Research Explorer

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Researcher

Fritz Offner

309 Results

2022

A unique phenotype of longitudinal extensive transverse myelitis in autoimmune lymphoproliferative syndrome

Cathérine DekeyserLeslie NaesensFritz OffnerCiel De VriendtAlexander SchauwvliegheTessa KerreGuy Laureys

A1 Journal Article in JOURNAL OF NEUROIMMUNOLOGY

Carfilzomib maintenance in newly diagnosed non-transplant eligible multiple myeloma

Arthur BobinMaeva KyhengStephanie GuidezCecile Gruchet-MerouzeValentine RichezAlain DuhamelLionel KarlinBrigitte KolbMourad TiabCarla AraujoNathalie MeulemanJean-Valere MalfusonPascal BourquardPascal LenainAurore PerrotMurielle RousselArnaud JaccardMarie-Odile PetillonKarim Belhadj-MerzougMarie-Lorraine ChretienJean FontanPhilippe RodonAnna SchmittFritz OffnerLaurent VoillatSophie CerejaFrederique KuhnowskiSophie RigaudeauOlivier DecauxCatherine Humbrecht-KrautJamile FrayferOlivier FitoussiDamien Roos-WeilJean Claude EisenmannVeronique DorvauxEric G. VoogPhilippe MoreauHerve Avet-LoiseauCyrille HulinThierry FaconXavier Leleu

A1 Journal Article in LEUKEMIA

Comparison of the effectiveness and safety of the oral selective inhibitor of nuclear export, selinexor, in diffuse large B cell lymphoma subtypes

Rene-Olivier CasasnovasGeorge FollowsJosee M. ZijlstraJoost S. P. VermaatNagesh KalakondaSylvain ChoquetEric Van den NesteBrian HillCatherine ThieblemontFederica CavalloFatima De la CruzJohn KuruvillaNada HamadUlrich JaegerPaolo F. CaimiRonit GurionKrzysztof WarzochaSameer BakhshiJuan-Manuel SanchoMichael SchusterMiklos EgyedFritz OffnerTheodoros P. VassilakopoulosPriyanka SamalMatthew KuXiwen MaKamal ChamounJatin ShahMiguel CanalesMarie MaerevoetSharon ShachamMichael G. KauffmanAndre Goy

A1 Journal Article in CLINICAL LYMPHOMA MYELOMA & LEUKEMIA

Cusatuzumab for treatment of CD70-positive relapsed or refractory cutaneous T-cell lymphoma

Nicolas LeupinPier Luigi ZinzaniFranck MorschhauserStephane DalleMarie MaerevoetJean-Marie MichotVincent RibragFritz OffnerMarie Beylot-BarryHelene Moins-TeisserencKaren ZwaenepoelKoen de WinneMaxime BattistellaAnna HultbergDomenica GandiniMahan MoshirJulie JacobsTim DelahayeAitzaz KhanPiotr ZabrockiKaren SilenceLuc van RompaeyChristophe BorgGiovanna MottaFederica MelleAngelica CalleriPatrick PauwelsHans de HaardStefano PileriMartine Bagot

A1 Journal Article in CANCER

Identifying patients with chronic lymphocytic leukemia without need of treatment : end of endless watch and wait?

Christian BrieghelVeerle GalleRudi AgiusCaspar Da Cunha-BangMichael A. AndersenPhilip VlummensMattias MattssonRichard RosenquistKarin E. SmedbyCarmen D. HerlingJasmin BahloMichael HallekJens D. LundgrenFritz OffnerCarsten U. Niemann

A1 Journal Article in EUROPEAN JOURNAL OF HAEMATOLOGY

Nucleic acid biomarkers in Waldenstrom Macroglobulinemia and IgM-MGUS : current insights and clinical relevance

Daniela DrandiPhilippe DecruyenaereMartina FerranteFritz OffnerJo VandesompeleSimone Ferrero

A1 Journal Article in DIAGNOSTICS

Prolonged remissions after nivolumab plus gemcitabine/oxaliplatin in relapsed/refractory T-cell lymphoma

Roch HouotViola PoeschelBettina AltmannStephanie AngelLorenz ThurnerThomas IllmerMarc AndreMartin DreylingHerve MaisonneuveHerve TillyStephanie MayerOlivier CasasnovasSteven Le GouillFritz OffnerGuillaume CartronAndrea KerkhoffThomas WeberJoerg HoffmannMarita ZiepertWolfram KlapperEmmanuel IttiDirk HellwigGiorgi NatchkebiaLaurence de LevalAndreas RosenwaldCorinne HaiounLaurent DerclePhilippe GaulardGerhard Held

A1 Journal Article in HEMASPHERE

Real-world estimation of first- and second-line treatments for diffuse large B-cell lymphoma using health insurance data : a Belgian population-based study

Willem DaneelsMichael RosskampGilles MacqEstabraq Ismael SaadoonAnke De GeyndtFritz OffnerHélène A. Poirel

A1 Journal Article in FRONTIERS IN ONCOLOGY

Shallow-depth sequencing of cell-free DNA for Hodgkin and diffuse large B-cell lymphoma (differential) diagnosis : a standardized approach with underappreciated potential

Lennart RamanMalaïka Van der LindenCiel De VriendtBliede Van den BroeckKristoff MuylleDries DeerenFranceska DedeurwaerdereSofie VerbekeAmélie DendoovenKatrien De GroveSaskia BaertKathleen ClaesBjörn MentenFritz OffnerJo Van Dorpe

A1 Journal Article in HAEMATOLOGICA

Shallow-depth sequencing of cell-free DNA for Hodgkin and diffuse large B-cell lymphoma (differential) diagnosis: a standardized approach with underappreciated potential

Lennart RamanMalaïka Van Der LindenCiel De VriendtBliede Van den BroeckKristoff MuylleDries DeerenFranceska DedeurwaerdereSofie VerbekeAmélie DendoovenKatrien De GroveSaskia BaertKathleen ClaesBjörn MentenFritz OffnerJo Van Dorpe

U Journal Article in Haematologica

Systemic mastocytosis with myeloid sarcoma and B-CLL : molecular and clonal heterogeneity in a rare case of SM-AHN with review of literature

Philippe DecruyenaereDominiek MazureIne MoorsJo Van DorpeMalaïka Van der LindenBarbara DenysMattias HofmansFritz Offner

A1 Journal Article in ACTA CLINICA BELGICA

The association between patient characteristics and the efficacy and safety of selinexor in diffuse large B-cell lymphoma in the SADAL study

Josee M. ZijlstraGeorge FollowsRene-Olivier CasasnovasJoost S. P. VermaatNagesh KalakondaSylvain ChoquetBrian HillCatherine ThieblemontFederica CavalloFatima De la CruzJohn KuruvillaNada HamadUlrich JaegerPaolo CaimiRonit GurionKrzysztof WarzochaSameer BakhshiJuan-Manuel SanchoMichael SchusterMiklos EgyedFritz OffnerTheodoros P. VassilakopoulosPriyanka SamalMatthew KuJenny XuKelly CoronaKamal ChamounJatin ShahMiguel CanalesMarie Maerevoet

A1 Journal Article in CANCERS

Tisagenlecleucel in adult relapsed or refractory follicular lymphoma : the phase 2 ELARA trial

Nathan Hale FowlerMichael DickinsonMartin DreylingJoaquin Martinez-LopezArne KolstadJason ButlerMonalisa GhoshLeslie PopplewellJulio C. ChavezEmmanuel BachyKoji KatoHideo HarigaeMarie Jose KerstenCharalambos AndreadisPeter A. RiedellP. Joy HoJose Antonio Perez-SimonI Chen, AndyLoretta J. NastoupilBastian von TresckowAndres Jose Maria FerreriTakanori TeshimaPiers E. M. PattenJoseph P. McGuirkAndreas L. PetzerFritz OffnerAndreas ViardotPier Luigi ZinzaniRam MalladiAiesha ZiaRakesh AwasthiAisha MasoodOezlem AnakStephen J. SchusterCatherine Thieblemont

A1 Journal Article in NATURE MEDICINE

2021

Avelumab in combination regimens for relapsed/refractory DLBCL : results from the phase Ib JAVELIN DLBCL study

Eliza A. HawkesTycel PhillipsLihua Elizabeth BuddeArmando SantoroNakhle S. SabaFernando RoncolatoGareth P. GregoryGregor VerhoefFritz OffnerCristina QueroJohn RadfordKrzysztof GiannopoulosDon StevensAron ThallBo HuangA. Douglas LairdRobin SandnerStephen M. Ansell

A1 Journal Article in TARGETED ONCOLOGY

Circulating RNA biomarkers in diffuse large B-cell lymphoma : a systematic review

Philippe DecruyenaereFritz OffnerJo Vandesompele

A1 Journal Article in EXPERIMENTAL HEMATOLOGY & ONCOLOGY

Covalent cysteine targeting of Bruton's tyrosine kinase (BTK) family by withaferin-A reduces survival of glucocorticoid-resistant multiple myeloma MM1 cells

Emilie LogieChandra S. ChirumamillaClaudina Perez-NovoPriyanka ShawKen DeclerckAjay PalaganiSavithri RangarajanBart CuypersNicolas De NeuterFazil Mobashar Hussain Urf TurabeNavin Kumar VermaAnnemie BogaertsKris LaukensFritz OffnerPieter Van VlierbergheXaveer Van OstadeWim Vanden Berghe

A1 Journal Article in CANCERS

Cyclin D2 overexpression drives B1a-derived MCL-like lymphoma in mice

Tim PietersSara T'SasStijn VanheeAndré Pedro Pinto De AlmeidaYasmine DriegeJuliette RoelsWouter Van LoockeWillem DaneelsMathijs BaensArnaud MarchandMaaike Van TrimpontFilip MatthijssensJulie MorscioKelly LemeireBéatrice LintermansLindy ReunesPatrick ChaltinFritz OffnerJo Van DorpeTino HochepiedGeert BerxRudi BeyaertJens StaalPieter Van VlierbergheSteven Goossens

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Glofitamab step-up dosing (SUD) : updated efficacy data show high complete response rates in heavily pretreated relapsed/refractory (R/R) non-Hodgkin lymphoma (NHL) patients (Pts)

Carmelo Carlo-StellaCyrus KhanMartin HutchingsFritz OffnerFranck MorschhauserEmmanuel BachyMichael CrumpAnna SuredaGloria IacoboniCorinne HaiounDavid Perez-CallejoLinda LundbergJames RelfEmma ClarkDavid CarlileEmily PiccioneAnton BelousovKathryn HumphreyMichael J. Dickinson

Glofitamab, a novel, bivalent CD20-targeting T-cell-engaging bispecific antibody, induces durable complete remissions in relapsed or refractory B-cell lymphoma : a phase I trial

Martin HutchingsFranck MorschhauserGloria IacoboniCarmelo Carlo-StellaFritz OffnerAnna SuredaGilles SallesJoaquin Martinez-LopezMichael CrumpDenise N. ThomasPeter N. MorcosCristiano FerliniAnn-Marie E. BroeskeAnton BelousovMarina BacacNatalie DimierDavid J. CarlileLinda LundbergDavid Perez-CallejoPablo UmanaTom MooreMartin WeisserMichael J. Dickinson

A1 Journal Article in JOURNAL OF CLINICAL ONCOLOGY

Health-related quality of life and utility outcomes with selinexor in relapsed/refractory diffuse large B-cell lymphoma

Jatin ShahSharon ShachamMichael KauffmanPatrick DanieleDimitrios TomarasGabriel TremblayRene-Olivier CasasnovasMarie MaerevoetJosee ZijlstraGeorge FollowsJoost S. P. VermaatNagesh KalakondaAndre Henri GoySylvain ChoquetEric Van den NesteBrian T. HillCatherine ThieblemontFederica CavalloFatima de la CruzJohn KuruvillaNada HamadReda BouabdallahUlrich JagerPaolo CaimiRonit GurionKrzysztof WarzochaSameer BakhshiJuan Manuel SanchoMichael SchusterMiklos EgyedFritz OffnerTheodoros P. VasilakopoulosPriyanka SamalAgnes NagyMatthew KuMiguel Angel Canales Albendea

A1 Journal Article in FUTURE ONCOLOGY

Long-term follow-up, up to 7 years, in the RESONATE-2 study of first-line ibrutinib treatment for chronic lymphocytic leukemia (CLL)

Jan BurgerPaul BarrCarolyn OwenTadeusz RobakAlessandra TedeschiOsnat BaireyPeter HillmenSteve CoutreStephen DevereuxSebastian GrosickiHelen McCarthyJianyong LiFritz OffnerCarol MorenoSandra DaiAnita SzokeJames P. DeanThomas J. KippsPaolo Ghia

Maintenance with daratumumab or observation following treatment with bortezomib, thalidomide, and dexamethasone with or without daratumumab and autologous stem-cell transplant in patients with newly diagnosed multiple myeloma (CASSIOPEIA) : an open-label, randomised, phase 3 trial

Philippe MoreauCyrille HulinAurore PerrotBertrand ArnulfKarim BelhadjLotfi BenboubkerMarie C. BeneSonja ZweegmanHelene CaillonDenis CaillotJill CorreMichel DelforgeThomas DejoieChantal DoyenThierry FaconCecile SonntagJean FontanMohamad MohtyKon-Siong JieLionel KarlinFrederique KuhnowskiJerome LambertXavier LeleuMargaret MacroFrederique Orsini-PiocelleMurielle RousselAnne-Marie StoppaNiels W. C. J. van de DonkSoraya WuillemeAnnemiek BroijlCyrille TouzeauMourad TiabJean-Pierre MarolleauNathalie MeulemanMarie-Christiane VekemansMatthijs WestermanSaskia K. KleinMark-David LevinFritz OffnerMartine Escoffre-BarbeJean-Richard EveillardReda GaridiTahamtan AhmadiMaria KrevvataKe ZhangCarla de BoerSanjay VaraTobias KampfenkelVeronique VanquickelbergheJessica VermeulenHerve Avet-LoiseauPieter Sonneveld

A1 Journal Article in LANCET ONCOLOGY

Nivolumab in combination with Gemcitabine and Oxaliplatin (GemOx) in Relapse/Refractory T-cell Lymphoma: Preliminary results of the experimental arm of the NIVEAU trial

G. HeldV PoeschelB. AltmannT. IllmerM. AndreM. DreylingH. MaisonneuveH. TillyS. MayerR. -O CasasnovasS. Le GouillFritz OffnerG. CartronA. KerkhoffT. WeberJ. HoffmannM. ZiepertW. KlapperE. IttiD. HellwigG. NatchkebiaL. De LevalA. RosenwaldC. HaiounL. DercleP. GaulardR. Houot

Oral ixazomib, lenalidomide, and dexamethasone for transplant-ineligible patients with newly diagnosed multiple myeloma

Thierry FaconChristopher P. VennerNizar J. BahlisFritz OffnerDarrell J. WhiteLionel KarlinLotfi BenboubkerSophie RigaudeauPhilippe RodonEric VoogSung-Soo YoonKenshi SuzukiHirohiko ShibayamaXiaoquan ZhangPhilip Twumasi-AnkrahGodwin YungRobert M. RifkinPhilippe MoreauSagar LonialShaji K. KumarPaul G. RichardsonS. Vincent Rajkumar

A1 Journal Article in BLOOD

Real world application of R‐chop for diffuse large B‐cell lymphoma (DLBCL) in Belgium and its impact on survival

Willem DaneelsM. RosskampG. MacqEstabraq Ismael SaadoonA. DegeyndtFritz OffnerH. Antoine‐Poirel

Stem cell yield and transplantation in transplant-eligible newly diagnosed multiple myeloma patients receiving daratumumab plus bortezomib/thalidomide/dexamethasone in the phase III CASSIOPEIA study

Cyrille HulinFritz OffnerPhilippe MoreauMurielle RousselKarim BelhadjLotfi BenboubkerDenis CaillotThierry FaconLaurent GarderetFrederique KuhnowskiAnne-Marie StoppaBrigitte KolbMourad TiabKon-Siong JieMatthijs WestermanJerome LambertLixia PeiVeronique VanquickelbergheCarla de BoerJessica VermeulenTobias KampfenkelPieter SonneveldNiels W. C. J. van de Donk

A1 Journal Article in HAEMATOLOGICA

Survival among patients with relapsed/refractory diffuse large B cell lymphoma treated with single-agent selinexor in the SADAL study

