Research Explorer

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Researcher

Gwen Sys

Publications & Research Data

Awards & Distinctions

86 Results

2026

Exploration of patient-derived models as a tool to support therapeutic decision making in sarcoma patients

Stefanie GijselsGabriëlle van RamshorstOlivier De WeverGwen Sys

2025

A living sarcoma biobank for translational research purposes

Stefanie GijselsMerlijn VekemanSuzanne FischerDavid CreytensAlexander AckermanAnaïs OngenaetLaurens BoiEline SegersJens De TemmermanFrancesca Casteur et al.

Correction : Kalisvaart et al. Relative wash-in rate in dynamic contrast-enhanced magnetic resonance imaging as a new prognostic biomarker for event-free survival in 82 patients with osteosarcoma : a multicenter study

Gijsbert M. KalisvaartRichard E. EvenhuisWillem GrootjansThomas Van Den BergheMartijn CallensJudith V. M. G. BovéeDavid CreytensHans GelderblomFrank M. SpeetjensLore Lapeire et al.

Evaluation of response to neoadjuvant chemotherapy in osteosarcoma using dynamic contrast-enhanced MRI : development and external validation of a predictive model

Thomas Van Den BergheGijsbert M. KalisvaartWillem GrootjansMaryse LejolyWouter HuysseJudith V.M.G. BovéeDavid CreytensHans GelderblomFrank M. SpeetjensLore Lapeire et al.

Evaluation of the value of (dynamic) contrast-enhanced MRI for the diagnosis and follow-up of central cartilage tumours

Thomas Van Den BergheMaryse LejolyFelix DelbareWouter HuysseDavid CreytensGwen SysKoenraad Verstraete

Evaluation of the value of dynamic contrast-enhanced MRI for the diagnosis and follow-up of central cartilage tumors

Maryse LejolyThomas Van Den BergheFelix DelbareWouter HuysseDavid CreytensGwen SysKoenraad Verstraete

A1 Journal Article in EUROPEAN JOURNAL OF RADIOLOGY

Exact radiological-pathological correlation of chondrosarcomas using a patient-specific 3D mold

Maryse LejolyThomas Van Den BergheDavid CreytensWouter HuysseGwen SysRenaat CoopmanKoenraad Verstraete

A1 Journal Article in SKELETAL RADIOLOGY

From biopsy to the bench and back : exploration of patient-derived tumour models and EV proteomic profiles to support therapeutic decision making for sarcoma patients

Suzanne FischerGwen SysAn HendrixLore Lapeire

Identifying consensus and areas for future research in chondrosarcoma : a report from the Birmingham Orthopaedic Oncology Meeting

Lee M. JeysGuy V. MorrisVineet J. KurisunkalEduardo BotelloRichard A. BoyleWalid EbeidMatthew T. HoudekAjay PuriPietro RuggieriBernadette Brennan et al.

A1 Journal Article in BONE & JOINT JOURNAL

Identifying novel treatments for sarcoma through relevant surgical mouse models

Stefanie GijselsSuzanne FischerLotte LegiestGabriëlle van RamshorstGwen SysOlivier De Wever

Mitochondrial DNA ddPCR as an alternative to Alu-repeats for quantifying metastatic burden in CAM assays

Shari AertsHilde De RoosterGwen SysWard De Spiegelaere

Monitoring denosumab therapy of giant cell tumours of bone using a radiological-pathological correlation

Thomas Van Den BergheMaryse LejolyWouter HuysseDavid CreytensLore LapeireGwen SysKoenraad Verstraete

Preserving potential : surgeons as key partners in establishing a living sarcoma biobank for translational research purposes

Stefanie GijselsMerlijn VekemanSuzanne FischerDavid CreytensAlexander AckermanAnaïs OngenaetLaurens BoiEline SegersJens De TemmermanFrancesca Casteur et al.

