Research Explorer

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Researcher

Geertrui Denecker

Awards & Distinctions

72 Results

2023

SOX11 regulates SWI/SNF complex components as member of the adrenergic neuroblastoma core regulatory circuitry

Bieke DecaestekerAmber LouwagieSiebe LoontiensFanny De VloedSarah-Lee BekaertJuliette RoelsSuzanne VanhauwaertSara De BrouwerEllen SandersA Berezovskaya et al.

A1 Journal Article in NATURE COMMUNICATIONS

2019

17q gain provides proliferative advantage to human embryonic stem cells under replicative stress

Liselot MusStéphane Van HaverGeertrui DeneckerNadja ZeltnerYudelca OgandoEllen SandersEva JacobsMina PopovicChristophe Van NesteSuzanne Vanhauwaert et al.

SOX11 as mediator of the adrenergic cell state in NB

Bieke DecaestekerAmber LouwagieSara De BrouwerVolodimir OlexioukGeertrui DeneckerCarolina de Carvalho NunesKaren VerboomMoritz GartlgruberWouter Van LoockeElena Afanasyeva et al.

SOX11 is a key epigenetic regulator in the adrenergic MYCN amplified neuroblastoma

Amber LouwagieBieke DecaestekerSara De BrouwerGeertrui DeneckerCarolina de Carvalho NunesVolodimir OlexioukKaren VerboomMoritz GartlgruberWouter Van LoockeElena Afanasyeva et al.

SOX11 is a key epigenetic regulator in the adrenergic MYCN amplified neuroblastoma

Amber LouwagieBieke DecaestekerCarolina de Carvalho NunesGeertrui DeneckerVolodimir OlexioukKaren VerboomMoritz GartlgruberWouter Van LoockeElena AfanasyevaPauline Depuydt et al.

2018

Exploring the contribution of gene dosage effects of 17Q gain on ESC and neuroblastoma proliferation

Liselot MusGeertrui DeneckerNadja ZeltnerYudelca OgandoStéphane Van HaverEllen SandersEva JacobsMina PopovicChristophe Van NesteSuzanne Vanhauwaert et al.

Exploring the contribution of gene dosage effects of 17q gain on ESC and neuroblastoma proliferation

Liselot MusGeertrui DeneckerNadja ZeltnerYudelca OgandoStéphane Van HaverEllen SandersEva JacobsMina PopovicChristophe Van NesteSuzanne Vanhauwaert et al.

Exploring the contribution of gene dosage effects of 17q gain on ESC and neuroblastoma proliferation

Liselot MusGeertrui DeneckerNadja ZeltnerYudelca OgandoStéphane Van HaverEllen SandersEva JacobsMina PopovicChristophe Van NesteSuzanne Vanhauwaert et al.

In silico discovery of a FOXM1 driven embryonal signaling pathway in therapy resistant neuroblastoma tumors

Suzanne VanhauwaertBieke DecaestekerSara De BrouwerCarina LeonelliKaat DurinckPieter MestdaghJo VandesompeleKaren SermonGeertrui DeneckerChristophe Van Neste et al.

A1 Journal Article in SCIENTIFIC REPORTS

SOX11 is a transcriptional circuit dosage sensitive transcription factor controlling SWI/SNF components

Bieke DecaestekerSara De BrouwerGeertrui DeneckerFanny De VloedWouter Van LoockeSuzanne VanhauwaertPauline DepuydtMoritz GartlgruberJolien De WynGenevieve Laureys et al.

TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets

Bieke DecaestekerGeertrui DeneckerChristophe Van NesteEmmy M DolmanWouter Van LoockeMoritz GartlgruberCarolina de Carvalho NunesFanny De VloedPauline DepuydtKaren Verboom et al.

A1 Journal Article in NATURE COMMUNICATIONS

TBX2 is implicated in cell cycle control and proliferation in neuroblastoma

Bieke DecaestekerGeertrui DeneckerChristophe Van NesteFanny De VloedMoritz GartlgruberPauline DepuydtWouter Van LoockeShana ClaeysDries RombautSiebe Loontiens et al.

The RRM2-PHF6 complex protects neuroblastoma cells from DNA damage accumulation to install a replication stress resistance phenotype

Carolina de Carvalho NunesKaat DurinckLisa DepestelSiebe LoontiensLouis DelhayeSofia ZanottiEmmy DolmanAline EggermontBieke DecaestekerPauline Depuydt et al.

