Research Explorer

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Researcher

Georges Leclercq

Publications & Research Data

Awards & Distinctions

192 Results

2024

Knocking out CD70 rescues CD70-specific nanoCAR T cells from antigen-induced exhaustion

Stijn De MunterJuliane L. BuhlLaurenz De CockAlexander Van ParysWillem DaneelsEva PascalLucas DeseinsJoline IngelsGlenn GoetgelukHanne Jansen et al.

A1 Journal Article in CANCER IMMUNOLOGY RESEARCH

Neoantigen-targeted dendritic cell vaccination in lung cancer patients induces long-lived T cells exhibiting the full differentiation spectrum

Joline IngelsLaurenz De CockDieter StevensRupert MayerFabien Henri TheryGuillem Sanchez SanchezDavid VermijlenKarin WeeningSaskia De SmetNele Lootens et al.

A1 Journal Article in CELL REPORTS MEDICINE

TL1A and IL-18 synergy promotes GM-CSF-dependent thymic granulopoiesis in mice

Mario Ruiz PérezChristian MaueröderWolf SteelsBruno VerstraetenSahine LameireWei XieLaura WyckaertJelle HuysentruytTatyana DivertRia Roelandt et al.

A1 Journal Article in CELLULAR & MOLECULAR IMMUNOLOGY

Type 1 immunity enables neonatal thymic ILC1 production

Peter TougaardMario Ruiz PérezWolf SteelsJelle HuysentruytBruno VerstraetenJessica VettersTatyana DivertAmanda GonçalvesRia RoelandtNozomi Takahashi et al.

A1 Journal Article in SCIENCE ADVANCES

2023

Intrathymic dendritic cell-biased precursors promote human T cell lineage specification through IRF8-driven transmembrane TNF

Kai Ling LiangJuliette RoelsMarieke LavaertTom PuttemanLena BoehmeLaurentijn TillemanImke VelgheValentina PegorettiInge Van de WalleStephanie Sontag et al.

A1 Journal Article in NATURE IMMUNOLOGY

IRF2 and TXNIP : two regulators of human NK cell development and function

Eva PersynGeorges Leclercq

Single-cell profiling identifies a novel human polyclonal unconventional T cell lineage

Lore BillietLaurenz De CockGuillem Sanchez SanchezRupert MayerGlenn GoetgelukStijn De MunterMelissa PilleJoline IngelsHanne JansenKarin Weening et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

The Wiskott–Aldrich syndrome protein is required for positive selection during T-cell lineage differentiation

Melissa PilleJohn AvilaGuillem Sanchez SanchezGlenn GoetgelukStijn De MunterHanne JansenLore BillietKarin WeeningHaipeng XueSarah Bonte et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

2022

ETS1 and RUNX2 : two important transcriptional regulators of human NK cell development, phenotype and function

Sigrid WahlenGeorges Leclercq

IRF2 is required for development and functional maturation of human NK cells

Eva PersynSigrid WahlenLaura KiekensWouter Van LoockeHannah SiweEls Van AmmelZenzi De VosFilip Van NieuwerburghPatrick MatthysTom Taghon et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Severe COVID-19 patients display hyper-activated NK cells and NK cell-platelet aggregates

Bert Malengier-DevliesJessica FiltjensKourosh AhmadzadehBram BoeckxJessica VandenhauteAmber De VisscherEline BernaertsTania MiteraCato JacobsLore Vanderbeke et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Small-scale manufacturing of neoantigen-encoding messenger RNA for early-phase clinical trials

Joline IngelsLaurenz De CockRupert MayerPam DevrekerKarin WeeningKelly HeynsNele LootensSaskia De SmetMarieke BrusseelStijn De Munter et al.

A1 Journal Article in CYTOTHERAPY

T-BET and EOMES : the powerful pair in human NK cell differentiation and ILC3 plasticity

Laura KiekensGeorges Leclercq

T-BET drives the conversion of human type 3 innate lymphoid cells into functional NK cells

Laura KiekensSigrid WahlenEva PersynZenzi De VosTom TaghonBart VandekerckhoveGeorges Leclercq

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

The transcription factor RUNX2 drives the generation of human NK cells and promotes tissue residency

Sigrid WahlenFilip MatthijssensWouter Van LoockeSylvie TaveirneLaura KiekensEva PersynEls Van AmmelZenzi De VosStijn De MunterPatrick Matthys et al.

A1 Journal Article in ELIFE

Transcriptional dynamics and epigenetic regulation of E and ID protein encoding genes during human T cell development

Juliette RoelsJolien Van HulleMarieke LavaertAnna KuchmiySteven StrubbeTom PuttemanBart VandekerckhoveGeorges LeclercqFilip Van NieuwerburghLena Boehme et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

TXNIP promotes human NK cell development but is dispensable for NK cell functionality

Eva PersynSigrid WahlenLaura KiekensSylvie TaveirneWouter Van LoockeEls Van AmmelFilip Van NieuwerburghTom TaghonBart VandekerckhovePieter Van Vlierberghe et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2021

A novel non-coding variant in DCLRE1C results in deregulated splicing and induces SCID through the generation of a truncated ARTEMIS protein that fails to support V(D)J recombination and DNA damage repair

Steven StrubbeMarieke De BruyneUlrich PannickeElien BeylsBart VandekerckhoveGeorges LeclercqElfride De BaereVictoria BordonAnne VralKlaus Schwarz et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

HES1 and HES4 have non-redundant roles downstream of Notch during early human T-cell development

Matthias De DeckerMarieke LavaertJuliette RoelsLaurentijn TillemanBart VandekerckhoveGeorges LeclercqFilip Van NieuwerburghPieter Van VlierbergheTom Taghon

A1 Journal Article in HAEMATOLOGICA

In vitro OP9-DL1 co-culture and subsequent maturation in the presence of IL-21 generates tumor antigen-specific T cells with a favorable less-differentiated phenotype and enhanced functionality

Sarah BonteStijn De MunterLore BillietGlenn GoetgelukJoline IngelsHanne JansenMelissa PilleLaurenz De CockKarin WeeningTom Taghon et al.

A1 Journal Article in ONCOIMMUNOLOGY

T-BET and EOMES accelerate and enhance functional differentiation of human natural killer cells

Laura KiekensWouter Van LoockeSylvie TaveirneSigrid WahlenEva PersynEls Van AmmelZenzi De VosPatrick MatthysFilip Van NieuwerburghTom Taghon et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Treatment of a patient with severe cytomegalovirus (CMV) infection after haploidentical stem cell transplantation with donor-derived CMV-specific T cells

Joline IngelsSaskia De SmetKelly HeynsNele LootensJonas SegaertTom TaghonGeorges LeclercqKarim VermaelenEvelyne WillemsEtienne Baudoux et al.

