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Researcher
Heleen Dewitte
Profile
Projects
Publications & Research Data
Activities
Awards & Distinctions
Patents
42
Results
2023
Nanobody-mediated SPECT/CT imaging reveals the spatiotemporal expression of programmed death-ligand 1 in response to a CD8+ T cell and iNKT cell activating mRNA vaccine
Thomas Ertveldt
Sofie Meulewaeter
Yannick De Vlaeminck
Oscar Olarte
Katrijn Broos
Serge Van Calenbergh
Stephanie Bourgeois
Joke Deprez
Yves Heremans
Cleo Goyvaerts
et al.
A1
Journal Article
in
THERANOSTICS
2023
Transport by circulating myeloid cells drives liposomal accumulation in inflamed synovium
Joke Deprez
Rein Verbeke
Sofie Meulewaeter
Ilke Aernout
Heleen Dewitte
Tine Decruy
Julie Coudenys
Julie Van Duyse
Gert Van Isterdael
Dan Peer
et al.
A1
Journal Article
in
NATURE NANOTECHNOLOGY
2023
2022
Evaluation of liposome-loaded microbubbles as a theranostic tool in a murine collagen-induced arthritis model
Joke Deprez
Silke Roovers
Guillaume Lajoinie
Heleen Dewitte
Tine Decruy
Julie Coudenys
Benedicte Descamps
Christian Vanhove
Michel Versluis
Dirk Elewaut
et al.
A2
Journal Article
in
SCIENTIA PHARMACEUTICA
2022
2021
Hydrogel-induced cell membrane disruptions enable direct cytosolic delivery of membrane-impermeable cargo
Jelter Van Hoeck
Thijs Van de Vyver
Aranit Harizaj
Glenn Goetgeluk
Pieterjan Merckx
Jing Liu
Mike Wels
Félix Sauvage
Herlinde De Keersmaecker
Christian Vanhove
et al.
A1
Journal Article
in
ADVANCED MATERIALS
2021
mRNA in cancer immunotherapy : beyond a source of antigen
Lien Van Hoecke
Rein Verbeke
Heleen Dewitte
Ine Lentacker
Karim Vermaelen
Karine Breckpot
Sandra Van Lint
A1
Journal Article
in
MOLECULAR CANCER
2021
The dawn of mRNA vaccines : the COVID-19 case
Rein Verbeke
Ine Lentacker
Stefaan De Smedt
Heleen Dewitte
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2021
2020
mRNA encoding a bispecific single domain antibody construct protects against influenza A virus infection in mice
Lien Van Hoecke
Rein Verbeke
Dorien De Vlieger
Heleen Dewitte
Kenny Roose
Sharon Van Nevel
Olga Krysko
Claus Bachert
Bert Schepens
Ine Lentacker
et al.
A1
Journal Article
in
MOLECULAR THERAPY-NUCLEIC ACIDS
2020
Ultrasound-responsive cavitation nuclei for therapy and drug delivery
Klazina Kooiman
Silke Roovers
Simone A. G. Langeveld
Robert T. Kleven
Heleen Dewitte
Meaghan A. O'Reilly
Jean-Michel Escoffre
Ayache Bouakaz
Martin D. Verweij
Kullervo Hynynen
et al.
A1
Journal Article
in
ULTRASOUND IN MEDICINE AND BIOLOGY
2020
2019
Broadening the message : a nanovaccine co-loaded with messenger RNA and α-GalCer induces antitumor immunity through conventional and natural killer T cells
Rein Verbeke
Ine Lentacker
Karine Breckpot
Jonas Janssens
Serge Van Calenbergh
Stefaan De Smedt
Heleen Dewitte
A1
Journal Article
in
ACS NANO
2019
Design of messenger RNA lipid nanoparticles for cancer immunotherapy
Rein Verbeke
Stefaan De Smedt
Heleen Dewitte
Dissertation
2019
Enhancing nucleic acid delivery with ultrasound and microbubbles
Heleen Dewitte
Silke Roovers
Stefaan De Smedt
Ine Lentacker
Bookchapter
in
Nanotechnology for nucleic acid delivery : methods and protocols
2019
Non-viral delivery of chemically modified mRNA to the retina : subretinal versus intravitreal administration
Joke Devoldere
Karen Peynshaert
Heleen Dewitte
Christian Vanhove
Lies De Groef
Lieve Moons
Sinem Yilmaz Özcan
Deniz Dalkara
Stefaan De Smedt
Katrien Remaut
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2019
Sonoprinting of nanoparticle-loaded microbubbles : unraveling the multi-timescale mechanism
Silke Roovers
Guillaume Lajoinie
Ine De Cock