The core regulatory circuit component TBX2 is implicated in cell cycle control and proliferation in neuroblastoma

Bieke DecaestekerGeertrui DeneckerChristophe Van NesteFanny De VloedMoritz GartlgruberPauline DepuydtWouter Van LoockeShana ClaeysDries RombautSiebe Loontiens et al.

The core regulatory circuit component TBX2 is implicated in cell cycle control and proliferation in neuroblastoma

Bieke DecaestekerGeertrui DeneckerWouter Van LoockeMoritz GartlgruberPauline DepuydtFanny De VloedShana ClaeysDries RombautSiebe LoontiensAnton Henssen et al.

Vehicle development, pharmacokinetics and toxicity of the anti-invasive agent 4-fluoro-3’,4’,5’-trimethoxychalcone in rodents

Liselot MusGeertrui DeneckerFranki SpelemanBart Roman

A1 Journal Article in PLOS ONE

2017

Early and late effects of pharmacological ALK inhibition on the neuroblastoma transcriptome

Shana ClaeysGeertrui DeneckerRobrecht CannoodtCandy KumpsKaat DurinckFranki SpelemanKatleen De Preter

A1 Journal Article in ONCOTARGET

Elevated ΔNp63α levels facilitate epidermal and biliary oncogenic transformation

Michael DevosBarbara GilbertGeertrui DeneckerKirsten LeursConor Mc GuireKelly LemeireTino HochepiedMarnik VuylstekeJo LambertCaroline Van den Broecke et al.

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

HBP1 is a negative epigenetic regulator of MYCN-driven neuroblastoma through interaction with the PRC2 complex

Shana ClaeysGeertrui DeneckerIrina LambertzEls JanssensSuzanne VanhauwaertBieke DecaestekerTom Van MaerkenBram De WildeGenevieve LaureysKristina Althoff et al.

RRM2 is an essential and druggable component of the FOXM1 driven replicative stress DNA damage response in neuroblastoma

Carolina de Carvalho NunesSiebe LoontiensPauline DepuydtSuzanne VanhauwaertBieke DecaestekerBram De WildeKatleen De PreterGeertrui DeneckerChristophe Van NesteKaat Durinck et al.

RRM2 is an essential and druggable component of the FOXM1 driven replicative stress DNA damage response in neuroblastoma

Carolina de Carvalho NunesSiebe LoontiensPauline DepuydtSuzanne VanhauwaertBieke DecaestekerBram De WildeKatleen De PreterGeertrui DeneckerChristophe Van NesteKaat Durinck et al.

SOX11 acts as part of the MYCN-WEE1 regulatory protein complex implicated in neuroblastoma

Bieke DecaestekerSara De BrouwerFanny De VloedGeertrui DeneckerSuzanne VanhauwaertJolien De WynGenevieve LaureysBjörn MentenPauline DepuydtJo Vandorpe et al.

The ETV5 oncogene is a target of activated ALK signaling in neuroblastoma

Liselot MusIrina LambertzCandy KumpsShana ClaeysGeertrui DeneckerWouter Van LoockeChristophe Van NesteJan KosterRogier VersteegNadine Van Roy et al.

The ETV5 oncogene is a target of activated ALK signaling in neuroblastoma

Liselot MusIrina LambertzCandy KumpsShana ClaeysGeertrui DeneckerWouter Van LoockeChristophe Van NesteJan KosterRogier VersteegNadine Van Roy et al.

The ETV5 oncogene is a target of activated ALK signaling in neuroblastoma

Liselot MusIrina LambertzCandy KumpsShana ClaeysGeertrui DeneckerWouter Van LoockeChristophe Van NesteJan KosterRogier VersteegNadine Van Roy et al.

The HBP1 tumor suppressor is a negative epigenetic regulator of MYCN driven neuroblastoma through interaction with the PRC2 complex

Geertrui DeneckerShana ClaeysIrina LambertzEls JanssensSuzanne VanhauwaertBieke DecaestekerTom Van MaerkenBram De WildeGenevieve LaureysKristina Althoff et al.

The HBP1 tumour suppressor is a negative epigenetic regulator of MYCN-driven neuroblastoma through interaction with the PRC2 complex

Shana ClaeysGeertrui DeneckerBieke DecaestekerEls JanssensCandy KumpsSara De BrouwerIrina LambertzAnnelies FieuwSuzanne VanhauwaertKristina Althoff et al.