A1 Journal Article in ACTA CLINICA BELGICA

2020

Conventional and computational flow cytometry analyses reveal sustained human intrathymic T cell development from birth until puberty

Marieke LavaertBrecht ValckeBart VandekerckhoveGeorges LeclercqKai Ling LiangTom Taghon

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Distinct and temporary-restricted epigenetic mechanisms regulate human αβ and γδ T cell development

Juliette RoelsAnna KuchmiyMatthias De DeckerSteven StrubbeMarieke LavaertKai Ling LiangGeorges LeclercqBart VandekerckhoveFilip Van NieuwerburghPieter Van Vlierberghe et al.

A1 Journal Article in NATURE IMMUNOLOGY

Distinct Notch1 and BCL11B requirements mediate human γδ/αβ T cell development

Anne-Catherine DolensKaat DurinckMarieke LavaertJoni Van der MeulenImke VelgheJelle De MedtsKarin WeeningJuliette RoelsKatrien De MulderPieter-Jan Volders et al.

A1 Journal Article in EMBO REPORTS

Human thymic CD10+ PD-1+ intraepithelial lymphocyte precursors acquire interleukin-15 responsiveness at the CD1a– CD95+ CD28– CCR7– developmental stage

Lore BillietGlenn GoetgelukSarah BonteStijn De MunterLaurenz De CockMelissa PilleJoline IngelsHanne JansenKarin WeeningFilip Van Nieuwerburgh et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Integrated scRNA-seq identifies human postnatal thymus seeding progenitors and regulatory dynamics of differentiating immature thymocytes

Marieke LavaertKai Ling LiangNiels VandammeJong-Eun ParkJuliette RoelsMonica S. KowalczykBo LiOrr AshenbergMarcin TabakaDanielle Dionne et al.

A1 Journal Article in IMMUNITY

Rapid and effective generation of nanobody based CARs using PCR and Gibson Assembly

Stijn De MunterAlexander Van ParysLayla BralJoline IngelsGlenn GoetgelukSarah BonteMelissa PilleLore BillietKarin WeeningAnnick Verhee et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

T-cells with a single tumor antigen-specific T-cell receptor can be generated in vitro from clinically relevant stem cell sources

Sarah BonteStijn De MunterGlenn GoetgelukJoline IngelsMelissa PilleLore BillietTom TaghonGeorges LeclercqBart VandekerckhoveTessa Kerre

A1 Journal Article in ONCOIMMUNOLOGY

The transcription factor ETS1 is an important regulator of human NK cell development and terminal differentiation

Sylvie TaveirneSigrid WahlenWouter Van LoockeLaura KiekensEva PersynEls Van AmmelKatrien De MulderJuliette RoelsLaurentijn TillemanMarc Aumercier et al.

A1 Journal Article in BLOOD

2018

Comparative analysis of the immune responses induced by native versus recombinant versions of the ASP-based vaccine against the bovine intestinal parasite Cooperia oncophora

Ana González HernándezJimmy BorlooIris PeelaersStijn CasaertGeorges LeclercqEdwin ClaereboutPeter Geldhof

A1 Journal Article in INTERNATIONAL JOURNAL FOR PARASITOLOGY

Innate lymphoid cells in the upper airways : importance of CD117 and IL-1RI expression

Koen Van CrombruggenSylvie TaveirneGabriële HoltappelsGeorges LeclercqClaus Bachert

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

2017

A murine intestinal intraepithelial NKp46-negative innate lymphoid cell population characterized by group 1 properties

Aline Van AckerKonrad GronkeAindrila BiswasLiesbet MartensYvan SaeysJessica FiltjensSylvie TaveirneEls Van AmmelTessa KerrePatrick Matthys et al.

A1 Journal Article in CELL REPORTS

Antigen receptor-redirected T cells derived from hematopoietic precursor cells lack expression of the endogenous TCR/CD3 receptor and exhibit specific antitumor capacities

Yasmine Van CaeneghemStijn De MunterPaola TieppoGlenn GoetgelukKarin WeeningGreet VerstichelSarah BonteTom TaghonGeorges LeclercqTessa Kerre et al.

A1 Journal Article in ONCOIMMUNOLOGY

Differential effects of CORM-2 and CORM-401 in murine intestinal epithelial MODE-K cells under oxidative stress

Dinesh BabuGeorges LeclercqRoberto MotterliniRomain Lefebvre

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

Inflammatory gene expression profile and defective interferon-γ and granzyme K in natural killer cells from systemic juvenile idiopathic arthritis patients

Karen PutJessica VandenhauteAnneleen AvauAnnemarie van NieuwenhuijzeEllen BrisseTim DierckxOmer RutgeertsJosselyn E Garcia-PerezJaan ToelenMark Waer et al.

A1 Journal Article in ARTHRITIS & RHEUMATOLOGY

Porcine NK cells display features associated with antigen-presenting cells

Steffi De PelsmaekerBert DevriendtGeorges LeclercqHerman Favoreel

A1 Journal Article in JOURNAL OF LEUKOCYTE BIOLOGY

The checkpoint for agonist selection precedes conventional selection in human thymus

Greet VerstichelDavid VermijlenLiesbet MartensGlenn GoetgelukMargreet BrouwerNicolas ThiaultYasmine Van CaeneghemStijn De MunterKarin WeeningSarah Bonte et al.

A1 Journal Article in SCIENCE IMMUNOLOGY

2016

Activation by SLAM family receptors contributes to NK cell mediated 'missing-self' recognition

Elisenda Alari-PahissaCamille GrandclémentBeena Jeevan-RajGeorges LeclercqAndré VeilletteWerner Held

A1 Journal Article in PLOS ONE

Difference in replication of low-passage MCMV HaNa1 in BALB/c, C57BL/6 and NOD mice and role of different branches of immunity in susceptibility

Jun XiangShunchuan ZhangGeorges LeclercqHans Nauwynck

A1 Journal Article in VIRUS RESEARCH

Expression of the inhibitory Ly49E receptor is not critically involved in the immune response against cutaneous, pulmonary or liver tumours

Jessica FiltjensJiri KeirsseEls Van AmmelSylvie TaveirneAline Van AckerTessa KerreTom TaghonBart VandekerckhoveJean PlumJo A Van Ginderachter et al.

A1 Journal Article in SCIENTIFIC REPORTS

GATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fate

Inge Van de WalleAnne-Catherine DolensKaat DurinckKatrien De MulderWouter Van LoockeSagar DamleEls WaegemansJelle De MedtsImke VelgheMagda De Smedt et al.