Toon Brans
Heleen Dewitte
Kevin Braeckmans
Michel Versuis
Stefaan De Smedt
Ine Lentacker
A1
Journal Article
in
BIOMATERIALS
2019
The obstacle course to the inner retina : hyaluronic acid-coated lipoplexes cross the vitreous but fail to overcome the inner limiting membrane
Joke Devoldere
Mike Wels
Karen Peynshaert
Heleen Dewitte
Stefaan De Smedt
Katrien Remaut
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2019
Three decades of messenger RNA vaccine development
Rein Verbeke
Ine Lentacker
Stefaan De Smedt
Heleen Dewitte
A1
Journal Article
in
NANO TODAY
2019
2018
Non-spherical oscillations drive the ultrasound-mediated release from targeted microbubbles
Guillaume Lajoinie
Ying Luan
Erik Gelderblom
Benjamin Dollet
Frits Mastik
Heleen Dewitte
Ine Lentacker
Nico de Jong
Michel Versluis
A1
Journal Article
in
COMMUNICATIONS PHYSICS
2018
Optimized messenger RNA immunolipoplexes for cancer immunotherapy : balancing immunogenicity and adjuvancy
Rein Verbeke
Ine Lentacker
Karine Breckpot
Serge Van Calenbergh
Stefaan De Smedt
Heleen Dewitte
C3
Conference
2018
Quantifying the average number of nucleic acid therapeutics per nanocarrier by single particle tracking microscopy
Elisa Zagato
Lotte Vermeulen
Heleen Dewitte
Griet Van Imschoot
Roosmarijn Vandenbroucke
Jo Demeester
Stefaan De Smedt
Kristiaan Neyts
Katrien Remaut
Kevin Braeckmans
A1
Journal Article
in
MOLECULAR PHARMACEUTICS
2018
2017
Co-delivery of nucleoside-modified mRNA and immunomodulators for cancer immunotherapy: restoring the immunogenicity of immunosilent mRNA
Rein Verbeke
Ine Lentacker
Laura Wayteck
Karine Breckpot
Benedicte Descamps
Christian Vanhove
Stefaan De Smedt
Heleen Dewitte
C3
Conference
2017
Co-delivery of nucleoside-modified mRNA and TLR agonists for cancer immunotherapy : restoring the immunogenicity of immunosilent mRNA
Rein Verbeke
Ine Lentacker
Laura Wayteck
Karine Breckpot
Mieke Van Bockstal
Benedicte Descamps
Christian Vanhove
Stefaan De Smedt
Heleen Dewitte
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2017
mRNA-based nanoparticles for therapeutic cancer vaccination
Rein Verbeke
Laura Wayteck
Karine Breckpot
Christian Vanhove
Benedicte Descamps
Stefaan De Smedt
Heleen Dewitte
Ine Lentacker
C3
Conference
2017
2016
Evading innate immunity in nonviral mRNA delivery : don't shoot the messenger
Joke Devoldere
Heleen Dewitte
Stefaan De Smedt
Katrien Remaut
A1
Journal Article
in
DRUG DISCOVERY TODAY
2016
Hitchhiking nanoparticles: reversible coupling of lipid-based nanoparticles to cytotoxic T lymphocytes
Laura Wayteck
Heleen Dewitte
Lynn De Backer
Karine Breckpot
Jo Demeester
Stefaan De Smedt
Koen Raemdonck
A1
Journal Article
in
BIOMATERIALS
2016
Particle-mediated intravenous delivery of antigen mRNA results in strong antigen-specific T-cell responses despite the induction of type I interferon
Katrijn Broos
Kevin Vanderjeught
Janik Puttemans
Cleo Goyvaerts
Carlo Heirman
Heleen Dewitte
Rein Verbeke
Ine Lentacker
Kris Thielemans
Karine Breckpot
A2
Journal Article
in
MOLECULAR THERAPY-NUCLEIC ACIDS
2016
2015
Combinatorial strategies for the induction of immunogenic cell death
Lucillia Bezu
Ligia C Gomes-da-Silva
Heleen Dewitte
Karine Breckpot
Jitka Fucikova
Radek Spisek
Lorenzo Galluzzi
Oliver Kepp
Guido Kroemer
A1
Journal Article
in
FRONTIERS IN IMMUNOLOGY
2015
Design and evaluation of immunotherapeutic imaging for cancer vaccination
Heleen Dewitte
Stefaan De Smedt
Karine Breckpot
Ine Lentacker
Dissertation
2015
Evaluation of mRNA lipoplexes for single-step antigen loading and maturation of dendritic cells in cancer immunotherapy
Rein Verbeke
Heleen Dewitte
Ine Lentacker
Stefaan De Smedt
C3