Marie MaerevoetJosee M. ZijlstraGeorge FollowsRene-Olivier CasasnovasJ. S. P. VermaatNagesh KalakondaAndre GoySylvain ChoquetEric Van den NesteBrian HillCatherine ThieblemontFederica CavalloFatima De la CruzJohn KuruvillaNada HamadUlrich JaegerPaolo CaimiRonit GurionKrzysztof WarzochaSameer BakhshiJuan-Manuel SanchoMichael SchusterMiklos EgyedFritz OffnerTheodoros P. VassilakopoulosPriyanka SamalMatthew KuXiwen MaKelly CoronaKamal ChamounJatin ShahSharon ShachamMichael G. KauffmanMiguel Canales

A1 Journal Article in JOURNAL OF HEMATOLOGY & ONCOLOGY

Up to seven years of follow-up in the RESONATE-2 study of first-line ibrutinib treatment for patients with chronic lymphocytic leukemia

Paul M. BarrCarolyn OwenTadeusz RobakAlessandra TedeschiOsnat BaireyJan Andreas BurgerPeter HillmenSteve E. CoutreStephen DevereuxSebastian GrosickiHelen McCarthyJianyong LiDavid SimpsonFritz OffnerCarol MorenoSandra DaiAnita SzokeJames P. DeanThomas J. KippsPaolo Ghia

When hematochezia becomes a red herring

Sander SmeetsF. DedeurwaerdereE. ThomaereB. HouthoofdL. D'HulstP. WilmesFritz OffnerS. De Coninck

Editorial material

2020

A five-year follow-up of untreated patients with chronic lymphocytic leukaemia treated with ofatumumab and chlorambucil : final analysis of the Complement 1 phase 3 trial

Fritz OffnerTadeusz RobakAnn JanssensK. Govind BabuJanusz KloczkoSebastian GrosickiJiri MayerPanagiotis PanagiotidisAnna SchuhAndrew PettittMarco MontilloOlena WernerGhislaine VincentSadhvi KhannaPeter Hillmen

A1 Journal Article in BRITISH JOURNAL OF HAEMATOLOGY

Effect of age on the efficacy and safety of single agent oral selinexor in patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL) : a post-hoc analysis of the sadal pivotal study

Michael W. SchusterMiguel A. CanalesJason WestinJosee M. ZijlstraGeorge A. FollowsReem KarmaliNagesh KalakondaAndre H. GoyRene-Olivier CasasnovasJoost VermaatEric Van den NesteSylvain ChoquetCatherine ThieblemontFederica CavalloMaria de Fatima De La CruzBrian T. HillHerve TillyShireen KassamReda BouabdallahUlrich JaegerRonit GurionPaolo CaimiPeter MartinAndrew DaviesSonali M. SmithGraham P. CollinsFritz OffnerGilles SallesXiwen MaKelly CoronaJean-Richard Saint-MartinAnita A. JoshiKamal ChamounHongwei WangJatin J. ShahSharon ShachamMichael G. KauffmanMarie Maerevoet

Efficacy and safety of tisagenlecleucel in adult patients with relapsed/refractory follicular lymphoma : interim analysis of the phase 2 ELARA trial

Nathan H. FowlerMichael DickinsonMartin DreylingJoaquin Martinez-LopezArne KolstadJason P. ButlerMonalisa GhoshLeslie L. PopplewellJulio C. ChavezEmmanuel BachyKoji KatoHideo HarigaeMarie Jose KerstenCharalambos AndreadisPeter A. RiedellJoy HoJose Antonio Perez-SimonSarah J. NagleLoretta J. NastoupilBastian von TresckowAndres J. M. FerreriTakanori TeshimaPiers PattenJoseph P. McGuirkAndreas PetzerFritz OffnerAndreas ViardotPier Luigi ZinzaniRam MalladiLida Bubuteishvili PacaudAlessandra ForcinaAiesha ZiaStephen J. SchusterCatherine Thieblemont

Glofitamab in relapsed or refractory (R/R) non-Hodgkin lymphoma (NHL) : durable complete responses and manageable safety observed at clinically relevant doses in Phase I dose escalation

M. HutchingsF. MorschhauserG. IacoboniC. Carlo-StellaFritz OffnerA. SuredaG. SallesJ. Martinez-LopezM. CrumpL. LundbergM. DixonA. KwanM. C. WeiA-M E. BroeskeD. CarlileC. O'HearM. J. Dickinson

Health utility in relapsed/refractory diffuse large B-cell lymphoma (RR-DLBCL) patients : results of a phase II trial with oral selinexor

R. O. CasasnovasP. DanieleG. TremblayM. MaerevoetJ. ZijlstraG. FollowsJ. S. P. VermaatN. KalakondaA. H. GoyS. ChoquetE. Van den NesteB. T. HillC. ThieblemontF. CavalloF. de la CruzJ. KuruvillaN. HamadR. BouabdallahU. JaegerP. CaimiR. GurionK. WarzochaS. BakhshiJ. M. SanchoM. SchusterM. EgyedFritz OffnerT. VasilakopoulosP. SamalA. NagyM. KuM. A. Canales Albendea

Ibrutinib for first-line treatment of chronic lymphocytic leukemia in patients aged >= 65 year of age : results with 5 years of follow-up for the RESONATE-2 study

Alessandra TedeschiJan A. BurgerPaul BarrTadeusz RobakCarolyn OwenPaolo GhiaOsnat BaireyPeter HillmenSteven CoutreStephen DevereuxSebastian GrosickiHelen McCarthyJianyong LiDavid SimpsonFritz OffnerCarol MorenoXiaoxian DaiIndu LalJames DeanThomas J. Kipps

Ixazomib plus lenalidomide-dexamethasone (IRd) vs. placebo-Rd for newly diagnosed multiple myeloma (NDMM) patients not eligible for autologous stem cell transplant : the double-blind, placebo-controlled, phase 3 TOURMALINE-MM2 trial

Thierry FaconChristopher P. VennerNizar J. BahlisMichel AttalFritz OffnerDarrell J. WhiteLionel KarlinLotfi BenboubkerSophie RigaudeauPhilippe RodonEric VoogSung-Soo YoonKenshi SuzukiHirohiko ShibayamaXiaoquan ZhangGodwin YungRobert M. RifkinPhilippe MoreauSagar LonialShaji K. KumarPaul G. RichardsonS. Vincent Rajkumar

Latest perspectives on glucocorticoid-induced apoptosis and resistance in lymphoid malignancies

Dorien ClarisseFritz OffnerKarolien De Bosscher

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Long-term efficacy and safety of first-line ibrutinib treatment for patients with CLL/SLL : 5 years of follow-up from the phase 3 RESONATE-2 study

Jan A. BurgerPaul M. BarrTadeusz RobakCarolyn OwenPaolo GhiaAlessandra TedeschiOsnat BaireyPeter HillmenSteven E. CoutreStephen DevereuxSebastian GrosickiHelen McCarthyDavid SimpsonFritz OffnerCarol MorenoSandra DaiIndu LalJames P. DeanThomas J. Kipps

A1 Journal Article in LEUKEMIA

Nivolumab in combination with gemcitabine and oxaliplatin (GemOx) in relapse/refractory T-cell lymphoma : preliminary results of the experimental arm of the niveau trial

Roch HouotViola PoeschelBettina AltmannThomas IllmerMarc AndreMartin DreylingHerve MaisonneuveHerve TillyStephanie MayerRene-Olivier CasasnovasSteven Le GouillFritz OffnerGuillaume CartronAndrea KerkhoffThomas WeberJoerg HoffmannMarita ZiepertWolfram KlapperEmmanuel IttiDirk HellwigLaurence De LevalAndreas RosenwaldCorinne HaiounPhilippe GaulardGerhard Held

Phase 1 study of CD19 targeted 4-1BBL costimulatory agonist to enhance T cell (glofitamab combination) or NK cell effector function (obinutuzumab combination) in relapsed/refractory B cell lymphoma

Martin HutchingsFritz OffnerFrancesc BoschGiuseppe GrittiCarmelo Carlo-StellaHarriet WalterWilliam TownsendFranck MorschhauserGuillaume CartronHerve GhesquieresSophie de GuibertSylvia HerterKoorosh KorfiVeronica CraineSarah Louise MycroftMatt WhaymanClaudia MuellerNatalie DimierTom MooreSara BelliMartin KornackerKatharina LechnerMichael Dickinson

Prognostic and predictive role of gene mutations in chronic lymphocytic leukemia : results from the pivotal phase III study COMPLEMENT1

Eugen TauschPhilipp BeckRichard F. SchlenkBilly M. C. JebarajAnna DolnikDeyan Y. YosifovPeter HillmenFritz OffnerAnn JanssensK. Govind BabuSebastian GrosickiJiri MayerPanagiotis PanagiotidisAstrid McKeownIra V. GuptaAlexandra SkorupaCeline PallaudLars BullingerDaniel MertensHartmut DoehnerStephan Stilgenbauer

A1 Journal Article in HAEMATOLOGICA

Real world population-based exploration of the pathology subtyping and treatment-modalities of diffuse large B-cell lymphoma in Belgium in relation to survival

Willem DaneelsMichael RosskampGilles MacqEstabraq Ismael SaadoonAnke De GeyndtFritz OffnerHélène Antoine-Poirel

Real world population-based exploration of the pathology subtyping and treatment-modalities of diffuse large B-cell lymphoma in Belgium in relation to survival

Willem DaneelsMichael RosskampGilles MacqEstabraq Ismael SaadoonTim De GeyndtFritz OffnerHélène Antoine-Poirel

Selinexor efficacy and safety are independent of renal function in patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL) : a post-hoc analysis from the pivotal phase 2b sadal study

Michael W. SchusterMiguel A. CanalesJason WestinJosee M. ZijlstraGeorge A. FollowsReem KarmaliNagesh KalakondaAndre H. GoyRene-Olivier CasasnovasJoost VermaatEric Van den NesteSylvain ChoquetCatherine ThieblemontFederica CavalloMaria de Fatima De La CruzBrian T. HillHerve TillyShireen KassamReda BouabdallahUlrich JaegerRonit GurionPaolo CaimiPeter MartinAndrew DaviesSonali M. SmithGraham P. CollinsFritz OffnerGilles SallesXiwen MaKelly CoronaJean-Richard Saint-MartinAnita A. JoshiKamal ChamounHongwei WangJatin J. ShahSharon ShachamMichael G. KauffmanMarie Maerevoet

Selinexor in patients with relapsed or refractory diffuse large B-cell lymphoma (SADAL) : a single-arm, multinational, multicentre, open-label, phase 2 trial

Nagesh KalakondaMarie MaerevoetFederica CavalloGeorge FollowsAndre GoyJoost S. P. VermaatOlivier CasasnovasNada HamadJosee M. ZijlstraSameer BakhshiReda BouabdallahSylvain ChoquetRonit GurionBrian HillUlrich JaegerJuan Manuel SanchoMichael SchusterCatherine ThieblemontFatima De la CruzMiklos EgyedSourav MishraFritz OffnerTheodoros P. VassilakopoulosKrzysztof WarzochaDaniel McCarthyXiwen MaKelly CoronaJean-Richard Saint-MartinHua ChangYosef LandesmanAnita JoshiHongwei WangJatin ShahSharon ShachamMichael KauffmanEric Van den NesteMiguel A. Canales

A1 Journal Article in LANCET HAEMATOLOGY

Shallow whole-genome sequencing of cell-free DNA for B-cell lymphoma diagnosis and disease monitoring : a standardized approach with underappreciated potential

Malaïka Van der LindenLennart RamanCiel De VriendtBliede Van den BroeckKristoff MuylleDries DeerenKathleen ClaesBjörn MentenFritz OffnerJo Van Dorpe

Shallow whole-genome sequencing of cell-free DNA for B-cell lymphoma diagnosis and disease monitoring: a standardized approach with underappreciated potential

Malaïka Van der LindenLennart RamanCiel De VriendtBliede Van den BroeckKristoff MuylleDries DeerenKathleen ClaesBjörn MentenFritz OffnerJo Van Dorpe

2019

A phase 2b study of selinexor in patients with Relapsed/Refractory (R/R) Diffuse Large B-Cell Lymphoma (DLBCL)

Nagesh KalakondaFederica CavalloGeorge FollowsAndre GoyJoost S. P. VermaatOlivier CasasnovasOrly LaveeMarie MaerevoetJosee ZijlstraSameer BakhshiReda BouabdallahSylvain ChoquetRonit GurionBrian HillUlrich JaegerJuan-Manuel SanchoMichael SchusterCatherine ThieblemontFatima De la CruzMiklos EgyedSourav MishraFritz OffnerTheodoros VassilakopoulosKrzysztof WarzochaDaniel McCarthyXiwen MaKelly CoronaJean-Richard Saint-MartinAnita JoshiJatin ShahEric Van den NesteMiguel Canales

AUGMENT : a phase III study of lenalidomide plus rituximab versus placebo plus rituximab in relapsed or refractory indolent lymphoma

John P LeonardMarek TrnenyKoji IzutsuNathan H FowlerXiaonan HongJun ZhuHuilai ZhangFritz OffnerAdriana ScheligaGrzegorz S NowakowskiAntonio PintoFrancesca ReLaura Maria FogliattoPhillip ScheinbergIan W FlinnClaudia MoreiraJose CabecadasDavid LiuStacey KalambakasPierre FustierChengqing WuJohn G GribbenMaria CalaminiciChristiane Copie-BergmanArmando Lopez-GuillermoOwen O'ConnorMichael WilliamsStefan SuciuBenjamin LevineJulie Kern

A1 Journal Article in JOURNAL OF CLINICAL ONCOLOGY

Carfilzomib weekly plus melphalan and prednisone in newly diagnosed transplant-ineligible multiple myeloma (IFM 2012-03) : a phase I trial

Xavier LeleuGuillemette FouquetValentine RichezStephanie GuidezAlain DuhamelFrancois MachuronLionel KarlinBrigitte KolbMourad TiabCarla AraujoNathalie MeulemanJean-Valere MalfusonPascal BourquardPascal LenainMurielle RousselArnaud JaccardMarie-Odile PetillonKarim Belhadj-MerzougGerard LepeuMarie-Lorraine ChretienJean FontanPhilippe RodonAnna SchmittFritz OffnerLaurent VoillatSophie CerejaFrederique KuhnowskiSophie RigaudeauOlivier DecauxCatherine Humbrecht-KrautJamile FrayferOlivier FitoussiDamien Roos-WeilJean-Claude EisenmannVeronique DorvauxEric G VoogMichel AttalPhilippe MoreauHerve Avet-LoiseauCyrille HulinThierry Facon

A1 Journal Article in CLINICAL CANCER RESEARCH

Characterization of duvelisib in patients with refractory marginal zone lymphoma : data from the phase 2 DYNAMO trial

Eric JacobsenJuraj UraKirit ArdeshnaMohamad CherryFritz OffnerJiri MayerFontanet BijouMonica TaniGerardo MusuracaMichele MerliRoberto MarascaDavid T WeaverStephanie LustgartenHagop YoussoufianPier Luigi Zinzani

Characterization of duvelisib in patients with refractory marginal zone lymphoma : data from the phase 2 DYNAMO trial

Eric JacobsenJuraj DurasKirit ArdeshnaMohamad CherryFritz OffnerJiri MayerFontanet BijouMonica TaniGerardo MusuracaMichele MerliRoberto MarascaDavid WeaverStephanie LustgartenHagop YoussoufianPier Luigi Zinzani

Dual CD20-targeted therapy with concurrent CD20-TCB and obinutuzumab shows highly promising clinical activity and manageable safety in relapsed or refractory B-cell non-Hodgkin lymphoma : preliminary results from a phase Ib trial

Franck MorschhauserCarmelo Carlo-StellaFritz OffnerGilles A. SallesMartin HutchingsGloria IacoboniAnna SuredaMichael CrumpJoaquin Martinez-LopezDenise ThomasPeter N. MorcosCristiano FerliniAbiraj KeelaraAnn-Marie E. BroeskeMarina BacacNatalie DimierTom MooreMartin WeisserMichael Dickinson

Effect of dose modifications on response to duvelisib in patients with Relapsed/Refractory (R/R) CLL/SLL in the DUO trial

Ian FlinnMarco MontilloArpad IllesGabriel EtienneJulio DelgadoBryone KussConstantine TamFritz OffnerFrancesc BoschMatthew DavidsUlrich JaegerPaolo GhiaFlorence CymbalistaDavid WeaverStephanie LustgartenHagop YoussoufianStephan StilgenbauerNicole Lamanna

Effect of dose modifications on response to duvelisib in patients with relapsed or refractory chronic lymphocytic leukemia/small lymphocytic lymphoma in the DUO trial

