Research Explorer

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Researcher

Frans Van Roy

Awards & Distinctions

315 Results

2022

Innovative mouse models for the tumor suppressor activity of protocadherin-10 isoforms

Irene KleinbergerEllen SandersKatrien StaesMarleen Van TroysShinji HiranoTino HochepiedKelly LemeireLiesbet MartensChristophe AmpeFrans Van Roy

A1 Journal Article in BMC CANCER

Modifying PCDH19 levels affects cortical interneuron migration

Anna PanchoManuela D. D. MitsogiannisTania AertsMarco Dalla VecchiaLena K. K. EbertLieve GeenenLut NoterdaemeRia VanlaerAnne StulensPaco Hulpiau et al.

A1 Journal Article in FRONTIERS IN NEUROSCIENCE

Plakophilin3 loss leads to increased adenoma formation and rectal prolapse in APCmin mice

Rahul RaghavanNavami KoyandeRohit BeherNeha ChetlangiaMukda RamadwarShital PawadeRahul ThoratJolanda van HengelTetyana SklyarovaFrans Van Roy et al.

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

2020

Neural defects caused by total and Wnt1-Cre mediated ablation of p120ctn in mice

Tim PietersEllen SandersHuiyu TianJolanda van HengelFrans Van Roy

A1 Journal Article in BMC DEVELOPMENTAL BIOLOGY

Unraveling the ultrastructural details of αT‐catenin‐deficient cell‐cell contacts between heart muscle cells by the use of FIB‐SEM

Bieke VanslembrouckAnna KremerFrans Van RoySaskia LippensJolanda van Hengel

A1 Journal Article in JOURNAL OF MICROSCOPY

2019

A new mouse model to study the role of ectopic Nanos3 expression in cancer

Vanessa AndriesEvi De KeuckelaereKatrien StaesTino HochepiedJoachim TaminauKelly LemeirePhilippe BirembautGeert BerxFrans Van Roy

A1 Journal Article in BMC CANCER

Armc8 is a evolutionarily conserved armadillo protein involved in cell-cell adhesion complexes through multiple molecular interactions

Ismail Sahin GülPaco HulpiauEllen SandersFrans Van RoyJolanda van Hengel

A1 Journal Article in BIOSCIENCE REPORTS

N-cadherin stabilises neural identity by dampening anti-neural signals

Karolina PunovuoriRosa P MiguelesMattias MalagutiGuillaume BlinKenneth G MacleodNeil O CarragherTim PietersFrans Van RoyMarc P StemmlerSally Lowell

A1 Journal Article in DEVELOPMENT

Optimized protocol for the three-dimensional visualization and reconstruction of intercellular junctions in cardiac muscle using SBF-SEM and FIB-SEM

Bieke VanslembrouckAnna KremerBenjamin PavieFrans Van RoySaskia LippensJolanda van Hengel

2018

3-D reconstructions of intercellular junctions of the intercalated disc and their connection to complexes of the excitation-contraction coupling unit of cardiomyocytes

Bieke VanslembrouckAnna KremerBenjamin PavieFrans Van RoySaskia LippensJolanda van Hengel

Ancient origin of the CARD-coiled coil/Bcl10/MALT1-like paracaspase signaling complex indicates unknown critical functions

Jens StaalYasmine DriegeMira HaegmanAlice BorghiPaco HulpiauLaurens LievensIsmail Sahin GülSrividhya Sundararaman IyerAmanda GonçalvesIneke Dhondt et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Cadherin repertoires in lower metazoans : Trichoplax adhaerens and Nematostella vectensis

Srividhya Sundararaman IyerFrans Van RoyKris Vleminckx

Bookchapter in Encyclopedia of signaling molecules

Changing the name of the NBPF/DUF1220 domain to the Olduvai domain

James M SikelaFrans Van Roy

A2 Journal Article in F1000RESEARCH

GC content of Early Metazoan genes and its impact on gene expression levels in mammalian cell lines

Ismail Sahin GülJens StaalPaco HulpiauEvi De KeuckelaereKai KammTom DerooEllen SandersKatrien StaesYasmine DriegeYvan Saeys et al.

A1 Journal Article in GENOME BIOLOGY AND EVOLUTION

Nanos genes and their role in development and beyond

Evi De KeuckelaerePaco HulpiauYvan SaeysGeert BerxFrans Van Roy

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

The role of Nanos3 in tumor progression

Evi De KeuckelaereFrans Van RoyGeert Berx

Three-dimensional reconstruction of the intercalated disc including the intercellular junctions by applying volume scanning electron microscopy

Bieke VanslembrouckAnna KremerBenjamin PavieFrans Van RoySaskia LippensJolanda van Hengel

A1 Journal Article in HISTOCHEMISTRY AND CELL BIOLOGY

Three-dimensional reconstruction of the intercalated disc including the intercellular junctions by applying volume scanning electron microscopy

Bieke VanslembrouckAnna KremerBenjamin PavieFrans Van RoySaskia LippensJolanda van Hengel

2017

Evolution and diversity of cadherins and catenins

Ismail Sahin GülPaco HulpiauYvan SaeysFrans Van Roy

A1 Journal Article in EXPERIMENTAL CELL RESEARCH

Metazoan evolution of the armadillo repeat superfamily

Ismail Sahin GülPaco HulpiauYvan SaeysFrans Van Roy

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Structure-function studies in mouse embryonic stem cells using recombinase-mediated cassette exchange

Tim PietersLieven HaenebalckeKenneth BruneelNiels VandammeTino HochepiedJolanda van HengelDagmar WirthGeert BerxJody J HaighFrans Van Roy et al.

A1 Journal Article in JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

2016

Evolution of cadherins and associated catenins

Paco HulpiauIsmail Sahin GülFrans Van Roy

Bookchapter in The cadherin superfamily : key regulators of animal development and physiology

Formin is associated with left-right asymmetry in the pond snail and the frog

Angus DavisonGary S McDowellJennifer M HoldenHarriet F JohnsonGeorgios D KoutsovoulosM Maureen LiuPaco HulpiauFrans Van RoyChristopher M WadeRuby Banerjee et al.

A1 Journal Article in CURRENT BIOLOGY

Identification and functional analysis of molecular interaction partners of δ-protocadherin family members with putative roles in cancer

Eleonora BilliFrans Van RoyJan Tavernier

Inactivation of p120 catenin in mice disturbs intrahepatic bile duct development and aggravates liver carcinogenesis

Jolanda van HengelCeline Van den BroekeTim PietersLouis LibbrechtIlse HofmannFrans Van Roy

A1 Journal Article in EUROPEAN JOURNAL OF CELL BIOLOGY

Molecular evolution of the armadillo repeat superfamily and characterization of representative members in key model organisms

Ismail Sahin GülFrans Van RoyJolanda van Hengel

Protocadherin-1 localization and cell-adhesion function in airway epithelial cells in asthma

Grissel Faura TellezBrigitte WM WillemseUilke BrouwerSusan Nijboer-BrinksmaKarl VandepoeleJacobien A NoordhoekIrene HeijinkMaaike de VriesNatalie P SmithersDirkje S Postma et al.