Conference
2015
Immunogenic mRNA nanoparticles for dendritic cell-based cancer vaccination
Rein Verbeke
Heleen Dewitte
Ine Lentacker
Stefaan De Smedt
C3
Conference
2015
Microbubbles as magic bullets in cancer immunotherapy
Heleen Dewitte
Sandra Van Lint
Katrien Vanderperren
Hendrik Haers
Emmelie Stock
Stefaan De Smedt
Karine Breckpot
Ine Lentacker
C3
Conference
2015
The ReNAissanCe of mRNA-based cancer therapy
Sandra Van Lint
Dries Renmans
Katrijn Broos
Heleen Dewitte
Ine Lentacker
Carlo Heirman
Karine Breckpot
Kris Thielemans
A1
Journal Article
in
EXPERT REVIEW OF VACCINES
2015
Theranostic mRNA-loaded microbubbles in the lymphatics of dogs: implications for drug delivery
Heleen Dewitte
Katrien Vanderperren
Hendrik Haers
Emmelie Stock
Luc Duchateau
Myriam Hesta
Jimmy Saunders
Stefaan De Smedt
Ine Lentacker
A1
Journal Article
in
THERANOSTICS
2015
2014
Choose your models wisely: how different murine bone marrow-derived dendritic cell protocols influence the success of nanoparticulate vaccines in vitro
Heleen Dewitte
Rein Verbeke
Karine Breckpot
Roosmarijn Vandenbroucke
Claude Libert
Stefaan De Smedt
Ine Lentacker
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2014
Nanoparticle design to induce tumor immunity and challenge the suppressive tumor microenvironment
Heleen Dewitte
Rein Verbeke
Karine Breckpot
Stefaan De Smedt
Ine Lentacker
A1
Journal Article
in
NANO TODAY
2014
The bubble breakthrough in cancer immunotherapy
Heleen Dewitte
Sandra Van Lint
Katrien Vanderperren
Stefaan De Smedt
Karine Breckpot
Ine Lentacker
C3
Conference
2014
The bubble breakthrough in cancer immunotherapy : Mma-sonoporation in dendritic cell-based cancer vaccination
Heleen Dewitte
Sandra Van Lint
Katrien Vanderperren
Kris Thielemans
Stefaan De Smedt
Karine Breckpot
Ine Lentacker
C3
Conference
2014
The bubble breakthrough in cancer immunotherapy : Mma-sonoporation in dendritic cell-based cancer vaccination
Heleen Dewitte
Sandra Van Lint
Katrien Vanderperren
Kris Thielemans
Stefaan De Smedt
Karine Breckpot
Ine Lentacker
C3
Conference
2014
The potential of antigen and TriMix sonoporation using mRNA-loaded microbubbles for ultrasound-triggered cancer immunotherapy
Heleen Dewitte
Sandra Van Lint
Carlo Heirman
Kris Thielemans
Stefaan De Smedt
Karine Breckpot
Ine Lentacker
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2014
2013
Design and evaluation of theranostic perfluorocarbon particles for simultaneous antigen-loading and 19F-MRI tracking of dendritic cells
Heleen Dewitte
Bart Geers
Sayuan Liang
Uwe Himmelreich
Jo Demeester
Stefaan De Smedt
Ine Lentacker
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2013
Liposome shedding from a vibrating microbubble on nanoseconds timescale
Ying Luan
Guillaume Lajoinie
Erik Gelderblom
Ilya Skachkov
Heleen Dewitte
Ine Lentacker
Tom van Rooij
Hendrik Vos
Ton van der Steen
Michel Versluis
et al.
P1
Conference
2013
2012
Characterizing ultrasound-controlled drug release by high-speed fluorescence imaging
Ying Luan
Erik Gelderblom
Guillaume Lajoinie
Ilya Skachkov
Heleen Dewitte
Bart Geers
Ine Lentacker
Ton van der Steen
Michel Versluis
Nico de Jong
P1
Conference
2012
Crucial factors and emerging concepts in ultrasound-triggered drug delivery
Bart Geers
Heleen Dewitte
Stefaan De Smedt
Ine Lentacker
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2012
2011
mRNA-Lipoplex loaded microbubble contrast agents for ultrasound-assisted transfection of dendritic cells
Marie-Luce De Temmerman
Heleen Dewitte
Roosmarijn Vandenbroucke
Bart Lucas
Claude Libert
Jo Demeester
Stefaan De Smedt
Ine Lentacker
Joanna Rejman
A1
Journal Article
in
BIOMATERIALS
2011