATIONAL JOURNAL FOR PARASITOLOGY

2017

Changes of protein turnover in aging Caenorhabditis elegans

Ineke DhondtVladislav A PetyukSophie BauerHeather M BrewerRichard D SmithGeert DepuydtBart Braeckman

A1 Journal Article in MOLECULAR & CELLULAR PROTEOMICS

Life-span extension by axenic dietary restriction is independent of the mitochondrial unfolded protein response and mitohormesis in Caenorhabditis elegans

Huaihan CaiMadina RasulovaLieselot VandemeulebrouckeLea Marie MeagherCaroline VlaeminckIneke DhondtBart Braeckman

A1 Journal Article in JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Lifespan extension in Caenorhabditis elegans insulin/IGF-1 signalling mutants is supported by non-vertebrate physiological traits

Bart BraeckmanIneke Dhondt

A1 Journal Article in NEMATOLOGY

2016

FOXO/DAF-16 activation slows down turnover of the majority of proteins in C. elegans

Ineke DhondtVladislav A PetyukHuaihan CaiLieselot VandemeulebrouckeAndy VierstraeteRichard D SmithGeert DepuydtBart Braeckman

A1 Journal Article in CELL REPORTS

Increased protein stability and decreased protein turnover in the Caenorhabditis elegans Ins/IGF-1 daf-2 mutant

Geert DepuydtNilesh ShanmugamMadina RasulovaIneke DhondtBart Braeckman

A1 Journal Article in JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Proteome-wide changes in protein turnover rates in C. elegans models of longevity and age-related disease

Marieke VisscherSasha De HenauMattheus HE WildschutRobert M van EsIneke DhondtHelen MichelsPatrick KemmerenEllen A NollenBart BraeckmanBoudewijn MT Burgering et al.

A1 Journal Article in CELL REPORTS

2015

Comparative metabolomic profiling reveals that dysregulated glycolysis stemming from lack of salvage NAD⁺ biosynthesis impairs reproductive development in Caenorhabditis elegans

Wenqing WangMelanie R McReynoldsJimmy F GoncalvesMuya ShuIneke DhondtBart BraeckmanStephanie E LangeKelvin KhoAriana C DetwilerMarisa J Pacella et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Patterns of protein turnover in aging Caenorhabditis elegans

Ineke DhondtBart BraeckmanGeert Depuydt

2014

Mitochondrial efficiency is increased in axenically cultured Caenorhabditis elegans

Natascha CasteleinMichael MuscholIneke DhondtHuaihan CaiWinnok De VosNorbert A DencherBart Braeckman

A1 Journal Article in EXPERIMENTAL GERONTOLOGY

2013

Reduced insulin/insulin-like growth factor-1 signaling and dietary restriction inhibit translation but preserve muscle mass in Caenorhabditis elegans

Geert DepuydtFang XieVladislav A PetyukNilesh ShanmugamArne SmoldersIneke DhondtHeather M BrewerDavid G CampRichard D SmithBart Braeckman

A1 Journal Article in MOLECULAR & CELLULAR PROTEOMICS

2012

Measurement of S-phase duration of adult stem cells in the flatworm Macrostomum lignano by double replication labelling and quantitative colocalization analysis

Freija VerdoodtMaxime WillemsIneke DhondtWouter HouthoofdWim BertWinnok De Vos

A1 Journal Article in CELL BIOLOGY INTERNATIONAL

2010

Establishing a flatworm ageing model

Stijn MoutonFreija VerdoodtMaxime WillemsIneke DhondtJeroen CruckeBart BraeckmanWouter Houthoofd

Editorial material

2009

Macrostomum lignano: an emerging model for studying the reciprocal influence between tissue homeostasis and ageing

Stijn MoutonFreija VerdoodtMaxime WillemsIneke DhondtJeroen CruckeGaetan BorgonieWouter Houthoofd