Research Explorer

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Researcher

Guy Brusselle

Publications & Research Data

Awards & Distinctions

585 Results

2025

Anti-IL-5 treatment, but not neutrophil interference, attenuates inflammation in a mixed granulocytic asthma mouse model, elicited by air pollution

Joyceline De VolderAnnelies BontinckValerie HaeltermanLouis BoonGuy JoosGuy BrusselleTania Maes

A1 Journal Article in RESPIRATORY RESEARCH

Asthma in the biologics era : should oral corticosteroid therapy be relegated to history?

Florence SchleichJohn J. OppenheimerGuy BrusselleLiam G. HeaneyWilliam W. BusseNjira L. LugogoNicola A. HananiaMatteo BoniniMarek LommatzschPascal Chanez et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE

Augmenting clinical trials in asthma through digital technology, decentralised designs, and person-centric endpoints : opportunities and challenges

Job F M van BovenRichard W CostelloKit C B RoesGuy BrusselleKjeld HansenJerry A KrishnanChristopher E BrightlingNicolas RocheSalman SiddiquiBruce J Kirenga et al.

A1 Journal Article in LANCET RESPIRATORY MEDICINE

Biologics and airway remodeling in asthma : early, late, and potential preventive effects

G. VarricchiR. PotoM. LommatzschGuy BrusselleF. BraidoJ. C. VirchowG. W. Canonica

A1 Journal Article in ALLERGY

Biologics in severe asthma : unmasking EGPA along the way

Virginie Van HeckSebastian RiemannGuy Brusselle

Editorial material

Cardiovascular safety of biologic therapies in patients with severe asthma : a nationwide cohort study in Belgium

Frauke Van VaerenberghDelphine VauterinMaxim GrymonprezLowie VanfleterenGuy BrusselleLies Lahousse

A1 Journal Article in LANCET REGIONAL HEALTH-EUROPE

Chronic cough and chronic pruritus in older adults : a population-based cross-sectional study

Juliette BollemeijerSebastian RiemannHok Bing ThioTamar E.C. NijstenGuy BrusselleLuba M. Pardo

A1 Journal Article in ERJ OPEN RESEARCH

Complementary role of fractional exhaled nitric oxide and blood eosinophil counts in asthma prevalence and diagnosis : sex-specific evidence from NHANES

Sebastian RiemannAndrei MalinovschiGuy Brusselle

Consensus from European experts on severe eosinophilic asthma and chronic rhinosinusitis with nasal polyps : results from the OverSEA Delphi study

Claus BachertGuy BrusselleJosé Antonio Castillo VizueteIgnacio DávilaMartin LaudienVeronica SecciaPeter Schmid-GrendelmeierAlessandra VultaggioKonstantina KallinikouLaura Walrave et al.

A2 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY : GLOBAL

Diagnosis of asthma in adults

Sebastian RiemannAndrei MalinovschiPaul O'ByrneGuy Brusselle

Bookchapter in ERS monograph : asthma

Dupilumab induces long-term on-treatment clinical remission in patients with type 2 asthma

Ian D. PavordKlaus F. RabeElliot IsraelStanley J. SzeflerGuy BrusselleNami Pandit-AbidArman AltincatalZhen ChenNikhil AminAsif H. Khan et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE

Eosinophils in asthma phenotypes : perpetrators or guilty by association?

Marek LommatzschRoland BuhlKarl-Christian BergmannGuy BrusselleG Walter CanonicaDavid J JacksonLiam G HeaneyParameswaran NairJ Christian Virchow

A1 Journal Article in LANCET RESPIRATORY MEDICINE

Genetic and environmental risk factors for asthma : towards prevention

Gerard KoppelmanMaria Pino-YanesErik MelénPippa PowellKen BrackeJuan CeledonGuy Brusselle

A1 Journal Article in LANCET RESPIRATORY MEDICINE

Impact of respiratory and cardiovascular drug exposure on lung function trajectories

Xander BertelsDelphine VauterinSebastian RiemannFrauke Van VaerenberghKristiaan ProesmansAndré G. UitterlindenM. Arfan IkramGuy BrusselleBruno H. StrickerLies Lahousse

A1 Journal Article in ANNALS OF THE AMERICAN THORACIC SOCIETY

Inflammatory and clinical risk factors for asthma attacks (ORACLE2) : a patient-level meta-analysis of control groups of 22 randomised trials

Fleur L. MeulmeesterSamuel Mailhot-LaroucheCarlos Celis-PreciadoSamuel Lemaire-PaquetteSanjay RamakrishnanMichael E. WechslerGuy BrusselleJonathan CorrenJo HardySarah E. Diver et al.

A1 Journal Article in LANCET RESPIRATORY MEDICINE

Oral corticosteroid reduction and discontinuation in adults with corticosteroid-dependent, severe, uncontrolled asthma treated with tezepelumab (WAYFINDER) : a multicentre, single-arm, phase 3b trial

David J JacksonNjira L LugogoMark GurnellLiam G HeaneyStephanie KornGuy BrussellePascal ChanezRicardo del OlmoJean-Pierre LlanosNanna Keeling et al.

A1 Journal Article in LANCET RESPIRATORY MEDICINE

Preserved ratio impaired spirometry (PRISm) : prognostic, preventable and treatable?

Guy BrusselleSebastian Riemann

Editorial material

Prevention of cardiovascular and other systemic adverse outcomes in patients with asthma treated with biologics

Mohsen SadatsafaviTrung N. TranGhislaine SceloMing-Ju TsaiJohn BusbyBenjamin EmmanuelLiam G. HeaneyChristine JenkinsFlavia HoyteGiorgio Walter Canonica et al.

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Prospective REALITI-A study : 2-year real-world benefits of mepolizumab in severe asthma

Cristiano CarusoG. Walter CanonicaManish PatelAndrew SmithMark C. LiuRafael Alfonso-CristanchoRobert G. PriceRupert W. JakesLydia DemetriouAntonio Valero et al.

A2 Journal Article in CHEST PULMONARY

Relapse of eosinophilic granulomatosis with polyangiitis (EGPA) despite maintenance treatment with low-dose mepolizumab

Aurelie VanthuyneSebastian RiemannGuy Brusselle

A2 Journal Article in RESPIROLOGY CASE REPORTS

Relapse of eosinophilic granulomatosis with polyangiitis (EGPA) despite maintenance treatment with low‐dose mepolizumab

Aurelie VanthuyneSebastian RiemannGuy Brusselle

A2 Journal Article in RESPIROLOGY CASE REPORTS

Response to biologics along a gradient of T2 involvement in patients with severe asthma : a data-driven biomarker clustering approach

Eileen WangWilliam HenleyDésirée Larenas-LinnemannLakmini BulathsinhalaTrung N. TranMichael E. WechslerShawn D. AaronMona Al-AhmadRiyad Al-LehebiAlan Altraja et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE

Roads to remission : evolving treatment concepts in type 2 inflammatory diseases

Marek LommatzschKatharina BlumchenLisa A. BeckJean BousquetGuy BrusselleWytske J. FokkensEckard HamelmannSusanne LauHagen OttOliver Pfaar et al.

A1 Journal Article in ECLINICALMEDICINE

Sex differences in clinical risk factors and type-2 biomarkers for predicting asthma attacks in the ORACLE2 patient-level meta-analysis

Sebastian RiemannFleur MeulmeesterSamuel Mailhot-LaroucheSanjay RamakrishnanMichael E WechslerJonathan CorrenSarah E DiverChristopher E BrightlingMario CastroNicola A Hanania et al.

Trajectories of chronic cough in older adults and their associations with airway diseases

Sebastian RiemannYiannis De MeersmanArfan M. IkramGuy Brusselle

Type‐2 biomarkers, asthma diagnosis and lung function impairment in the general population

Sebastian RiemannAndrei MalinovschiGuy Brusselle

A1 Journal Article in CLINICAL AND EXPERIMENTAL ALLERGY

Unraveling inflammatory responses in pollutant-aggravated allergic asthma

Joyceline De VolderTania MaesGuy Brusselle

2024

Aanbevelingen voor de behandeling van astma bij volwassenen in de eerstelijnsgezondheidszorg

Sebastian RiemannGuy Brusselle

A4 Journal Article in MEDI-SFEER

All-cause mortality of Staging of Airflow Obstruction by Ratio-categorized patients with Chronic Obstructive Pulmonary Disease among the general population

Xander BertelsSebastian RiemannDelphine VauterinLies LahousseGuy Brusselle

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Anti-inflammatoire reliever (AIR) als eerstekeuzebehandeling bij mild astma : nieuwe aanbevelingen op basis van de 2023 ERS Task Force ICS/formoterol in mild astma

Sebastian RiemannGuy Brusselle

A4 Journal Article in BLOEDVATEN, HART, LONGEN

Baseline characteristics and ICS/LAMA/LABA response in asthma : analyses from the CAPTAIN study

Louis -Philippe BouletCarl AbbottGuy BrusselleDawn EdwardsJohn OppenheimerIan D. PavordEmilio PizzichiniHironori SagaraDavid SladeMichael E. Wechsler et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE

Case report : dual monoclonal antibody therapy in chronic rhinosinusitis with nasal polyps and severe eosinophilic asthma : a proteome analysis

Manon BlauwblommePhilippe GevaertSharon Van NevelSebastian RiemannElke VandewalleGabriële HoltappelsNatalie De RuyckLara DeryckeAnne-Sophie EeckelsStijn Vanhee et al.

A2 Journal Article in FRONTIERS IN ALLERGY

Clinical course of suspected familial and sporadic idiopathic pulmonary fibrosis : data from the PROOF-Next registry

Antoine FroidureBenjamin BondueCaroline DahlqvistJulien GuiotNatacha GusbinGil WirtzGuy BrusselleDanielle StrensHans SlabbynckWim A. Wuyts

A1 Journal Article in RESPIROLOGY

Clinical relevance of lung function trajectory clusters in middle-aged and older adults

Xander BertelsJames C. RossRosa FanerMichael H. ChoM. Arfan IkramGuy BrusselleLies Lahousse

A1 Journal Article in ERJ OPEN RESEARCH

Evaluating β2-agonists as siRNA delivery adjuvants for pulmonary surfactant-coated nanogel inhalation therapy

Pieterjan MerckxGRIET CONICKXEvy BlommeTania MaesKen BrackeGuy BrusselleStefaan De SmedtKoen Raemdonck

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Exploring the genetics of airflow limitation in lung function across the lifespan : a polygenic risk score study

Natalia Hernandez-PachecoAnna KilanowskiAshish KumarJohn A. CurtinNúria OlveraSara KressXander BertelsLies LahousseLaxmi BhattaRaquel Granell et al.

A1 Journal Article in ECLINICALMEDICINE

Flemish network on rare connective tissue diseases (CTD) : patient pathways in systemic sclerosis : first steps taken

Yves PietteFreek Van den BosscheJ. AertsN. AertsS. AjeganovaV. BadotN. BerghenD. BlockmansGuy BrusselleN. Caeyers et al.

A1 Journal Article in ACTA CLINICA BELGICA

Genome-wide association study of preserved ratio impaired spirometry (PRISm)

Daniel H. HigbeeAlvin LirioFergus HamiltonRaquel GranellAnnah B. WyssStephanie J. LondonTraci M. BartzSina A. GharibMichael H. ChoEmily Wan et al.

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Impact of exogenous sex steroids in asthma : interim results of the ENIGI-lung study

Sebastian RiemannJeroen VervalckeGuy T'SjoenGuy Brusselle

Need for sex-stratified reference values for exhaled nitric oxide as biomarker in chronic cough

Sebastian RiemannJohnmary Tochukwu ArinzeAndrei MalinovschiGuy Brusselle

A1 Journal Article in ERJ OPEN RESEARCH

Phenotyping of severe asthma in the era of broad-acting anti-asthma biologics

A BourdinGuy BrusselleS CouillardML FajtLG HeaneyE IsraelPJ McDowellA Menzies-GowN MartinPD Mitchell et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE

Respiratory epidemiology in the advancement of precision medicine

Xander BertelsLies LahousseGuy Brusselle

Revisiting the clinical interpretation of CT-measured pulmonary artery-to-aorta ratio : the Rotterdam study

C. F. KhanM. Kamran IkramNatalie TerzikhanGuy BrusselleDaniel Bos

A1 Journal Article in ACADEMIC RADIOLOGY

Run-in periods and treatment outcomes in asthma trials : a narrative review

Emilio PizzichiniGuy BrusselleDawn EdwardsPeter G. GibsonHuib A. KerstjensAlison MooreDavid SladeRobert A. WiseShiyuan Zhang

A2 Journal Article in CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS

Selective replacement of cholesterol with cationic amphiphilic drugs enables the design of lipid nanoparticles with improved RNA delivery

Bram BogaertAliona DebisschopThomas EhouarneHannelore Van EeckhoutteJoyceline De VolderAn JacobsEline PottieRiet De RyckeAurélie CrabbéPieter Mestdagh et al.

A1 Journal Article in NANO LETTERS

The AGE-RAGE axis associates with chronic pulmonary diseases and smoking in the Rotterdam study

Tianqi LuLies LahousseSara WijnantJinluan ChenGuy BrusselleMandy van HoekM. Carola Zillikens

A1 Journal Article in RESPIRATORY RESEARCH

The protective role of testosterone and its precursors in asthma and asthma-related symptoms : cross-sectional findings from the Rotterdam Study

Sebastian RiemannLayal ChakerGuy Brusselle

The role of circulating sex hormones in mild-to-moderate asthma : cross-sectional analysis within the Rotterdam Study

Sebastian RiemannLayal ChakerGuy Brusselle

2023

Advanced glycation end products (AGEs) in relation to COPD and lung function : the Rotterdam Study

Tianqi LuLies LahousseSara WijnantJinluan ChenGuy BrusselleMandy Van HoekM. Carola Zillikens

Association of a polygenic risk score for chronic obstructive pulmonary disease with lung function across the lifespan

Natalia Hernandez-PachecoAnna KilanowskiAshish KumarJohn A. CurtinNuria OlveraSara KressXander BertelsLies LahousseLaxmi BhattaRaquel Granell et al.

Collaboration between explainable artificial intelligence and pulmonologists improves the accuracy of pulmonary function test interpretation

Nilakash DasSofie HappaertsIwein GyselinckMichael StaesEric DeromGuy BrusselleFelip BurgosMarco ContoliAnh Tuan Dinh-XuanFrits M. E. Franssen et al.

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Development and validation of an electronic daily control score for asthma (e-DASTHMA) : a real-world direct patient data study

Bernardo Sousa-PintoCristina JacomeAna Margarida PereiraFrederico S. RegateiroRute AlmeidaWienczyslawa CzarlewskiMarek KulusMohamed H. ShamjiLouis-Philippe BouletMatteo Bonini et al.

A1 Journal Article in LANCET DIGITAL HEALTH

Development of core outcome measures sets for paediatric and adult Severe Asthma (COMSA)

Ekaterina KhalevaAnna RattuChris BrightlingAndrew BushApostolos BossiosArnaud BourdinKian Fan ChungRekha ChaudhuriCourtney ColemanSven-Erik Dahlen et al.

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Dupilumab efficacy in patients with uncontrolled or oral corticosteroid-dependent allergic and nonallergic asthma

Guy BrusselleSantiago QuirceAlberto PapiPiotr KunaBradley E. ChippsNicola A. HananiaMichael BlaissJerome MsihidJuby A. Jacob-NaraYamo Deniz et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE

Effect of stepping up to high-dose inhaled corticosteroids in patients with asthma : UK database study

Ian D Pavord FMedSciTrung N TranRupert C JonesJavier NuevoMaarten van den BergeGuy BrusselleAndrew N Menzies-GowDerek SkinnerVictoria CarterJanwillem W H Kocks et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE

Frailty transitions in older persons with lung function impairment : a population-based study

Sara WijnantElizabeth BenzAnnemarie I LuikFernando RivadeneiraTrudy VoortmanGuy BrusselleLies Lahousse

A1 Journal Article in JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Global access and patient safety in the transition to environmentally friendly respiratory inhalers : the Global Initiative for Asthma perspective

Mark L LevyEric D BatemanKeith AllanLeonard B BacharierMatteo BoniniLouis-Philippe BouletArnaud BourdinChris BrightlingGuy BrusselleRoland Buhl et al.

Editorial material

Is efficacy of tezepelumab independent of severe asthma phenotype?

Guy BrusselleSebastian Riemann

Editorial material

Long-term efficacy of dupilumab in severe asthma by baseline oral corticosteroid dose

Christian DomingoKlaus F RabeDavid PriceGuy BrusselleMichael E. WechslerChangming XiaNami Pandit-AbidRebecca GallPaul J. RoweYamo Deniz et al.

A1 Journal Article in ERJ OPEN RESEARCH

Mepolizumab attenuates ILC2s proliferation and activity in adults with severe eosinophilic asthma

Guy BrusselleSebastian RiemannTania Maes

Editorial material

Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk

Nick ShrineAbril G. IzquierdoJing ChenRichard PackerRobert J. HallAnna L. GuyattChiara BatiniRebecca J. ThompsonChandan PavuluriVidhi Malik et al.

A1 Journal Article in NATURE GENETICS

Novel genetic variants associated with inhaled corticosteroid treatment response in older adults with asthma

Alberta L. WangLies LahousseAmber DahlinAhmed Edris MohamedMichael McGeachieSharon M. LutzJoanne E. SordilloGuy BrusselleJessica Lasky-SuScott T. Weiss et al.

A1 Journal Article in THORAX

Oral corticosteroid use and sarcopenia-related traits in older people with chronic airway disease : a population-based study

Elizabeth BenzLies LahousseJohnmary Tochukwu ArinzeSara WijnantMaria de RidderFernando RivadeneiraGuy BrusselleBruno H. Stricker

A1 Journal Article in ERJ OPEN RESEARCH

Parasitic infections related to anti-type 2 immunity monoclonal antibodies : a disproportionality analysis in the food and drug administration’s adverse event reporting system (FAERS)

Victor PeraGuy BrusselleSebastian RiemannJan A. KorsErik M. Van MulligenRowan ParryMarcel de WildePeter R. RijnbeekKatia Verhamme

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

Phenotyping asthma with airflow obstruction in middle-aged and older adults : a CADSET clinical research collaboration

Xander BertelsAhmed Edris MohamedJudith Garcia-AymerichRosa FanerHowraman MeteranTorben SigsgaardPeter AlterClaus VogelmeierNuria OlveraNazanin Zounemat Kermani et al.

A1 Journal Article in BMJ OPEN RESPIRATORY RESEARCH

Remission outcomes in severe eosinophilic asthma with mepolizumab therapy : analysis of the REDES study

Ian PavordFrances GardinerLiam G. HeaneyChristian DomingoRobert G. PriceAlison PullanJohn OppenheimerGuy BrusselleHiroyuki NagaseGeoffrey Chupp et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Reply to Lipworth and Chan

Sebastian RiemannGuy Brusselle

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

RIPK1 kinase-dependent inflammation and cell death contribute to the pathogenesis of COPD

Hannelore Van EeckhoutteChantal DonovanRichard Y. KimThomas M. ConlonMeshal AnsariHaroon KhanRanjith JayaramanNicole G. HansbroYves DondelingerTom Delanghe et al.