A1 Journal Article in PLOS ONE

p120 Catenin-mediated stabilization of E-cadherin is essential for primitive endoderm specification

Tim PietersSteven GoossensLieven HaenebalckeVanessa AndriesAgata StryjewskaRiet De RyckeKelly LemeireTino HochepiedDanny HuylebroeckGeert Berx et al.

A1 Journal Article in PLOS GENETICS

αT-catenin in restricted brain cell types and its potential connection to autism

Stephen Sai FolmsbeeDouglas R WilcoxKoen TybergheinPieter De BleserWarren G TourtellotteJolanda van HengelFrans Van RoyCara J Gottardi

A2 Journal Article in JOURNAL OF MOLECULAR PSYCHIATRY

2015

Alpha-catenins control cardiomyocyte proliferation by regulating Yap activity

Jifen LiErhe GaoAlexia ViteRoslyn YiLudovic GomezSteven GoossensFrans Van RoyGlenn L Radice

A1 Journal Article in CIRCULATION RESEARCH

Hematopoietic plakophilin-3 regulates acute tissue-specific and systemic inflammation in mice

Tatyana SklyarovaJolanda van HengelElien Van WonterghemClaude LibertFrans Van RoyRoosmarijn Vandenbroucke

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

NBPF1, a tumor suppressor candidate in neuroblastoma, exerts growth inhibitory effects by inducing a G1 cell cycle arrest

Vanessa AndriesKarl VandepoeleKatrien StaesGeert BerxPieter BogaertGert Van IsterdaelDaisy GinnebergeEef ParthoensJonathan VandenbusscheKris Gevaert et al.

A1 Journal Article in BMC CANCER

Protocadherin-1 binds to SMAD3 and suppresses TGF-β1-induced gene transcription

Grissel Faura TellezKarl VandepoeleUilke BrouwerHenk KoningRobin M EldermanTillie-Louise HackettBrigitte WM WillemseJohn HollowayFrans Van RoyGerard H Koppelman et al.

A1 Journal Article in AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

TALEN mediated mutation of apc and β-catenin in Xenopus tropicalis as powerful models for Wnt driven cancer and Familial Adenomatous Polyposis (FAP)

Tom Van NieuwenhuysenThomas NaertDavid CreytensFrans Van RoyKris Vleminckx

TALEN-mediated apc mutation in Xenopus tropicalis phenocopies familial adenomatous polyposis

Tom Van NieuwenhuysenThomas NaertHong Tran ThiGriet Van ImschootSarah GeursEllen SandersDavid CreytensFrans Van RoyKris Vleminckx

A2 Journal Article in ONCOSCIENCE

The cardiac protein αT-catenin contributes to chemical-induced asthma

Stephen Sal FolmsbeeLuisa Morales-NebredaJolanda van HengelKoen TybergheinFrans Van RoyGR Scott BudingerPaul J BryceCara J Gottardi

A1 Journal Article in AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The human NANOS3 gene contributes to lung tumour invasion by inducing epithelial-mesenchymal transition

Simon GreletVanessa AndriesMyriam PoletteChristine GillesKatrien StaesAnne-Pascaline MartinClaire KileztkyChristine TerrynVéronique DalsteinChun-Wen Cheng et al.

A1 Journal Article in JOURNAL OF PATHOLOGY

2014

Alpha-catenins: protein replacement as a strategy against cancer invasion and metastasis?

Koen TybergheinFrans Van RoyJolanda van Hengel

Beyond E-cadherin: roles of other cadherin superfamily members in cancer

A1 Journal Article in NATURE REVIEWS CANCER

Developing algorithms for the in silico identification of transcription factor binding sites

Stefan BroosFrans Van RoyPieter De Bleser

Intercalated discs and arrhythmogenic cardiomyopathy

Alessandra RampazzoMartina CaloreJolanda van HengelFrans Van Roy

A1 Journal Article in CIRCULATION-CARDIOVASCULAR GENETICS

Role of cell-cell adhesion complexes in embryonic stem cell biology

Tim PietersFrans Van Roy

A1 Journal Article in JOURNAL OF CELL SCIENCE

2013

Paco HulpiauFrans Van Roy

Bookchapter in Encyclopedia of metalloproteins

Cadherins and epithelial-to-mesenchymal transition

Alexander GheldofGeert Berx

A1 Journal Article in Progress in Molecular Biology and Translational Science

Delta-protocadherins in health and disease

Irene KahrKarl VandepoeleFrans Van Roy

A1 Journal Article in Progress in Molecular Biology and Translational Science

Mutations in the area composita protein T-catenin are associated with arrhythmogenic right ventricular cardiomyopathy

Jolanda van HengelMartina CaloreBarbara BauceEmanuela DazzoElisa MazzottiMarzia De BortoliAlessandra LorenzonIlena EA Li MuraGiorgia BeffagnaIlaria Rigato et al.

A1 Journal Article in EUROPEAN HEART JOURNAL

N-cadherin is required for cytodifferentiation during zebrafish odontogenesis

Barbara VerstraetenJolanda van HengelEllen SandersFrans Van RoyAnn Huysseune

A1 Journal Article in JOURNAL OF DENTAL RESEARCH

New insights into the evolution of metazoan cadherins and catenins

Paco HulpiauIsmail Sahin GülFrans Van Roy

A1 Journal Article in Progress in Molecular Biology and Translational Science

PhysBinder : improving the prediction of transcription factor binding sites by flexible inclusion of biophysical properties

Stefan BroosArne SoeteBart HoogheRaymond MoranFrans Van RoyPieter De Bleser

A1 Journal Article in NUCLEIC ACIDS RESEARCH

The molecular biology of cadherins

2012

A flexible integrative approach based on random forest improves prediction of transcription factor binding sites

Bart HoogheStefan BroosFrans Van RoyPieter De Bleser

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Bookchapter in Encyclopedia of signaling molecules

Efficient and user-friendly pluripotin-based derivation of mouse embryonic stem cells

Tim PietersLieven HaenebalckeTino HochepiedJinke D'HontJody HaighFrans Van RoyJolanda van Hengel

A1 Journal Article in STEM CELL REVIEWS AND REPORTS

Evolutionary functional analysis and molecular regulation of the ZEB transcription factors

