Research Explorer

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Researcher

Hanna De Saffel

12 Results

2023

A tapt1 knock-out zebrafish line with aberrant lens development and impaired vision models human early-onset cataract

Tamara JaraysehBrecht GuillemynHanna De SaffelJan Willem BekDelfien SyxSofie SymoensYannick GansemansFilip Van NieuwerburghSujatha JagadeeshJayarekha Raja et al.

A1 Journal Article in HUMAN GENETICS

2021

Lrp5 mutant and crispant zebrafish faithfully model human osteoporosis, establishing the zebrafish as a platform for CRISPR‐based functional screening of osteoporosis candidate genes

Jan Willem BekChen ShochatAdelbert De ClercqHanna De SaffelAnnekatrien BoelJuriaan MetzFrans RodenburgDavid KarasikAndy WillaertPaul Coucke

A1 Journal Article in JOURNAL OF BONE AND MINERAL RESEARCH

Photoconvertible fluorescent proteins : a versatile tool in zebrafish skeletal imaging

Jan Willem BekAdelbert De ClercqHanna De SaffelMieke SoenensAnn HuysseunePaul WittenPaul CouckeAndy Willaert

A1 Journal Article in JOURNAL OF FISH BIOLOGY

2019

In-depth characterization of the ultrastructural variability of the vertebral column in a severe, medium and mildly affected Osteogenesis Imperfecta zebrafish model

Adelbert De ClercqHanna De SaffelJan Willem BekMyriam ClaeysPetra VermassenPaul CouckeAndy Willaert

Knock-out of atp6v1e1b in zebrafish faithfully recapitulates the human cutis laxa syndrome and highlights the endosomal pathway in disease pathogenesis

Lore PottiePatrick SipsBert CallewaertPetra VermassenHanna De SaffelPaul Coucke

Knock-out of atp6v1e1b in zebrafish faithfully recapitulates the human cutis laxa syndrome and highlights the endosomal pathway in disease pathogenesis.

Lore PottiePatrick SipsHanna De SaffelPetra VermassenPaul CouckeBert Callewaert

The zebrafish as a model for fragile bone disorders

Jan Willem BekHanna De SaffelOsama EssawiAdelbert De ClercqPaul WittenAnn HuysseuneJuriaan MetzPhil SalmonPaul CouckeAndy Willaert

The zebrafish as a model for recessive types of Osteogenesis Imperfecta.

Jan Willem BekHanna De SaffelOsama EssawiAdelbert De ClercqPaul WittenAnn HuysseunePhil SalmonPaul CouckeAndy Willaert

The zebrafish as a model for recessive types of osteogenesis imperfecta

Jan Willem BekHanna De SaffelOsama EssawiAdelbert De ClercqPaul WittenAnn HuysseunePhil SalmonPaul CouckeAndy Willaert

2018

CRISPR/Cas9-mediated homology-directed repair by ssODNs in zebrafish induces complex mutational patterns resulting from genomic integration of repair-template fragments

Annekatrien BoelHanna De SaffelWouter SteyaertBert CallewaertAnne De PaepePaul CouckeAndy Willaert

A1 Journal Article in DISEASE MODELS & MECHANISMS

Screening for osteogenic compounds using the zebrafish as a model

Jan Willem BekCharlotte GistelinckHanna De SaffelPaul CouckeAndy Willaert

Zebrafish type I collagen mutants faithfully recapitulate human type I collagenopathies

Charlotte GistelinckRonald Y KwonFransiska MalfaitSofie SymoensMatthew P HarrisKatrin HenkeMichael B HawkinsShannon FisherPatrick SipsBrecht Guillemyn et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA