Research Explorer

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Researcher

Geert Leroux-Roels

Awards & Distinctions

405 Results

2023

A human monoclonal antibody against HBsAg for the prevention and treatment of chronic HBV and HDV infection

Rani BurmFreya Van HoutteLieven VerhoyeAhmed Atef Ahmed Abouzeid MesalamS CiesekP RoingeardH WedemeyerGeert Leroux-RoelsPhilip Meuleman

A1 Journal Article in JHEP REPORTS

Double-blind, placebo-controlled, dose-escalating study evaluating the safety and immunogenicity of an epitope-specific chemically defined nanoparticle RSV vaccine

Isabel Leroux-RoelsJacques BruhwylerLilli StergiouMark SumerayJasper JoyeCathy MaesPaul-Henri LambertGeert Leroux-Roels

A1 Journal Article in VACCINES

Harmonization of cellular immunoassays for the evaluation of influenza vaccine immunogenicity

Gwenn WaerlopIsabel Leroux-RoelsGeert Leroux-Roels

Human immunity and susceptibility to influenza A(H3) viruses of avian, equine, and swine origin

Elien VandoornWojciech StadejekIsabel Leroux-RoelsGeert Leroux-RoelsAnna ParysKristien Van Reeth

A1 Journal Article in EMERGING INFECTIOUS DISEASES

Immune responses in healthy adults elicited by a bivalent norovirus vaccine candidate composed of GI.4 and GII.4 VLPs without adjuvant

Gwenn WaerlopYorick JanssensBart JacobsFranziska JarczowskiAndré DiessnerGeert Leroux-RoelsVictor KlimyukIsabel Leroux-RoelsFrank Thieme

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Immunogenicity, safety, and preliminary efficacy evaluation of OVX836, a nucleoprotein-based universal influenza A vaccine candidate : a randomised, double-blind, placebo-controlled, phase 2a trial

Isabel Leroux-RoelsPaul WillemsGwenn WaerlopYorick JanssensJessika TourneurFIEN DE BOEVERJacques BruhwylerAzhar AlhatemiBart JacobsFlorence Nicolas et al.

A1 Journal Article in LANCET INFECTIOUS DISEASES

2022

A randomized, double-blind, placebo-controlled, dose-escalating phase I trial to evaluate safety and immunogenicity of a plant-produced, bivalent, recombinant norovirus-like particle vaccine

Isabel Leroux-RoelsCathy MaesJasper JoyeBart JacobsFranziska JarczowskiAndré DiessnerYorick JanssensGwenn WaerlopKirsi TamminenSuvi Heinimäki et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Characterization of the cell-mediated immune response to Takeda’s live-attenuated tetravalent dengue vaccine in adolescents participating in a phase 2 randomized controlled trial conducted in a dengue-endemic setting

Vianney TricouRaphael GottardoMichael A. EganFrédéric ClementGeert Leroux-RoelsXavier Sáez-LlorensAstrid BorkowskiDerek WallaceHansi J. Dean

A1 Journal Article in VACCINE

Harmonization and qualification of an IFN-γ Enzyme-Linked ImmunoSpot assay (ELISPOT) to measure influenza-specific cell-mediated immunity within the FLUCOP consortium

Gwenn WaerlopGeert Leroux-RoelsTeresa LambeDuncan BellamyDonata MedagliniElena PettiniRebecca Jane CoxMai-Chi TrieuRichard DaviesGeir Bredholt et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Harmonization and qualification of intracellular cytokine staining to measure influenza-specific CD4+ T cell immunity within the FLUCOP consortium

Sarah BegueGwenn WaerlopBruno SalaunMichel JanssensDuncan BellamyRebecca Jane CoxRichard DaviesElena GianchecchiDonata MedagliniEmanuele Montomoli et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Randomized, double-blind, reference-controlled, phase 2a study evaluating the immunogenicity and safety of OVX836, a nucleoprotein-based influenza vaccine

Isabel Leroux-RoelsGwenn WaerlopJessika TourneurFIEN DE BOEVERCatherine MaesJacques BruhwylerDelphine Guyon-GellinPhilippe MorisJudith Del CampoPaul Willems et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Safety and immunogenicity of mRNA-LNP COVID-19 vaccine CVnCoV in Latin American adults: A phase 2 randomized study

Xavier Saez-LlorensClaudio LanataElaine ArangurenCarlos R. CelisRubelio CornejoRodrigo DeAntonioLucie EckerDiegi GarridoAna I. GilMarina Gonzales et al.

U Journal Article in VACCINE: X

The role of cell-mediated immunity against influenza and its implications for vaccine evaluation

Yorick JanssensJasper JoyeGwenn WaerlopFrédéric ClementGeert Leroux-RoelsIsabel Leroux-Roels

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

2021

A role for B cells to transmit hepatitis C virus infection

Isabelle DesombereFreya Van HoutteAliasghar Farhoudi MoghadamLieven VerhoyeCaroline BuysschaertYvonne GijbelsSibyl CouventW SwinnenHans Van VlierbergheAndré Elewaut et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Immunogenicity and safety of a 3-antigen hepatitis B vaccine vs a single-antigen hepatitis B vaccine : a phase 3 randomized clinical trial

T VesikariA FinnP van DammeIsabel Leroux-RoelsGeert Leroux-RoelsN SegallA TomaG VallieresR AronsonD Reich et al.

A1 Journal Article in JAMA NETWORK OPEN

Immunogenicity and safety of a tri-antigenic versus a mono-antigenic hepatitis B vaccine in adults (PROTECT) : a randomised, double-blind, phase 3 trial

T VesikariJM LangleyN SegallBJ WardC CooperG PoliquinB SmithS GanttJE McElhaneyM Dionne et al.

A1 Journal Article in LANCET INFECTIOUS DISEASES

Long-term immunogenicity and safety of a non-typeable Haemophilus influenzae-Moraxella catarrhalis vaccine : 4-year follow-up of a phase 1 multicentre trial

Philippe De SmedtGeert Leroux-RoelsCorinne VandermeulenAnnaelisa TasciottiGennaro Di MaroMarie DozotDaniela CasulaMargherita AnnaratoneDaniele RiccucciAshwani Kumar Arora

A2 Journal Article in VACCINE: X

Proof-of-concept of a low-dose unmodified mRNA-based rabies vaccine formulated with lipid nanoparticles in human volunteers : a phase 1 trial

Cassandra AldrichIsabel Leroux-RoelsKatell Bidet HuangMihai Alexandru BicaEdde LoeligerOliver Schoenborn-KellenbergerLisa WalzGeert Leroux-RoelsFrank von SonnenburgLidia Oostvogels

A1 Journal Article in VACCINE

Safety and immunogenicity of a new Sabin inactivated poliovirus vaccine candidate produced on the PER.C6 (R) cell-line : a phase 1 randomized controlled trial in adults

Isabel Leroux-RoelsGeert Leroux-RoelsGeorgi ShukarevHanneke SchuitemakerConor CahillRichard de RooijMartin StruijsHester van ZeeburgJeanne-Marie Jacquet

A1 Journal Article in HUMAN VACCINES & IMMUNOTHERAPEUTICS

Safety and immunogenicity of an mRNA-lipid nanoparticle vaccine candidate against SARS-CoV-2 : a phase 1 randomized clinical trial

PG KremsnerP MannA KroidlIsabel Leroux-RoelsC SchindlerJJ GaborM SchunkGeert Leroux-RoelsJJ BoschR Fendel et al.

A1 Journal Article in WIENER KLINISCHE WOCHENSCHRIFT

Safety and immunogenicity of two novel type 2 oral poliovirus vaccine candidates compared with a monovalent type 2 oral poliovirus vaccine in healthy adults : two clinical trials

Ilse De CosterIsabel Leroux-RoelsAnanda S. BandyopadhyayChristopher GastKanchanamala WithanageKatie SteenackersPhilippe De SmedtAnnelies AerssensGeert Leroux-RoelsM. Steven Oberste et al.

A1 Journal Article in LANCET

2020

Detection of H1 swine influenza a virus antibodies in human serum samples by age group

Elien VandoornIsabel Leroux-RoelsGeert Leroux-RoelsAnna ParysAmy VincentKristien Van Reeth

A1 Journal Article in EMERGING INFECTIOUS DISEASES

Persistence of vaccine-elicited immune response up to 14 years post-HIV gp120-NefTat/AS01(B) vaccination

Olivier Van Der MeerenErik JongertKelly E. SeatonMarguerite KoutsoukosAnnelies AerssensCaroline BrackettMuriel DeboisMichel JanssensGeert Leroux-RoelsDoris Mesia Vela et al.

A1 Journal Article in VACCINE

2018

Adjuvant-associated peripheral blood mRNA profiles and kinetics induced by the adjuvanted recombinant protein candidate tuberculosis vaccine M72/AS01 in Bacillus Calmette–Guérin-vaccinated adults

Robert A. van den BergLaurane De MotGeert Leroux-RoelsViviane BechtoldFrédéric ClementMargherita CocciaErik JongertThomas G. EvansPaul GillardRobbert G. van der Most

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Development and characterization of a human monoclonal antibody targeting the N-terminal region of hepatitis C virus envelope glycoprotein E1

Ahmed Atef Ahmed Abouzeid MesalamIsabelle DesombereAliasghar Farhoudi MoghadamFreya Van HoutteLieven VerhoyeJonathan BallJean DubuissonSteven KH FoungArvind H PatelMats AA Persson et al.

A1 Journal Article in VIROLOGY

Differences in antigenic sites and other functional regions between genotype A and G mumps virus surface proteins

Sigrid GoumaTessa VermeireSteven Van GuchtLennart MartensVeronik HutseJeroen CremerPaul A RotaGeert Leroux-RoelsMarion KoopmansRob van Binnendijk et al.

A1 Journal Article in SCIENTIFIC REPORTS

2017

A novel neutralizing human monoclonal antibody broadly abrogates hepatitis C virus infection in vitro and in vivo

Isabelle DesombereAhmed Atef Ahmed Abouzeid MesalamRichard A UrbanowiczFreya Van HoutteLieven VerhoyeZhen-Yong KeckAliasghar Farhoudi MoghadamKoen VercauterenKarin WeeningThomas F Baumert et al.

A1 Journal Article in ANTIVIRAL RESEARCH

Characterization of a novel monoclonal antibody targeting epitope II within hepatitis C virus E2 envelope glycoprotein

Philip MeulemanAhmed Atef Ahmed Abouzeid MesalamIsabelle DesombereRichard UrbanowiczFreya Van HoutteLieven VerhoyeZhen-Yong KeckAliasghar Farhoudi MoghadamKoen VercauterenKarin Weening et al.

Development and characterization of a human monoclonal antibody for prevention of HCV recurrence in liver transplant patients

Ahmed Atef Ahmed Abouzeid MesalamIsabelle DesombereRichard UrbanowiczDaniel X JohanssonKoen VercauterenAliasghar Farhoudi MoghadamFreya Van HoutteLieven VerhoyeMats PerssonJonathan Ball et al.

Different adjuvants induce common innate pathways that are associated with enhanced adaptive responses against a model antigen in humans

Wivine BurnyAndrea CallegaroViviane BechtoldFrédéric ClementSophie DelhayeLaurence FissetteMichel JanssensGeert Leroux-RoelsArnaud MarchantRobert A. van den Berg et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Effect of hepatitis E virus infection on the human hepatic innate immune response in human liver chimeric mice

Ibrahim Mahmoud Sayed IbrahimLieven VerhoyeLaurance CocquerelFlorence AbravanelLander FoquetClaire MontpellierYannick DebingAliasghar Farhoudi MoghadamCzeslaw WychowskiJean Dubuisson et al.

Impact of HEV infection on the human hepatic innate immune response in human liver chimeric mice

Ibrahim Mahmoud Sayed IbrahimLieven VerhoyeLander FoquetFlorence AbravanelAliasghar Farhoudi MoghadamGeert Leroux-RoelsJacques IzopetPhilip Meuleman

Long-term persistence of cell-mediated and humoral responses to A(H1N1)pdm09 influenza virus vaccines and the role of the AS03 adjuvant system in adults during two randomized controlled trials

Robbert G. van der MostFrédéric ClementJulie WillekensWalthère DewéKarl WalravensDavid W. VaughnGeert Leroux-Roels

A1 Journal Article in CLINICAL AND VACCINE IMMUNOLOGY

Study of hepatitis E virus infection of genotype 1 and 3 in mice with humanised liver

Ibrahim Mahmoud Sayed IbrahimLieven VerhoyeLaurence CocquerelFlorence AbravanelLander FoquetClaire MontpellierYannick DebingAliasghar Farhoudi MoghadamCzeslaw WychowskiJean Dubuisson et al.

A1 Journal Article in GUT

Successful engraftment of human hepatocytes in uPA-SCID and FRG® KO mice

Lander FoquetElizabeth M WilsonLieven VerhoyeMarkus GrompeGeert Leroux-RoelsJohn BialPhilip Meuleman

Bookchapter in Hepatocyte transplantation : methods and protocols

Transmission of hepatitis E virus infection to human-liver chimeric FRG mice using patient plasma

Ibrahim Mahmoud Sayed IbrahimLander FoquetLieven VerhoyeAliasghar Farhoudi MoghadamFloresence AbravanelGeert Leroux-RoelsJacques IzopetPhilip Meuleman

A1 Journal Article in ANTIVIRAL RESEARCH

2016

A monoclonal antibody-based immunoassay to measure the antibody response against the repeat region of the circumsporozoite protein of Plasmodium falciparum

Kristina RadinFrédéric ClementErik JongertYann G-J SterckxChristian OckenhouseJason RegulesFranck LemialeGeert Leroux-Roels

A monoclonal antibody-based immunoassay to measure the antibody response against the repeat region of the circumsporozoite protein of Plasmodium falciparum

Kristina RadinFrédéric ClementErik JongertYann GJ SterckxChristian OckenhouseJason RegulesFranck LemialeGeert Leroux-Roels

A1 Journal Article in MALARIA JOURNAL

A randomized, observer-blind phase Ib study to identify formulations and vaccine schedules of a trivalent Group B Streptococcus vaccine for use in non-pregnant and pregnant women

Geert Leroux-RoelsCathy MaesJulie WillekensFIEN DE BOEVERRichard de RooijLeah MartellLisa BedellFrederick WittkeKaren SlobodPeter Dull

A1 Journal Article in VACCINE

Antibody persistence and booster responses to split-virion H5N1 avian influenza vaccine in young and elderly adults

Rajeka LazarusSarah KellyMatthew D SnapeCorinne VandermeulenMerryn VoyseyKarel HoppenbrouwersAnnick HensPierre Van DammeStephanie PepinIsabel Leroux-Roels et al.

A1 Journal Article in PLOS ONE

Characterization of a novel human monoclonal antibody targeting the hepatitis C virus envelope protein

Ahmed Atef Ahmed Abouzeid MesalamIsabelle DesombereRichard UrbanowiczDaniel X JohanssonKoen VercauterenAliasghar Farhoudi MoghadamFreya Van HoutteLieven VerhoyeMats PerssonJonathan Ball et al.

