Research Explorer

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Researcher

Hendrik Feys

Awards & Distinctions

72 Results

2025

The impact of amotosalen photochemical pathogen inactivation on human platelet lysate

Willem DelabieDominique De BleserVicky VandewalleMarie-Laurence De PrestPhilippe VandekerckhoveVeerle CompernolleHendrik Feys

A1 Journal Article in CURRENT STEM CELL RESEARCH & THERAPY

2024

Biochemical rationale for transfusion of high titre COVID-19 convalescent plasma

Caro VerbruggheElise WoutersRosalie DevlooVisa NurmiSabrina SeghersDominique De BleserHeli HarvalaVeerle CompernolleHendrik Feys

A1 Journal Article in SCIENTIFIC REPORTS

Differential composition and yield of leukocytes isolated from various blood component leukoreduction filters

Katrijn SixSarah VertongenSabrina SeghersDominique De BleserVeerle CompernolleHendrik Feys

A1 Journal Article in JOURNAL OF IMMUNOLOGICAL METHODS

Platelet additive solutions SSP+ and T-PAS+ are interchangeable for platelet concentrate storage despite differences in composition and plasticizer

Britt Van AelstKaren BensBea SabotSarah VertongenHendrik FeysVeerle CompernolleKatrijn R Six

A1 Journal Article in TRANSFUSION MEDICINE AND HEMOTHERAPY

Shedding light on GPIbα shedding

Caitlin DebaeneHendrik FeysKatrijn Six

A1 Journal Article in CURRENT OPINION IN HEMATOLOGY

Towards standardized human platelet lysate production in Europe : an initiative of the European Blood Alliance

Dirk De KorteWillem DelabieHendrik FeysThomas KleiRune LarsenÓlafur SigurjónssonAna Paula SousaEuropean Blood Alliance

A1 Journal Article in VOX SANGUINIS

2023

GPIbα shedding in platelets is controlled by strict intracellular containment of both enzyme and substrate

Katrijn SixCaitlin DebaeneMichelle Van den HauweRiet De RyckeElizabeth E. GardinerVeerle CompernolleHendrik Feys

A1 Journal Article in JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Intranasal administration of convalescent plasma protects against SARS-CoV-2 infection in hamsters

Elise WoutersCaro VerbruggheRana AbdelnabiRosalie DevlooDorien De ClippelDirk JochmansDominique De BleserBirgit WeynandVeerle CompernolleJohan Neyts et al.

A1 Journal Article in EBIOMEDICINE

Single step method for high yield human platelet lysate production

Willem DelabieDominique De BleserVicky VandewallePhilippe VandekerckhoveVeerle CompernolleHendrik Feys

A1 Journal Article in TRANSFUSION

2022

ADAMTS13 inhibition to treat acquired von Willebrand syndrome during mechanical circulatory support device implantation

SJ DeconinckC NixS BarthE Bennek-SchöppingA RauchAS SchelpeE RooseHendrik FeysI PareynA Vandenbulcke et al.

A1 Journal Article in JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Multinational analysis of children transfused with pathogen inactivated platelets

M DelaneyJ AndrewsM VirkJR BarberJE BostJ BaechHendrik Feys

A2 Journal Article in HOSPITAL PEDIATRICS

2021

A novel competition ELISA for the rapid quantification of SARS-CoV-2 neutralizing antibodies in convalescent plasma

Elise WoutersCaro VerbruggheRosalie DevlooIsabelle DebruyneDorien De ClippelLeen Van HeddegemKristin Van AschVeronique Van GaverMiek VanbrabantAn Muylaert et al.

A1 Journal Article in TRANSFUSION

Determination of anti‐ADAMTS13 autoantibody titers in ELISA : influence of ADAMTS13 presentation and autoantibody detection

Charlotte DekimpeElien RooseKadri KangroQuintijn BonnezAline VandenbulckeEdwige TellierGilles KaplanskiHendrik FeysClaudia TersteegAndres Männik et al.