A1 Journal Article in SURGICAL ONCOLOGY-OXFORD

Relative wash-in rate on dynamic contrast-enhanced MRI as a new prognostic factor in patients with osteosarcoma after neoadjuvant chemotherapy?

Thomas Van Den BergheGijsbert M. KalisvaartRichard E. EvenhuisWillem GrootjansJudith V.M.G. BovéeDavid CreytensHans GelderblomFrank M. SpeetjensLore LapeireGwen Sys et al.

The CAM assay as a model to investigate the invasive character of canine sarcomas

Shari AertsEllis ClappaertHilde De RoosterGwen SysHilde De CockWard De Spiegelaere

2024

Biological sample collection to advance research and treatment : a fight osteosarcoma through European research and Euro Ewing Consortium statement

Darrell GreenRoelof van EwijkElisa TirteiDimosthenis AndreouFredrik BaecklundDaniel BaumhoerStefan S. BielackRajesh BotchuKjetil BoyeBernadette Brennan et al.

A1 Journal Article in CLINICAL CANCER RESEARCH

BOOM (Birmingham Orthopaedic Oncology Meeting) Consensus Statements

Thomas Van Den BergheMaryse LejolyDesirée DorleijnGwen SysKoenraad Verstraete

Can chondrosarcoma be safely diagnosed by radiology alone using radiology classifications eg. BACTIP, RAS?

Thomas Van Den BergheMaryse LejolyDesirée DorleijnGwen SysKoenraad Verstraete

Clinical consequences of the increasing complexity of intratumour heterogeneity in soft-tissue sarcoma

Stefanie GijselsSuzanne FischerDavid CreytensMerlijn VekemanAlexander AckermanLaurens BoiEline SegersRuben Van BoxstaelGwen SysGabriëlle van Ramshorst et al.

Diagnosis and monitoring denosumab therapy of giant cell tumors of bone : radiologic-pathologic correlation

Maryse LejolyThomas Van Den BergheDavid CreytensWouter HuysseLore LapeireGwen SysKoenraad Verstraete

A1 Journal Article in SKELETAL RADIOLOGY

Diagnosis and monitoring denosumab therapy of giant cell tumours of bone : radiological-pathological correlation

Thomas Van Den BergheMaryse LejolyWouter HuysseDavid CreytensLore LapeireGwen SysKoenraad Verstraete

Diagnosis and monitoring denosumab therapy of giant cell tumours of bone : radiological-pathological correlation

Thomas Van Den BergheMaryse LejolyWouter HuysseDavid CreytensLore LapeireGwen SysKoenraad Verstraete

Evaluation of response to neoadjuvant chemotherapy in osteosarcoma using dynamic contrast-enhanced MRI : development and external validation of a model

Gijsbert M. KalisvaartThomas Van Den BergheWillem GrootjansMaryse LejolyWouter HuysseJudith V. M. G. BovéeDavid CreytensHans GelderblomFrank M. SpeetjensLore Lapeire et al.

A1 Journal Article in SKELETAL RADIOLOGY

Generation of post-surgical minimal residual disease models to investigate metastasis in soft tissue sarcoma patient-derived orthotopic xenografts

Suzanne FischerDavid CreytensStefanie GijselsBenedicte DescampsLore LapeireAn HendrixGwen SysOlivier De Wever

A2 Journal Article in STAR PROTOCOLS

Identification and validation of extracellular vesicle reference genes for the normalization of RT‐qPCR data

Cláudio PinheiroNiké GuilbertLien LippensQuentin RouxRobin BoiySuzanne FischerSofie Van DorpeBram De CraeneGeert BerxTom Boterberg et al.

