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Researcher
Hristo Svilenov
Profile
Projects
Publications & Research Data
Activities
Awards & Distinctions
Patents
29
Results
2025
Color flow imaging microscopy improves identification of stress sources of protein aggregates in biopharmaceuticals
Michaela Cohrs
Shiwoo Koak
Yejin Lee
Yu Jin Sung
Wesley De Neve
Hristo Svilenov
Utku Özbulak
P1
Conference
2025
Impact of pneumatic tube transportation on the aggregation of monoclonal antibodies in clinical practice
Michaela Cohrs
Nele Clottens
Pieter Ramaut
Kevin Braeckmans
Stefaan De Smedt
Tieneke Bauters
Hristo Svilenov
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
2025
Intrinsic differential scanning fluorimetry for protein stability assessment in microwell plates
Michaela Cohrs
Alastair Davy
Manon Van Ackere
Stefaan De Smedt
Kevin Braeckmans
Markus Epe
Hristo Svilenov
A1
Journal Article
in
MOLECULAR PHARMACEUTICS
2025
Risk assessment of pneumatic tube systems for in-hospital transportation of biotherapeutics
Michaela Cohrs
Paula E. Borgonje
Nele Clottens
Pieter Ramaut
Kevin Braeckmans
Stefaan De Smedt
Hristo Svilenov
Tieneke Bauters
A1
Journal Article
in
JOURNAL OF ONCOLOGY PHARMACY PRACTICE
2025
2023
Antibodies gone bad : the molecular mechanism of light chain amyloidosis
Ramona M. Absmeier
Georg J. Rottenaicher
Hristo Svilenov
Pamina Kazman
Johannes Buchner
A1
Journal Article
in
FEBS JOURNAL
2023
Approaches to expand the conventional toolbox for discovery and selection of antibodies with drug-like physicochemical properties
Hristo Svilenov
Paolo Arosio
Tim Menzen
Peter Tessier
Pietro Sormanni
A1
Journal Article
in
MABS
2023
Get what you want : identifying antibodies against pre-defined epitopes on Frizzled receptors
Hristo Svilenov
Editorial material
2023
Insights into the stabilization of interferon alpha by two surfactants revealed by STD-NMR spectroscopy
Hristo Svilenov
Katharina T. Kopp
Alexander P. Golovanov
Gerhard Winter
Matja Zalar
A1
Journal Article
in
JOURNAL OF PHARMACEUTICAL SCIENCES
2023
Principles of antibodies with ultralong complementarity-determining regions and picobodies
Marcel Fridolin Passon
Stefaan De Smedt
Hristo Svilenov
A1
Journal Article
in
BIOTECHNOLOGY ADVANCES
2023
2022
It is never too late for a cocktail : development and analytical characterization of fixed-dose antibody combinations
Dennis Krieg
Gerhard Winter
Hristo Svilenov
A1
Journal Article
in
JOURNAL OF PHARMACEUTICAL SCIENCES
2022
Multimeric ACE2-IgM fusions as broadly active antivirals that potently neutralize SARS-CoV-2 variants
Hristo Svilenov
Romina Bester
Julia Sacherl
Ramona Absmeier
Carsten Peters
Ulrike Protzer
Carsten Brockmeyer
Johannes Buchner
A1
Journal Article
in
COMMUNICATIONS BIOLOGY
2022
2021
Combining unfolding reversibility studies and molecular dynamics simulations to select aggregation-resistant antibodies
Carolin Berner
Tim Menzen
Gerhard Winter
Hristo Svilenov
A1
Journal Article
in
MOLECULAR PHARMACEUTICS
2021
Mechanistic principles of an ultra-long bovine CDR reveal strategies for antibody design
Hristo Svilenov
Julia Sacherl
Ulrike Protzer
Martin Zacharias
Johannes Buchner
A1
Journal Article
in
NATURE COMMUNICATIONS
2021
Picomolar inhibition of SARS-CoV-2 variants of concern by an engineered ACE2-IgG4-Fc fusion protein
Hristo Svilenov
Julia Sacherl
Alwin Reiter
Lisa S. Wolff
Cho-Chin Cheng
Marcel Stern
Vincent Grass
Martin Feuerherd
Frank-Peter Wachs
Nicole Simonavicius
et al.