A1 Journal Article in JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Evaluation of SARS‐CoV‐2 antibody titers and potency for convalescent plasma donation : a brief commentary

Elise WoutersMaurice SteenhuisHubert SchrezenmeierPierre TiberghienHeli HarvalaHendrik FeysEllen Schoot

Editorial material

Immunogenic hotspots in the spacer domain of ADAMTS13 in immune‐mediated thrombotic thrombocytopenic purpura

Leydi Carolina Velásquez PereiraElien RooseNuno A. G. GraçaGyörgy SinkovitsKadri KangroBérangère S. JolyEdwige TellierGilles KaplanskiTanja FalterCharis Von Auer et al.

A1 Journal Article in JOURNAL OF THROMBOSIS AND HAEMOSTASIS

SARS-CoV-2 neutralising antibody testing in Europe : towards harmonisation of neutralising antibody titres for better use of convalescent plasma and comparability of trial data

D NguyenP SimmondsM SteenhuisE WoutersD DesmechtM GariglianyM RomanoC BarbezangeP MaesB Van Holm et al.

A1 Journal Article in EUROSURVEILLANCE

The need for and challenges of comparing SARS-CoV-2 antibody assays

C JacquotHendrik Feys

Editorial material

Tuning the surface interactions between single cells and an OSTE+ microwell array for enhanced single cell manipulation

Jolien BreukersSara HortaCaroline StruyfsDragana SpasicHendrik FeysNick GeukensKarin ThevissenBruno P.A. CammueKaren VanhoorelbekeJeroen Lammertyn

A1 Journal Article in ACS APPLIED MATERIALS & INTERFACES

2020

Innovations in platelet transfusion medicine

Katrijn SixHendrik FeysVeerle CompernolleKatrien Devreese

Open ADAMTS13, induced by antibodies, is a biomarker for subclinical immune-mediated thrombotic thrombocytopenic purpura

Elien RooseAn-Sofie TellierEdwige TellierGyörgy SinkovitsBérangère S JolyCharlotte DekimpeGilles KaplanskiMaelle Le BesneraisIlaria ManciniDr. Tanja Falter et al.

A1 Journal Article in BLOOD

Platelet Biochemistry and Morphology after Cryopreservation

Katrijn SixHendrik FeysVeerle Compernolle

A1 Journal Article in International Journal of Molecular Sciences

The senotherapeutic nicotinamide riboside raises platelet nicotinamide adenine dinucleotide levels but cannot prevent storage lesion

W DelabieW MaesR DevlooMR Van den HauweK VanhoorelbekeVeerle CompernolleHendrik Feys

A1 Journal Article in TRANSFUSION

When platelets are left in the cold

Katrijn SixVeerle CompernolleHendrik Feys

A2 Journal Article in ANNALS OF BLOOD

2019

A comparison of haematopoietic stem cells from umbilical cord blood and peripheral blood for platelet production in a microfluidic device

Katrijn SixGeraldine SicotRosalie DevlooHendrik FeysDominique BaruchVeerle Compernolle

A1 Journal Article in VOX SANGUINIS

Biomolecular consequences of platelet pathogen inactivation methods

Hendrik FeysBritt Van AelstVeerle Compernolle

A1 Journal Article in TRANSFUSION MEDICINE REVIEWS

Impact of cold storage on platelets treated with Intercept pathogen inactivation

Katrijn SixRosalie DevlooVeerle CompernolleHendrik Feys

A1 Journal Article in TRANSFUSION

The ice recrystallization inhibitor polyvinyl alcohol does not improve platelet cryopreservation

Katrijn SixStijn LyssensRosalie DevlooVeerle CompernolleHendrik Feys

A1 Journal Article in TRANSFUSION

2018

Comparison between manufacturing sites shows differential adhesion, activation, and GPIbα expression of cryopreserved platelets

Katrijn SixWillem DelabieKatrien DevreeseLacey JohnsonDenese MarksLarry DumontVeerle CompernolleHendrik Feys

A1 Journal Article in TRANSFUSION

Comparison of three commercially available buffy coat pooling sets for the preparation of platelet concentrates

Hendrik FeysR DevlooB SabotJ CoeneVeerle Compernolle

A1 Journal Article in VOX SANGUINIS

Major changes of von Willebrand factor multimer distribution in cirrhotic patients with stable disease or acute decompensation

Eszter PalyuJolan HarsfalviTamas TornaiMaria PappMiklos UdvardyKatalin Szekeres-CsikiLajos PatakiKaren VanhoorelbekeHendrik FeysHans Deckmyn et al.