Nicole LamannaMarco MontiloArpad IllesGabriel EtienneJulio DelgadoBryone J KussConstantine S TamFritz OffnerFrancesc BoschMatthew S DavidsUlrich JaegerPaolo GhiaFlorence CymalistaDavid T WeaverStephanie LustgartenHagop YoussoufianStephan StilgenbauerIan W Flinn

Effect of prior therapy on the efficacy and safety of oral Selinexor in patients with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) : a post-hoc analysis of the SADAL study

Federica CavalloGeorge A. FollowsAndre GoyJoost VermaatRene-Olivier CasasnovasOrly LaveeMarie MaerevoetJosee M. ZijlstraSameer BakhshiReda BouabdallahSylvain ChoquetRonit GurionBrian T. HillUlrich JaegerJuan-Manuel SanchoMichael W. SchusterCatherine ThieblemontFatima De la CruzMiklos EgyedSourav MishraFritz OffnerTheodoros P. VassilakopoulosKrzysztof WarzochaDaniel McCarthyXiwen MaKelly CoronaJean-Richard Saint-MartinAnita JoshiJatin ShahEric Van den NesteMiguel A. CanalesNagesh Kalakonda

Efficacy and time to next treatment following lenalidomide/rituximab (R-2) or rituximab/placebo in patients with R/R indolent NHL (AUGMENT)

John G. GribbenKoji IzutsuNathan Hale FowlerXiaonan HongHuilai ZhangFritz OffnerAdriana A. S. ScheligaGrzegorz S. NowakowskiAntonio PintoFrancesca ReLaura Maria FogliattoPhillip ScheinbergIan FlinnClaudia MoreiraStacey Anastasia KalambakasPierre FustierChengqing (Alan) WuJohn Paul Leonard

Exploring the potential of shallow whole-genome sequencing for diagnosis and disease monitoring of lymphoma in liquid biopsy

Lennart RamanMalaïka Van der LindenCiel De VriendtBliede Van den BroeckKristoff MuylleDries DeerenBjörn MentenFritz OffnerJo Van Dorpe

Five-year follow-up after ibrutinib therapy for first-line treatment of chronic lymphocytic leukemia

Jan BurgerAlessandra TedeschiPaul M. BarrTadeusz RobakCarolyn OwenPaolo GhiaOsnat BaireyPeter HillmenSteven E. CoutreStephen DevereuxSebastian GrosickiHelen McCarthyJianyong LiDavid SimpsonFritz OffnerCarol MorenoSandra DaiIndu LalJames P. DeanThomas J. Kipps

Implication of inherited genetic variants associated with follicular lymphoma susceptibility in the prognosis of patients treated by immunochemotherapy in PRIMA study

Herve GhesquieresYouenn DrouetSarah HuetGuillaume CartronMarie-Helene DelfauFritz OffnerPauline BriceLuc XerriReda BouabdallahGilles A. Salles

Ixazomib, Rituximab and Dexamethasone (IRD) in patients with relapsed or progressive Waldenstrom's macroblobulinemia : results of the prospective phase I/II hovon 124/Ecwm-R2 trial

Marie Jose KerstenMonique C. MinnemaJosephine M. VosKazem NasserinejadMarcel KapEftathios KastritisMaria GavriatopoulouMartine E. D. ChamuleauDries DeerenLidwine WinnifredJeanette K. DoorduijnFritz OffnerLara H. BohmerKarima AmaadorRoberto D. LiuSteven T. PalsMeletios A. Dimopoulos

Lenalidomide/rituximab (R2) versus rituximab/placebo efficacy by POD24 status and time to next treatment in patients with relapsed/refractory indolent NHL (AUGMENT)

A PintoJ GribbenM TrnenyK IzutsuNH FowlerX HongH ZhangFritz OffnerA ScheligaG NowakowskiF ReLM FogliattoP ScheinbergI FlinnC MoreiraM CzuczmanS KalambakasP FustierC WuJP Leonard

Long-term follow-up of previously untreated patients (pts) with chronic lymphocytic leukemia (CLL) treated with ofatumumab (OFA) and chlorambucil (CHL) : final analysis of the phase 3 COMPLEMENT 1 trial.

Fritz OffnerTadeusz RobakAnn JanssensGovind Babu KanakasettyJanusz KloczkoSebastian GrosickiJiri MayerPanagiotis PanagiotidisAnna SchuhAndrew PettittMarco MontilloOlena WernerGhislaine VincentSadhvi KhannaPeter Hillmen

Ofatumumab maintenance prolongs progression-free survival in relapsed chronic lymphocytic leukemia : final analysis of the PROLONG study

Marinus van OersLukas SmolejMario PetriniFritz OffnerSebastian GrosickiMark-David LevinJaclyn DavisHiya BanerjeeTommaso StefanelliPetra HoeverChristian Geisler

A1 Journal Article in BLOOD CANCER JOURNAL

Oral ixazomib maintenance following autologous stem cell transplantation (TOURMALINE-MM3) : a double-blind, randomised, placebo-controlled phase 3 trial

Meletios A. DimopoulosFrancesca GayFredrik SchjesvoldMeral BeksacRoman HajekKatja Christina WeiselHartmut GoldschmidtVladimir MaisnarPhilippe MoreauChang Ki MinAgnieszka PlutaWee-Joo ChngMartin KaiserSonja ZweegmanMaria-Victoria MateosAndrew SpencerShinsuke IidaGareth MorganKaveri SuryanarayanZhaoyang TengTomas SkacelAntonio PalumboAjeeta B. DashNeeraj GuptaRichard LabotkaS. Vincent Rajkumaron behalf of the TOURMALINE-MM3 study groupFritz Offner

A1 Journal Article in LANCET

Phase 1 first-in-human trial of the anti-CD37 antibody BI 836826 in relapsed/refractory chronic lymphocytic leukemia

Stephan StilgenbauerTherese Aurran SchleinitzBarbara EichhorstFabian LangFritz OffnerJean-Francois RossiWilfried SchroyensEric Van den NesteLoic YsebaertUte von WangenheimUta Ursula KressPetra BlumThorsten Zenz

A1 Journal Article in LEUKEMIA

Phase 2 results of the iR(2) Regimen (Ibrutinib, Lenalidomide, and Rituximab) in patients with Relapsed/Refractory (R/R) Non-Germinal Center B Cell-like (Non-GCB) Diffuse Large B-Cell Lymphoma (DLBCL)

Radhakrishnan RamchandrenPeter JohnsonNilanjan GhoshJia RuanKirit M. ArdeshnaRoderick JohnsonGregor VerhoefDavid CunninghamSven de VosShireen KassamLuis FayadJohn RadfordSarah BaillyFritz OffnerDavid MorganJavier MunozJerry PingKevin KweiKarl EckertJutta K. NeuenburgAndre Goy

Phase III randomized AUGMENT study of Lenalidomide/Rituximab vs Rituximab/Placebo in Patients with relapsed/refractory indolent non-hodgkin lymphoma

J. GribbenM. TrnenyK. IzutsuN. H. FowlerX. HongJ. ZhuH. ZhangFritz OffnerA. ScheligaG. NowakowskiA. PintoF. ReL. M. FogliattoP. ScheinbergI. FlinnC. MoreiraD. LiuS. KalambakasP. FustierC. WuJ. P. Leonard

Real world population-based exploration of the pathology subtyping and treatment-modalities of diffuse large B-cell lymphoma in Belgium in relation to survival

Willem DaneelsMichael RosskampGilles MacqEstabraq Ismael SaadoonAnke De GeyndtFritz OffnerHelene A Poirel

Sustained progression-free survival benefit of rituximab maintenance in patients with follicular lymphoma : long-term results of the PRIMA study

Emmanuel BachyJohn F. SeymourPierre FeugierFritz OffnerArmando Lopez-GuillermoDavid BeladaLuc XerriJohn V. CatalanoPauline BriceFrancois LemonnierAlejandro MartinOlivier CasasnovasLars M. PedersenVeronique DorvauxDavid SimpsonSirpa LeppaJean GabarreMaria G. da SilvaSylvie GlaisnerLoic YsebaertAnne VekhoffTanin IntragumtornchaiSteven Le GouillAndrew ListerJane A. EstellGustavo MiloneAnne SonetJonathan FarhiHarald ZeunerHerve TillyGilles Salles

A1 Journal Article in JOURNAL OF CLINICAL ONCOLOGY

The anaphase-promoting complex/cyclosome : a new promising target in diffuse large B-cell lymphoma and mantle cell lymphoma

Anke MaesKen MaesHendrik De RaeveEva De SmedtPhilip VlummensVanessa SzablewskiJulie DevinSylvia FaictKim De VeirmanEline MenuFritz OffnerMarcel SpaargarenJerome MoreauxKarin VanderkerkenEls Van ValckenborghElke De Bruyne

A1 Journal Article in BRITISH JOURNAL OF CANCER

The use of murine models for studying mechanistic insights of genomic instability in multiple myeloma

Philip VlummensKim De VeirmanEline MenuElke De BruyneFritz OffnerKarin VanderkerkenKen Maes

A1 Journal Article in FRONTIERS IN GENETICS

2018

A gene-expression profiling score for prediction of outcome in patients with follicular lymphoma : a retrospective training and validation analysis in three international cohorts

Sarah HuetBruno TessonJean-Philippe JaisAndrew L FeldmanLaura MagnanoEmilie ThomasAlexandra Traverse-GlehenBenoit AlbaudMarjorie CarrereLuc XerriStephen M AnsellLucile BaseggioCecile ReyesKarin TarteSandrine BoyaultCorinne HaiounBrian K LinkPierre FeugierArmando Lopez-GuillermoHerve TillyPauline BriceSandrine HayetteFabrice JardinFritz OffnerPierre SujobertDavid GentienAlain ViariElias CampoJames R CerhanGilles Salles

A1 Journal Article in LANCET ONCOLOGY

AUGMENT : a phase III randomized study of lenalidomide plus rituximab (R-2) vs rituximab/placebo in patients with relapsed/refractory indolent non-Hodgkin lymphoma

John P LeonardMarek TrnenyKoji IzutsuNathan H FowlerXiaonan HongJun ZhuHuilai ZhangFritz OffnerAdriana ScheligaGrzegorz S NowakowskiAntonio PintoFrancesca ReLaura Maria FogliattoPhillip ScheinbergIan W FlinnClaudia MoreiraDavid LiuStacey KalambakasPierre FustierChengqing WuJohn G Gribben

Argx-110 for treatment of CD70-positive advanced cutaneous T-cell lymphoma in a phase 1/2 clinical trial

Martine BagotMarie MaerevoetPier Luigi ZinzaniFritz OffnerFranck MorschhauserJean-Marie MichotVincent RibragMaxime BattistellaHelene MoinsAngelica CalleriStephane DalleMarie Beylot-BarryKaren ZwaenepoelKoen De WinnieAnne Marie-CardineJean-Michel CayuelaValentina TabanelliGiovanna MottaFederica MelleAnna HultbergDomenica GandiniTeresa MarafiotiMahan MoshirTim DelahayePiotr ZabrockiKaren SilenceLuc Van RompaeyArmand BensussanHans De HaardPatrick PauwelsNicolas LeupinStefano A Pileri

CD20-Tcb (RG6026), a novel '' 2:1 '' format T-cell-engaging bispecific antibody, induces complete remissions in relapsed/refractory B-cell non-Hodgkin's lymphoma : preliminary results from a phase I first in human trial

Martin HutchingsGloria IacoboniFranck MorschhauserFritz OffnerAnna SuredaGilles Andre SallesCarmelo Carlo-StellaJoaquin Martinez LopezDenise ThomasPeter N MorcosBetsy QuackenbushCristiano FerliniMarina BacacAnn-Marie E BroeskeNatalie DimierTom MooreMartin WeisserMichael Dickinson

Central nervous system relapse in patients over 80 years with diffuse large B-cell lymphoma : an analysis of two LYSA studies

Aurélie Cabannes-HamyFrederic PeyradeFabrice JardinJean-François EmileVincent DelwailNicolas MounierCorinne HaiounAurore PerrotOlivier FitoussiDiane LaraRichard DelarueMarc AndréFritz OffnerHerve GhesquièresLaurent PascalCarole SoussainJulien LazaroviciJean-Marc SchianoPhilippe GaulardHervé TillyCatherine Thieblemont

A1 Journal Article in CANCER MEDICINE

Characterization of the long-term efficacy and safety of duvelisib monotherapy in patients with relapsed/refractory CLL/SLL on treatment for > 2 years across 4 clinical studies

Ian W FlinnMarco MontilloZsolt NagyZoltan GasztonyiMatthew S DavidsKlaus GeisslerJose J Rifon RocaLeanne BerkhanFritz OffnerNgocDiep LeStephanie LustgartenJulio Delgado

Effect of combining glucocorticoids with Compound A on glucocorticoid receptor responsiveness in lymphoid malignancies

Dorien ClarisseKarlien Van WesemaelJan TavernierFritz OffnerIlse BeckKarolien De Bosscher

A1 Journal Article in PLOS ONE

Ibrutinib versus temsirolimus : 3-year follow-up of patients with previously treated mantle cell lymphoma from the phase 3, international, randomized, open-label RAY study

S RuleW JurczakM JerkemanC RusconiM TrnenyFritz OffnerD CaballeroC JoaoM Witzens-HarigG HessI Bence-BrucklerS-G ChoC ThieblemontW ZhouT HenningerJ GoldbergJ VermeulenM Dreyling

A1 Journal Article in LEUKEMIA

Moxetumomab pasudotox in relapsed/refractory hairy cell leukemia

Robert J KreitmanClaire DeardenPier Luigi ZinzaniJulio DelgadoLionel KarlinTadeusz RobakDouglas E GladstonePhilipp le CoutreSascha DietrichMirjana GoticLoree LarrattFritz OffnerGary SchillerRonan SwordsLarry BaconMonica BocchiaKrimo BouabdallahDimitri A BreemsAgostino CortelezziShira DinnerMichael DoubekBjorn Tore GjertsenMarco GobbiAndrzej HellmannStephane LepretreFrederic MaloiselFarhad RavandiPhilippe RousselotMathias RummelTanya SiddiqiTamar TadmorXavier TroussardCecilia Arana YiGiuseppe SaglioGail J RobozKemal BalicNathan StandiferPeng HeShannon MarshallWyndham WilsonIra PastanNai-Shun YaoFrancis Giles

A1 Journal Article in LEUKEMIA

Proteomic characterization of Withaferin A-targeted protein networks for the treatment of monoclonal myeloma gammopathies

Martin DomFritz OffnerWim Vanden BergheXaveer Van Ostade

A1 Journal Article in JOURNAL OF PROTEOMICS

Sustained efficacy and detailed clinical follow-up of first-line ibrutinib treatment in older patients with chronic lymphocytic leukemia : extended phase 3 results from RESONATE-2

Paul M BarrTadeusz RobakCarolyn OwenAlessandra TedeschiOsnat BaireyNancy L BartlettJan A BurgerPeter HillmenSteven CoutreStephen DevereuxSebastian GrosickiHelen McCarthyJianyong LiDavid SimpsonFritz OffnerCarol MorenoCathy ZhouLori StylesDanelle JamesThomas J KippsPaolo Ghia

A1 Journal Article in HAEMATOLOGICA

The iR(2) regimen (ibrutinib, lenalidomide, and rituximab) is active with a manageable safety profile in patients with relapsed/refractory non-germinal center-like diffuse large B-cell lymphoma

Radhakrishnan RamchandrenPeter JohnsonNilanjan GhoshJia RuanKirit M ArdeshnaRoderick JohnsonGregor VerhoefDavid CunninghamSven de VosShireen KassamLuis FayadJohn RadfordSarah BaillyFritz OffnerDavid MorganJavier MunozJerry PingMelannie CoJutta K NeuenburgAndre Goy

The light chain IgLV3-21 defines a new poor prognostic subgroup in chronic lymphocytic leukemia : results of a multicenter study

Basile StamatopoulosThomas SmithEmerence CrompotKarlien PietersRuth CliffordMarek MrazPauline RobbeAdam BurnsAdele TimbsDavid BrucePeter HillmenNathalie MeulemanPhilippe MineurRadu FirescuMarie MaerevoetVirginie De WildeAndre EfiraJan PhilippéBruno VerhasseltFritz OffnerDavid SimsAndreas HegerHelene DreauAnna Schuh

A1 Journal Article in CLINICAL CANCER RESEARCH

The phase 3 DUO trial : duvelisib vs ofatumumab in relapsed and refractory CLL/SLL

