Research Explorer

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Researcher

Gilles Brackman

Awards & Distinctions

52 Results

2019

Phenolic plant extract enrichment of enzymatically mineralized hydrogels

Timothy DouglasMarco Lopez-HerediaAleksandra PulczynskaAgata ŁapaKrzysztof PietrygaDavid SchaubroeckSonia SantosAdriana PaisGilles BrackmanKarel De Schamphelaere et al.

A2 Journal Article in ENGINEERING OF BIOMATERIALS = INŻYNIERIA BIOMATERIAŁÓW

2018

Elucidation of the mechanism behind the potentiating activity of baicalin against Burkholderia cenocepacia biofilms

Lisa SlachmuyldersHeleen Van AckerGilles BrackmanAndrea SassFilip Van NieuwerburghTom Coenye

A1 Journal Article in PLOS ONE

Novel injectable gellan gum hydrogel composites incorporating Zn- and Sr-enriched bioactive glass microparticles : high-resolution X-ray microcomputed tomography, antibacterial and in vitro testing

Timothy DouglasMichal DziadekSvetlana GorodzhaJana LiskovaGilles BrackmanValérie VanhoorneChris VervaetLieve BalcaenMaria del Rosario Florez GarciaAldo R Boccaccini et al.

A1 Journal Article in JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE

Whey protein complexes with green tea polyphenols : antimicrobial, osteoblast-stimulatory, and antioxidant activities

Matthew CarsonJulia K KepplerGilles BrackmanDaniel DawoodMarta VandrovcovaKarim Fawzy El-SayedTom CoenyeKarin SchwarzSusan A ClarkeAndre Skirtach et al.

A1 Journal Article in CELLS TISSUES ORGANS

2017

Ca:Mg:Zn:CO3 and Ca:Mg:CO3 - tri- and bi-elemental carbonate microparticles for novel injectable self-gelling hydrogel-microparticle composites for tissue regeneration

Timothy DouglasKatarzyna SobczykAgata ŁapaKatarzyna WlodarczykGilles BrackmanIrina VidiashevaKatarzyna ReczyńskaKrzysztof PietrygaDavid SchaubroeckVitaliy Bliznuk et al.

A1 Journal Article in BIOMEDICAL MATERIALS

Composites of gellan gum hydrogel enzymatically mineralized with calcium–zinc phosphate for bone regeneration with antibacterial activity

Timothy DouglasMagdalena PilarzMarco Lopez-HerediaGilles BrackmanDavid SchaubroeckLieve BalcaenVitaliy BliznukPeter DubruelChristine Knabe-DucheyneFrank Vanhaecke et al.

A1 Journal Article in JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE

Evaluation of combination therapy for Burkholderia cenocepacia lung infection in different in vitro and in vivo models

Freija Van den DriesscheBieke VanhoutteGilles BrackmanAurélie CrabbéPetra RigoleJurgen VercruysseGlenn VerstraeteDavie CappoenChris VervaetPaul Cos et al.

A1 Journal Article in PLOS ONE

Novel hamamelitannin analogues for the treatment of biofilm related MRSA infections : a scaffold hopping approach

Arno VermoteGilles BrackmanMartijn RisseeuwTom CoenyeSerge Van Calenbergh

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel potentiators for vancomycin in the treatment of biofilm-related MRSA infections via a mix and match approach

Arno VermoteGilles BrackmanMartijn RisseeuwDavie CappoenPaul CosTom CoenyeSerge Van Calenbergh

A1 Journal Article in ACS MEDICINAL CHEMISTRY LETTERS

Pitfalls associated with evaluating enzymatic quorum quenching activity : the case of MomL and its effect on Pseudomonas aeruginosa and Acinetobacter baumannii biofilms

Yunhui ZhangGilles BrackmanTom Coenye

A1 Journal Article in PEERJ

Screening a repurposing library for potentiators of antibiotics against Staphylococcus aureus biofilms

Freija Van den DriesscheGilles BrackmanRosalie SwimberghePetra RigoleTom Coenye

A1 Journal Article in INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Titanium surface functionalization with coatings of chitosan and polyphenol-rich plant extracts

Timothy DouglasSuman KumariKinga DziadekMichal DziadekAnatoly AbalymovPieter CoolsGilles BrackmanTom CoenyeRino MorentMK. Mohan et al.