A1 Journal Article in THROMBOSIS AND HAEMOSTASIS

2017

A microfluidic flow chamber model for platelet transfusion and hemostasis measures platelet deposition and fibrin formation in real-time

Katrijn SixRosalie DevlooBritt Van AelstPhilippe VandekerckhoveHendrik FeysVeerle Compernolle

A1 Journal Article in JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

High platelet content can increase storage lesion rates following Intercept pathogen inactivation primarily in platelet concentrates prepared by apheresis

Hendrik FeysR DevlooB SabotK De PourcqJ CoeneVeerle Compernolle

A1 Journal Article in VOX SANGUINIS

2016

Microfluidic flow chambers using reconstituted blood to model hemostasis and platelet transfusion in vitro

Britt Van AelstHendrik FeysRosalie DevlooPhilippe VandekerckhoveVeerle Compernolle

A1 Journal Article in JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

Persistent aggregates in apheresis platelet concentrates are commonly collected from donors with a history of aggregate donation

Hendrik FeysH PottelJ CoeneG VandewallePhilippe VandekerckhoveVeerle Compernolle

A1 Journal Article in VOX SANGUINIS

Psoralen and ultraviolet A light treatment directly affects phosphatidylinositol 3-kinase signal transduction by altering plasma membrane packing

Britt Van AelstRosalie DevlooPierre ZachéeRuben t'KindtKoen SandraPhilippe VandekerckhoveVeerle CompernolleHendrik Feys

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

The contribution of von Willebrand factor-GPIbα interactions to persistent aggregate formation in apheresis platelet concentrates

Hendrik FeysBritt Van AelstRosalie DevlooPhilippe VandekerckhoveVeerle Compernolle

A1 Journal Article in VOX SANGUINIS

2015

Aggregates in platelet concentrates

PF van der MeerLJ DumontM LozanoN BondarJ WongS IsmayJ PinkW NussbaumerJ CoeneHendrik Feys et al.

A1 Journal Article in VOX SANGUINIS

Linker regions and flexibility around the metalloprotease domain account for conformational activation of ADAMTS-13

L DeforcheE RooseA VandenbulckeN VandeputteHendrik FeysTA SpringerLZ MiJ MuiaJE SadlerK Soejima et al.

A1 Journal Article in JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Observational study of corrected count increments after transfusion of platelets treated with riboflavin pathogen reduction technology in additive solutions

SM DrawzS MarschnerM YañezA García de CocaHendrik FeysD DeerenJ Coene

A1 Journal Article in TRANSFUSION

Persistent aggregates in apheresis platelet concentrates

Hendrik FeysJosé CoeneRosalie DevlooBritt Van AelstH PottelPhilippe VandekerckhoveVeerle Compernolle

A1 Journal Article in VOX SANGUINIS

Riboflavin and amotosalen photochemical treatments of platelet concentrates reduce thrombus formation kinetics in vitro

Britt Van AelstHendrik FeysRosalie DevlooK VanhoorelebekePhilippe VandekerckhoveVeerle Compernolle

A1 Journal Article in VOX SANGUINIS

Ultraviolet C light pathogen inactivation treatment of platelet concentrates preserves integrin activation but affects thrombus formation kinetics on collagen in vitro

Britt Van AelstRosalie DevlooPhilippe VandekerckhoveVeerle CompernolleHendrik Feys

A1 Journal Article in TRANSFUSION

2014

Allosteric activation of ADAMTS13 by von Willebrand factor

Joshua MuiaJian ZhuGarima GuptaSandra L HaberichterKenneth D FriedmanHendrik FeysLouis DeforcheKaren VanhoorelbekeLisa A WestfieldRobyn Roth et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxygen removal during pathogen inactivation with riboflavin and UV light preserves protein function in plasma for transfusion

Hendrik FeysBritt Van AelstKatrien DevreeseRosalie DevlooJ CoenePhilippe VandekerckhoveVeerle Compernolle

A1 Journal Article in VOX SANGUINIS

Paired analysis of plasma proteins and coagulant capacity after treatment with three methods of pathogen reduction