A1 Journal Article in NATURE COMMUNICATIONS

Host protective ASP-based vaccine against the parasitic nematode Ostertagia ostertagi triggers NK cell activation and mixed IgG1-IgG2 response

Ana González HernándezStefanie Van CoppernolleJimmy BorlooFrederik Van MeulderOonagh PaerewijckIris PeelaersGeorges LeclercqEdwin ClaereboutPeter Geldhof

A1 Journal Article in SCIENTIFIC REPORTS

NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNF AIP3/A20

Michael DrennanSrinath GovindarajanEveline VerheugenJonathan CoquetJens StaalConor Mc GuireTom TaghonGeorges LeclercqRudi BeyaertGeert van Loo et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

The Ly49E receptor inhibits the immune control of acute Trypanosoma cruzi infection

Jessica FiltjensNicolas ColtelSabrina CencigSylvie TaveirneEls Van AmmelAline Van AckerTessa KerrePatrick MatthysTom TaghonBart Vandekerckhove et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

The role of Ly49E expression on intraepithelial T and ILC lymphocytes in mediating intestinal immune response

Aline Van AckerGeorges LeclercqJean Plum

The role of Ly49E receptor expression on murine intraepithelial lymphocytes in intestinal cancer development and progression

Aline Van AckerEls LouagieJessica FiltjensSylvie TaveirneEls Van AmmelTessa KerreDirk ElewautTom TaghonBart VandekerckhoveJean Plum et al.

A1 Journal Article in CANCER IMMUNOLOGY IMMUNOTHERAPY

2015

A candidate agonist selected CD8SP subpopulation in the human thymus and cord blood

Greet VerstichelAline Van AckerGeorges LeclercqBart Vandekerckhove

Antioxidant potential of CORM-A1 and resveratrol during TNF-α/cycloheximide-induced oxidative stress and apoptosis in murine intestinal epithelial MODE-K cells

Dinesh BabuGeorges LeclercqVera GoossensQuinten RemijsenPeter VandenabeeleRoberto MotterliniRomain Lefebvre

A1 Journal Article in TOXICOLOGY AND APPLIED PHARMACOLOGY

Chimeric antigen receptor transgenic, T cell receptor/CD3 negative monospecific T cells generated from cord blood CD34 positive cells

Yasmine Van CaeneghemGlenn GoetgelukKarin WeeningGreet VerstichelSarah BonteTom TaghonGeorges LeclercqFritz OffnerHinrich AbkenTessa Kerre et al.

In vitro human embryonic stem cell hematopoiesis mimics MYB-independent yolk sac hematopoiesis

Stijn VanheeKatrien De MulderYasmine Van CaeneghemGreet VerstichelNadine Van RoyBjörn MentenImke VelgheJan PhilippéDominique De BleserBart Lambrecht et al.

A1 Journal Article in HAEMATOLOGICA

Mitochondria and NADPH oxidases are the major sources of TNF-α/cycloheximide-induced oxidative stress in murine intestinal epithelial MODE-K cells

Dinesh BabuGeorges LeclercqVera GoossensTom Vanden BergheEvelien Van HammePeter VandenabeeleRomain Lefebvre

A1 Journal Article in CELLULAR SIGNALLING

The role of the natural killer receptor Ly49E in the immune response of liver NK cells and skin γδ T cells

Jessica FiltjensGeorges LeclercqJean Plum

2014

Contribution of the Ly49E natural killer receptor in the immune response to Plasmodium berghei infection and control of hepatic parasite development

Jessica FiltjensLander FoquetSylvie TaveirneEls Van AmmelMandy VanheesAline Van AckerTessa KerreTom TaghonBart VandekerckhoveJean Plum et al.

A1 Journal Article in PLOS ONE

In vitro generation of mature, naive antigen-specific CD8⁺ T cells with a single T-cell receptor by agonist selection

SYLVIA SNAUWAERTGreet VerstichelSarah BonteGlenn GoetgelukStijn VanheeYasmine Van CaeneghemKatrien De MulderCarlo HeirmanHans StaussMiriam HM Heemskerk et al.

A1 Journal Article in LEUKEMIA

In vitro human embryonic stem cell hematopoiesis mimics MYB independent yolk sac hematopoiesis

Stijn VanheeKatrien De MulderYasmine Van CaeneghemNadine Van RoyBjörn MentenImke VelgheJan PhilippéTom TaghonGeorges LeclercqTessa Kerre et al.

Ly49E Expression on CD8αα-expressing intestinal intraepithelial lymphocytes plays no detectable role in the development and progression of experimentally induced inflammatory bowel diseases

Aline Van AckerJessica FiltjensSophie Van WeldenSylvie TaveirneEls Van AmmelMandy VanheesLindsey DevisscherTessa KerreTom TaghonBart Vandekerckhove et al.

A1 Journal Article in PLOS ONE

Notch3 activation is sufficient but not required for inducing human T-lineage specification

Els WaegemansInge Van de WalleJelle De MedtsMagda De SmedtTessa KerreBart VandekerckhoveGeorges LeclercqTao WangJean PlumTom Taghon

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Sources of ROS during TNF-alpha-induced oxidative stress in murine intestinal epithelial mode-K cells

Dinesh BabuGeorges LeclercqRomain Lefebvre

Spray-dried polyelectrolyte microparticles in oral antigen delivery : stability, biocompatibility and cellular uptake

Rebecca De SmetStephanie VERSCHUERELiesbeth AllaisGeorges LeclercqMarijke DierendonckBruno De GeestIsabel Van DriesscheTine DemoorClaude Cuvelier

A1 Journal Article in BIOMACROMOLECULES

Systemic juvenile idiopathic arthritis–like syndrome in mice following stimulation of the immune system with Freund's complete adjuvant: regulation by interferon-γ

Anneleen AvauTania MiteraStéphanie PutKaren PutEllen BrisseJessica FiltjensCatherine UyttenhoveJacques Van SnickAdrian ListonGeorges Leclercq et al.

A1 Journal Article in ARTHRITIS AND RHEUMATOLOGY

2013

Abundant stage-dependent Ly49E expression by liver NK cells is not essential for their differentiation and function

Jessica FiltjensSylvie TaveirneAline Van AckerEls Van AmmelMandy VanheesTessa KerreTom TaghonBart VandekerckhoveJean PlumGeorges Leclercq

A1 Journal Article in JOURNAL OF LEUKOCYTE BIOLOGY

CMYB expression during human in vitro hematopoiesis

Stijn VanheeYasmine Van CaeneghemKatrien De MulderImke VelgheSylvie TaveirneNadine Van RoyBjörn MentenSYLVIA SNAUWAERTGreet VerstichelMelissa Dullaers et al.