A1 Journal Article in MATERIALS LETTERS

2016

Design, synthesis and biological evaluation of novel hamamelitannin analogues as potentiators for vancomycin in the treatment of biofilm related Staphylococcus aureus infections

Arno VermoteGilles BrackmanMartijn RisseeuwTom CoenyeSerge Van Calenbergh

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY

Discovery of new diketopiperazines inhibiting Burkholderia cenocepacia quorum sensing in vitro and in vivo

Viola C ScoffoneLaurent R ChiarelliVadim MakarovGilles BrackmanAygun IsrayilovaAlberto AzzalinFederico FornerisOlga RiabovaSventlana SavinaTom Coenye et al.

A1 Journal Article in SCIENTIFIC REPORTS

Don’t let the 'bad bugs' bite: hamamelitannin analogues as adjuvants for vancomycin in the treatment of MRSA biofilm infections

Arno VermoteGilles BrackmanMartijn RisseeuwKoen BreyneEvelyne MeyerP CosTom CoenyeSerge Van Calenbergh

Dressings loaded with cyclodextrin-hamamelitannin complexes increase Staphylococcus aureus susceptibility toward antibiotics both in single as well as in mixed biofilm communities

Gilles BrackmanMaria José Garcia-FernandezJoke LenoirLaurens De MeyerJean Paul RemonThomas De BeerAngel ConcheiroCarmen Alvarez-LorenzoTom Coenye

A1 Journal Article in MACROMOLECULAR BIOSCIENCE

Enrichment of enzymatically mineralized gellan gum hydrogels with phlorotannin-rich Ecklonia cava extract Seanol® to endow antibacterial properties and promote mineralization

Timothy DouglasAgnieszka DokupilKatarzyna ReczyńskaGilles BrackmanMalgorzata Krok-BorkowiczJulia K KepplerMojca BožičPascal Van Der VoortKrzysztof PietrygaSangram Keshari Samal et al.

A1 Journal Article in BIOMEDICAL MATERIALS

Hamamelitannin analogues potentiate antibiotics in the fight against biofilm-related Staphylococcus aureus infections

Arno VermoteGilles BrackmanMartijn RisseeuwKristof Van HeckePaul CosEvelyne MeyerTom CoenyeSerge Van Calenbergh

Hamamelitannin analogues that modulate quorum sensing as potentiators of antibiotics against Staphylococcus aureus

Arno VermoteGilles BrackmanMartijn RisseeuwBieke VanhouttePaul CosKristof Van HeckeKoen BreyneEvelyne MeyerTom CoenyeSerge Van Calenbergh

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In vitro and in vivo biofilm wound models and their application

Gilles BrackmanTom Coenye

A1 Journal Article in ADVANCES IN MICROBIOLOGY, INFECTIOUS DISEASES AND PUBLIC HEALTH, VOL 1

Injectable self-gelling composites for bone tissue engineering based on gellan gum hydrogel enriched with different bioactive glasses

Timothy DouglasWojciech PiwowarczyckJana LiskovaDavid SchaubroeckSander C LeeuwenburghGilles BrackmanLieve BalcaenRainer DetschHeidi DeclercqKatarzyna Cholewa-Kowalska et al.

The quorum sensing inhibitor hamamelitannin increases antibiotic susceptibility of Staphylococcus aureus biofilms by affecting peptidoglycan biosynthesis and eDNA release

Gilles BrackmanKoen BreyneRiet De RyckeArno VermoteFilip Van NieuwerburghEvelyne MeyerSerge Van CalenberghTom Coenye

A1 Journal Article in SCIENTIFIC REPORTS

2015

D-Enantiomeric peptides that eradicate wild-type and multidrug-resistant biofilms and protect against lethal Pseudomonas aeruginosa infections

César de la Fuente-NúñezFany ReffuveilleSarah C MansourShauna L Reckseidler-ZentenoDiego HernándezGilles BrackmanTom CoenyeRobert EW Hancock

A1 Journal Article in CHEMISTRY & BIOLOGY

Development and in vitro testing of gelatin-based antibacterial burn wound dressings

Birgit StubbeSandra Van VlierbergheGilles BrackmanMohaddeseh Amiri ArefHenk HoeksemaStan MonstreyFrank VanhaeckePiet Van EspenKarolien De WaelTom Coenye et al.