Alexander GheldofPaco HulpiauFrans Van RoyBram De CraeneGeert Berx

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Functional analysis of the NBPF1 gene in cancer

Vanessa AndriesFrans Van RoyKarl Vandepoele

Functional analysis of the candidate tumor suppressor protein protocadherin-10

Irene KahrFrans Van Roy

Functions of p120ctn in development and disease

Tim PietersJolanda van HengelFrans Van Roy

A1 Journal Article in FRONTIERS IN BIOSCIENCE-LANDMARK

Functions of p120ctn isoforms in cell-cell adhesion and intracellular signaling

Tim PietersFrans Van RoyJolanda van Hengel

A1 Journal Article in FRONTIERS IN BIOSCIENCE-LANDMARK

Interaction of α-catulin with dystrobrevin contributes to integrity of dystrophin complex in muscle

Hyun J OhLinu S AbrahamJolanda van HengelChristophe StoveTomasz J ProszynskiKris GevaertJoseph X DiMarioJoshua R SanesFrans Van RoyHongkyun Kim

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of αT-catenin alters the hybrid adhering junctions in the heart and leads to dilated cardiomyopathy and ventricular arrhythmia following acute ischemia

Jifen LiSteven GoossensJolanda van HengelErhe GaoLan ChengKoen TybergheinXiying ShangRiet De RyckeFrans Van RoyGlenn L Radice

A1 Journal Article in JOURNAL OF CELL SCIENCE

Ocular anterior segment dysgenesis upon ablation of p120 catenin in neural crest cells

Huiyu TianEllen SandersAlbert ReynoldsFrans Van RoyJolanda van Hengel

A1 Journal Article in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

The NBPF gene family

Vanessa AndriesKarl VandepoeleFrans Van Roy

Bookchapter in Neuroblastoma : present and future

Tissue-wide overexpression of alpha-T-catenin results in aberrant trophoblast invasion but does not cause embryonic mortality in mice

Koen TybergheinSteven GoossensJody HaighFrans Van RoyJolanda van Hengel

A1 Journal Article in PLACENTA

2011

ARVCF Depletion cooperates with Tbx1 deficiency in the development of 22q11.2DS-like phenotypes in Xenopus

Hong Tran ThiMieke DelvaeyeVeerle VerschuereEmilie DescampsEllen CrabbeLuc Van HoorebekePierre McCreaDominique AdriaensFrans Van RoyKris Vleminckx

A1 Journal Article in DEVELOPMENTAL DYNAMICS

ConTra v2 : a tool to identify transcription factor binding sites across species, update 2011

Stefan BroosPaco HulpiauJeroen GalleBart HoogheFrans Van RoyPieter De Bleser

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Effects of p120ctm knockout in Wnt1 expressing cells on skull growth in mouse

Emilie DescampsEllen SandersHuiyu TianJolanda van HengelFrans Van RoyDominique Adriaens

Functional analysis of mice harboring a knockout or knockin of the alternatively spliced exon C of p120ctn

Tim PietersFrans Van RoyJolanda van Hengel

In silico approaches to studying transcriptional gene regulation: prediction of transcription factor binding sites and applications thereof

Bart HoogheFrans Van RoyPieter De Bleser

New insights into the evolution of metazoan cadherins

Paco HulpiauFrans Van Roy

A1 Journal Article in MOLECULAR BIOLOGY AND EVOLUTION

2010

Aberrant activation of fatty acid synthesis suppresses primary cilium formation and distorts tissue development

Nicolas WillemarckEvelien RysmanKoen BrusselmansGriet Van ImschootFrank VanderhoydoncKatrien MoerlooseEvelyne LerutGuido VerhoevenFrans Van RoyKris Vleminckx et al.

A1 Journal Article in CANCER RESEARCH

Analysis of N-WASP function in keratinocytes in vivo

Tine LefeverFrans Van RoyCord Brakebusch

Chibby interacts with NBPF1 and clusterin, two candidate tumor suppressors linked to neuroblastoma

Karl VandepoeleKatrien StaesVanessa AndriesFrans Van Roy

A1 Journal Article in EXPERIMENTAL CELL RESEARCH

Direct control of Hoxd1 and Irx3 expression by Wnt/β-catenin signaling during anteroposterior patterning of the neural axis in Xenopus

Sylvie JanssensTinneke DenaeyerTom DerooFrans Van RoyKris Vleminckx

A1 Journal Article in INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Perturbations in the E-cadherin/catenin junctional complex in mouse embryos resulting in exencephaly

Emilie DescampsH TianEllen SandersJolanda van HengelFrans Van RoyDominique Adriaens

Serum plakophilin-3 autoreactivity in paraneoplastic pemphigus

Jo LambertStefanie BrackeFrans Van RoyHH PasStefan BonnéSofie De Schepper

A1 Journal Article in BRITISH JOURNAL OF DERMATOLOGY

The cadherin-catenin complex and its importance in the development of brain and skull in mouse embryos

Emilie DescampsH TianE SandersJolanda van HengelFrans Van RoyDominique Adriaens

The transcriptional repressor Kaiso localizes at the mitotic spindle and is a constituent of the pericentriolar material

Adelheid SoubryKatrien StaesEef ParthoensSamuel NoppenChristophe StovePieter BogaertJolanda van HengelFrans Van Roy

A1 Journal Article in PLOS ONE

2009

Exencephalic phenotype related to defects in the E-cadherin/catening complex in mouse embryos

Emilie DescampsHuiyu TianJolanda van HengelFrans Van RoyDominique Adriaens

Involvement of members of the Cadherin superfamily in cancer

Geert BerxFrans Van Roy

A1 Journal Article in COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY

Molecular evolution of the cadherin superfamily

Paco HulpiauFrans Van Roy

A1 Journal Article in INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

TRIP6, a novel molecular partner of the MAGI-1 scaffolding molecule, promotes invasiveness

Eric ChastreMahmoud AbdessamadAlexey KruglovErik BruyneelMarc BrackeYolande Di GioiaMary C. BeckerleFrans Van RoyLarissa Kotelevets

A1 Journal Article in FASEB JOURNAL

The NBPF1 Promoter Has Been Recruited from the Unrelated EVI5 Gene Before Simian Radiation

Karl VandepoeleVanessa AndriesFrans Van Roy

A1 Journal Article in MOLECULAR BIOLOGY AND EVOLUTION

The role of the ZEB family of transcription factors in development and disease

Cindy VandewalleFrans Van RoyGeert Berx

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

2008

A constitutional translocation T(1;17)(P36.2;Q11.2) in a neuroblastoma patient disrupts NBPF1, a novel putative tumor suppressor gene