A1 Journal Article in JOURNAL OF EXTRACELLULAR VESICLES

Imaging advances in oncology : from diagnosis to therapy : evaluation of the value of (dynamic) contrast-enhanced MRI for the diagnosis and follow-up of central cartilaginous tumours

Thomas Van Den BergheMaryse LejolyFelix DelbareWouter HuysseDavid CreytensGwen SysKoenraad Verstraete

Navigating the complexity of intratumor heterogeneity in precision medicine

Stefanie GijselsSuzanne FischerDavid CreytensMerlijn VekemanAlexander AckermanLaurens BoiEline SegersRuben Van BoxstaelGwen SysGabriëlle van Ramshorst et al.

Pelophen B is a non-taxoid binding microtubule-stabilizing agent with promising preclinical anticancer properties

Stephanie VermeulenSam ErnstEva BlondeelZihan XiaPekka RappuJyrki HeinoSandor DedeyneHannelore DenysGwen SysStefanie Gijsels et al.

A1 Journal Article in SCIENTIFIC REPORTS

RAF1-rearranged spindle cell mesenchymal tumor with calcification and heterotopic ossification : a case report and review of literature

Fleur CordierSiebe LoontiensJoni Van der MeulenLore LapeireGabriëlle van RamshorstGwen SysJo Van DorpeDavid Creytens

A1 Journal Article in INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY

Relative wash-in rate in dynamic contrast-enhanced magnetic resonance imaging as a new prognostic biomarker for event-free survival in 82 patients with osteosarcoma : a multicenter study

Gijsbert M. KalisvaartRichard E. EvenhuisWillem GrootjansThomas Van Den BergheMartijn CallensJudith V. M. G. BovéeDavid CreytensHans GelderblomFrank M. SpeetjensLore Lapeire et al.

A1 Journal Article in CANCERS

Single tumour, many faces - unraveling intratumour complexity in soft-tissue sarcoma

Stefanie GijselsSuzanne FischerDavid CreytensMerlijn VekemanAlexander AckermanLaurens BoiEline SegersRuben Van BoxstaelGwen SysOlivier De Wever et al.

Single tumour, many faces : unraveling intratumour complexity of soft tissue sarcoma

Stefanie GijselsSuzanne FischerDavid CreytensMerlijn VekemanAlexander AckermanLaurens BoiEline SegersRuben Van BoxstaelGabriëlle van RamshorstGwen Sys et al.

Single tumour, many faces : unraveling intratumour complexity of soft-tissue sarcoma

Stefanie GijselsSuzanne FischerDavid CreytensMerlijn VekemanGabriëlle van RamshorstGwen SysOlivier De Wever

Which imaging feature gives the best positive/negative predictive value for differentiating an enchondroma from an ACT/chondrosarcoma?

Thomas Van Den BergheMaryse LejolyDesirée DorleijnGwen SysKoenraad Verstraete

2023

Development of a live tissue sarcoma biobank to support the creation of patient-derived translational models

Merlijn VekemanAlexander AckermanAnaïs OngenaetSuzanne FischerStefanie GijselsOlivier De WeverAn HendrixDavid CreytensGwen Sys

Ex vivo sarcoma cell cultures from paired primary, local relapse and metastatic sites reveals phenotypic heterogeneity

Stefanie GijselsSuzanne FischerLaurens BoiEline SegersGwen SysGabriëlle van RamshorstOlivier De Wever

Oncological and functional outcomes after high or total sacrectomy : a systematic review

Nathalie BraeckmanEva KerckhoveGwen SysGabriëlle van RamshorstJesse Demuytere

Orthotopic xenografts of paired sarcoma primary tumour, local relapse and metastatic sites reveals phenotypic heterogeneity in a minimal residual disease model

Stefanie GijselsSuzanne FischerDavid CreytensMerlijn VekemanAlexander AckermanGwen SysGabriëlle van RamshorstOlivier De Wever

Playing the infinite in sarcoma care and research

Editorial material

Post‐operative minimal residual disease models to study metastatic relapse in soft‐tissue sarcoma patient‐derived xenografts

Suzanne FischerDavid CreytensSofie De GeyterElly De VliegherePiet PattynSarah-Lee BekaertKaat DurinckNadine Van RoyAn HendrixLore Lapeire et al.