Ian W FlinnPeter HillmenMarco MontilloZsolt NagyArpad IllesGabriel EtienneJulio DelgadoBryone J KussConstantine S TamZoltan GasztonyiFritz OffnerScott LuninFrancesco BoschMatthew S DavidsNicole LamannaUlrich JaegerPaolo GhiaFlorence CymbalistaCraig A PortellAlan P SkarbnikAmanda F CashenDavid T WeaverVirginia M KellyBarry TurnbullStephan Stilgenbauer

A1 Journal Article in BLOOD

2017

Coregulator profiling of the glucocorticoid receptor in lymphoid malignancies

Dorien ClarisseJonathan ThommisKarlien Van WesemaelRene HoutmanDariusz RatmanJan TavernierFritz OffnerIlse BeckKarolien De Bosscher

A1 Journal Article in ONCOTARGET

Phase 1b/3 study of avelumab-based combination regimens in patients with relapsed or refractory diffuse large B-cell lymphoma (R/R DLBCL)

Robert W ChenStephen Maxted AnselPier Luigi ZinzaniJeffrey L VacircaArmando Lopez-GuillermoMartin HutchingsWojciech JurczakGeorg HessSteven Le GouillFritz OffnerArmando SantoroGilles A SallesDarla StypinskiDouglas LairdDmitri PavlovGiovanna AndreolaKolette D FlyAdrian WoolfsonGraham P Collins

Phase I dose-escalation study of the anti-CD70 antibody ARGX-110 in advanced malignancies

Philippe AftimosChristian RolfoSylvie RotteyFritz OffnerDominique BronMarie MaerevoetJean-Charles SoriaMahan MoshirTorsten DreierLuc Van RompaeyJean-Marie MichotKaren SilenceAnna HultbergDomenica GandiniHans de HaardVincent RibragMarc PeetersAlain ThibaultNicolas LeupinAhmad Awada

A1 Journal Article in CLINICAL CANCER RESEARCH

Safety and efficacy of abexinostat, a pan-histone deacetylase inhibitor, in non-Hodgkin lymphoma and chronic lymphocytic leukemia : results of a phase II study

Vincent RibragWon Seog KimReda BouabdallahSoon Thye LimBertrand CoiffierArpad IllesBernard LemieuxMartin JS DyerFritz OffnerZakia FelloussiIoana KloosYing LuanRemus VezanThorsten GraefFranck Morschhauser

A1 Journal Article in HAEMATOLOGICA

The impact of the updated IMWG diagnostic criteria in a real-life SMM cohort : a single center experience

Philip VlummensFritz Offner

2016

A phase 2, multicenter study investigating ofatumumab and bendamustine combination in patients with untreated or relapsed CLL

Ian W FlinnPanayiotis PanayiotidisBoris AfanasyevAnn JanssensSebastian GrosickiWojciech HomendaLukas SmolejKazimierz KuliczkowskiMichael DoubekNatalia DomnikovaSarah L WestChai-Ni ChangAlison M BarkerIra V GuptaOliver J WrightFritz Offner

A1 Journal Article in AMERICAN JOURNAL OF HEMATOLOGY

A phase I study in T cell lymphoma patients treated with anti-CD70 simple antibody (TM) ARGX-110

JM MichotM MaerevoetP AftimosSylvie RotteyC RolfoFritz OffnerL Van RompaeyM MoshirH de HaardK SilenceM BagotP PauwelsK ZwaenepoelA AwadaD BronV Ribrag

A phase I study in T cell lymphoma patients treated with anti-CD70 simple antibody T ARGX-110

JM MichotK SilenceM MaerevoetP AftimosS RotteyC RolfoFritz OffnerL Van RompaeyM MoshirH de HaardM BagotP PauwelsK ZwaenepoelA AwadaD BronV Ribrag

Carfilzomib and dexamethasone versus bortezomib and dexamethasone for patients with relapsed or refractory multiple myeloma (ENDEAVOR) : a randomised, phase 3, open-label, multicentre study

Meletios A DimopoulosPhilippe MoreauAntonio PalumboDouglas JoshuaLudek PourRoman HájekThierry FaconHeinz LudwigAlbert OriolHartmut GoldschmidtLaura RosiñolJan StraubAleksandr SuvorovCarla AraujoElena RimashevskayaTomas PikaGianluca GaidanoKatja WeiselVesselina Goranova-MarinovaAnthony SchwarerLeonard MinukTamás MassziIevgenii KaramaneshtMassimo OffidaniVania HungriaAndrew SpencerRobert Z OrlowskiHeidi H GillenwaterNehal MohamedShibao FengWee-Joo Chngfor the ENDEAVOR investigatorsFritz Offner

A1 Journal Article in LANCET ONCOLOGY

Carfilzomib weekly plus melphalan and prednisone in newly diagnosed elderly multiple myeloma (IFM 2012-03)

X LeleuG FouquetL KarlinB KolbM TiabC AraujoN MeulemanT de RevelP BourquardP LenainM RousselA JaccardMO PetillonK Belhadj-MerzougG LepeuML ChretienJ FontanP RodonA SchmittFritz OffnerL VoillatS CerejatF KuhnowskoS RigaudeauO DecauxC Humbrecht-KrautJ FrayferO FitoussiDR WeilJC EisenmannV DorvauxEG VoogC HulinM AttalP MoreauT Facon

Clinical response observed in a phase I study in T cell lymphoma patients treated with anti-CD70 SIMPLE antibody ARGX-110

Jean-Marie MichotMarie MaerevoetPhilippe Georges AftimosSylvie RotteyChristian Diego RolfoFritz OffnerLuc Van RompaeyMahan MoshirHans de HaardKaren SilencePatrick PauwelsKaren ZwaenepoelAhmad AwadaDominique BronVincent Ribrag

Combined evaluation of conventional MRI, dynamic contrast-enhanced MRI and diffusion weighted imaging for response evaluation of patients with multiple myeloma

Julie DutoitEveline ClausFritz OffnerLucien NoensJoris DelangheKoenraad Verstraete

A1 Journal Article in EUROPEAN JOURNAL OF RADIOLOGY

Daratumumab, lenalidomide, and dexamethasone for multiple myeloma

MA DimopoulosA OriolH NahiJ San-MiguelNJ BahlisSZ UsmaniN RabinRZ OrlowskiM KomarnickiK SuzukiT PlesnerS-S YoonD Ben YehudaPG RichardsonH GoldschmidtD ReeceS LisbyNZ KhokharL O'RourkeC ChiuX QinM GuckertT AhmadiP Moreaufor the POLLUX InvestigatorsFritz Offner

A1 Journal Article in NEW ENGLAND JOURNAL OF MEDICINE

Health-related quality of life and patient-reported outcomes of ofatumumab plus chlorambucil versus chlorambucil monotherapy in the COMPLEMENT 1 trial of patients with previously untreated CLL

Peter HillmenAnn JanssensK Govind BabuJanusz KloczkoSebastian GrosickiStephanie MansonAstrid McKeownIra GuptaChai-Ni ChangFritz Offner

A1 Journal Article in ACTA ONCOLOGICA

Xavier LeleuGuillemette FouquetLionel KarlinBrigitte KolbMourad TiabCarla AraujoNathalie MeulemanJv MalfusonPascal BourquardPascal LenainMurielle RousselArnaud JaccardMarie-Odile PetillonKarim Belhadj-MerzougGerard LepeuMarie-Lorraine ChretienJean FontanPhilippe RodonAnna SchmittFritz OffnerLaurent VoillatSophie CerejaFrederique KuhnowskiSophie RigaudeauOlivier DecauxCatherine Humbrecht-KrautJamile FrayferOlivier FitoussiDamien Roos WeilJean Claude EisenmannVeronique DorvauxEric G VoogCyrille HulinMichel AttalPhilippe MoreauThierry Facon

Ibrutinib combined with bendamustine and rituximab compared with placebo, bendamustine, and rituximab for previously treated chronic lymphocytic leukaemia or small lymphocytic lymphoma (HELIOS): a randomised, double-blind, phase 3 study

RS SilvaNL BartlettMS DilhuydyA AvigdorA MatoMA PavlovskyM MahlerM SalmanS SunC PhelpsS BalasubramanianA HowesM HallekS AssoulineI Bence-BrucklerR BucksteinG FraserL LarrattL MinukD VillaA AngevineN BartlettD BixbyP CaimiA Chanan-KhanM CraigA Forero-TorresS GangulyA GoyL HeffnerR HermannF LansiganJ LeisJ LetzerB LinkD LiuK McCaulE McGuireW SkinnerA StarodubR StuartM ThirmanN TirumaliJ YangA JanssensFritz OffnerE Van den NesteA Van HoofJ MayerJ NovakM TrnenyG CartronC DartigeasM DilhuydyD GhezC HaiounV LeblondG SallesC BalserP CramerP DregerJ DurigM EckartB HeinrichT IllmerK Jentsch-UllrichM PfreundschuhJ ScheteligR SchlagU SolingS StilgenbaueA AnagnostopoulosA DimopoulosP PanagiotidisE VrakidouO BaireyD Ben YehudaA BraesterR FinemanY HerishanuA NaglerR RuchlemerT TadmorS GrosickiW HomendaW JurczakA PlutaD WoszczykA Espirito SantoR LuisJ RaposoC ViveirosJ AlexeevaY DunaevM GolubevaN KhuagevaA LoginovI LysenkoE OsmanovV PavlovA PristupaA ProydakovV RossievI SamarinaO SamoilovaO SerdukT ShneiderD UdovitsaS VoloshinJ GayosoM GonzalezE Gonzalez BarcaJ Hernandez RivasI JargueJ LoscertalesC KarlssonM SenderM AktanO ArslanF DemirkanB FerhanogluL KaynarN SayinalpF VauralM YagciI DyagilP KaplanZ MasliakH OliynykT PopovskaH PylypenkoG RekhtmanC DeardenN MorleyP MossS RuleM PavlovskyD RiverosR Santucci-SilvaM RomeoA ScheligaL SalazarD GomezE RamirezC Jung

A1 Journal Article in LANCET ONCOLOGY

Ibrutinib versus temsirolimus in patients with relapsed or refractory mantle-cell lymphoma: an international, randomised, open-label, phase study

Martin DreylingWojciech JurczakMats JerkemanRodrigo Santucci SilvaChiara RusconiMarek TrnenyFritz OffnerDolores CaballeroCristina JoaoMathias Witzens-HarigGeorg HessIsabelle Bence-BrucklerSeok-Goo ChoJohn BothosJenna D GoldbergChristopher EnnyShana TrainaSriram BalasubramanianNibedita BandyopadhyaySteven SunJessica VermeulenAleksandra RizoSimon Rule

A1 Journal Article in LANCET

Improvement in hematologic function, disease burden/symptoms with ibrutinib in older treatment-naive (TN) patients with chronic lymphocytic leukemia (CLL) in phase 3 RESONATE-2 (TM)

P BarrT KippsT RobakA TedeschiC OwenP GhiaP HillmenFritz OffnerC MorenoC ZhouL StylesJ Burger

Improvement in quality of life and well-being in older patients with treatment-naive (TN) CLL : results from the randomized phase 3 study of ibrutinib (IBR) versus chlorambucil (CLB) (resonate-2™)

P GhiaA TedeschiPM BarrT RobakC OwenO BaireyP HillmenNL BartlettJ LiD SimpsonS GrosickiS DevereuxH McCarthyS CoutreFritz OffnerC MorenoC ZhouL StylesDF JamesTJ KippsJA Burger

International, randomized phase 3 study results : Ibrutinib versus Chlorambucil in patients 65 years and older with treatment-naive CLL (RESONATE-2 (TM))

J BurgerA TedeschiPM BarrT RobakC OwenP GhiaO BaireyP HillmenNL BartlettJ LiD SimpsonS GrosickiS DevereuxH MccarthyS CoutreH QuachG GaidanoZ MaslyakDA StevensA JanssensFritz OffnerJ MayerM O'DwyerA HellmannA SchuhT SiddiqiA PolliackCS TamD SuriM ChengF ClowL StylesDF JamesTJ Kipps

Mimicking the tumour microenvironment of chronic lymphocytic leukaemia in vitro critically depends on the type of B-cell receptor stimulation

Ans RomboutSofie LustFritz OffnerEvelien NaessensBruno VerhasseltJan Philippé

A1 Journal Article in BRITISH JOURNAL OF CANCER

Plasma exposure to metabolites of monomethyl auristatin E (MMAE) in patients with relapsed/refractory Hodgkin lymphoma (HL) treated with brentuximab vedotin (BV)

A FasanmadeJ KinleyM BargfredeT WyantK VenkatakrishnanM QianM CwikM PatonSK BalaniI PurevjalD HuebnerL GriskeviciusFritz Offner

Randomized, double-blind, phase III trial of enzastaurin versus placebo in patients achieving remission after first-line therapy for high-risk diffuse large B-cell lymphoma

Michael CrumpSirpa LeppäLuis FayadJe Jung LeeAlice Di RoccoMichinori OguraHans HagbergFrederick SchnellRobert RifkinAndreas MackensenFritz OffnerLauren Pinter-BrownSonali SmithKensei TobinaiSu-Peng YehEric D HsiTuan NguyenPeipei ShiMarjo Hahka-KemppinenDon ThorntonBoris LinBrad KahlNorbert SchmitzKerry J SavageThomas Habermann

A1 Journal Article in JOURNAL OF CLINICAL ONCOLOGY

Results from the international, randomized phase 3 study of ibrutinib versus chlorambucil in patients 65 years and older with treatment-naive (TN) CLL/SLL (RESONATE-2 (TM))

P HillmenA TedeschiPM BarrT RobakC OwenP GhiaO BaireyNL BartlettJ LiD SimpsonS GrosickiS DevereuxH McCarthyS CoutreH QuachG GaidanoZ MaslyakDA StevensA JanssensFritz OffnerJ MayerM O'DwyerA HellmannA SchuhT SiddiqiA PollackCS TamD SuriC ZhouF ClowL StylesDF JamesTJ KippsJA Burger

Risk factors and outcomes for patients with follicular lymphoma who had histologic transformation after response to first-line immunochemotherapy in the PRIMA trial

Clémentine SarkozyMarek TrnenyLuc XerriNick WickhamPierre FeugierSirpa LeppäPauline BricePierre SoubeyranMaria Gomes Da SilvaChristiane MounierFritz OffnerJehan DupuisDolores CaballeroDanielle CanioniMarlton PaulaRichard DelaruePierre ZacheeJohn SeymourGilles SallesHervé Tilly

A1 Journal Article in JOURNAL OF CLINICAL ONCOLOGY

Selective glucocorticoid receptor-activating adjuvant therapy in cancer treatments

Nora SundahlDorien ClarisseMarc BrackeFritz OffnerWim Vanden BergheIlse Beck

A2 Journal Article in ONCOSCIENCE

The mineralocorticoid receptor is involved in glucocorticoid resistance

Dorien ClarisseFritz OffnerKarolien De BosscherIlse Beck

Updated efficacy and safety from the phase 3 resonate-2 study : ibrutinib as first-line treatment option in patients 65 years and older with chronic lymphocytic leukemia/small lymphocytic leukemia

Paul BarrTadeusz RobakCarolyn J OwenAlessandra TedeschiOsnat BaireyNancy L BartlettJan BurgerPeter HillmenSteven CoutreStephen DevereuxSebastian GrosickiHelen McCarthyJianyong LiDavid SimpsonFritz OffnerCarol MorenoCathy ZhouLori StylesDanelle F JamesThomas J KippsPaolo Ghia

Updated outcomes and impact of age with lenalidomide and low-dose dexamethasone or melphalan, prednisone, and thalidomide in the randomized, phase III FIRST trial

Cyrille HulinAndrew BelchChaim ShustikMaria Teresa PetrucciUlrich DührsenJin LuKevin SongPhilippe RodonBrigitte PégouriéLaurent GarderetHannah HunterIsabelle AzaisRichard EekHeinz GisslingerMargaret MacroShaker DakhilCristina GoncalvesRichard LeBlancKen RomerilBruno RoyerChantal DoyenXavier LeleuFritz OffnerNicolas LeupinVanessa HouckGuang ChenAnnette Ervin-HaynesMeletios A DimopoulosThierry Facon

A1 Journal Article in JOURNAL OF CLINICAL ONCOLOGY

VANTAGE 095: an international, multicenter, open-label study of vorinostat (MK-0683) in combination with bortezomib in patients with relapsed and refractory multiple myeloma

David S SiegelMeletios DimopoulosSundar JagannathHartmut GoldschmidtSimon DurrantJonathan L KaufmanXavier LeleuArnon NaglerFritz OffnerThorsten GraefJoseph E EidJennifer HoupChristine GauseScott VuocoloKenneth C Anderson