Differential Ly49e expression pathways in resting versus TCR-activated intraepithelial γδ T cells

Tina Van Den BroeckEls Van AmmelMaarten DelforcheSylvie TaveirneTessa KerreBart VandekerckhoveTom TaghonJean PlumGeorges Leclercq

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Education of murine NK cells requires both cis and trans recognition of MHC class I molecules

Stéphanie BessolesGeorgi S AngelovJonathan BackGeorges LeclercqEric VivierWerner Held

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Mitochondrial ROS is involved during TNF-A-INDUCED oxidative stress in intestinal epthelial cells

Dinesh BabuGeorges LeclercqQuinten RemijsenRoberto MotterliniRomain Lefebvre

Specific Notch receptor-ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength

Inge Van de WalleEls WaegemansJelle De MedtsGreet De SmetMagda De SmedtSYLVIA SNAUWAERTBart VandekerckhoveTessa KerreGeorges LeclercqJean Plum et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

The influence of CD27/CD70 interaction on the development, survival and function of murine natural killer cells

Veerle De ColvenaerGeorges Leclercq

β-Glucan microparticles are good candidates for mucosal antigen delivery in oral vaccination

Rebecca De SmetTine DemoorStephanie VerschuereMelissa DullaersGary R OstroffGeorges LeclercqLiesbeth AllaisCharles PiletteMarijke DierendonckBruno De Geest et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

2012

IL-15 augments TCR-induced CD4⁺ T cell expansion in vitro by inhibiting the suppressive function of CD25High CD4⁺ T cells

Tom Van BelleHans DoomsTom BoonefaesXiao-Qing WeiGeorges LeclercqJohan Grooten

A1 Journal Article in PLOS ONE

Influence of CORM-A1 and resveratrol on TNF-a-induced oxidative stress and apoptosis in murine MODE-K intestinal epithelial cells

Dinesh BabuOle De BackerStefaan SoenenKoen RaemdonckGeorges LeclercqR MotterliniRomain Lefebvre

Influence of CORM-A1 on TNF-alpha-induced oxidative stress and apoptosis in mode-K cells

Dinesh BabuOle De BackerStefaan SoenenKoen RaemdonckGeorges LeclercqRoberto MotterliniRomain Lefebvre

Matrix metalloprotease 8-dependent extracellular matrix cleavage at the blood-CSF barrier contributes to lethality during systemic inflammatory diseases

Roosmarijn VandenbrouckeEline DejonckheerePhilippe Van LintDelphine DemeestereElien Van WonterghemIneke VanlaereLeen PuimègeFilip Van HauwermeirenRiet De RyckeConor Mc Guire et al.

A1 Journal Article in JOURNAL OF NEUROSCIENCE

Notch induces human T-cell receptor γδ+ thymocytes to differentiate along a parallel, highly proliferative and bipotent CD4 CD8 double-positive pathway

Stefanie Van CoppernolleStijn VanheeGreet VerstichelSYLVIA SNAUWAERTA van der SpekImke VelgheMieke SinnesaelMH HeemskerkTom TaghonGeorges Leclercq et al.

A1 Journal Article in LEUKEMIA

Notch ligands control the human alpha beta/gamma delta lineage choice through receptor-specific induction of differential Notch signal strength

Tom TaghonInge Van de WalleEls WaegemansJelle De MedtsGreet De SmetMagda De SmedtBart VandekerckhoveTessa KerreGeorges LeclercqTao Wang et al.

RHAMM/HMMR (CD168) is not an ideal target antigen for immunotherapy of acute myeloid leukemia

SYLVIA SNAUWAERTStijn VanheeGlenn GoetgelukGreet VerstichelYasmine Van CaeneghemImke VelgheJan PhilippéZwi N BernemanJean PlumTom Taghon et al.

A1 Journal Article in HAEMATOLOGICA-THE HEMATOLOGY JOURNAL

TNF-α/cycloheximide-induced oxidative stress and apoptosis in murine intestinal epithelial MODE-K cells

Dinesh BabuStefaan SoenenKoen RaemdonckGeorges LeclercqOle De BackerRoberto MotterliniRomain Lefebvre

A1 Journal Article in CURRENT PHARMACEUTICAL DESIGN

2011

CD27-deficient mice show normal NK-cell differentiation but impaired function upon stimulation

Veerle De ColvenaerSylvie TaveirneMaarten DelforcheMagda De SmedtBart VandekerckhoveTom TaghonLouis BoonJean PlumGeorges Leclercq

A1 Journal Article in IMMUNOLOGY AND CELL BIOLOGY

Double positive and double negative TCR gamma delta plus cells independently generate mature functional TCR gamma delta plus cells in the human thymus

Stefanie Van CoppernolleStijn VanheeGreet VerstichelSYLVIA SNAUWAERTImke VelgheMieke SinnesaelA van der SpekTom TaghonGeorges LeclercqJean Plum et al.

In vitro generation of immune cells from pluripotent stem cells

Bart VandekerckhoveStijn VanheeStefanie Van CoppernolleSYLVIA SNAUWAERTImke VelgheTom TaghonGeorges LeclercqTessa KerreJean Plum

A1 Journal Article in FRONTIERS IN BIOSCIENCE-LANDMARK

Inhibitory receptors specific for MHC class I educate murine NK cells but not CD8αα intestinal intraepithelial T lymphocytes

Sylvie TaveirneJessica FiltjensEls Van AmmelVeerle De ColvenaerTessa KerreTom TaghonBart VandekerckhoveJean PlumWerner HeldGeorges Leclercq

A1 Journal Article in BLOOD

Jagged2 acts as a Delta-like Notch ligand during early hematopoietic cell fate decisions

Inge Van de WalleGreet De SmetMartina GärtnerMagda De SmedtEls WaegemansBart VandekerckhoveGeorges LeclercqJean PlumJon C AsterIrwin D Bernstein et al.

A1 Journal Article in BLOOD

Langerhans cells are not required for epidermal Vγ3 T cell homeostasis and function

Sylvie TaveirneVeerle De ColvenaerTina Van Den BroeckEls Van AmmelClare L BennettTom TaghonBart VandekerckhoveJean PlumBjörn E ClausenDaniel H Kaplan et al.