A1
Journal Article
in
ANTIVIRAL RESEARCH
2021
2020
Advancing therapeutic protein discovery and development through comprehensive computational and biophysical characterization
Lorenzo Gentiluomo
Hristo Svilenov
Dillen Augustijn
Inas El Bialy
Maria Laura Greco
Alina Kulakova
Sowmya Indrakumar
Sujata Mahapatra
Marcello Martinez Morales
Christin Pohl
et al.
A1
Journal Article
in
MOLECULAR PHARMACEUTICS
2020
Binding of excipients is a poor predictor for aggregation kinetics of biopharmaceutical proteins
Matja Zalar
Hristo Svilenov
Alexander P. Golovanov
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2020
Biophysical characterization of binary therapeutic monoclonal antibody mixtures
Dennis Krieg
Carolin Berner
Gerhard Winter
Hristo Svilenov
A1
Journal Article
in
MOLECULAR PHARMACEUTICS
2020
Formulations that suppress aggregation during long-term storage of a bispecific antibody are characterized by high refoldability and colloidal stability
Hristo Svilenov
Gerhard Winter
A1
Journal Article
in
JOURNAL OF PHARMACEUTICAL SCIENCES
2020
Modulated scanning fluorimetry can quickly assess thermal protein unfolding reversibility in microvolume samples
Hristo Svilenov
Tim Menzen
Klaus Richter
Gerhard Winter
A1
Journal Article
in
MOLECULAR PHARMACEUTICS
2020
Orthogonal techniques to study the effect of pH, sucrose, and arginine salts on monoclonal antibody physical stability and aggregation during long-term storage
Hristo Svilenov
Alina Kulakova
Matja Zalar
Alexander P. Golovanov
Pernille Harris
Gerhard Winter
A1
Journal Article
in
JOURNAL OF PHARMACEUTICAL SCIENCES
2020
Overcoming challenges in co-formulation of proteins with contradicting stability profiles: EPO plus G-CSF
Dennis Krieg
Hristo Svilenov
Julian H. Gitter
Gerhard Winter
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
2020
Protein analytics : analytical methods for coformulations of therapeutic proteins
Dennis Krieg
Hristo Svilenov
Julian Gitter
A2
Journal Article
in
PZ PRISMA
2020
2019
Application of interpretable artificial neural networks to early monoclonal antibodies development
Lorenzo Gentiluomo
Dierk Roessner
Dillen Augustijn
Hristo Svilenov
Alina Kulakova
Sujata Mahapatra
Gerhard Winter
Werner Streicher
Åsmund Rinnan
Günther H.J. Peters
et al.
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2019
Novel non-linear curve fitting to resolve protein unfolding transitions in intrinsic fluorescence differential scanning fluorimetry
Dillen Augustijn
Sujata Mahapatra
Werner Streicher
Hristo Svilenov
Alina Kulakova
Christin Pohl
Åsmund Rinnan
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2019
Rapid sample-saving biophysical characterisation and long-term storage stability of liquid interferon alpha2a formulations : is there a correlation?
Hristo Svilenov
Gerhard Winter
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2019
Structure-based discovery of a new protein-aggregation breaking excipient
Andreas Tosstorff
Hristo Svilenov
Günther H.J. Peters
Pernille Harris
Gerhard Winter
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2019
The ReFOLD assay for protein formulation studies and prediction of protein aggregation during long-term storage
Hristo Svilenov
Gerhard Winter
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2019
2018
A new approach to study the physical stability of monoclonal antibody formulations : dilution from a denaturant
Hristo Svilenov
Lorenzo Gentiluomo
Wolfgang Friess
Dierk Roessner
Gerhard Winter
A1
Journal Article
in
JOURNAL OF PHARMACEUTICAL SCIENCES
2018
Isothermal chemical denaturation as a complementary tool to overcome limitations of thermal differential scanning fluorimetry in predicting physical stability of protein formulations
Hristo Svilenov
Uroš Markoja
Gerhard Winter
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2018