A1 Journal Article in CLINICAL LYMPHOMA MYELOMA & LEUKEMIA

2015

A phase I dose-escalation study of antibody BI-505 in relapsed/refractory multiple myeloma

Markus HanssonPeter GimsingAshraf BadrosTitti Martinsson NiskanenHareth NahiFritz OffnerMorten SalomoElisabeth SonessonMorten Mau-SorensenYvonne StenbergAnnika SundbergIngrid TeigeJan Van DroogenbroeckStina WichertMaurizio ZangariBjörn FrendeusMagnus KorsgrenMartine PoelmanGuido Tricot

A1 Journal Article in CLINICAL CANCER RESEARCH

Carfilzomib weekly plus melphalan and prednisone in newly diagnosed elderly multiple myeloma (IFM 2012-03)

Xavier LeleuLionel KarlinBrigitte KolbMourad TiabCarla AraujoNathalie MeulemanThierry De RevelPascal BourquardPascal LenainMurielle RousselArnaud JaccardMarie-Odile PetillonKarim Belhadj-MerzougGerard LepeuMarie-Lorraine ChretienJean FontanPhilippe RodonAnna SchmittFritz OffnerLaurent VoillatSophie CerejaFrederique KuhnowskiSophie RigaudeauOlivier DecauxCatherine Humbrecht-KrautJamile FrayferOlivier FitoussiDamien Roos WeilJean Claude EisenmannVeronique DorvauxEric G VoogCyrille HulinMichel AttalPhilippe MoreauThierry Facon

Chimeric antigen receptor transgenic, T cell receptor/CD3 negative monospecific T cells generated from cord blood CD34 positive cells

Yasmine Van CaeneghemGlenn GoetgelukKarin WeeningGreet VerstichelSarah BonteTom TaghonGeorges LeclercqFritz OffnerHinrich AbkenTessa KerreBart Vandekerckhove

Chlorambucil plus ofatumumab versus chlorambucil alone in previously untreated patients with chronic lymphocytic leukaemia (COMPLEMENT 1): a randomised, multicentre, open-label phase 3 trial

Peter HillmenTadeusz RobakAnn JanssensK Govind BabuJanusz KloczkoSebastian GrosickiMichael DoubekPanagiotis PanagiotidisEva KimbyAnna SchuhAndrew R PettittThomas BoydMarco MontilloIra V GuptaOliver WrightIestyn DixonJodi L CareyChai-Ni ChangSteen LisbyAstrid McKeownFritz Offner

A1 Journal Article in LANCET

Combination of dexamethasone with the selective glucocorticoid receptor modulator, Compound A, does not enhance glucocorticoid responsiveness in lymphoid malignancies

Dorien ClarisseFritz OffnerMarc BrackeKarolien De BosscherIlse Beck

Effect of age on efficacy and safety outcomes in patients with newly diagnosed multiple myeloma receiving lenalidomide and low-dose dexamethasone (RD): the first trial

C HulinC ShustikA BelchMT PetrucciU DuehrsenJ LuK SongP RodonB PegourieL GarderetH HunterI AzaisR EekM MacroS DakhilV HouckG ChenA Ervin-HaynesFritz OffnerMA DimopoulosT Facon

Effect of prognostic classification on temsirolimus efficacy and safety in patients with relapsed or refractory mantle cell lymphoma : a retrospective analysis

Georg HessBertrand CoiffierMichael CrumpChristian GisselbrechtFritz OffnerJorge RomagueraLisa KangPadraig J. Moran

A2 Journal Article in EXPERIMENTAL HEMATOLOGY & ONCOLOGY

Frontline rituximab, cyclophosphamide, doxorubicin, and prednisone with bortezomib (VR-CAP) or vincristine (R-CHOP) for non-GCB DLBCL

Fritz OffnerOlga SamoilovaEvgenii OsmanovHyeon-Seok EomMax S ToppJoão RaposoViacheslav PavlovDeborah RicciShalini ChaturvediEugene ZhuHelgi van de VeldeChristopher EnnyAleksandra RizoBurhan Ferhanoglu

A1 Journal Article in BLOOD

Health related quality of life and patient reported outcomes in patients receiving ofatumumab maintenance versus observation in the Prolong trial

M van OersK KuliczkowskiL SmolejM PetriniFritz OffnerS GrosickiMD LevinI GuptaJ PhillipsV WilliamsS MansonS LisbyC Geisler

Ibrutinib as initial therapy for patients with chronic lymphocytic leukemia

JA BurgerA TedeschiPM BarrT RobakC OwenP GhiaO BaireyP HillmenNL BartlettJ LiD SimpsonS GrosickiS DevereuxH McCarthyS CoutreH QuachG GaidanoZ MaslyakDA StevensA JanssensFritz OffnerJ MayerM O'DwyerA HellmannA SchuhT SiddiqiA PolliackCS TamD SuriM ChengF ClowL StylesDF JamesTJ Kipps

A1 Journal Article in NEW ENGLAND JOURNAL OF MEDICINE

Ibrutinib vs temsirolimus: results from a phase 3, international, randomized, open-label, multicenter study in patients with previously treated mantle cell lymphoma (MCL)

Simon RuleWojciech JurczakMats JerkemanRodrigo SantucciChiara RusconiMarek TrnenyFritz OffnerDolores CaballeroCristina JoaoMathias Witzens-HarigGeorg HessIsabelle Bence-BrucklerSeok-Goo ChoSriram BalasubramanianNibedita BandyopadhyaySteven SunJenna GoldbergJohn BothosShana TrainaChristopher EnnyAleksandra RizoJessica VermeulenMartin H Dreyling

Lipoprotein lipase SNPs rs13702 and rs301 correlate with clinical outcome in chronic lymphocytic leukemia patients

Ans RomboutBasile StamatopoulosLaurence LagneauxSofie LustFritz OffnerEvelien NaessensHanne VanderstraetenBruno VerhasseltJan Philippé

A1 Journal Article in PLOS ONE

Mimicking the tumor microenvironment of chronic lymphocytic leukemia in vitro critically depends on the type of B cell receptor stimulation

Ans RomboutSofie LustFritz OffnerEvelien NaessensBruno VerhasseltJan Philippé

Ofatumumab maintenance versus observation in relapsed chronic lymphocytic leukaemia (PROLONG): an open-label, multicentre, randomised phase 3 study

Marinus HJ van OersKazimierz KuliczkowskiLukáš SmolejMario PetriniFritz OffnerSebastian GrosickiMark-David LevinIra GuptaJennifer PhillipsVanessa WilliamsStephanie MansonSteen LisbyChristian Geisler

A1 Journal Article in LANCET ONCOLOGY

Overall survival of relapsed and refractory multiple myeloma patients after adjusting for crossover in the MM-003 trial for pomalidomide plus low-dose dexamethasone

Gareth MorganAntonio PalumboSujith DhanasiriDawn LeeKatja WeiselThierry FaconMichel DelforgeAlbert OriolMohamed ZakiXin YuLars SternasChristian JacquesRon AkehurstFritz OffnerMeletios A Dimopoulos

A1 Journal Article in BRITISH JOURNAL OF HAEMATOLOGY

Phase I, first-in-human trial of BI 836826 (an anti-CD37 antibody) in patients (PTS) with relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL)

S StilgenbauerT Aurran SchleinitzM HallekF LangFritz OffnerJ-F RossiW SchroyensE Van Den NesteL YsebaertP BlumJ HockeUU KressT Zenz

Randomized phase II trial comparing obinutuzumab (GA101) with rituximab in patients with relapsed CD20⁺ indolent B-cell non-Hodgkin lymphoma: final analysis of the GAUSS study

Laurie H SehnAndre GoyFritz OffnerGiovanni MartinelliM Dolores CaballeroOle GadebergTara BaetzAndrew D ZelenetzGianluca GaidanoLuis E FayadRena BucksteinJonathan W FriedbergMichael CrumpBranimir JaksicPier Luigi ZinzaniSwaminathan Padmanabhan IyerDeniz SahinAkiko ChaiGünter Fingerle-RowsonOliver W Press

A1 Journal Article in JOURNAL OF CLINICAL ONCOLOGY

Results from the international, randomized phase 3 study of ibrutinib versus chlorambucil in patients 65 years and older with treatment-naive CLL/SLL (RESONATE-2 (TM))

Alessandra TedeschiPaul M BarrTadeusz RobakCarolyn OwenPaolo GhiaOsnat BaireyPeter HillmenNancy L BartlettJianyong LiDavid SimpsonSebastian GrosickiStephen DevereuxHelen McCarthySteven CoutreHang QuachGianluca GaidanoZvenyslava MaslyakDon A StevensAnn JanssensFritz OffnerJiri MayerMichael O'DwyerAndrzej HellmannAnna SchuhTanya SiddiqiAaron PolliackConstantine S TamMichael KeatingDeepali SuriCathy ZhouFong ClowLori StylesDanelle F JamesThomas J KippsJan A Burger

Results of a phase II study of bendamustine and ofatumumab in untreated indolent B cell non-Hodgkin's lymphoma

Myron S CzuczmanStephen KahanicAndres ForeroGlen DavisMihaela MunteanuEric Van den NesteFritz OffnerDominique BronDonald QuickNathan Fowler

A1 Journal Article in ANNALS OF HEMATOLOGY

Symptoms and toxicity of rituximab maintenance relative to observation following immunochemotherapy in patients with follicular lymphoma

Xiaolei ZhouJianmin WangJessica ZhangCatherine Copley-MerrimanYasuhiro TorigoeCarolina ReyesJohn F SeymourFritz OffnerMarek TrnenyGilles Andre Salles

A1 Journal Article in HEMATOLOGY

Telomere length and POT1 mutations in CLL: incidence, associations and clinical impact in the Complement 1 trial

BM Chelliah JebarajE TauschR SchlenkS KlessC GallerP HillmenFritz OffnerA JanssensT ZenzK GovindbabuS GrosickiJ MayerP PanagiotidisA McKeownI GuptaH DoehnerS Stilgenbauer

2014

A phase I first-in-human study of ARGX-110, a monoclonal antibody targeting CD70, a receptor involved in immune escape and tumor growth in patients with solid and hematologic malignancies

Ahmad AwadaChristian D RolfoSylvia RotteyLaure Ysebrant de LendonckWilfrled A SchroyensFritz OffnerKaren SilenceTorsten DreierMahan MoshirHans de HeardMarc PostersDominique BronAlain ThibaultPhilippe G Aftimos

Abexinostat (S78454) a histone deacetylase inhibitor, in patients with refractory or relapsed Hodgkin's lymphoma, non-Hodgkin lymphoma and chronic lymphocytic leukaemia: preliminary phase II results

F Broussais-GuillaumotF MorschhauserL TerriouWS KimST LimM EgyedB CoiffierE BachyMJ DyerA IllesA RostaB LemieuxKL WuSS YoonS KimZ GasztonyiJ JakucsFritz OffnerE Van den NesteL YsebaertCM WendtnerI KloosAL SarryS MalasseV Ribrag

DUO: a phase 3 trial of the PL3K-delta,gamma inhibitor IPI-145 versus ofatumumab in patients with relapsed or refractory chronic lymphocytic leukemia or small lymphorytic lymphoma

Ian FlinnUlrich JaegerFritz OffnerFlorence CymbalistaMichael HallekFederico Callgarls-CapploJulio DelgadoPeter HillmanMatthew Steven DavidsDavid Donald WrightJames H EasellBartrum W BakerWalter CosoloPatrick Francis KellyPatricia HarrisLixin HanFiona PattersonStephan Stilgenbauer

Effect of age on efficacy and safety outcomes in patients (Pts) with newly diagnosed multiple myeloma (NDMM) receiving lenalidomide and low-dose dexamethasone (Rd): the first trial

Cyrille HulinThierry FaconChaim ShustikAndrew BelchMaria Teresa PetrucciUlrich DuehrsenJin LuKevin SongPhilippe RodonBrigitte PegourieLaurent GarderetHannah HunterIsabelle AzaisRichard EekMargaret MacroShaker DakhilVanessa HouckGuang ChenAnnette Ervin-HaynesFritz Offner

Gene mutations and treatment outcome in CLL patients treated with chlorambucil (Chl) or ofatumumab-Chl (O-Chl): results from the phase III study COMPLEMENT1 (OMB110911)

Eugen TauschChristina GallerRichard SchlenkPeter HillmenFritz OffnerAnn JanssensK GovindbabuJiri MayerSebastian GrosickiPanagiotis PanagiotidisDaniel MertensAstrid McKeownIra GuptaHartmut DoehnerStephan Stilgenbauer

Ofatumumab (OFA) maintenance prolongs PFS in relapsed CLL: prolong study interim analysis results

Marinus HJ van OersKazimierz KuliczkowskiLukas SmolejMario PetriniFritz OffnerSebastian GorsickiMark-David LevinIra GuptaJennifer PhillipsVanessa WilliamsSteen LisbyChristian Geisler

Overall survival of patients with relapsed and refractory multiple myeloma: adjusting for crossover in the MM-003 trial for pomalidomide plus low-dose dexamethasone vs. high-dose dexamethasone

G MorganJF San MiguelS DhanasiriD LeeA PalumboT FaconM ZakiX YuL SternasC JacquesK WeiselFritz OffnerM Dimopoulos

Peripheral blood involvement in patients with follicular lymphoma: a rare disease manifestation associated with poor prognosis

Clémentine SarkozyLucile BaseggioPierre FeugierEvelyne Callet-BauchuLionel KarlinJohn F SeymourLaure LebrasAnne-Sophie MichalletFritz OffnerOlivier DumasAlexandra Traverse-GlehenMartine FfrenchArmando Lopez-GuillermoFrançoise BergerBertrand CoiffierPascale FelmanGilles Salles

A1 Journal Article in BRITISH JOURNAL OF HAEMATOLOGY

Phase IA/II, multicentre, open-label study of the CD40 antagonistic monoclonal antibody lucatumumab in adult patients with advanced non-Hodgkin or Hodgkin lymphoma

Michelle FanaleSarit AssoulineJohn KuruvillaPhilippe Solal-CélignyDae S HeoGregor VerhoefPaolo CorradiniJeremy S AbramsonFritz OffnerAndreas EngertMartin JS DyerDaniel CarreonBrett EwaldJohan BaeckAnas YounesArnold S Freedman

A1 Journal Article in BRITISH JOURNAL OF HAEMATOLOGY

Polyfunctional tumor antigen-specific T cells generated in vitro from human CD34 positive precursor cells transduced to express T cell receptor alpha beta chains fused to CD28-CD3 zeta signaling cassette

Yasmine Van CaeneghemGlenn GoetgelukSYLVIA SNAUWAERTFritz OffnerReno DebetsTessa KerreBart Vandekerckhove

Pomalidomide plus low-dose dexamethasone (POM plus LoDEX) versus high-dose dexamethasone (HiDEX) for relapsed or refractory multiple myeloma (RRMM): overall survival (OS) results of MM-003 after adjustment for Res crossover

Gareth J MorganJesus San MiguelSujith DhanasiriDawn LeeAntonio PalumboThierry FaconMohamed H ZakiXin YuLars Axel SternasChristian JacquesKatja C WeiselFritz OffnerMeletios A Dimopoulos

Quantitative proteomics to characterize specific histone H2A proteolysis in chronic lymphocytic leukemia and the myeloid THP-1 cell line

Pieter GlibertLiesbeth VossaertKatleen Van SteendamStijn LambrechtFilip Van NieuwerburghFritz OffnerThomas KippsMaarten DhaenensDieter Deforce

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

SF3B1 mutations and outcome in CLL patients treated with chlorambucil (CHL) or ofatumumab-CHL (O plus CHL): results from the phase III study complement 1 (OMB110911)

E TauschC GallerRF SchlenkP HillmenFritz OffnerA JanssensK GovindbabuS GrosickiJ MayerP PanagiotidisA McKeownPD WinterIV GuptaH DohnerS Stilgenbauer

2013

A phase III study of enzastaurin in patients with high-risk diffuse large B cell lymphoma following response to primary treatment: the prelude trial

Michael CrumpSirpa LeppaLuis E FayadJe-Jung LeeAlice Di RoccoMichinori OguraHans HagbergFrederick SchnellRobert M RifkinAndreas MackensenFritz OffnerLauren Pinter-BrownSonali M SmithKensei TobinaiSu-Peng YehJun ZhuMarjo Hahka-KemppinenDonald ThorntonPeipei ShiBoris LinBrad S KahlNorbert SchmitzKerry J SavageThomas M Habermann