A1 Journal Article in JOURNAL OF LEUKOCYTE BIOLOGY

Regulation of natural killer cells and non-conventional T cells

Sylvie TaveirneGeorges LeclercqJean Plum

T-lymphoid differentiation potential measured in vitro is higher in CD34+CD38-/lo hematopoietic stem cells from umbilical cord blood than from bone marrow and is an intrinsic property of the cells

Magda De SmedtGeorges LeclercqBart VandekerckhoveTessa KerreTom TaghonJean Plum

A1 Journal Article in HAEMATOLOGICA-THE HEMATOLOGY JOURNAL

2010

Continuous CD27 triggering in vivo strongly reduces NK cell numbers

Veerle De ColvenaerSylvie TaveirneJörg HamannAlex M de BruinMagda De SmedtTom TaghonBart VandekerckhoveJean PlumRené van LierGeorges Leclercq

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

2009

A Role for cis Interaction between the Inhibitory Ly49A Receptor and MHIC Class I for Natural Killer Cell Education

Anick ChalifourLeonardo ScarpellinoJonathan BackPetter BrodinEstelle DevevreFrederic GrosFrederic LevyGeorges LeclercqPetter HoglundFriedrich Beermann et al.

A1 Journal Article in Immunity

Activated CD4⁺CD25⁺ regulatory T cells inhibit osteoclastogenesis and collagen-induced arthritis

K KelchtermansL GeboesT MiteraD HuskensGeorges LeclercqP Matthys

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

An early decrease in Notch activation is required for human TCR-αβ lineage differentiation at the expense of TCR-γδ T cells

Inge Van de WalleGreet De SmetMagda De SmedtBart VandekerckhoveGeorges LeclercqJean PlumTom Taghon

A1 Journal Article in BLOOD

CD4 and CD8 TCR alpha beta cells are selected on MHC expressed on thymocyte precursors in OP9-DL1 cultures

Stefanie Van CoppernolleBart VandekerckhoveGreet VerstichelImke VelgheTom TaghonGeorges LeclercqJean PlumTessa Kerre

Differential expression of CD97 on human lymphocyte subsets and limited effect of CD97 antibodies on allogeneic T-cell stimulation

E.N. KopM. MatmatiW. PouwelsGeorges LeclercqP.P TakJörg Hamann

A1 Journal Article in IMMUNOLOGY LETTERS

Functionally mature CD4 and CD8 TCRαβ cells are generated in OP9-DL1 cultures from human CD34+ hematopoietic cells

Stefanie Van CoppernolleGreet VerstichelFrank TimmermansImke VelgheDavid VermijlenMagda De SmedtGeorges LeclercqJean PlumTom TaghonBart Vandekerckhove et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Generation of T cells from human embryonic stem cell-derived hematopoietic zones

Frank TimmermansImke VelgheLieve VanwalleghemMagda De SmedtStefanie Van CoppernolleTom TaghonHarry MooreGeorges LeclercqAnton LangerakTessa Kerre et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Notch signaling is required for proliferation but not for differentiation at a well-defined β-selection checkpoint during human T-cell development

Tom TaghonInge Van de WalleGreet De SmetMagda De SmedtGeorges LeclercqBart VandekerckhoveJean Plum

A1 Journal Article in BLOOD

Type I interferon drives tumor necrosis factor-induced lethal shock

Liesbeth HuysFilip Van HauwermeirenLien DejagerEline DejonckheereStefan LienenklausSiegfried WeissGeorges LeclercqClaude Libert

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Unique features of Ly49E expression and function in natural killer cells and intraepithelial γδ T cells

Tina Van Den BroeckGeorges LeclercqJean Plum

2008

CD27 defines phenotypically and functionally different human NK cell subsets

Mireille VOSSENMourad MatmatiKirsten M.L. HERTOGHSPaul A. BAARSMi-Ran GENTGeorges LeclercqJoerg HAMANNTaco W. KUIJPERSRene A.W. VAN LIER

A1 Journal Article in JOURNAL OF IMMUNOLOGY

EGF-TM7 receptors: a diverse and still evolving family of receptors on the leukocyte surface

Mourad MatmatiRené Van LierGeorges LeclercqJorg Hamann

Generation of T cells from human embryonic stem cells

Frank TimmermansImke VelgheLieve VanwalleghemMagda De SmedtStefanie Van CoppernolleGeorges LeclercqTom TaghonHarry MooreAnton W LangerakTessa Kerre et al.

Human intrathymic development: a selective approach

Jean PlumMagda De SmedtGeorges LeclercqTom TaghonTessa KerreBart Vandekerckhove

A1 Journal Article in SEMINARS IN IMMUNOPATHOLOGY

Ly49E-dependent inhibition of natural killer cells by urokinase plasminogen activator

Tina Van Den BroeckFrederick StevenaertSylvie TaveirneVeronique DebackerCHRISTEL VANGESTELBart VandekerckhoveTom TaghonPatrick MatthysJean PlumWerner Held et al.

A1 Journal Article in Blood

2007

Interactions of Ly49 family receptors with MHC class I ligands in trans and cis

L SCARPELLINOF OESCHGERP GUILLAUMEJD COUDERTF LEVYGeorges LeclercqW HELD

A1 Journal Article in JOURNAL OF IMMUNOLOGY

KLRG1 binds cadherins and preferentially associates with SHIP-1

MS TESSMERC FUGEREF STEVENAERTOV NAIDENKOHJ CHONGGeorges LeclercqL BROSSAY

A1 Journal Article in INTERNATIONAL IMMUNOLOGY

Mouse TCR alpha beta(+)CD8 alpha alpha intraepithelial lymphocytes express genes that down-regulate their antigen reactivity and suppress immune responses

TL DENNINGS GRANGERD MUCIDAR GRADDYGeorges LeclercqWG ZHANGK HONEYJP RASMUSSENH CHEROUTREAY RUDENSKY et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Notch signaling induces cytoplasmic CD3 epsilon expression in human differentiating NK cells

Magda De SmedtTom TaghonInge Van de WalleGreet De SmetGeorges LeclercqJean Plum

A1 Journal Article in BLOOD

T-, B- and NK-lymphoid, but not myeloid cells arise from human CD34+CD38-CD7+ common lymphoid progenitors expressing lymphoid-specific genes

Inge HoebekeMagda De SmedtFrank StolzK Pike-OverzetFJT StaalJean PlumGeorges Leclercq

A1 Journal Article in LEUKEMIA

2006

A unique LT alpha beta dependent pathway regulates thymic emigration of V alpha 14i NKT cells

Pieter DewintAnn-Sophie FrankiKatrien Van BenedenKirsten HammondStijn LambrechtGeorges LeclercqDieter DeforceMitchell KronenbergDirk Elewaut

A unique lymphotoxin alpha beta dependent pathway regulates thymic emigration of V alpha 14iNKT cells

