Research Explorer

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Researcher

Griet Van Imschoot

Publications & Research Data

Awards & Distinctions

33 Results

2025

Gut microbiota modulates CNS barrier function in murine model for multiple sclerosis

Junhua XieMarlies BurgelmanPieter DujardinJonas CasteleinGriet Van ImschootElien Van WonterghemHannah LernoutSjoerd SchettersCharysse VandendriesscheLien Van Hoecke et al.

U Journal Article in FLUIDS AND BARRIERS OF THE CNS

The gut-brain axis in Alzheimer's disease is shaped by commensal gut microbiota derived extracellular vesicles

Junhua XieLien Van HoeckeElien Van WonterghemGriet Van ImschootVanessa AndriesLars VereeckeRoosmarijn Vandenbroucke

A1 Journal Article in GUT MICROBES

2024

An immunological puzzle : the adaptive immune system fuels Alzheimer’s disease pathology

Lien Van HoeckeJonas CasteleinJunhua XieLore Van AckerGriet Van ImschootElien Van WonterghemIne VlaeminckDaan VerhaegeWouter ClaeysKeimpe Wierda et al.

A1 Journal Article in BRAIN BEHAVIOR AND IMMUNITY

Challenging the conventional wisdom : re-evaluating smpd3's role in extracellular vesicle biogenesis

Marlies BurgelmanPieter DujardinAnthony WillemsTino HochepiedGriet Van ImschootElien Van WonterghemLien Van HoeckeCharysse VandendriesscheRoosmarijn Vandenbroucke

A2 Journal Article in JOURNAL OF EXTRACELLULAR BIOLOGY

The spreading and effects of human recombinant α-synuclein preformed fibrils in the cerebrospinal fluid of mice

Charysse VandendriesscheArnout BruggemanJoyce ForoozandehLien Van HoeckePieter DujardinJunhua XieGriet Van ImschootElien Van WonterghemJonas CasteleinCristiano Lucci et al.

A1 Journal Article in ENEURO

2023

Experimental hepatic encephalopathy causes early but sustained glial transcriptional changes

Wouter ClaeysLien Van HoeckeHannah LernoutClint De NolfGriet Van ImschootElien Van WonterghemDaan VerhaegeJonas CasteleinAnja GeertsChristophe Van Steenkiste et al.

A1 Journal Article in JOURNAL OF NEUROINFLAMMATION

Gut microbiota regulates blood-cerebrospinal fluid barrier function and Aβ pathology

Junhua XieArnout BruggemanClint De NolfCharysse VandendriesscheGriet Van ImschootElien Van WonterghemLars VereeckeRoosmarijn Vandenbroucke

A1 Journal Article in EMBO JOURNAL

Helicobacter pylori-derived outer membrane vesicles contribute to Alzheimer's disease pathogenesis via C3-C3aR signalling

Junhua XieLien CoolsGriet Van ImschootElien Van WonterghemMarie PauwelsIne VlaeminckChloë De WitteSamir EL AndaloussiKeimpe WierdaLies De Groef et al.

A1 Journal Article in JOURNAL OF EXTRACELLULAR VESICLES

Limitations of PLX3397 as a microglial investigational tool : peripheral and off-target effects dictate the response to inflammation

Wouter ClaeysDaan VerhaegeGriet Van ImschootElien Van WonterghemLore Van AckerLaura AmelinckFederico Francesco De PontiCharlotte ScottAnja GeertsChristophe Van Steenkiste et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

2022

A mouse model of hepatic encephalopathy : bile duct ligation induces brain ammonia overload, glial cell activation and neuroinflammation.

Wouter ClaeysLien Van HoeckeAnja GeertsHans Van VlierbergheSander LefereGriet Van ImschootElien Van WonterghemBart GhesquièreRoosmarijn VandenbrouckeChristophe Van Steenkiste

A1 Journal Article in SCIENTIFIC REPORTS

Choroid plexus-derived extracellular vesicles exhibit brain targeting characteristics

Marie PauwelsJunhua XieAdam CeroiSriram BalusuJonas CasteleinElien Van WonterghemGriet Van ImschootAndrew WardTrevelyan R. MenheniottOskar Gustafsson et al.