Effect of hepatitis E virus infection on the human hepatic innate immune response in human liver chimeric mice

Ibrahim Mahmoud Sayed IbrahimLieven VerhoyeLaurance CocquerelFlorence AbravanelLander FoquetClaire MontpellierYannick DebingAliasghar Farhoudi MoghadamCzeslaw WychowskiJean Dubuisson et al.

Immunogenicity and safety of a novel monovalent high-dose inactivated poliovirus type 2 vaccine in infants : a comparative, observer-blind, randomised, controlled trial

Xavier Saez-LlorensRalf ClemensGeert Leroux-RoelsJose JimenoSue Ann Costa ClemensWilliam C WeldonM Steven ObersteNatanael MolinaAnanda S Bandyopadhyay

A1 Journal Article in LANCET INFECTIOUS DISEASES

Immunogenicity of AS03-adjuvanted and non-adjuvanted trivalent inactivated influenza vaccines in elderly adults : a phase 3, randomized trial and post-hoc correlate of protection analysis

Guillermo M Ruiz-PalaciosGeert Leroux-RoelsJiri BeranJeanne-Marie DevasterMeral EsenOdile LaunayJanet E McElhaneyGerrit A van EssenAnne BenoitCarine Claeys et al.

A1 Journal Article in HUMAN VACCINES & IMMUNOTHERAPEUTICS

Impact of adjuvants on CD4+ T cell and B cell responses to a protein antigen vaccine : results from a phase II, randomized, multicenter trial

Geert Leroux-RoelsArnaud MarchantJack LevyPierre Van DammeTino F SchwarzYves HorsmansWolfgang JilgPeter G KremsnerEdwige HaeltermanFrédéric Clement et al.

A1 Journal Article in CLINICAL IMMUNOLOGY

In vitro and in vivo metabolism studies of dimethazine

Lore GeldofEva Tudela PalomarLeen LootensJasper Van LysebethPhilip MeulemanGeert Leroux-RoelsPeter Van EenooKoen Deventer

A1 Journal Article in BIOMEDICAL CHROMATOGRAPHY

Metabolic studies of prostanozol with the uPA-SCID chimeric mouse model and human liver microsomes

Lore GeldofLeen LootensLieselot DecroixPhilip MeulemanFrancesco BotrèGeert Leroux-RoelsKoen DeventerPeter Van Eenoo

A1 Journal Article in STEROIDS

Monoclonal anti-envelope antibody AP33 protects humanized mice against a patient-derived hepatitis C virus challenge

Isabelle DesombereSamira Fafi-KremerFreya Van HouttePatrick PessauxAliasghar Farhoudi MoghadamLaura HeydmannLieven VerhoyeSarah ColeJane A McKeatingGeert Leroux-Roels et al.

A1 Journal Article in HEPATOLOGY

Neutropenia as an adverse event following vaccination : results from randomized clinical trials in healthy adults and systematic review

Vincent Muturi-KioiDavid LewisOdile LaunayGeert Leroux-RoelsAlessandra AnemonaPierre LoulergueCaroline L BodinhamAnnelies AerssensNicola GrothAllan Saul et al.

A1 Journal Article in PLOS ONE

Phase I, randomized, observer-blind, placebo-controlled studies to evaluate the safety, reactogenicity and immunogenicity of an investigational non-typeable Haemophilus influenzae (NTHi) protein vaccine in adults

Geert Leroux-RoelsPierre Van DammeWouter HaazenSepehr ShakibMagalie CaubetEmmanuel ArisJeanne-Marie DevasterMathieu Peeters

A1 Journal Article in VACCINE

Targeting a host-cell entry factor barricades antiviral-resistant HCV variants from on-therapy breakthrough in human-liver mice

Koen VercauterenRichard JP BrownAhmed Atef Ahmed Abouzeid MesalamJuliane DoerrbeckerSabin BhujuRobert GeffersNaomi Van den EedeC Patrick McClureFulvia TroiseLieven Verhoye et al.

A1 Journal Article in GUT

2015

A broadly neutralizing monoclonal antibody targeting hepatitis C virus prevents viral infection in vitro and in uPA/SCID mice with humanized liver

Ahmed Atef Ahmed Abouzeid MesalamIsabelle DesombereRichard UrbanowiczDaniel X JohanssonAliasghar Farhoudi MoghadamFreya Van HoutteLieven VerhoyeMats PerssonJonathan BallGeert Leroux-Roels et al.

A broadly neutralizing monoclonal antibody targeting hepatitis C virus prevents viral infection in vitro and in uPA/SCID mice with humanized liver

Ahmed Atef Ahmed Abouzeid MesalamIsabelle DesombereRichard UrbanowiczDaniel X JohanssonKoen VercauterenAliasghar Farhoudi MoghadamFreya Van HoutteLieven VerhoyeKarin WeeningMats Persson et al.

A broadly neutralizing monoclonal antibody targeting hepatitis C virus prevents viral infection in vitro and in uPA/SCID mice with humanized liver

Ahmed Atef Ahmed Abouzeid MesalamIsabelle DesombereRichard UrbanowiczDaniel X JohanssonAliasghar Farhoudi MoghadamFreya Van HoutteLieven VerhoyeMats PerssonJonathan BallGeert Leroux-Roels et al.

A humanized mouse model for the study of infection with Plasmodium falciparum : development and applications

Lander FoquetGeert Leroux-RoelsPhilip Meuleman

Adjuvant system AS02V enhances humoral and cellular immune responses to pneumococcal protein PhtD vaccine in healthy young and older adults: randomised, controlled trials

Isabel Leroux-RoelsJeanne-Marie DevasterGeert Leroux-RoelsVincent VerlantIsabelle HenckaertsPhilippe MorisPhilippe HermandPascale Van BelleJan T PoolmanPierre Vandepapeliére et al.

A1 Journal Article in VACCINE

Anti-CD81 but not anti-SR-BI blocks Plasmodium falciparum liver infection in a humanized mouse model

Lander FoquetCornelus C HermsenLieven VerhoyeGeert-Jan van GemertRiccardo CorteseAlfredo NicosiaRobert W SauerweinGeert Leroux-RoelsPhilip Meuleman

A1 Journal Article in JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Assessment of parasite liver-stage burden in human-liver chimeric mice

Lander FoquetPhilip MeulemanCornelus C HermsenRobert SauerweinGeert Leroux-Roels

Bookchapter in Malaria vaccines

Generation and characterization of small single domain antibodies inhibiting human tumor necrosis factor receptor 1

Sophie SteelandLeen PuimègeRoosmarijn VandenbrouckeFilip Van HauwermeirenJurgen HaustraeteNick DevoogdtPaco HulpiauGeert Leroux-RoelsDebby LaukensPhilip Meuleman et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Hemagglutination inhibition antibody titers as a correlate of protection against seasonal A/H3N2 influenza disease

Anne BenoitJiri BeranJeanne-Marie DevasterMeral EsenOdile LaunayGeert Leroux-RoelsJanet E McElhaneyLidia OostvogelsGerrit A van EssenManjusha Gaglani et al.

A1 Journal Article in OPEN FORUM INFECTIOUS DISEASES

Human liver chimeric mice as a novel model for the study of hepatitis E virus infections

Ibrahim Mahmoud Sayed IbrahimLieven VerhoyeAliasghar Farhoudi MoghadamYannick DebingJohan NeytsGeert Leroux-RoelsRobert PurcellSuzanne EmersonPhilip Meuleman

Human liver chimeric mice as a novel model for the study of hepatitis E virus infections

Ibrahim Mahmoud Sayed IbrahimLieven VerhoyeLaurence CocquerelFlorence AbbravanelLander FoquetYannick DebingAliasghar Farhoudi MoghadamCzeslaw WychowskiJean DubuissonGeert Leroux-Roels et al.

Human liver chimeric mice as a novel model for the study of hepatitis E virus infections

Ibrahim Mahmoud Sayed IbrahimLieven VerhoyeY DebingF AbbravanelAliasghar Farhoudi MoghadamGeert Leroux-RoelsJ NeytsJ IzopetR PurcellS Emerson et al.

Old and new adjuvants for hepatitis B vaccines

Geert Leroux-Roels

A1 Journal Article in MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Response to publications by Heyward W et al. and Kuan R et al.: clinical and cost-effectiveness analyses, respectively, of hepatitis B vaccination-Heplisav™ compared with Engerix-B® vaccine in adults

Marc De RidderDesmond CurranGeert Leroux-Roels

A1 Journal Article in VACCINE

Safety and immunogenicity of an MF59®-adjuvanted A/H1N1 pandemic influenza vaccine in children from three to seventeen years of age

Markus KnufGeert Leroux-RoelsHans. C RamkeKatia AbarcaLuis RiveraMaria LattanziPaola PedottiAshwani AroraDorothee Kieninger-BaumGiovanni Della Cioppa

A1 Journal Article in VACCINE

Targeting a host-cell entry factor barricades antiviral-resistant HCV variants from on-therapy breakthrough in human-liver mice

Koen VercauterenRichard JP BrownAhmed Atef Ahmed Abouzeid MesalamJuliane DoerrbeckerSabin BhujuRobert GeffersNaomi Van den EedeFulvia TroiseLieven VerhoyeThomas Baumert et al.

Vaccine Adjuvant Systems containing monophosphoryl lipid A and QS-21 induce strong humoral and cellular immune responses against hepatitis B surface antigen which persist for at least 4 years after vaccination

Geert Leroux-RoelsPascale Van BellePierre VandepapeliereYves HorsmansMichel JanssensIsabelle CarlettiNathalie GarçonMartine WettendorffMarcelle Van Mechelen

A1 Journal Article in VACCINE

2014

A dose-ranging study in older adults to compare the safety and immunogenicity profiles of MF59®-adjuvanted and non-adjuvanted seasonal influenza vaccines following intradermal and intramuscular administration

Giovanni Della CioppaUwe NicolayKelly LindertGeert Leroux-RoelsFrédéric ClementFlora CastellinoGrazia GalliNicola GrothYotam LevinGiuseppe Del Giudice

A1 Journal Article in HUMAN VACCINES & IMMUNOTHERAPEUTICS

A genetically attenuated malaria vaccine candidate based on P. falciparum b9/slarp gene-deficient sporozoites

Ben CL van SchaijkIvo HJ PloemenTakeshi AnnouraMartijn W VosLander FoquetGeert-Jan van GemertSeverine Chevalley-MaurelMarga van de Vegte-BolmerMohammed SajidJean-Francois Franetich et al.

A1 Journal Article in eLIFE

Avidity of anti-circumsporozoite antibodies following vaccination with RTS,S/AS01(E) in young children

Ally OlotuFrédéric ClementErik JongertJohan VekemansPatricia NjugunaFrancis M NdunguKevin MarshGeert Leroux-RoelsPhilip Bejon

A1 Journal Article in PLOS ONE

Clinicopathological, immunohistochemical and molecular characterization of lipomatous tumors: new pathogenic insights and diagnostic tools

David CreytensGeert Leroux-RoelsJohan Vande WalleJoost van Gorp

Combined adenovirus vector and hepatitis C virus envelope protein prime-boost regimen elicits T cell and neutralizing antibody immune responses

Alicja M ChmielewskaMariarosaria NaddeoStefania CaponeVirginia AmmendolaKe HuLuke MeredithLieven VerhoyeMalgorzata RychlowskaRino RappuoliJeffrey B Ulmer et al.

A1 Journal Article in JOURNAL OF VIROLOGY

Effects of varying antigens and adjuvant systems on the immunogenicity and safety of investigational tetravalent human oncogenic papillomavirus vaccines: results from two randomized trials

Pierre Van DammeGeert Leroux-RoelsPhilippe SimonJean-Michel FoidartGilbert DondersKarel HoppenbrouwersMyron LevinFabian TibaldiSylviane PonceletPhilippe Moris et al.

A1 Journal Article in VACCINE

Evaluation of the immune response to RTS,S/AS01 and RTS,S/AS02 adjuvanted vaccines : randomized, double-blind study in malaria-naïve adults

Geert Leroux-RoelsIsabel Leroux-RoelsFrédéric ClementOpokua Ofori-AnyinamMarc LievensErik JongertPhilippe MorisW Ripley BallouJoe Cohen

A1 Journal Article in HUMAN VACCINES & IMMUNOTHERAPEUTICS

Genetic and antigenic typing of seasonal influenza virus breakthrough cases from a 2008-2009 vaccine efficacy trial

Serge DurviauxJohn TreanorJiri BeranXavier DuvalMeral EsenGregory FeldmanSharon E FreyOdile LaunayGeert Leroux-RoelsJanet E McElhaney et al.

A1 Journal Article in CLINICAL AND VACCINE IMMUNOLOGY

Human liver chimeric mice as a novel model for the study of hepatitis E virus infections

Ibrahim Mahmoud Sayed IbrahimLieven VerhoyeAliasghar Farhoudi MoghadamYannick DebingJohan NeytsGeert Leroux-RoelsRobert PurcellSuzanne EmersonPhilip Meuleman

Human skin-derived precursor cells are poorly immunogenic and modulate the allogeneic immune response

Joery De KockPhilip MeulemanGordana RaicevicRobim M RodriguesSteven BransonKesavan MeganathanVeerle De BoeAgapios SachinidisGeert Leroux-RoelsTamara Vanhaecke et al.

A1 Journal Article in STEM CELLS

Immunogenicity and safety of a booster dose of an investigational adjuvanted polyprotein HIV-1 vaccine in healthy adults and effect of administration of chloroquine

Geert Leroux-RoelsPatricia BourguignonJulie WillekensMichel JanssensFrédéric ClementArnaud M DidierlaurentLaurence FissetteFrançois RomanDominique Boutriau

A1 Journal Article in CLINICAL AND VACCINE IMMUNOLOGY

Immunogenicity and tolerability of an MF59-adjuvanted, egg-derived, A/H1N1 pandemic influenza vaccine in children 6-35 months of age

Markus KnufGeert Leroux-RoelsHans C RümkeKatia AbarcaLuis RiveraMaria LattanziPaola PedottiAshwani AroraDorothee Kieninger-BaumGiovanni Della Cioppa

A1 Journal Article in PEDIATRIC INFECTIOUS DISEASE JOURNAL

Impact of lipids and lipoproteins on hepatitis C virus infection and virus neutralization

Koen VercauterenAhmed Atef Ahmed Abouzeid MesalamGeert Leroux-RoelsPhilip Meuleman

A1 Journal Article in WORLD JOURNAL OF GASTROENTEROLOGY

Influenza symptoms and their impact on elderly adults : randomised trial of AS03-adjuvanted or non-adjuvanted inactivated trivalent seasonal influenza vaccines

Gerrit A van EssenJiri BeranJeanne-Marie DevasterChristelle DurandXavier DuvalMeral EsenAnn R FalseyGregory FeldmanPierre GervaisBruce L Innis et al.