Dirk ElewautAnn-Sophie FrankiKatrien Van BenedenPieter DewintKirstin HammondGeorges LeclercqDieter DeforceMitchell Kronenberg

A unique lymphotoxin alpha,beta-dependent pathway regulates thymic emigration of V alpha 14 invariant natural killer T cells

Ann-Sophie FrankiKatrien Van BenedenPieter DewintKJL HAMMONDStijn LambrechtGeorges LeclercqM KRONENBERGDieter DeforceDirk Elewaut

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of essential genes in human lymphopoieis

Inge HoebekeGeorges LeclercqJean Plum

IL-15 augments CD4+T-cell proliferation by inhibiting the suppressive function of CD25HighCD4+regulatory T-cells

Tom Van BelleTom BoonefaesGeorges LeclercqJohan Grooten

Overexpression of HES-1 is not sufficient to impose T-cell differentiation on human hernatopoietic stem cells

Inge HoebekeMagda De SmedtInge Van de WalleKatia ReynvoetGreet De SmetJean PlumGeorges Leclercq

A1 Journal Article in BLOOD

2005

Defective CD4(+)CD25(+) regulatory T cell functioning in collagen-induced arthritis: an important factor in pathogenesis, counter-regulated by endogenous IFN-gamma

H KELCHTERMANSB DE KLERCKT MITERAM VAN BALEND BULLENSA BILLIAUGeorges LeclercqP MATTHYS

A1 Journal Article in ARTHRITIS RESEARCH & THERAPY

Different thresholds of Notch signaling bias human precursor cells toward B-, NK-, monocytic/dendritic-, or T-cell lineage in thymus microenvironment

Magda De SmedtInge HoebekeKatia ReynvoetGeorges LeclercqJean Plum

A1 Journal Article in BLOOD

Ly49 and CD94/NKG2 receptor acquisition by NK cells does not require lymphotoxin-beta receptor expression

Frederik StevenaertKatrien Van BenedenVeerle De ColvenaerAnn-Sophie FrankiVeronique DebackerTom BoterbergDieter DeforceK PFEFFERJean PlumDirk Elewaut et al.

A1 Journal Article in BLOOD

Negative thymocyte selection to HERV-K18 superantigens in humans

F MEYLANMagda De SmedtGeorges LeclercqJean PlumO LEUPINS MARGUERATB CONRAD

A1 Journal Article in BLOOD

Tangeretin inhibits extracellular-signal-regulated kinase (ERK) phosphorylation

S VAN SLAMBROUCKVS PARMARSK SHARMAB DE BONDTF FOREP COOPMANBarbara VanhoeckeTom BoterbergHerman DepypereGeorges Leclercq et al.

A1 Journal Article in FEBS LETTERS

The role of surface receptors in differentiation of natural killer cells

Frederik StevenaertGeorges LeclercqJean Plum

2004

Notch receptor signaling and human T cell development.

Magda De SmedtKatia ReynvoetGeorges LeclercqJean Plum

Role of natural killer cells in the rejection process of corneal allografts in rats

Ilse ClaerhoutPhilippe KestelynVeronique DebackerHilde BeeleGeorges Leclercq

A1 Journal Article in TRANSPLANTATION

2003

Homeobox gene expression profile in human hematopoietic multipotent stem cells and T-cell progenitors: implications for human T-cell development

Tom TaghonK THYSMagda De SmedtF WEERKAMPFJT STAALJean PlumGeorges Leclercq

A1 Journal Article in LEUKEMIA

Ly49E expression points toward overlapping, but distinct, natural killer (NK) cell differentiation kinetics and potential of fetal versus adult lymphoid progenitors

Frederik StevenaertKatrien Van BenedenAn De CreusVeronique DebackerJean PlumGeorges Leclercq

A1 Journal Article in JOURNAL OF LEUKOCYTE BIOLOGY

2002

Active form of notch imposes T cell fate in human progenitor cells

Magda De SmedtKatia ReynvoetTessa KerreTom TaghonBruno VerhasseltBart VandekerckhoveGeorges LeclercqJean Plum

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Developmental and functional analysis of Vγ3 T lymphocytes and dendritic cells

An De CreusGeorges LeclercqJean Plum

Developmental and functional defects of thymic and epidermal V gamma 3 cells in IL-15-deficient and IFN regulatory factor-1-deficient mice.

An De CreusK VAN BENEDENFrederik StevenaertV DEBACKERJean PlumGeorges Leclercq

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Effects of tangeretin on human cell-cell interactions

Marc BrackeTom BoterbergHerman DepypereChristophe StoveGeorges LeclercqG VandecasteeleMarcus Mareel

Enforced expression of HOX-A10 drives human hematopoietic precursor cells toward the monocytic lineage

Tom TaghonF StolzMagda De SmedtM CnockaertBruno VerhasseltJean PlumGeorges Leclercq

Expression of inhibitory receptors Ly49E and CD94/NKG2 on fetal thymic and adult epidermal TCR V gamma 3 lymphocytes.

K VAN BENEDENAn De CreusFrederik StevenaertV DEBACKERJean PlumGeorges Leclercq

A1 Journal Article in JOURNAL OF IMMUNOLOGY

HOX en GATA : molecular control of human hematopoiesis

Tom TaghonGeorges LeclercqJean Plum

HOX-A10 regulates hematopoietic lineage commitment: evidence for a monocyte-specific transcription factor

Tom TaghonFrank StolzMagda De SmedtM CNOCKAERTBruno VerhasseltJean PlumGeorges Leclercq

A1 Journal Article in BLOOD

Induction of IL-15 by TCR/CD3 aggregation depends on IFN-gamma and protects against apoptosis of immature thymocytes in vivo.

P MATTHYSHans DoomsPieter RottiersT MITERAL OVERBERGHGeorges LeclercqA BILLIAUJohan Grooten

A1 Journal Article in CLINICAL AND EXPERIMENTAL IMMUNOLOGY

NK cells developing in vitro from fetal mouse progenitors express at least one member of the Ly49 family that is acquired in a time-dependent and stochastic manner independently of CD94 and NKG2.

KP FRASERF GAYSJH ROBINSONK VAN BENEDENGeorges LeclercqRE VANCEDH RAULETCG BROOKS

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Phenotypical and functional differentiation of natural killer cells and T cell receptor γδ cells

Katrien Van BenedenGeorges LeclercqJean Plum

Role of inhibitory NK receptors controlling thymic differentiation and functional activity of TCR Vgamma3 lymphocytes

Katrien Van BenedenFrederic StevenaertGeorges Leclercq

A2 Journal Article in MODERN ASPECTS OF IMMUNOBIOLOGY

The citrus methoxyflavone tangeretin affects human cell-cell interactions

marc brackeTom BoterbergHerman DepypereChristophe StoveGeorges LeclercqMarcus Mareel

A1 Journal Article in FLAVONOIDS IN CELL FUNCTION

2001

Enforced expression of GATA-3 severely reduces human thymic cellularity

Tom TaghonMagda De SmedtFrank StolzM CNOCKAERTJean PlumGeorges Leclercq

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Expression of Ly49E and CD94/NKG2 on fetal and adult NK cells.

