Research Explorer

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Researcher

Hanne Van Gorp

Awards & Distinctions

40 Results

2023

Complex regulation of alarmins S100A8/A9 and secretion via gasdermin D pores exacerbates autoinflammation in familial Mediterranean fever

Selina K. JorchAnnika McNallyPhilipp BergerJonas WolfKim KaiserAndrian Chetrusca CovashStefanie RobeckIsabell PastauOlesja FehlerSaskia-L. Jauch-Speer et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The autoinflammation-associated NLRC4<SUP>V341A</SUP> mutation increases microbiota-independent IL-18 production but does not recapitulate human autoinflammatory symptoms in mice

Elien EeckhoutTomoko AsaokaHanne Van GorpDieter DemonCharlotte Girard-Guyonvarc'hVanessa AndriesLars VereeckeCem GabayMohamed LamkanfiGeert van Loo et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

2022

Bacillus anthracis induces NLRP3 inflammasome activation and caspase-8-mediated apoptosis of macrophages to promote lethal anthrax

Filip Van HauwermeirenNina Van OpdenboschHanne Van GorpNathalia de VasconcelosGeert van LooPeter VandenabeeleThirumala-Devi KannegantiMohamed Lamkanfi

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GSDMD drives canonical inflammasome-induced neutrophil pyroptosis and is dispensable for NETosis

Dhruv ChauhanDieter DemonLieselotte Vande WalleOonagh PaerewijckAnnalisa ZecchinLeslie BosselerKarin SantoniRemi PlanesSilvia Ribó GenéAmelie Fossoul et al.

A1 Journal Article in EMBO REPORTS

2020

An apoptotic caspase network safeguards cell death induction in pyroptotic macrophages

Nathalia Moraes de VasconcelosNina Van OpdenboschHanne Van GorpRosa Martin-PerezAnnalisa ZecchinPeter VandenabeeleMohamed Lamkanfi

A1 Journal Article in CELL REPORTS

Blood-based test for diagnosis and functional subtyping of familial Mediterranean fever

Hanne Van GorpLinyan HuangPedro Henrique Viana SaavedraMarnik VuylstekeTomoko AsaokaGiusi PrencipeAntonella InsalacoBenson OgunjimiJerold JeyaratnamIlaria Cataldo et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

2019

A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation

Simon TavernierV AthanasopoulosPATRICK VERLOOG BehrensJens StaalDelfien BogaertLeslie NaesensMarieke De BruyneSofie Van GassenEef Parthoens et al.

A1 Journal Article in NATURE COMMUNICATIONS

Inflammasome-dependent cytokines at the crossroads of health and autoinflammatory disease

Hanne Van GorpNina Van OpdenboschMohamed Lamkanfi

A1 Journal Article in COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY

Protein crystallization promotes type 2 immunity and is reversible by antibody treatment

Emma PerssonKenneth VerstraeteInes HeyndrickxElien GevaertHelena Catharine AegerterJean-Michel PercierKim DeswarteKoen VerschuerenAnn DansercoerDelphine Gras et al.

A1 Journal Article in SCIENCE

Single-cell analysis of pyroptosis dynamics reveals conserved GSDMD-mediated subcellular events that precede plasma membrane rupture

Nathalia Moraes de VasconcelosNina Van OpdenboschHanne Van GorpEef ParthoensMohamed Lamkanfi

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

The emerging roles of inflammasome-dependent cytokines in cancer development

Hanne Van GorpMohamed Lamkanfi

A1 Journal Article in EMBO REPORTS

2018

GSDMD is critical for autoinflammatory pathology in a mouse model of Familial Mediterranean Fever

Apurva KannegantiRK Subbarao MalireddiPedro Henrique Viana SaavedraLieselotte Vande WalleHanne Van GorpHiroto KambaraHeather TillmanPeter VogelHongbo R LuoRamnik J Xavier et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

2017

Caspase-1 engagement and TLR-induced c-FLIP expression suppress ASC/caspase-8-dependent apoptosis by inflammasome sensors NLRP1b and NLRC4

Nina Van OpdenboschHanne Van GorpMaarten VerdoncktPedro Henrique Viana SaavedraNathalia Moraes de VasconcelosAmanda GonçalvesLieselotte Vande WalleDieter DemonMagdalena MatusiakFilip Van Hauwermeiren et al.