A1 Journal Article in INFLUENZA AND OTHER RESPIRATORY VIRUSES

Metabolic study of a steroid product containing dimethazine using human liver microsomes and a chimeric mouse model

Lore GeldofEva TudelaLeen LootensJasper Van LysebethPhilip MeulemanGeert Leroux-RoelsKoen DeventerPeter Van Eenoo

Metabolism of methylstenbolone studied with human liver microsomes and the uPA+/+-SCID chimeric mouse model

Lore GeldofLeen LootensMichaël PoletDaniel EichnerThane CampbellVinod NairFrancesco BotrèPhilip MeulemanGeert Leroux-RoelsKoen Deventer et al.

A1 Journal Article in BIOMEDICAL CHROMATOGRAPHY

Processing of blood samples influences PBMC viability and outcome of cell-mediated immune responses in antiretroviral therapy-naïve HIV-1-infected patients

Patricia BourguignonFrédéric ClementFrédéric RenaudVivien Le BrasMarguerite KoutsoukosWivine BurnyPhilippe MorisClarisse LorinAlix CollardGeert Leroux-Roels et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGICAL METHODS

Respiratory syncytial virus and other respiratory viral infections in older adults with moderate to severe influenza-like illness

Ann R FalseyJanet E McElhaneyJiri BeranGerrit A van EssenXavier DuvalMeral EsenFlorence GaltierPierre GervaisShinn-Jang HwangPeter Kremsner et al.

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

Safety, reactogenicity and immunogenicity of a novel pneumococcal protein-based vaccine in adults : a phase I/II randomized clinical study

Geert Leroux-RoelsCathy MaesFIEN DE BOEVERMagali TraskineJens U RüggebergDorota Borys

A1 Journal Article in VACCINE

Sporozoite immunization of human volunteers under chemoprophylaxis induces functional antibodies against pre-erythrocytic stages of Plasmodium falciparum

Marije C BehetLander FoquetGeert-Jan van GemertElse M BijkerPhilip MeulemanGeert Leroux-RoelsCornelus C HermsenAnja ScholzenRobert W Sauerwein

A1 Journal Article in MALARIA JOURNAL

Successful anti-scavenger receptor class B type I (SR-BI) monoclonal antibody therapy in humanized mice after challenge with HCV variants with in vitro resistance to SR-BI-targeting agents

Koen VercauterenNaomi Van den EedeAhmed Atef Ahmed Abouzeid MesalamSandrine BelouzardMaria Teresa CataneseDorothea BankwitzFlossie Wong-StaalRiccardo CorteseJean DubuissonCharles M Rice et al.

A1 Journal Article in HEPATOLOGY

Targeting SR-BI for the prevention and treatment of hepatitis C virus infections

Koen VercauterenPhilip MeulemanGeert Leroux-Roels

The human immune response to HIV-1 : its role in disease progression and vaccine development

Eva Van BraeckelGeert Leroux-Roels

Vaccine-induced monoclonal antibodies targeting circumsporozoite protein prevent Plasmodium falciparum infection

Lander FoquetCornelus C HermsenGeert-Jan van GemertEva Van BraeckelKarin WeeningRobert SauerweinPhilip MeulemanGeert Leroux-Roels

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

2013

AS03-adjuvanted versus non-adjuvanted inactivated trivalent influenza vaccine against seasonal influenza in elderly people: a phase 3 randomised trial

Janet E McElhaneyJiri BeranJeanne-Marie DevasterMeral EsenOdile LaunayGeert Leroux-RoelsGuillermo M Ruiz-PalaciosGerrit A van EssenAdrian CaplanusitCarine Claeyst et al.

A1 Journal Article in LANCET INFECTIOUS DISEASES

Clinical evaluation to confirm the manufacturing consistency of three lots of an adjuvanted glycoprotein D genital herpes vaccine in healthy seronegative pre-teen and adolescent girls: a phase III multi-center double-blind randomized trial

Geert Leroux-RoelsSimon DobsonDavid I BernsteinSandra FowlerBarbara RomanowskiIsabel Leroux-RoelsBrigitte CheuvartThomas HeinemanGary Dubin

A2 Journal Article in TRIALS IN VACCINOLOGY

Immunogenicity and safety of different formulations of an adjuvanted glycoprotein D genital herpes vaccine in healthy adults: a double-blind randomized trial

Geert Leroux-RoelsFrédéric ClementPierre VandepapeliereMarc FourneauThomas HeinemanGary Dubin

A1 Journal Article in HUMAN VACCINES & IMMUNOTHERAPEUTICS

Improved CD4⁺ T cell responses to Mycobacterium tuberculosis in PPD-negative adults by M72/AS01 as compared to the M72/AS02 and Mtb72F/AS02 tuberculosis candidate vaccine formulations: a randomized trial

Isabel Leroux-RoelsSheron ForgusFIEN DE BOEVERFrédéric ClementMarie-Ange DemoitiéPascal MettensPhilippe MorisEdouard LedentGeert Leroux-RoelsOpokua Ofori-Anyinam

A1 Journal Article in VACCINE

In vitro and in vivo metabolism studies of a nutritional supplement containing methylstenbolone

Lore GeldofLeen LootensKoen DeventerMichaël PoletDaniel EichnerFrancesco BotrèPhilip MeulemanGeert Leroux-RoelsPeter Van Eenoo

In vitro and in vivo metabolisms of 1-pentyl-3-(4-methyl-1-naphthoyl)indole (JWH-122)

Nik De BrabanterSimone EspositoLore GeldofLeen LootensPhilip MeulemanGeert Leroux-RoelsKoen DeventerPeter Van Eenoo

A1 Journal Article in FORENSIC TOXICOLOGY

In vivo and in vitro metabolism of the synthetic cannabinoid JWH-200

Nik De BrabanterSimone EspositoEva Tudela PalomarLeen LootensPhilip MeulemanGeert Leroux-RoelsKoen DeventerPeter Van Eenoo

A1 Journal Article in RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Molecular detection and quantification of Plasmodium falciparum-infected human hepatocytes in chimeric immune-deficient mice

Lander FoquetCornelus C HermsenGeert-Jan van GemertLouis LibbrechtRobert SauerweinPhilip MeulemanGeert Leroux-Roels

A1 Journal Article in MALARIA JOURNAL

Polyfunctional CD4⁺ T cell responses in HIV-1 infected viral controllers compared with those in healthy recipients of an adjuvanted polyprotein HIV-1 vaccine

Eva Van BraeckelIsabelle DesombereFrédéric ClementLinos VandekerckhoveChris VerhofstedeDirk VogelaersGeert Leroux-Roels

A1 Journal Article in VACCINE

Randomized phase I : safety, immunogenicity and mucosal antiviral activity in young healthy women vaccinated with HIV-1 Gp41 P1 peptide on virosomes

Geert Leroux-RoelsCathy MaesFrédéric ClementFrank Van EngelenburgMarieke van den DobbelsteenMichael AdlerMario AmackerLucia LopalcoMorgane BomselAnick Chalifour et al.

A1 Journal Article in PLOS ONE

Safety and immunogenicity of a glycoprotein D genital herpes vaccine in healthy girls 10-17 years of age: results from a randomised, controlled, double-blind trial

The HSV-040 Study groupJH RichardusRR Abu-ElyazeedT HeinemanG DubinM FourneauIsabel Leroux-RoelsGeert Leroux-RoelsL OstergaardJ Diez-Domingo et al.

A1 Journal Article in VACCINE

2012

A human monoclonal antibody targeting scavenger receptor class B type I precludes hepatitis C virus infection and viral spread in vitro and in vivo

Philip MeulemanMaria Teresa CataneseLieven VerhoyeIsabelle DesombereAliasghar Farhoudi MoghadamChristopher T JonesTimothy SheahanKatarzyna GrzybRiccardo CorteseCharles M Rice et al.

A1 Journal Article in HEPATOLOGY

A phase 1/2 clinical trial evaluating safety and immunogenicity of a varicella zoster glycoprotein E subunit vaccine candidate in young and older adults

Isabel Leroux-RoelsGeert Leroux-RoelsFrédéric ClementPierre VandepapelièreVentzislav VassilevEdouard LedentThomas C Heineman

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

A randomised, single-blind, dose-range study to assess the immunogenicity and safety of a cell-culture-derived A/H1N1 influenza vaccine in adult and elderly populations

Christoph HatzJakob P CramerAndré VertruyenTino F SchwarzFrank von SonnenburgAstrid BorkowskiMaria LattanziAnne Katrin HilbertGiovanni Della CioppaGeert Leroux-Roels

A1 Journal Article in VACCINE

A randomized clinical trial to identify the optimal antigen and MF59® adjuvant dose of a monovalent A/H1N1 pandemic influenza vaccine in healthy adult and elderly subjects

Christoph HatzFrank von SonnenburgDaniela CasulaMaria LattanziGeert Leroux-Roels

A1 Journal Article in VACCINE

Antibody persistence and immune memory in adults, 15 years after a three-dose schedule of a combined hepatitis A and B vaccine

Pierre Van DammeGeert Leroux-RoelsP CrastaM MessierJeanne-Marie JacquetKoen Van Herck

A1 Journal Article in JOURNAL OF MEDICAL VIROLOGY

Blocking HCV entry as potential antiviral therapy

Koen VercauterenGeert Leroux-RoelsPhilip Meuleman

A1 Journal Article in FUTURE VIROLOGY

HIV vaccines: can CD4⁺ T cells be of help?

Eva Van BraeckelGeert Leroux-Roels

Editorial material

Influenza vaccines: T-cell responses deserve more attention

Michael SchotsaertXavier SaelensGeert Leroux-Roels

A1 Journal Article in EXPERT REVIEW OF VACCINES

Metabolic study of prostanozol using human liver licrosomes and humanized mice

Leen LootensLore GeldofLieselot DecroixKoen DeventerFrancesco BotrèGeert Leroux-RoelsPhilip MeulemanPeter Van Eenoo

Mitochondrial cardiotoxicity of a prototype HCV NS3-protease inhibitor is characterized by a specific electrocardiographic signature in mice

Thomas VanwolleghemEva Van BraeckelJoél SmetBi-Sheng LiuPhilip MeulemanHarry L JanssenTania RoskamsRudy Van CosterRita De VosGeert Leroux-Roels

Novel human SR-BI antibodies prevent infection and dissemination of HCV in vitro and in humanized mice

Krzysztof LacekKoen VercauterenKatarzyna GrzybMariarosaria NaddeoLieven VerhoyeMarek Patryk SłowikowskiSamira Fafi-KremerArvind H PatelThomas F BaumertAntonella Folgori et al.

A1 Journal Article in JOURNAL OF HEPATOLOGY

Persistence and immune memory to hepatitis B vaccine 20 y after primary vaccination of Thai infants, born to HBsAg and HBeAg positive mothers

Yong PoovorawanVoranush ChongsrisawatApiradee TheamboonlersGeert Leroux-RoelsPriya Diana CrastaKarin Hardt

A1 Journal Article in HUMAN VACCINES & IMMUNOTHERAPEUTICS

Superior immunogenicity of seasonal influenza vaccines containing full dose of MF59® adjuvant: results from a dose-finding clinical trial in older adults

Giovanni Della CioppaUwe NicolayKelly LindertGeert Leroux-RoelsFrédéric ClementFlora CastellinoGrazia GalliNicola GrothGiuseppe Del Giudice

A1 Journal Article in HUMAN VACCINES & IMMUNOTHERAPEUTICS

The Sin3a repressor complex is a master regulator of STAT transcriptional activity

Laura IcardiRaffaele MoriViola GesellchenSven EyckermanLode De CauwerJudith VerhelstKoen VercauterenXavier SaelensPhilip MeulemanGeert Leroux-Roels et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Validation of an enzyme-linked immunosorbent assay for the quantification of human IgG directed against the repeat region of the circumsporozoite protein of the parasite Plasmodium falciparum.

Frédéric ClementVincent DewarEva Van BraeckelIsabelle DesombereMarianne DewerchinChristine SwysenMarie-Ange DemoitiéErik JongertJoe CohenGeert Leroux-Roels et al.

A1 Journal Article in MALARIA JOURNAL

2011

An adjuvanted polyprotein HIV-1 vaccine induces polyfunctional cross-reactive CD4+ T cell responses in seronegative volunteers

Eva Van BraeckelPatricia BourguignonMarguerite KoutsoukosFrédéric ClementMichel JanssensIsabelle CarlettiAlix CollardMarie-Ange DemoitiéGerald VossGeert Leroux-Roels et al.

A1 Journal Article in CLINICAL INFECTIOUS DISEASES

Development and application of hepatitis C reporter viruses with genotype 1 to 7 core-nonstructural protein 2 (NS2) expressing fluorescent proteins or luciferase in modified JFH1 NS5A

Judith M GottweinTanja B JensenChristian K MathiesenPhilip MeulemanStephanie BN SerreJacob B LademannLubna GhanemTroels KH ScheelGeert Leroux-RoelsJens Bukh

A1 Journal Article in JOURNAL OF VIROLOGY

Discovery of (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase

Frank NarjesBenedetta CrescenziMarco FerraraJörg HabermannStefania ColarussoMaria del Rosario FerreiraIan StansfieldAngela Claire MackayImmacolata ConteCaterina Ercolani et al.