Inactivation of biofilms using a low power atmospheric pressure argon plasma jet; the role of entrained nitrogen

Leila TaghizadehGilles BrackmanAnton NikiforovJoost van der MullenChristophe LeysTom Coenye

A1 Journal Article in PLASMA PROCESSES AND POLYMERS

Inhibition of quorum sensing in Staphylococcus spp.

Gilles BrackmanTom Coenye

A1 Journal Article in CURRENT PHARMACEUTICAL DESIGN

MomL, a novel marine-derived N-acyl homoserine lactonase from Muricauda olearia

Kaihao TangYing SuGilles BrackmanFangyuan CuiYunhui ZhangXiaochong ShiTom CoenyeXiao-Hua Zhang

A1 Journal Article in APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Phenotypic characterization of an international Pseudomonas aeruginosa reference panel: strains of cystic fibrosis (CF) origin show less in vivo virulence than non-CF strains

Louise CullenRebecca WeiserTomasz OlszakRita F MaldonadoAna S MoreiraLisa SlachmuyldersGilles BrackmanTsvetelina S Paunova-KrastevaPaulina ZarnowiecGrzegorz Czerwonka et al.

A1 Journal Article in MICROBIOLOGY-SGM

Quorum sensing inhibitors as anti-biofilm agents

Gilles BrackmanTom Coenye

A1 Journal Article in CURRENT PHARMACEUTICAL DESIGN

2014

Injectable self-gelling composites for bone tissue engineering based on gellan gum hydrogel enriched with different bioglasses

Timothy DouglasWojciech PiwowarczykElzbieta PamulaJana LiskovaDavid SchaubroeckSander CG LeeuwenburghGilles BrackmanLieve BalcaenRainer DetschHeidi Declercq et al.

A1 Journal Article in BIOMEDICAL MATERIALS

Materials with fungi-bioinspired surface for efficient binding and fungi-sensitive release of antifungal agents.

Tania SeguraAna M PugaGuillermina BurilloJosé LlovoGilles BrackmanTom CoenyeAngel ConcheiroCarmen Alvarez-Lorenzo

A1 Journal Article in BIOMACROMOLECULES

Optimization of resazurin-based viability staining for quantification of microbial biofilms

Freija Van den DriesschePetra RigoleGilles BrackmanTom Coenye

A1 Journal Article in JOURNAL OF MICROBIOLOGICAL METHODS

Thiazolidinedione derivatives as novel agents against Propionibacterium acnes biofilms

Gilles BrackmanKatrien ForierAAA Al QuntarEvelien De CanckClaes E EnkMorris SrebnikKevin BraeckmansTom Coenye

A1 Journal Article in JOURNAL OF APPLIED MICROBIOLOGY

Wound debridement and antibiofilm properties of gamma-ray DMAEMA-grafted onto cotton gauzes

Marco A Luna-StraffonAngel Contreras-GarcíaGilles BrackmanTom CoenyeAngel ConcheiroCarmen Alvarez-LorenzoEmilio Bucio

A1 Journal Article in CELLULOSE

2013

Antiseptic cyclodextrin-functionalized hydrogels and gauzes for loading and delivery of benzalkonium chloride

Maria José Garcia-FernandezGilles BrackmanTom CoenyeAngel ConcheiroCarmen Alvarez-Lorenzo

A1 Journal Article in BIOFOULING

Biofilm inhibitory and eradicating activity of wound care products against Staphylococcus aureus and Staphylococcus epidermidis biofilms in an in vitro chronic wound model

Gilles BrackmanLaurens De MeyerHans NelisTom Coenye

A1 Journal Article in JOURNAL OF APPLIED MICROBIOLOGY

Comment on: Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model

Gilles BrackmanTom Coenye

A1 Journal Article in JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Phenotypic and genotypic characterisation of Burkholderia cenocepacia J2315 mutants affected in homoserine lactone and diffusible signal factor-based quorum sensing systems suggests interplay between both types of systems

Claudia UdineGilles BrackmanSilvia BazziniSilvia BuroniHeleen Van AckerMaria Rosalia PascaGiovanna RiccardiTom Coenye

A1 Journal Article in PLOS ONE

Quorum sensing inhibitors: how strong is the evidence?