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Risk stratifying interstitial lung abnormalities to guide early diagnosis interstitial lung diseases

Marlies S WijsenbeekGuy Brusselle

Editorial material

Role of low-dose mepolizumab maintenance therapy in preventing flare-ups in ANCA+ EGPA : a case-report

Sebastian RiemannAurelie VanthuyneGuy Brusselle

Safety and effectiveness of as-needed formoterol in asthma patients taking inhaled corticosteroid (ICS)-formoterol or ICS-salmeterol maintenance therapy

Helen Kathryn ReddelGuy BrusselleRosa LamarcaPer GustafsonGary P AndersonCarin Jorup

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE

Smoking-related dysregulation of plasma circulating microRNAs : the Rotterdam study

Irma KarabegovicSilvana C. E. MaasYu ShuaiM. Arfan IkramBruno StrickerJoachim AertsGuy BrusselleLies LahousseTrudy VoortmanMohsen Ghanbari

A1 Journal Article in HUMAN GENOMICS

The role of regulated cell death in chronic obstructive pulmonary disease (COPD)

Hannelore Van EeckhoutteKen BrackeGuy BrusselleTom Vanden Berghe

Trajectory of neutrophilic responses in a mouse model of pollutant-aggravated allergic asthma

Joyceline De VolderAnnelies BontinckKatrien De GroveIris DirvenValerie HaeltermanGuy JoosGuy BrusselleTania Maes

A1 Journal Article in ENVIRONMENTAL POLLUTION

Trends in outpatient azithromycin prescribing in respiratory diseases

Victor PeraHelen PanenMaria A. J. De RidderLies LahousseGuy BrussellePeter R. RijnbeekKatia Verhamme

2022

Anti–interleukin-5 therapy is associated with attenuated lung function decline in severe eosinophilic asthma patients from the Belgian Severe Asthma Registry

Sophie GraffGuy BrusselleShane HanonCarine SohyLieven DupontRudy PecheAlain MichilsCharles PiletteGuy JoosLies Lahousse et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE

Associations of pulmonary function with MRI brain volumes : a coordinated multi-study analysis

Stefan FrenzelJoshua C. BisElias F. GudmundssonAdrienne O'DonnellJeannette SiminoAmber YaqubTraci M. BartzGuy BrusselleRobin BuelowCharles S. DeCarlil et al.

A1 Journal Article in JOURNAL OF ALZHEIMERS DISEASE

B cells and their crosstalk with fibroblasts in chronic obstructive pulmonary disease (COPD) : translational research during the COVID-19 pandemic

Merel JacobsKen BrackeGuy Brusselle

Biologic therapies for severe asthma

Guy BrusselleGerard H. Koppelman

A1 Journal Article in NEW ENGLAND JOURNAL OF MEDICINE

Changes in lung function in European adults born between 1884 and 1996 and implications for the diagnosis of lung disease : a cross-sectional analysis of ten population-based studies

James P AllinsonShoaib AfzalYunus ÇolakDebbie JarvisHelena BackmanMaarten van den BergeH Marike BoezenMarie-Kathrin BreyerRobab Breyer-KohansalGuy Brusselle et al.

A1 Journal Article in LANCET RESPIRATORY MEDICINE

Characterization of asthma by age of onset : a multi-database cohort study

Esme J BaanEmmely de RoosMarjolein EngelkesMaria de RidderLars PedersenKlara BerencsiDani Prieto-AlhambraFrancesco LapiMelissa K Van DykePeter Rijnbeek et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE

Classification of COPD : fostering prevention and precision medicine in the Lancet Commission on COPD

Guy BrusselleMarc Humbert

Editorial material

Disease-modifying anti-asthmatic drugs

Marek LommatzschGuy BrusselleG. Walter CanonicaDavid J. JacksonParameswaran NairRoland BuhlJohann Christian Virchow

Editorial material

Epidemiology of interstitial lung diseases and their progressive-fibrosing behaviour in six European countries

Ole HilbergAnna-Maria Hoffmann-VoldVanessa SmithDemosthenes BourosMaritta KilpeläinenJulien GuiotAntonio MoraisSusana ClementeZoe DaniilDespina Papakosta et al.

A1 Journal Article in ERJ OPEN RESEARCH

ERS statement : a core outcome set for clinical trials evaluating the management of chronic obstructive pulmonary disease (COPD) exacerbations

Alexander G. MathioudakisFekri AbrougAlvar AgustiSachin AnanthPer BakkeKonstantinos BartziokasBianca BegheAndras BikovThomas BradburyGuy Brusselle et al.

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Genetic associations and architecture of asthma-chronic obstructive pulmonary disease overlap

Catherine JohnAnna L. GuyattNick ShrineRichard PackerThorunn A. OlafsdottirJiangyuan LiuLystra P. HaydenSu H. ChuJukka T. KoskelaJian’an Luan et al.

A1 Journal Article in CHEST

Global Initiative for Asthma Strategy 2021 : executive summary and rationale for key changes

Helen K. ReddelLeonard B. BacharierEric D. BatemanChristopher E. BrightlingGuy BrusselleRoland BuhlAlvaro A. CruzLiesbeth DuijtsJeffrey M. DrazenJ. Mark FitzGerald et al.

A1 Journal Article in RESPIROLOGY

Global Initiative for Asthma Strategy 2021 : executive summary and rationale for key changes

Helen K. ReddelLeonard B. BacharierEric D. BatemanChristopher E. BrightlingGuy BrusselleRoland BuhlAlvaro A. CruzLiesbeth DuijtsJeffrey M. DrazenJ. Mark FitzGerald et al.

A1 Journal Article in ARCHIVOS DE BRONCONEUMOLOGIA

Global Initiative for Asthma Strategy 2021 : executive summary and rationale for key changes

Helen K. ReddelLeonard B. BacharierEric D. BatemanChristopher E. BrightlingGuy BrusselleRoland BuhlAlvaro A. CruzLiesbeth DuijtsJeffrey M. DrazenJ. Mark FitzGerald et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE

Global initiative for Asthma Strategy 2021 : executive summary and rationale for key changes

Helen K. ReddelLeonard B. BacharierEric D. BatemanChristopher E. BrightlingGuy BrusselleRoland BuhlAlvaro A. CruzLiesbeth DuijtsJeffrey M. DrazenJ. Mark FitzGerald et al.

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Global Initiative for Asthma Strategy 2021 : executive summary and rationale for key changes

Helen K. ReddelLeonard B. BacharierEric D. BatemanChristopher E. BrightlingGuy BrusselleRoland BuhlAlvaro A. CruzLiesbeth DuijtsJeffrey M. DrazenJ. Mark FitzGerald et al.

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

IL-10 producing regulatory B cells are decreased in blood from smokers and COPD patients

Merel JacobsSven VerschraegenBihiyga SalhiJasper AnckaertPieter MestdaghGuy BrusselleKen Bracke

A1 Journal Article in RESPIRATORY RESEARCH

Lung function impairment in relation to cognition and vascular brain lesions : the Rotterdam Study

Tian XiaoSara WijnantIsabelle van der VelpenNatalie TerzikhanLies LahousseM. Kamran IkramMeike W VernooijGuy BrusselleM. Arfan Ikram

A1 Journal Article in JOURNAL OF NEUROLOGY

Multi-ancestry genome-wide association study of asthma exacerbations

Esther Herrera-LuisVictor E. OrtegaElizabeth J. AmplefordYang Yie SioRaquel GranellEmmely de RoosNatalie TerzikhanErnesto Elorduy VergaraNatalia Hernandez-PachecoJavier Perez-Garcia et al.

A1 Journal Article in PEDIATRIC ALLERGY AND IMMUNOLOGY

NO in de uitgeademde lucht, een overzicht

H. VannesteEric DeromGuy BrusselleGuy Joos

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Non-typeable Haemophilus influenzae–Moraxella catarrhalis vaccine for the prevention of exacerbations in chronic obstructive pulmonary disease : a multicentre, randomised, placebo-controlled, observer-blinded, proof-of-concept, phase 2b trial

Guy BrusselleTom M A Wilkinson

A1 Journal Article in LANCET RESPIRATORY MEDICINE

Pharmacogenetics of inhaled corticosteroids and exacerbation risk in adults with asthma

Ahmed Edris MohamedEmmely de RoosMichael J. McGeachieKatia VerhammeGuy BrusselleKelan G. TantisiraCarlos IribarrenMeng LuAnn Chen WuBruno H. Stricker et al.

A1 Journal Article in CLINICAL AND EXPERIMENTAL ALLERGY

Pulmonary function and blood DNA methylation a multiancestry epigenome-wide association meta-analysis

Mikyeong LeeTianxiao HuanDaniel L. McCartneyGeetha ChittoorMaaike de VriesLies LahousseJennifer N. NguyenJennifer A. BrodyJuan Castillo-FernandezNatalie Terzikhan et al.

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pulmonary hypertension in interstitial lung disease : an area of unmet clinical need

Sebastiaan DhontBert ZwaenepoelEls VandecasteeleGuy BrusselleMichel De Pauw

A1 Journal Article in ERJ OPEN RESEARCH

Real-life effectiveness of mepolizumab in severe asthma : a systematic literature review

Elliot IsraelGiorgio Walter CanonicaGuy BrusselleShibing YangPeter H. HowarthAmber L. MartinMaria KoufopoulouSteven G. SmithRafael Alfonso-Cristancho

A1 Journal Article in JOURNAL OF ASTHMA

Sarcopenia, systemic immune-inflammation index and all-cause mortality in middle-aged and older people with COPD and asthma : a population-based study

Elizabeth BenzSara WijnantKaterina TrajanoskaJohnmary Tochukwu ArinzeEmmely de RoosMaria de RidderRoss WilliamsFrank van RooijKatia M. C. VerhammeM. Arfan Ikram et al.

A1 Journal Article in ERJ OPEN RESEARCH

Serum immunoglobulins, pneumonia risk, and lung function in middle-aged and older individuals : a population-based cohort study

Samer R. KhanAnna VanoverscheldeLies LahousseRobin P. PeetersP. Martin van HagenGuy BrusselleLayal ChakerVirgil A. S. H. Dalm

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

The interrelationship of chronic cough and depression : a prospective population-based study

Johnmary Tochukwu ArinzeAmy HofmanEmmely de RoosMaria A. J. de RidderKatia VerhammeBruno StrickerGuy BrusselleAnnemarie Luik

A1 Journal Article in ERJ OPEN RESEARCH

The low flyers : persistent airflow limitation in young adults

Francesca PolverinoGeorge R. WashkoRonina A. CovarEric B. HysingerTillie L. HackettSurya P. BhattGuy BrusselleShyamali C. Dharmage

Editorial material

Validation of clinical COPD phenotypes for prognosis of long-term mortality in Swedish and Dutch cohorts

S. GagatekSara WijnantB. StallbergK. LisspersGuy BrusselleX. ZhouM. HasselgrenS. MontgomeryiJ. SundhjC. Janson et al.

A1 Journal Article in COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

2021

3TR : a pan-European cross-disease research consortium aimed at improving personalised biological treatment of asthma and COPD

Celeste PorsbjergAnke H. Maitland-van der ZeeGuy BrusselleGiorgio Walter CanonicaAlvar AgustiRosa FanerClaus F. VogelmeierMartijn NawijnMaarten van den BergeFranca Rusconi et al.

Editorial material

A microRNA-21–mediated SATB1/S100A9/NF-κB axis promotes chronic obstructive pulmonary disease pathogenesis

Richard Y. KimKrishna P. SunkaraKen R. BrackeAndrew G. JarnickiChantal DonovanAlan C. HsuAntonio IeniEmma L. BeckettIzabela GalvãoSara Wijnant et al.

A1 Journal Article in SCIENCE TRANSLATIONAL MEDICINE

A systematic analysis of protein-altering exonic variants in chronic obstructive pulmonary disease

Matthew MollVictoria E. JacksonBing YuMegan L. GroveStephanie J. LondonSina A. GharibTraci M. BartzColleen M. SitlaniJosee DupuisGeorge T. O'Connor et al.

A1 Journal Article in AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

ARIA digital anamorphosis : digital transformation of health and care in airway diseases from research to practice

Jean BousquetJosep M. AntoClaus BachertTari HaahtelaTorsten ZuberbierWienczyslawa CzarlewskiAnna BedbrookSinthia Bosnic-AnticevichG. Walter CanonicaVictoria Cardona et al.

A1 Journal Article in ALLERGY

Beclometasone dipropionate/formoterol maintenance and reliever therapy asthma exacerbation benefit increases with blood eosinophil level

Guy BrusselleGabriele NicoliniLuigi SantoroDaniele GuastallaAlberto Papi

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Cluster analysis of inflammatory biomarker expression in the international severe asthma registry

Eve DentonDavid B. PriceTrung N. TranG. Walter CanonicaAndrew Menzies-GowJ. Mark FitzGeraldMohsen SadatsafaviLuis Perez de LlanoGeorge ChristoffAnna Quinton et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE

Cluster analysis of inflammatory biomarker expression in the International Severe Asthma Registry (ISAR)

E. DentonD. PriceT. TranG. CanonicaA. Menzies-GowJ. FitzgeraldM. SadatsafaviL. Prerez De LlanoG. ChristoffA. Quinton et al.

Comparison of cerebral blood flow in subjects with and without chronic obstructive pulmonary disease from the population-based Rotterdam Study

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A1 Journal Article in BMJ OPEN

Effect of ACE1 polymorphism rs1799752 on protein levels of ACE2, the SARS-CoV-2 entry receptor, in alveolar lung epithelium

Merel JacobsLies LahousseHannelore Van EeckhoutteSara WijnantJoris DelangheGuy BrusselleKen Bracke

A1 Journal Article in ERJ OPEN RESEARCH

Effect of beta-blockers on the risk of COPD exacerbations according to indication of use : the Rotterdam Study

Leila KarimiLies LahoussePhebe De NockerBruno H. StrickerGuy BrusselleKatia Verhamme

A1 Journal Article in ERJ OPEN RESEARCH

Efficacy and safety of once-daily single-inhaler triple therapy (FF/UMEC/VI) versus FF/VI in patients with inadequately controlled asthma (CAPTAIN) : a double-blind, randomised, phase 3A trial

Laurie A LeeZelie BailesNeil BarnesLouis-Philippe BouletDawn EdwardsAndrew FowlerNicola A HananiaHuib A M KerstjensEdward KerwinRobert Nathan et al.

A1 Journal Article in LANCET RESPIRATORY MEDICINE

Eosinophilic and noneosinophilic asthma : an expert consensus framework to characterize phenotypes in a global real-life severe asthma cohort

Liam G. HeaneyLuis Perez de LlanoMona Al-AhmadVibeke BackerJohn BusbyGiorgio Walter CanonicaGeorge C. ChristoffBorja G. CosioJ. Mark FitzGeraldEnrico Heffler et al.

A1 Journal Article in CHEST

Epigenome-wide association study on diffusing capacity of the lung

Natalie TerzikhanHanfei XuAhmed Edris MohamedKen BrackeFien VerhammeBruno H. C. StrickerJosée DupuisLies LahousseGeorge T. O'ConnorGuy Brusselle

A1 Journal Article in ERJ OPEN RESEARCH

Incidence and predictors of asthma exacerbations in middleaged and older adults : the Rotterdam Study

Emmely de RoosLies LahousseKatia VerhammeGert-Jan BraunstahlJohannes J. C. C. M. in 't VeenBruno H. StrickerGuy Brusselle

A1 Journal Article in ERJ OPEN RESEARCH

Incidence, prevalence and long-term progression of Goh algorithm rated interstitial lung disease in systemic sclerosis in two independent cohorts in flanders : a retrospective cohort study

Els VandecasteeleKarin MelsensAmber VanhaeckeDaniel BlockmansCarolien BonroyCharlotte CartonEllen DeschepperFilip De KeyserFrederic HoussiauYves Piette et al.

A1 Journal Article in SEMINARS IN ARTHRITIS AND RHEUMATISM

Lung function impairment and the risk of incident dementia : the Rotterdam study

Tian XiaoSara WijnantSilvan LicherNatalie TerzikhanLies LahousseM. Kamran IkramGuy BrusselleM. Arfan Ikram

A1 Journal Article in JOURNAL OF ALZHEIMERS DISEASE

Mepolizumab for chronic rhinosinusitis with nasal polyps

Guy BrussellePhilippe Gevaert

Editorial material

MiR-223 is increased in lungs of patients with COPD and modulates cigarette smoke-induced pulmonary inflammation

Mirjam RoffelTania MaesCorry-Anke BrandsmaMaarten van den BergeBart M. VanaudenaerdeGuy JoosGuy BrusselleIrene H. HeijinkKen Bracke

A1 Journal Article in AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Necroptosis signalling promotes inflammation, airway remodelling and emphysema in COPD

Zhe LuHannelore Van EeckhoutteGang LiuPrema M NairBernadette JonesCaitlin GillisB. Christina NalkurthiFien VerhammeTamariche Buyle-HuybrechtPeter Vandenabeele et al.

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Patient characteristics, biomarkers, and exacerbation risk in severe, uncontrolled asthma

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A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

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Quantification and role of innate lymphoid cell subsets in Chronic Obstructive Pulmonary Disease

Evy BlommeSharen ProvoostElise De SmetKatrien De GroveHannelore Van EeckhoutteJoyceline De VolderPhilip M HansbroMatteo BonatoMarina SaettaSara Wijnant et al.

A1 Journal Article in CLINICAL & TRANSLATIONAL IMMUNOLOGY

Rare and low-frequency exonic variants and gene-by-smoking interactions in pulmonary function

Tianzhong YangVictoria E. JacksonV Smith, AlbertHan ChenTraci M. BartzColleen M. SitlaniBruce M. PsatySina A. GharibGeorge T. O'ConnorJosee Dupuis et al.

A1 Journal Article in SCIENTIFIC REPORTS

Sarcopenia in older people with chronic airway diseases : the Rotterdam study

Elizabeth BenzKaterina TrajanoskaJosje D. SchoufourLies LahousseEmmely de RoosNatalie TerzikhanCarolina Medina-GomezKatia VerhammeRoss WilliamsBruno H. Stricker et al.

A1 Journal Article in ERJ OPEN RESEARCH

The ALPACA study : (in)appropriate LAMA prescribing in asthma : a cohort analysis

E. J. BaanC. E. HoeveM. De RidderL. DemoenLies LahousseGuy BrusselleKatia Verhamme

A1 Journal Article in PULMONARY PHARMACOLOGY & THERAPEUTICS

The interrelatedness of chronic cough and chronic pain

Johnmary Tochukwu ArinzeKatia VerhammeAnnemarie I. LuikBruno StrickerJoyce B. J. van MeursGuy Brusselle

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Treatment options in type-2 low asthma

Timothy S.C. HinksStewart J. LevineGuy Brusselle

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

2020

A cross-omics integrative study of metabolic signatures of chronic obstructive pulmonary disease

Ivana ProkicLies LahousseMaaike de VriesJun LiuMarita KalaojaJudith M. VonkDiana van der PlaatCleo van DiemenAshley van der SpekAlexandra Zhernakova et al.

A1 Journal Article in BMC PULMONARY MEDICINE

A new once-daily long-acting beta(2)-adrenoceptor agonist-inhaled corticosteroid combination therapy for asthma

Editorial material

Blood eosinophil level and lung function trajectories : cross-sectional and longitudinal studies in European cohorts

Ida MogensenJudith M. VonkSara WijnantXingwu ZhouH. Marike BoezenGuy BrusselleLies LahousseChrister JansonAndrei Malinovschi

A1 Journal Article in ERJ OPEN RESEARCH

Change in blood eosinophils following treatment with inhaled corticosteroids may predict long-term clinical response in COPD

Alexander G. MathioudakisAndras BikovPhilip FodenLies LahousseGuy BrusselleDave SinghJorgen Vestbo

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Charting extracellular transcriptomes in the human biofluid RNA atlas

Eva HulstaertAnnelien MorlionFrancisco Avila CobosKimberly VerniersJustine NuytensEveline Vanden EyndeNurten YigitJasper AnckaertAnja GeertsPieter Hindryckx et al.

A1 Journal Article in CELL REPORTS

Chronic obstructive pulmonary disease and related phenotypes : polygenic risk scores in population-based and case-control cohorts

Matthew MollPhuwanat SakornsakolpatNick ShrineBrian D. HobbsDawn L. DeMeoCatherine JohnAnna L. GuyattMichael J. McGeachieSina A. GharibMa'en Obeidat et al.