A1 Journal Article in CLINICAL AND TRANSLATIONAL MEDICINE

2022

Diagnosis of epithelioid hemangioendothelioma 8 days postpartum : is there a link with pregnancy? : A case report and review of the literature

Nicky SomersDavid CreytensSimon Van BelleGwen SysLore Lapeire

A1 Journal Article in ACTA CLINICA BELGICA

Maligne wekedelentumoren

Gwen SysDavid Creytens

Metastasized orthotopic patient-derived xenografts as preclinical model to guide therapeutic decision making in soft tissue sarcoma patients

Suzanne FischerElly De VlieghereDavid CreytensOlivier De WeverAn HendrixLore LapeireGwen Sys

Undifferentiated sarcoma of bone with a round to epithelioid cell phenotype harboring a novel EWSR1-SSX2 fusion identified by RNA-based next-generation sequencing

Fleur CordierJoni Van der MeulenBram Van GaeverLore LapeireGwen SysJo Van DorpeDavid Creytens

A1 Journal Article in GENES CHROMOSOMES & CANCER

2021

A challenging case of a poorly differentiated small cell variant of synovial sarcoma with unusual immunophenotype

Fleur CordierLore LapeireGwen SysJo Van DorpeDavid Creytens

A1 Journal Article in PATHOLOGY

An undifferentiated sarcoma of bone with a round to epithelioid cell phenotype harboring a novel EWSR1-SSX2 fusion identified by RNA-based next-generation sequencing

Fleur CordierJoni Van der MeulenBram Van GaeverLore LapeireGwen SysJo Van DorpeDavid Creytens

Late lung metastasis in a patient with a clear cell chondrosarcoma : an indication for a life-long follow-up?

Paulien WestCeline JacobsMicky SaerensDavid CreytensGwen SysLore Lapeire

A2 Journal Article in CASE REPORTS IN ONCOLOGICAL MEDICINE

MISpheroID : a knowledgebase and transparency tool for minimum information in spheroid identity

Arne PeirsmanEva BlondeelTasdiq AhmedJasper AnckaertDominique AudenaertTom BoterbergKrisztina BuzasNeil CarragherGastone CastellaniFlávia Castro et al.

A1 Journal Article in NATURE METHODS

NGS-analysis to the rescue : dual checkpoint inhibition in metastatic osteosarcoma : a case report and review of the literature

Laure NuytemansGwen SysDavid CreytensLore Lapeire

A1 Journal Article in ACTA CLINICA BELGICA

Patient-derived cell lines and xenografts from sarcoma patients as models for therapeutic decision making

Suzanne FischerDavid CreytensGwen SysLore LapeireAn HendrixOlivier De Wever

Spindle cell/sclerosing rhabdomyosarcoma with a novel YAP1-MAML2 fusion in a 1-year-old : not all strongly TRK-expressing spindle cell sarcomas in infants are infantile fibrosarcomas!

Fleur CordierEline AmelootCatharina DhoogeLore LapeireGwen SysJo Van DorpeDavid Creytens

A1 Journal Article in PATHOLOGY

2020

Enhancing rotational placement of reconstruction prostheses of the distal femur after sarcoma resection

Arne De SmetDries VerrewaereGwen Sys

A1 Journal Article in MEDICAL ENGINEERING & PHYSICS

Expandable distal femur megaprosthesis : a European Musculoskeletal Oncology Society study on 299 cases

Eric Lodewijk StaalsAndrea SambriDomenico Andrea CampanacciFrancesco MuratoriAndreas LeithnerMagdalena Maria GilgYair GortzakMichiel Van De SandeEdwin DierselhuisEric Mascard et al.

