Research Explorer

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Researcher

Heleen Dewitte

Awards & Distinctions

40 Results

2023

Nanobody-mediated SPECT/CT imaging reveals the spatiotemporal expression of programmed death-ligand 1 in response to a CD8+ T cell and iNKT cell activating mRNA vaccine

Thomas ErtveldtSofie MeulewaeterYannick De VlaeminckOscar OlarteKatrijn BroosSerge Van CalenberghStephanie BourgeoisJoke DeprezYves HeremansCleo Goyvaerts et al.

A1 Journal Article in THERANOSTICS

Transport by circulating myeloid cells drives liposomal accumulation in inflamed synovium

Joke DeprezRein VerbekeSofie MeulewaeterIlke AernoutHeleen DewitteTine DecruyJulie CoudenysJulie Van DuyseGert Van IsterdaelDan Peer et al.

A1 Journal Article in NATURE NANOTECHNOLOGY

2022

Evaluation of liposome-loaded microbubbles as a theranostic tool in a murine collagen-induced arthritis model

Joke DeprezSilke RooversGuillaume LajoinieHeleen DewitteTine DecruyJulie CoudenysBenedicte DescampsChristian VanhoveMichel VersluisDirk Elewaut et al.

A2 Journal Article in SCIENTIA PHARMACEUTICA

2021

Hydrogel-induced cell membrane disruptions enable direct cytosolic delivery of membrane-impermeable cargo

Jelter Van HoeckThijs Van de VyverAranit HarizajGlenn GoetgelukPieterjan MerckxJing LiuMike WelsFélix SauvageHerlinde De KeersmaeckerChristian Vanhove et al.

A1 Journal Article in ADVANCED MATERIALS

The dawn of mRNA vaccines : the COVID-19 case

Rein VerbekeIne LentackerStefaan De SmedtHeleen Dewitte

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

mRNA in cancer immunotherapy : beyond a source of antigen

Lien Van HoeckeRein VerbekeHeleen DewitteIne LentackerKarim VermaelenKarine BreckpotSandra Van Lint

A1 Journal Article in MOLECULAR CANCER

2020

Ultrasound-responsive cavitation nuclei for therapy and drug delivery

Klazina KooimanSilke RooversSimone A. G. LangeveldRobert T. KlevenHeleen DewitteMeaghan A. O'ReillyJean-Michel EscoffreAyache BouakazMartin D. VerweijKullervo Hynynen et al.

A1 Journal Article in ULTRASOUND IN MEDICINE AND BIOLOGY

mRNA encoding a bispecific single domain antibody construct protects against influenza A virus infection in mice

Lien Van HoeckeRein VerbekeDorien De VliegerHeleen DewitteKenny RooseSharon Van NevelOlga KryskoClaus BachertBert SchepensIne Lentacker et al.

A1 Journal Article in MOLECULAR THERAPY-NUCLEIC ACIDS

2019

Broadening the message : a nanovaccine co-loaded with messenger RNA and α-GalCer induces antitumor immunity through conventional and natural killer T cells

Rein VerbekeIne LentackerKarine BreckpotJonas JanssensSerge Van CalenberghStefaan De SmedtHeleen Dewitte

A1 Journal Article in ACS NANO

Design of messenger RNA lipid nanoparticles for cancer immunotherapy

Rein VerbekeStefaan De SmedtHeleen Dewitte

Enhancing nucleic acid delivery with ultrasound and microbubbles

Heleen DewitteSilke RooversStefaan De SmedtIne Lentacker

Bookchapter in Nanotechnology for nucleic acid delivery : methods and protocols

Non-viral delivery of chemically modified mRNA to the retina : subretinal versus intravitreal administration

Joke DevoldereKaren PeynshaertHeleen DewitteChristian VanhoveLies De GroefLieve MoonsSinem Yilmaz ÖzcanDeniz DalkaraStefaan De SmedtKatrien Remaut

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Sonoprinting of nanoparticle-loaded microbubbles : unraveling the multi-timescale mechanism

Silke RooversGuillaume LajoinieIne De CockToon BransHeleen DewitteKevin BraeckmansMichel VersuisStefaan De SmedtIne Lentacker

A1 Journal Article in BIOMATERIALS

The obstacle course to the inner retina : hyaluronic acid-coated lipoplexes cross the vitreous but fail to overcome the inner limiting membrane

Joke DevoldereMike WelsKaren PeynshaertHeleen DewitteStefaan De SmedtKatrien Remaut

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Three decades of messenger RNA vaccine development

Rein VerbekeIne LentackerStefaan De SmedtHeleen Dewitte

A1 Journal Article in NANO TODAY

2018

Non-spherical oscillations drive the ultrasound-mediated release from targeted microbubbles

Guillaume LajoinieYing LuanErik GelderblomBenjamin DolletFrits MastikHeleen DewitteIne LentackerNico de JongMichel Versluis

A1 Journal Article in COMMUNICATIONS PHYSICS

Optimized messenger RNA immunolipoplexes for cancer immunotherapy : balancing immunogenicity and adjuvancy

Rein VerbekeIne LentackerKarine BreckpotSerge Van CalenberghStefaan De SmedtHeleen Dewitte

Quantifying the average number of nucleic acid therapeutics per nanocarrier by single particle tracking microscopy

Elisa ZagatoLotte VermeulenHeleen DewitteGriet Van ImschootRoosmarijn VandenbrouckeJo DemeesterStefaan De SmedtKristiaan NeytsKatrien RemautKevin Braeckmans

A1 Journal Article in MOLECULAR PHARMACEUTICS

2017

Co-delivery of nucleoside-modified mRNA and TLR agonists for cancer immunotherapy : restoring the immunogenicity of immunosilent mRNA