ER stress in diffuse large B cell lymphoma: GRP94 is a possible biomarker in germinal center versus activated B-cell type

Jerina BoelensJean-Philippe JaisBarbara VanhoeckeIlse BeckHeleen Van MelckebekeJan PhilippéMarc BrackeFabrice JardinJosette BrièreKaren LeroyFritz OffnerSofie Lust

A1 Journal Article in LEUKEMIA RESEARCH

Efficacy and toxicity of two schedules of bortezomib in patients with recurrent or refractory follicular lymphoma: a randomised phase II trial from the Groupe d'Etude des Lymphomes de l'Adulte (GELA)

Vincent RibragHervé TillyOlivier CasasnovasAndré BoslyReda BouabdallahRichard DelarueFrançois BoueDominique BronPierre FeugierCorinne HaiounFritz OffnerBertrand Coiffier

A1 Journal Article in EUROPEAN JOURNAL OF CANCER

Glucocorticoids and tailored targeting of the unfolded protein response: searching for novel apoptosis inducing pathways in mature B-cell neoplasms

Jerina BoelensFritz Offner

In vitro apoptosis and clonal evolution in chronic lymphocytic leukemia : predictive value and possible influence on treatment

Ann JanssensFritz OffnerJan Philippé

NOTCH1 mutation and treatment outcome in CLL patients treated with chlorambucil (Chl) or ofatumumab-chi (O-Chl): results from the phase III study complement 1 (OMB110911)

Eugen TauschPhilipp BeckRichard F SchlenkSabrina KlessChristina GallerPeter HillmenFritz OffnerAnn JanssensK GovindbabuSebastian GrosickiJiri MayerPanagiotis PanagiotidisSusanne Danhauser-RiedlAstrid McKeownPaul DPB WinterIra V GuptaHartmut DohnerStephan Stilgenbauer

Ofatumumab plus chlorambucil versus chlorambucil alone in patients with untreated chronic lymphocytic leukemia (CLL): results of the phase III study complement 1 (OMB110911)

Peter HillmenTadeusz RobakAnn JanssensK GovindbabuSebastian GrosickiJiri MayerPanagiotis PanagiotidisEva KimbyAnna SchuhThomas BoydMarco MontilloAstrid McKeownJodi L CareyIra V GuptaChai-Ni ChangSteen LisbyFritz Offner

Prespecified candidate biomarkers identify follicular lymphoma patients who achieved longer progression-free survival with bortezomib-rituximab versus rituximab

Bertrand CoiffierWeimin LiErin D HenitzJayaprakash D KarkeraReyna FavisDana GaffneyAlice ShapiroPanteli TheocharousYusri A ElsayedHelgi van de VeldeMichael E SchafferEvgenii A OsmanovXioanan HongAdriana ScheligaJiri MayerFritz OffnerSimon RuleAdriana TeixeiraJoanna Romejko-JarosinskaSven de VosMichael CrumpOfer ShpilbergPier Luigi ZinzaniAndrew CakanaDixie-Lee EsseltineGeorge MulliganDeborah Ricci

A1 Journal Article in CLINICAL CANCER RESEARCH

SAR245409 Monotherapy in relapsed/refractory follicular lymphoma: preliminary results from the phase II ARD12130 study

Jennifer R BrownMehdi HamadaniJon ArnasonLionel KarlinJohn HayslipNina Wagner-JohnstonGuillaume CartronVincent RibragSophie de GuibertStephen OpatHervé TillyPaul CannelAnn JanssensFritz OffnerSiddhartha GangulySikander AilawadhiMichael MillensonDominique BronYi XuRodrigo Ruiz-SotoMarie José Kersten

Safety and clinical activity of a combination therapy comprising two antibody-based targeting agents for the treatment of non-Hodgkin lymphoma: results of a phase I/II study evaluating the immunoconjugate inotuzumab ozogamicin with rituximab

Luis FayadFritz OffnerMitchell R SmithGregor VerhoefPeter JohnsonJonathan L KaufmanAma RohatinerAnjali AdvaniJames ForanGeorg HessBertrand CoiffierMyron CzuczmanEva GineSimon DurrantMichelle KneisslKenneth T LuuSteven Y HuaJoseph BoniErik VandendriesNam H Dang

A1 Journal Article in JOURNAL OF CLINICAL ONCOLOGY

Safety profile and clinical response to MEDI-551, a humanized monoclonal anti-CD19, in a phase 1/2 study in adults with relapsed or refractory advanced B-cell malignancies

Andres Forero-TorresMehdi HamadaniMichelle A FanaleCeleste M BelloThomas J KippsFritz OffnerGregor VerhoefMassimo FedericoStephanie A GregoryAnne SonetSarit AssoulineJaime Perez de OteyzaJosé Francisco TomasAntonio CuneoNairouz ElgeioushiTrishna GoswamiRamy IbrahimRonald HerbstBruce D Cheson

Updated 6 year follow-up of the PRIMA study confirms the benefit of 2-year rituximab maintenance in follicular lymphoma patients responding to frontline immunochemotherapy

Gilles André SallesJohn Francis SeymourPierre FeugierFritz OffnerArmando Lopez-GuillermoDavid BeladaLuc XerriReda BouabdallahJohn CatalanoBrice PaulineDolores CaballeroCorinne HaiounLars Møller PedersenAlain DelmerDavid SimpsonSirpa LeppaPierre SoubeyranAnton HagenbeekOlivier CasasnovasTanin IntragumtornchaiChristophe FermeMaria Gomes da SilvaCatherine SebbanAndrew ListerJane A EstellGustavo MiloneAnne SonetBertrand CoiffierNerve Tilly

2012

Clinical outcome of patients with follicular lymphoma receiving chemoimmunotherapy in the PRIMA study is not affected by FCGR₃A and FCGR₂A polymorphisms

Hervé GhesquièresGuillaume CartronJohn Francis SeymourMarie-Hélène Delfau-LarueFritz OffnerPierre SoubeyranAurore PerrotPauline BriceRéda BouabdallahAnne SonetJehan DupuisOlivier CasasnovasJohn Vincent CatalanoAlain DelmerFabrice JardinAurélie VerneyPeggy DartiguesGilles Salles

A1 Journal Article in BLOOD

Early recognition of malignant lactic acidosis in clinical practice: report on 6 patients with haematological malignancies

EA De RaesDominique BenoitPieter DepuydtFritz OffnerJ NolletANNA VANTILBORGHEVA STEELLucien NoensJohan Decruyenaere

A1 Journal Article in ACTA CLINICA BELGICA

High-risk clonal evolution in chronic B-lymphocytic leukemia: single-center interphase fluorescence in situ hybridization study and review of the literature

Ann JanssensNadine Van RoyBruce PoppeLucien NoensJan PhilippéFranki SpelemanFritz Offner

A1 Journal Article in EUROPEAN JOURNAL OF HAEMATOLOGY

2011

Bortezomib plus rituximab versus rituximab alone in patients with relapsed, rituximab-naive or rituximab-sensitive, follicular lymphoma: a randomised phase 3 trial

Bertrand CoiffierEvgenii A OsmanovXiaoNan HongAdriana ScheligaJiri MayerFritz OffnerSimon RuleAdriana TeixeiraJan WalewskiSven de VosMichael CrumpOfer ShpilbergDixie-Lee EsseltineEugene ZhuChristopher EnnyPanteli TheocharousHelgi van de VeldeYusri A ElsayedPier Luigi Zinzani

A1 Journal Article in LANCET ONCOLOGY

Efficacy and safety of bortezomib-rituximab (VCR) vs rituximab® in patients (PTS) with relapsed, R-naive/-sensitive follicular lymphoma (FL): outcome according to prior therapy

M CrumpA ScheligaJ MayerFritz OffnerA TeixeiraK KuliczkowskiAM LiberatiCY OkadaDL EsseltineC EnnyE ZhuH Van de VeldeYA ElsayedB Coiffier

FCGR3A polymorphism does not significantly affect response and outcome of follicular lymphoma patients treated in the PRIMA study with rituximab and chemotherapy followed by rituximab maintenance or observation

H GhesquieresJ SeymourFritz OffnerP FeugierP BriceC HaiounO CasasnovasJ CatalanoF JardinL XerriG Salles

Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma

Ioanna PapandreouNicholas C DenkoMichael OlsonHeleen Van MelckebekeSofie LustArvin TamDavid E Solow-CorderoDonna M BouleyFritz OffnerMaho NiwaAlbert C Koong

A1 Journal Article in BLOOD

Impact of induction chemotherapy regimen on response, safety and outcome in the PRIMA study

F MorschhauserJ SeymourP FeugierFritz OffnerA Lopez-GuillermoR BouabdallahL PedersenP BriceD BeladaL XerriG Salles

Laser microdissection for the assessment of the clonal relationship between chronic lymphocytic leukemia/small lymphocytic lymphoma and proliferating B cells within lymph node pseudofollicles

Mado VandewoestyneValerie PedeKathleen LambeinMaarten DhaenensFritz OffnerMarleen PraetJan PhilippéThomas J KippsDieter Deforce

A1 Journal Article in LEUKEMIA

Lenalidomide in relapsed refractory myeloma patients: impact of previous response to bortezomib and thalidomide on treatment efficacy: results of a medical need program in Belgium

M DelforgeA MichielsC DoyenA KentosJ Van DroogenbroeckFritz OffnerG BriesH DemuynckMC VekemansN MeulemanP MineurC RavoetB DepryckA Van de VeldeP PierreKL WuR Schots

A1 Journal Article in ACTA CLINICA BELGICA

Myeloma of the central nervous system: report of a single center case series

P VermeirenANNA VANTILBORGHFritz Offner

A1 Journal Article in ACTA CLINICA BELGICA

Neutrophil elastase is the 'histone H2A-specific protease'

Pieter GlibertMaarten DhaenensStijn LambrechtDirk ElewautFritz OffnerTJ KippsDieter Deforce

Outcome in critically ill patients with allogeneic BM or peripheral haematopoietic SCT : a single-centre experience

Pieter DepuydtTessa KerreLucien NoensJOKE NOLLETFritz OffnerJohan DecruyenaereDominique Benoit

A1 Journal Article in BONE MARROW TRANSPLANTATION

Pattern of infections observed during the maintenance phase in the PRIMA study

M BouteloupJ SeymourP FeugierFritz OffnerA Lopez-GuillermoR BouabdallahL PedersenP BriceD BeladaG Salles

Phase 2 studies of immunochemotherapy +/- bortezomib (VC) in newly diagnosed non-germinal center B-cell-like (GCB) DLBCL: rapid prospective identification of non-GCB patients (PTS)

Fritz OffnerB FerhanogluJA ReevesHS EomK DonerJ RaposoIW FlinnC SuhNM ChowhanS PrasadSJ KussickG MulliganA RizoJP Leonard

Rituximab maintenance for 2 years in patients with high tumour burden follicular lymphoma responding to rituximab plus chemotherapy (PRIMA): a phase 3, randomised controlled trial

Gilles SallesJohn Francis SeymourFritz OffnerArmando López-GuillermoDavid BeladaLuc XerriPierre FeugierRéda BouabdallahJohn Vincent CatalanoPauline BriceDolores CaballeroCorinne HaiounLars Moller PedersenAlain DelmerDavid SimpsonSirpa LeppaPierre SoubeyranAnton HagenbeekOlivier CasasnovasTanin IntragumtornchaiChristophe FerméMaria Gomes da SilvaCatherine SebbanAndrew ListerJane A EstellGustavo MiloneAnne SonetMyriam MendilaBertrand CoiffierHervé Tilly

A1 Journal Article in LANCET

Rituximab maintenance for 2 years in patients with high tumour burden follicular lymphoma responding to rituximab plus chemotherapy (PRIMA): a phase 3, randomised controlled trial (vol 377, pg 42, 2011)

Gilles SallesJohn Francis SeymourFritz Offner

Rituximab maintenance therapy for follicular lymphoma: reply

Gilles SallesJohn Francis SeymourFritz OffnerArmando Lopez-GuillermoLarissa MegeHervé Tilly

A1 Journal Article in LANCET

Time to next anti-lymphoma therapy (TTNT) and treatment-free interval (TFI) with bortezomib-rituximab (VCR) vs rituximab® in patients (PTS) with relapsed follicular lymphoma (FL)

E KimbyA ScheligaJ MayerFritz OffnerA TeixeiraK KuliczkowskiAM LiberatiCY OkadaD EsseltineP TheocharousE ZhuH Van de VeldeYA ElsayedB Coiffier

2010

Anti-CD22 immunoconjugate inotuzumab ozogamicin (CMC-544) + rituximab: clinical activity in patients with relapsed/refractory follicular or 'aggressive' lymphoma

G VerhoefN DangM SmithFritz OffnerP JohnsonA RohatinerJ KaufmanE GineB CoiffierM CzuczmanJ ForanS DurrantS HuaE VandendriesJ BoniL Fayad

Aspiration pneumonia : an underestimated cause of severe respiratory failure in patients with haematological malignancies and severe oral mucositis?

Nicolaas De NeveDominique BenoitPieter DepuydtFritz OffnerJOKE NOLLETLucien NoensJohan Decruyenaere

A1 Journal Article in ACTA CLINICA BELGICA

Characterization of the unfolded protein response by pharmacological agents in lymphoid malignancies

Sofie LustFritz OffnerMarc Bracke

Impact of organ dysfunction on mortality in ICU patients with hematologic malignancies

Dominique VandijckPieter DepuydtFritz OffnerJOKE NOLLETRenaat PelemanEVA STEELLucien NoensJohan DecruyenaereDominique Benoit

A1 Journal Article in INTENSIVE CARE MEDICINE

Rituximab maintenance for 2-years significantly improves the outcome of patients with untreated high tumor burden follicular lymphoma after response to immunochemotherapy: results of the PRIMA study

G SallesJ CatalanoP FeugierFritz OffnerR BouabdallahD CaballeroP BriceLM PedersenC HaiounD BeladaA DelmerD SimpsonH TillyS LeppaP SoubeyranA HagenbeekO CasasnovasI TaninC FermeMG Da SilvaC SebbanR PettengellJ EstellG MiloneA SonnetA Lopez-GuillermoJ SeymourL Xerri

The flavonoid tangeretin activates the unfolded protein response and synergizes with imatinib in the erythroleukemia cell line K562

Sofie LustBarbara VanhoeckeMireille Van GeleJan PhilippéMarc BrackeFritz Offner

A1 Journal Article in MOLECULAR NUTRITION & FOOD RESEARCH

The impact of the initial ventilatory strategy on survival in hematological patients with acute hypoxemic respiratory failure

Pieter DepuydtDominique BenoitCARL ROOSENSFritz OffnerLucien NoensJohan Decruyenaere

A1 Journal Article in JOURNAL OF CRITICAL CARE

2009

Anti-CD22 immunoconjugate inotuzumab ozogamicin (CMC-544) + rituximab: clinical activity including survival in patients with recurrent/refractory follicular or 'aggressive' lymphoma

Nam H DangMitchell R SmithFritz OffnerGregor VerhoefPeter JohnsonAma ZS RohatinerJohathan L KaufmanEva GineBertrand CoiffierMyron S CzuczmanJames ForanSimon DurrantSteven HuaErik R VandendriesLuis Fayad

Chronic Lymphocytic Leukaemia

Jerina BoelensSofie LustBarbara VanhoeckeFritz Offner

A1 Journal Article in ANTICANCER RESEARCH

Phase III Study to Evaluate Temsirolimus Compared With Investigator's Choice Therapy for the Treatment of Relapsed or Refractory Mantle Cell Lymphoma

G HessR HerbrechtJ RomagueraG VerhoefM CrumpC GisselbrechtA LaurellFritz OffnerA StrahsA BerkenblitO HanushevskyJ ClancyB HewesL MooreB Coiffier

A1 Journal Article in JOURNAL OF CLINICAL ONCOLOGY

Steroid effects on ZAP-70 and SYK in relation to apoptosis in poor prognosis chronic lymphocytic leukemia

Jerina BoelensSofie LustFEMKE VAN BOCKSTAELEMireille Van GeleAnn JanssensLara DeryckeBarbara VanhoeckeJan PhilippéMarc BrackeFritz Offner

A1 Journal Article in LEUKEMIA RESEARCH

Xanthohumol activates the proapoptotic arm of the unfolded protein response in chronic lymphocytic leukemia

Sofie LustBarbara VanhoeckeMireille Van GeleJerina BoelensHeleen Van MelckebekeMary KailehWim Vanden BergheGuy HaegemanJan PhilippéMarc BrackeFritz Offner