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Effect on cellular and humoral immune responses of the AS03 adjuvant system in an A/H1N1/2009 influenza virus Vaccine administered to adults during two randomized controlled trials

François RomanFrédéric ClementWalthère DewéKarl WalravensCathy MaesJulie WillekensFIEN DE BOEVEREmmanuel HanonGeert Leroux-Roels

A1 Journal Article in CLINICAL AND VACCINE IMMUNOLOGY

Evidence of protection against clinical and chronic hepatitis B infection 20 years after infant vaccination in a high endemicity region

Y PoovorawanV ChongsrisawatA TheamboonlersGeert Leroux-RoelsS KuriyakoseM LeyssenJM Jacquet

A1 Journal Article in JOURNAL OF VIRAL HEPATITIS

Griffithsin has antiviral activity against hepatitis C virus

Philip MeulemanAnna AlbeckaSandrine BelouzardKoen VercauterenLieven VerhoyeCzeslaw WychowskiGeert Leroux-RoelsKenneth E PalmerJean Dubuisson

A1 Journal Article in ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

H5N1 influenza vaccine formulated with AS03A induces strong cross-reactive and polyfunctional CD4 T-cell responses

Philippe MorisRobbert van der MostIsabel Leroux-RoelsFrédéric ClementMamadou DraméEmmanuel HanonGeert Leroux-RoelsMarcelle Van Mechelen

A1 Journal Article in JOURNAL OF CLINICAL IMMUNOLOGY

Head-to-head comparison of pandemic influenza vaccines

Geert Leroux-RoelsIsabel Leroux-Roels

Editorial material

Hepatitis B vaccine effectiveness in the face of global HBV genotype diversity

Adrian CassidySally MossmanAntonio OlivieriMarc De RidderGeert Leroux-Roels

A1 Journal Article in EXPERT REVIEW OF VACCINES

Hypervariable region 1 differentially impacts viability of hepatitis C virus strains of genotypes 1 to 6 and impairs virus neutralization

Jannick PrentoeTanja B JensenPhilip MeulemanStephanie BN SerreTroels KH ScheelGeert Leroux-RoelsJudith M GottweinJens Bukh

A1 Journal Article in JOURNAL OF VIROLOGY

In vivo evaluation of the cross-genotype neutralizing activity of polyclonal antibodies against hepatitis C virus

Philip MeulemanJens BukhLieven VerhoyeAliasghar Farhoudi MoghadamThomas VanwolleghemRichard Y WangIsabelle DesombereHarvey AlterRobert H PurcellGeert Leroux-Roels

A1 Journal Article in HEPATOLOGY

Lipoprotein lipase inhibits hepatitis C virus (HCV) infection by blocking virus cell entry

Patrick MaillardMarine WalicPhilip MeulemanFarzin RoohvandThierry HubyWilfried Le GoffGeert Leroux-RoelsEve-Isabelle PécheurAgata Budkowska

A1 Journal Article in PLOS ONE

Metabolic studies with promagnon, methylclostebol and methasterone in the uPA+/+-SCID chimeric mice

Leen LootensPhilip MeulemanGeert Leroux-RoelsPeter Van Eenoo

A1 Journal Article in JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Mibolerone metabolism in the uPA+/+-SCID chimeric mice

Leen LootensAnnelies De SpaeyKoen DeventerP MeulemansGeert Leroux-RoelsPeter Van Eenoo

Randomized trial of the immunogenicity and safety of the hepatitis B vaccine given in an accelerated schedule coadministered with the human papillomavirus type 16/18AS04-adjuvanted cervical cancer vaccine

Geert Leroux-RoelsEdwige HaeltermanCathy MaesJack LevyFIEN DE BOEVERLaurent LiciniMarie-Pierre DavidKurt DobbelaereDominique Descamps

A1 Journal Article in CLINICAL AND VACCINE IMMUNOLOGY

Vaccine-induced HIV seropositivity: a problem on the rise

Eva Van BraeckelMarguerite KoutsoukosPatricia BourguignonFrédéric ClementLisa McNallyGeert Leroux-Roels

A1 Journal Article in JOURNAL OF CLINICAL VIROLOGY

2010

An adjuvanted protein HIV vaccine induces polyfunctional CD4 T-cell responses in healthy volunteers similar to those in HIV-infected viral controllers

Eva Van BraeckelFrédéric ClementLinos VandekerckhoveDirk VogelaersGeert Leroux-Roels

An adjuvanted protein HIV vaccine induces polyfunctional CD4(+) T-cell responses in healthy volunteers similar to those in HIV-infected viral controllers

Eva Van BraeckelFrédéric ClementLinos VandekerckhoveDirk VogelaersGeert Leroux-Roels

Application of in vivo urinary steroid detection in uPA+/+-SCID chimeric mice

Leen LootensPeter Van EenooPozo Mendoza Pozo MendozaP MeulemansGeert Leroux-RoelsFrans Delbeke

Baseline anti-NS4a antibodies in combination with on-treatment quantitative HCV-RNA reliably identifies nonresponders to pegylated interferon-ribavirin combination therapy after 4 weeks of treatment

Hans OrlentIsabelle DesombereBettina HansenHans Van VlierbergheBart HaagmansRobert J de KnegtSolko W SchalmGeert Leroux-RoelsHarry LA Janssen

A1 Journal Article in EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Challenge pools of hepatitis C virus genotypes 1-6 prototype strains: replication fitness and pathogenicity in chimpanzees and human liver-chimeric mouse models

Jens BukhPhilip MeulemanRaymond TellierRonald E EngleStephen M FeinstoneGerald EderWilliam C SatterfieldSugantha GovindarajanKrzysztof KrawczynskiRoger H Miller et al.

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

Combined Haemophilus influenzae type b and Neisseria meningitidis serogroup C (HibMenC) or serogroup C and Y-tetanus toxoid conjugate (and HibMenCY) vaccines are well-tolerated and immunogenic when administered according to the 2, 3, 4 months schedule with a fourth dose at 12-18 months of age

Pirmin HabermehlGeert Leroux-RoelsRoland SangerGudrun MachlerDominique Boutriau

A1 Journal Article in HUMAN VACCINES

Detection of mumps virus-specific memory B cells by transfer of peripheral blood mononuclear cells into immune-deficient mice

Corinne VandermeulenLieven VerhoyeSunil VaidyaFrédéric ClementKevin E BrownKarel HoppenbrouwersGeert Leroux-Roels

A1 Journal Article in IMMUNOLOGY

Evaluation of the safety and immunogenicity of two antigen concentrations of the Mtb72F/AS02A candidate tuberculosis vaccine in purified protein derivative-negative adults

Isabel Leroux-RoelsGeert Leroux-RoelsOpokua Ofori-AnyinamPhilippe MorisEls De KockFrédéric ClementMarie-Claude DuboisMarguerite KoutsoukosMarie-Ange DemoitieJoe Cohen et al.

A1 Journal Article in CLINICAL AND VACCINE IMMUNOLOGY

Factors determining successful engraftment of hepatocytes and susceptibility to hepatitis B and C virus infection in uPA-SCID mice

Thomas VanwolleghemLouis LibbrechtBettina E HansenIsabelle DesombereTania RoskamsPhilip MeulemanGeert Leroux-Roels

A1 Journal Article in JOURNAL OF HEPATOLOGY

HCV genotype distribution in Flanders and Brussels (Belgium): unravelling the spread of an uncommon HCV genotype 5a cluster

J VerbeeckL KwantenF D'HeygereA BeguinS MichielsIsabelle DesombereGeert Leroux-RoelsP LemeyF NevensM Van Ranst

A1 Journal Article in EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Priming with AS03A-adjuvanted H5N1 influenza vaccine improves the kinetics, magnitude and durability of the immune response after a heterologous booster vaccination: an open non-randomised extension of a double-blind randomised primary study

Isabel Leroux-RoelsFlorian RomanSheron ForgusCathy MaesFIEN DE BOEVERMamadou DramePaul GillardRobbert van der MostMarcelle Van MechelenEmmanuel Hanon et al.

A1 Journal Article in VACCINE

Production, characterization and in vitro testing of HBcAg-specific VHH intrabodies

Benedikte SerruysFreya Van HoutteAliasghar Farhoudi MoghadamGeert Leroux-RoelsPeter Vanlandschoot

A1 Journal Article in JOURNAL OF GENERAL VIROLOGY

Strong and persistent CD4+ T-cell response in healthy adults immunized with a candidate HIV-1 vaccine containing gp120, Nef and Tat antigens formulated in three Adjuvant Systems

Isabel Leroux-RoelsMarguerite KoutsoukosFrédéric ClementSophia SteyaertMichel JanssensPatricia BourguignonKristen CohenMarcus AltfeldPierre VandepapelièreLouise Pedneault et al.

A1 Journal Article in VACCINE

Unmet needs in modern vaccinology: adjuvants to improve the immune response

Geert Leroux-Roels

A1 Journal Article in VACCINE

Viral entry and escape from antibody-mediated neutralization influence hepatitis C virus reinfection in liver transplantation

Samira Fafi-KremerIsabel FofanaEric SoulierPatric CarollaPhilip MeulemanGeert Leroux-RoelsArvind H PatelFrançois-Loic CossetPatrick PessauxMichel Doffoel et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

2009

Combination of liquid-chromatography tandem mass spectrometry in different scan modes with human and chimeric mouse urine for the study of steroid metabolism

Pozo Mendoza Pozo MendozaLeen LootensPeter Van EenooKoen DeventerPhilip MeulemanGeert Leroux-RoelsMK ParrW SchanzerFrans Delbeke

A1 Journal Article in DRUG TESTING AND ANALYSIS

Current status and progress of prepandemic and pandemic influenza vaccine development

Isabel Leroux-RoelsGeert Leroux-Roels

A1 Journal Article in EXPERT REVIEW OF VACCINES

Detection and characterization of a new metabolite of 17 α-methyltestosterone

Pozo Mendoza Pozo MendozaPeter Van EenooKoen DeventerLeen LootensWim Van ThuyneMaria ParrWilhelm SchanzerJuan SanchoFelix HernandezPhilip Meuleman et al.

A1 Journal Article in DRUG METABOLISM AND DISPOSITION

Detection and structural investigation of metabolites of stanozolol in human urine by liquid chromatography tandem mass spectrometry

Pozo Mendoza Pozo MendozaPeter Van EenooKoen DeventerLeen LootensGrimalt SusanaJuan V SanchoFelix HernándezPhilip MeulemanGeert Leroux-RoelsFrans Delbeke

A1 Journal Article in STEROIDS

Endorsement of the Kidney Disease Improving Global Outcomes (KDIGO) hepatitis C guidelines: a European Renal Best Practice (ERBP) position statement

Adrian CovicDaniel AbramowiczAnnette BruchfeldGeert Leroux-RoelsDidier SamuelWim Van BiesenCarmine ZoccaliZoulim FabienRaymond Vanholder

A1 Journal Article in NEPHROLOGY DIALYSIS TRANSPLANTATION

Evaluation of cellular immunity to mumps in vaccinated individuals with or without circulating antibodies up to 16 years after their last vaccination

Corinne VandermeulenFrédéric ClementMathieu RoelantsPierre Van DammeKarel HoppenbrouwersGeert Leroux-Roels

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

HCV animal models : a journey of more than 30 years

Philip MeulemanGeert Leroux-Roels

A1 Journal Article in VIRUSES-BASEL

Humoral and cellular immune responses to split-virion H5N1 influenza vaccine in young and elderly adults

Isabel Leroux-RoelsMarie Van der WielenFroukje KafejaCorinne VandermeulenRajeka LazarusMatthew D SnapeTessa JohnChristophe CarreNolwenn NougaredeStephanie Pepin et al.

A1 Journal Article in VACCINE

Llama-Derived Single-Domain Intrabodies Inhibit Secretion of Hepatitis B Virions in Mice

Benedikte SerruysFreya Van HouttePhebe VerbruggheGeert Leroux-RoelsPeter Vanlandschoot

A1 Journal Article in HEPATOLOGY

Llama-derived single-domain intrabodies against the Hepatitis B Virus surface and core antigen

Benedikte SerruysGeert Leroux-RoelsPeter Vanlandschoot

Production of infectious genotype 1b virus particles in cell culture and impairment by replication enhancing mutations

T. PietschmannM. ZayasPhilip MeulemanG. LongN. AppelG. KoutsoudakisS. KallisGeert Leroux-RoelsV. LohmannR. Bartenschlager

A1 Journal Article in PLOS PATHOGENS

Reduced detection and levels of protective antibodies to hepatitis B vaccine in under 2-year-old HIV positive South African children at a paediatric outpatient clinic

Omphile E. SimaniGeert Leroux-RoelsGuido FrancoisRosemary J. BurnettAndre MeheusM. Jeffrey Mphahlele

A1 Journal Article in VACCINE

Steroid metabolism in chimeric mice with humanized liver

Leen LootensPeter Van EenooPhilip MeulemanPozo Mendoza Pozo MendozaPieter Van RenterghemGeert Leroux-RoelsFrans Delbeke

A1 Journal Article in Drug Testing and Analysis

The uPA(+/+)-SCID mouse with humanized liver as a model for in vivo metabolism of 4-androstene-3,17-dione

Leen LootensPeter Van EenooPhilip MeulemanGeert Leroux-RoelsFrans Delbeke

A1 Journal Article in DRUG METABOLISM AND DISPOSITION

uPA+/+-SCID mouse with humanized liver as a model for in vivo metabolism of exogenous steroids: methandienone as a case study

Leen LootensPhilip MeulemanPozo Mendoza Pozo MendozaPeter Van EenooGeert Leroux-RoelsFrans Delbeke

A1 Journal Article in CLINICAL CHEMISTRY

2008

ANTI-CD81 ANTIBODIES CAN PREVENT A HEPATITIS C VIRUS INFECTION IN VIVO

Philip MeulemanJoseph HesselgesserMatthew PaulsonThomas VanwolleghemIsabelle DesombereHans ReiserGeert Leroux-Roels

An adjuvanted, low-dose, pandemic influenza a (H5N1) vaccine candidate is safe, immunogenic, and induces cross-reactive immune responses in healthy adults

Karin LevieIsabel Leroux-RoelsKarel HoppenbrouwersAnne-Diane KervynCorinne VandermeulenSheron ForgusGeert Leroux-RoelsSylvie PichonInca Kusters

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

Anti-CD81 Antibodies Can Prevent a Hepatitis C Virus Infection In Vivo

Philip MeulemanJoseph HesselgesserMatthew PaulsonThomas VanwolleghemIsabelle DesombereIlans ReiserGeert Leroux-Roels

A1 Journal Article in HEPATOLOGY

Broad clade 2 cross-reactive immunity induced by an adjuvanted clade 1 rH5N1 pandemic influenza vaccine

Isabel Leroux-RoelsRoger BernhardPascal GérardMamadou DraméEmmanuel HanonGeert Leroux-Roels

A1 Journal Article in PLOS ONE

Development and validation of a quantitative gas chromatography-mass spectrometry method for the detection of endogenous androgens in mouse urine

Leen LootensPeter Van EenooPhilip MeulemanGeert Leroux-RoelsWim Van ThuyneFrans Delbeke

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY A

Hepatitis C virus cell-cell transmission in hepatoma cells in the presence of neutralizing antibodies

Jennifer M. TimpeZania StamatakiAdam JenningsKe HuMichelle J. FarquharHelen J. HarrisAnne SchwarzIsabelle DesombereGeert Leroux-RoelsPeter Bafe et al.

A1 Journal Article in HEPATOLOGY

Induction of a potent polyfunctional CD4+T cell response by an adjuvanted protein HIV vaccine candidate in seronegative volunteers

Eva Van BraeckelP BourguignonM KoutsoukosFrédéric ClementM JanssensI CarlettiM DemoitieG VossGeert Leroux-RoelsL McNally

Polyclonal immunoglobulins from a chronic hepatitis C virus patient protect human liver-chimeric mice from infection with a homologous hepatitis C virus strain

Thomas VanwolleghemJ BUKHPhilip MeulemanIsabelle DesombereJC MEUNIERH ALTERRH PURCELLGeert Leroux-Roels

A1 Journal Article in HEPATOLOGY

Role of the Hepatitis C Virus Core+1 Open Reading Frame and Core cis-Acting RNA Elements in Viral RNA Translation and Replication

Niki VassilakiPeter FriebePhilip MeulemanStephanie KallisArthur KaulGlaucia Paranhos-BacalaGeert Leroux-RoelsPenelope MavromaraRalf Bartenschlager

A1 Journal Article in JOURNAL OF VIROLOGY

Seasonal influenza vaccine delivered by intradermal microinjection: A randomised controlled safety and immunogenicity trial in adults

Isabel Leroux-RoelsEva VetsRalf FreeseMichael SeiberlingFrancoise WeberCamille SalamandGeert Leroux-Roels

A1 Journal Article in VACCINE

The human liver-uPA-SCID mouse: A model for the evaluation of antiviral compounds against HBV and HCV

Philip MeulemanGeert Leroux-Roels

A1 Journal Article in ANTIVIRAL RESEARCH

Vaccine Adjuvant Systems containing monophosphoryl lipid A and QS21 induce strong and persistent humoral and T cell responses against hepatitis B surface antigen in healthy adult volunteers

Pierre VandepapeliereYves HorsmansPhilippe MorisMarcelle Van MechelenMichel JanssensMarguerite KoutsoukosPascale Van BelleFrédéric ClementEmmanuel HanonMartine Wettendorff et al.

