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Researcher
Gwen Sys
Profile
Projects
Publications
Activities
Awards & Distinctions
78
Results
2025
A living sarcoma biobank for translational research purposes
Stefanie Gijsels
Merlijn Vekeman
Suzanne Fischer
David Creytens
Alexander Ackerman
Anaïs Ongenaet
Laurens Boi
Eline Segers
Jens De Temmerman
Francesca Casteur
et al.
C3
Conference
2025
Evaluation of the value of dynamic contrast-enhanced MRI for the diagnosis and follow-up of central cartilage tumors
Maryse Lejoly
Thomas Van Den Berghe
Felix Delbare
Wouter Huysse
David Creytens
Gwen Sys
Koenraad Verstraete
A1
Journal Article
in
EUROPEAN JOURNAL OF RADIOLOGY
2025
Exact radiological-pathological correlation of chondrosarcomas using a patient-specific 3D mold
Maryse Lejoly
Thomas Van Den Berghe
David Creytens
Wouter Huysse
Gwen Sys
Renaat Coopman
Koenraad Verstraete
A1
Journal Article
in
SKELETAL RADIOLOGY
2025
From biopsy to the bench and back : exploration of patient-derived tumour models and EV proteomic profiles to support therapeutic decision making for sarcoma patients
Suzanne Fischer
Gwen Sys
An Hendrix
Lore Lapeire
Dissertation
2025
Identifying consensus and areas for future research in chondrosarcoma : a report from the Birmingham Orthopaedic Oncology Meeting
Lee M. Jeys
Guy V. Morris
Vineet J. Kurisunkal
Eduardo Botello
Richard A. Boyle
Walid Ebeid
Matthew T. Houdek
Ajay Puri
Pietro Ruggieri
Bernadette Brennan
et al.
A1
Journal Article
in
BONE & JOINT JOURNAL
2025
Identifying novel treatments for sarcoma through relevant surgical mouse models
Stefanie Gijsels
Suzanne Fischer
Lotte Legiest
Gabriëlle van Ramshorst
Gwen Sys
Olivier De Wever
C3
Conference
2025
Preserving potential : surgeons as key partners in establishing a living sarcoma biobank for translational research purposes
Stefanie Gijsels
Merlijn Vekeman
Suzanne Fischer
David Creytens
Alexander Ackerman
Anaïs Ongenaet
Laurens Boi
Eline Segers
Jens De Temmerman
Francesca Casteur
et al.
A1
Journal Article
in
SURGICAL ONCOLOGY-OXFORD
2025
2024
BOOM (Birmingham Orthopaedic Oncology Meeting) Consensus Statements
Thomas Van Den Berghe
Maryse Lejoly
Desirée Dorleijn
Gwen Sys
Koenraad Verstraete
U
Conference
2024
Biological sample collection to advance research and treatment : a fight osteosarcoma through European research and Euro Ewing Consortium statement
Darrell Green
Roelof van Ewijk
Elisa Tirtei
Dimosthenis Andreou
Fredrik Baecklund
Daniel Baumhoer
Stefan S. Bielack
Rajesh Botchu
Kjetil Boye
Bernadette Brennan
et al.
A1
Journal Article
in
CLINICAL CANCER RESEARCH
2024
Can chondrosarcoma be safely diagnosed by radiology alone using radiology classifications eg. BACTIP, RAS?
Thomas Van Den Berghe
Maryse Lejoly
Desirée Dorleijn
Gwen Sys
Koenraad Verstraete
C3
Conference
2024
Clinical consequences of the increasing complexity of intratumour heterogeneity in soft-tissue sarcoma
Stefanie Gijsels
Suzanne Fischer
David Creytens
Merlijn Vekeman
Alexander Ackerman
Laurens Boi
Eline Segers
Ruben Van Boxstael
Gwen Sys
Gabriëlle van Ramshorst
et al.