Vanessa AndriesKarl VandepoeleKatrien StaesFrans Van Roy

A constitutional translocation t(1;17)(p36.2;q11.2) in a neuroblastoma patient disrupts the human NBPF1 and ACCN1 genes

Karl VandepoeleVanessa AndriesNadine Van RoyKatrien StaesJo VandesompeleGenevieve LaureysEls De SmetGeert BerxFranki SpelemanFrans Van Roy

A1 Journal Article in PLOS ONE

A constitutional translocation t(1;17)(p36.2;q11.2) in a neuroblastoma patient disrupts the the human NBPF1 and ACCN1 genes

Frans Van RoyKlaas VandepoeleNadine Van RoyVanessa AndriesKatrien StaesJo VandesompeleGenevieve LaureysEls De SmetGeert BerxFranki Speleman

Canonical Wnt signaling controls proliferation of retinal stem/progenitor cells in postembryonic Xenopus eyes

Tinneke DenayerM LOCKERC BORDAYTom DerooSylvie JanssensA HECHTFrans Van RoyM PERRONKris Vleminckx

A1 Journal Article in STEM CELLS

Chicken beta-globin insulator overcomes variegation of transgenes in Xenopus embryos

Belaïd SekkaliHong Tran ThiEllen CrabbeChristophe De BeuleFrans Van RoyKris Vleminckx

A1 Journal Article in FASEB JOURNAL

ConTra: a promoter alignment analysis tool for identification of transcription factor binding sites across species

Bart HooghePaco HulpiauFrans Van RoyPieter De Bleser

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Continuous cell injury promotes hepatic tumorigenesis in Cdc42-deficient mouse liver

Jolanda van HengelPetra D'HoogeBart HoogheXunwei WuLouis LibbrechtRita De VosFabio QuondamatteoMartina KlemptCord BrakebuschFrans Van Roy

A1 Journal Article in GASTROENTEROLOGY

Endoplasmic reticulum quality control: a new mechanism of E-cadherin regulation and its implication in cancer

Joana Simoes-CorreiaJ FIGUEIREDOC OLIVEIRAJ VAN HENGELR SERUCAFrans Van RoyG SURIANO

A1 Journal Article in HUMAN MOLECULAR GENETICS

Expression of protocadherin-1 (Pcdh1) during mouse development

C REDIESJ HEYDERT KOHOUTEKKatrien StaesFrans Van Roy

A1 Journal Article in DEVELOPMENTAL DYNAMICS

Insulin-like growth factor-I receptor, E-cadherin and alpha v integrin form a dynamic complex under the control of alpha-catenin

A CANONICIW STEELANTV RIGOTA KHOMITCH-BAUDH BOUTAGHOU-CHERIDErik BruyneelFrans Van RoyF GARROUSTEG POMMIERF ANDRÉ

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

Low nucleosome occupancy is encoded around functional human transcription factor binding sites

Floris DaenenFrans Van RoyPieter De Bleser

A1 Journal Article in BMC GENOMICS

Plakophilin-3-deficient mice develop hair coat abnormalities and are prone to cutaneous inflammation

Tatyana SklyarovaStefan BonnéPetra D'HoogeGeertrui DeneckerSteven GoossensRiet De RyckeGaetan BorgonieMichael BöslFrans Van RoyJolanda van Hengel

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

The E-cadherin-repressed hNanos1 gene induces tumor cell invasion by upregulating MT1-MMP expression

A BONNOMETM POLETTEKristin StrumaneC GILLESV DALSTEINC KILEZTKYGeert BerxFrans Van RoyP BIREMBAUTB NAWROCKI-RABY

A1 Journal Article in ONCOGENE

The cell-cell adhesion molecule E-cadherin

Frans Van RoyGeert Berx

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Variant HNF1 Modulates Epithelial Plasticity of Normal and Transformed Ovary Cells

A TOMASSETTIG DE SANTISG CASTELLANOS MIOTTIM MAZZID TOMASONIFrans Van RoyML CARCANGIUS CANEVARI

A1 Journal Article in NEOPLASIA

alpha-Catulin, a Rho signalling component, can regulate NF-kappa B through binding to IKK-beta, and confers resistance to apoptosis

C WIESNERG WINSAUERU RESCHM HOETHJA SCHMIDJolanda van HengelFrans Van RoyBR BINDERR DE MARTIN

A1 Journal Article in ONCOGENE

2007

A distance difference matrix approach to identifying transcription factors that regulate differential gene expression

Pieter De BleserBart HoogheDominique VliegheFrans Van Roy

A1 Journal Article in GENOME BIOLOGY

A unique and specific interaction between alpha T-catenin and plakophilin-2 in the area composita, the mixed-type junctional structure of cardiac intercalated discs

Steven GoossensBarbara JanssensStefan BonnéRiet De RyckeFilip BraetJolanda van HengelFrans Van Roy

A1 Journal Article in JOURNAL OF CELL SCIENCE

Activation of NF-kappa B by Akt upregulates Snail expression and induces epithelium mesenchyme transition

S JULIENI PUIGE CARETTIJ BONAVENTUREL NELLESFrans Van RoyC DARGEMONTA GARCIA DE HERREROSA BELLACOSAL LARUE

A1 Journal Article in ONCOGENE

Description and mapping of the resistance of DBA/2 mice to TNF-induced lethal shock

Ben WielockxJan StaelensLeen PuimègeIneke VanlaereMaarten Van RoyPhilippe Van LintFrans Van RoyClaude Libert

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Diverse functions of p 20ctn in tumors

Jolanda van HengelFrans Van Roy

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Insertion of an HERV(K) LTR in the intron of NBPF3 is not required for its transcriptional activity

Karl VandepoeleFrans Van Roy

A1 Journal Article in VIROLOGY

The transcription factor ZEB1 (delta EF1) represses Plakophilin 3 during human cancer progression

K AIGNERL DESCOVICHM MIKULAA SULTANB DAMPIERStefan BonnéFrans Van RoyW MIKULITSM SCHREIBERT BRABLETZ et al.