A1 Journal Article in VACCINE

Validation of the metabolism of steroids in uPA+/+-SCID mice with humanized liver

Leen LootensPeter Van EenooPozo Mendoza Pozo MendozaPhilip MeulemanGeert Leroux-RoelsFrans Delbeke

2007

Antigen sparing and cross-reactive immunity with an adjuvanted rH5N1 prototype pandemic influenza vaccine: a randomised controlled trial

Isabel Leroux-RoelsAstrid BorkowskiThomas VanwolleghemMamadou DrameFrédéric ClementEliane HonsJeanne-Marie DevasterGeert Leroux-Roels

A1 Journal Article in LANCET

Cell culture adaptation of hepatitis c virus and in vivo viability of an adapted variant

A KAULI WOERZPhilip MeulemanGeert Leroux-RoelsR BARTENSCHLAGER

A1 Journal Article in JOURNAL OF VIROLOGY

Contamination of a recombinant hepatitis B virus nucleocapsid preparation with a human B-cell activator

Peter VanlandschootFreya Van HoutteBenedikte SerruysGeert Leroux-Roels

A1 Journal Article in JOURNAL OF VIROLOGY

Expression, purification and characterization of full-length RNA-free hepatitis B core particles

K BROOSPeter VanlandschootM MARASJ ROBBENSGeert Leroux-RoelsY GUISEZ

A1 Journal Article in PROTEIN EXPRESSION AND PURIFICATION

Immunogenicity and reactogenicity of DTPw-HBV/Hib 2.5 combination vaccine: Results from four phase III multicenter trials across three continents

Eduardo Ortega-BrriaGuler KanraGeert Leroux-RoelsLulu BravoAssad SafaryInge Lefevre

A1 Journal Article in VACCINE

Increased exposure to hepatitis B virus infection in HIV-positive South African antenatal women

RJ BURNETTJM NGOBENIG FRANCOISAA HOOSENGeert Leroux-RoelsA MEHEUSMJ MPHAHLELE

A1 Journal Article in INTERNATIONAL JOURNAL OF STD & AIDS

Inhibition of replication of primary HIV-1 isolates in huPBL-NOD/Scid mice by antibodies from HIV-1 infected patients

Sophia SteyaertL HEYNDRICKXLieven VerhoyeT VERMOESENH DONNERSK FRANSENF VAN WANZEELEB VANDERGUCHTG VANHAMGeert Leroux-Roels et al.

A1 Journal Article in ANTIVIRAL RESEARCH

Long-term persistence of antibodies after one or two doses of MMR-vaccine

C VANDERMEULENM ROELANTSGeert Leroux-RoelsP VAN DARNMEK HOPPENBROUWERS

A1 Journal Article in VACCINE

Scavenger receptor BI and BII expression levels modulate hepatitis C virus infectivity

J GROVET HUBYZ STAMATAKIThomas VanwolleghemPhilip MeulemanM FARQUHARA SCHWARZM MOREAUJS OWENGeert Leroux-Roels et al.

A1 Journal Article in JOURNAL OF VIROLOGY

Serum levels of anti-NS4a and anti-NS5a predict treatment response of patients with chronic hepatitis C

Isabelle DesombereHans Van VlierbergheOla WeilandCatharina HultgrenMatti SallbergJuan QuirogaVicente CarrenoGeert Leroux-Roels

A1 Journal Article in JOURNAL OF MEDICAL VIROLOGY

Study of the human humoral immune response against envelope proteins of HIV-1 in the human PBL/SCID model

Sophia SteyaertGeert Leroux-RoelsPeter Vanlandschoot

The intraspleen huPBL NOD/SCID model to study the human HIV-specific antibody response selected in the course of natural infection

Sophia SteyaertLieven VerhoyeE BEIRNAERTH DONNERSK FRANSENL HEYNDRICKXG VANHAMGeert Leroux-RoelsPeter Vanlandschoot

A1 Journal Article in JOURNAL OF IMMUNOLOGICAL METHODS

Therapeutic vaccination of chronic hepatitis B patients with virus suppression by antiviral therapy: A randomized, controlled study of co-administration of HBsAg/AS02 candidate vaccine and lamivudine

P VANDEPAPELIEREGKK LAUGeert Leroux-RoelsY HORSMANSE GANET TAWANDEEMI BIN MERICANKM WINC TREPOG COOKSLEY et al.

A1 Journal Article in VACCINE

Ultra-rapid cardiotoxicity of the hepatitis C virus protease inhibitor BILN 2061 in the urokinase-type plasminogen activator mouse

Thomas VanwolleghemPhilip MeulemanLouis LibbrechtTania RoskamsRita De VosGeert Leroux-Roels

A1 Journal Article in GASTROENTEROLOGY

2006

Aanpak bij perinatale hepatitis C-virusinfectie

Piet VanhaesebrouckKRISTIEN ROELENSClaudine De PraeterEddy RobberechtLinde GoossensGeert Leroux-Roels

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro

BD LINDENBACHPhilip MeulemanA PLOSSThomas VanwolleghemAJ SYDERJA MCKEATINGRE LANFORDSM FEINSTONEME MAJORGeert Leroux-Roels et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human hepatocytes secrete soluble CD14, a process not directly influenced by HBV and HCV infection

Philip MeulemanSophia SteyaertLouis LibbrechtSibyl CouventFreya Van HoutteFilip ClinckspoorBernard de HemptinneTania RoskamsPeter VanlandschootGeert Leroux-Roels

A1 Journal Article in CLINICA CHIMICA ACTA

Immune suppression uncovers endogenous cytopathic effects of the hepatitis B virus

Philip MeulemanLouis LibbrechtStefan WielandRita De VosNagy HabibAnna KramvisTania RoskamsGeert Leroux-Roels

A1 Journal Article in JOURNAL OF VIROLOGY

Partial delipidation improves the T-cell antigenicity of hepatitis B virus surface antigen

Isabelle DesombereAnnick WillemsYvonne GijbelsGeert Leroux-Roels

A1 Journal Article in JOURNAL OF VIROLOGY

2005

A temperature-dependent inhibitory activity of serum on the capacity of Saccharomyces cerevisiae-derived hepatitis B surface antigen to bind to monocytes

Peter VanlandschootFreya Van HoutteA ROOBROUCKF STELTERF GAVILANESGeert Leroux-Roels

A1 Journal Article in ARCHIVES OF VIROLOGY

Comparison of qualitative (COBAS AMPLICOR HCV 2.0 versus VERSANT HCV RNA) and quantitative (COBAS AMPLICOR HCV monitor 2.0 versus VERSANT HCV RNA 3.0) assays for hepatitis c virus (HCV) RNA detection and quantification: impact on diagnosis and treatment of HCV infections

Isabelle DesombereHans Van VlierbergheSibyl CouventFilip ClinckspoorGeert Leroux-Roels

A1 Journal Article in JOURNAL OF CLINICAL MICROBIOLOGY

Development of prophylactic and therapeutic vaccines against hepatitis C virus

Geert Leroux-Roels

A1 Journal Article in EXPERT REVIEW OF VACCINES

Hepatitis B virus and human immunodeficiency virus co-infection in sub-Saharan Africa: a call for further investigation

RJ BURNETTG FRANCOISMC KEWGeert Leroux-RoelsA MEHEUSAA HOOSENMJ MPHAHLELE

A1 Journal Article in LIVER INTERNATIONAL

Immunogenicity and tolerability of intradermal administration of an HCV E1-based vaccine candidate in healthy volunteers and patients with resolved or ongoing chronic HCV infection

Geert Leroux-RoelsArsene-Helene BatensIsabelle DesombereBart Van den SteenChristine Vander SticheleGeert MaertensFrank Hulstaert

A1 Journal Article in HUMAN VACCINES

Immunostimulatory potential of hepatitis B nucleocapsid preparations: lipopolysaccharide contamination should not be overlooked

Peter VanlandschootFreya Van HouttePeter UlrichtsJan TavernierGeert Leroux-Roels

A1 Journal Article in JOURNAL OF GENERAL VIROLOGY

Morphological and biochemical characterization of a human liver in a uPA-SCID mouse chimera

Philip MeulemanLouis LibbrechtRita De VosBernard de HemptinneKris GevaertJoël VandekerckhoveTania RoskamsGeert Leroux-Roels

A1 Journal Article in HEPATOLOGY

Non-responsiveness to hepatitis B surface antigen vaccines is not caused by defective antigen presentation or a lack of B7 co-stimulation

Isabelle DesombereT CAOYvonne GijbelsGeert Leroux-Roels

A1 Journal Article in CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Potent enhancement of cellular and humoral immune responses against recombinant hepatitis B antigens using AS02A adjuvant in healthy adults

P VANDEPAPELIEREB REHERMANNM KOUTSOUKOSP MORISN GARCONM WETTENDORFFGeert Leroux-Roels

A1 Journal Article in VACCINE

Practical use of hepatitis C and B molecular tools: Belgian guidelines

M ADLERP GOUBAUGeert Leroux-RoelsD SPRENGERSJM PAWLOTSKY

A1 Journal Article in ACTA GASTRO-ENTEROLOGICA BELGICA

Safety and immunogenicity of glycoprotein D-adjuvant genital herpes vaccine

DI BernsteinFY AokiSK TyringLR StanberryC St PierreSD ShafranGeert Leroux-RoelsKoen Van HerckA BollaertsG Dubin

A1 Journal Article in CLINICAL INFECTIOUS DISEASES

The arginine-rich carboxy-terminal domain of the hepatitis B virus core protein mediates attachment of nucleocapsids to cell-surface-expressed heparan sulfate

Peter VanlandschootFreya Van HoutteBenedikte SerruysGeert Leroux-Roels

A1 Journal Article in JOURNAL OF GENERAL VIROLOGY

The duration of in vitro stimulation with recall antigens determines the subset distribution of interferon-gamma-producing lymphoid cells: A kinetic analysis using the Interferon-gamma Secretion Assay (TM)

Isabelle DesombereFrédéric ClementHanne RigoleGeert Leroux-Roels

A1 Journal Article in JOURNAL OF IMMUNOLOGICAL METHODS

2004

A candidate vaccine based on the hepatitis C E1 protein: tolerability and immunogenicity in healthy volunteers

Geert Leroux-RoelsE DEPLAF HULSTAERTL TOBBACKS DINCQJ DESMETIsabelle DesombereG MAERTENS

A1 Journal Article in VACCINE

Comparison of two qualitative and two quantitative assays for HCV RNA detection and quantification: impact on diagnosis and treatment of HCV infections

Isabelle DesombereHans Van VlierbergheSibyl CouventFilip ClinckspoorGeert Leroux-Roels

Cytopathic effects of hepatitis B virus infection in long-term infected chimeric uPA-SCID mice

Philip MeulemanL LIBBRECHTR DE VOST ROSKAMSGeert Leroux-Roels

Evidence for a relation between the viral load and genotype and hepatitis C virus-specific T cell responses

C HULTGRENIsabelle DesombereGeert Leroux-RoelsJA QUIROGAV CARRENB NILSSONO WEILANDM SALLBERG

A1 Journal Article in JOURNAL OF HEPATOLOGY

Improvement in liver histology after 3 years of E1 therapeutic vaccination in 23 patients with chronic hepatitis C

F NEVENST ROSKAMSHans Van VlierbergheY HORSMANSD SPRENGERSA ELEWAUTV DESMETGeert Leroux-RoelsA DE BRAUWERE DEPLA et al.

Morphological and biochemical characterization of a human liver in uPA-SCID mouse chimera

Philip MeulemanLouis LibbrechtRita De VosTania RoskamsGeert Leroux-Roels

Prevention of hepatitis C virus infection

M KEWG FRANCOISD LAVANCHYH MARGOLISP VAN DAMMEP GROBJ HALLAUERD SHOUVALGeert Leroux-RoelsA MEHEUS

A1 Journal Article in JOURNAL OF VIRAL HEPATITIS

Risk of hepatitis B virus infection in health care workers who are non-responders to hepatitis B vaccine

Antoon De SchryverG MOENSJ DEWIJNGAERTGeert Leroux-Roels

The interferon gamma secretion assay: a reliable tool to study interferon gamma production at the single cell level

Isabelle DesomberePhilip MeulemanHanne RigoleAnnick WillemsJ IRSCHGeert Leroux-Roels

A1 Journal Article in JOURNAL OF IMMUNOLOGICAL METHODS

Virological and morphological characterization of HBV and HCV infections in human liver-UPA-SCID mice

Philip MeulemanL LIBBRECHTR DE VOST ROSKAMSGeert Leroux-Roels

2003

A pilot study of therapeutic vaccination with envelope protein E1 in 35 patients with chronic hepatitis C

F NEVENST ROSKAMSHans Van VlierbergheY HORSMANSD SPRENGERSA ELEWAUTV DESMETGeert Leroux-RoelsE QUINAUXE DEPLA et al.

A1 Journal Article in HEPATOLOGY

A simple and rapid method to determine the zygosity of uPA-transgenic SCID mice

Philip MeulemanPeter VanlandschootGeert Leroux-Roels

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Daily induction combination treatment with alpha 2b interferon and ribavirin or standard combination treatment in naive chronic hepatitis C patients. A multicentre randomized controlled trial

Hans Van VlierbergheGeert Leroux-RoelsM ADLERN BOURGEOISF NEVENSY HORSMANSJ BROUWERIsabelle ColleJ DELWAIDER BRENARD et al.

A1 Journal Article in JOURNAL OF VIRAL HEPATITIS

Hepatitis A booster vaccination : is there a need?

P Van DammeJ BanatvalaO FayS IwarsonB McMahonKoen Van HerckD ShouvalP BonanniB ConnorG Cooksley et al.

A1 Journal Article in LANCET

Hepatitis B vaccination for sex workers: do outreach programmes perform better?

Rudolf MakA TRAENMartine ClaeyssensL VAN RENTERGHEMGeert Leroux-RoelsP VAN DAMME

A1 Journal Article in SEXUALLY TRANSMITTED INFECTIONS

Humoral and cellular immune responses to subepidermal E1-based therapeutic vaccination in healthy volunteers and patients with past or ongoing HCV infections

Geert Leroux-RoelsAH BATENSIsabelle DesombereB VAN DEN STEENCV STICHELEE D'HONDTG MAERTENSF HULSTAERT

Immunogenetics of the response to HBsAg vaccination

DR MILICHGeert Leroux-Roels

A1 Journal Article in AUTOIMMUNITY REVIEWS

Immunogenicity and reactogenicity profile of a cadidate hepatitis B vaccine in adult vaccine non-responders

G MOENSAntoon De SchryverI DESOMBEREJ DEWIJNGAERTGeert Leroux-RoelsM WETTENDORFS THOELEN

Risk of hepatitis B infeciton in health care workers who are non-responders to hepatitis B vaccine.