A1 Journal Article in ANTICANCER RESEARCH

2008

Impact of recent intravenous chemotherapy on outcome in severe sepsis and septic shock patients with hematological malignancies

Dominique VandijckDominique BenoitPieter DepuydtFritz OffnerStijn BlotAnna K Van TilborghJOKE NOLLETEVA STEELLucien NoensJohan Decruyenaere

A1 Journal Article in INTENSIVE CARE MEDICINE

Spectrum of imaging findings in suspected multiple myeloma usisng dynamic contrast-enhanced and whole body MRI

Nele HerregodsKoenraad VerstraeteS Van SnickKOEN GORLEERVANESSA VAN HENDEFritz OffnerLucien Noens

The prenylated chalcone xanthohumol induces unfolded protein response, autophagy, and cell death in breast cancer cells by proteasome inhibition

Barbara VanhoeckeMireille Van GeleWim MartinetAnne-Sophie Vercoutter-EdouartSofie LustDelphine DebruyneDenis De KeukeleireFritz OffnerMarc Bracke

2007

A combined case report of 4 adult patients with hemophagocytic lymphohistiocytosis at the Ghent University Hospital in 2006

Tessa KerreE. SteelA. VantilborghFritz OffnerLucien Noens

B-CLL cells from lymph nodes express higher ZAP-70 levels than B-CLL cells from peripheral blood

Jerina BoelensJan PhilippéFritz Offner

A1 Journal Article in LEUKEMIA RESEARCH

Deguelin inhibits expression of I kappa B alpha protein and induces apoptosis of B-CLL cells in vitro

Ben GeeraertsBarbara VanhoeckeWim Vanden BergheJan PhilippéFritz OffnerDieter Deforce

A1 Journal Article in LEUKEMIA

Levetiracetam and bleeding disorders

Paul BoonR HULHOVENFritz Offner

A1 Journal Article in ACTA NEUROLOGICA BELGICA

Lipoprotein lipase mRNA expression in whole blood is a prognostic marker in B cell chronic lymphocytic leukemia

FEMKE VAN BOCKSTAELEValerie PedeA JANSSENSF CALLEWAERTFritz OffnerBruno VerhasseltJan Philippé

A1 Journal Article in CLINICAL CHEMISTRY

Methylprednisolone downregulates ZAP-70 expression in B-CLL cells in vitro

Jerina BoelensSofie LustAnn JanssensJan PhilippéFritz Offner

Prognostic significance of lipoprotein lipase expression in B-cell chronic lymphocytic leukemia

FEMKE VAN BOCKSTAELEValerie PedeAnn JanssensFilip CallewaertFritz OffnerBruno VerhasseltJan Philippé

The anti-invasive and proapoptotic effect of xanthohumol: potential use in cancer.

Barbara VanhoeckeJERINA BOELENSSofie LustFritz OffnerMarc Bracke

Bookchapter in Beer in Health and Desease Prevention

The endoplasmic reticulum: A target for new anticancer drugs

Jerina BoelensSofie LustFritz OffnerMarc BrackeBarbara Vanhoecke

A1 Journal Article in IN VIVO

Treatment of follicular lymphoma - A review

VANESSA VAN HENDEFritz Offner

A1 Journal Article in ACTA CLINICA BELGICA

Xanthohumol induces in vitro apoptosis in B-CLL cells mediated by non-classical ER stress

Sofie LustBarbara VanhoeckeMireille Van GeleJerina BoelensMary KailehWim Vanden BergheJ PHILLIPESMarc BrackeFritz Offner

Xanthohumol: a new potential proteasome inhibitor that activates the pro-apoptotic arm of the unfolded protein response in B-CLL cells

Sofie LustBarbara VanhoeckeMireille Van GeleJerina BoelensJan PhilippéPetra VinckenMarc BrackeMartine PoelmanFritz Offner

2006

EBV negative Richter's syndrome from a coexistent clone after salvage treatment with alemtuzumab in a CLL patient

A JANSSENSM BERTHP DE PAEPEBruno VerhasseltNadine Van RoyLucien NoensJan PhilippéFritz Offner

A1 Journal Article in AMERICAN JOURNAL OF HEMATOLOGY

Efficacy and safety of rituximab in B-cell post-transplantation lymphoproliferative disorders: results of a prospective multicenter phase 2 study

S CHOQUETV LEBLONDR HERBRECHTG SOCIEAM STOPPAP VANDENBERGHEA FISCHERF MORSCHHAUSERG SALLESW FEREMANSE VILMERMN PERALDIP LANGY LEBRANCHUE OKSENHENDLERJL GARNIERT LAMYA JACCARDA FERRANTFritz OffnerO HERMINEA MOREAUS FAFI-KREMERP MORANDL CHATENOUDN BERRIOT-VAROQUEAUXL BERGOUGNOUXN MILPIED

A1 Journal Article in BLOOD

In vitro screening for synergism of high-linear energy transfer Bi-213-radiotherapy with other therapeutic agents for the treatment of B-Cell chronic lymphocytic leukemia

Katia VandenbulckeHubert ThierensFilip De VosJan PhilippéFritz OffnerAnne JanssensC APOSTOLIDISA MORGENSTERNKlaus BacherVirginie de GelderRudi DierckxG SLEGERS

A1 Journal Article in CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Kolmogorov-Smirnov statistical test for analysis of ZAP-70 expression in B-CLL, compared with quantitative PCR and IgVH mutation status

FEMKE VAN BOCKSTAELEAnn JanssensAnne PietteFilip CallewaertValerie PedeFritz OffnerBruno VerhasseltJan Philippé

A1 Journal Article in CYTOMETRY PART B-CLINICAL CYTOMETRY

Outcome in severely ill patients with hematological malignancies who received intravenous chemotherapy in the intensive care unit

DOMINIQUE BENOITPieter DepuydtKoenraad VandewoudeFritz OffnerTom BoterbergCHANTAL DE COCKLucien NoensAnne JanssensJohan Decruyenaere

A1 Journal Article in INTENSIVE CARE MEDICINE

2005

ACVBP versus CHOP plus radiotherapy for localized aggressive lymphoma

E LEPAGEG GANEMTJ MOLINAG LAURENTM AOUDJANED ASSOULINEB AUDHUYM AZAGURYF BAUDUERE BAUMELOUMA BICHOFFEP BIRONM BLANCD BORDESSOULLEA BOSLYR BOUABDALLAHP BOURQUARDP BRICEN MOUNIERD SIMONC GISSELBRECHTH DOMBRETD CAILLOTO CASANOVASM FLESCHB CHAUFFERTGP CASSUTOS CASTAIGNEB CHRISTIANB COIFFIERP COLING PINON-NETTERT CONROYH CUREA DELMERV DELWAILA DEVIDASF DREYFUSG DUPONTJC EISENMANNM FABBROG FILLETC FURCHARTJ GABARREM GABEZM GAUTIERC HAIOUNM DIVINEK BELHADJF REYESR HERBRECHTO HERMINEB VARETM JANVIERE JOURDAND KAMIONERY KERNEISF MORVANP LEDERLINS LEFORTG LEPEUJP LOTZD MACHOVERF MARECHALG MARITC MARTINS MEYERP MORELB DUPRIEZJN MUNCKC FERMEP CARDEFritz OffnerJM PAVLOVITCHI PLANTIERH ORFEUVREPY PEAUDAM PENYC PLATINIM PULLIKB QUESNELF MORSCHAUSHERO REMANM LEPORRIERC ROSEP RODONJF ROSSIB SALLESD SCHLAIFERF HUGUETA HUYNC SEBBANM SIMONP SOLAL-CELIGNYJJ SOTTOC SOUSSAINC ALLARDG TERTIANH TILLYA THYSSC TRAULLEP TRAVADEA VAN HOOFJM ZINIJ BRIEREJ DIEBOLDB FABIANIP GAULARDC GUETTIERT MOLINAT PETRELLA

A1 Journal Article in NEW ENGLAND JOURNAL OF MEDICINE

Acute ulcerative colitis during successful interferon/ribavirin treatment for chronic hepatitis

R. SprengerM. SagmeisterFritz Offner

A1 Journal Article in GUT

Baseline nucleophosmin status in mutated(M) versus unmutated (U) immunoglobulin B-CLL is a nuclear reflection of different signal transduction physiology

JENS BOELENSW. Van den BergheGuy HaegemanAnne JanssensJan PhilippéFritz Offner

Baseline nucleophosmin status in mutated(M) versus unmutated(U) immunoglobulin B-CLL is a nuclear reflection of different signal transduction physiology

Jerina BoelensWim Vanden BergheGuy HaegemanAnne JanssensJan PhilippéFritz Offner

CVP chemotherapy plus rituximab compared with CVP as first-line treatment for advanced follicular lymphoma

R MARCUSK IMRIEA BELCHD CUNNINGHAME FLORESJ CATALANOP SOLAL-CELIGNYFritz OffnerJ WALEWSKIJ RAPOSOA JACKP SMITH

A1 Journal Article in BLOOD

CVP plus rituximab compared to CVP alone in previously untreated patients with follicular lymphoma: Impact of baseline prognostic factors

K IMRIEA BELCHR PETTENGELLA RUEDAJ MCKENDRICKP SOLAL-CELIGNYFritz OffnerI BENCE-BUCKLERJ WALEWSKIJ RAPOSOR MARCUS

Correlation of ZAP-70 analysed by RT-PCR with ZAP-70 determined by flow cytometry and with IgVH mutational status in B-CLL

Jan PhilippéFEMKE VAN BOCKSTAELEFilip CallewaertA JANSSENSFritz OffnerBruno Verhasselt

Deguelin, a PI3K/Akt inhibitor induceds apoptotic killing of B-CLL cells in vitro

Ben GeeraertsFritz OffnerDieter Deforce

Documented and clinically suspected bacterial infection precipitating intensive care unit admission in patients with hematological malignancies: impact on outcome

DOMINIQUE BENOITPieter DepuydtRenaat PelemanFritz OffnerKoenraad VandewoudeDirk VogelaersStijn BlotLucien NoensFrancis ColardynJohan Decruyenaere

A1 Journal Article in INTENSIVE CARE MEDICINE

Mabthera (Rituximab) plus CVP chemotherapy for first-line treatment of stage III/IV follicular non-Hodgkin's lymphoma (NHL): Confirmed efficacy with longer follow-up

P SOLAL-CELIGNYK IMRIEA BELCHKS ROBINSOND CUNNINGHAMA RUEDAJ CATALANOFritz OffnerJ WALEWSKIJ RAPOSOP SMITHR MARCUS

Old and new insights into the mechanisms of action of two nucleoside analogs active in lymphoid malignancies: fludarabine and cladribine (Review)

E VAN DEN NESTES CARDOENFritz OffnerF BONTEMPS

A1 Journal Article in INTERNATIONAL JOURNAL OF ONCOLOGY

Outcome in critically ill medical patients treated with renal replacement therapy for acute renal failure: comparison between patients with and those without haematological malignancies

DOMINIQUE BENOITEric HostePieter DepuydtFritz OffnerNorbert LameireKoenraad VandewoudeAnnemieke DhondtLucien NoensJohan Decruyenaere

A1 Journal Article in NEPHROLOGY DIALYSIS TRANSPLANTATION

Prognostische factoren bij B-CLL

Jan PhilippéANN JANSSENSFritz Offner

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

VH-gene usage is of prognostic value in B-cell chronic lymphocytic leukemia

FEMKE VAN BOCKSTAELEKaatje SmitsFritz OffnerAnne JanssensJan PhilippéBruno Verhasselt

Xanthohumol induces apoptosis in B-CLL mediated by caspase 9 following downregulation of bcL-xL and mcl-1

Barbara VanhoeckeSofie LustAnne JanssensJan PhilippéMarc BrackeFritz Offner

Xanthohumol kills B-chronic lymphocytic leukemia cells by an apoptotic mechanism

Sofie LustBarbara VanhoeckeAnne JanssensJan PhilippéMarc BrackeFritz Offner

A1 Journal Article in MOLECULAR NUTRITION & FOOD RESEARCH

2004

All aggressive lymphoma subtypes do not share similar outcome after front-line autotransplantation: a matched-control analysis by the Groupe d'Etude des Lymphomes de l'Adulte (GELA)

N MOUNIERC GISSELBRECHTJ BRIEREC HAIOUNP FEUGIERFritz OffnerC RECHERA STAMATOULLASF MORSCHHAUSERM MACROC THIEBLEMONTA SONETB FABIANIF REYES

A1 Journal Article in ANNALS OF ONCOLOGY

CXCL-12 induces prolonged erk-phosphorylation in Zap-70 positive B-CLL

Sofie LustJerina BoelensANN JANSSENSJan PhilippéMarc BrackeFritz Offner

Correlation of ZAP-70 analysed by flow cytometry with IgVH mutational status in B-CLL

Jan PhilippéB LEUSAnne PietteFEMKE VAN BOCKSTAELEANN JANSSENSFritz Offner

Importance of receptor density in alpha radioimmunotherapy in B cell malignancies: an in-vitro study

Katia VandenbulckeHubert ThierensFritz OffnerAnne JanssensVirginie de GelderKlaus BacherJan PhilippéFilip De VosRudi DierckxC APOSTOLIDISA MORGENSTERNGuido Slegers

A1 Journal Article in NUCLEAR MEDICINE COMMUNICATIONS

Liposomal nystatin in patients with invasive aspergillosis refractory to or intolerant of amphotericin B

Fritz OffnerV KRCMERYM BOOGAERTSC DOYEND ENGELHARDP RIBAUDC CORDONNIERB DE PAUWS DURRANTJP MARIEP MOREAUH GUIOTG SAMONISR SYLVESTERR HERBRECHT

A1 Journal Article in ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Prognostic factors in patients with aggressive non-Hodgkin's lymphoma treated by front-line autotransplantation after complete remission: A cohort study by the Groupe d'Etude des Lymphomes de l'Adulte

N MOUNIERC GISSELBRECHTJ BRIEREC HAIOUNP FEUGIERFritz OffnerC RECHERA STAMATOULLASF MORSCHHAUSERM MACROC THIEBLEMONTA SONETB FABIANIF REYES

A1 Journal Article in JOURNAL OF CLINICAL ONCOLOGY

Tangeretin synergizes with imatinib in inhibiting growth of bcr-abl positive K562 Erythroleukemia cells in an Erk-dependent way

Sofie LustBarbara VanhoeckeMarc BrackeFritz Offner

Targeted alpha radiation and gamma rays induce distinct and mutation status specific transcriptional responses in human leukemic lymphocytes

S MARTINR KRONENWETTK VANDENBUICKEFritz OffnerS KLISZEWSKIC APOSTOLIDISA MORGENSTERNU STEIDLS RASCHKEF NEUMANNJan PhilippéG SLEGERSR HAAS

The restricted V-H-gene usage is of prognostic value in B-cell chronic lymphocytic leukemia

Jan PhilippéFEMKE VAN BOCKSTAELEKaatje SmitsFritz OffnerBruno VerhasseltANN JANSSENS

VH-gene usage is of prognostic value in CLL

Jan PhilippéANN JANSSENSKaatje SmitsILSE MOLLETFritz Offner

2003

Alpha-immunotherapy compared to external gamma irradiation, cold antibody and chemotherapy in B-CLL in vitro: Correlation with clinical chemotherapy sensitivity

K VANDENBULCKEFritz OffnerFilip De VosA JANSSENST NIKULAC APOSTOLIDESR MOLINETW JANSSENSHubert ThierensRudi DierckxGuido SlegersJan Philippé

An international multi-centre, randomized, open-label, phase III trial comparing rituximab added to CVP chemotherapy to CVP chemotherapy alone in untreated stage III/IV follicular non-Hodgkins lymphoma

R MARCUSK IMRIEA BELCHD CUNNINGHAME FLORESJ CATALANOP SOLAL-CELIGNYFritz OffnerJ WALEWSKIJ RAPOSOA JACKP SMITH

Cold and alpha-conjugated anti-CD20 induce different in vitro apoptosis reponses in B-chronic lymphocytic leukaemia (B-CLL)and splenic lymphoma with villous lymphocytes (SLVL)

K VANDENBULCKEFritz OffnerGuido SlegersFilip De VosVirginie de GelderA WILLEMSS MARTINR MOLINETC APOSTOLIDISTK NIKULAW JANSSENSA JANSENNSHubert ThierensRudi DierckxJan Philippé

Cytotoxicity of gamma versus alpha radiation in lymphoid cell lines with defects in the TNF receptor family mediated and NF-kappa B related apoptotic and anti-apoptotic pathways

KJ VANDENBULCKEK VANDENBULCKERudi BeyaertC APOSTOLIDEST NIKULAW JANSSENSANN JANSSENSVirginie de GelderAnnick WillemsGuido SlegersHubert ThierensRudi DierckxFilip De VosJan PhilippéFritz Offner

In vitro evaluation of Bi-213-rituximab versus external gamma irradiation for the treatment of B-CLL patients: Relative biological efficacy with respect to apoptosis induction and chromosomal damage by the micronucleus assay

K VANDENBULCKEFilip De VosFritz OffnerJan PhilippéC APOSTOLIDISR MOLINETTK NIKULAKlaus BacherVirginie de GelderAnne VralChristophe LahorteHubert ThierensRudi DierckxGuido Slegers

In vitro evaluation of Bi-213-rituximab versus external gamma irradiation for the treatment of B-CLL patients: relative biological efficacy with respect to apoptosis induction and chromosomal damage

Katia VandenbulckeFILIP DE VOSFritz OffnerJan PhilippéC APOSTOLIDISR MOLINETTK NIKULAKlaus BacherV DE GELDERAnne VralChristophe LahorteHubert ThierensRudi DierckxGuido Slegers

A1 Journal Article in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Molecular mechanisms of alpha-particles-induced cytotoxicity in human leukemic cells as revealed by gene expression profiling

S MARTINR KRONENWETTK VANDENBULCKEFritz OffnerS KLISZEWSKIC APOSTOLIDISR CARLOSW JANSSENSM LEROYT NIKULAJan PhilippéR HAAS

Prognostic factors for aggressive lymphoma patients treated with front-line autotransplantation after complete remission: A cohort study on 330 patients

N MOUNIERC GISSELBRECHTJ BRIEREC HAIOUNP FEUGIERFritz OffnerC RECHERA STAMATOULLASF MORSCHHAUSERM MACROC THIEBLEMONTA BOSLYB FABIANIF REYES

Radio-immunotherapie bij B-CLL-NHL: een update

F GEMMELF DE WINTERK VAN LAEREV RENARDB BRANSRudi DierckxFritz Offner

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

2002

Adapted NOD/SCID model supports development of phenotypically and functionally mature T cells from human umbilical cord blood CD34(+) cells.