A1 Journal Article in JOURNAL OF SURGICAL ONCOLOGY

Surgical outcome and oncological survival of osteofibrous dysplasia-like and classic adamantinomas : an international multicenter study of 318 cases

E. M. SchutgensP. PicciD. BaumhoerR. PollockJ. V. M. G. BoveeP. C. W. HogendoornP. D. S. DijkstraA. J. Rueten-BuddeP. C. JutteF. Traub et al.

A1 Journal Article in JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

2019

Establishment of 6 novel patient-derived sarcoma cell lines and 1 patient-derived carcinosarcoma cell line

Suzanne FischerDavid CreytensLore LapeireAn HendrixPiet PattynGwen Sys

Spindle cell haemangioma of the foot

Mats Van den broeckeKoenraad VerstraeteDavid CreytensGwen Sys

2018

Aggressive giant cell tumour of the metacarpal

Lucas VerniersAdelard De BackerWim VanhoveGwen SysFilip Vanhoenacker

Een wekedelentumor als oorzaak van heuppijn

Matthias DullaertDavid CreytensWouter HuysseAdelheid SteyaertGwen Sys

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Establishment of novel patient-derived sarcoma cell lines : preliminary results

Suzanne FischerDavid CreytensLore LapeireGwen Sys

2017

Accuracy assessment of surgical planning and three-dimensional-printed patient-specific guides for orthopaedic osteotomies

Gwen SysHannelore EykensGerlinde LenaertsFelix ShumelinskyCedric RobbrechtBart Poffyn

A1 Journal Article in PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE

2016

Proximal humerus tumors

Gwen SysAlexander Van TongelLieven De Wilde

Bookchapter in Reverse shoulder arthroplasty : biomechanics, clinical techniques, and current technologies

2015

Long-term follow-up of the anterior lumbar interbody fusion procedure

Dimitri VerbruggenThomas TampereDirk UyttendaeleGwen SysBart Poffyn

A1 Journal Article in ACTA ORTHOPAEDICA BELGICA

Radiologic evaluation of compressive osseointegration for the fixation of reconstruction prostheses after tumor resection

Manol LazarovTHOMAS DE BOBart PoffynGwen Sys

A1 Journal Article in BIOMED RESEARCH INTERNATIONAL

2014

Gene expression profiling of giant cell tumor of bone reveals downregulation of extracellular matrix components decorin and lumican associated with lung metastasis

Marusya LieveldERIK BODSONG De BoeckBOUCHRA NOUMANAM Cleton-JansenE KorschingMS BenassiP PicciGwen SysBart Poffyn et al.

A1 Journal Article in VIRCHOWS ARCHIV

2013

Dynamic contrast-enhanced MR imaging for differentiation between enchondroma and chondrosarcoma

Tineke De ConinckLennart JansGwen SysWouter HuysseTom VerstraetenRamses ForsythBart PoffynKoenraad Verstraete

A1 Journal Article in EUROPEAN RADIOLOGY

The in ovo CAM-assay as a xenograft model for sarcoma

Gwen SysLore LapeireNikita StevensHerman FavoreelRamses ForsythMarc BrackeOlivier De Wever

A1 Journal Article in JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

Treatment of giant cell tumours of the distal radius with an osteoarticular allograft : report of two cases and review of the literature

Nadine HollevoetGwen SysWim Vanhove

Vacuolar H+ ATPase expression and activity is required for Rab27B dependent invasive growth and metastasis of breast cancer

An HendrixRaija SormunenWendy WestbroekKathleen LambeinHannelore DenysGwen SysGeert BraemsRudy Van den BroeckeVeronique CocquytChristian Gespach et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

2012

Are stand-alone cages sufficient for anterior lumbar interbody fusion?