C3
Conference
2024
Diagnosis and monitoring denosumab therapy of giant cell tumors of bone : radiologic-pathologic correlation
Maryse Lejoly
Thomas Van Den Berghe
David Creytens
Wouter Huysse
Lore Lapeire
Gwen Sys
Koenraad Verstraete
A1
Journal Article
in
SKELETAL RADIOLOGY
2024
Diagnosis and monitoring denosumab therapy of giant cell tumours of bone : radiological-pathological correlation
Thomas Van Den Berghe
Maryse Lejoly
Wouter Huysse
David Creytens
Lore Lapeire
Gwen Sys
Koenraad Verstraete
C3
Conference
2024
Diagnosis and monitoring denosumab therapy of giant cell tumours of bone : radiological-pathological correlation
Thomas Van Den Berghe
Maryse Lejoly
Wouter Huysse
David Creytens
Lore Lapeire
Gwen Sys
Koenraad Verstraete
C3
Conference
2024
Evaluation of response to neoadjuvant chemotherapy in osteosarcoma using dynamic contrast-enhanced MRI : development and external validation of a model
Gijsbert M. Kalisvaart
Thomas Van Den Berghe
Willem Grootjans
Maryse Lejoly
Wouter Huysse
Judith V. M. G. Bovée
David Creytens
Hans Gelderblom
Frank M. Speetjens
Lore Lapeire
et al.
A1
Journal Article
in
SKELETAL RADIOLOGY
2024
Generation of post-surgical minimal residual disease models to investigate metastasis in soft tissue sarcoma patient-derived orthotopic xenografts
Suzanne Fischer
David Creytens
Stefanie Gijsels
Benedicte Descamps
Lore Lapeire
An Hendrix
Gwen Sys
Olivier De Wever
A2
Journal Article
in
STAR PROTOCOLS
2024
Identification and validation of extracellular vesicle reference genes for the normalization of RT‐qPCR data
Cláudio Pinheiro
Niké Guilbert
Lien Lippens
Quentin Roux
Robin Boiy
Suzanne Fischer
Sofie Van Dorpe
Bram De Craene
Geert Berx
Tom Boterberg
et al.
A1
Journal Article
in
JOURNAL OF EXTRACELLULAR VESICLES
2024
Imaging advances in oncology : from diagnosis to therapy : evaluation of the value of (dynamic) contrast-enhanced MRI for the diagnosis and follow-up of central cartilaginous tumours
Thomas Van Den Berghe
Maryse Lejoly
Felix Delbare
Wouter Huysse
David Creytens
Gwen Sys
Koenraad Verstraete
C3
Conference
2024
Navigating the complexity of intratumor heterogeneity in precision medicine
Stefanie Gijsels
Suzanne Fischer
David Creytens
Merlijn Vekeman
Alexander Ackerman
Laurens Boi
Eline Segers
Ruben Van Boxstael
Gwen Sys
Gabriëlle van Ramshorst
et al.
C3
Conference
2024
Pelophen B is a non-taxoid binding microtubule-stabilizing agent with promising preclinical anticancer properties
Stephanie Vermeulen
Sam Ernst
Eva Blondeel
Zihan Xia
Pekka Rappu
Jyrki Heino
Sandor Dedeyne
Hannelore Denys
Gwen Sys
Stefanie Gijsels
et al.
A1
Journal Article
in
SCIENTIFIC REPORTS
2024
RAF1-rearranged spindle cell mesenchymal tumor with calcification and heterotopic ossification : a case report and review of literature
Fleur Cordier
Siebe Loontiens
Joni Van der Meulen
Lore Lapeire
Gabriëlle van Ramshorst
Gwen Sys
Jo Van Dorpe
David Creytens
A1
Journal Article
in
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
2024
Relative wash-in rate in dynamic contrast-enhanced magnetic resonance imaging as a new prognostic biomarker for event-free survival in 82 patients with osteosarcoma : a multicenter study
Gijsbert M. Kalisvaart
Richard E. Evenhuis
Willem Grootjans
Thomas Van Den Berghe
Martijn Callens
Judith V. M. G. Bovée
David Creytens
Hans Gelderblom
Frank M. Speetjens
Lore Lapeire
et al.
A1
Journal Article
in
CANCERS
2024
Single tumour, many faces - unraveling intratumour complexity in soft-tissue sarcoma
Stefanie Gijsels
Suzanne Fischer
David Creytens
Merlijn Vekeman
Alexander Ackerman
Laurens Boi
Eline Segers
Ruben Van Boxstael
Gwen Sys
Olivier De Wever
et al.