A1 Journal Article in LANCET RESPIRATORY MEDICINE

Chronic oral corticosteroids use and persistent eosinophilia in severe asthmatics from the Belgian severe asthma registry

Simon GraffSarah VanwynsbergheGuy BrusselleS. HanonC. SohyL. J. DupontR. PecheA. MichilsC. PiletteGuy Joos et al.

A1 Journal Article in RESPIRATORY RESEARCH

Core outcome set for the management of acute exacerbations of chronic obstructive pulmonary disease : the COS-AECOPD ERS Task Force study protocol

Alexander G. MathioudakisFekri AbrougAlvar AgustiPer BakkeKonstantinos BartziokasBianca BegheAndras BikovThomas BradburyGuy BrusselleCordula Cadus et al.

A1 Journal Article in ERJ OPEN RESEARCH

COVID-19 and biologics in severe asthma : data from the Belgian Severe Asthma Registry

Shane HanonGuy BrusselleMaud DeschampheleireRenaud LouisAlain MichilsRudi PecheCharles PilettePeter RummensDaniel SchuermansHelene Simonis et al.

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

COVID-19, asthma, and inhaled corticosteroids : another beneficial effect of inhaled corticosteroids?

Tania MaesKen BrackeGuy Brusselle

Editorial material

Effect of fixed-dose subcutaneous reslizumab on asthma exacerbations in patients with severe uncontrolled asthma and corticosteroid sparing in patients with oral corticosteroid-dependent asthma : results from two phase 3, randomised, double-blind, placebo-controlled trials

Jonathan A BernsteinJ Christian VirchowKevin MurphyJorge Fernando MasperoJoshua JacobsYochai AdirMarc HumbertMario CastroDouglas A MarstellerJennifer McElhattan et al.

A1 Journal Article in LANCET RESPIRATORY MEDICINE

Expanding the spectrum of European Respiratory Society official scientific documents : short documents complement clinical practice guidelines, statements and technical standards

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Editorial material

Expression of ACE2, the SARS-CoV-2 receptor, in lung tissue of patients with type 2 diabetes

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A1 Journal Article in DIABETES

F-ENO as a biomarker guide for inhaled corticosteroid step down in patients with mild-to-moderate well-controlled asthma

Anh Tuan Dinh-XuanGuy Brusselle

Editorial material

GINA fosters World Asthma Day 2020 to prevent asthma deaths

Louis-Philippe BouletHelen K. ReddelChris BrightlingGuy Brusselle

Editorial material

Increased expression of ACE2, the SARS-CoV-2 entry receptor, in alveolar and bronchial epithelium of smokers and COPD subjects

Merel JacobsHannelore Van EeckhoutteSara WijnantWim JanssensGuy JoosGuy BrusselleKen Bracke

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Inhaled corticosteroids and COVID-19 reply

Tania MaesKen BrackeGuy Brusselle

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Innate defense proteins BPIFA1/B1 and microRNAs in the pathogenesis of COPD

Elise De SmetGuy BrusselleKen BrackePieter Mestdagh

Innate lymphoid cells in isocyanate-induced asthma : role of microRNA-155

Evy BlommeSharen ProvoostErica BazzanHannelore Van EeckhoutteMirjam RoffelLore PollarisAnnelies BontinckMatteo BonatoLouise VandenbrouckeFien Verhamme et al.

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Innate lymphoid cells in the pathogenesis of asthma and COPD

Evy BlommeTania MaesGuy Brusselle

International severe asthma registry (ISAR) : protocol for a global registry

J. Mark FitzGeraldTrung N. TranMarianna AlacquaAlan AltrajaVibeke BackerLeif BjermerUnnur BjornsdottirArnaud BourdinGuy BrusselleLakmini Bulathsinhala et al.

A1 Journal Article in BMC MEDICAL RESEARCH METHODOLOGY

International severe asthma registry mission statement

G. Walter CanonicaMarianna AlacquaAlan AltrajaVibeke BackerElisabeth BelLeif BjermerUnnur BjornsdottirArnaud BourdinGuy BrusselleGeorge C. Christoff et al.

A1 Journal Article in CHEST

Long-term safety and durability of mepolizumab in life-threatening/seriously debilitating severe eosinophilic asthma (SEA) : COSMEX

F. C. AlbersS. KhuranaE. BradfordM. GilsonR. PriceGuy BrusselleE. BelJ. M. FitzGeraldM. MasoliS. Korn et al.

Multinational cohort study of mortality in patients with asthma and severe asthma

Marjolein EngelkesMaria A. J. de RidderElisabeth SvenssonKlara BerencsiDaniel Prieto-AlhambraFrancesco LapiCarlo GiaquintoGino PicelliNada BoudiafFrank C. Albers et al.

A1 Journal Article in RESPIRATORY MEDICINE

Next-generation Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines for allergic rhinitis based on Grading of Recommendations Assessment, Development and Evaluation (GRADE) and real-world evidence

Jean BousquetHolger J SchünemannAkdis TogiasClaus BachertMartina ErholaPeter HellingsLudger KlimekOliver PfaarDana WallaceIgnacio Ansotegui et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Objectives, design and main findings until 2020 from the Rotterdam Study

M. Arfan IkramGuy BrusselleMohsen GhanbariAndre GoedegebureM. Kamran IkramMaryam KavousiBrenda C. T. KieboomCaroline C. W. KlaverRobert J. de KnegtAnnemarie I. Luik et al.

A1 Journal Article in EUROPEAN JOURNAL OF EPIDEMIOLOGY

Prevalence and incidence of, and risk factors for chronic cough in the adult population : the Rotterdam Study

Johnmary T. ArinzeEmmely W. de RoosLeila KarimiKatia VerhammeBruno H. StrickerGuy Brusselle

A1 Journal Article in ERJ OPEN RESEARCH

Recent advances in chronic obstructive pulmonary disease pathogenesis : from disease mechanisms to precision medicine

Corry-Anke BrandsmaMaarten Van den BergeTillie-Louise HackettGuy BrusselleWim Timens

A1 Journal Article in JOURNAL OF PATHOLOGY

Safety of reslizumab in uncontrolled asthma with eosinophilia : a pooled analysis from 6 trials

J. Christian VirchowRohit KatialGuy BrusselleYael ShalitMargaret GarinMirna McDonaldMario Castro

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE

Severe eosinophilic asthma with nasal polyposis : a phenotype for improved sinonasal and asthma outcomes with mepolizumab therapy

Peter HowarthGeoffrey ChuppLinda M. NelsenEric S. BradfordDaniel J. BrattonSteven G. SmithFrank C. AlbersGuy BrusselleClaus Bachert

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The global significance of PRISm : how data from low- and middle-income countries link physiology to inflammation

Sara WijnantLies LahousseGuy Brusselle

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

The impact of the prostaglandin D₂ receptor 2 and its downstream effects on the pathophysiology of asthma

Christopher E BrightlingGuy BrussellePablo Altman

A1 Journal Article in ALLERGY

The role of miR-155 in cigarette smoke-induced pulmonary inflammation and COPD

Elise De SmetHannelore Van EeckhoutteFrancisco Avila CobosEvy BlommeFien VerhammeSharen ProvoostSTIJN VERLEDENKoen VenkenTania MaesGuy Joos et al.

A1 Journal Article in MUCOSAL IMMUNOLOGY

Trajectory and mortality of preserved ratio impaired spirometry : the Rotterdam Study

Sara WijnantEmmely de RoosMaryam KavousiBruno Hugo StrickerNatalie TerzikhanLies LahousseGuy Brusselle

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Translational research into the effects of cigarette smoke on inflammatory mediators and epithelial TRPV1 in Crohn’s disease

Liesbeth AllaisStephanie VerschuereTania MaesRebecca De SmetSarah DevrieseBryan GonzalesHarald PeetersKoen Van CrombruggenClaus BachertMartine De Vos et al.

A1 Journal Article in PLOS ONE

2019

Adherence to controller therapy in chronic obstructive pulmonary disease : real life setting

Leila KarimiEsme J BaanTiana GeeraerdJohan Van der LeiBruno HC StrickerGuy BrusselleLies LahousseKatia M Verhamme

Adherence trajectories in asthmatic patients

Esme BaanLeila KarimiAstrid HeeremansGuy BrusselleMiriam SturkenboomHettie M JanssensLies LahousseJohan C de JongsteKatia Verhamme

Association between inhaled corticosteroid therapy for COPD and diabetes onset and progression

K KostikasJ VoorhamN RocheJ StephensH ParkR FogelA ClemensGuy BrusselleD Price

Association of alcohol consumption with allergic disease and asthma : a multi-centre Mendelian randomization analysis

Tea SkaabyTuomas O. KilpelainenAmy E. TaylorYuvaraj MahendranAndrew WongTarunveer S. AhluwaliaLavinia PaternosterStella TrompetDavid J. StottClaudia Flexeder et al.

A1 Journal Article in ADDICTION

Association of elevated fractional exhaled nitric oxide concentration and blood eosinophil count with severe asthma exacerbations

David B PriceSinthia Bosnic-AnticevichIan D PavordNicolas RocheDavid MG HalpinLeif BjermerOmar S UsmaniGuy BrusselleSimon Wan Yau MingSarang Rastogi

A1 Journal Article in CLINICAL AND TRANSLATIONAL ALLERGY

Atherosclerotic calcification in major vessel beds in chronic obstructive pulmonary disease : the Rotterdam Study

Lies LahousseDaniel BosSara WijnantMaryam KavousiBruno H. StrickerAad van der LugtMeike W. VernooijGuy Brusselle

A1 Journal Article in ATHEROSCLEROSIS

Azithromycin during acute chronic obstructive pulmonary disease exacerbations requiring hospitalization (BACE) : a multicenter, randomized, double-blind, placebo-controlled trial

Kristina VermeerschMaria GabrovskaJoseph AumannIngel K DemedtsJean-Louis CorhayEric MarchandHans SlabbynckChristel HaenebalckeMichiel HaerensShane Hanon et al.

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Beta(2)-adrenergic receptor (ADRB2) gene polymorphisms and risk of COPD exacerbations : the Rotterdam study

Leila KarimiLies LahousseMohsen GhanbariNatalie TerzikhanAndre G. UitterlindenJohan van der LeiGuy BrusselleBruno H. StrickerKatia Verhamme

A1 Journal Article in JOURNAL OF CLINICAL MEDICINE

Bone morphogenetic protein 6 (BMP-6) modulates lung function, pulmonary iron levels and cigarette smoke-induced inflammation

Fien VerhammeElise De SmetWannes Van HoosteJoris DelangheSE VerledenGuy JoosGuy BrusselleKen Bracke

A1 Journal Article in MUCOSAL IMMUNOLOGY

Chronic Airway Diseases Early Stratification (CADSET) : a new ERS clinical research collaboration

Alvar AgustiRosa FanerGavin DonaldsonElise HeuvelinRobab Breyer-KohansalErik MelenAnke H Maitland-van der ZeeJorgen VestboJames P AllinsonLowie EGW Vanfleteren et al.

Editorial material

Chronic obstructive pulmonary disease and the development of atrial fibrillation

Maxim GrymonprezVincent VakaetMaryam KavousiBruno H StrickerM Arfan IkramJan HeeringaOscar H FrancoGuy BrusselleLies Lahousse

A1 Journal Article in INTERNATIONAL JOURNAL OF CARDIOLOGY

Chronic use of oral corticosteroids in severe asthmatics in the Belgian Severe Asthma Registry (BSAR)

S VanwynsbergheF SchleichR LouisO VandenplasC PiletteR PecheGuy JoosS DobbelaereD SchuermansS Hanon et al.

DNA methylation is associated with lung function in never smokers

Maaike de VriesIvana NedeljkovicDiana A. van der PlaatAlexandra ZhernakovaLies LahousseGuy BrusselleNajaf AminCornelia M. van DuijnJudith M. VonkH. Marike Boezen

A1 Journal Article in RESPIRATORY RESEARCH

Does maintenance azithromycin reduce asthma exacerbations? : an individual participant data meta-analysis

Sarah A HilesVanessa M McDonaldMichelle GuilherminoGuy BrussellePeter G Gibson

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Dupilumab effect on asthma control and health-related quality of life in patients with oral corticosteroid-dependent severe asthma with comorbid chronic rhinosinusitis with and without nasal polyps

M CastroKF RabeGuy BrusselleMS RiceP RoweY DenizS KamatA Khan

Effect of a 3-month low-dose azithromycin intervention for COPD exacerbations requiring hospitalization on subsequent respiratory events and mortality : the BACE trial

W JanssensK VermeerschT TroostersGuy Brusselle

Efficacy of mepolizumab in patients with severe eosinophilic asthma by age of asthma onset : meta-analysis of two phase III trials

FC AlbersNA HananiaM KraftDJ BrattonE BradfordSG SmithCM PrazmaGuy Brusselle

ERS/EAACI statement on severe exacerbations in asthma in adults : facts, priorities and key research questions

Arnaud BourdinLeif BjermerChristopher BrightlingGuy BrussellePascal ChanezKian Fan ChungAdnan CustovicZuzana DiamantSarah DiverRatko Djukanovic et al.

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Exacerbation rate reduction according to baseline blood eosinophilic count in patients with asthma treated with ICS/LABA maintenance and reliever therapy

Guy BrusselleA PapiG NicoliniL SantoroD Guastalla

Expression of receptor interacting protein kinase-3 and mixed lineage kinase domain-like protein in patients with COPD

Fien VerhammeHannelore Van EeckhoutteT Buyle-HuybrechtGuy BrussellePeter VandenabeeleTom Vanden BergheKen Bracke

GDF-15 in pulmonary and critical care medicine

Fien VerhammeChristine M FreemanGuy BrusselleKen BrackeJeffrey L Curtis

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations

Phuwanat SakornsakolpatDmitry ProkopenkoMaxime LamontagneNicola F ReeveAnna L GuyattVictoria E JacksonNick ShrineDandi QiaoTraci M BartzDeog Kyeom Kim et al.

A1 Journal Article in NATURE GENETICS

GINA 2019 : a fundamental change in asthma management

Helen K ReddelJ Mark FitzGeraldEric D BatemanLeonard B BacharierAllan BeckerGuy BrusselleRoland BuhlAlvaro A CruzLouise FlemingHiromasa Inoue et al.

Editorial material

Guidance to 2018 good practice : ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma

J BousquetA BedbrookW CzarlewskiGL OnoratoS ArnavielheD LauneE Mathieu-DupasJ FonsecaE CostaO Lourenco et al.

A1 Journal Article in CLINICAL AND TRANSLATIONAL ALLERGY

Lifetime risk and multimorbidity of non-communicable diseases and disease-free life expectancy in the general population : a population-based cohort study

Silvan LicherAlis HeshmatollahKimberly D van der WillikBruno HCh StrickerRikje RuiterEmmely W de RoosLies LahoussePeter J KoudstaalAlbert HofmanLana Fani et al.

A1 Journal Article in PLOS MEDICINE

Limited overlap in significant hits between genome-wide association studies on two airflow obstruction definitions in the same population

Diana A van der PlaatJudith M VonkLies LahousseKim de JongAlen FaizIvana NedeljkovicNajaf AminCleo C van DiemenGuy BrusselleYohan Bosse et al.

A1 Journal Article in BMC PULMONARY MEDICINE

Long-term safety and clinical benefit of mepolizumab in patients with the most severe eosinophilic asthma : the COSMEX study

Sandhya KhuranaGuy BrusselleElisabeth H. BelJ. Mark FitzGeraldMatthew MasoliStephanie KornMotokazu KatoFrank C. AlbersEric S. BradfordMartyn J. Gilson et al.

A1 Journal Article in CLINICAL THERAPEUTICS

Modulation of innate lymphoid cell subsets in a mouse model of isocyanate-induced asthma

Evy BlommeSarah ProvoostL PollarisHannelore Van EeckhoutteL VandenbrouckeFien VerhammeGuy JoosGuy BrusselleJ VanoirbeekTania Maes

Moving forward from drug-centred to patient-centred research

Denis LacombeColm O'MorainBarbara CasadeiKate HillElsa MateusRik LoriesGuy Brusselle

Editorial material

Necroptosis is activated in and drives pathogenesis of COPD

M FrickerZ LuHannelore Van EeckhoutteG LiuFien VerhammeT Buyle-HuybrechtGuy BrusselleJ MurphyKen BrackeP Hansbro

Newborn DNA-methylation, childhood lung function, and the risks of asthma and COPD across the life course

Herman T den DekkerKimberley BurrowsJanine F FelixLucas A SalasIvana NedeljkovicJin YaoSheryl L Rifas-ShimanCarlos Ruiz-ArenasN AminMariona Bustamante et al.

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Next-generation ARIA care pathways for rhinitis and asthma : a model for multimorbid chronic diseases

J Jean BousquetHolger J SchunemannAlkis TogiasMarina ErholaPeter W HellingsTorsten ZuberbierIoana AgacheIgnacio J AnsoteguiJosep M AntoClaus Bachert et al.

A1 Journal Article in CLINICAL AND TRANSLATIONAL ALLERGY

Next-generation care pathways for allergic rhinitis and asthma multimorbidity : a model for multimorbid non-communicable diseases : meeting report (part 1)

Jean BousquetNhan Pham-ThiAnna BedbrookIoana AgacheIsabella Annesi-MaesanoIgnacio AnsoteguiJosep M AntoClaus BachertSamuel BenvenisteMike Bewick et al.

A1 Journal Article in JOURNAL OF THORACIC DISEASE

Next-generation care pathways for allergic rhinitis and asthma multimorbidity : a model for multimorbid non-communicable diseases : meeting report (part 2)

Jean BousquetNhan Pham-ThiAnna BedbrookIoana AgacheIsabella Annesi-MaesanoIgnacio AnsoteguiJosep M AntoClaus BachertSamuel BenvenisteMike Bewick et al.

A1 Journal Article in JOURNAL OF THORACIC DISEASE

Occupational exposure to gases/fumes and mineral dust affect DNA methylation levels of genes regulating expression

Diana van Der PlaatJudith M VonkNatalie TerzikhanKim de JongMaaike de VriesSacha La Bastide-van GemertCleo C van DiemenLies LahousseGuy BrusselleIvana Nedeljkovic et al.

A1 Journal Article in HUMAN MOLECULAR GENETICS

Omalizumab as alternative to chronic use of oral corticosteroids in severe asthma

Paraskevi KatsaounouRoland BuhlGuy BrussellePascal PfisterRafael MartinezUlrich WahnJean Bousquet

A1 Journal Article in RESPIRATORY MEDICINE

Omega-3 fatty acids and genome-wide interaction analyses reveal DPP10-pulmonary function association

Jiayi XuNathan C GaddisTraci M BartzRuixue HouAni W ManichaikulNathan PankratzAlbert V SmithFangui SunNatalie TerzikhanChristina A Markunas et al.

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Prevalence and burden of asthma in China : time to act

Guy BrusselleFanny Wai-San Ko

Editorial material

Prevalence and characteristics of asthma-chronic obstructive pulmonary disease overlap in routine primary care practices

Jerry A KrishnanAnjan NibberAlison ChisholmDavid PriceEric D BatemanLeif BjermerJob FM van BovenGuy BrusselleRichard W CostelloRonald J Dandurand et al.

A1 Journal Article in ANNALS OF THE AMERICAN THORACIC SOCIETY

Prevalence of asthma and COPD and blood eosinophil count in a middle-aged Belgian population

Sara WijnantLies LahousseMarc De BuyzereGuy BrusselleErnst Rietzschel

A1 Journal Article in JOURNAL OF CLINICAL MEDICINE

Quality standards in respiratory real-life effectiveness research : the REal Life EVidence AssessmeNt Tool (RELEVANT) : report from the Respiratory Effectiveness Group - European Academy of Allergy and Clinical Immunology Task Force

Nicolas RocheJonathan D CampbellJerry A KrishnanGuy BrusselleAlison ChisholmLeif BjermerMike ThomasEric van GanseMaarten van den BergeGeorge Christoff et al.