The core regulatory circuit component TBX2 is implicated in cell cycle control and proliferation in neuroblastoma

Bieke DecaestekerGeertrui DeneckerWouter Van LoockeMoritz GartlgruberPauline DepuydtFanny De VloedShana ClaeysDries RombautSiebe LoontiensAnton Henssen et al.

2016

The TBX2 super-enhancer marked transcription factor on 17q is overexpressed in neuroblastoma and infers poor prognosis

Bieke DecaestekerFanny De VloedSiebe LoontiensGeertrui DeneckerWouter Van LoockeMoritz GartlgruberDries RombautAnneleen BeckersShana ClaeysAnton Henssen et al.

2014

Deregulation of the replisome factor MCMBP prompts oncogenesis in colorectal carcinomas through chromosomal instability

Mauricio Quimbaya GomezEric RaspéGeertrui DeneckerBram De CraeneRia RoelandtWim DeclercqXavier SagaertLieven De VeylderGeert Berx

A1 Journal Article in NEOPLASIA

Epidermal Snail expression drives skin cancer initiation and progression through enhanced cytoprotection, epidermal stem/progenitor cell expansion and enhanced metastatic potential

Bram De CraeneGeertrui DeneckerPetra VermassenJoachim TaminauC MauchAnnie DeroreJ JonkersE FuchsGeert Berx

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Identification of a ZEB2-MITF-ZEB1 transcriptional network that controls melanogenesis and melanoma progression

Geertrui DeneckerNiels VandammeOzden AkayD KoludrovicJoachim TaminauKelly LemeireAlexander GheldofBram De CraeneMireille Van GeleLieve Brochez et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2013

Caspase-14-deficient mice are more prone to the development of parakeratosis

Esther HosteGeertrui DeneckerBarbara GilbertFilip Van NieuwerburghLeslie van der FitsBob AsselberghRiet De RyckeJean-Pierre HachemDieter DeforceErrol P Prens et al.

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

Compound A, a selective glucocorticoid receptor modulator, enhances heat shock protein Hsp70 gene promoter activation

Ilse BeckZuzanna DrebertRuben Hoya-AriasAli A BaharMichael DevosDorien ClarisseSofie DesmetNadia BougarneBart RuttensValerie Gossye et al.

A1 Journal Article in PLOS ONE

2011

Caspase-14 is required for filaggrin degradation to natural moisturizing factors in the skin

Esther HostePatrick KempermanMichael DevosGeertrui DeneckerSanja KezicNico YauBarbara GilbertSaskia LippensPhilippe De GrooteRia Roelandt et al.

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

Cop1 constitutively regulates c-Jun protein stability and functions as a tumor suppressor in mice

Domenico MiglioriniSven BogaertsDieter DefeverRajesh VyasGeertrui DeneckerEnrico RadaelliAleksandra ZwolinskaVanessa DepaepeTino HochepiedWilliam C Skarnes et al.

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

2010

Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death

Panagiota A SotiropoulouAurelie CandiGuilhem MascreSarah De ClercqKhalil Kass YoussefGaelle LapougeEllen DahlClaudio SemeraroGeertrui DeneckerJean-Christophe Marine et al.

A1 Journal Article in NATURE CELL BIOLOGY

Monoallelic but not biallelic loss of Dicer1 promotes tumorigenesis in vivo

Irina LambertzDavid NittnerPieter MestdaghGeertrui DeneckerJo VandesompeleMA DyerJean-Christophe Marine

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Widespread overexpression of epitope-tagged Mdm4 does not accelerate tumor formation in vivo

Sarah De ClercqAgniezska GembarskaGeertrui DeneckerMarion MaetensMichaël NaessensKatharina HaighJody HaighJean-Christophe Marine

A1 Journal Article in MOLECULAR AND CELLULAR BIOLOGY

2009

The "Caveolae Brake Hypothesis" and the Epidermal Barrier

Truus RoelandtChristina GiddeloCarol HeughebaertGeertrui DeneckerMelanie HupeDebra CrumrineAndy KusumaMarek HaftekDiane RosseeuwWim Declercq et al.

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

2008

Caspase-14 reveals its secrets

Geertrui DeneckerPetra OvaerePeter VandenabeeleWim Declercq

A1 Journal Article in JOURNAL OF CELL BIOLOGY

2007

Caspase-14 protects against epidermal UVB photo-damage and water loss.