A1 Journal Article in FEBS LETTERS

Truncated isoform of mouse alpha T-catenin is testis-restricted in expression and function

Steven GoossensBarbara JanssensGriet VanpouckeRiet De RyckeJ VAN HENGELFrans Van Roy

A1 Journal Article in FASEB JOURNAL

2006

A new generation of JASPAR, the open-access repository for transcription factor binding site profiles

Dominique VliegheA SANDELINPieter De BleserKris VleminckxWW WASSERMANFrans Van RoyB LENHARD

A1 Journal Article in NUCLEIC ACIDS RESEARCH

E-cadherin regulates human Nanos1, which interacts with p120ctn and induces tumor cell migration and invasion

Kristin StrumaneArnaud BonnometChristophe StoveRoosmarijn VandenbrouckeBeatrice Nawrocki-RabyErik BruyneelMarcus MareelPhilippe BirembautGeert BerxFrans Van Roy

A1 Journal Article in CANCER RESEARCH

In vivo tracing of canonical Wnt signaling in Xenopus tadpoles by means of an inducible transgenic reporter tool

Tinneke DenayerFrans Van RoyKris Vleminckx

A1 Journal Article in FEBS LETTERS

Regulation of vimentin by SIP1 in human epithelial breast tumor cells

S BINDELSM MESTDAGTCindy VandewalleN JACOBSL VOLDERSA NOELFrans Van RoyGeert BerxJM FOIDARTC GILLES

A1 Journal Article in ONCOGENE

The wild-derived inbred mouse strain SPRET/Ei is resistant to LPS and defective in IFN-beta production

Tina MahieuJM PARKH REVETSB PASCHEA LENGELINGJan StaelensAndy WullaertIneke VanlaereTino HochepiedFrans Van Roy et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Writing readable prose - When planning a scientific manuscript, following a few simple rules has a large impact

Amin BredanFrans Van Roy

Editorial material

2005

A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution

Karl VandepoeleNadine Van RoyKatrien StaesFranki SpelemanFrans Van Roy

A1 Journal Article in MOLECULAR BIOLOGY AND EVOLUTION

A role for Kaiso-p120ctn complexes in cancer?

Frans Van RoyPD MCCREA

A1 Journal Article in NATURE REVIEWS CANCER

Cadherin-mediated cell-cell adhesion in the testis

Steven GoossensFrans Van Roy

A1 Journal Article in FRONTIERS IN BIOSCIENCE

Expression and nuclear location of the transcriptional repressor kaiso is regulated by the tumor microenvironment

Adelheid SoubryJolanda van HengelEef ParthoensC COLPAERTE VAN MARCKD WALTREGNYAB REYNOLDSFrans Van Roy

A1 Journal Article in CANCER RESEARCH

Nuclear translocation of alpha N-catenin by the novel zinc finger transcriptional repressor ZASC1

Sven BogaertsAnn VanlandschootJolanda van HengelFrans Van Roy

A1 Journal Article in EXPERIMENTAL CELL RESEARCH

SIP1/ZEB2 induces EMT by repressing genes of different epithelial cell-cell junctions

Cindy VandewalleJoke ComijnBram De CraenePetra VermassenErik BruyneelH AndersenE TulchinskyFrans Van RoyGeert Berx

A1 Journal Article in NUCLEIC ACIDS RESEARCH

The transcription factor snail induces tumor cell invasion through modulation of the epithelial cell differentiation program

Bram De CraeneBarbara GilbertChristophe StoveErik BruyneelFrans Van RoyGeert Berx

A1 Journal Article in CANCER RESEARCH

Unraveling signalling cascades for the Snail family of transcription factors

Bram De CraeneFrans Van RoyGeert Berx

A1 Journal Article in CELLULAR SIGNALLING

δ-Protocadherins: a gene family expressed differentially in the mouse brain

Koen VanhalstPatrick KoolsKatrien StaesFrans Van RoyC Redies

A1 Journal Article in CMLS-CELLULAR AND MOLECULAR LIFE SCIENCES

2004

Alpha-catenin is required for IGF-I-induced cellular migration but not invasion in human colonic cancer cells

F ANDRÉBarbara JanssensErik BruyneelFrans Van RoyC GESPACHMarcus MareelMarc Bracke

A1 Journal Article in ONCOGENE

Breaking the species barrier: derivation of germline-competent embryonic stem cells from Mus spretus x C57BL/6 hybrids

Tino HochepiedLuc SchoonjansJan StaelensVeerle KreemersSophie DanloyLeen PuimègeDésiré CollenFrans Van RoyClaude Libert

A1 Journal Article in STEM CELLS

Cadherins in cancer

Kristin StrumaneGeert BerxFrans Van Roy

Bookchapter in Handbook of Experimental Pharmacology

Characterization of a novel zinc finger protein ANC_2H01 (ZASC1)

Sven BogaertsFrans Van Roy

Combined subtractive cDNA cloning and array CGH: an efficient approach for identification of overexpressed genes in DNA amplicons

Katleen De PreterFilip PattynGeert BerxKristin StrumaneBjörn MentenFrans Van RoyAnne De PaepeFranki SpelemanJo Vandesompele

A1 Journal Article in BMC GENOMICS

Differential downregulation of alpha T-catenin expression in placenta: trophoblast cell type-dependent imprinting of the CTNNA3 gene

M VAN DIJKJ MULDERSA KONSTBarbara JanssensFrans Van RoyM BLANKENSTEINC OUDEJANS

A1 Journal Article in GENE EXPRESSION PATTERNS

Epithelial cell plasticity by dynamic transcriptional regulation of E-cadherin

Geert BerxFrans Van Roy

Bookchapter in Rise and fall of epithelial phenotype

GATA-4 and MEF2C transcription factors control the tissue-specific expression of the αT-catenin gene CTNNA3

Griet VanpouckeSteven GoossensBram De CraeneBarbara GilbertFrans Van RoyGeert Berx

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Global inhibition of Lef1/Tcf-dependent Wnt signaling at its nuclear end point abrogates development in transgenic Xenopus embryos

Tom DerooTinneke DenayerFrans Van RoyKris Vleminckx

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Implication of the MAGI-1b/PTEN signalosome in stabilization of adherens junctions and suppression of invasiveness

Larissa KotelevetsJolanda van HengelErik BruyneelMarcus MareelFrans Van RoyE CHASTRE

A1 Journal Article in FASEB JOURNAL

P120 catenin is required for morphogenetic movements involved in the formation of the eyes and the cranlofacial skeleton in Xenopus

Malgorzata CiesiolkaMieke DelvaeyeGriet Van ImschootVeerle VerschuereP MCCREAFrans Van RoyKris Vleminckx

A1 Journal Article in JOURNAL OF CELL SCIENCE

Response of TNF-hyporesponsive SPRET/Ei mice in models of inflammatory disorders

Jan StaelensLeen PuimègeTina MahieuGwenda PynaertTino HochepiedAnnelies VandenabeeleJohan GrootenDimitris KontoyiannisFrans Van RoyGeorge Kollias et al.