A1 Journal Article in CLINICAL AND TRANSLATIONAL ALLERGY

Real-life effectiveness of omalizumab in difficult-to-treat versus severe asthma : a national cohort study in Belgium

Katia VerhammeCatherine LucetAlain Van MeerhaegheGuy BrusselleMarie-Laurence Lambert

A1 Journal Article in ERJ OPEN RESEARCH

Sarcopenia in COPD : a systematic review and meta-analysis

Elizabeth BenzKaterina TrajanoskaLies LahousseJosje D SchoufourNatalie TerzikhanEmmely de RoosGerdien B de JongeRoss WilliamsOscar H FrancoGuy Brusselle et al.

A1 Journal Article in EUROPEAN RESPIRATORY REVIEW

Simultaneous inhibition of thymic stromal lymphopoietin, IL-33 and IL-25 : a therapeutic option in asthma?

Tania MaesGuy Brusselle

Editorial material

The association between dietary protein intake, energy intake and physical frailty : results from the Rotterdam Study

Josje D SchoufourOscar H FrancoJessica C Kiefte-de JongKaterina TrajanoskaBruno StrickerGuy BrusselleFernando RivadeneiraLies LahousseTrudy Voortman

A1 Journal Article in BRITISH JOURNAL OF NUTRITION

The ERS fellowship portfolio : fostering excellence and diversity

Rory E MortyLouise E DonnellyDaiana StolzNicolas RocheTobias WelteKathryn A ForrestChristopher E BrightlingGuy Brusselle

Editorial material

The human biofluid RNA atlas : expanding the liquid biopsy field beyond the blood stream

Eva HulstaertKimberly VerniersJustine NuytensEveline Vanden EyndeNurten YigitJasper AnckaertAnja GeertsPeggy JacquesGuy BrusselleTHIERRY DERVEAUX et al.

The once-daily fixed-dose combination of olodaterol and tiotropium in the management of COPD : current evidence and future prospects

Eric DeromGuy BrusselleGuy Joos

A1 Journal Article in THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE

The REal Life EVidence AssessmeNt Tool (RELEVANT) : development of a novel quality assurance asset to rate observational comparative effectiveness research studies

Jonathan D CampbellRobert PerryNikolaos G PapadopoulosJerry KrishnanGuy BrusselleAlison ChisholmLeif BjermerMichael ThomasEric van GanseMaarten van den Berge et al.

A1 Journal Article in CLINICAL AND TRANSLATIONAL ALLERGY

Tralokinumab did not demonstrate oral corticosteroid-sparing effects in severe asthma

William W BusseGuy BrusselleStephanie KornPiotr KunaAntoine MagnanDavid CohenKarin BowenTeresa PiechowiakMillie M WangGene Colice

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Treatment failure and hospital readmissions in severe COPD exacerbations treated with azithromycin versus placebo - a post-hoc analysis of the BACE randomized controlled trial

Kristina VermeerschAnn BelmansKris BogaertsIwein GyselinckNina CardinaelsMaria GabrovskaJoseph AumannIngel K. DemedtsJean-Louis CorhayEric Marchand et al.

A1 Journal Article in RESPIRATORY RESEARCH

Update on immunogenicity in severe asthma : experience with mepolizumab

Hector G OrtegaErik MeyerGuy BrusselleKoichiro AsanoCharlene M PrazmaFrank C AlbersStephen A MallettSteve W YanceyGerald J Gleich

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE

Variability in total serum IgE over 1 year in severe asthmatics

Renaud LouisCharles PiletteOlivier MichelAlain MichilsGuy BrusselleAntoine PoskinJan Van SchoorKris DenhaerynckStefaan VancayzeeleIvo Abraham et al.

A1 Journal Article in ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY

2018

A genome-wide linkage study for chronic obstructive pulmonary disease in a Dutch genetic isolate identifies novel rare candidate variants

Ivana NedeljkovicNatalie TerzikhanJudith M VonkDiana A van der PlaatLies LahousseCleo C van DiemenBrian D HobbsDandi QiaoMichael H ChoGuy Brusselle et al.

A1 Journal Article in FRONTIERS IN GENETICS

A prospective, longitudinal study evaluating the baseline six-minute walk test as an individual reference value in systemic sclerosis patients

Els VandecasteeleKarin MelsensFilip De KeyserMichel De PauwEllen DeschepperSaskia DecumanYves PietteKristof ThevissenGuy BrusselleVanessa Smith

A1 Journal Article in CLINICAL AND EXPERIMENTAL RHEUMATOLOGY

After asthma : redefining airways diseases

Ian D PavordRichard BeasleyAlvar AgustiGary P AndersonElisabeth BelGuy BrussellePaul CullinanAdnan CustovicFrancine M DucharmeJohn V Fahy et al.

A1 Journal Article in LANCET

Anti-MDA5 positive dermatomyositis complicated with rapidly progressive interstitial lung disease : a case report

Eva De BackerFélix GremonprezGuy BrussellePieter DepuydtJo Van DorpeCarole Van HaverbekePieter GoeminneEric Derom

A1 Journal Article in ACTA CLINICA BELGICA

Association between blood eosinophil count and risk of readmission for patients with asthma : historical cohort study

Marjan KerkhofTrung N TranMaarten van den BergeGuy BrusselleGokul GopalanRupert CM JonesJanwillem WH KocksAndrew Menzies-GowJavier NuevoIan D Pavord et al.

A1 Journal Article in PLOS ONE

Association of innate defense proteins BPIFA1 and BPIFB1 with disease severity in COPD

Elise De SmetLeen SeysFien VerhammeBart M VanaudenaerdeGuy BrusselleColin D BingleKen Bracke

A1 Journal Article in INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Asthma and its comorbidities in middle-aged and older adults : the Rotterdam study

Emmely de RoosLies LahousseKatia VerhammeGert-Jan BraunstahlM Arfan IkramJohannes CCM in't VeenBruno HCh StrickerGuy Brusselle

A1 Journal Article in RESPIRATORY MEDICINE

Blood eosinophil levels as a biomarker in COPD

Guy BrusselleIan D PavordSarah LandisSteven PascoeSally LettisNikhil MorjariaNeil BarnesEmma Hilton

A1 Journal Article in RESPIRATORY MEDICINE

COPD GWAS variant at 19q13.2 in relation with DNA methylation and gene expression

Ivana NedeljkovicLies LahousseElena Carnero-MontoroAlen FaizJudith M VonkKim de JongDiana A van der PlaatCleo C van DiemenMaarten van den BergeMa'en Obeidat et al.

A1 Journal Article in HUMAN MOLECULAR GENETICS

COPD is associated with an increased risk of peripheral artery disease and mortality

Natalie TerzikhanLies LahousseKatia VerhammeOscar H FrancoArfan M IkramBruno H StrickerGuy Brusselle

A2 Journal Article in ERJ OPEN RESEARCH

DPP4, the Middle East respiratory syndrome coronavirus receptor, is upregulated in lungs of smokers and chronic obstructive pulmonary disease patients

Leen SeysW WidagdoFien VerhammeAlex KleinjanWim JanssensGuy JoosKen BrackeBart L HaagmansGuy Brusselle

A1 Journal Article in CLINICAL INFECTIOUS DISEASES

Dupilumab in patients with corticosteroid-dependent severe asthma : efficacy and safety results from the randomized, double-blind, placebo-controlled phase 3 LIBERTY ASTHMA VENTURE study

KF RabePK NairGuy BrusselleJF MasperoM CastroH ZhuH StaudingerG PirozziC AntoniN. Amin et al.

Efficacy and safety of dupilumab in glucocorticoid-dependent severe asthma

Klaus F RabeParameswaran NairGuy BrusselleJorge F MasperoMario CastroLawrence SherHongjie ZhuJennifer D HamiltonBrian N SwansonAsif H. Khan et al.

A1 Journal Article in NEW ENGLAND JOURNAL OF MEDICINE

ERS clinical research collaborations : underpinning research excellence

Chris BrightlingCeline GentonWerner BillTobias WelteMina GagaElise HeuvelinGuy Brusselle

Editorial material

Genetic and non-genetic determinants and clinical consequences of impaired lung function

Natalie TerzikhanGuy BrusselleBH StrickerLies LahousseKatia Verhamme

Heritability and genome-wide association study of diffusing capacity of the lung

Natalie TerzikhanFangui SunFien VerhammeHieab HH AdamsDaan LothKen BrackeBruno HC StrickerLies LahousseJosée DupuisGuy Brusselle et al.

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

IL-33 signalling contributes to pollutant-induced allergic airway inflammation

Katrien De GroveSharen ProvoostHarald BraunEvy BlommeAndrea Renate TeufelbergerOlga KryskoRudi BeyaertGuy BrusselleGuy JoosTania Maes

A1 Journal Article in CLINICAL AND EXPERIMENTAL ALLERGY

Influence of genetic variants on childhood lung function : the Generation R study

Sara S ShagiwalHerman T den DekkerJohan C de JongsteGuy BrusselleVincent WV JaddoeJanine F FelixLiesbeth Duijts

A1 Journal Article in PEDIATRIC ALLERGY AND IMMUNOLOGY

Insights in particulate matter-induced allergic airway inflammation : focus on the epithelium

Katrien De GroveSharen ProvoostGuy BrusselleGuy JoosTania Maes

A1 Journal Article in CLINICAL AND EXPERIMENTAL ALLERGY

Measures of subclinical cardiac dysfunction and increased filling pressures associate with pulmonary arterial pressure in the general population : results from the population-based Rotterdam Study

Ryan J BillarMaarten JG LeeningDaphne MerkusGuy BrusselleAlbert HofmanBruno HCh StrickerH Ardeschir GhofraniOscar H FrancoHenning GallJanine F Felix

A1 Journal Article in EUROPEAN JOURNAL OF EPIDEMIOLOGY

Meta-analysis across Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium provides evidence for an association of serum vitamin D with pulmonary function

Jiayi XuTraci M BartzGeetha ChittoorGudny EiriksdottirAni W ManichaikulFangui SunNatalie TerzikhanXia ZhouSarah L BoothGuy Brusselle et al.

A1 Journal Article in BRITISH JOURNAL OF NUTRITION

Meta-analysis of exome array data identifies six novel genetic loci for lung function

VE JacksonJC LatourelleLV WainAV SmithML GroveTM BartzM ObeidatMA ProvinceW GaoB Qaiser et al.

A2 Journal Article in WELLCOME OPEN RESEARCH

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

Florence DemenaisPatricia Margaritte-JeanninKathleen C BarnesWilliam OC CooksonJanine AltmuellerWei AngR Graham BarrTerri H BeatyAllan B BeckerJohn Beilby et al.

A1 Journal Article in NATURE GENETICS

Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function

Annah B WyssTamar SoferMi Kyeong LeeNatalie TerzikhanJennifer N NguyenLies LahousseJeanne C LatourelleAlbert Vernon SmithTraci M BartzMary F Feitosa et al.

A1 Journal Article in NATURE COMMUNICATIONS

New era for European Respiratory Society clinical practice guidelines : joining efficiency and high methodological standards

Marc MiravitllesThomy ToniaDavid RigauNicolas RocheCeline GentonValerie VaccaroTobias WelteMina GagaGuy Brusselle

Editorial material

Performance of database-derived severe exacerbations and asthma control measures in asthma : responsiveness and predictive utility in a UK primary care database with linked questionnaire data

Gene ColiceAlison ChisholmAlexandra L. DimaHelen K. ReddelAnnie BurdenRichard J. MartinGuy BrusselleTodor A. PopovJulie von ZiegenweidtDavid B. Price

A2 Journal Article in PRAGMATIC AND OBSERVATIONAL RESEARCH

Personalized medicine with biologics for severe type 2 asthma : current status and future prospects

Marie GodarChristophe BlanchetotHans de HaardBart LambrechtGuy Brusselle

A1 Journal Article in MABS

Physical activity and cause-specific mortality : the Rotterdam Study

Chantal M KoolhaasKlodian DhanaJosje D SchoufourLies LahousseFrank JA van RooijM Arfan IkramGuy BrusselleHenning TiemeierOscar H Franco

A1 Journal Article in INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Sarcopenia and its clinical correlates in the general population : the Rotterdam study

Katerina TrajanoskaJosje D SchoufourSirwan KL DarweeshElizabeth BenzCarolina Medina-GomezLouise JM AlferinkLies LahousseGuy BrusselleBruno StrickerSarwa Darwish Murad et al.

A1 Journal Article in JOURNAL OF BONE AND MINERAL RESEARCH

Serum phosphate levels are related to all-cause, cardiovascular and COPD mortality in men

Natalia Campos-ObandoLies LahousseGuy BrusselleBruno H StrickerAlbert HofmanOscar H FrancoAndré G UitterlindenM Carola Zillikens

A1 Journal Article in EUROPEAN JOURNAL OF EPIDEMIOLOGY

The European Respiratory Society : ensuring excellence through education best practice

Amy FarrMina GagaTobias WelteThierry TroostersGuy JoosCarlos Robalo CordeiroO Chris BurghuberGuy BrusselleChristina-Georgia GratziouAndrew Bush et al.

Editorial material

The European Respiratory Society's 10 principles for lung health

Ildiko HorvathMaeve BarryGuy BrusselleOtto Chris BurghuberAndrew BushCarlos Robalo CordeiroMina GagaChristina GratziouIsabel SaraivaDaiana Stolz et al.

Editorial material

The role of microRNA-155 in cigarette smoke-induced inflammation

Elise De SmetPieter MestdaghFrancisco Avila CobosEvy BlommeFien VerhammeSharen ProvoostTania MaesGuy JoosGuy BrusselleKen Bracke

The significance of eosinophilic inflammation in chronic obstructive pulmonary disease

Christopher B CooperGuy BrusselleSteven J PascoeIan D Pavord

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Toward effective prescription of inhaled corticosteroids in chronic airway disease

Zuzana DiamantGuy BrusselleRichard E Russell

Editorial material

Two years follow-up of an open-label pilot study of treatment with rituximab in patients with early diffuse cutaneous systemic sclerosis

Karin MelsensEls VandecasteeleEllen DeschepperValérie BadotDaniel BlockmansGuy BrusselleEllen De LangheMichel De PauwClaire DebusschereSaskia Decuman et al.

A1 Journal Article in ACTA CLINICA BELGICA

Understanding the role of the chromosome 15q25.1 in COPD through epigenetics and transcriptomics

Ivana NedeljkovicElena Carnero-MontoroLies LahousseDiana A van der PlaatKim de JongJudith M VonkCleo C van DiemenAlen FaizMaarten van den BergeMa'en Obeidat et al.

A1 Journal Article in EUROPEAN JOURNAL OF HUMAN GENETICS

Urgent need for pragmatic trial platforms in severe asthma

Charles PiletteChris BrightlingDenis LacombeGuy Brusselle

Editorial material

2017

A genome-wide linkage study for COPD in a Dutch genetic isolate

Ivana NedeljkovicNatalie TerzikhanJudith M VonkDiana A van der PlaatLies LahousseCleo C van DiemenGuy BrusselleH Marike BoezenCornelia M van DuijnNajaf Amin

Adherence to the 2015 Dutch dietary guidelines and risk of non-communicable diseases and mortality in the Rotterdam study

Trudy VoortmanJessica C Kiefte-de JongM Arfan IkramBruno H StrickerFrank JA van RooijLies LahousseHenning TiemeierGuy BrusselleOscar H FrancoJosje D Schoufour

A1 Journal Article in EUROPEAN JOURNAL OF EPIDEMIOLOGY

Association between blood eosinophil count and exacerbation risk in patients with asthma receiving medium- or high-dosage inhaled corticosteroids

Marjan KerkhofTrung N TranMaarten van den BergeGuy BrusselleGokul GopalanRupert JonesJanWillem KocksAndrew Menzies-GowJavier NuevoIan Pavord et al.

Association between blood eosinophil counts and risk of rehospitalization in patients with asthma

Marjan KerkhofTrung N TranMaarten van den BergeGuy BrusselleGokul GopalanRupert JonesJanWillem KocksAndrew Menzies-GowJavier NuevoIan Pavord et al.

Association between lutein intake and lung function in adults : the Rotterdam Study

Debora Melo van LentElisabeth TM LeermakersAlbert HofmanBruno H StrickerGuy BrusselleOscar H FrancoLies LahousseJessica C Kiefte-de Jong

A1 Journal Article in BRITISH JOURNAL OF NUTRITION

Azithromycin in uncontrolled asthma

Guy BrusselleIan Pavord

Editorial material

Blood eosinophil count and exacerbation risk in patients with COPD

Marjan KerkhofSamatha SonnappaDirkje S PostmaGuy BrusselleAlvar AgustiAntonio AnzuetoRupert JonesAlberto PapiIan PavordEmilio Pizzichini et al.

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Blood eosinophils and smoking history affect outcome with high dose N-acetylcysteine treatment in COPD

Alberto PapiGuy BrusselleFrancesco SergioMarco PannacciJinping ZhengGerard Criner

Care pathways for the selection of a biologic in severe asthma

Jean BousquetGuy BrusselleRoland BuhlWilliam W BusseAlvaro A CruzRatko DjukanovicChristian DomingoNicola A HananiaMarc HumbertAndrew Menzies Gow et al.

Editorial material

Comparing the use and onset of palliative care services in chronic obstructive pulmonary disease (COPD) and lung cancer : a population-based mortality follow-back survey

Charlotte ScheerensKim BeernaertGuy BrusselleJ CohenLuc DeliensKenneth Chambaere

Design of a frailty index among community living middle-aged and older people : the Rotterdam study

Josje D SchoufourNicole S ErlerLoes JaspersJessica C Kiefte-de JongTrudy VoortmanGijsbertus ZiereJan LindemansCaroline C KlaverHenning TiemeierBruno Stricker et al.

A1 Journal Article in MATURITAS

Development of a healthy aging score in the population-based Rotterdam study : evaluating age and sex differences

Loes JaspersJosje D SchoufourNicole S ErlerSirwan KL DarweeshMarileen LP PortegiesSanaz SedaghatLies LahousseGuy BrusselleBruno H StrickerHenning Tiemeier et al.

A1 Journal Article in JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION

Dietary mineral intake and lung cancer risk : the Rotterdam study

Taulant MukaBledar KrajaRikje RuiterLies LahousseCatherine E De KeyserAlbert HofmanOscar H FrancoGuy BrusselleBruno H StrickerJessica C Kiefte-de Jong

A1 Journal Article in EUROPEAN JOURNAL OF NUTRITION

Direct detection of circulating microRNAs unveiled the absence of microRNA-218-5p in smoker subjects : reply

Griet ConickxPieter MestdaghJo VandesompeleGuy BrusselleKen Bracke

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Dysregulation of type 2 innate lymphoid cells and TH2 cells impairs pollutant-induced allergic airway responses

Katrien De GroveSharen ProvoostRudi W HendriksAndrew NJ McKenzieLeen SeysSmitha KumarTania MaesGuy BrusselleGuy Joos

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Elevated GDF-15 contributes to pulmonary inflammation upon cigarette smoke exposure

Fien VerhammeLeen SeysElise De SmetSharen ProvoostW JanssensDirk ElewautGuy JoosGuy BrusselleKen Bracke

A1 Journal Article in MUCOSAL IMMUNOLOGY

End-stage cystic fibrosis lung disease is characterised by a diverse inflammatory pattern : an immunohistochemical analysis

Elise J LammertynElly VandermeulenHannelore BellonStephanie EveraertsStijn E VerledenKathleen Van den EyndeKen BrackeGuy BrussellePieter C GoeminneErik K Verbeken et al.