C3
Conference
2024
Single tumour, many faces : unraveling intratumour complexity of soft tissue sarcoma
Stefanie Gijsels
Suzanne Fischer
David Creytens
Merlijn Vekeman
Alexander Ackerman
Laurens Boi
Eline Segers
Ruben Van Boxstael
Gabriëlle van Ramshorst
Gwen Sys
et al.
C3
Conference
2024
Single tumour, many faces : unraveling intratumour complexity of soft-tissue sarcoma
Stefanie Gijsels
Suzanne Fischer
David Creytens
Merlijn Vekeman
Gabriëlle van Ramshorst
Gwen Sys
Olivier De Wever
C3
Conference
2024
Which imaging feature gives the best positive/negative predictive value for differentiating an enchondroma from an ACT/chondrosarcoma?
Thomas Van Den Berghe
Maryse Lejoly
Desirée Dorleijn
Gwen Sys
Koenraad Verstraete
C3
Conference
2024
2023
Development of a live tissue sarcoma biobank to support the creation of patient-derived translational models
Merlijn Vekeman
Alexander Ackerman
Anaïs Ongenaet
Suzanne Fischer
Stefanie Gijsels
Olivier De Wever
An Hendrix
David Creytens
Gwen Sys
C3
Conference
2023
Ex vivo sarcoma cell cultures from paired primary, local relapse and metastatic sites reveals phenotypic heterogeneity
Stefanie Gijsels
Suzanne Fischer
Laurens Boi
Eline Segers
Gwen Sys
Gabriëlle van Ramshorst
Olivier De Wever
C3
Conference
2023
Oncological and functional outcomes after high or total sacrectomy : a systematic review
Nathalie Braeckman
Eva Kerckhove
Gwen Sys
Gabriëlle van Ramshorst
Jesse Demuytere
C3
Conference
2023
Orthotopic xenografts of paired sarcoma primary tumour, local relapse and metastatic sites reveals phenotypic heterogeneity in a minimal residual disease model
Stefanie Gijsels
Suzanne Fischer
David Creytens
Merlijn Vekeman
Alexander Ackerman
Gwen Sys
Gabriëlle van Ramshorst
Olivier De Wever
C3
Conference
2023
Playing the infinite in sarcoma care and research
Gwen Sys
Editorial material
2023
Post‐operative minimal residual disease models to study metastatic relapse in soft‐tissue sarcoma patient‐derived xenografts
Suzanne Fischer
David Creytens
Sofie De Geyter
Elly De Vlieghere
Piet Pattyn
Sarah-Lee Bekaert
Kaat Durinck
Nadine Van Roy
An Hendrix
Lore Lapeire
et al.
A1
Journal Article
in
CLINICAL AND TRANSLATIONAL MEDICINE
2023
2022
Diagnosis of epithelioid hemangioendothelioma 8 days postpartum : is there a link with pregnancy? : A case report and review of the literature
Nicky Somers
David Creytens
Simon Van Belle
Gwen Sys
Lore Lapeire
A1
Journal Article
in
ACTA CLINICA BELGICA
2022
Maligne wekedelentumoren
Gwen Sys
David Creytens
C3
Conference
2022
Metastasized orthotopic patient-derived xenografts as preclinical model to guide therapeutic decision making in soft tissue sarcoma patients
Suzanne Fischer
Elly De Vlieghere
David Creytens
Olivier De Wever
An Hendrix
Lore Lapeire
Gwen Sys
C3
Conference
2022
Undifferentiated sarcoma of bone with a round to epithelioid cell phenotype harboring a novel EWSR1-SSX2 fusion identified by RNA-based next-generation sequencing
Fleur Cordier
Joni Van der Meulen
Bram Van Gaever
Lore Lapeire
Gwen Sys
Jo Van Dorpe
David Creytens
A1
Journal Article
in
GENES CHROMOSOMES & CANCER
2022
2021
A challenging case of a poorly differentiated small cell variant of synovial sarcoma with unusual immunophenotype
Fleur Cordier
Lore Lapeire
Gwen Sys
Jo Van Dorpe
David Creytens
A1
Journal Article
in
PATHOLOGY
2021
An undifferentiated sarcoma of bone with a round to epithelioid cell phenotype harboring a novel EWSR1-SSX2 fusion identified by RNA-based next-generation sequencing
Fleur Cordier
Joni Van der Meulen
Bram Van Gaever
Lore Lapeire
Gwen Sys
Jo Van Dorpe
David Creytens
C3
Conference
2021
Late lung metastasis in a patient with a clear cell chondrosarcoma : an indication for a life-long follow-up?