Ji-dong ZhangBart PoffynGwen SysDirk Uyttendaele

A2 Journal Article in ORTHOPAEDIC SURGERY

Een veertienjarige jongen met een pijnlijke knie

Tineke De ConinckBert GeertsCatharina DhoogeGwen SysKoenraad Verstraete

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Tumor grafts derived from sarcoma patients retain tumor morphology, viability, and invasion potential and indicate disease outcomes in the chick chorioallantoic membrane model

Gwen SysMieke Van BockstalRamses ForsythMaurice BalkeBart PoffynDirk UyttendaeleMarc BrackeOlivier De Wever

A1 Journal Article in CANCER LETTERS

2011

Comparison of vertebroplasty and kyphoplasty for complications

JD ZhangBart PoffynGwen SysDirk Uyttendaele

A2 Journal Article in ORTHOPAEDIC SURGERY

Complications of bone tumors after multimodal therapy

Lorraine ShapeeroBart PoffynPieter De VisschereGwen SysDirk UyttendaeleDaniel VanelRamses ForsythKoenraad Verstraete

A1 Journal Article in EUROPEAN JOURNAL OF RADIOLOGY

Extracorporeally irradiated autografts for the treatment of bone tumours: tips and tricks

Bart PoffynGwen SysAlexander MulliezGEORGES VAN MAELELuc Van HoorebekeRamses ForsythDirk Uyttendaele

A1 Journal Article in INTERNATIONAL ORTHOPAEDICS

Giant cell tumour of bone: the extracellular matrix integrity plays a critical role in its biology and clinical behaviour

MCS LieveldAM Cleton-JansenE KorshingMS BenassiP PicciGwen SysBart PoffynNA AthanasouPCW HogendoornRamses Forsyth

2010

Extracorporeally irradiated autografts: pitfalls, tips and tricks

PIET VAN DAMMEGwen SysBart PoffynDirk Uyttendaele

Les cages ALIF isolées: suffisent-elles pour obtenir une fusion ?

Bart PoffynGwen SysKonstantijn Vander DoncktKoen HendrixTHIERRY PARLEVLIETZhang JidongDirk Uyttendaele

A2 Journal Article in Le rachis

Radiographic analysis of extracorporeally irradiated autografts

Bart PoffynGwen SysGEORGES VAN MAELELuc Van HoorebekeRamses ForsythKoenraad VerstraeteDirk Uyttendaele

A1 Journal Article in SKELETAL RADIOLOGY

2009

Follow-up of sarcoma by ultrasound

Gwen SysMartine De MuynckBart PoffynDirk UyttendaeleGuy Vanderstraeten

Post-treatment complications of soft tissue tumours

L ShapeeroPieter De VisschereKoenraad VerstraeteBart PoffynRamses ForsythGwen SysDirk Uyttendaele

A1 Journal Article in EUROPEAN JOURNAL OF RADIOLOGY

2008

OSTEOSARCOMA WITH EXTENSIVE CALCIFIED PLEURAL METASTASES AT DIAGNOSIS

NATACHA VERBEKEKoenraad VerstraeteGwen SysRamses ForsythD. KluyskensHannelore DenysDirk UyttendaeleSylvie Rottey

A1 Journal Article in Acta Clinica Belgica

2007

Charité III artificial disc replacement: Indications, preoperative examinations, and contraindications

BART POFFYNGwen SysDirk Uyttendaele

Bookchapter in Nonfusion Technologies in Spine Surgery

Reconstruction with irradiated autografts

2004

A young man found dead at work: a difficult differential diagnosis

Gwen SysMichel PietteD Van Varenbergh

A2 Journal Article in JOURNAL DE MEDECINE LEGALE DROIT MEDICAL

About the variability of the shape of the glenoid cavity

Lieven De WildeBart M BerghsEmmanuel AudenaertGwen SysGEORGES VAN MAELEErik Barbaix

A1 Journal Article in SURGICAL AND RADIOLOGIC ANATOMY

2003

The reversed Delta shoulder prosthesis in reconstruction of the proximal humerus after tumour resection

Lieven De WildeGwen SysYann JulienEdwin van OvostBart PoffynPierre Trouilloud

A2 Journal Article in ACTA ORTHOPAEDICA BELGICA