A1 Journal Article in BIOMATERIALS

Microdissection and whole mount scanning electron microscopy visualization of mouse choroid plexus

Elien Van WonterghemLien Van HoeckeGriet Van ImschootDaan VerhaegeMarlies BurgelmanRoosmarijn Vandenbroucke

A1 Journal Article in JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

Neurometabolic and gliovascular changes in murine hepatic encephalopathy

Wouter ClaeysLien Van HoeckeAnja GeertsHans Van VlierbergheXavier VerhelstSander LefereHelena DegrooteGriet Van ImschootElien Van WonterghemRoosmarijn Vandenbroucke et al.

2021

Anti-inflammatory mesenchymal stromal cell-derived extracellular vesicles improve pathology in Niemann-Pick type C disease

Lien Van HoeckeCaroline Van CauwenbergheVerena BoergerArnout BruggemanJonas CasteleinGriet Van ImschootElien Van WonterghemRobin DittrichWouter ClaeysJunhua Xie et al.

A1 Journal Article in BIOMEDICINES

Gastric Helicobacter suis infection partially protects against neurotoxicity in A 6-OHDA Parkinson’s disease mouse model

Helena BerlamontArnout BruggemanEva BauwensCharysse VandendriesscheElien ClareboutJunhua XieSofie De BruyckereGriet Van ImschootElien Van WonterghemRichard Ducatelle et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Importance of extracellular vesicle secretion at the blood-cerebrospinal fluid interface in the pathogenesis of Alzheimer’s disease

Charysse VandendriesscheSriram BalusuCaroline Van CauwenbergheMarjana BrkićMarie PauwelsNele PlehiersArnout BruggemanPieter DujardinGriet Van ImschootElien Van Wonterghem et al.

A1 Journal Article in ACTA NEUROPATHOLOGICA COMMUNICATIONS

Involvement of the choroid plexus in the pathogenesis of Niemann-Pick disease type C

Lien Van HoeckeCaroline Van CauwenbergheKristina DominkoGriet Van ImschootElien Van WonterghemJonas CasteleinJunhua XieWouter ClaeysCharysse VandendriesscheAnna Kremer et al.

A1 Journal Article in FRONTIERS IN CELLULAR NEUROSCIENCE

Low-grade peripheral inflammation affects brain pathology in the App(NL-G-F)mouse model of Alzheimer's disease

Junhua XieNina GorléCharysse VandendriesscheGriet Van ImschootElien Van WonterghemCaroline Van CauwenbergheEef ParthoensEvelien Van HammeSaskia LippensLien Van Hoecke et al.

A1 Journal Article in ACTA NEUROPATHOLOGICA COMMUNICATIONS

2020

A murine model of hepatic encephalopathy : validation and neurobehavioral testing

Wouter ClaeysAnja GeertsSander LefereHans Van VlierbergheGriet Van ImschootElien Van WonterghemRoosmarijn VandenbrouckeChristophe Van Steenkiste

2018

A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation

Sofie VoetConor Mc GuireNora HagemeyerArne MartensAnna SchroederPeter WieghoferCarmen DaemsOri StaszewskiLieselotte Vande WalleMarta Joana Costa Jordao et al.