A1 Journal Article in MAMMALIAN GENOME

Stability of dendritic spines and synaptic contacts is controlled by alpha N-catenin

K ABEO CHISAKAFrans Van RoyM TAKEICHI

A1 Journal Article in NATURE NEUROSCIENCE

alpha-T-catenin is expressed in human brain and interacts with the Wnt signaling pathway but is not responsible for linkage to chromosome 10 in Alzheimer's disease

V BUSBYSteven GoossensP NOWOTNYG HAMILTONS SMEMOD HAROLDD TURICL JEHUA MYERSM WOMICK et al.

A1 Journal Article in NEUROMOLECULAR MEDICINE

2003

Assessment of the CTNNA3 gene encoding human alpha T-catenin regarding its involvement in dilated cardiomyopathy

Barbara JanssensB MOHAPATRAM VATTASteven GoossensGriet VanpouckePatrick KoolsTony MontoyeJolanda van HengelNE BOWLESFrans Van Roy et al.

A1 Journal Article in HUMAN GENETICS

Defining desmosomal plakophilin-3 interactions

Stefan BonnéBarbara GilbertM HATZFELDX CHENKJ GREENFrans Van Roy

A1 Journal Article in JOURNAL OF CELL BIOLOGY

E-cadherin mediates MMP down-regulation in highly invasive bronchial tumor cells

B NAWROCKI-RABYC GILLESM POLETTEC MARTINELLA-CATUSSEN BONNETE PUCHELLEJM FOIDARTFrans Van RoyP BIREMBAUT

A1 Journal Article in AMERICAN JOURNAL OF PATHOLOGY

Functional and molecular characterization of the epithelioid to round transition in human colorectal cancer LoVo cells

PHILIP DEBRUYNEStefan VermeulenGeert BerxM POCARDASC DA ROCHAXD LIL CIRNESMF POUPONFrans Van RoyMarcus Mareel

A1 Journal Article in ONCOGENE

Inflammatory breast cancer shows angiogenesis with high endothelial proliferation rate and strong E-cadherin expression

CG COLPAERTPB VERMEULENI BENOYAdelheid SoubryFrans Van RoyP VAN BEESTG GOOVAERTSLY DIRIXP VAN DAMSB FOX et al.

A1 Journal Article in BRITISH JOURNAL OF CANCER

Molecular and functional characterisation of the tumor necrosis factor associated proteins TRAF1 and TRAF2

Isabelle CarpentierRudi BeyaertFrans Van Roy

Regulation of interleukin-1 and endotoxin induced responses by alternative splicing of MyD88

Sophie JanssensRudi BeyaertFrans Van Roy

The p120 catenin regulates morphogenetic movements in early xenopus embryos by modifying the activity of the rho-family small Gtpases.

M CIESIOLKAM DELVAEYEGriet Van ImschootFrans Van RoyKris Vleminckx

The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines

SJ GRILLEA BELLACOSAJ UPSONAJ KLEIN-SZANTOFrans Van RoyW LEE-KWONM DONOWITZPN TSICHLISL LARUE

A1 Journal Article in CANCER RESEARCH

The role of E-cadherin in epithelial differentiation and cancer progression

Kristin StrumaneFrans Van RoyGeert Berx

Bookchapter in Recent Research Development in Cellular Biochemistry

2002

A clinio-pathological and biological approach to the function of the c-erbB-2 protein in breast cancer

CR DE POTTERV DE CORTER BEYAERTJ QUATACKERNicolas Van LarebekeFrans Van RoyJ VANDEKERCKHOVEMarcus MareelH ROELS

A novel role for p120 catenin in E-cadherin function.

RC IRETONMA DAVISJolanda van HengelDJ MARINERK BARNESMA THORESONPZ ANASTASIADISL MATRISIANLM BUNDYL SEALY et al.

A1 Journal Article in JOURNAL OF CELL BIOLOGY

Downregulation in vivo of the invasion-suppressor molecule E-cadherin in experimental and clinical cancer

Marcus MareelK VLEMINCKXS VERMEULENG YANMarc BrackeFrans Van Roy

Hyporesponsiveness of SPRET/Ei mice to lethal shock induced by tumor necrosis factor and implications for a TNF-based antitumor therapy

Jan StaelensBen WielockxLeen PuimègeFrans Van RoyJean-Louis GuénetClaude Libert

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In search of sticky protocols.

A2 Journal Article in NATURE CELL BIOLOGY

Investigation of tumour-invasion mechanisms.

Marcus MareelFrans Van RoyL MESSIAENMarc BrackeE BOGHAERTP COOPMAN

Isolation and characterization of XKaiso, a transcriptional repressor that associates with the catenin Xp120(ctn) in Xenopus laevis.

SW KIMX FANGH JIAF PAULSONJM DANIELMalgorzata CiesiolkaFrans Van RoyPD MCCREA

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Localization of the 17q breakpoint of a constitutional 1;17 translocation in a patient with neuroblastoma within a 25-kb segment located between the ACCN1 and TLK2 genes and near the distal breakpoints of two microdeletions in neurofibromatosis type I patients.

Nadine Van RoyJo VandesompeleGeert BerxK STAESMireille Van GeleEls De SmetAnne De PaepeGenevieve LaureysP VAN DER DRIFTR VERSTEEG et al.

A1 Journal Article in GENES CHROMOSOMES & CANCER

Modulation of invasion in vitro and in vivo

Marcus MareelK VLEMINCKXY GAONicolas Van LarebekeMarc BrackeFrans Van Roy

Molecular mechanisms of cancer invasion

Marcus MareelME BRACKEFrans Van RoyP DE BAETSELIER

Protein binding and functional characterization of plakophilin 2 - Evidence for its diverse roles in desmosomes and beta-catenin signaling.

XY CHENStefan BonnéM HATZFELDFrans Van RoyKJ GREEN

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Smad4 induces the tumor suppressor E-cadherin and P-cadherin in colon carcinoma cells.

N MULLERA REINACHER-SCHICKS BALDUSJolanda van HengelGeert BerxA BAARFrans Van RoyW SCHMIEGELI SCHWARTE-WALDHOFF

A1 Journal Article in ONCOGENE

Spontaneous and oncogene-mediated acquisition of the invasive phenotype by cells in culture.

Marcus MareelP COOPMANC DRAGONETTIWalther FiersJ GAOL MESSIAENFrans Van Roy

The human alpha E-catenin gene CTNNA1: mutational analysis and rare occurrence of a truncated splice variant.

Griet VanpouckeFriedel NolletS TEJPARJJ CASSIMANFrans Van Roy

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION

2001

Expression of the E-cadherin-catenin complex in lung neuroendocrine tumours.