Antoon De SchryverG MOENSJ DEWIJNGAERTGeert Leroux-Roels

Risk of hepatitis B infection in health care workers who are non-responders to hepatitis B vaccine

Antoon De SchryverG MOENSJ DE WIJNGAERTGeert Leroux-Roels

Saccharomyces cerevisiae-derived HBsAg preparations differ in their attachment to monocytes, immune-suppressive potential, and T-cell immunogenicity

Peter VanlandschootFreya Van HoutteF HOEKR NIEUWLANDGeert Leroux-Roels

A1 Journal Article in JOURNAL OF MEDICAL VIROLOGY

Soluble CD14 levels are increased and inversely correlated with the levels of hepatitis B surface antigen in chronic hepatitis B patients

Sophia SteyaertPeter VanlandschootHans Van VlierbergheH DIEPOLDERGeert Leroux-Roels

A1 Journal Article in JOURNAL OF MEDICAL VIROLOGY

The nucleocapsid of the hepatitis B virus: a remarkable immunogenic structure

Peter VanlandschootTH CAOLGeert Leroux-Roels

A1 Journal Article in ANTIVIRAL RESEARCH

The use of saliva and sweat for the detection of abused drugs in drivers

Nele SamynAlain VerstraeteGeert Leroux-Roels

Viral apoptotic mimicry: an immune evasion strategy developed by the hepatitis B virus?

Peter VanlandschootGeert Leroux-Roels

A1 Journal Article in TRENDS IN IMMUNOLOGY

2002

Characterization of HLA DR13-restricted CD4(+) T cell epitopes of hepatitis B core antigen associated with self-limited, acute hepatitis B.

Tinghua CaoIsabelle DesomberePeter VanlandschootM SALLBERGGeert Leroux-Roels

A1 Journal Article in JOURNAL OF GENERAL VIROLOGY

Evaluation of a new rapid test for the combined detection of hepatitis B virus surface antigen and hepatitis B virus e antigen

Frédéric ClementPieter DewintGeert Leroux-Roels

A1 Journal Article in JOURNAL OF CLINICAL MICROBIOLOGY

Evolution of hepatitis C virus-specific T cell responses and cytokine production in chronic hepatitis C patients treated with high doses of interferon-alpha.

CA ESQUIVELA ELEWAUTJan PhilippéAE ELEWAUTIsabelle DesombereG MAERTENSGeert Leroux-Roels

A1 Journal Article in REVISTA DE INVESTIGACION CLINICA

Features of the CD4(+) T-cell response in liver and peripheral blood of hepatitis C virus-infected patients with persistently normal and abnormal alanine aminotransferase levels.

MA RICOJA QUIROGAD SUBIRAE GARCIAS CASTANONM SALLBERGGeert Leroux-RoelsO WEILANDM PARDOV CARRENO

A1 Journal Article in JOURNAL OF HEPATOLOGY

Hepatitis B virus surface antigen suppresses the activation of monocytes through interaction with a serum protein and a monocyte-specific receptor.

Peter VanlandschootF VAN HOUTTEAnnelies RoobrouckA FARHOUDIGeert Leroux-Roels

A1 Journal Article in JOURNAL OF GENERAL VIROLOGY

Immune response of HLA DQ2 positive subjects, vaccinated with HBsAg/ASO4, a hepatitis B vaccine with a novel adjuvant.

Isabelle DesombereM VAN DER WIELENP VAN DAMMEM STOFFELN DE CLERCQC GOILAVGeert Leroux-Roels

A1 Journal Article in VACCINE

LPS-binding protein and CD14-dependent attachment of hepatitis B surface antigen to monocytes is determined by the phospholipid moiety of the particles.

Peter VanlandschootF VAN HOUTTEAnnelies RoobrouckA FARHOUDIF STELTERDL PETERSONJ GOMEZ-GUTIERREZF GAVILANESGeert Leroux-Roels

A1 Journal Article in JOURNAL OF GENERAL VIROLOGY

Non-transferrin-bound iron in chronic hepatitis C.

Hans Van VlierbergheH VERDIEVELI COLLEJoris DelangheGeert Leroux-RoelsMartine De Vos

Non-transferrin-bound iron in untreated and ribavirin-treated chronic hepatitis C patients

Hans Van VlierbergheHugo VerdievelIsabelle ColleJoris DelangheMarleen PraetD BERNARDGeert Leroux-RoelsMartine De Vos

A1 Journal Article in ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Recombinant HBsAg, an apoptotic-like lipoprotein, interferes with the LPS-induced activation of ERK-1/2 and JNK-1/2 in monocytes.

Peter VanlandschootAnnelies RoobrouckF VAN HOUTTEGeert Leroux-Roels

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The immunogenicity and reactogenicity profile of a candidate hepatitis B vaccine in an adult vaccine non-responder population.

P JACQUESG MOENSIsabelle DesombereJ DEWIJNGAERTGeert Leroux-RoelsM WETTENDORFFS THOELEN

A1 Journal Article in VACCINE

2001

A candidate therapeutic vaccine for chronic hepatitis C infection based on envelope 1 protein: Tolerability and immunogenicity in healthy adult volunteers

Geert Leroux-RoelsE DEPLAF HULSTAERTJ DE SMEDTIsabelle DesombereG MAERTENS

Association between Cys282Tyr missense mutation and haptoglobin phenotype polymorphism in patients with chronic hepatitis C.

Hans Van VlierbergheJR DELANGHESylvia De BieMarleen PraetAnne De PaepeLudwine MessiaenMartine De VosGeert Leroux-Roels

A1 Journal Article in EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Factors influencing ribavirin-induced hemolysis.

Hans Van VlierbergheJoris DelangheMartine De VosGeert Leroux-Roels

A1 Journal Article in JOURNAL OF HEPATOLOGY

Haptoglobin phenotype 2-2 overrepresentation in Cys282Tyr hemochromatotic patients

Hans Van VlierbergheMichel LangloisJoris DelangheY HORSMANSP MICHIELSENJ HENRIONR CARTUYVELSJ BILLIETMartine De VosGeert Leroux-Roels

A1 Journal Article in JOURNAL OF HEPATOLOGY

Hepatitis B virus core antigen binds and activates naive human B cells in vivo: Studies with a human PBL-NOD/SCID mouse model.

Tinghua CaoU LAZDINAIsabelle DesomberePeter VanlandschootDR MILICHM SALLBERGGeert Leroux-Roels

A1 Journal Article in JOURNAL OF VIROLOGY

Human B cell growth and differentiation in the spleen of immunodeficient mice.

Stany DepraetereL VERHOYEGeorges LeclercqGeert Leroux-Roels

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Humoral and CD4(+) T helper (Th) cell responses to the hepatitis C virus non-structural 3 (NS3) protein: NS3 primes Th 1-like responses more effectively as a DNA-based immunogen than as a recombinant protein.

U LAZDINAC HULTGRENL FRELINM CHENK LODINO WEILANDGeert Leroux-RoelsJA QUIROGADL PETERSONDR MILICH et al.

A1 Journal Article in JOURNAL OF GENERAL VIROLOGY

In vivo inhibition of anti-HBcIgG production by HBcAg-specific CD4+Th1-type T cell clones in a hu-PBL-NOD/SCID mice model

TH CAOPhilip MeulemanIsabelle DesombereM SALLBERGGeert Leroux-Roels

In vivo inhibition of anti-hepatitis B virus core antigen (HBcAg) immunoglobulin G production by HBcAg-specific CD4(+) Th1-type T-cell clones in a hu-PBL-NOD/SCID mouse model.

Tinghua CaoPhilip MeulemanIsabelle DesombereM SALLBERGGeert Leroux-Roels

A1 Journal Article in JOURNAL OF VIROLOGY

Long-term persistence of antibodies induced by vaccination and safety follow-up, with the first combined vaccine against hepatitis A and B in children and adults

P Van DammeGeert Leroux-RoelsB LawF Diaz-MitomaIsabelle DesombereF CollardN TornieporthKoen Van Herck

A1 Journal Article in JOURNAL OF MEDICAL VIROLOGY

Molecular basis for the interaction of the hepatitis B virus core antigen with the surface immunoglobulin receptor on naive B cells.

U LAZDINATinghua CaoJ STEINBERGSM ALHEIMP PUMPENSDL PETERSONDR MILICHGeert Leroux-RoelsM SALLBERG

A1 Journal Article in JOURNAL OF VIROLOGY

Prevention of hepatitis B infections: Vaccination and its limitations

Geert Leroux-RoelsT CAOA DE KNIBBERPhilip MeulemanA ROOBROUCKA FARHOUDIPeter VanlandschootIsabelle Desombere

A1 Journal Article in ACTA CLINICA BELGICA

The human immune response to the hepatitis B core protein : studies in vitro and in the huPBL-scid mouse model

Tinghua CaoGeert Leroux-Roels

Vaccine- and hepatitis B immune globulin-induced escape mutations of hepatitis B virus surface antigen.

MP COOREMANGeert Leroux-RoelsWP PAULIJ

A1 Journal Article in JOURNAL OF BIOMEDICAL SCIENCE

2000

A comparison of two commercial recombinant vaccines for hepatitis B in adolescents.

Geert Leroux-RoelsB ABRAHAMM FOURNEAUN DE CLERCQA SAFARY

A1 Journal Article in VACCINE

A hepatitis B vaccine formulated with a novel adjuvant system.

F AMBROSCHG WIEDERMANNM KUNDIGeert Leroux-RoelsIsabelle DesombereN GARCONC THIRIARTM SLAOUIS THOELEN

A1 Journal Article in VACCINE

Antigen-specific T cell responses in human peripheral blood leucocyte (hu-PBL)-mouse chimera conditioned with radiation and an antibody directed against the mouse IL-2 receptor beta-chain.

Tinghua CaoGeert Leroux-Roels

A1 Journal Article in CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Association between the Cys282Tyr missense mutation and the haptoglobin phenotype polymorphism in patients with chronic hepatitis C

Hans Van VlierbergheLudwine MessiaenAnne De PaepeJoris DelangheMarleen PraetM De VosGeert Leroux-Roels

Characterization of the T cell recognition of hepatitis B surface antigen (HBsAg) by good and poor responders to hepatitis B vaccines

Isabelle DesombereYvonne GijbelsAndréa VerwulgenGeert Leroux-Roels

A1 Journal Article in CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Effects of re-arterialization on early graft function and regeneration in the rat model of heterotopic auxiliary liver transplantation.

YD FANMarleen PraetBart VanzieleghemD VANWYNSBERGHED STOOPGeert Leroux-RoelsJoris DelangheBernard de Hemptinne

A1 Journal Article in EUROPEAN SURGICAL RESEARCH

Hepatitis in dialysis.

Geert Leroux-RoelsAnnemieke Dhondt

Bookchapter in Complications of Dialysis / Editors : N. Lameire, R.L. Mehta. - New York : Marcel Dekker Incorporation, 2000. - ISBN 0-8247-8871-0

Infections in IVF: review and guidelines.

SR STEYAERTGeert Leroux-RoelsMarc Dhont

A1 Journal Article in HUMAN REPRODUCTION UPDATE

Line probe assay for monitoring drug resistance in hepatitis B virus-infected patients during antiviral therapy

Lieven StuyverCaroline Van GeytSija De GendtGeorges Van ReybroeckFabien ZoulimGeert Leroux-RoelsRudi Rossau

A1 Journal Article in JOURNAL OF CLINICAL MICROBIOLOGY

Long term response to interferon treatment in chronic hepatitis C patients is associated with a significant reduction in anti-E1 envelope antibody titers.

Stany DepraetereE VAN KERSCHAEVERHV VLIERBERGHEA ELEWAUTJT BROUWERH NIESTERSSW SCHALMG MAERTENSGeert Leroux-Roels

A1 Journal Article in JOURNAL OF MEDICAL VIROLOGY

Mouse strain and conditioning regimen determine survival and function of human leucocytes in immunodeficient mice.

Kurt TournoyStany DepraetereRomain PauwelsGeert Leroux-Roels

A1 Journal Article in CLINICAL AND EXPERIMENTAL IMMUNOLOGY

1999

De immunologie van Multiple Sclerose.

J PHILIPPEJan DebruyneGeert Leroux-Roels

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Evaluation of graft viability in heterotopic auxiliary liver transplantation in the rat.

Yedong FanGeert Leroux-RoelsMarleen PraetUwe HesseBernard de Hemptinne

A1 Journal Article in JOURNAL OF INVESTIGATIVE SURGERY

The first combined vaccine against hepatitis A and B : an overview

S THOELENPetra Van DammeA LEENTVAAR-KUYPERSGeert Leroux-RoelsM BRUGUERAPC FREIV BAKASENASA SAFARY

A1 Journal Article in VACCINE

1998

Diagnostic performance of the EMIT-tox (R) benzodiazepine immunoassay, FPIA serum benzodiazepine immunoassay, and radioreceptor assay in suspected acute poisoning.

Alain VerstraeteFrans BelpaireGeert Leroux-Roels

A1 Journal Article in JOURNAL OF ANALYTICAL TOXICOLOGY

HBV-specific lymphoproliferative and cytokine responses in patients with chronic hepatitis B

Johan VingerhoetsPeter MichielsenGuido VanhamEugène BosmansWilma PaulijAlbert RamonPaul PelckmansLuc KestensGeert Leroux-Roels

A1 Journal Article in JOURNAL OF HEPATOLOGY

Het klinisch verloop van acute virale hepatitis bij kinderen.

Eddy RobberechtP DESMETK MEKEIRELEGeert Leroux-Roels

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Human immune response to envelope proteins of the hepatitis B virus.

Isabelle DesombereGeert Leroux-Roels

Murine IL-2 receptor beta chain blockade improves human leukocyte engraftment in SCID mice

Kurt TournoyStany DepraeterePhilip MeulemanGeert Leroux-RoelsRomain Pauwels

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Partial delipidation improves the T cell immunogenicity of hepatitis B surface antigen

Isabelle DesombereGeert Leroux-RoelsM WETTENDORFAnnick WillemsYvonne GijbelsAndréa Verwulgen

Relapse markers in multiple sclerosis: are in vitro cytokine production changes reflected by circulatory T-cell phenotype alterations?

Jan DebruyneJan PhilippéJacques De ReuckA WILLEMSGeert Leroux-Roels

A1 Journal Article in MULTIPLE SCLEROSIS

Response to hepatitis B vaccine: Multiple HLA genes are involved

Isabelle DesombereAnnick WillemsGeert Leroux-Roels

Response to hepatitis B vaccine: multiple HLA genes are involved

Isabelle DesombereAnnick WillemsGeert Leroux-Roels

A1 Journal Article in TISSUE ANTIGENS

Safety and immunogenicity of a hepatitis B vaccine formulated with a novel adjuvant system.