K VAN BENEDENFrederik StevenaertAn De CreusV DEBACKERJ DE BOEVERJean PlumGeorges Leclercq

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Human B cell growth and differentiation in the spleen of immunodeficient mice.

Stany DepraetereL VERHOYEGeorges LeclercqGeert Leroux-Roels

A1 Journal Article in JOURNAL OF IMMUNOLOGY

2000

Human T lymphopoiesis - In vitro and in vivo study models.

Jean PlumM DE SMEDTBruno VerhasseltTessa KerreDominique VanheckeBart VandekerckhoveGeorges Leclercq

A1 Journal Article in NEUROIMMUNOMODULATION

Langerhans cells that have matured in vivo in the absence of T cells are fully capable of inducing a helper CD4 as well as a cytotoxic CD8 response

An De CreusKatrien Van BenedenTom TaghonFrank StolzVeronique DebackerJean PlumGeorges Leclercq

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Signals from the IL-9 receptor are critical for the early stages of human intrathymic T cell development.

M DE SMEDTBruno VerhasseltTessa KerreDominique VanheckeE NAESSENSGeorges LeclercqJC RENAULDJ VAN SNICKJean Plum

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Tangerine effects on human mammary cell interactions

Marc BrackeTom BoterbergGeorges LeclercqHerman DepypereMarcus Mareel

1999

In vitro intrathymic differentiation kinetics of human fetal liver CD34(+)CD38(-) progenitors reveals a phenotypically defined dendritic/T-NK precursor split

Jean PlumMagda De SmedtBruno VerhasseltFritz OffnerTessa KerreD VANHECKEGeorges LeclercqBart Vandekerckhove

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Murine fetal natural killer cells are functionally and structurally distinct from adult natural killer cells

Katrien Van BenedenAn De CreusVeronique DebackerJozef De BoeverJean PlumGeorges Leclercq

A1 Journal Article in JOURNAL OF LEUKOCYTE BIOLOGY

1997

Human thymocytes become lineage committed at an early postselection CD69(+) stage, before the onset of functional maturation.

Dominique VanheckeBruno VerhasseltM DE SMEDTGeorges LeclercqJean PlumBart Vandekerckhove

A1 Journal Article in JOURNAL OF IMMUNOLOGY

MHC class II molecules are required for initiation of positive selection but not during terminal differentiation of human CD4 single positive thymocytes

Dominique VanheckeBruno VerhasseltM DESMEDTB DEPAEPEGeorges LeclercqJean PlumBart Vandekerckhove

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Phenotypic and functional maturation of TCR gamma delta cells in the human thymus.

Fritz OffnerKatrien Van BenedenV DEBACKERDominique VanheckeBart VandekerckhoveJean PlumGeorges Leclercq

A1 Journal Article in JOURNAL OF IMMUNOLOGY

1996

Apoptose: dood voor het leven

Georges LeclercqJean Plum

A4 Journal Article in TIJDSCHRIFT VAN DE BELGISCHE VERENIGING VAN LABORATORIUM-TECHNOLOGEN = REVUE DE L'ASSOCIATION BELGE DES TECHNOLOGUES DE LABORATOIRE

Differential effects of interleukin-15 and interleukin-2 on differentiation of bipotential T/natural killer progenitor cells.

Georges LeclercqV DEBACKERM DESMEDTJean Plum

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Interleukin-7 is a critical growth factor in early human T-cell development.

Jean PlumM DESMEDTGeorges LeclercqBruno VerhasseltBart Vandekerckhove

A1 Journal Article in BLOOD

Thymic and extrathymic T cell development.

Georges LeclercqJean Plum

A1 Journal Article in LEUKEMIA

Thymic development of Vγ3 cells

Georges LeclercqJean Plum

A2 Journal Article in SEMINARS IN IMMUNOLOGY

1995

Apoptose: dood voor het leven

Georges LeclercqJean Plum

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Characterization of distinct stages during the differentiation of human CD69+CD3+thymocytes and identification of thymic emigrants

Dominique VanheckeGeorges LeclercqJean PlumBart Vandekerckhove

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Cytokine dependence of V(gamma)3 thymocytes - mature but not immature V(gamma)3 cells require endogenous IL-2 and IL-7 to survive. Evidence for cytokine redundancy.

Georges LeclercqM DESMEDTJean Plum

A1 Journal Article in INTERNATIONAL IMMUNOLOGY

Differentiation to T helper cells in the thymus : gradual acquisition of T helper cell function by CD3⁺CD4⁺ cells

Dominique VanheckeBruno VerhasseltVeronique DebackerGeorges LeclercqJean PlumBart Vandekerckhove

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Expression and function of Fc receptors in the thymus.

Georges LeclercqJean Plum

A1 Journal Article in CRITICAL REVIEWS IN IMMUNOLOGY

INFLUENCE OF TGF-BETA ON MURINE THYMOCYTE DEVELOPMENT IN FETAL THYMUS ORGAN-CULTURE.

Jean PlumM DESMEDTGeorges LeclercqBart Vandekerckhove

A1 Journal Article in JOURNAL OF IMMUNOLOGY

STIMULATION OF TCR V-GAMMA-3 CELLS BY GRAM-NEGATIVE BACTERIA.

Georges LeclercqJean Plum

A1 Journal Article in JOURNAL OF IMMUNOLOGY

1994

DEVELOPMENTALLY ORDERED APPEARANCE OF A FUNCTIONAL FC-GAMMA RECEPTOR ON TCR V-GAMMA-3 THYMOCYTES - EVIDENCE FOR STIMULATION-INDUCED EXPRESSION.

Georges LeclercqJean Plum

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Human CD34+ Fetal Liver Stem Cells Differentiate to T Cells in a Mouse Thymic Microenvironment.