A1 Journal Article in CELL REPORTS

2016

Development and characterization of new species cross-reactive anti-sialoadhesin monoclonal antibodies

Marjorie De SchryverHanne Van GorpInge HoebekeBauke De MaeyerKaren OomsIsabel PintelonLouis J MaesPaul CosHans NauwynckPeter L Delputte

A2 Journal Article in ANTIBODIES

Does caspase-12 suppress inflammasome activation?

Lieselotte Vande WalleDaniel Jiménez FernandezDieter DemonNaomi Van LaethemFilip Van HauwermeirenHanne Van GorpNina Van OpdenboschNobuhiko KayagakiMohamed Lamkanfi

A1 Journal Article in NATURE

Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation

Hanne Van GorpPedro Henrique Viana SaavedraNathalia Moraes de VasconcelosNina Van OpdenboschLieselotte Vande WalleMagdalena MatusiakGiusi PrencipeAntonella InsalacoFilip Van HauwermeirenDieter Demon et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammasomes in inflammatory disease

Hanne Van GorpPedro Henrique Viana SaavedraNathalia Moraes de VasconcelosNina Van OpdenboschLieselotte Vande WalleMagdalena MatusiakFilip Van HauwermeirenG. PrencipeDelfien BogaertMelissa Dullaers et al.

2015

Protective and detrimental roles of inflammasomes in disease

Pedro Henrique Viana SaavedraDieter DemonHanne Van GorpMohamed Lamkanfi

A1 Journal Article in SEMINARS IN IMMUNOPATHOLOGY

2014

NOD-like receptors interfacing the immune and reproductive systems

Hanne Van GorpAnna KuchmiyFilip Van HauwermeirenMohamed Lamkanfi

A1 Journal Article in FEBS JOURNAL

2013

Development of a recombinant antibody to target peptides and proteins to sialoadhesin-expressing macrophages

Karen OomsHanne Van GorpTim Van GaeverHans NauwynckPeter Delputte

A1 Journal Article in BMC BIOTECHNOLOGY

Evaluation of viral peptide targeting to porcine sialoadhesin using a porcine reproductive and respiratory syndrome virus vaccination-challenge model

Karen OomsHanne Van GorpSara BottiTim Van GaeverPeter DelputteHans Nauwynck

A1 Journal Article in VIRUS RESEARCH

Porcine, murine and human sialoadhesin (Sn/Siglec-1/CD169): portals for porcine reproductive and respiratory syndrome virus entry into target cells

Wander Van BreedamMieke VerbeeckIsaura ChristiaensHanne Van GorpHans Nauwynck

A1 Journal Article in JOURNAL OF GENERAL VIROLOGY

2012

Interaction of the European genotype porcine reproductive and respiratory syndrome virus (PRRSV) with sialoadhesin (CD169/Siglec-1) inhibits alveolar macrophage phagocytosis

Miet De BaereHanne Van GorpPeter DelputteHans Nauwynck

A1 Journal Article in VETERINARY RESEARCH

Micro-dissecting the pathogenesis and immune response of PRRSV infection paves the way for more efficient PRRSV vaccines

Hans NauwynckHanne Van GorpMerijn VanheeUladzimir KarniychukMarc GeldhofJun CaoMieke VerbeeckWander Van Breedam

A1 Journal Article in TRANSBOUNDARY AND EMERGING DISEASES

2011

Antibody binding to porcine sialoadhesin reduces phagocytic capacity without affecting other macrophage effector functions