José CoeneKatrien DevreeseBea SabotHendrik FeysPhilippe VandekerckhoveVeerle Compernolle

A1 Journal Article in TRANSFUSION

Screening for HLA antibodies in plateletpheresis donors with a history of transfusion or pregnancy

Dorien De ClippelMartine BaetenAnneleen TorfsMarie-Paule EmondsHendrik FeysPhilippe VandekerckhoveVeerle Compernolle

A1 Journal Article in TRANSFUSION

2013

Nitric oxide levels increase during platelet concentrate production from buffy coats, but not during storage

Hendrik FeysPhilippe VandekerckhoveVeerle Compernolle

A1 Journal Article in TRANSFUSION

2012

Blood platelet biochemistry

Katleen BroosSimon F De MeyerHendrik FeysKaren VanhoorelbekeHans Deckmyn

A1 Journal Article in THROMBOSIS RESEARCH

Inhibition of von Willebrand factor-platelet glycoprotein Ib interaction prevents and reverses symptoms of acute acquired thrombotic thrombocytopenic purpura in baboons

Hendrik FeysJan RoodtNele VandeputteInge PareynHarald MottlSam HouSeb LamprechtWalter J Van RensburgHans DeckmynKaren Vanhoorelbeke

A1 Journal Article in BLOOD

2011

Local elongation of endothelial cell-anchored von Willebrand factor strings precedes ADAMTS13 protein-mediated proteolysis

Karen De CeunynckSusana RochaHendrik FeysSimon F De MeyerHiroshi Uji-iHans DeckmynJohan HofkensKaren Vanhoorelbeke

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Platelets at work in primary hemostasis

Katleen BroosHendrik FeysSimon F De MeyerKaren VanhoorelbekeHans Deckmyn

A1 Journal Article in BLOOD REVIEWS

Residues Arg568 and Phe592 contribute to an antigenic surface for anti-ADAMTS13 antibodies in the spacer domain

Wouter PosNicoletta SorvilloRob FijnheerHendrik FeysPaul HP KaijenGestur VidarssonJan Voorberg

A1 Journal Article in HAEMATOLOGICA-THE HEMATOLOGY JOURNAL

2010

Active platelet-binding conformation of plasma von Willebrand factor in young women with acute myocardial infarction

F PeyvandiMJ HollestelleR PallaPA MerliniHendrik FeysK VanhoorelbekePJ LentingPM Mannucci

A1 Journal Article in JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Inactivation of ADAMTS13 by plasmin as a potential cause of thrombotic thrombocytopenic purpura

Hendrik FeysN VandeputteR PallaF PeyvandiK PeerlinckH DeckmynHR LijnenK Vanhoorelbeke

A1 Journal Article in JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The distal carboxyterminal domains of murine ADAMTS13 influence proteolysis of platelet-decorated VWF strings in vivo

B De MaeyerSF De MeyerHendrik FeysI PareynN VandeputteH DeckmynK Vanhoorelbeke

A1 Journal Article in JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Thrombotic thrombocytopenic purpura directly linked with ADAMTS13 inhibition in the baboon (Papio ursinus)

Hendrik FeysJan RoodtNele VandeputteInge PareynSeb LamprechtWalter J Van RensburgPatricia J AndersonUlrich BuddeVernon J LouwPhilip N Badenhorst et al.

A1 Journal Article in BLOOD

2009

ADAMTS13 in health and disease

Hendrik FeysHans DeckmynKaren Vanhoorelbeke

A1 Journal Article in ACTA HAEMATOLOGICA

ADAMTS13's tail tale

Karen VanhoorelbekeHendrik FeysSimon F De Meyer

Editorial material

Multi-step binding of ADAMTS-13 to von Willebrand factor

Hendrik FeysPJ AndersonK VanhoorelbekeEM MajerusJE Sadler

A1 Journal Article in JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Mutation of the H-bond acceptor S119 in the ADAMTS13 metalloprotease domain reduces secretion and substrate turnover in a patient with congenital thrombotic thrombocytopenic purpura

Hendrik FeysInge PareynRenée VancraenenbroeckMarc De MaeyerHans DeckmynChris Van GeetKaren Vanhoorelbeke

A1 Journal Article in BLOOD

2008

ADAMTS13 and anti-ADAMTS13 antibodies as markers for recurrence of acquired thrombotic thrombocytopenic purpura during remission

Flora PeyvandiSilvia LavoretanoRoberta PallaHendrik FeysKaren VanhoorelbekeTullia BattaglioliCarla ValsecchiMaria Teresa CancianiFabrizio FabrisSamo Zver et al.