CE CLAVELFriedel NolletGeert BerxS TEJPARB NAWORCKI-RABYHH KAPLANFrans Van RoyPL BIREMBAUT

A1 Journal Article in JOURNAL OF PATHOLOGY

Identificatie en functionele karakterisering van eiwitten die binden met het zinkvingereiwit A20

Sofie Van HuffelFrans Van RoyRudi Beyaert

Quantitative cell dispersion analysis: New test to measure tumor cell aggressiveness.

BN RABYM POLETTEC GILLESC CLAVELKristin StrumaneM MATOSJM ZAHMFrans Van RoyN BONNETP BIREMBAUT

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

The E-cadherin/catenin complex: an important gatekeeper in breast cancer tumorigenesis and malignant progression

Geert BerxFrans Van Roy

A1 Journal Article in BREAST CANCER RESEARCH

The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number.

Koen VanhalstPatrick KoolsE VANDEN EYNDEFrans Van Roy

A1 Journal Article in FEBS LETTERS

The lipid phosphatase activity of PTEN is critical for stabilizing intercellular junctions and reverting invasiveness.

Larissa KotelevetsJolanda van HengelErik BruyneelMarcus MareelFrans Van RoyE CHASTRE

A1 Journal Article in JOURNAL OF CELL BIOLOGY

The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion.

Joke ComijnGeert BerxP VERMASSENK VERSCHUERENL VAN GRUNSVENErik BruyneelMarcus MareelD HUYLEBROECKFrans Van Roy

A1 Journal Article in MOLECULAR CELL

alpha T-Catenin: a novel tissue-specific beta-catenin-binding protein mediating strong cell-cell adhesion.

Barbara JanssensSteven GoossensK STAESB GILBERTJolanda van HengelC COLPAERTErik BruyneelMarcus MareelFrans Van Roy

A1 Journal Article in JOURNAL OF CELL SCIENCE

2000

Assignment of the plakophilin-9 gene (PKP2) and a plakophilin-2 pseudogene (PKP2P1) to human chromosome bands 12p11 and 12p13, respectively, by in situ hybridization.

Stefan BonnéJolanda van HengelFrans Van Roy

A1 Journal Article in CYTOGENETICS AND CELL GENETICS

Characterization of three novel human cadherin genes (CDH7, CDH19, and CDH20) clustered on chromosome 18q22-q23 and with high homology to chicken cadherin-7.

Patrick KoolsC VAN IMSCHOOTFrans Van Roy

A1 Journal Article in GENOMICS

Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.

Friedel NolletPatrick KoolsFrans Van Roy

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

Studie van caspasen en hun activeringsmechanismen

Peter SchotteRudi BeyaertFrans Van Roy

The p300/CBP acetyltransferases function as transcriptional coactivators of beta-catenin in vertebrates.

Andreas HechtKris VleminckxMarc P. StemmlerFrans Van RoyRolf Kemler

A1 Journal Article in EMBO JOURNAL

The protein-tyrosine phosphatase SHP-1 binds to and dephosphorylates p120 catenin.

H KEILHACKU HELLMANJolanda van HengelFrans Van RoyJ GODOVAC-ZIMMERMANNFD BOHMER

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

1999

Assignment of cadherin-4 (R-cadherin, CDH4) to human chromosome band 20q13.3.

Patrick KoolsKoen VanhalstFrans Van Roy

A1 Journal Article in CYTOGENETICS AND CELL GENETICS

Distinct deleted regions on chromosome segment 16q23-24 associated with metastases in prostate cancer.

CD LIGeert BerxC LARSSONG AUERU ASPENBLADY PANB SUNDELINP EKMANM NORDENSKJOLDFrans Van Roy et al.

A1 Journal Article in GENES CHROMOSOMES & CANCER

Human a-catulin, a novel a-catenin-like molecule with conserved genomic structure, but deviating alternative splicing.

Barbara JanssensK STAESFrans Van Roy

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION

Identification of eleven novel tumor-associated E-cadherin mutations

Karl-Friedrich BeckerUlrike ReichChristina SchottIngrid BeckerGeert BerxFrans Van RoyHeinz Höfler

A2 Journal Article in HUMAN MUTATION

Inhibition of adhesion and induction of epithelial cell invasion by HAV-containing E-cadherin-specific peptides.

V NOEJ WILLEMSJoël VandekerckhoveFrans Van RoyErik BruyneelMarcus Mareel

A1 Journal Article in JOURNAL OF CELL SCIENCE

Neuroblastoma: from molecular cytogenetics to gene expression profiling

Jo VandesompeleNadine Van RoyGeert BerxD PLANTAZAnne De PaepeGenevieve LaureysFrans Van RoyFranki Speleman

Nuclear localization of the p120ctn Armadillo-like catenin is counteracted by a nuclear export signal and by E-cadherin expression

Jolanda van HengelPeter VanhoenackerKatrien StaesFrans Van Roy

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plakophilin-3, a novel Armadillo-like protein present in nuclei and desmosomes of epithelial cells.

Stefan BonnéJolanda van HengelFriedel NolletPatrick KoolsFrans Van Roy

A1 Journal Article in JOURNAL OF CELL SCIENCE

Predominance of beta-catenin mutations and beta-catenin dysregulation in sporadic aggressive fibromatosis (desmoid tumor).

S TEJPARFriedel NolletC LIJS WUNDERG MICHILSP DAL CINE VAN CUTSEMB BAPATFrans Van RoyJJ CASSIMAN et al.

A1 Journal Article in ONCOGENE

The human cadherin-10 gene: complete coding sequence, predominant expression in the brain, and mapping on chromosome 5p13-14.

Patrick KoolsKoen VanhalstE VAN DEN EYNDEFrans Van Roy

A1 Journal Article in FEBS LETTERS

The role of the E-cadherin/catenin adhesion complex in the development and progression of cancer.

Friedel NolletGeert BerxFrans Van Roy

A2 Journal Article in Molecular Cell Biol. Res. Commun.

The αE-catenin gene (CTNNA1) acts as an invasion-suppressor gene in human colon cancer cells

Stefan VermeulenFriedel NolletE TEUGELSKM VENNEKENSFransiska MalfaitJan PhilippéFranki SpelemanMarc BrackeFrans Van RoyMarcus Mareel

A1 Journal Article in ONCOGENE

hMSH6 deficiency and inactivation of the alpha E-catenin invasion-suppressor gene in HCT-8 colon cancer cells.

SJ VERMEULENPhilip DebruyneG MARRAFranki SpelemanP BOUKAMPJ JIRICNYAP CUTHBERTRF NEWBOLDFriedel NolletFrans Van Roy et al.

A1 Journal Article in CLINICAL & EXPERIMENTAL METASTASIS

ß-Catenin mutations are more frequent in small colorectal adenomas than in larger adenomas and invasive carcinomas.