Miet De BaereHanne Van GorpHans NauwynckPeter Delputte

A1 Journal Article in CELLULAR IMMUNOLOGY

Better molecular insights in the pathogenesis of PRRSV infections and immune response show the way for more efficient PRRSV vaccines

Hans NauwynckWander Van BreedamHanne Van GorpUladzimir KarniychukMarc GeldhofA CaoMieke VerbeeckMerijn Vanhee

PRRSV binding to and/or internalization by its receptor sialoadhesin on macrophages is sufficient to compromise phagocytosis

Miet De BaereHanne Van GorpPeter DelputteHans Nauwynck

Porcine reproductive and respiratory syndrome virus (PRRSV) entry in its host cell, the macrophage

Hans NauwynckHanne Van GorpMieke VerbeeckIlias FrydasWander Van Breedam

Porcine sialoadhesin (CD169/Siglec-1) is an endocytic receptor that allows targeted delivery of toxins and antigens to macrophages

Peter DelputteHanne Van GorpHerman FavoreelInge HoebekeIris DelrueHannah DewerchinFrederik VerdonckBruno VerhasseltEric CoxHans Nauwynck

A1 Journal Article in PLOS ONE

2010

Identification of the CD163 protein domains involved in infection of the porcine reproductive and respiratory syndrome virus

Hanne Van GorpWander Van BreedamJan Van DoorsselaerePeter DelputteHans Nauwynck

Identification of the CD163 protein domains involved in infection of the porcine reproductive and respiratory syndrome virus

Hanne Van GorpWander Van BreedamJan Van DoorsselaerePeter DelputteHans Nauwynck

A1 Journal Article in JOURNAL OF VIROLOGY

Micro-dissecting the pathogenesis and immune response of PRRSV infection paves the way for more efficient PRRS vaccines

Hans NauwynckMerijn VanheeHanne Van GorpUladzimir KarniychukMarc GeldhofA CaoWander Van Breedam

Porcine reproductive and respiratory syndrome virus entry into the porcine macrophage

Wander Van BreedamPeter DelputteHanne Van GorpGerald MisinzoNathalie VanderheijdenXiaoBo DuanHans Nauwynck

A1 Journal Article in JOURNAL OF GENERAL VIROLOGY

Scavenger receptor CD163, a Jack-of-all-trades and potential target for cell-directed therapy

Hanne Van GorpPeter DelputteHans Nauwynck

A1 Journal Article in MOLECULAR IMMUNOLOGY

Sialoadhesin and CD163, a dynamic duo involved in porcine reproductive and respiratory syndrome virus entry in macrophages and possible targeting molecules

Hanne Van GorpHans NauwynckPeter Delputte

Susceptible cell lines for the production of porcine reproductive and respiratory syndrome virus by stable transfection of sialoadhesin and CD163

Iris DelrueHanne Van GorpJ Van DoorsselaerePeter DelputteHans Nauwynck

A1 Journal Article in BMC BIOTECHNOLOGY

The M/GP(5) glycoprotein complex of porcine reproductive and respiratory syndrome virus binds the sialoadhesin receptor in a sialic acid-dependent manner

Wander Van BreedamHanne Van GorpJiquan Q ZhangPaul R CrockerPeter DelputteHans Nauwynck

A1 Journal Article in PLOS PATHOGENS

2009

The porcine reproductive and respiratory syndrome virus requires trafficking through CD163-positive early endosomes, but not late endosomes, for productive infection

Hanne Van GorpWander Van BreedamPeter DelputteHans Nauwynck

A1 Journal Article in ARCHIVES OF VIROLOGY

2008

Sialoadhesin and CD163 join forces during entry of the porcine reproductive and respiratory syndrome virus

Hanne Van GorpWander Van BreedamPeter DelputteHans Nauwynck

A1 Journal Article in JOURNAL OF GENERAL VIROLOGY

2007

Receptor mediated porcine arterivirus entry in macrophages

Peter DelputteHanne Van GorpWander Van BreedamGerald MisinzoIris DelrueHans Nauwynck