A1 Journal Article in HAEMATOLOGICA-THE HEMATOLOGY JOURNAL

Inherited traits affecting platelet function

Isabelle I SallesHendrik FeysBrecht F IserbytSimon F De MeyerKaren VanhoorelbekeHans Deckmyn

A1 Journal Article in BLOOD REVIEWS

2007

ADAMTS13 activity to antigen ratio in physiological and pathological conditions associated with an increased risk of thrombosis

Hendrik FeysMaria T CancianiFlora PeyvandiHans DeckmynKaren VanhoorelbekePier M Mannucci

A1 Journal Article in BRITISH JOURNAL OF HAEMATOLOGY

Decreased ADAMTS-13 (A disintegrin-like and metalloprotease with thrombospondin type 1 repeats) is associated with a poor prognosis in sepsis-induced organ failure

Kenneth MartinDelphine BorgelNicolas LerolleHendrik FeysLudovic TrinquartKaren VanhoorelbekeHans DeckmynPaulette LegendreJean-Luc DiehlDominique Baruch

A1 Journal Article in CRITICAL CARE MEDICINE

Factor XI/ADAMTS13 complexes are quantitatively insignificant in human plasma

Patricia J AndersonDavid GailaniHendrik FeysWeiqiang GaoElaine M MajerusKaren VanhoorelbekeJ Evan Sadler

A1 Journal Article in HAEMATOLOGICA-THE HEMATOLOGY JOURNAL

2006

ADAMTS-13 plasma level determination uncovers antigen absence in acquired thrombotic thrombocytopenic purpura and ethnic differences

Hendrik FeysF LiuN DongI PareynS VauterinN VandeputteW NoppeC RuanH DeckmynK Vanhoorelbeke

A1 Journal Article in JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Alteration of ADAMTS13 antigen levels in patients with idiopathic thrombotic thrombocytopenic purpura, idiopathic thrombocytopenic purpura and systemic lupus erythematosus

F LiuHendrik FeysNZ DongYM ZhaoCG Ruan

A1 Journal Article in THROMBOSIS AND HAEMOSTASIS

Development of monoclonal antibodies that inhibit platelet adhesion or aggregation as potential anti-thrombotic drugs

SF De MeyerK VanhoorelbekeH UlrichtsS StaelensHendrik FeysI SallesA FontayneH Deckmyn

A2 Journal Article in CARDIOVASCULAR & HEMATOLOGICAL DISORDERS. DRUG TARGETS

Thrombospondin-1 controls vascular platelet recruitment and thrombus adherence in mice by protecting (sub)endothelial VWF from cleavage by ADAMTS13

A BonnefoyK DaenensHendrik FeysR De VosP VandervoortJ VermylenJ LawlerMF Hoylaerts

A1 Journal Article in BLOOD

[A clinical study of congenital thrombotic thrombocytopenic purpura]

F LiuNZ DongJ JinHendrik FeysX BaiCG Ruan

A2 Journal Article in ZHONGHUA NEI KE ZA ZHI = CHINESE JOURNAL OF INTERNAL MEDICINE

[Determination of the ADAMTS13 antigen and its activity in TTP patients and carriers]

F LiuHendrik FeysNZ DongX BaiK VanhoorelbekeH DeckmynCG Ruan

A2 Journal Article in ZHONGHUA XUEYEXUE ZAZHI = CHINESE JOURNAL OF HEMATOLOGY

2004

Monoclonal antibody IAC-1 is specific for activated α2β1 and binds to amino acids 199 to 201 of the integrin α2 I-domain

A SchoolmeesterK VanhoorelbekeS KatsutaniH DepraetereHendrik FeysJMW HeemskerkMF HoylaertsH Deckmyn

A1 Journal Article in BLOOD