A1 Journal Article in RESPIRATORY RESEARCH

Epidemiology and impact of chronic bronchitis in chronic obstructive pulmonary disease

Lies LahousseLeen SeysGuy JoosOscar H FrancoBruno H StrickerGuy Brusselle

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Evaluation of the psychometric properties of the St George's Respiratory Questionnaire in patients with severe asthma

Linda M NelsenMargaret VernonHector OrtegaSarah M CockleSteven W YanceyGuy BrusselleFrank C AlbersPaul W Jones

A1 Journal Article in RESPIRATORY MEDICINE

Evidence for large-scale gene-by-smoking interaction effects on pulmonary function

Hugues AschardMartin D TobinDana B HancockDavid SkurnikAkshay SoodAlan JamesAlbert Vernon SmithAniw ManichaikulArchie CampbellBram P Prins et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

FeNO and blood eosinophils as biomarkers in predicting asthma exacerbations

S RastogiS Bosnic-AntievichI PavordN RocheD HalpinL BjermerOS UsmaniGuy BrusselleS Wan Yau MingS Halim et al.

Genes and pathways underlying susceptibility to impaired lung function in the context of environmental tobacco smoke exposure

K de JongJM VonkM ImbodenLies LahousseA HofmanGuy BrusselleNM Probst-HenschDS PostmaHM Boezen

A1 Journal Article in RESPIRATORY RESEARCH

Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis

Brian D HobbsKim de JongMaxime LamontagneYohan BosseNick ShrineMaria Soler ArtigasLouise V WainIan P HallVictoria E JacksonAnnah B Wyss et al.

A1 Journal Article in NATURE GENETICS

Genome-wide association study on the FEV1/FVC ratio in never-smokers identifies HHIP and FAM13A

Diana A van der PlaatKim de JongLies LahousseAlen FaizJudith M VonkCleo C. van DiemenIvana NedeljkovicNajaf AminGuy BrusselleAlbert Hofman et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Immunological diversity in phenotypes of chronic lung allograft dysfunction : a comprehensive immunohistochemical analysis

Elly VandermeulenElise LammertynStijn E VerledenDavid RuttensHannelore BellonMario RicciardiJana SomersKen BrackeKathleen Van Den EyndeThomas Tousseyn et al.

A1 Journal Article in TRANSPLANT INTERNATIONAL

Improvement in rhinosinusitis health related quality of life in patients with severe eosinophilic asthma

Linda NelsenEric S BradfordDaniel J BrattonFrank C AlbersGuy Brusselle

Increased levels of enzymes involved in local estradiol synthesis in chronic obstructive pulmonary disease

GFJ KoningsNL ReynaertB DelvouxFien VerhammeKen BrackeGuy BrusselleA RomanoJHJ Vernooy

A1 Journal Article in MOLECULAR AND CELLULAR ENDOCRINOLOGY

Increased risk of peripheral arterial disease in individuals with COPD

Natalie TerzikhanLies LahousseKatia VerhammeOscar FrancoGuy BrusselleBruno Stricker

Influence of chronic azithromycin treatment on the composition of the oropharyngeal microbial community in patients with severe asthma

Guido Lopes dos Santos SantiagoGuy BrusselleKenny DauwePieter DeschaghtChris VerhofstedeDries VaneechoutteEllen DeschepperPaul JordensGuy JoosMario Vaneechoutte

A1 Journal Article in BMC MICROBIOLOGY

microRNA profiling in lung tissue and bronchoalveolar lavage of cigarette smoke-exposed mice and in COPD patients : a translational approach

Griet ConickxFrancisco Avila CobosMaarten van den BergeAlen FaizWim TimensPieter S. HiemstraGuy JoosGuy BrussellePieter MestdaghKen Bracke

A1 Journal Article in SCIENTIFIC REPORTS

MicroRNA profiling reveals a role for microRNA-218-5p in the pathogenesis of chronic obstructive pulmonary disease

Griet ConickxPieter MestdaghFrancisco Avila CobosFien VerhammeTania MaesBart M VanaudenaerdeLeen SeysLies LahousseRichard Y KimAlan C Hsu et al.

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD

Hoeke A BaarsmaWioletta Skronska-WasekKathrin MutzeFlorian CiolekDarcy E WagnerGerrit John-SchusterKatharina HeinzelmannAndreas GüntherKen BrackeMaylis Dagouassat et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Peripheral artery disease in patients with chronic obstructive pulmonary disease

Guy BrusselleKen BrackeMichel De Pauw

Editorial material

Prevalence and incidence of pulmonary arterial hypertension : 10-year follow-up of an unselected systemic sclerosis cohort

Els VandecasteeleKarin MelsensKristof ThevissenMichel De PauwEllen DeschepperSaskia DecumanYves PietteFilip De KeyserGuy BrusselleVanessa Smith

A2 Journal Article in JOURNAL OF SCLERODERMA AND RELATED DISORDERS

Prevalence of hypertension among elderly asthmatics : the Rotterdam Study

Emmely De RoosLies LahousseArfan IkramBruno StrickerGuy BrusselleKatia Verhamme

Pulmonary artery to aorta ratio and risk of all-cause mortality in the general population : the Rotterdam Study

Natalie TerzikhanDaniel BosLies LahousseLennard WolffKatia MC VerhammeMaarten JG LeeningJanine F FelixHenning GallHossein A GhofraniOscar H Franco et al.

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Pulmonary function and diffusion capacity are associated with pulmonary arterial systolic pressure in the general population : the Rotterdam study

Daan W LothLies LahousseMaarten JG LeeningBouwe P KrijtheJanine F FelixHenning GallAlbert HofmanH Ardeschir GhofraniOscar H FrancoBruno H Stricker et al.

A1 Journal Article in RESPIRATORY MEDICINE

Qualitative evaluation of the St George's Respiratory Questionnaire in patients with severe asthma

Linda M NelsenMiriam KimelLindsey T MurrayHector OrtegaSarah M CockleSteven W YanceyGuy BrusselleFrank C AlbersPaul W Jones

A1 Journal Article in RESPIRATORY MEDICINE

Reduced frizzled receptor 4 expression prevents WNT/β-catenin-driven alveolar lung repair in chronic obstructive pulmonary disease

Wioletta Skronska-WasekKathrin MutzeHoeke A BaarsmaKen BrackeHani N AlsafadiMareike LehmannRita CostaMariano StornaiuoloEttore NovellinoGuy Brusselle et al.

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Reslizumab in eosinophilic asthma : a review

Emma D DeeksGuy Brusselle

A1 Journal Article in DRUGS

Reslizumab in patients with inadequately controlled late-onset asthma and elevated blood eosinophils

Guy BrusselleMatthew GerminaroSivan WeissJames Zangrilli

A1 Journal Article in PULMONARY PHARMACOLOGY & THERAPEUTICS

Role of microRNAs in the pathogenesis of chronic obstructive pulmonary disease (COPD)

Griet ConickxGuy BrusselleKen Bracke

Role of the six-minute walk test in systemic sclerosis : five years evolution

Els VandecasteeleKarin MelsensFilip De KeyserMichel De PauwEllen DeschepperSaskia DecumanYves PietteKristof ThevissenGuy BrusselleVanessa Smith

Screening for pulmonary arterial hypertension in an unselected prospective systemic sclerosis cohort

Els VandecasteeleBENNY DRIEGHEKarin MelsensKristof ThevissenMichel De PauwEllen DeschepperSaskia DecumanCarolien BonroyYves PietteFilip De Keyser et al.

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Sex-differences in mortality within the COPD chronic bronchitis phenotype

Lies LahousseLeen SeysGuy JoosOscar FrancoBruno StrickerGuy Brusselle

Sex-specific genetic risk factors for chronic obstructive pulmonary disease

Guy BrusselleLies Lahousse

Editorial material

Six-minute walk test in or out in evaluation of systemic sclerosis patients?

Els VandecasteeleKristof ThevissenKarin MelsensFilip De KeyserMichel De PauwEllen DeschepperSaskia DecumanYves PietteGuy BrusselleVanessa Smith

A1 Journal Article in CLINICAL AND EXPERIMENTAL RHEUMATOLOGY

Sputum neutrophil elastase as a biomarker for disease activity in bronchiectasis

Guy BrusselleEva Van Braeckel

Editorial material

Stratification of eosinophilic asthma patients treated with reslizumab and GINA Step 4 or 5 therapy

Guy BrusselleJanice CanvinSivan WeissShawn X SunRoland Buhl

A2 Journal Article in ERJ OPEN RESEARCH

Systeemsclerose

Els VandecasteeleMichel De PauwEric DeromGuy BrusselleSofie De SchepperFilip De Keyser

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Taken to task : what is and is not an appropriate response to an ERS guidelines task force?

Guy JoosAndrew BushOtto Chris BurghuberCarlos Robalo CordeiroMina GagaG John GibsonChristina GratziouDavid RigauGernot RohdeDan Smyth et al.

Editorial material

The role of dicer in alveolar macrophages and dendritic cells in smoke-induced inflammation

Elise De SmetPieter MestdaghS ProvoostLeen SeysGuy JoosKarim VermaelenGuy BrusselleKen Bracke

The Rotterdam study : 2018 update on objectives, design and main results

M Arfan IkramGuy BrusselleSarwa Darwish MuradCornelia M van DuijnOscar H FrancoAndr GoedegebureCaroline CW KlaverTamar EC NijstenRobin P PeetersBruno H Stricker et al.

A1 Journal Article in EUROPEAN JOURNAL OF EPIDEMIOLOGY

2016

A qualitative interpretation of challenges associated with helping patients with multiple chronic diseases identify their goals

Pauline BoeckxstaensSara WillemsMieke LanssensCharlotte DecuypereGuy BrusselleThomas KühleinJan De MaeseneerAn De Sutter

A2 Journal Article in JOURNAL OF COMORBIDITY

Aggravation of allergic airway inflammation by cigarette smoke in mice is CD44-dependent

Smitha KumarEllen LanckackerMieke DentenerKen BrackeSharen ProvoostKatrien De GroveGuy BrusselleEmiel WoutersTania MaesGuy Joos

A1 Journal Article in PLOS ONE

Assessment of sensitivity to change of the European Scleroderma Study Group activity index

Karin MelsensFilip De KeyserSaskia DecumanGuy BrusselleMichel De PauwEllen DeschepperKatelijne De WildeDirk ElewautYVES PIETTEEls Vandecasteele et al.

A1 Journal Article in CLINICAL AND EXPERIMENTAL RHEUMATOLOGY

Asthma inflammatory phenotypes show differential microRNA expression in sputum

Tania MaesFrancisco Avila CobosFlorence SchleichValentina SorbelloMonique HenketKatleen De PreterKen BrackeGriet ConickxClaire MesnilJo Vandesompele et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

AZALEA trial highlights antibiotic overuse in acute asthma attacks

Guy BrusselleEva Van Braeckel

Editorial material

Cardiac effects of current treatments of chronic obstructive pulmonary disease

Lies LahousseKatia VerhammeBruno H StrickerGuy Brusselle

A1 Journal Article in LANCET RESPIRATORY MEDICINE

Changes in initial COPD treatment choice over time and factors influencing prescribing decisions in UK primary care : in UK primary care: a real-world, retrospective, observational

Kevin Gruffydd-JonesGuy BrusselleRupert JonesMarc MiravitllesMichael BaldwinRebecca StewartAnna RigazioEmily DavisDorothy L KeiningerDavid Price

A1 Journal Article in NPJ PRIMARY CARE RESPIRATORY MEDICINE

Characterization and quantification of innate lymphoid cell subsets in human lung

Katrien De GroveSharen ProvoostFien VerhammeKen BrackeGuy JoosTania MaesGuy Brusselle

A1 Journal Article in PLOS ONE

Chronic cigarette smoke exposure induces microbial and inflammatory shifts and mucin changes in the murine gut

Liesbeth AllaisFrederiek-Maarten KerckhofStephanie VerscheureKen BrackeRebecca De SmetDebby LaukensPieter Van den AbbeeleMartine De VosNico BoonGuy Brusselle et al.

A1 Journal Article in ENVIRONMENTAL MICROBIOLOGY

Chronic obstructive pulmonary disease and sudden cardiac death: a systematic review

Marten E van den BergBruno H StrickerGuy BrusselleLies Lahousse

A1 Journal Article in TRENDS IN CARDIOVASCULAR MEDICINE

Chronic obstructive pulmonary disease and the risk of stroke: the Rotterdam study

Marileen L PortegiesLies LahousseGuy JoosAlbert HofmanPeter J KoustaalBruno H StrickerGuy BrusselleM Arfan Ikram

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cigarette smoking and inflammatory bowel disease : insights into microbial and immune homeostasis

Liesbeth AllaisClaude CuvelierGuy Brusselle

Determinants and impact of suboptimal asthma control in Europe: the INTERNATIONAL CROSS-SECTIONAL AND LONGITUDINAL ASSESSMENT ON ASTHMA CONTROL (LIAISON) study

Fulvio BraidoGuy BrusselleDaniele GuastallaEleonora IngrassiaGabriele NicoliniDavid PriceNicolas RocheJoan B SorianoHeinrich Worth

A1 Journal Article in RESPIRATORY RESEARCH

Efficacy of tiotropium-olodaterol fixed-dose combination in COPD

Eric DeromGuy BrusselleGuy Joos

A1 Journal Article in INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Epidemiology of chronic bronchitis in chronic obstructive pulmonary disease (COPD)

Leen SeysLies LahousseGuy JoosA HofmanB StrickerGuy Brusselle

LncRNAs in the context of Chronic Obstructive Pulmonary Disease (COPD) are associated to immune response and metabolism of xenobiotics

Francisco Avila CobosKen BrackeJo VandesompeleKimberly VerniersGuy JoosKatleen De PreterGuy BrussellePieter Mestdagh

Lung function abnormalities in smokers with ischemic heart disease

Frits ME FranssenJoan B SorianoNicolas RochePaul H BloomfieldGuy BrusselleLeonardo M FabbriFrancisco García-RioMark T KearneyNamhee KwonBo Lundbäck et al.

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Meta-analysis of the association of serum vitamin D with pulmonary function

J XuTM BartzG ChittoorG EiriksdottirAC Frazier-WoodLies LahousseJ LatourelleAW ManichaikulF SunNatalie Terzikhan et al.

Microrna-218-5p is implicated in the pathogenesis of chronic obstructive pulmonary disease

Griet ConickxPieter MestdaghFrancisco Avila CobosFien VerhammeTania MaesBM VanaudenaerdeLies LahousseGuy JoosJo VandesompeleKen Bracke et al.

Mucosal immunity in COPD : from mucociliary dysfunction to lymphoid follicles

Leen SeysGuy BrusselleKen Bracke

Prevalence and incidence of COPD in smokers and non-smokers: the Rotterdam study

Natalie TerzikhanKatia MC VerhammeAlbert HofmanBruno H StrickerGuy BrusselleLies Lahousse

A1 Journal Article in EUROPEAN JOURNAL OF EPIDEMIOLOGY

Pro- and anti-inflammatory role of ChemR23 signaling in pollutant-induced inflammatory lung responses

Sharen ProvoostKatrien De GroveGraeme L FraserVincent J LannoyKurt TournoyGuy BrusselleTania MaesGuy Joos

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Prostaglandin D₂ receptor antagonism: a novel therapeutic option for eosinophilic asthma?

Guy BrusselleSharen ProvoostTania Maes

Editorial material

Risk of frailty in elderly with COPD : a population-based study

Lies LahousseGijsbertus ZiereVincentius JA VerlindenM Carola ZillikensAndré G UitterlindenFernando RivadeneiraHenning TiemeierGuy JoosAlbert HofmanM Arfan Ikram et al.

A1 Journal Article in JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Rol van microRNA in neutrofiel astma

Tania MaesFrancisco Avila CobosFlorence SchleichValentina SorbelloMonique HenketKatleen De PreterKen BrackeGriet ConickxClaire MesnilJo Vandesompele et al.

A4 Journal Article in BLOEDVATEN HART LONGEN

Screening for pulmonary arterial hypertension in an unselected prospective systemic sclerosis cohort : the DETECT algorithm vs. the 2009 European Society of Cardiology/European Respiratory Society guidellines on pulmonary hypertension

Els VandecasteeleBENNY DRIEGHEKarin MelsensKristof ThevissenMichel De PauwEllen DeschepperSaskia DecumanFilip De KeyserCarolien BonroyYves Piette et al.

Serum phosphate is related to all-cause, cardiovascular and COPD mortality in men: the Rotterdam study

MC ZillikensN Campos-ObandoLies LahousseGuy BrusselleBH StrickerOH FrancoAG Uitterlinden

Six-minute walk test in systemic sclerosis : a systematic review and meta-analysis

Els VandecasteeleMichel De PauwFilip De KeyserSaskia DecumanEllen DeschepperYVES PIETTEGuy BrusselleVanessa Smith

A1 Journal Article in INTERNATIONAL JOURNAL OF CARDIOLOGY

Six-minute walk test in systemic sclerosis patients

Els VandecasteeleKarin MelsensFilip De KeyserMichel De PauwEllen DeschepperSaskia DecumanYVES PIETTEGuy BrusselleVanessa Smith

Six-minute walk test in systemic sclerosis patients without interstitial lung disease and pulmonary arterial hypertension

Els VandecasteeleKarin MelsensFilip De KeyserMichel De PauwEllen DeschepperSaskia DecumanYVES PIETTEGuy BrusselleVanessa Smith

Stabilization of microcirculation in patients with early systemic sclerosis with diffuse skin involvement following rituximab treatment: an open-label study

Vanessa SmithCarmen PizzorniValeria RiccieriSaskia DecumanGuy BrusselleMichel De PauwEllen DeschepperYVES PIETTEBarbara RuaroAlberto Sulli et al.

A1 Journal Article in JOURNAL OF RHEUMATOLOGY

Targeted therapy for older patients with uncontrolled severe asthma: current and future prospects

Emmely de RoosJCCM in 't VeenG-J BraunstahlLies LahousseGuy Brusselle

A1 Journal Article in DRUGS & AGING

The Belgian trial with azithromycin for acute COPD exacerbations requiring hospitalization: an investigator-initiated study protocol for a multicenter, randomized, double-blind, placebo-controlled trial

Kristina VermeerschMaria GabrovskaGriet DeslypereIngel K DemedtsHans SlabbynckJoseph AumannVincent NinaneGeert M VerledenThierry TroostersKris Bogaerts et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

The effects of lutein on respiratory health across the life course : a systematic review

Debora Melo van LentElisabeth T. M. LeermakersSirwan K. L. DarweeshEduardo M. MoreiraMyrte J. TielemansTaulant MukaAnna VitezovaRajiv ChowdhuryWichor M. BramerGuy Brusselle et al.

A2 Journal Article in CLINICAL NUTRITION ESPEN

The European Respiratory Society evaluates its 2013-2018 strategic plan implementation

Giovanni Battista MiglioriElisabeth BelGuy JoosMark ElliottGernot RohdeStephen T HolgateChristina GratziouDan SmythMina GagaCarlos Robeiro Cordeiro et al.

Editorial material

The ever-expanding ERS fellowship programmes : achievements over the past 3 years

Maria G BelvisiRory E MortyGernot RohdeMarc MriavitllesKathryn A ForrestCéline GentonNathalie RitterNikoleta LuludiAlbert JimenezDavid Rigau et al.