S THOELENP VAN DAMMEC MATHEIGeert Leroux-RoelsIsabelle DesombereA SAFARYP VANDEPAPELIEREM SLAOUIA MEHEUS

A1 Journal Article in VACCINE

Serum creatine kinase activity is not a reliable marker for muscle damage in conditions associated with low extracellular glutathione concentration

J GunstMichel LangloisJoris DelangheMarc De BuyzereGeert Leroux-Roels

A1 Journal Article in CLINICAL CHEMISTRY

Ultrarapid hepatitis C virus clearance by daily high-dose interferon in non-responders to standard therapy

FC BEKKERINGJT BROUWERGeert Leroux-RoelsHans Van VlierbergheAndré ElewautSW SCHALM

A1 Journal Article in JOURNAL OF HEPATOLOGY

Virale hepatitis van A tot G: diagnostische aspecten

Geert Leroux-RoelsL Van Renterghem

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

1997

A single approach to the prevention of Hepatitis A and B

Geert Leroux-Roels

Antibodies to E1 and E2 in chronic HCV patients with a long-term response to interferon therapy

Stany DepraetereE Van KerschaverHans Van VlierbergheAndré ElewautE DeplaG MaertensGeert Leroux-Roels

Antibodies to E1 and E2 in patients infected with HCV1b : correlation with response to interferon therapy

Stany DepraetereE Van KerschaverAndré ElewautJ BrouwerB NiestersS SchalmG MaertensGeert Leroux-Roels

Antibodies to E1 and E2 in patients infected with HCV1b : evolution of antibody levels after interferon therapy

Stany DepraetereE Van KerschaverAndré ElewautJ BrouwerB NiestersS SchalmG MaertensGeert Leroux-Roels

Cytotoxic T lymphocytes in HBV and HCV infections: beneficial or harmful ?

Geert Leroux-RoelsIsabelle DesombereS DEPRAETEREC TINGHUAE VAN KERSCHAVER

A2 Journal Article in Central-European Journal of Immunology

Distribution of lymphocyte subsets in bone marrow and peripheral blood is associated with haptoglobin type - Binding of haptoglobin to the B-cell lectin CD22.

Michel LangloisJoris DelangheJan PhilippéJin OuyangD BERNARDMarc De BuyzereG VANNOOTENGeert Leroux-Roels

A1 Journal Article in EUROPEAN JOURNAL OF CLINICAL CHEMISTRY AND CLINICAL BIOCHEMISTRY

Early disappearance of HCV RNA is a prognostic marker of sustained response during retreatment of hepatitis C non sustained responders

Hans Van VlierbergheA ElewautFC BekkeringJT BrouwerGeert Leroux-RoelsS SchalmAndré Elewaut

Hepatitis B vaccine containing surface antigen and selected preS1 and preS2 sequences .1. Safety and immunogenicity in young, healthy adults.

Geert Leroux-RoelsIsabelle DesombereG DETOLLENAEREMA PETITP DESMONSP HAUSERA DELEMD DEGRAVEA SAFARY

A1 Journal Article in VACCINE

Hepatitis B vaccine containing surface antigen and selected preS1 and preS2 sequences .2. Immunogenicity in poor responders to hepatitis B vaccines.

Geert Leroux-RoelsIsabelle DesombereL COBBAUTMA PETITP DESMONSP HAUSERA DELEMD DEGRAVEA SAFARY

A1 Journal Article in VACCINE

High-dose interferon alfa 2B retreatment in hepatitis C positive non IB non-responders : results in a high percentage of sustained response

Hans Van VlierbergheAE ElewautGeert Leroux-RoelsAndré Elewaut

Interleukin-12 induces responses to HBsAg in chronic HBV carriers

J VingerhoetsP MichielsenG VanhamE BosmansW PaulijA RamonP PelckmansL KestensGeert Leroux-Roels

Is angiotensin-converting enzyme I/D polymorphism involved in cardiovascular complications in essential hypertension ?

Marc De BuyzereB WUYTSJ DELANGHEDaniel DuprezGeert Leroux-RoelsDenis Clement

A2 Journal Article in Am. College of Cardiology, 29, suppl. A, 83A

Prevalence of GBV-C/HGV and HCV in 4 hemodialysis units in Flanders (Belgium)

Annelies RoobrouckStany DepraetereS CouventE Van KerschaeverG MaertensGeert Leroux-Roels

Prevalence of GBV-C/HGV and new HCV markers in healthy, voluntary blood donors with elevated ALT levels of 'unknown' origin

Annelies RoobrouckStany DepraetereS CouventE Van KerschaeverH Van DurmeB VandekerckhoveG MaertensF De KeyserE StoopsM Zrein et al.

Relationschip of decreased chemotaxis of technetium-99-m-HMPAO-labeled lymphocytes to apoptosis

Christophe Van De WieleJan PhilippéJP VAN HAELSTJozef Van DammeHubert ThierensGeert Leroux-RoelsRudi Dierckx

A2 Journal Article in Journal Nuclear Medicine, nr. 38, pp. 1417-1421, 2 figg

Relationship of decreased chemotaxis of technetium-99m-HMPAO-labeled lymphocytes to apoptosis

C Van de WieleJan PhilippéJP Van HaelstJozef Van DammeHubert ThierensGeert Leroux-RoelsRudi Dierckx

A1 Journal Article in JOURNAL OF NUCLEAR MEDICINE

Rubella en toxoplasma: immuunstatus bij meisjes van 12 tot 18 jaar

Geert Leroux-Roels

A4 Journal Article in VAX INFO (NEDERLANDSE EDITIE)

Ultrarapid hepatitis C virus clearance by daily high dose interferon in nonreponders to standard therapy

FC BekkeringJT BrouwerGeert Leroux-RoelsHans Van VlierbergheAndré ElewautS Schalm

1996

Comparison of a recombinant thromboplastin with Thrombotest(TM) for oral anticoagulant control.

Gaston BaeleT FIERSGeert Leroux-Roels

A1 Journal Article in HAEMOSTASIS

De immuunstatus voor Rubella en Toxoplasma bij meisjes van 12 tot 18 jaar.

K VANDEKERCKHOVEAlain VerstraeteGeert Leroux-Roels

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Genetic polymorphisms and erythrocyte sodium-lithium countertransport in essential hypertension

Kurt TournoyJoris DelangheDaniel DuprezMarc De BuyzereRonald VerbeeckDonald A VergauweGeert Leroux-RoelsDenis Clement

A1 Journal Article in CLINICA CHIMICA ACTA

Haptoglobin polymorphism and chronic hepatitis C.

HK LOUAGIEJT BROUWERJoris DelangheMarc De BuyzereGeert Leroux-Roels

A1 Journal Article in JOURNAL OF HEPATOLOGY

Hepatitis C virus (HCV) genotype analysis in apparently healthy anti-HCV-positive Parisian blood donors.

L STUYVERC ESQUIVELA BOUDIFAD JAULMESN AZARF LUNELGeert Leroux-RoelsG MAERTENSJJ FOURNEL

A1 Journal Article in TRANSFUSION

Hepatitis C virus in a hemodialysis unit: Molecular evidence for nosocomial transmission.

L STUYVERH CLAEYSA WYSEURW VANARNHEMH DEBEENHOUWERS UYTENDAELEJ BECKERSD MATTHIJSGeert Leroux-RoelsG MAERTENS et al.

A1 Journal Article in KIDNEY INTERNATIONAL

In vitro TNF-alpha, IL-2 and IFN-gamma production as markers of relapses in multiple sclerosis.

Jan PhilippéJan DebruyneGeert Leroux-RoelsA WILLEMSJacques De Reuck

A1 Journal Article in CLINICAL NEUROLOGY AND NEUROSURGERY

Influence of combinations of HLA class II genes on the human immune response to hepatitis B vaccine

Isabelle DesombereGeert Leroux-Roels

Interference of soluble TNF-alpha receptors in immunological detection of tumor necrosis factor-alpha.

E MOREAUJan PhilippéS COUVENTGeert Leroux-Roels

A1 Journal Article in CLINICAL CHEMISTRY

Lymphoproliferative responses to hepatitis C virus core, E1, E2, and NS3 in patients with chronic hepatitis C infection treated with interferon alfa.

Geert Leroux-RoelsCA ESQUIVELR DELEYSL STUYVERAndré ElewautJan PhilippéIsabelle DesombereJoseph ParadijsG MAERTENS

A1 Journal Article in HEPATOLOGY

Prognostic markers in septic shock

Jan PhilippéFritz OffnerGaston BaeleGeert Leroux-Roels

Quantitative nephelometric assay for determining alpha-foetoprotein evaluated.

DR BERNARDJoris DelangheMarc De BuyzereGeert Leroux-Roels

A1 Journal Article in EUROPEAN JOURNAL OF CLINICAL CHEMISTRY AND CLINICAL BIOCHEMISTRY

Safety and immunogenicity of a combined hepatitis A and hepatitis B vaccine in young healthy adults.

Geert Leroux-RoelsE MOREAUIsabelle DesombereA SAFARY

A1 Journal Article in SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

1995

ANALYSIS OF THE ANTI-HBS RESPONSE OF ELDERLY SUBJECTS TO HBV VACCINE

Isabelle DesombereLuc CobbautM SLAOUIGeert Leroux-Roels

Cytokines in vaccine research

Geert Leroux-RoelsIsabelle DesombereJ PARADIJSJ VINGERHOETSJan Philippé

A4 Journal Article in Cytokine News - Medgenix Diagnostics

Evolution of HCV-specific T cell responses and in vivo and in vitro TNF-alpha and interferon-gamma production in chronic HCV patients treated with high doses of interferon-beta

C ALVARADO-ESQUIVELJ PHILIPPEAndré ElewautJ PARADIJSR DELEYSL STUYVERG MAERTENSGeert Leroux-Roels

A2 Journal Article in Gastroenterology, 108, A1026

FLOW-CYTOMETRY TO OVERCOME INTERFERENCES IN IMPEDANCE-BASED LEUKOCYTE COUNTING.

H LOUAGIEE MOREAUJan PhilippéGeert Leroux-Roels

A1 Journal Article in CLINICAL CHEMISTRY

MN blood-group, a genetic-marker for essential arterial-hypertension in young-adults.

Joris DelangheDaniel DuprezMarc De BuyzereD ROBBRECHTB BERGEZGeert Leroux-RoelsDenis Clement

A1 Journal Article in EUROPEAN HEART JOURNAL

NONRESPONDERS TO HEPATITIS-B VACCINE CAN PRESENT ENVELOPE PARTICLES TO T-LYMPHOCYTES

Isabelle DesombereP HAUSERR ROSSAUJ PARADIJSGeert Leroux-Roels

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Refractory hypertension is associated with haptoglobin 2-2 phenotype

J DELANGHEDaniel DuprezMarc De BuyzereD ROBBRECHTB BERGEZGeert Leroux-RoelsDenis Clement

A2 Journal Article in Journal Cardiovasc. Risk, 2

Sodium-lithium countertransport and vitamin D binding protein polymorphism in essential arterial hypertension.

K TOURNOYJ DELANGHEDaniel DuprezMarc De BuyzereF CLEMENTDenis ClementR VERBEECKGeert Leroux-Roels

A2 Journal Article in Acta Clinica

1994

A method to detect Hepatitis B virus-specific cytotoxic T lymphocytes in patients with acute and chronic HBV infection

Geert Leroux-RoelsEls Van HeckeJoseph ParadijsChantal MolitorCarine BastinPietro PalaMoncef Slaoui

Bookchapter in Viral hepatitis and liver disease

COLORIMETRIC QUANTIFICATION OF URINARY IRON DURING DEFEROXAMINE THERAPY.

Bruno VerhasseltJoris DelangheAlain VerstraeteGeert Leroux-Roels

A1 Journal Article in CLINICAL CHEMISTRY

CORRELATION BETWEEN IN-VIVO HUMORAL AND IN-VITRO CELLULAR IMMUNE-RESPONSES FOLLOWING IMMUNIZATION WITH HEPATITIS-B SURFACE-ANTIGEN (HBSAG) VACCINES.

Geert Leroux-RoelsE VANHECKEWalter MichielsenP VOETP HAUSERJ PETRE

A1 Journal Article in VACCINE

Deficient T-cell responses in non-responders to hepatitis-B vaccination: absence of Thl cytokine production.

J VINGERHOETSG VANHAML KESTENSG PENNEGeert Leroux-RoelsPaul Gigase

A1 Journal Article in IMMUNOLOGY LETTERS

Glomerular filtration rate and creatinine production in adult icteric patients.

Joris DelangheHK LOUAGIEMarc De BuyzereGeert Leroux-Roels

A1 Journal Article in CLINICA CHIMICA ACTA

Hepatitis-B virus-specific cytotoxic T-lymphocyte responses in patients with acute and chronic-B virus-infection.

E VANHECKEJoseph ParadijsC MOLITORC BASTINP PALAM SLAOUIGeert Leroux-Roels

A1 Journal Article in JOURNAL OF HEPATOLOGY

Increased platelet response to ADP-stimulation in vitro in peripheral arterial occlusive disease after treadmill exercise

S VERSCHUERENJan PhilippéDaniel DuprezMarc De BuyzereGeert Leroux-Roels

MN blood group, a genetic marker for essential arterial hypertension

J DELANGHEDaniel DuprezMarc De BuyzereD ROBBRECHTGeert Leroux-RoelsDenis Clement

A2 Journal Article in J. Hypertens., 12, S3, nr. 1618

PERFORMANCE OF THE COULTER STKS AND THE SYSMEX-NE-1500 IN A PEDIATRIC POPULATION.

E MOREAUJan PhilippéJozef KintYves BenoitGeert Leroux-Roels

A1 Journal Article in EUROPEAN JOURNAL OF CLINICAL CHEMISTRY AND CLINICAL BIOCHEMISTRY

Posttranslational heterogeneity of bone alkaline-phosphatase in metabolic bone-disease.

Michel LangloisJoris DelangheJean KaufmanMarc De BuyzereMJ VANHOECKEGeert Leroux-Roels

A1 Journal Article in EUROPEAN JOURNAL OF CLINICAL CHEMISTRY AND CLINICAL BIOCHEMISTRY

T-CELL EPITOPES OF HEPATITIS-B VIRUS ENVELOPE GLYCOPROTEINS (HBV-ENV) RECOGNIZED BY GOOD RESPONDERS TO HBV-ENV VACCINES

Geert Leroux-RoelsIsabelle DesombereP VOETJ PETREP HAUSER

T-lymphocyte response to core, El, E2 and NS 3 in chronic HCV patients treated with interferon-alpha

Geert Leroux-RoelsC ALVARADO-ESQUIVELB DELEYSL STUYVERG MAERTENSAndré Elewaut

A2 Journal Article in Gastroenterology, 106, A928

Waarom wordt een hepatitis B virus infectie soms chronisch ?

Geert Leroux-RoelsIsabelle DesombereJ PARADIJSAndré Elewaut

A4 Journal Article in Roche in Virology

1993

Biological evaluation of endothelial damage in established peripheral arterial occlusive disease.

Marc De BuyzereDaniel DuprezG BAELEJ PHILIPPEGeert Leroux-Roels

A2 Journal Article in ACTA CARDIOLOGICA

Changes in platelet number and function in peripheral arterial occlusive disease

Jan PhilippéS VanderschuerenMarc De BuyzereDaniel DuprezGaston BaeleGeert Leroux-Roels

Estimation of glomerular filtration rate in icteric patients

Henk LouagieJoris DelangheMarc De BuyzereGeert Leroux-Roels

Flow cytometric detection of platelet response to ADP in peripheral arterial occlusive disease after treadmill exercise

S VanderschuerenJan PhilippéMarc De BuyzereDaniel DuprezGeert Leroux-Roels

HAPTOGLOBIN POLYMORPHISM AND COMPLICATIONS IN ESTABLISHED ESSENTIAL ARTERIAL-HYPERTENSION.