Jean PlumM DESMEDTMP DEFRESNEGeorges LeclercqBart Vandekerckhove

A1 Journal Article in BLOOD

Human Fetal Liver Cells differentiate into thymocytes in chemeric mouse Fetal Thymus Organ Culture

M DE SMEDTGeorges LeclercqBart VandekerckhoveJean Plum

Human fetal liver cells differentiate into thymocytes in chimeric mouse fetal thymus organ culture

Magda De SmedtGeorges LeclercqBart VandekerckhoveJean Plum

Stem cell differentiation into mature lymphocytes using the SCID mouse thymus chimera model

Magda De SmedtGeorges LeclercqBart VandekerckhoveJean Plum

Bookchapter in Hematopoietic stem cells : the Mulhouse manual

Thymocyte Differentiation is accompanied by modulation of multiple human adhesion antigens

D VAN HECKEGeorges LeclercqJean PlumBart Vandekerckhove

1993

EXOGENOUS IL-7 PROMOTES THE GROWTH OF CD3-CD4-CD8-CD44+CD25+/- PRECURSOR CELLS AND BLOCKS THE DIFFERENTIATION PATHWAY OF TCR-ALPHA-BETA CELLS IN FETAL THYMUS ORGAN-CULTURE.

Jean PlumM DESMEDTGeorges Leclercq

A1 Journal Article in JOURNAL OF IMMUNOLOGY

INTRATHYMIC DIFFERENTIATION OF V-GAMMA-3 T-CELLS.

Georges LeclercqJean PlumD NANDIM DESMEDTJP ALLISON

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

1992

CYTOKINE PRODUCTION AND RESPONSIVENESS OF FETAL T-CELL RECEPTOR V-GAMMA-3 THYMOCYTES.

Georges LeclercqM DESMEDTJean Plum

A1 Journal Article in SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Cytokines and T cell development in fetal thymus organ culture

Presence of CD8a-CD8ß-positive TcRy/5 thymocytes in the fetal murine thymus and their in vitro expansion with interleukin-7.

Georges LeclercqM DESMEDTJean Plum

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

1991

IFN-GAMMA REVERSES IL-4 INHIBITION OF FETAL THYMUS GROWTH IN ORGAN-CULTURE

Jean PlumMieke DesmedtA BILLIAUH HEREMANSGeorges LeclercqB TISON

A1 Journal Article in JOURNAL OF IMMUNOLOGY

INTERLEUKIN-2 STIMULATED T-CELL RECEPTOR V-GAMMA-3 POSITIVE THYMOCYTES DO NOT MIGRATE TO THE SKIN

Georges LeclercqM DESMEDTJean Plum

A1 Journal Article in IMMUNOLOGY LETTERS

INTERLEUKIN-4 INDUCES CD8-ALPHA EXPRESSION ON T-CELL RECEPTOR V-GAMMA-5 THYMOCYTES

Georges LeclercqMagda De SmedtJean Plum

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

1990

Direct evidence for partial target specificity in lymphokine-activated killer thymocytes

Georges LeclercqMagda De SmedtJean Plum

A1 Journal Article in SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Enhancement of granulocyte luminescence by murine macrophage secretory products : suggestive evidence for the release of a new activator

Jean WillemsGeorges LeclercqMarcel Joniau

A1 Journal Article in JOURNAL OF BIOLUMINESCENCE AND CHEMILUMINESCENCE

Expansion of large granular lymphocytes in IL-2-driven 14-day-old fetal thymocytes in organ culture

Jean PlumFrits KoningGeorges LeclercqBernard TisonMagda De Smedt

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Inhibitory effect of murine recombinant IL-4 on thymocyte development in fetal thymus organ cultures

Jean PlumMagda De SmedtGeorges LeclercqBernard Tison

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Preferential proliferation of T cell receptor Vγ3-positive cells in IL-2-stimulated fetal thymocytes

Georges LeclercqMagda De SmedtBernard TisonJean Plum

A1 Journal Article in JOURNAL OF IMMUNOLOGY

1989

Analysis of the cytotoxic function of the thymocytes generated in a 14-day old mouse fetal thymus organ culture with high dose of IL-2

Georges LeclercqM De SmedtB TisonJean Plum

A1 Journal Article in THYMUS

Influence of antibodies neutralizing cytokines on murine fetal thymic organ cultures

Jean PlumM De SmedtB TisonGeorges Leclercq

A1 Journal Article in THYMUS

1988

Enhanced oxygen metabolism of peritoneal macrophages in the presence of murine neuroblastoma cells is partly caused by enkephalins

Jean WillemsGeorges LeclercqMarcel Joniau

A1 Journal Article in JOURNAL OF NEUROIMMUNOLOGY

Enkephalins can modulate the release of superoxide from resident murine peritoneal macrophages

J WillemsGeorges LeclercqM Joniau

1987

Cellular immunity changes caused by LDH virus: analogy with observations on neuroblastoma-bearing mice

Georges LeclercqJean WillemsHubertine HeremansJean-Paul CoutelierAlfons BilliauMarcel Joniau

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

Cellular immunity in neuroblastoma-bearing mice: evidence for changes associated with LDH virus

Georges LeclercqJ WillemsM Joniau

Enkephalin-induced release of reative oxygen intermediates from murine macrophages

J WillemsGeorges LeclercqM Joniau

Immune response to murine neuroblastoma: effects of in vitro culture of the tumor

Jean WillemsGeorges LeclercqMarcel Joniau

A1 Journal Article in JOURNAL OF NEUROIMMUNOLOGY

NK activity in neuroblastoma bearing mice: in vivo versus in vitro propagated tumor variants

Georges LeclercqJean WillemsMarcel Joniau

A1 Journal Article in JOURNAL OF CLINICAL & LABORATORY IMMUNOLOGY

Spontaneous chemiluminescence of peritoneal macrophages from neuroblastoma-bearing A/J mice : possible effect of endogenous opioid peptides

J WILLEMSGeorges LeclercqM JONIAU

1986

Immune response to murine neuroblastoma: effects of in vitro culture of the tumor: mitogen and mixed lymphocyte culture responses, interleukin 2 production, suppression and natural killer activity

Georges LeclercqJean WillemsMarcel Joniau

A1 Journal Article in JOURNAL OF CLINICAL & LABORATORY IMMUNOLOGY

1985

Chemiluminescence assay of phagocyte activity in mice bearing neuroblastoma : effect of in vitro culture of the tumor

Jean WillemsGeorges LeclercqMarcel Joniau

A1 Journal Article in CELL BIOLOGY INTERNATIONAL REPORTS

1983

Determination of immune complexes as measured by chemiluminescence of stimulated murine phagocytes: comparison with other quantification methods

J WillemsM JoniauGeorges Leclercq

Developmentally Ordered Appearance of a Functional Fey Receptor on TCR VY3 Thymocytes. J. Immunol., 1994, 153, 6, 2429-2435.

Georges LeclercqJean Plum

A2 Journal Article