Editorial material

The evolving role of the community pharmacist : focus on medication screening in older patients with polypharmacy and medication counselling for patients with chronic obstructive pulmonary disease

Eline TommeleinKoen BousseryMirko PetrovicGuy Brusselle

The heart and pulmonary arterial hypertension in systemic sclerosis

Els VandecasteeleMichel De PauwGuy BrusselleSaskia DecumanYves PietteFilip De KeyserVanessa Smith

A1 Journal Article in ACTA CLINICA BELGICA

Treatable traits : toward precision medicine of chronic airway diseases

Alvar AgustiElisabeth BelMike ThomasClaus VogelmeierGuy BrusselleStephen HolgateMarc HumbertPaul JonesPeter G GibsonJørgen Vestbo et al.

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Understanding age-related diseases : report of the 2015 Ageing Summit

Lies LahousseEmmanuel MoyseSlavica KranticGuy Brusselle

Editorial material

Using a bronchial airway gene expression classifier

Karim VermaelenGuy Brusselle

Vilanterol fluticasone and mortality in comorbid COPD GOLD B

Editorial material

2015

Airway surface dehydration aggravates cigarette smoke-induced hallmarks of COPD in mice

Leen SeysFien VerhammeLisa DupontElke DesauterJulia DuerrAyca Seyhan AgircanGriet ConickxGuy JoosGuy BrusselleMarcus A Mall et al.

A1 Journal Article in PLOS ONE

Are the antimicrobial properties of macrolides required for their therapeutic efficacy in chronic neutrophilic airway diseases?

Editorial material

Chronic obstructive pulmonary disease and cerebrovascular disease: a comprehensive review

Lies LahousseHenning TiemeierM Arfan IkramGuy Brusselle

A1 Journal Article in RESPIRATORY MEDICINE

Chronic obstructive pulmonary disease and sudden cardiac death: the Rotterdam study

Lies LahousseMaartje N NiemeijerMarten E van den BergPeter R RijnbeekGuy JoosAlbert HofmanOscar H FrancoJaap W DeckersMark EijgelsheimBruno H Stricker et al.

A1 Journal Article in EUROPEAN HEART JOURNAL

Dysregulated fibulin-5 expression and elastogenesis in COPD lungs: pyromaniac or fire fighter?

Editorial material

Elucidating COPD pathogenesis by large-scale genetic analyses

Guy BrusselleKen Bracke

Editorial material

ERS guidelines, statements and technical standards published in the ERJ in 2014: a year in review

Guy BrusselleMina Gaga

Editorial material

Expression of citrulline and homocitrulline residues in the lungs of non-smokers and smokers : implications for autoimmunity in rheumatoid arthritis

Elena B LugliRaquel ESM CorreiaRoman FischerKarin LundbergKen BrackeAnna B MontgomeryBenedikt M KesslerGuy BrussellePatrick J Venables

A1 Journal Article in ARTHRITIS RESEARCH & THERAPY

Gait patterns in COPD : the Rotterdam Study

Lies LahousseVincentius JA VerlindenJos N van der GeestGuy JoosAlbert HofmanBruno HC StrickerGuy BrusselleM Arfan Ikram

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Identification of differentially expressed microRNAs in neutrophilic asthma

Tania MaesKatleen De PreterFN SchleichM HenketKen BrackeLies LahoussePieter MestdaghGuy JoosGuy BrusselleR Louis

MicroRNA miR-22 drives TH17 responses in emphysema

Guy BrusselleKen Bracke

Editorial material

Molecular mechanisms underlying variations in lung function: a systems genetics analysis

Ma'en ObeidatKe HaoYohan BosséDavid C NickleYunlong NieDirkje S PostmaMichel LavioletteAndrew J SandfordDenise D DaleyJames C Hogg et al.

A1 Journal Article in LANCET RESPIRATORY MEDICINE

Non-coding RNAs and respiratory disease

Pieter MestdaghJo VandesompeleGuy BrusselleKarim Vermaelen

A1 Journal Article in THORAX

Non-coding RNAs in the pathogenesis of COPD

Elise De SmetPieter MestdaghJo VandesompeleGuy BrusselleKen Bracke

A1 Journal Article in THORAX

Prevalence of pulmonary hypertension in the general population : the Rotterdam study

Eduardo M MoreiraHenning GallMaarten JG LeeningLies LahousseDaan W LothBouwe P KrijtheJessica C Kiefte-de JongGuy BrusselleAlbert HofmanBruno H Stricker et al.

A1 Journal Article in PLOS ONE

Real-world research and its importance in respiratory medicine

David PriceGuy BrusselleNicolas RocheDaryl FreemanAlison Chisholm

A2 Journal Article in BREATHE

Reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: results from two multicentre, parallel, double-blind, randomised, placebo-controlled, phase 3 trials

Mario CastroJames ZangrilliMichael E WechslerEric D BatemanGuy BrussellePhilip BardinKevin MurphyJorge F MasperoChristopher O'BrienStephanie Korn

A1 Journal Article in LANCET RESPIRATORY MEDICINE

Risk of a biased assessment of the evidence when limiting literature searches to the English language : macrolides in asthma as an illustrative example

Guy BrusselleFrancesco Blasi

Editorial material

Role of B cell-activating factor in chronic obstructive pulmonary disease

Leen SeysFien VerhammeAnja SchinwaldHamida HammadDanen Mootoosamy CunoosamyClaudie Bantsimba-MalandaAlan SabirshEileen McCallLiz FlavellRonald Herbst et al.

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Role of lymphoid follicles and transforming growth factor (TGF)-β superfamily in the pathogenesis of chronic obstructive pulmonary disease (COPD)

Fien VerhammeGuy BrusselleKen Bracke

Six-minute walk test in systemic sclerosis : systematic review and meta-analysis

Els VandecasteeleMichel De PauwFilip De KeyserSaskia DecumanEllen DeschepperYVES PIETTEGuy BrusselleVanessa Smith

Targeted therapy with inhaled corticosteroids in COPD according to blood eosinophil counts

Guy BrusselleKen BrackeLies Lahousse

Editorial material

The effect of cigarette smoke exposure on the development of inflammation in lungs, gut and joints of TNFΔARE mice

Liesbeth AllaisSmitha KumarKarlijn DebusschereStephanie VERSCHUERETania MaesRebecca De SmetGriet ConickxMartine De VosDebby LaukensGuy Joos et al.

A1 Journal Article in PLOS ONE

The inevitable drift to triple therapy in COPD: an analysis of prescribing pathways in the UK

Guy BrusselleDavid PriceKevin Gruffydd-JonesMarc MiravitllesDorothy L KeiningerRebecca StewartMichael BaldwinRupert C Jones

A1 Journal Article in INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

The Rotterdam Study : 2016 objectives and design update

Albert HofmanGuy BrusselleSarwa Darwish MuradCornelia M van DuijnOscar H FrancoAndré GoedegebureM Arfan IkramCaroline CW KlaverTamar EC NijstenRobin P Peeters et al.

A1 Journal Article in EUROPEAN JOURNAL OF EPIDEMIOLOGY

The Rotterdam study : why fall in COPD?

Lies LahousseVincentius JA VerlindenM Arfan IkramGuy Brusselle

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Transforming growth factor-β superfamily in obstructive lung diseases: more suspects than TGF-β alone

Fien VerhammeKen BrackeGuy JoosGuy Brusselle

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

2014

A practice-based analysis of combinations of diseases in patients aged 65 or older in primary care

Pauline BoeckxstaensWim PeersmanGwendolyn GoubinSouhila GhaliJan De MaeseneerGuy BrusselleAn De Sutter

A1 Journal Article in BMC FAMILY PRACTICE

Accuracy of the Medication Adherence Report Scale (MARS-5) as a quantitative measure of adherence to inhalation medication in patients with COPD

Eline TommeleinEls MehuysInge Van TongelenGuy BrusselleKoen Boussery

A1 Journal Article in ANNALS OF PHARMACOTHERAPY

Adverse outcomes of frailty in the elderly: the Rotterdam study

Lies LahousseBastiaan MaesGijsbertus ZiereDaan W LothVincentius JA VerlindenM Carola ZillikensAndré G UitterlindenFernando RivadeneiraHenning TiemeierOscar H Franco et al.

A1 Journal Article in EUROPEAN JOURNAL OF EPIDEMIOLOGY

Bone mineral density and chronic lung disease mortality: the Rotterdam study

Natalia Campos-ObandoMartha C Castano-BetancourtLing OeiOscar H FrancoBruno HCh StrickerGuy BrusselleLies LahousseAlbert HofmanHenning TiemeierFernando Rivadeneira et al.

A1 Journal Article in JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Cause-specific mortality in mild COPD : the Rotterdam study

Lies LahousseGuy JoosAlbert HofmanBruno StrickerGuy Brusselle

Cigarette smoke exposure alters the development of inflammation in experimental Crohn-like colitis

Liesbeth AllaisStephanie VerscheureKen BrackeRebecca De SmetDebby LaukensClaus BachertMartine De VosGuy BrusselleClaude Cuvelier

Common genes underlying asthma and COPD? : genome-wide analysis on the Dutch hypothesis

Joanna SmolonskaGerard H KoppelmanCisca WijmengaJudith M VonkPieter ZanenMarcel BruinenbergIvan CurjuricMedea ImbodenGian-Andri ThunLude Franke et al.

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Common genetic determinants of lung function, subclinical atherosclerosis and risk of coronary artery disease

Maria Sabater-LlealAners MälarstigLasse FolkersenMaría Soler ArtigasDamiano BaldassarreMaryam KavousiPeter AlmgrenFabrizio VegliaGuy BrusselleAlbert Hofman et al.

A1 Journal Article in PLOS ONE

De doeltreffendheid van farmaceutische zorg bij patiënten met COPD: bespreking van de recent gepubliceerde PHARMACOP-studie

Eline TommeleinEls MehuysT Van HeesEls AdriaensLucas Van BortelThierry ChristiaensInge Van TongelenJean Paul RemonKoen BousseryGuy Brusselle

A4 Journal Article in FARMACEUTISCH TIJDSCHRIFT VOOR BELGIE [1971]

Early origins of chronic obstructive lung diseases across the life course

Liesbeth DuijtsIrwin K ReissGuy BrusselleJohan C de Jongste

A1 Journal Article in EUROPEAN JOURNAL OF EPIDEMIOLOGY

Een 75-jarige vrouw met inspanningsgebonden kortademigheid en desaturatie

Maarten De SmetEline NaertThomas MalfaitGuy BrusselleEric Derom

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Effectiveness of pharmaceutical care for patients with chronic obstructive pulmonary disease ( PHARMACOP): a randomized controlled trial

Eline TommeleinEls MehuysThierry Van HeesEls AdriaensLucas Van BortelThierry ChristiaensInge Van TongelenJean Paul RemonKoen BousseryGuy Brusselle

A1 Journal Article in BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Epidemiology of comorbidities in chronic obstructive pulmonary disease

Lies LahousseGuy BrusselleBH Stricker

Frequent exacerbators: a distinct phenotype of severe asthma

M KupczykA ten BrinkePJ SterkEH BelA PapiP ChanezE Nizankowska-MogilnickaM GjomarkajM GagaGuy Brusselle et al.

A1 Journal Article in CLINICAL AND EXPERIMENTAL ALLERGY

Genome-wide association analysis identifies six new loci associated with forced vital capacity

Daan W LothMaria Soler ArtigasSina A GharibLouise V WainNora FranceschiniBeate KochTess D PottingerAlbert Vernon SmithQing DuanChris Oldmeadow et al.

A1 Journal Article in NATURE GENETICS

Het optimaliseren van de farmacotherapie bij patiënten met chronisch obstructief longlijden (COPD) in de officina-apotheek: een kosten-effectiviteitsanalyse

JFM van BovenEline TommeleinKoen BousseryEls MehuysS VegterGuy BrusselleMPMH Rutten-van MölkenMJ Postma

A4 Journal Article in FARMACEUTISCH TIJDSCHRIFT VOOR BELGIE [1971]

Heterogeneity of phenotypes in severe asthmatics: the Belgian Severe Asthma Registry (BSAR)

F SchleichGuy BrusselleR LouisO VandenplasA MichilsC PiletteR PecheM ManiseGuy Joos

A1 Journal Article in RESPIRATORY MEDICINE

Improving inhaler adherence in patients with Chronic Obstructive Pulmonary Disease : a cost-effectiveness analysis

Job FM van BovenEline TommeleinKoen BousseryEls MehuysStefan VegterGuy BrusselleMaureen PMH Rutten-van MölkenMaarten J Postma

A1 Journal Article in RESPIRATORY RESEARCH

Inflammasomes in respiratory disease: from bench to bedside

Guy BrusselleSharen ProvoostKen BrackeAnna KuchmiyMohamed Lamkanfi

A1 Journal Article in CHEST

Investigation of 5-HT4 receptors in bronchial hyperresponsiveness in cigarette smoke-exposed mice

Lisa DupontKen BrackeJoris H De MaeyerValérie CompanGuy JoosRomain LefebvreGuy Brusselle

A1 Journal Article in PULMONARY PHARMACOLOGY & THERAPEUTICS

Is there a role for macrolides in severe asthma?

Guy BrusselleGuy Joos

A1 Journal Article in CURRENT OPINION IN PULMONARY MEDICINE

Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function

Wenbo TangMatthew KowgierDaan W LothMaría Soler ArtigasBonnie R JoubertEmily HodgeSina A GharibAlbert V SmithIngo RuczinskiVilmundur Gudnason et al.

A1 Journal Article in PLOS ONE

Management of COPD in the UK primary-care setting: an analysis of real-life prescribing patterns

David PriceDaniel WestGuy BrusselleKevin Gruffydd-JonesRupert JonesMarc MiravitllesAndrea RossiCatherine HuttonValerie L AshtonRebecca Stewart et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Mechanistic links between COPD and lung cancer: a role of microRNA let-7?

Jae Il ShinGuy Brusselle

A1 Journal Article in NATURE REVIEWS CANCER

Mepolizumab treatment in patients with severe eosinophilic asthma

Hector G OrtegaMark C LiuIan D PavordGuy BrusselleJ Mark FitzGeraldAlfredo ChettaMarc HumbertLynn E KatzOliver N KeeneSteven W Yancey et al.

A1 Journal Article in NEW ENGLAND JOURNAL OF MEDICINE

Multimorbidity : a quantitative and qualitative exploration in primary care

Pauline BoeckxstaensAn De SutterGuy BrusselleJean-Marie Degryse

Opportunities to diagnose chronic obstructive pulmonary disease in routine care in the UK: a retrospective study of a clinical cohort

Rupert CM JonesDavid PriceDermot RyanErika J SimsJulie von ZiegenweidtLaurence MascarenhasAnne BurdenDavid MG HalpinRobert WinterSue Hill et al.

A1 Journal Article in LANCET RESPIRATORY MEDICINE

Optimalisation de la pharmacothérapie en pharmacie d'officine chez des patients atteints de Bronchopneumopathie Chronique Obstructive (BPCO): une analyse coût-efficacité

JFM van BovenEline TommeleinKoen BousseryEls MehuysS VegterGuy BrusselleMPMH Rutten-van MölkenMJ Postma

A4 Journal Article in JOURNAL DE PHARMACIE DE BELGIQUE

Quality standards for real-world research: focus on observational database studies of comparative effectiveness

Nicolas RocheHelen ReddelRichard MartinGuy BrusselleAlberto PapiMike ThomasDirjke PostmaVicky ThomasCynthia RandAlison Chisholm et al.

A2 Journal Article in ANNALS OF THE AMERICAN THORACIC SOCIETY

Role of activin-A in cigarette smoke-induced inflammation and COPD

Fien VerhammeKen BrackeGimano D AmatngalimGeert M VerledenGeert Van PottelbergePieter S HiemstraGuy JoosGuy Brusselle

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Role of the nitric oxide-soluble guanylyl cyclase pathway in obstructive airway diseases

Lisa DupontConstantinos GlynosKen BrackePeter BrouckaertGuy Brusselle

A1 Journal Article in PULMONARY PHARMACOLOGY & THERAPEUTICS

Role of Transient Receptor Potential Channel A1, serotonin receptor 5-HT4R and soluble guanylyl cyclase in the pathogenesis of chronic obstructive pulmonary disease

Lisa DupontGuy BrusselleGuy Joos

Self-medication in persistent rhinitis: overuse of decongestants in half of the patients

Els MehuysPhilippe GevaertGuy BrusselleThierry Van HeesEls AdriaensThierry ChristiaensLucas Van BortelInge Van TongelenJean Paul RemonKoen Boussery

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY IN PRACTICE

Self-medication in persistent rhinitis: overuse of decongestants in half of the patients

Philippe GevaertEls MehuysGuy BrusselleT Van HeesThierry ChristiaensLucas Van BortelInge Van TongelenJean Paul RemonKoen Boussery

Should we pursue pulmonary vasodilation in patients with COPD?

Editorial material

Stability of phenotypes defined by physiological variables and biomarkers in adults with asthma

M KupczykB DahlenPJ SterkE Nizankowska-MogilnickaA PapiEH BelP ChanezPH HowarthST HolgateGuy Brusselle et al.

A1 Journal Article in ALLERGY

Susceptibility to chronic mucus hypersecretion, a genome wide association study

Akkelies E DijkstraJoanna SmolonskaMaarten van den BergeCiska WijmengaPieter ZanenMarjan A LuingeMathieu PlatteelJan-Willem LammersMagnus DahlbackKerrie Tosh et al.

A1 Journal Article in PLOS ONE

Targeting immune pathways for therapy in asthma and chronic obstructive pulmonary disease

Guy BrusselleKen Bracke

A2 Journal Article in ANNALS OF THE AMERICAN THORACIC SOCIETY

The effect of chronic cigarette smoke exposure on gut microbial diversity in healthy mice

Liesbeth AllaisFrederiek-Maarten KerckhofStephanie VerscheureKen BrackeRebecca De SmetDebby LaukensPieter Van den AbbeeleMartine De VosNico BoonGuy Brusselle et al.

The effect of chronic cigarette smoke exposure on the gut microbiome in healthy mice

Liesbeth AllaisFrederiek-Maarten KerckhofStephanie VerscheureKen BrackeRebecca De SmetDebby LaukensPieter Van den AbbeeleMartine De VosNico BoonGuy Brusselle et al.

Trustworthy guidelines on severe asthma thanks to ERS and ATS

Guy BrusselleMonica Kraft

Editorial material

Usage of inhalation devices in asthma and chronic obstructive pulmonary disease: a Delphi consensus statement

Vincent NinaneGuy BrusselleLouis RenaudLieven DupontGiuseppe LiistroWilfried De BackerMarc SchlesserWalter Vincken

A1 Journal Article in EXPERT OPINION ON DRUG DELIVERY

Use of tiotropium Respimat versus HandiHaler and mortality in patients with COPD

Katia MC VerhammeMiriam CJM SturkenboomGuy Brusselle

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Why doesn't reducing exacerbations decrease COPD mortality?

Editorial material

β-adrenoceptor blockers and pulmonary function in the general population: the Rotterdam Study

Daan W LothGuy BrusselleLies LahousseAlbert HofmanHubert GM LeufkensBruno H Stricker

A1 Journal Article in BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

2013

Azithromycin for prevention of exacerbations in severe asthma (AZISAST): a multicentre randomised double-blind placebo-controlled trial

Guy BrusselleChristine VanderStichelePaul JordensRené DemanHans SlabbynckVeerle RingoetGeert VerledenIngel K DemedtsKatia VerhammeANJA DELPORTE et al.

A1 Journal Article in THORAX

Challenges of COPD diagnosis

David PriceGuy Brusselle

A2 Journal Article in EXPERT OPINION ON MEDICAL DIAGNOSTICS

Chronic cigarette smoke exposure alters the murine gut microbiome

Liesbeth AllaisFrederiek-Maarten KerckhofStephanie VerschuereKen BrackeRebecca De SmetDebby LaukensMartine De VosNico BoonGuy BrusselleTom Van de Wiele et al.