Paulien West
Celine Jacobs
Micky Saerens
David Creytens
Gwen Sys
Lore Lapeire
A2
Journal Article
in
CASE REPORTS IN ONCOLOGICAL MEDICINE
2021
MISpheroID : a knowledgebase and transparency tool for minimum information in spheroid identity
Arne Peirsman
Eva Blondeel
Tasdiq Ahmed
Jasper Anckaert
Dominique Audenaert
Tom Boterberg
Krisztina Buzas
Neil Carragher
Gastone Castellani
Flávia Castro
et al.
A1
Journal Article
in
NATURE METHODS
2021
NGS-analysis to the rescue : dual checkpoint inhibition in metastatic osteosarcoma : a case report and review of the literature
Laure Nuytemans
Gwen Sys
David Creytens
Lore Lapeire
A1
Journal Article
in
ACTA CLINICA BELGICA
2021
Patient-derived cell lines and xenografts from sarcoma patients as models for therapeutic decision making
Suzanne Fischer
David Creytens
Gwen Sys
Lore Lapeire
An Hendrix
Olivier De Wever
C3
Conference
2021
Spindle cell/sclerosing rhabdomyosarcoma with a novel YAP1-MAML2 fusion in a 1-year-old : not all strongly TRK-expressing spindle cell sarcomas in infants are infantile fibrosarcomas!
Fleur Cordier
Eline Ameloot
Catharina Dhooge
Lore Lapeire
Gwen Sys
Jo Van Dorpe
David Creytens
A1
Journal Article
in
PATHOLOGY
2021
2020
Enhancing rotational placement of reconstruction prostheses of the distal femur after sarcoma resection
Arne De Smet
Dries Verrewaere
Gwen Sys
A1
Journal Article
in
MEDICAL ENGINEERING & PHYSICS
2020
Expandable distal femur megaprosthesis : a European Musculoskeletal Oncology Society study on 299 cases
Eric Lodewijk Staals
Andrea Sambri
Domenico Andrea Campanacci
Francesco Muratori
Andreas Leithner
Magdalena Maria Gilg
Yair Gortzak
Michiel Van De Sande
Edwin Dierselhuis
Eric Mascard
et al.
A1
Journal Article
in
JOURNAL OF SURGICAL ONCOLOGY
2020
Surgical outcome and oncological survival of osteofibrous dysplasia-like and classic adamantinomas : an international multicenter study of 318 cases
E. M. Schutgens
P. Picci
D. Baumhoer
R. Pollock
J. V. M. G. Bovee
P. C. W. Hogendoorn
P. D. S. Dijkstra
A. J. Rueten-Budde
P. C. Jutte
F. Traub
et al.