A1 Journal Article in NATURE COMMUNICATIONS

Counteracting the effects of TNF receptor-1 has therapeutic potential in Alzheimer's disease

Sophie SteelandNina GorléCharysse VandendriesscheSriram BalusuMarjana BrkićCaroline Van CauwenbergheGriet Van ImschootElien Van WonterghemRiet De RyckeAnna Kremer et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

Quantifying the average number of nucleic acid therapeutics per nanocarrier by single particle tracking microscopy

Elisa ZagatoLotte VermeulenHeleen DewitteGriet Van ImschootRoosmarijn VandenbrouckeJo DemeesterStefaan De SmedtKristiaan NeytsKatrien RemautKevin Braeckmans

A1 Journal Article in MOLECULAR PHARMACEUTICS

The choroid plexus epithelium as a novel player in the stomach-brain axis during Helicobacter infection

Nina GorléCaroline BlaecherEva BauwensCharysse VandendriesscheSriram BalusuJolien VandewalleCaroline Van CauwenbergheElien Van WonterghemGriet Van ImschootCheng Liu et al.

A1 Journal Article in BRAIN BEHAVIOR AND IMMUNITY

2017

Caspase-9 has a nonapoptotic function in Xenopus embryonic primitive blood formation

Hong Tran ThiMathias FransenDionysia DimitrakopoulouGriet Van ImschootNicolas WillemarckKris Vleminckx

A1 Journal Article in JOURNAL OF CELL SCIENCE

TNFR1 inhibition with a nanobody protects against EAE development in mice

Sophie SteelandSara Van RyckeghemGriet Van ImschootRiet De RyckeWendy ToussaintLeen VanhoutteChristian VanhoveFilip De VosRoosmarijn VandenbrouckeClaude Libert

A1 Journal Article in SCIENTIFIC REPORTS

2016

Development and validation of a small single-domain antibody that effectively inhibits matrix metalloproteinase 8

Delphine DemeestereEline DejonckheereSophie SteelandPaco HulpiauJurgen HaustraeteNick DevoogdtRielana WichertChristoph Becker-PaulyElien Van WonterghemSylviane Dewaele et al.

A1 Journal Article in MOLECULAR THERAPY

2015

A novel RIPK4-IRF6 connection is required to prevent epithelial fusions characteristic for popliteal pterygium syndromes

Philippe De GrooteHong Tran ThiMathias FransenGiel TangheCorinne UrwylerBram De CraeneKirsten LeursBarbara GilbertGriet Van ImschootRiet De Rycke et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Decreased TNF levels and improved retinal ganglion cell survival in MMP-2 Null mice suggest a role for MMP-2 as TNF sheddase

Lies De GroefManuel Salinas-NavarroGriet Van ImschootClaude LibertRoosmarijn VandenbrouckeLieve Moons

A1 Journal Article in MEDIATORS OF INFLAMMATION

TALEN-mediated apc mutation in Xenopus tropicalis phenocopies familial adenomatous polyposis

Tom Van NieuwenhuysenThomas NaertHong Tran ThiGriet Van ImschootSarah GeursEllen SandersDavid CreytensFrans Van RoyKris Vleminckx

A2 Journal Article in ONCOSCIENCE

2010

Aberrant activation of fatty acid synthesis suppresses primary cilium formation and distorts tissue development

Nicolas WillemarckEvelien RysmanKoen BrusselmansGriet Van ImschootFrank VanderhoydoncKatrien MoerlooseEvelyne LerutGuido VerhoevenFrans Van RoyKris Vleminckx et al.

A1 Journal Article in CANCER RESEARCH

Wnt/β-catenin signaling is involved in the induction and maintenance of primitive hematopoiesis in the vertebrate embryo

Hong Tran ThiBelaid SekkaliGriet Van ImschootSylvie JanssensKris Vleminckx

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2004

P120 catenin is required for morphogenetic movements involved in the formation of the eyes and the cranlofacial skeleton in Xenopus

Malgorzata CiesiolkaMieke DelvaeyeGriet Van ImschootVeerle VerschuereP MCCREAFrans Van RoyKris Vleminckx

A1 Journal Article in JOURNAL OF CELL SCIENCE

2003

The p120 catenin regulates morphogenetic movements in early xenopus embryos by modifying the activity of the rho-family small Gtpases.

M CIESIOLKAM DELVAEYEGriet Van ImschootFrans Van RoyKris Vleminckx