Research Explorer

Your browser does not support JavaScript or JavaScript is not enabled. Without JavaScript some functions of this webapplication may be disabled or cause error messages. To enable JavaScript, please consult the manual of your browser or contact your system administrator.

Researcher

Huybrecht T'jollyn

Awards & Distinctions

10 Results

2019

PBPK and its virtual populations : the impact of physiology on pediatric pharmacokinetic predictions of tramadol

Huybrecht T'jollynAn VermeulenJan Van Bocxlaer

A1 Journal Article in AAPS JOURNAL

2018

A physiologically based pharmacokinetic perspective on the clinical utility of albumin-based dose adjustments in critically ill patients

Huybrecht T'jollynAn VermeulenJan Van BocxlaerPieter Colin

A1 Journal Article in CLINICAL PHARMACOKINETICS

2017

Strategies for determining correct cytochrome P450 contributions in hepatic clearance predictions : in vitro-in vivo extrapolation as modelling approach and tramadol as proof-of concept compound

Huybrecht T'jollynJan SnoeysJan Van BocxlaerLies De BockPieter AnnaertAchiel Van PeerKarel AllegaertGeert MannensAn VermeulenKoen Boussery

A1 Journal Article in EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

2016

Characterizing hepatic clearance in early life : PBPK as modelling tool and tramadol as guide

Huybrecht T'jollynJan Van BocxlaerAn VermeulenKoen Boussery

2015

Physiologically based pharmacokinetic predictions of tramadol exposure throughout pediatric life: an analysis of the different clearance contributors with emphasis on CYP2D6 maturation

Huybrecht T'jollynJan SnoeysAn VermeulenRobin MicheletFilip CuykensGeert MannensAchiel Van PeerPieter AnnaertKarel AllegaertJan Van Bocxlaer et al.

A1 Journal Article in AAPS JOURNAL

Physiology-based IVIVE predictions of tramadol from in vitro metabolism data

Huybrecht T'jollynJan SnoeysPieter ColinJan Van BocxlaerPieter AnnaertFilip CuyckensAn VermeulenAchiel Van PeerKarel AllegaertGeert Mannens et al.

A1 Journal Article in PHARMACEUTICAL RESEARCH

2014

Moxifloxacin dosing in post-bariatric surgery patients

Pieter ColinDouglas J EleveldMichel StruysHuybrecht T'jollynLucas Van BortelJohannes RuigeJan De WaeleJan Van BocxlaerKoen Boussery

A1 Journal Article in BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

2013

Development and validation of a fast and uniform approach to quantify β-lactam antibiotics in human plasma by solid phase extraction-liquid chromatography-electrospray-tandem mass spectrometry

Pieter ColinLies De BockHuybrecht T'jollynKoen BousseryJan Van Bocxlaer

A1 Journal Article in TALANTA

2012

Development and validation of a fast and sensitive UPLC-MS/MS method for the quantification of six probe metabolites for the in vitro determination of cytochrome P450 activity

Lies De BockKoen BousseryPieter ColinJulie De SmetHuybrecht T'jollynJan Van Bocxlaer

A1 Journal Article in TALANTA

2011

Evaluation of three state-of-the-art metabolite prediction software packages (Meteor, MetaSite, and StarDrop) through independent and synergistic use

Huybrecht T'jollynKoen BousseryRJ Mortishire-SmithK CoeB De BoeckJan Van BocxlaerG Mannens

A1 Journal Article in DRUG METABOLISM AND DISPOSITION