Geertrui DeneckerEsther HosteBarbara GilbertTino HochepiedPetra OvaereSaskia LippensC VAN DEN BROUCKEPetra Van DammeKatharina D'HerdeJ HACHEM et al.

Caspase-14 protects against epidermal UVB photodamage and water loss

Geertrui DeneckerEsther HosteBarbara GilbertTino HochepiedPetra OvaereSaskia LippensCaroline Van den broeckePetra Van DammeKatharina D'HerdeJP HACHEM et al.

A1 Journal Article in NATURE CELL BIOLOGY

2006

Macrophages use different internalization mechanisms to clear apoptotic and necrotic cells

Dmitri KryskoGeertrui DeneckerNele FestjensSofie GabriëlsEef ParthoensKatharina D'HerdePeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Necrosis is associated with IL-6 production but apoptosis is not

Tom Vanden BergheMichaël KalaiGeertrui DeneckerAnn MeeusXavier SaelensPeter Vandenabeele

A1 Journal Article in CELLULAR SIGNALLING

Role of caspase-14 in terminal differentiation of keratinocytes

Geertrui DeneckerEsther HosteBarbara GilbertTino HochepiedPetra OvaereSaskia LippensCaroline VandenbrouckeKatharina D'HerdePeter VandenabeeleWim Declercq

The secret life of caspase-14

Geertrui DeneckerEsther HosteT HOCHPIEDBarbara GilbertPetra OvaereKatharina D'HerdeCaroline VandenbrouckeSaskia LippensLore SchoonjansClaude Libert et al.

2005

A novel caspase-2 complex containing TRAF2 and RIP1

Mohamed LamkanfiKathleen D'HondtLieselotte Vande WalleMarjan Van GurpGeertrui DeneckerJill DemeulemeesterMichaël KalaiWim DeclercqXavier SaelensPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Death penalty for keratinocytes: apoptosis versus cornification

Saskia LippensGeertrui DeneckerPetra OvaerePeter VandenabeeleWim Declercq

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2004

INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1 beta generation

Mohamed LamkanfiGeertrui DeneckerMichaël KalaiKathleen D'HondtAnn MeeusWim DeclercqXavier SaelensPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

More than one way to die: methods to determine TNF-induced apoptosis and necrosis

Tom Vanden BergheGeertrui DeneckerGreet BrouckaertDmitri KryskoKatharina D'HerdePeter Vandenabeele

A4 Journal Article in METHODS IN MOLECULAR MEDICINE

Targeting Rac1 by the Yersinia effector protein YopE inhibits caspase-1-mediated maturation and release of interleukin-1 beta

Peter SchotteGeertrui DeneckerAeke Van Den BroekePeter VandenabeeleGR CORNELISRudi Beyaert

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Vitamin D3 induces caspase-14 expression in psoriatic lesions and enhances caspase-14 processing in organotypic skin cultures

Saskia LippensM KOCKXGeertrui DeneckerM KNAAPENA VERHEYENR CHRISTIAENE TSCHACHLERPeter VandenabeeleWim Declercq

A1 Journal Article in AMERICAN JOURNAL OF PATHOLOGY

2003

Regulation of the expression and processing of caspase-12

Michaël KalaiMohamed LamkanfiGeertrui DeneckerM BoogmansSaskia LippensAnn MeeusWim DeclercqPeter Vandenabeele

A1 Journal Article in JOURNAL OF CELL BIOLOGY

2001

Activated caspase-1 is not a central mediator of inflammation in the course of ischemia-reperfusion.

M DAEMENGeertrui DeneckerC VAN'T VEERT WOLFSPeter VandenabeeleWA BUURMAN

A1 Journal Article in TRANSPLANTATION

Apoptotic and necrotic cell death induced by death domain receptors.

Geertrui DeneckerD VERCAMMENWim DeclercqPeter Vandenabeele

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Death receptor-induced apoptotic and necrotic cell death: differential role of caspases and mitochondria.

Geertrui DeneckerD VERCAMMENMargino SteemansTom Vanden BergheGreet BrouckaertGeert van LooB ZHIVOTOVSKYWalther FiersJohan GrootenWim Declercq et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Different pathways mediate cytochrome c release after photodynamic therapy with hypericin.