Tessa KerreG DE SMETM DE SMEDTA ZIPPELIUSMJ PITTETAW LANGERAKJ DE BOSSCHERFritz OffnerBart VandekerckhoveJean Plum

A1 Journal Article in BLOOD

Alpha-immunotherapy compared to gamma-radiation, cold antibody, and chemotherapy in B-CLL in vitro: Correlation with clinical chemosensitivity

Fritz OffnerKL VANDENBULCKEF DEVOSANN JANSSENSJan PhilippéGuido SlegersHubert ThierensT NIKULAC APOSTOLIDESW JANSSENSRudi Dierckx

Cytokine deprivation improves the homing of long-term cultured human hematopoietic stem cells after intravenous injection into NOD/SCID mice

Tessa KerreKatrien VanheusdenFritz OffnerJean PlumBart Vandekerckhove

Cytokine deprivation improves the homing of long-term cultured human hematopoietic stem cells after transplantation int NOD/SCID mice

Tessa KerreBart VandekerckhoveFritz OffnerJean Plum

Definitions of infectious diseases and complications after stem cell transplant

C CORDONNIERD ENGELHARDP LJUNGMANA DEKKERP DONNELLYH EINSELEE HOLLERH LINKA LOCASCIULLIR MARTINOFritz OffnerP REUSSERM ROVIRAA ULLMANNK WARD

Efficacy and safety of Rituximab in B-cell post transplantation lymphoproliferative disorders (B-PTLD): Preliminary results of a multicenter, open label, phase II trial (M39037 TRIAL)

S CHOQUETR HERBRECHTG SOCIEAM STOPPAP VANDENBERGHEW FEREMENSA FISCHERF MORSCHAUSERG SALLESE VILMERJL GARNIERA JACCARDT LAMYP LANGY LEBRANCHUFritz OffnerE OKSENHENDLERK IMADALOUS FAFIA MOREAUV LEBLONDN MILPIED

Long term culture of human hematopoietic stem cells influence on homing, organ selectivity, survival and proliferation early after transplantation into NOD/SCID mice

Tessa KerreBart VandekerckhoveFritz OffnerJean Plum

Radioimmunotherapie bij het B-cel Non-hodgkin Lymfoom: een update

F GEMMELF DE WINTERKoenraad Van LaereB BRANSV RENARDRudi DierckxFritz Offner

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

2001

An adapted NOD/SCID model supports the development of phenotypically and functionally mature T cells from human umbilical cord blood CD34(+) cells

Tessa KerreBart VandekerckhoveFritz OffnerJean Plum

Both CD34(+)38(+) and CD34(+)38(-) cells home specifically to the bone marrow of NOD/LtSZ scid/scid mice but show different kinetics in expansion.

Tessa KerreG DE SMETM DE SMEDTFritz OffnerJ DE BOSSCHERJean PlumBart Vandekerckhove

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Comparison of in vitro apoptosis induction by alpha-irradiation versus gamma-irradiation in B-CLL

Fritz OffnerFilip De VosK VANDENBULCKEANN JANSSENSR MOLINETC APOSTOLIDISW JANSSENST NIKULAChristophe LahorteB BRANSGuido SlegersHubert ThierensRudi DierckxJan Philippé

Essentiële thrombocytose.

Fritz OffnerAnn JanssensJ VERMEIREN

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

The behavior of long-term cultured human hematopoietic stem cells early after transplantation into NOD/SCID mice provides explanations for their impaired long-term engraftment in this model

Tessa KerreBart VandekerckhoveFritz OffnerJean Plum

2000

Bone marrow necrosis.

Ann JanssensFritz OffnerWerner Van Hove

A1 Journal Article in CANCER

Both human CD34(+)38(+) and CD34(+)38(-) cells home specifically to the bone marrow, but show different kinetics in take and proliferation

Tessa KerreG DE SMETMagda De SmedtFritz OffnerJean PlumBart Vandekerckhove

CEA elevation in chronic granulocytic leukemia.

M WITHOFSFritz OffnerP DE PAEPEMarleen Praet

A1 Journal Article in BRITISH JOURNAL OF HAEMATOLOGY

Generation of T cells from adult human hematopoietic stem cells and progenitors in a fetal thymic organ culture system: stimulation by tumor necrosis factor-alpha.

S WEEKXHW SNOECKFritz OffnerM DE SMEDTDR VAN BOCKSTAELEG NIJSM LENJOUA MOULIJNI RODRIGUSZN BERNEMANJean Plum

A1 Journal Article in BLOOD

1999

A single step real-time quantitative RT-PCR reaction for detection of the BCR/ABL fusion product

H VAN LIMBERENL VAN DE LOCHTBruce PoppeAnne De PaepeFritz OffnerE MENSINKFranki Speleman

Bone marrow CD34+ cells generate fewer T cells in vitro with increasing age and following chemotherapy

Fritz OffnerTessa KerreMagda De SmedtJean Plum

A1 Journal Article in BRITISH JOURNAL OF HAEMATOLOGY

Chromosome 7 short arm deletions and disease progression in CML

Bruce PoppeH VAN LIMBERGENANN JANSSENSNadine Van RoyBarbara De MoerlooseJ PHILLIPEAnne De PaepeFritz OffnerFranki Speleman

Identification of a novel CBFB/MYH11 fusion in a patient with AML-M1 and a t(16;16)(p13;q22)

H VAN LIMBERGENB VAN DER REIJDENBruce PoppeFritz OffnerNadine Van RoyH DAUWERSEAnne De PaepeFranki Speleman

In vitro intrathymic differentiation kinetics of human fetal liver CD34(+)CD38(-) progenitors reveals a phenotypically defined dendritic/T-NK precursor split

Jean PlumMagda De SmedtBruno VerhasseltFritz OffnerTessa KerreD VANHECKEGeorges LeclercqBart Vandekerckhove

A1 Journal Article in JOURNAL OF IMMUNOLOGY

1998

An EORTC multicentre prospective survey of invasive aspergillosis in haematological patients: Diagnosis and therapeutic outcome.

DW DENNINGA MARINUSJ COHEND SPENCER HERBRECHTL PAGANOC KIBBLERV KCRMERYFritz OffnerC CORDONNIERU JEHNM ELLISL COLLETTER SYLVESTER

A1 Journal Article in JOURNAL OF INFECTION

Anémie bij de kankerpatiënt.

T KERREFritz OffnerWerner Van Hove

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

De ziekte van Waldenström.

A MAENHOUTFritz Offner

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Impact of previous aspergillosis on the outcome of bone marrow transplantation.

Fritz OffnerC CORDONNIERP LJUNGMANHG PRENTICED ENGELHARDDirk De BacquerF MEUNIERB DE PAUW

A1 Journal Article in CLINICAL INFECTIOUS DISEASES

Risk mortality related to duration and severity of neutropenia following bone marrow transplantation

A2 Journal Article in TOPICS ON SUPPORTIVE CARE IN ONCOLOGY

The Hermansky-Pudlack syndrome

A BRANDTFritz OffnerJ QUATACKERJ PHILIPPEFrançoise Meire

A2 Journal Article in Bull. Soc. Belge Ophtalmol., 267, 99-105

The role of interleukin-7 in early T-cell development.

Fritz OffnerJean Plum

A1 Journal Article in LEUKEMIA & LYMPHOMA

Two cases of disseminated mucormycosis in patients with hematological malignancies and literature review.

I CUVELIERDirk VogelaersRenaat PelemanDominique BenoitV VAN MARCKFritz OffnerK VANDEWOUDEFrancis Colardyn

A1 Journal Article in EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

1997

Hematopoietic growth factors in cancer patients with invasive fungal infections.

A1 Journal Article in EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Phenotypic and functional maturation of TCR gamma delta cells in the human thymus.

Fritz OffnerKatrien Van BenedenV DEBACKERDominique VanheckeBart VandekerckhoveJean PlumGeorges Leclercq

A1 Journal Article in JOURNAL OF IMMUNOLOGY

The use of hematopoietic growth factors in cancer patients: indications and impact on invasive fungal infections

A2 Journal Article in Eur. J. Clin. Microbiol. Infect, dis., 16

1996

Acute lymphoblastic leukemia as part of the retinoblastoma inherited cancer syndrome

J VAN DROOGENBROECKLucien NoensA JANSSENSFritz OffnerWerner Van HoveFranki Speleman

A2 Journal Article in Belg. Hematol. Soc, pp. 90

Idioathische trombocytopenische purpura bij volwassenen.

A JANSSENSFritz OffnerLucien NoensWerner Van Hove

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Mortality hazard functions as related to neutropenia at different times after marrow transplantation

Fritz OffnerG SchochLD FisherB TorokStorbPJ Martin

A1 Journal Article in BLOOD

Prognostic markers in septic shock

Jan PhilippéFritz OffnerGaston BaeleGeert Leroux-Roels

Splenectomy does not influence dose intensitivity of chemotherapy in advanced Hodgkin's disease

Fritz OffnerR PIENSAM GOBERTN COPPENSLucien NoensWerner Van Hove

A2 Journal Article in Belg. Hematol. Soc, p 99

The use of hematopoietic growth factors in cancer patients: indications and impact on invasive fungal infections

A2 Journal Article in Europ. J. Clin. Microbiology & Infect. Dis., 15. Suppl. 1, S1-S8

1995

Aspergillosis prior to bone marrow transplantation : is it a contraindication to BMT?

C CordonnierJ BeauneFritz OffnerA MarinusP LjungmanF Meunier

A1 Journal Article in BONE MARROW TRANSPLANTATION

Behandeling van chronische myeloïde leukemie.

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Chronisch lymfatische leukemie.

Fritz OffnerA JANSSENS

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Intensive care treatment for patients with hematological diseases

K VANDEWOUDEA KOCHDirk VogelaersLucien NoensFritz OffnerF COLARDYN

A2 Journal Article in Belg. Hematol. Soc., p. 108

Retrospective analysis of different therapeutic options in treating adult ITP-patients

A JANSSENSFritz OffnerJ VAN DROOGENBROECKLucien NoensWerner Van Hove

A2 Journal Article in Belg. Hematol. Soc., p. 135

Sepsis and other severe complications of hematological disease in a medical intensive care unit

K VANDEWOUDEA KOCHDirk VogelaersFritz OffnerLucien NoensFrancis Colardyn

1994

MORTALITY HAZARD AS RELATED TO THE DURATION OF NEUTROPENIA AFTER MARROW TRANSPLANTATION

Fritz OffnerG SCHOCHL FISHERP MARTIN

RELATIONSHIP OF SERUM CYTOKINES (TNF-ALPHA, IL-1-BETA, IFN-GAMMA AND INFLAMMATION MARKERS (NEOPTERIN, BETA-2-MICROGLOBULIN, C-REACTIVE PROTEIN) TO TRANSPLANT-RELATED COMPLICATIONS AND IMMUNOGLOBULIN PROPHYLAXIS FOLLOWING ALLOGENEIC MARROW TRANSPLANTATION

KM SULLIVANFritz OffnerM HEROLDM MORIC HUBERD NIEDERWIESERFR APPELBAUMR STORB

1992

GRANULOCYTE ELASTASE, TUMOR-NECROSIS-FACTOR-ALPHA AND UROKINASE LEVELS AS PROGNOSTIC MARKERS IN SEVERE INFECTION.

Jan PhilippéG DOOIJEWAARDFritz OffnerP TURIONGaston BaeleGeert Leroux-Roels

A1 Journal Article in THROMBOSIS AND HAEMOSTASIS

INCIDENCE AND CLINICAL CHARACTERISTICS OF PRIMARY GRAFT FAILURE

Fritz OffnerB SANDMAIERB TOROKSTORBP MARTIN

The relationship between TNF-a and liver failure

Jan PhilippéFritz OffnerGeert Leroux-Roels

A2 Journal Article in Eur. Cytokine Netw., 3, p. 253

1991

Analysis of whole-arm translocations in malignant blood cells by nonisotopic in situ hybridization

Franki SpelemanK MangelschotsM VercruyssenP Dal CinA AventinFritz OffnerGenevieve LaureysH Van den BergheJuliaan Leroy

A1 Journal Article in CYTOGENETICS AND CELL GENETICS

Extra translocation t(lq9p) is a prognostic indicator in myeloproliferative disorders

G RegecambrinFranki SpelemanS KerimP ScaravaglioF CarozziP DalcinJL MichauxFritz OffnerG SaglioH Vandenberghe

A1 Journal Article in LEUKEMIA

Fibrinolysis and coagulation in patients with infectious disease and sepsis

Jan PhilippéFritz OffnerPJ De ClerckGeert Leroux-RoelsDirk VogelaersGaston BaeleD Collen

A1 Journal Article in THROMBOSIS AND HAEMOSTASIS

Serum TNF levels in patients with infectious disease and septic shock

Fritz OffnerJan PhilippéDirk VogelaersGaston BaeleFrancis ColardynM BaudrihayeAlex VermeulenGeert Leroux-Roels

Bookchapter in The year book of surgery 1991

THYMOMA - A CLINICOPATHOLOGICAL COMPARATIVE-STUDY OF 25 CASES

Fritz OffnerJ VALLAEYSHendrik RoelsM VANDERSTRAETEN

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

1990

In-vitro production of cytokines in blood

Geert Leroux-RoelsJan PhilippéFritz OffnerAlex Vermeulen

A1 Journal Article in LANCET

Serum tumor necrosis factor levels in patients with infectious disease and septic shock

Fritz OffnerJan PhilippéDirk VogelaersFrancis ColardynGaston BaeleM BaudrihayeAlex VermeulenGeert Leroux-Roels

A1 Journal Article in JOURNAL OF LABORATORY AND CLINICAL MEDICINE

Wegener granulomatosis : a review of 5 cases

N VeysFritz OffnerN Lameire

A1 Journal Article in ACTA CLINICA BELGICA

1989

GM-CSF and G-CSF in hematology and oncology

Fritz OffnerW Vanhove

A1 Journal Article in ACTA CLINICA BELGICA

1988

Influence of blood-collecting systems on concentrations of tumor necrosis factor in serum and plasma

Geert Leroux-RoelsFritz OffnerJan PhilippéAlex Vermeulen

A1 Journal Article in CLINICAL CHEMISTRY

Onderzoek naar een aantal prognostische markers bij patiënten met zeer ernstige infectie of sepsis. 8e Amstol Symposium, Amsterdam, 25/9/1992, werkboek p. 3.4.

Jan PhilippéG DOOUEWAARDFritz OffnerP TURIONGaston BaeleGeert Leroux-Roels