Chronic cigarette smoke exposure alters the murine gut microbiome

Liesbeth AllaisFrederiek-Maarten KerckhofStephanie VerschuereKen BrackeRebecca De SmetDebby LaukensMartine De VosNico BoonGuy BrusselleTom Van de Wiele et al.

Chronic cigarette smoke exposure alters the murine gut microbiome

Liesbeth AllaisFrederiek-Maarten KerckhofStephanie VerscheureKen BrackeRebecca De SmetDebby LaukensMartine De VosNico BoonGuy BrusselleTom Van de Wiele et al.

Chronic obstructive pulmonary disease (COPD) exacerbations and carotid artery plaques : the Rotterdam study

Lies LahousseQuirijn JA van den BouwhuijsenDaan W LothGuy JoosAlbert HofmanJacqueline CM WittemanAad van der LugtGuy BrusselleBruno C Stricker

Chronic obstructive pulmonary disease and cerebral microbleeds: the Rotterdam study

Lies LahousseMeike W VernooijSirwan KL DarweeshSaloua AkoudadDaan W LothGuy JoosAlbert HofmanBruno H StrickerM Arfan IkramGuy Brusselle

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Chronic obstructive pulmonary disease and lipid core carotid artery plaques in the elderly: the Rotterdam Study

Lies LahousseQuirijn JA van den BouwhuijsenDaan W LothGuy JoosAlbert HofmanJacqueline CM WittemanAad van der LugtGuy BrusselleBruno H Stricker

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Contribution of four common pulmonary function tests to diagnosis of patients with respiratory symptoms : a prospective cohort study

Marc DecramerWim JanssensEric DeromGuy JoosVincent NinaneRené DemanDirk Van RenterghemGiuseppe LiistroKris Bogaertsthe Belgian Pulmonary Study Investigators et al.

A1 Journal Article in LANCET RESPIRATORY MEDICINE

COPD awareness survey: do Belgian pulmonary physicians comply with the GOLD guidelines 2010?

M DecramerGuy BrusselleJ BuffelsJL CorhayW De BackerJM DegryseW JanssensE MarchandP Van den BrandeW Vincken et al.

A1 Journal Article in ACTA CLINICA BELGICA

Eosinophilic airway inflammation in nonallergic asthma

Guy BrusselleTania MaesKen Bracke

Editorial material

Exposing a deadly alliance: novel insights into the biological links between COPD and lung cancer

Karim VermaelenGuy Brusselle

A1 Journal Article in PULMONARY PHARMACOLOGY & THERAPEUTICS

Frailty affects quality of spirometry : the Rotterdam study

Lies LahousseDW LothVJA VerlindenG ZiereM ZillikensAG UitterlindenF RivadeneiraH TiemeierM IkramA Hofman et al.

Hand-held fractional exhaled nitric oxide measurements as a non-invasive indicator of systemic inflammation in Crohn's disease

Laure-Ann QuenonPieter HindryckxMartine De VosDanny De LoozeGuy JoosGuy BrusselleHarald Peeters

A1 Journal Article in JOURNAL OF CROHNS & COLITIS

Impact of frailty on interpretability of spirometry : the Rotterdam study

Lies LahousseBastiaan MaesDW LothVJA VerlindenG ZiereMC ZillikensA UitterlindenF RivadeneiraH TiemeierMA Ikram et al.

Integrating real-life studies in the global therapeutic research framework

Nicolas RocheHelen K ReddelAlvar AgustiEric D BatemanJerry A KrishnanRichard J MartinAlberto PapiDirkje PostmaMike ThomasGuy Brusselle et al.

A1 Journal Article in LANCET RESPIRATORY MEDICINE

InternationaL cross-sectIonAl and longItudinal assessment on aSthma cONtrol in European adult patients: the LIAISON study protocol

Fulvio BraidoGuy BrusselleEleonora IngrassiaGabriele NicoliniDavid PriceNicolas RocheJoan B SorianoHeinrich Worth

A1 Journal Article in BMC PULMONARY MEDICINE

Leptin as regulator of pulmonary immune responses: involvement in respiratory diseases

Juanita HJ VernooyNiki DJ UbagsGuy BrusselleJan TavernierBenjamin T SurattGuy JoosEmiel FM WoutersKen Bracke

A1 Journal Article in PULMONARY PHARMACOLOGY & THERAPEUTICS

Long-acting bronchodilators improve Health Related Quality of Life in patients with COPD

Fulvio BraidoIlaria BaiardiniMario CazzolaGuy BrusselleFiorenza MarugoGiorgio Walter Canonica

A1 Journal Article in RESPIRATORY MEDICINE

Normal spirometry values in healthy elderly: the Rotterdam Study

Daan Willem LothTill IttermannLies LahousseAlbert HofmanHubert Gerardus Maria LeufkensGuy BrusselleBruno Hugo Stricker

A1 Journal Article in EUROPEAN JOURNAL OF EPIDEMIOLOGY

Of flies, mice and men : a systematic approach to understanding the early life origins of chronic lung disease

Susanne Krauss-EtschmannAndrew BushSaverio BellusciGuy BrusselleSven Erik K DahlénStefan DehmelOliver EickelbergGreg GibsonMachteld N HylkemaPetra Knaus et al.

A1 Journal Article in THORAX

Omalizumab is effective in allergic and nonallergic patients with nasal polyps and asthma

Philippe GevaertLIEN CALUSThibaut Van ZeleKatrien BlommeNatalie De RuyckWOUTER BAUTERSPeter HellingsGuy BrusselleDirk De BacquerPaul Van Cauwenberge et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Pulmonary function is associated with pulmonary artery systolic pressure in the general population : the Rotterdam study

Daan LothLies LahousseMaarten LeeningBouwe KrijtheJanine FelixHenning TiedeArdeschir GhofraniOscar FrancoBruno StrickerGuy Brusselle

Risk-to-benefit ratio of inhaled corticosteroids in patients with COPD

David PriceBarbara YawnGuy BrusselleAndrea Rossi

A1 Journal Article in PRIMARY CARE RESPIRATORY JOURNAL

Role of CXCL13 in cigarette smoke-induced lymphoid follicle formation and chronic obstructive pulmonary disease

Ken BrackeFien VerhammeLeen SeysClaudie Bantsimba-MalandaDanen Mootoosamy CunoosamyRonald HerbstHamida HammadBart LambrechtGuy JoosGuy Brusselle

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Should clinicians use omalizumab for the treatment of nasal polyps?: reply

LIEN CALUSPeter HellingsGuy BrusselleClaus BachertPhilippe Gevaert

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Spirometric reference values for an East-African population

Sanctus MusafiriJan Van MeerbeeckLaurent MusangoEric DeromGuy BrusselleGuy JoosClaver Rutayisireguy joos

A1 Journal Article in RESPIRATION

Statins, systemic inflammation and risk of death in COPD: the Rotterdam Study

Lies LahousseDaan W LothGuy JoosAlbert HofmanHubert GM LeufkensGuy BrusselleBruno H Stricker

A1 Journal Article in PULMONARY PHARMACOLOGY & THERAPEUTICS

The role of soluble guanylyl cyclase in Chronic Obstructive Pulmonary Disease

Constantinos GlynosLisa DupontTheodoros VassilakopoulosAndreas PapapetropoulosPeter BrouckaertAthanassios GiannisGuy JoosKen BrackeGuy Brusselle

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Use of tiotropium Respimat Soft Mist Inhaler versus HandiHaler and mortality in patients with COPD

Katia MC VerhammeAna AfonsoSilvana RomioBruno C StrickerGuy BrusselleMiriam CJM Sturkenboom

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

2012

Altered cigarette smoke-induced lung inflammation due to ablation of Grx1

Ine KuipersKen BrackeGuy BrusselleScott W AesifRenske KrijgsmanIlja C ArtsEmiel FM WoutersNiki L Reynaert

A1 Journal Article in PLOS ONE

Chronic obstructive pulmonary disease and comorbidities through the eyes of the patient

Pauline BoeckxstaensMarina DeregtPiet VandesypeSara WillemsGuy BrusselleAn De Sutter

A1 Journal Article in CHRONIC RESPIRATORY DISEASE

Chronic rejection pathology after orthotopic lung transplantation in mice : the development of a murine BOS model and its drawbacks

Stephanie De VleeschauwerWolfgang JungraithmayrShana WautersStijn WillemsManuela RinaldiAnnemie VaneylenStijn VerledenAnna Willems-WidyastutiKen BrackeGuy Brusselle et al.

A1 Journal Article in PLOS ONE

Cigarette smoke and the terminal ileum: increased autophagy in murine follicle-associated epithelium and Peyer's patches

Stephanie VERSCHUERELiesbeth AllaisKen BrackeSaskia LippensRebecca De SmetPeter VandenabeeleGuy BrusselleClaude Cuvelier

A1 Journal Article in HISTOCHEMISTRY AND CELL BIOLOGY

COPD is associated with reduced pulmonary interstitial expression of pentraxin-3

Geert Van PottelbergeKen BrackeNele PauwelsFrank VermassenGuy JoosGuy Brusselle

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction

Jemma B WilkNick RG ShrineLaura R LoehrJing Hua ZhaoAni ManichaikulLorna M LopezAlbert Vernon SmithSusan R HeckbertJoanna SmolonskaWenbo Tang et al.

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function

Dana B HancockMaría Soler ArtigasSina A GharibAmanda HenryAni ManichaikulAdaikalavan RamasamyDaan W LothMedea ImbodenBeate KochWendy L McArdle et al.

A1 Journal Article in PLOS GENETICS

I have taken my umbrella, so of course it does not rain

DS PostmaGuy BrusselleA BushJW Holloway

A1 Journal Article in THORAX

Omalizumab is effective in allergic and non-allergic patients with nasal polyps and asthma

Philippe GevaertLIEN CALUSThibaut Van ZeleKatrien BlommeNatalie De RuyckWOUTER BAUTERSP HellingsDirk De BacquerGuy BrussellePaul Van Cauwenberge et al.

Onset of bronchodilation with fluticasone/formoterol combination versus fluticasone/salmeterol in an open-label, randomized study

René AalbersGuy BrusselleTammy McIverBirgit GrotheAnna Bodzenta-Lukaszyk

A1 Journal Article in ADVANCES IN THERAPY

Patient-centred assessment of COPD in primary care: experience from a cross-sectional study of health-related quality of life in Europe

Paul W JonesGuy BrusselleRoberto W Dal NegroMontse FerrerPeter KardosMark L LevyThierry PerezJuan José Soler CataluñaThys van der MolenLukasz Adamek et al.

A1 Journal Article in PRIMARY CARE RESPIRATORY JOURNAL

Real-life effectiveness of extrafine beclometasone dipropionate/formoterol in adults with persistent asthma according to smoking status

Guy BrusselleRudi PechéPaul Van den BrandeAlbert VerhulstWim HollandersJacques Bruhwyler

A1 Journal Article in RESPIRATORY MEDICINE

Risk of cardiac valve regurgitation with dopamine agonist use in Parkinson's disease and hyperprolactinaemia: a multi-country, nested case-control study

Gianluca TrifiròM Mostafa MokhlesJeanne P DielemanEva M van SoestKatia VerhammeGiampiero MazzagliaRon HeringsCynthia de LuiseDouglas RossGuy Brusselle et al.

A1 Journal Article in DRUG SAFETY

Smoke decreases reversible oxidations S-glutathionylation and S-nitrosylation in mice

Ine KuipersKen BrackeGuy BrusselleEmiel F WoutersNiki L Reynaert

A1 Journal Article in FREE RADICAL RESEARCH

Targeting interleukin-4 in asthma : lost in translation?

Tania MaesGuy JoosGuy Brusselle

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The effect of cigarette smoke on mucosal immunity of the terminal ileum

Stephanie VERSCHUEREClaude CuvelierGuy Brusselle

The risk of new onset heart failure associated with dopamine agonist use in Parkinson's disease

M Mostafa MokhlesGianluca TrifiròJeanne P DielemanMendel D HaagEva M van SoestKatia MC VerhammeGiampiero MazzagliaRon HeringsCynthia de LuiseDouglas Ross et al.

A1 Journal Article in PHARMACOLOGICAL RESEARCH

Tiotropium Handihaler and the risk of cardio- or cerebrovascular events and mortality in patients with COPD

KMC VerhammeASM AfonsoC van NoordMD HaagPJ KoudstaalGuy BrusselleMCJM Sturkenboom

A1 Journal Article in PULMONARY PHARMACOLOGY & THERAPEUTICS

2011

Activation of the WNT/β-catenin pathway attenuates experimental emphysema

Nikolaus KneidingerAli Oender YildirimLens CallegariShinji TakenakaMaria Magdalena SteinRio DumitrascuAlexander BohlaKen BrackeRory E MortyGuy Brusselle et al.

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Alternatively activated macrophages and impaired phagocytosis of S-aureus in chronic rhinosinusitis

Olga KryskoGabriële HoltappelsNan ZhangMalgorzata KubicaKim DeswarteLara DeryckeSofie ClaeysHamida HammadGuy BrussellePeter Vandenabeele et al.

A1 Journal Article in ALLERGY

Chronic smoke exposure is associated with autophagy in murine Peyer's patches

Stephanie VERSCHUEREKen BrackeRebecca De SmetLiesbeth AllaisGuy BrusselleClaude Cuvelier

Cigarette smoking alters epithelial apoptosis and immune composition in murine GALT

Stephanie VERSCHUEREKen BrackeTine DemoorMaud PlantingaPhebe VerbruggheLiesbeth FerdinandeBart LambrechtGuy BrusselleClaude Cuvelier

A1 Journal Article in LABORATORY INVESTIGATION

Cigarette smoking alters intestinal barrier function and Peyer's Patch composition

Stephanie VERSCHUEREKen BrackeTine DemoorMaud PlantingaBart LambrechtGuy BrusselleClaude Cuvelier

COPD in the general population: prevalence, incidence and survival

Ana SM AfonsoKatia MC VerhammeMiriam CJM SturkenboomGuy Brusselle

A1 Journal Article in RESPIRATORY MEDICINE

Effect of different asthma treatments on risk of cold-related exacerbations

HK ReddelC JenkinsS QuirceMR SearsED BatemanPM O'ByrneM HumbertR BuhlT HarrisonGuy Brusselle et al.

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Exacerbation of cigarette smoke-induced pulmonary inflammation by Staphylococcus aureus enterotoxin B in mice

Wouter HuvenneEllen LanckackerOlga KryskoKen BrackeTine DemoorPeter W HellingsGuy BrusselleGuy JoosClaus BachertTania Maes

A1 Journal Article in RESPIRATORY RESEARCH

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

Maria Soler ArtigasDaan W LothLouise V WainSina A GharibMa'en ObeidatWenbo TangGuangju ZhaiJing Hua ZhaoAlbert Vernon SmithJennifer E Huffman et al.

A1 Journal Article in NATURE GENETICS

Health-related quality of life in patients by COPD severity within primary care in Europe

PW JonesGuy BrusselleRW Dal NegroM FerrerP KardosML LevyT PerezJJ Soler-CatalunaT van der MolenL Adamek et al.

A1 Journal Article in RESPIRATORY MEDICINE

Inhaled anticholinergic drugs and risk of acute urinary retention

Ana SM AfonsoKatia MC VerhammeBruno HC StrickerMiriam CJM SturkenboomGuy Brusselle

A1 Journal Article in BJU INTERNATIONAL

Interleukin 6 (IL6) plasma levels, common variation In the IL6 gene and the risk of chronic obstructive pulmonary disease : a prospective population-based cohort study

Lies LahousseYANNICK VAN DURMEKMC VerhammeL StolkM EijgelsheimD LothAG UitterlindenM BretelerGuy JoosA Hofman et al.

Mendelian randomization study of interleukin-6 in chronic obstructive pulmonary disease

YANNICK VAN DURMELies LahousseKatia MC VerhammeLisette StolkMark EijgelsheimDaan W LothAndre G UitterlindenMonique MB BretelerGuy JoosAlbert Hofman et al.

A1 Journal Article in RESPIRATION

MicroRNA expression in induced sputum of smokers and patients with chronic obstructive pulmonary disease

Geert Van PottelbergePieter MestdaghKen BrackeOlivier ThasYANNICK VAN DURMEGuy JoosJo VandesompeleGuy Brusselle

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Microscopic polyangiitis involving the breast

MIEKE DEVINCKBert Vander CruyssenKathleen LambeinFilip De KeyserMarleen PraetGuy Brusselle

A1 Journal Article in ACTA CLINICA BELGICA

Neomacrolides in the treatment of patients with severe asthma and/or bronchiectasis : a retrospective observational study

Mathieu CoemanYANNICK VAN DURMEFre BautersEllen DeschepperIngel DemedtsPeter SmeetsGuy JoosGuy Brusselle

A2 Journal Article in THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE

New insights into the immunology of chronic obstructive pulmonary disease

Guy BrusselleGuy JoosKen Bracke

A1 Journal Article in LANCET

Prevalence of atopy, asthma and COPD in an urban and a rural area of an African country

Sanctus MusafiriJan Van MeerbeeckLaurent MusangoGuy BrusselleGuy JoosBenoit SeminegaClaver Rutayisire

A1 Journal Article in RESPIRATORY MEDICINE

Properties of the COPD assessment test in a cross-sectional European study

PW JonesGuy BrusselleRW Dal NegroM FerrerP KardosML LevyeT PerezJJ Soler CataluñaT van der MolenL Adamek et al.

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Role of IL-1α and the Nlrp3/caspase-1/IL-1β axis in cigarette smoke-induced pulmonary inflammation and COPD

NS PauwelsKen BrackeLisa DupontGeert Van PottelbergeSharen ProvoostTom Vanden BerghePeter VandenabeeleBart LambrechtGuy JoosGuy Brusselle

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

The role of ChemR23 in the induction and resolution of cigarette smoke-induced inflammation

Tine DemoorKen BrackeLisa DupontMaud PlantingaBenjamin BondueMarie-Odile RoyVincent LannoyBart LambrechtGuy BrusselleGuy Joos

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Viruses and bacteria in acute asthma exacerbations : a GA2LEN-DARE* systematic review

NG PapadopoulosI ChristodoulouG RohdeI AgacheC AlmqvistA BrunoS BoniniL BontA BossiosJ Bousquet et al.

A1 Journal Article in ALLERGY

2010

A 41-year-old man with breast cancer and dyspnoea: an exceptional complication in an uncommon disease

VERONIQUE BUYSEGuy BrusselleVeronique CocquytSimon Van Belle

A1 Journal Article in ACTA CLINICA BELGICA

Behandeling van COPD : waar ligt de rol van de officina-apotheker?

Els MehuysKoen BousseryEls AdriaensLucas Van BortelLeen De BolleInge Van TongelenJean Paul RemonGuy Brusselle

A4 Journal Article in FARMACEUTISCH TIJDSCHRIFT VOOR BELGIE [1971]

Chronic cough in upper airway diseases

Jean-Baptiste WateletThibaut Van ZeleGuy Brusselle

A1 Journal Article in RESPIRATORY MEDICINE

Cigarette smoke induces PTX3 expression in pulmonary veins of mice in an IL-1 dependent manner

Nele PauwelsKen BrackeTania MaesGeert Van PottelbergeCecilia GarlandaAlberto MantovaniGuy JoosGuy Brusselle

A1 Journal Article in RESPIRATORY RESEARCH

COPD management in primary care : an observational, community pharmacy-based study

Els MehuysKoen BousseryEls AdriaensLucas Van BortelLeen De BolleInge Van TongelenJean Paul RemonGuy Brusselle

COPD management in primary care: an observational, community pharmacy-based study

Els MehuysKoen BousseryEls AdriaensLucas Van BortelLeen De BolleInge Van TongelenJean Paul RemonGuy Brusselle

A1 Journal Article in ANNALS OF PHARMACOTHERAPY

Different regulation of cigarette smoke induced inflammation in upper versus lower airways

Wouter HuvenneClaudina Perez NovoLara DeryckeNatalie De RuyckOlga KryskoTania MaesNele PauwelsLander RobaysKen BrackeGuy Joos et al.