Joris DelangheDaniel DuprezMarc De BuyzereBM BERGEZBY CALLENSGeert Leroux-RoelsDenis Clement

A1 Journal Article in JOURNAL OF HYPERTENSION

HAPTOGLOBIN POLYMORPHISM AND THE IMMUNE-RESPONSE AFTER HEPATITIS-B VACCINATION.

H LOUAGIEJoris DelangheIsabelle DesombereMarc De BuyzereP HAUSERGeert Leroux-Roels

A1 Journal Article in VACCINE

Haptoglobin polymorphism and peripheral arterial occlusive disease

Joris DelangheDaniel DuprezMarc De BuyzereB CallensB BergezGeert Leroux-RoelsDenis Clement

A2 Journal Article in ACTA CARDIOLOGICA

Haptoglobin polymorphism and the immune response after hepatitis B vaccination

H LOUAGIEJoris DelangheGeert Leroux-Roels

A2 Journal Article in Eur. J. Clin. Chem. Clin. Biochem., 31, p. A4

Immunogenicity of a new hepatitis B vaccine containing preS1 and preS2 epitopes

Geert Leroux-RoelsIsabelle DesombereP HAUSERP DEGRAVEJ PETREP VANDEPAPELIEREA SAFARY

Increased plasma-levels of molecular markers of coagulation activation and secondary fibrinolysis in peripheral arterial occlusive disease

Gaston BaeleMarc De BuyzereJan PhilippéDaniel DuprezDenis ClementGeert Leroux-Roels

Laboratory assessment of five glucose meters designed for self-monitoring of Blood-Glucose Concentration.

K DEVREESEGeert Leroux-Roels

A1 Journal Article in EUROPEAN JOURNAL OF CLINICAL CHEMISTRY AND CLINICAL BIOCHEMISTRY

MN blood group, a genetic marker for arterial blood pressure height and body mass index in treated essential hypertension.

J DELANGHEDaniel DuprezD ROBBRECHTMarc De BuyzereGeert Leroux-RoelsDenis Clement

A2 Journal Article in ACTA CARDIOLOGICA

MN blood group, a genetic marker for arterial pressure height and body mass index in treated essential hypertension

J DELANGHEDaniel DuprezD ROBBRECHTMarc De BuyzereDenis ClementGeert Leroux-Roels

A2 Journal Article in American Journal Hypertension, 6, nr. 5, part 2, nr. 1254

MN blood group, a genetic marker for essential arterial hypertension.

J DELANGHEDaniel DuprezMarc De BuyzereD ROBBRECHTB BERGEZGeert Leroux-RoelsDenis Clement

A2 Journal Article in ACTA CLINICA BELGICA

MN bloodgroup, a genetic marker for arterial blood pressure height and body mass index in treated essential hypertension.

Joris DelangheDaniel DuprezD ROBBRECHTMarc De BuyzereGeert Leroux-Roels

A2 Journal Article in ACTA CARDIOLOGICA

MN bloodgroup, a genetic marker for arterial pressure height and body mass index in treated essential hypertension

Joris DelangheDaniel DuprezD ROBBRECHTMarc De BuyzereDenis ClementGeert Leroux-Roels

A2 Journal Article in American Journal Hypertension, 6, 1993, p. 87 A. & Sixth European Meeting on Hypertension. European Society of Hyper tension. Milaan, June 4th-7th, p. 175

NONRESPONDERS TO HEPATITIS-B VACCINE CAN PRESENT HBSAG TO T-LYMPHOCYTES

Geert Leroux-RoelsIsabelle DesombereP VOETP HAUSER

Platelet response to ADP as detected by flow cytometry in peripheral arterial occlusive disease after treadmill exercise.

S VANDERSCHUERENJ PHILIPPEMarc De BuyzereDaniel DuprezGeert Leroux-Roels

A2 Journal Article in ACTA CARDIOLOGICA

Simple flow cytometric detection of platelet activation

S VANDERSCHUERENJan PhilippéMarc De BuyzereDaniel DuprezGeert Leroux-Roels

A2 Journal Article in EUT. J. Clin. Chem. Clin. Biochem., 31, nr. 4, A8

Studie van het humaan immuunantwoord tegen hepatitis B virus

Els Van HeckeGeert Leroux-RoelsWalther Fiers

T-cell recognition of hepatitis C virus in patients with chronic hepatitis C

C ALVARADO-ESQUIVELAndré ElewautR DELEYSG MAERTENSGeert Leroux-Roels

A2 Journal Article in Gastroenterology, 104, A660

Waarom wordt een hepatitis B virus infectie soms chronisch ?

Geert Leroux-RoelsIsabelle DesombereJ PARADYSAndré Elewaut

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

1992

Activation of the clotting cascade in peripheral arterial occlusive disease. Abstract of the 12th International Congress on Thrombosis

Marc De BuyzereDaniel DuprezDenis ClementGaston BaeleGeert Leroux-Roels

Basal fibrinolysis in essential hypertension and peripheral arterial disease

J PHILIPPEDaniel DuprezMarc De BuyzereG BAELEGeert Leroux-RoelsDenis Clement

De 'nieuwere' tumormerkers.

E DE LOGIGeert Leroux-Roels

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

De rol van het klinisch laboratorum bij de evaluatie van metastasen van onbekende oorsprong.

Geert Leroux-RoelsE DE LOGI

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Fibrinolytische parameters tijdens coronaire angioplastiek

A WEYNEMarc De BuyzereJ PHILIPPEG BAELEGeert Leroux-RoelsDenis Clement

GLYCATION OF HUMAN TISSUE AND SERUM CREATINE-KINASE.

Michel LangloisJoris DelangheMarc De BuyzereGeert Leroux-Roels

A1 Journal Article in CLINICA CHIMICA ACTA

GRANULOCYTE ELASTASE, TUMOR-NECROSIS-FACTOR-ALPHA AND UROKINASE LEVELS AS PROGNOSTIC MARKERS IN SEVERE INFECTION.

Jan PhilippéG DOOIJEWAARDFritz OffnerP TURIONGaston BaeleGeert Leroux-Roels

A1 Journal Article in THROMBOSIS AND HAEMOSTASIS

Glycation of human tissue and serum creatine kinase

Michel LangloisJoris DelangheMarc De BuyzereGeert Leroux-Roels

A2 Journal Article in Clin. Chim. Acta, 211

Haptoglobin 2-2, a genetic marker for therapy resistance in established essential hypertension

Joris DelangheDaniel DuprezMarc De BuyzereGeert Leroux-RoelsDenis Clement

Haptoglobin 2-2, a genetic marker for therapy resistance in established essential hypertension

Joris DelangheDaniel DuprezMarc De BuyzereB BergezGeert Leroux-RoelsDenis Clement

Haptoglobin 2-2, a genetic marker for therapy resistance in established essential hypertension. Eur. Heart J., 1992, 13 (Abstract Supplement), p. 85.

Joris DelangheDaniel DuprezMarc De BuyzereB BergezGeert Leroux-RoelsDenis Clement

Haptoglobin phenotype 2-2: agenetic marker for therapy - resistant essential hypertension

J DELANGHEDaniel DuprezMarc De BuyzereGeert Leroux-RoelsDenis Clement

Hepatitis C in children with ALL

Genevieve LaureysH VerelstC DhoogheGeert Leroux-RoelsL Van RenterghemYves Benoit

Non-responsiveness to hepatitis B surface antigen (HBsAg) in vaccine recipients

Geert Leroux-RoelsIsabelle DesombereEric Van HeckeP VOETP HAUSER

Plasma urokinase levels in cardiovascular diseases

Jan PhilippéMarc De BuyzereDaniel DuprezA WEYNEGeert Leroux-RoelsGaston Baele

A2 Journal Article in THROMBOSIS RESEARCH

Prothrombin activation fragment 1+2, thrombin-antithrombin III complex and D-dimer determinations in peripheral arterial occlusive disease - influence of treadmill exercise.

Gaston BaeleDaniel DuprezMarc De BuyzereJan PhilippéDenis ClementGeert Leroux-Roels

A2 Journal Article in BRITISH JOURNAL OF HAEMATOLOGY

STIMULATION OF ERYTHROPOIETIN PRODUCTION AFTER CONTROLLED BLOOD-LOSS.

Jan PhilippéGeert Leroux-RoelsMarc De BuyzereA WEYNE

A1 Journal Article in EUROPEAN JOURNAL OF HAEMATOLOGY

The prognostic value of serum lactate dehydrogenase in children with acute lymphoblastic leukemia (ALL)

D BullensYves BenoitG LaureysK DhoogeJean PlumGeert Leroux-RoelsJuliaan Leroy

The relationship between TNF-a and liver failure

Jan PhilippéFritz OffnerGeert Leroux-Roels

A2 Journal Article in Eur. Cytokine Netw., 3, p. 253

1991

Basal fibrinolysis in essential-hypertension and peripheral arterial disease

Marc De BuyzereJ PhilippeDaniel DuprezG BaeleDenis ClementGeert Leroux-Roels

Can creatine predict further major cardiovascular events after acute myocardial infarction ?

J DELANGHEMarc De BuyzereGeert Leroux-RoelsDenis Clement

A2 Journal Article in Ann. Clin. Biochem., 28

Elimination of glucose interference in the enzymatic determination of inulin.

Joris DelangheJ BELLONMarc De BuyzereG VAN DAELEGeert Leroux-Roels

A2 Journal Article in Clin. Chem.

Evaluation of the automated haematology analyser Sysmex NE-8000

Katrien DevreeseErik De LogiChristiane FrancartB HeyndrickxJan PhilippéGeert Leroux-Roels

A1 Journal Article in EUROPEAN JOURNAL OF CLINICAL CHEMISTRY AND CLINICAL BIOCHEMISTRY

Fibrinolysis and coagulation in patients with infectious disease and sepsis

Jan PhilippéFritz OffnerPJ De ClerckGeert Leroux-RoelsDirk VogelaersGaston BaeleD Collen

A1 Journal Article in THROMBOSIS AND HAEMOSTASIS

Fibrinolytic and coagulant profile in severe infection and sepsis

Jan PhilippéGeert Leroux-Roels

Haptoglobin 2-2, a genetic marker for therapy resistance in established essential hypertension

Joris DelangheDaniel DuprezMarc De BuyzereB CallensGeert Leroux-RoelsDenis Clement

Het pre-operatief laboratoriumonderzoek bij kleine ingrepen

Joris DelangheGeert Leroux-Roels

A4 Journal Article in FOLIA DIAGNOSTICA

Low serum creatine kinase in patients with infective endocarditis

I De ScheerderJ DelangheMarc De BuyzereG HollandersDenis ClementGeert Leroux-Roels

A1 Journal Article in CLINICA CHIMICA ACTA

Serum TNF levels in patients with infectious disease and septic shock

Fritz OffnerJan PhilippéDirk VogelaersGaston BaeleFrancis ColardynM BaudrihayeAlex VermeulenGeert Leroux-Roels

Bookchapter in The year book of surgery 1991

1990

In-vitro production of cytokines in blood

Geert Leroux-RoelsJan PhilippéFritz OffnerAlex Vermeulen

A1 Journal Article in LANCET

Serum tumor necrosis factor levels in patients with infectious disease and septic shock

Fritz OffnerJan PhilippéDirk VogelaersFrancis ColardynGaston BaeleM BaudrihayeAlex VermeulenGeert Leroux-Roels

A1 Journal Article in JOURNAL OF LABORATORY AND CLINICAL MEDICINE

1988

Influence of blood-collecting systems on concentrations of tumor necrosis factor in serum and plasma

Geert Leroux-RoelsFritz OffnerJan PhilippéAlex Vermeulen

A1 Journal Article in CLINICAL CHEMISTRY

1987

Specific suppression elicited by EL4 lymphoma cells in syngeneic mice : specificity includes self-antigens on EL4

Johan GrootenGeert Leroux-RoelsWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

1986

Genetische manipulatie in de toekomst

Geert Leroux-RoelsWalther Fiers

A4 Journal Article in ANNALES COLLEGII MEDICI ANTVERPIENSIS

In vivo anti-tumour activity of recombinant human and murine TNF, alone and in combination with murine IFN-γ, on a syngeneic murine melanoma

Peter BrouckaertGeert Leroux-RoelsYves GuisezJan TavernierWalther Fiers

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

Acute verwikkelingen van vaccinaties. Vax Info 20,1998 3-4.

Geert Leroux-Roels

Cytotoxic T lymphocytes in HBV and HCV infections: beneficial or harmful ? Central-EurJ Immunol 1997,22: 155-157.

Geert Leroux-RoelsIsabelle DesombereStany DepraetereC TINGHUA

Hepatitis A en B - Gecombineerd vaccin. Vax Info 1997, 19: 1-2.

Geert Leroux-RoelsP TREFOIS

Hepatitis B virus (HBV)-specific CTL responses in patients with acute and chronic HBV infections. Proc. of the 8th Triennial Congress: 1993 International Symposium on Viral Hepatitis and Liver Disease. Tokyo, May 10-14, 1993, p. 164.

Eric Van HeckeC MOLITORC BASTINP PALAM SLAOUIGeert Leroux-Roels

Immunogenicity of a new hepatitis B vaccine containing preSl and preS2 epitopes. Proc. of the 8th Triennial Congress: 1993 International Sympo sium on Viral Hepatitis and Liver Disease. Tokyo, May 10-14, 1993, p. 164.

Geert Leroux-RoelsIsabelle DesombereP HAUSERPatrick DegraveJ PETREP VANDEPAPELIEREA SAFARY

Non-responsiveness to hepatitis B surface antigen (HBsAg) in vaccine recipients. Falk Symposium nr. 70, Immunology and Liver, oct. 18-20, 1992.

Geert Leroux-RoelsIsabelle DesombereEric Van HeckeP VOETP HAUSER

Onderzoek naar een aantal prognostische markers bij patiënten met zeer ernstige infectie of sepsis. 8e Amstol Symposium, Amsterdam, 25/9/1992, werkboek p. 3.4.

Jan PhilippéG DOOUEWAARDFritz OffnerP TURIONGaston BaeleGeert Leroux-Roels

Risico op overdracht van infecties bij geassisteerde fertilisatie: een overzicht. Tijdschrift voor Fertiliteitsonderzoek - FTO; 12, 1998, 82-87.

Sophia SteyaertGeert Leroux-Roels

A3 Journal Article

Vaccins in vraag en antwoord. Medisch-Informatieve Reeks nr. 10. Garant, Leuven/Apeldoorn. Tweede, herziene en vermeerderde editie: 1998.

Geert Leroux-Roels

Waarom geeft men als basisschema bij de zuigelingen 3 dosissen (0, 1 en 6 maanden) ? Vax Info 21: 8, 1998.

P VAN DAMMEGeert Leroux-Roels