A VANTIEGHEMY XUPeter VandenabeeleGeertrui DeneckerJR VANDENHEEDEW MERLEVEDEPA DE WITTEP AGOSTINIS

A1 Journal Article in PHOTOCHEMISTRY AND PHOTOBIOLOGY

Yersinia enterocolitica YopP-induced apoptosis of macrophages involves the apoptotic signaling cascade upstream of Bid.

Geertrui DeneckerWim DeclercqC GEUIJENA BOLANDR BENABDILLAHMarjan Van GurpMP SORYPeter VandenabeeleGR CORNELIS

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2000

A role for potassium in TNF-induced apoptosis and gene-induction in human and rodent tumour cell lines.

LC PENNINGGeertrui DeneckerD VERCAMMENWim DeclercqRG SCHIPPERPeter Vandenabeele

A1 Journal Article in CYTOKINE

Functional protection by acute phase proteins alpha(1)-acid glycoprotein and alpha(1)-antitrypsin against ischemia/reperfusion injury by preventing apoptosis and inflammation.

M DAEMENVH HEEMSKERKC VAN 'T VEERGeertrui DeneckerTGAM WOLFSPeter VandenabeeleWA BUURMAN

A1 Journal Article in CIRCULATION

Identification and characterization of a novel cell cycle-regulated internal ribosome entry site.

Sigrid CornelisY BRUYNOOGHEGeertrui DeneckerSofie Van HuffelSandrine TintonRudi Beyaert

A1 Journal Article in MOLECULAR CELL

Phosphatidyl serine exposure during apoptosis precedes release of cytochrome c and decrease in mitochondrial transmembrane potential.

Geertrui DeneckerHans DoomsGeert van LooD VERCAMMENJohan GrootenWalther FiersWim DeclercqPeter Vandenabeele

A1 Journal Article in FEBS LETTERS

1999

Activation of caspases in lethal experimental hepatitis and prevention by acute phase proteins.

Wim Van MolleGeertrui DeneckerI RODRIGUEZPeter BrouckaertPeter VandenabeeleClaude Libert

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Inhibition of Tumor Necrosis Factor-induced necrotic cell death by the zinc finger protein A20.

Karen HeyninckGeertrui DeneckerDirk De ValckWalther FiersRudi Beyaert

A1 Journal Article in ANTICANCER RESEARCH

Inhibition of apoptosis induced by ischemia-reperfusion prevents inflammation.

M DAEMENC VAN'T VEERGeertrui DeneckerVH HEEMSKERKT WOLFSM CLAUSSPeter VandenabeeleWA BUURMAN

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

1998

Cooperation of both TNF receptors in inducing apoptosis: Involvement of the TNF receptor-associated factor binding domain of the TNF receptor 75.

Wim DeclercqGeertrui DeneckerWalther FiersPeter Vandenabeele

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Dual signaling of the Fas receptor: Initiation of both apoptotic and necrotic cell death pathways.

Dominique VercammenGreet BrouckaertGeertrui DeneckerMarc Van De CraenWim DeclercqWalther FiersPeter Vandenabeele

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor.

Dominique VercammenRudi BeyaertGeertrui DeneckerVera GoossensGeert van LooWim DeclercqJohan GrootenWalther FiersPeter Vandenabeele

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

1997

Cleavage of PITSLRE kinases by ICE/CASP-1 and CPP32/CASP-3 during apoptosis induced by tumor necrosis factor.

Rudi BeyaertVJ KIDDSigrid CornelisM VANDECRAENGeertrui DeneckerJM LAHTIR GURURAJANPeter VandenabeeleWalther Fiers

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Differential role of calcium in tumour necrosis factor-mediated apoptosis and secretion of granulocyte-macrophage colony-stimulating factor in a T cell hybridoma.

Geertrui DeneckerPeter VandenabeeleJohan GrootenLC PENNINGWim DeclercqRudi BeyaertWA BUURMANWalther Fiers

A1 Journal Article in CYTOKINE

1996

TNF-induced intracellular signaling leading to gene induction or to cytotoxicity by necrosis or by apoptosis.

Walther FiersRudi BeyaertElke BooneSigrid CornelisWim DeclercqEls DecosterGeertrui DeneckerBart DepuydtDirk De ValckG DEWILDE et al.

A1 Journal Article in JOURNAL OF INFLAMMATION