Rein VerbekeIne LentackerLaura WayteckKarine BreckpotMieke Van BockstalBenedicte DescampsChristian VanhoveStefaan De SmedtHeleen Dewitte

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Co-delivery of nucleoside-modified mRNA and immunomodulators for cancer immunotherapy: restoring the immunogenicity of immunosilent mRNA

Rein VerbekeIne LentackerLaura WayteckKarine BreckpotBenedicte DescampsChristian VanhoveStefaan De SmedtHeleen Dewitte

mRNA-based nanoparticles for therapeutic cancer vaccination

Rein VerbekeLaura WayteckKarine BreckpotChristian VanhoveBenedicte DescampsStefaan De SmedtHeleen DewitteIne Lentacker

2016

Evading innate immunity in nonviral mRNA delivery : don't shoot the messenger

Joke DevoldereHeleen DewitteStefaan De SmedtKatrien Remaut

A1 Journal Article in DRUG DISCOVERY TODAY

Hitchhiking nanoparticles: reversible coupling of lipid-based nanoparticles to cytotoxic T lymphocytes

Laura WayteckHeleen DewitteLynn De BackerKarine BreckpotJo DemeesterStefaan De SmedtKoen Raemdonck

A1 Journal Article in BIOMATERIALS

Particle-mediated intravenous delivery of antigen mRNA results in strong antigen-specific T-cell responses despite the induction of type I interferon

Katrijn BroosKevin VanderjeughtJanik PuttemansCleo GoyvaertsCarlo HeirmanHeleen DewitteRein VerbekeIne LentackerKris ThielemansKarine Breckpot

A2 Journal Article in MOLECULAR THERAPY-NUCLEIC ACIDS

2015

Combinatorial strategies for the induction of immunogenic cell death

Lucillia BezuLigia C Gomes-da-SilvaHeleen DewitteKarine BreckpotJitka FucikovaRadek SpisekLorenzo GalluzziOliver KeppGuido Kroemer

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Design and evaluation of immunotherapeutic imaging for cancer vaccination

Heleen DewitteStefaan De SmedtKarine BreckpotIne Lentacker

Evaluation of mRNA lipoplexes for single-step antigen loading and maturation of dendritic cells in cancer immunotherapy

Rein VerbekeHeleen DewitteIne LentackerStefaan De Smedt

Immunogenic mRNA nanoparticles for dendritic cell-based cancer vaccination

Rein VerbekeHeleen DewitteIne LentackerStefaan De Smedt

Microbubbles as magic bullets in cancer immunotherapy

Heleen DewitteSandra Van LintKatrien VanderperrenHendrik HaersEmmelie StockStefaan De SmedtKarine BreckpotIne Lentacker

The ReNAissanCe of mRNA-based cancer therapy

Sandra Van LintDries RenmansKatrijn BroosHeleen DewitteIne LentackerCarlo HeirmanKarine BreckpotKris Thielemans

A1 Journal Article in EXPERT REVIEW OF VACCINES

Theranostic mRNA-loaded microbubbles in the lymphatics of dogs: implications for drug delivery

Heleen DewitteKatrien VanderperrenHendrik HaersEmmelie StockLuc DuchateauMyriam HestaJimmy SaundersStefaan De SmedtIne Lentacker

A1 Journal Article in THERANOSTICS

2014

Choose your models wisely: how different murine bone marrow-derived dendritic cell protocols influence the success of nanoparticulate vaccines in vitro

Heleen DewitteRein VerbekeKarine BreckpotRoosmarijn VandenbrouckeClaude LibertStefaan De SmedtIne Lentacker

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Nanoparticle design to induce tumor immunity and challenge the suppressive tumor microenvironment

Heleen DewitteRein VerbekeKarine BreckpotStefaan De SmedtIne Lentacker

A1 Journal Article in NANO TODAY

The bubble breakthrough in cancer immunotherapy

Heleen DewitteSandra Van LintKatrien VanderperrenStefaan De SmedtKarine BreckpotIne Lentacker

The bubble breakthrough in cancer immunotherapy : Mma-sonoporation in dendritic cell-based cancer vaccination

Heleen DewitteSandra Van LintKatrien VanderperrenKris ThielemansStefaan De SmedtKarine BreckpotIne Lentacker

The bubble breakthrough in cancer immunotherapy : Mma-sonoporation in dendritic cell-based cancer vaccination

Heleen DewitteSandra Van LintKatrien VanderperrenKris ThielemansStefaan De SmedtKarine BreckpotIne Lentacker

The potential of antigen and TriMix sonoporation using mRNA-loaded microbubbles for ultrasound-triggered cancer immunotherapy

Heleen DewitteSandra Van LintCarlo HeirmanKris ThielemansStefaan De SmedtKarine BreckpotIne Lentacker

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

2013

Design and evaluation of theranostic perfluorocarbon particles for simultaneous antigen-loading and 19F-MRI tracking of dendritic cells

Heleen DewitteBart GeersSayuan LiangUwe HimmelreichJo DemeesterStefaan De SmedtIne Lentacker

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

2012

Crucial factors and emerging concepts in ultrasound-triggered drug delivery

Bart GeersHeleen DewitteStefaan De SmedtIne Lentacker

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

2011

mRNA-Lipoplex loaded microbubble contrast agents for ultrasound-assisted transfection of dendritic cells

Marie-Luce De TemmermanHeleen DewitteRoosmarijn VandenbrouckeBart LucasClaude LibertJo DemeesterStefaan De SmedtIne LentackerJoanna Rejman

A1 Journal Article in BIOMATERIALS