A1
Journal Article
in
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
2020
2019
Establishment of 6 novel patient-derived sarcoma cell lines and 1 patient-derived carcinosarcoma cell line
Suzanne Fischer
David Creytens
Lore Lapeire
An Hendrix
Piet Pattyn
Gwen Sys
C3
Conference
2019
Spindle cell haemangioma of the foot
Mats Van den broecke
Koenraad Verstraete
David Creytens
Gwen Sys
Other
2019
2018
Aggressive giant cell tumour of the metacarpal
Lucas Verniers
Adelard De Backer
Wim Vanhove
Gwen Sys
Filip Vanhoenacker
Other
2018
Een wekedelentumor als oorzaak van heuppijn
Matthias Dullaert
David Creytens
Wouter Huysse
Adelheid Steyaert
Gwen Sys
A2
Journal Article
in
TIJDSCHRIFT VOOR GENEESKUNDE
2018
Establishment of novel patient-derived sarcoma cell lines : preliminary results
Suzanne Fischer
David Creytens
Lore Lapeire
Gwen Sys
C3
Conference
2018
2017
Accuracy assessment of surgical planning and three-dimensional-printed patient-specific guides for orthopaedic osteotomies
Gwen Sys
Hannelore Eykens
Gerlinde Lenaerts
Felix Shumelinsky
Cedric Robbrecht
Bart Poffyn
A1
Journal Article
in
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE
2017
2016
Proximal humerus tumors
Gwen Sys
Alexander Van Tongel
Lieven De Wilde
Bookchapter
in
Reverse shoulder arthroplasty : biomechanics, clinical techniques, and current technologies
2016
2015
Long-term follow-up of the anterior lumbar interbody fusion procedure
Dimitri Verbruggen
Thomas Tampere
Dirk Uyttendaele
Gwen Sys
Bart Poffyn
A1
Journal Article
in
ACTA ORTHOPAEDICA BELGICA
2015
Radiologic evaluation of compressive osseointegration for the fixation of reconstruction prostheses after tumor resection
Manol Lazarov
THOMAS DE BO
Bart Poffyn
Gwen Sys
A1
Journal Article
in
BIOMED RESEARCH INTERNATIONAL
2015
2014
Gene expression profiling of giant cell tumor of bone reveals downregulation of extracellular matrix components decorin and lumican associated with lung metastasis
Marusya Lieveld
ERIK BODSON
G De Boeck
BOUCHRA NOUMAN
AM Cleton-Jansen
E Korsching
MS Benassi
P Picci
Gwen Sys
Bart Poffyn
et al.
A1
Journal Article
in
VIRCHOWS ARCHIV
2014
2013
Dynamic contrast-enhanced MR imaging for differentiation between enchondroma and chondrosarcoma
Tineke De Coninck
Lennart Jans
Gwen Sys
Wouter Huysse
Tom Verstraeten
Ramses Forsyth
Bart Poffyn
Koenraad Verstraete
A1
Journal Article
in
EUROPEAN RADIOLOGY
2013
The in ovo CAM-assay as a xenograft model for sarcoma
Gwen Sys
Lore Lapeire
Nikita Stevens
Herman Favoreel
Ramses Forsyth
Marc Bracke
Olivier De Wever
A1
Journal Article
in
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
2013
Treatment of giant cell tumours of the distal radius with an osteoarticular allograft : report of two cases and review of the literature
Nadine Hollevoet
Gwen Sys
Wim Vanhove
C3
Conference
2013
Vacuolar H+ ATPase expression and activity is required for Rab27B dependent invasive growth and metastasis of breast cancer
An Hendrix
Raija Sormunen
Wendy Westbroek
Kathleen Lambein
Hannelore Denys
Gwen Sys
Geert Braems
Rudy Van den Broecke
Veronique Cocquyt
Christian Gespach
et al.
A1
Journal Article
in
INTERNATIONAL JOURNAL OF CANCER
2013
2012
Are stand-alone cages sufficient for anterior lumbar interbody fusion?