A1 Journal Article in RESPIRATORY RESEARCH

Enhanced deposition of low-molecular-weight hyaluronan in lungs of cigarette smoke-exposed mice

Ken BrackeMieke A DentenerEleni PapakonstantinouJuhanita HJ VernooyTine DemoorNele PauwelsJack CleutjensRobert Jan van SuylenGuy JoosGuy Brusselle et al.

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

GINA en GOLD, een update

An SimpelaereEric DeromGuy BrusselleGuy Joos

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Hedgehog-interacting protein is a COPD susceptibility gene: the Rotterdam Study

YANNICK VAN DURMEM EijgelsheimGuy JoosA HofmanAG UitterlindenGuy BrusselleBHC Stricker

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Increased T-regulatory cells in lungs and draining lymph nodes in a murine model of COPD

Tine DemoorKen BrackeGuy JoosGuy Brusselle

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Leptin modulates innate and adaptive immune cell recruitment after cigarette smoke exposure in mice

JHJ VernooyKen BrackeNEA DrummenNSA PauwelsLennart ZabeauRJ van SuylenJan TavernierGuy JoosEFM WoutersGuy Brusselle

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function

Dana B HancockMark EijgelsheimJemma B WilkSina A GharibLaura R LoehrKristin D MarcianteNora FranceschiniYANNICK VAN DURMETing-Hsu ChenR Graham Barr et al.

A1 Journal Article in NATURE GENETICS

Plasmacytoid dendritic cells in pulmonary lymphoid follicles of patients with COPD

Geert Van PottelbergeKen BrackeSarah Van den BroeckSuzanne M ReinartzCornelis M van DrunenEmiel FM WoutersGeert M VerledenFrank VermassenGuy JoosGuy Brusselle

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Plasmacytoid dendritic cells in pulmonary lymphoid follicles of patients with COPD

Geert Van PottelbergeKen BrackeSarah Van den BroeckSuzanne ReinartzCornelis M van DrunenEmiel FM WoutersGeert M VerledenFrank VermassenGuy JoosGuy Brusselle

Reduced expression of pentraxin-3 in the lungs of patients with COPD

Geert Van PottelbergeKen BrackeN PauwelsYANNICK VAN DURMEGM VerledenFrank VermassenGuy JoosGuy Brusselle

Rheumatoid arthritis and interstitial lung disease

Editorial material

Selective accumulation of Langerhans-type dendritic cells in small airways of patients with COPD

Geert Van PottelbergeKen BrackeIngel DemedtsKim De RijckSuzanne ReinartzCornelis van DrunenGeert VerledenFrank VermassenGuy JoosGuy Brusselle

A1 Journal Article in RESPIRATORY RESEARCH

The role of interleukin-6 in pulmonary and systemic manifestations in a murine model of chronic obstructive pulmonary disease

Nele PauwelsKen BrackeTania MaesCharles PiletteGuy JoosGuy Brusselle

A1 Journal Article in EXPERIMENTAL LUNG RESEARCH

2009

"Real-life" effectiveness of omalizumab in patients with severe persistent allergic asthma: The PERSIST study

Guy BrusselleA MichilsR LouisL DupontBV de MaeleA DelobbeC PiletteCS LeeS GurdainS Vancayzeele et al.

A1 Journal Article in RESPIRATORY MEDICINE

C-reactive protein levels, haplotypes and the risk of incident chronic obstructive pulmonary disease

YANNICK VAN DURMEKatia VerhammeAlbert-Jan AarnoudseGeert Van PottelbergeAlbert HofmanJacqueline WittemanGuy JoosGuy BrusselleBruno Stricker

A1 Journal Article in American Journal of Respiratory Critical Care Medicine

CCR7 Modulates Pulmonary and Lymph Node Inflammatory Responses in Cigarette Smoke-Exposed Mice

Tine DemoorKen BrackeKarim VermaelenLisa DupontGuy JoosGuy Brusselle

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Cigarette smoke induces apoptosis in the follicle-associated epithelium of murine Peyer's patches

Stephanie VERSCHUEREPhilip VlummensPhebe VerbruggheKen BrackeIsabelle RottiersGuy BrusselleClaude Cuvelier

Concomittant inhalation of cigarette smoke and aerosolized protein activates airway dendritic cells and induces allergic airway inflammation in a TLR-independent way

Lander RobaysEllen LanckackerKatrien MoerlooseTania MaesKen BrackeGuy BrusselleGuy JoosKarim Vermaelen

A1 Journal Article in Journal of Immunology

Decreased FOXP3 protein expression in patients with asthma

Sharen ProvoostTania MaesYANNICK VAN DURMEPhilippe GevaertClaus BachertC.B. Schmidt-WeberGuy BrusselleGuy JoosKurt Tournoy

A1 Journal Article in Allergy

Different regulation of cigarette smoke induced inflammation in upper versus lower airways: findings from a mouse model

Wouter HuvenneClaudina Perez NovoNatalie De RuyckNele PauwelsLander RobaysTania MaesPaul Van CauwenbergeGuy JoosGuy BrusselleClaus Bachert

Enhanced pulmonary leptin expression in patients with severe COPD and asymptomatic smokers

JHJ VernooyNEA DrummenRJ Van SuylenRHE ClootsGM MollerKen BrackeS ZuyderduynMA DentenerGuy BrussellePS Hiemstra et al.

A1 Journal Article in Thorax

Extrapulmonary manifestations of chronic obstructive pulmonary disease in a mouse model of chronic cigarette smoke exposure

Ken BrackeGuy JoosGuy Brusselle

A1 Journal Article in American Journal of Respiratory Cell and Molecular Biology

Lymphoid follicles in (very) severe COPD: beneficial or harmful?

Guy BrusselleTine DemoorKen BrackeC.-A. BrandsmaW. Timens

A1 Journal Article in European Respiratory Journal

Matrix Metalloproteinase 12, Asthma, and COPD

Editorial material

Prevalence, incidence and lifetime risk for the development of COPD in the elderly : the Rotterdam study

YANNICK VAN DURMEKatia VerhammeTheo StijnenFrank Van RooijGeert Van PottelbergeAlbert HofmanGuy JoosBruno StrickerGuy Brusselle

A1 Journal Article in CHEST

Role of Lymphotoxin (alpha) in Cigarette Smoke-Induced Inflammation and Lymphoid Neogenesis

Tine DemoorKen BrackeTania MaesBERNARD VANDOORENDirk ElewautCharles PiletteGuy JoosGuy Brusselle

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Role of tachykinin NK1 receptor in a murine model of cigarette-smoke induced pulmonary inflammation

Katelijne De SwertKen BrackeTine DemoorGuy BrusselleGuy Joos

A1 Journal Article in Respiratory Research

The Role of Dendritic Cells in the Pathogenesis of COPD: Liaison Officers in the Front Line

Geert Van PottelbergeKen BrackeGuy JoosGuy Brusselle

A1 Journal Article in COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

2008

Comment on "cigarette smoke-induced pulmonary inflammation is TLR4/MyD88 and IL-1R1/MyD88 signaling dependent"

Tania MaesKen BrackeGuy JoosGuy Brusselle

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Dendritic cells in chronic obstructive pulmonary disease - New players in an old game

M TSOUMAKIDOUINGEL DEMEDTSGuy BrussellePK JEFFERY

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Effectiveness of pharmacist intervention for asthma control improvement

Els MehuysLucas Van BortelLeen De BolleInge Van TongelenLieven AnnemansJean Paul RemonGuy Brusselle

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Inhaled anticholinergic drugs and risk of acute urinary retention

ASM AFONSOKMC VERHAMMEBC STRICKERGuy BrusselleMCJM STURKENBOOM

Outpatient Pharmacotherapy

Bookchapter in Pharmacotherapy of Asthma

Pharmacist interventions in asthma - Reply

E MEHUYSGuy Brusselle

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

TNF alpha receptor genotype influences smoking-induced muscle-fibre-type shift and atrophy in mice

Boel De PaepeGuy BrusselleTania MaesKim CreusSophie D'hoseNele D'HaeseKen BrackeAn D'hulstGuy JoosJan De Bleecker

A1 Journal Article in ACTA NEUROPATHOLOGICA

2007

Accumulation of dendritic cells and increased CCL20 levels in the airways of patients with chronic obstructive pulmonary disease

Ingel DemedtsKen BrackeGeert Van PottelbergeDries TestelmansGeert M VerledenFrank VermassenGuy JoosGuy Brusselle

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Bilateral spontaneous pneumothorax in a patient with pulmonary rheumatoid nodules, secondary infected by Aspergillus

L WINNEMarleen PraetGuy BrusselleEric VeysHerman Mielants

A1 Journal Article in CLINICAL RHEUMATOLOGY

Chemokine receptor CCR2 but not CCR5 or CCR6 mediates the increase in pulmonary dendritic cells during allergic airway inflammation.

Lander RobaysTania MaesS LEBECQUESA LIRAWA KUZIELGuy BrusselleGuy JoosKarim Vermaelen

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Cigarette smoke-induced pulmonary inflammation, but not airway remodelling, is attenuated in chemokine receptor 5-deficient mice

Ken BrackeAn D'hulstTania MaesINGEL DEMEDTSKatrien MoerlooseWA KUZIELGuy JoosGuy Brusselle

A1 Journal Article in CLINICAL AND EXPERIMENTAL ALLERGY

Dendritic cell maturity and obstructive airway disease

Ingel DemedtsGuy JoosGuy Brusselle

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Interstitiële longafwijkingen bij reumatoide artritis

E VAN SCHOOTEL VANWALLEGHEMF DE KEYSERGuy JoosGuy Brusselle

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Mechanisms of virus-induced asthma exacerbations: state-of-the-art. A GA(2)LEN and InterAirways document

NG PAPADOPOULOSP XEPAPADAKIP MALLIAGuy BrusselleJean-Baptiste WateletM XATZIPSALTIG FOTEINOSCM VAN DRUNENWJ FOKKENSC D'AMBROSIO et al.

A1 Journal Article in ALLERGY

Pulmonary dendritic cells: playing ball in the BAL?

IK DEMEDTSGuy JoosGuy Brusselle

Editorial material

Pulmonary-renal syndromes

A1 Journal Article in ACTA CLINICA BELGICA

Re: Pulmonary arterial hypertension in connective tissue diseases

Vanessa SmithMichel De PauwGuy BrusselleJens Van PraetFilip De Keyser

A1 Journal Article in RHEUMATOLOGY

Role of dendritic cells and matrix metalloproteinase-12 in the pathogenesis of COPD

Ingel DemedtsGuy BrusselleGuy JoosRomain Pauwels

Sporen wij astmapatiënten aan tot zelfzorg? : een enquête bij Vlaamse huisartsen en pneumologen : brief aan de redactie

Els MehuysLucas Van BortelGuy Brusselle

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Systeemsclerose

Vanessa SmithGuy BrusselleMichel De PauwDaniël De Wolf

A2 Journal Article in Tijdschrift voor Geneeskunde

TNF alpha receptor signalling influences the expression of myosin heavy chain isoforms in musculus gastrocnemius of the mouse

Boel De PaepeKim CreusSophie D'hoseGuy BrusselleJan De Bleecker

2006

Animal models of allergen-induced tolerance in asthma: are T-regulatory-1 cells (Tr-1) the solution for T-helper-2 cells (Th-2) in asthma?

Kurt TournoyChris Van HoveJohan GrootenK MOERLOOSEGuy BrusselleGuy Joos

A1 Journal Article in CLINICAL AND EXPERIMENTAL ALLERGY

Cigarette smoke exposure facilitates allergic sensitization in mice

Katrien MoerlooseLander RobaysTania MaesGuy BrusselleKurt TournoyGuy Joos

A1 Journal Article in RESPIRATORY RESEARCH

Cigarette smoke-induced pulmonary inflammation and emphysema are attenuated in CCR6-deficient mice

Ken BrackeAn D'hulstTania MaesKatrien MoerlooseIngel DemedtsS LEBECQUEGuy JoosGuy Brusselle

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Corticosteroids and the risk of atrial fibrillation

CS VAN DER HOOFTJ HEERINGAGuy BrusselleA HOFMANJCM WITTEMANJH KINGMAMCJM STURKENBOOMBHC STRICKER

A1 Journal Article in ARCHIVES OF INTERNAL MEDICINE

Different roles for human lung dendritic cell subsets in pulmonary immune defense mechanisms

Ingel DemedtsKen BrackeTania MaesGuy JoosGuy Brusselle

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Elevated MMP-12 protein levels in induced sputum from patients with COPD

IK DEMEDTSA MOREL-MONTEROS LEBECQUEY PACHECOD CATALDOGuy JoosRomain PauwelsGuy Brusselle

A1 Journal Article in THORAX

Medication use and disease control of asthmatic patients in Flanders: A cross-sectional community pharmacy study

Els MehuysLucas Van BortelLieven AnnemansJean Paul RemonInge Van TongelenE VAN GANSEL LAFORESTG CHAMBAGuy Brusselle

A1 Journal Article in RESPIRATORY MEDICINE

Murine models of COPD

Guy BrusselleKen BrackeTania MaesAn D'hulstKatrien MoerlooseGuy JoosRomain Pauwels

A1 Journal Article in PULMONARY PHARMACOLOGY & THERAPEUTICS

Murine TLR4 is implicated in cigarette smoke-induced pulmonary inflammation

Tania MaesKen BrackeKarim VermaelenIngel DemedtsGuy JoosRomain PauwelsGuy Brusselle

A1 Journal Article in INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Mycobacterium avium complex with a distinct clinical and iconographic presentation: The lady Windermere syndrome

H GOEMINNERenaat PelemanGuy BrusselleKurt Tournoy

A1 Journal Article in ACTA CLINICA BELGICA

Observational study on respiratory symptoms and household cleaning activities in female workers

Inge GevaertPhilippe KissMarc De MeesterGuy Brusselle

Role of apoptosis in the pathogenesis of COPD and pulmonary emphysema

Ingel DemedtsTine DemoorKen BrackeGuy JoosGuy Brusselle

A1 Journal Article in RESPIRATORY RESEARCH

Role of tumour necrosis factor-alpha receptor p75 in cigarette smoke-induced pulmonary inflammation and emphysema

An D'hulstKen BrackeTania MaesJan De BleeckerRomain PauwelsGuy JoosGuy Brusselle

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

2005

Cigarette smoke-induced pulmonary emphysema in scid-mice. Is the acquired immune system required?

An D'hulstTania MaesKen BrackeIngel DemedtsKurt TournoyGuy JoosGuy Brusselle

A1 Journal Article in RESPIRATORY RESEARCH

De vuurspuwerslong: een bijzondere casus van aspiratiepneumonitis

Fre BautersKurt TournoyRobert GosselinGuy BrusselleGuy Joos

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Identification and characterization of human pulmonary dendritic cells

Ingel DemedtsGuy BrusselleKarim VermaelenRomain Pauwels

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Matrix metalloproteinase-12 and cathepsin D expression in pulmonary macrophages and dendritic cells of cigarette smoke-exposed mice

Ken BrackeD CATALDOTania MaesM GUEDERSA NOELJM FOIDARTGuy BrusselleRomain Pauwels

A1 Journal Article in INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Matrix metalloproteinases in asthma and COPD

Ingel DemedtsGuy BrusselleKen BrackeKarim VermaelenRomain Pauwels

A1 Journal Article in CURRENT OPINION IN PHARMACOLOGY

Positioning of glucocorticosteroids in asthma and allergic rhinitis guidelines (versus other therapies)

Guy JoosGuy BrusselleHelen Van HoeckePaul Van CauwenbergeJean BousquetRomain A Pauwels

A1 Journal Article in IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

Time course of cigarette smoke-induced pulmonary inflammation in mice

AI D'HULSTKY VERMAELENGuy BrusselleGuy JoosRomain Pauwels

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

2003

Tiotropium bromide : a long-acting anticholinergic bronchodilator for the treatment of patients with chronic obstructive pulmonary disease

Guy JoosGuy BrusselleEric DeromRomain Pauwels

A1 Journal Article in INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

2000

Interleukin 5 regulates the isoform expression of its own receptor alpha-subunit.

Jan TavernierJ VAN DER HEYDENA VERHEEGuy BrusselleXaveer Van OstadeJoël VandekerckhoveJ NORTHSM RANKINAB KAYDS ROBINSON

A1 Journal Article in BLOOD

1998

Cytokines and their receptors as therapeutic targets in asthma

Romain PauwelsGuy BrusselleKurt TournoyBart LambrechtJohan Kips

A1 Journal Article in CLINICAL AND EXPERIMENTAL ALLERGY

1997

Cytokine manipulation in animal models of asthma.

Romain PauwelsGuy BrusselleJohan Kips

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Role of IFN-gamma in the inhibition of the allergic airway inflammation caused by IL-12.

Guy BrusselleJohan KipsRenaat PelemanGuy JoosRR DEVOSJan TavernierRomain Pauwels

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Serum neuron-specific enolase as a tumor marker in the diagnosis and follow-up of small-cell lung cancer.

Philippe PinsonGuy JoosPatrick WatripontGuy BrusselleRomain Pauwels

A1 Journal Article in RESPIRATION

1996

Interleukin-12 inhibits antigen-induced airway hyperresponsiveness in mice.

Johan KipsGuy BrusselleGuy JoosRenaat PelemanJan TavernierRR DEVOSRomain Pauwels

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

1995

Allergen-induced airway inflammation and bronchial responsiveness in wild-type and interleukin-4-defïcient mice.

Guy BrusselleJohan KipsGuy JoosH BLUETHMANNRomain Pauwels

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Importance of interleukin-4 and interleukin-12 in allergen-induced airway changes in mice.

Johan KipsGuy BrusselleGuy JoosRenaat PelemanRR DEVOSJan TavernierRomain Pauwels

A1 Journal Article in INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Inhibition of the allergen induced eosinophil influx in murine airways by EL-12 is not mediated through IFN-gamma

J KIPSGuy BrusselleRenaat PelemanGuy JoosRomain Pauwels

A2 Journal Article in American Journal Resp. Critical Care Medicine, 151, A826, 1 tab

1994

An in vivo mouse model of allergic airway inflammation and airway hyperresponsiveness

Guy BrusselleJ KIPSRenaat PelemanGuy JoosRomain Pauwels

A2 Journal Article in American Journal Resp. Crit. Care Med., 149, nr. 4, p. A754, 1 tab

ATTENUATION OF ALLERGIC AIRWAY INFLAMMATION IN IL-4 DEFICIENT MICE.

Guy BrusselleJohan KipsJan TavernierJG VANDERHEYDENClaude CuvelierRomain PauwelsH BLUETHMANN

A1 Journal Article in CLINICAL AND EXPERIMENTAL ALLERGY

Immune responses in Interleukin 4-deficient mice

Guy BrusselleGLE GrosG KohlerN SchultzeP KöbelJohan KipsRomain PauwelsH Blüthmann

Bookchapter in Transgenesis and targeted mutagenesis for immune system analysis

Interleukin-12 inhibits allergen induced airway inflammation and hyperresponsiveness in mice

Johan KipsGuy BrusselleRenaat PelemanGuy JoosJ TAVERNIERM GATELYRomain Pauwels

A2 Journal Article in American Journal Resp. Crit. Care Med., New York, 149, nr. 4, p. A754, 1 tab

1992

Organization and chromosomal localization of the human interleukin 5 receptor cc-chain gene

T TuypensG PlaetinckE BakerG SutherlandGuy BrusselleWalter FiersR DevosJan Tavernier

A2 Journal Article in EUROPEAN CYTOKINE NETWORK