Tom DefoirdtGilles BrackmanTom Coenye

A1 Journal Article in TRENDS IN MICROBIOLOGY

Synthesis and evaluation of thiazolidinedione and dioxazaborocane analogues as inhibitors of AI-2 quorum sensing in Vibrio harveyi

Gilles BrackmanAbed Al Aziz Al QuntarClaes D EnkIzet KaralicHans NelisSerge Van CalenberghMorris SrebnikTom Coenye

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY

2012

A quorum sensing-disrupting brominated thiophenone with a promising therapeutic potential to treat luminescent vibriosis

Tom DefoirdtTore BennecheGilles BrackmanTom CoenyePatrick SorgeloosAnne Aamdal Scheie

A1 Journal Article in PLOS ONE

Eradication of Propionibacterium acnes biofilms by plant extracts and putative identification of icariin, resveratrol and salidroside as active compounds

Tom CoenyeGilles BrackmanPetra RigoleEvy De WitteKris HonraetBart RosselHans Nelis

A1 Journal Article in PHYTOMEDICINE

Inhibition of quorum sensing as a novel antimicrobial strategy

Gilles BrackmanHans NelisTom Coenye

Bookchapter in Antimicrobial drug discovery : emerging strategies

Synthesis and evaluation of the quorum sensing inhibitory effect of substituted triazolyldihydrofuranones

Gilles BrackmanMartijn RisseeuwShari CelenPaul CosLouis MaesHans NelisSerge Van CalenberghTom Coenye

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY

2011

Biofilm inhibition and drug-eluting properties of novel DMAEMA-modified polyethylene and silicone rubber surfaces

Angel Contreras-GarciaEmilio BucioGilles BrackmanTom CoenyeAngel ConcheiroCarmen Alvarez-Lorenzo

A1 Journal Article in BIOFOULING

Interfering with quorum sensing as a novel strategy to combat bacterial infections

Gilles BrackmanTom CoenyeHans Nelis

Isolation and identification of quorum quenching bacteria from environmental samples

Steven ChristiaenGilles BrackmanHans NelisTom Coenye

A1 Journal Article in JOURNAL OF MICROBIOLOGICAL METHODS

Quorum sensing inhibitors increase the susceptibility of bacterial biofilms to antibiotics in vitro and in vivo

Gilles BrackmanPaul CosLouis MaesHans NelisTom Coenye

A1 Journal Article in ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structure-activity relationship of cinnamaldehyde analogs as inhibitors of AI-2 based quorum sensing and their effect on virulence of vibrio spp

Gilles BrackmanShari CelenUlrik HillaertSerge Van CalenberghPaul CosLouis MaesHans NelisTom Coenye

A1 Journal Article in PLOS ONE

2009

AI-2 quorum sensing inhibitors affect the starvation response and reduce virulence in several Vibrio species, most likely by interfering with LuxPQ

Gilles BrackmanShari CelenSri Kartik BaruahPeter BossierSerge Van CalenberghHans NelisTom Coenye

A1 Journal Article in MICROBIOLOGY-SGM

Use of quorum sensing inhibitors to interfere with biofilm formation and development in Burkholderia multivorans and Burkholderia cenocepacia

Gilles BrackmanUlrik HillaertSerge Van CalenberghHans NelisTom Coenye

A1 Journal Article in RESEARCH IN MICROBIOLOGY

2008

Cinnamaldehyde and cinnamaldehyde derivatives reduce virulence in Vibrio spp. by decreasing the DNA-binding activity of the quorum sensing response regulator LuxR

Gilles BrackmanTom DefoirdtCarol MiyamotoPeter BossierSerge Van CalenberghHans NelisTom Coenye

A1 Journal Article in BMC MICROBIOLOGY