Ji-dong Zhang
Bart Poffyn
Gwen Sys
Dirk Uyttendaele
A2
Journal Article
in
ORTHOPAEDIC SURGERY
2012
Een veertienjarige jongen met een pijnlijke knie
Tineke De Coninck
Bert Geerts
Catharina Dhooge
Gwen Sys
Koenraad Verstraete
A2
Journal Article
in
TIJDSCHRIFT VOOR GENEESKUNDE
2012
Tumor grafts derived from sarcoma patients retain tumor morphology, viability, and invasion potential and indicate disease outcomes in the chick chorioallantoic membrane model
Gwen Sys
Mieke Van Bockstal
Ramses Forsyth
Maurice Balke
Bart Poffyn
Dirk Uyttendaele
Marc Bracke
Olivier De Wever
A1
Journal Article
in
CANCER LETTERS
2012
2011
Comparison of vertebroplasty and kyphoplasty for complications
JD Zhang
Bart Poffyn
Gwen Sys
Dirk Uyttendaele
A2
Journal Article
in
ORTHOPAEDIC SURGERY
2011
Complications of bone tumors after multimodal therapy
Lorraine Shapeero
Bart Poffyn
Pieter De Visschere
Gwen Sys
Dirk Uyttendaele
Daniel Vanel
Ramses Forsyth
Koenraad Verstraete
A1
Journal Article
in
EUROPEAN JOURNAL OF RADIOLOGY
2011
Extracorporeally irradiated autografts for the treatment of bone tumours: tips and tricks
Bart Poffyn
Gwen Sys
Alexander Mulliez
GEORGES VAN MAELE
Luc Van Hoorebeke
Ramses Forsyth
Dirk Uyttendaele
A1
Journal Article
in
INTERNATIONAL ORTHOPAEDICS
2011
Giant cell tumour of bone: the extracellular matrix integrity plays a critical role in its biology and clinical behaviour
MCS Lieveld
AM Cleton-Jansen
E Korshing
MS Benassi
P Picci
Gwen Sys
Bart Poffyn
NA Athanasou
PCW Hogendoorn
Ramses Forsyth
C3
Conference
2011
2010
Extracorporeally irradiated autografts: pitfalls, tips and tricks
PIET VAN DAMME
Gwen Sys
Bart Poffyn
Dirk Uyttendaele
C3
Conference
2010
Les cages ALIF isolées: suffisent-elles pour obtenir une fusion ?
Bart Poffyn
Gwen Sys
Konstantijn Vander Donckt
Koen Hendrix
THIERRY PARLEVLIET
Zhang Jidong
Dirk Uyttendaele
A2
Journal Article
in
Le rachis
2010
Radiographic analysis of extracorporeally irradiated autografts
Bart Poffyn
Gwen Sys
GEORGES VAN MAELE
Luc Van Hoorebeke
Ramses Forsyth
Koenraad Verstraete
Dirk Uyttendaele
A1
Journal Article
in
SKELETAL RADIOLOGY
2010
2009
Follow-up of sarcoma by ultrasound
Gwen Sys
Martine De Muynck
Bart Poffyn
Dirk Uyttendaele
Guy Vanderstraeten
C3
Conference
2009
Post-treatment complications of soft tissue tumours
L Shapeero
Pieter De Visschere
Koenraad Verstraete
Bart Poffyn
Ramses Forsyth
Gwen Sys
Dirk Uyttendaele
A1
Journal Article
in
EUROPEAN JOURNAL OF RADIOLOGY
2009
2008
OSTEOSARCOMA WITH EXTENSIVE CALCIFIED PLEURAL METASTASES AT DIAGNOSIS
NATACHA VERBEKE
Koenraad Verstraete
Gwen Sys
Ramses Forsyth
D. Kluyskens
Hannelore Denys
Dirk Uyttendaele
Sylvie Rottey
A1
Journal Article
in
Acta Clinica Belgica
2008
2007
Charité III artificial disc replacement: Indications, preoperative examinations, and contraindications
BART POFFYN
Gwen Sys
Dirk Uyttendaele
Bookchapter
in
Nonfusion Technologies in Spine Surgery
2007
Reconstruction with irradiated autografts
Gwen Sys
C3
Conference
2007
2004
A young man found dead at work: a difficult differential diagnosis
Gwen Sys
Michel Piette
D Van Varenbergh
A2
Journal Article
in
JOURNAL DE MEDECINE LEGALE DROIT MEDICAL
2004
About the variability of the shape of the glenoid cavity
Lieven De Wilde
Bart M Berghs
Emmanuel Audenaert
Gwen Sys
GEORGES VAN MAELE
Erik Barbaix
A1
Journal Article
in
SURGICAL AND RADIOLOGIC ANATOMY
2004
2003
The reversed Delta shoulder prosthesis in reconstruction of the proximal humerus after tumour resection
Lieven De Wilde
Gwen Sys
Yann Julien
Edwin van Ovost
Bart Poffyn
Pierre Trouilloud
A2
Journal Article
in
ACTA ORTHOPAEDICA BELGICA
2003