WS SAMOWITZMD POWERSLN SPIRIOF NOLLETFrans Van RoyML SLATTERY

A1 Journal Article in CANCER RESEARCH

1998

Chromosomal mapping of human armadillo genes belonging to the p120(ctn)/plakophilin subfamily.

Stefan BonnéJolanda van HengelFrans Van Roy

A1 Journal Article in GENOMICS

Cytoplasmic redistribution of E-cadherin-catenin adhesion complex is associated with down-regulated tyrosine phosphorylation of E-cadherin in human bronchopulmonary carcinomas.

B NAWROCKIM POLETTEJolanda van HengelJM TOURNIERFrans Van RoyP BIREMBAUT

A1 Journal Article in AMERICAN JOURNAL OF PATHOLOGY

Did the four human cancer cell lines DLD-1, HCT-15, HCT-8, and HRT-18 originate from one and the same patient?

Stefan J VermeulenTR ChenFranki SpelemanFriedel NolletFrans Van RoyMarcus Mareel

A1 Journal Article in CANCER GENETICS AND CYTOGENETICS

Dysregulation of the E-cadherin/catenin complex by irreversible mutations in human carcinomas.

Geert BerxFriedel NolletFrans Van Roy

A1 Journal Article in CELL ADHESION AND COMMUNICATION

E-cadherin and metastasin (mts-1/S100A4) expression levels are inversely regulated in two tumor cell families

Annick KeirsebilckStefan BonnéErik BruyneelPetra VermassenEugene LukanidinMarcus MareelFrans Van Roy

A1 Journal Article in CANCER RESEARCH

Het menselijk E-cadherine/catenine complex: een potente invasie- en tumorsuppressor

Marcus MareelFrans Van Roy

A4 Journal Article in VERHANDELINGEN VAN DE KONINKLIJKE ACADEMIE VOOR GENEESKUNDE VAN BELGIË

Mechanisms of downregulation of transfected E-cadherin cDNA during formation of invasive tumors in syngeneic mice

Annick KeirsebilckLeen Van HoordeY GAOGeorges De BruyneErik BruyneelPetra VermassenMarcus MareelFrans Van Roy

A1 Journal Article in INVASION & METASTASIS

Molecular cloning of the human p120(ctn) catenin gene (CTNND1): Expression of multiple alternatively spliced isoforms.

Annick KeirsebilckStefan BonnéK STAESJolanda van HengelFriedel NolletA REYNOLDSFrans Van Roy

A1 Journal Article in GENOMICS

Mutations of the human E-cadherin (CDH1) gene.

Geert BerxKF BECKERH HOFLERFrans Van Roy

A1 Journal Article in HUMAN MUTATION

α-Catenin-vinculin interaction functions to organize the apical junctional complex in epithelial cells

Mitsuko Watabe-UchidaNaoshige UchidaYuzo ImamuraAkira NagafuchiKazushi FujimotoTadashi UemuraStefan VermeulenFrans Van RoyEileen D AdamsonMasatoshi Takeichi

A1 Journal Article in JOURNAL OF CELL BIOLOGY

1997

Activation and inactivation of invasion-suppressor molecules : in vitro analysis

Marcus MareelStefan VermeulenV. NoëLeen Van HoordeErik BruyneelFrans Van RoyMarc Bracke

Bookchapter in Forschung ohne Tierversuche 1996

Allelic imbalance at the beta-catenin gene (CTNNB1 at 3p22-21.3) in various human tumor types.

Friedel NolletA VANDENBERGAM KERSEMAEKERSAM CLETONJANSENGeert BerxAY VANDERVEENC EICHPERGERI WIELANDJ DEGREVEGJ LIEFERS et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF ONCOLOGY

An efficient and reliable multiplex PCR-SSCP mutation analysis test applied to the human E-cadherin gene.

Geert BerxFriedel NolletKristin StrumaneFrans Van Roy

A1 Journal Article in HUMAN MUTATION

E-cadherin gene alterations are rare events in thyroid tumors.

P SOARESGeert BerxFrans Van RoyM SOBRINHO-SIMOES

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

E-cadherin inactivation in lobular carcinoma in situ of the breast: an early event in tumorigenesis.

CBJ VOSAM CLETONJANSENGeert BerxWJF DELEEUWNT TERHAARFrans Van RoyCJ CORNELISSEJL PETERSEMJ VANDEVIJVER

A1 Journal Article in BRITISH JOURNAL OF CANCER

Molecular cloning of an alternative human alpha E-catenin cDNA.

M LINKELSMJG BUSSEMAKERSFriedel NolletCM EWINGFrans Van RoyJA SCHALKEN

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Molecular mechanisms of cancer invasion

M MAREELME BRACKEFrans Van RoyP DE BAETSELIER

Mutation of alpha-catenin results in invasiveness of human HCT-8 colon cancer cells.

SJ VERMEULENF NOLLETE TEUGELSJan PhilippéFranki SpelemanFrans Van RoyMarc BrackeMarcus Mareel

A1 Journal Article in ANNALS OF THE NEW YORK ACADEMY OF SCIENCES

Progression of familial adenomatous polyposis (FAP) colonic cells after transfer of the src or polyoma middle T oncogenes: Cooperation between src and HGF/Met in invasion.

S EMPEREURS DJELLOULY DIGIOIAErik BruyneelMarcus MareelJ VANHENGELFrans Van RoyP COMOGLIOS COURTNEIDGEC PARASKEVA et al.

A1 Journal Article in BRITISH JOURNAL OF CANCER

Protein kinase C activation upregulates intercellular adhesion of a-catenin-negative human colon cancer cell variants via induction of desmosomes

J VAN HENGELL GOHONErik BruyneelStefan VermeulenM CORNELISSENMarcus MareelFrans Van Roy

A2 Journal Article in Journal Cell Biol., 137, pp. 1103-1116

Protein kinase C activation upregulates intercellular adhesion of alpha-catenin-negative human colon cancer cell variants via induction of desmosomes.

J VANHENGELL GOHONErik BruyneelS VERMEULENM CORNELISSENMarcus MareelFrans Van Roy

A1 Journal Article in JOURNAL OF CELL BIOLOGY

Simultaneous loss of E-cadherin and catenins in invasive lobular breast cancer and lobular carcinoma in situ.

WJF DELEEUWGeert BerxCBJ VOSJL PETERSEMJ VANDEVIJVERS LITVINOVFrans Van RoyCJ CORNELISSEAM CLETONJANSEN

A1 Journal Article in JOURNAL OF PATHOLOGY

1996

Cadherin/catenin complex: A target for antiinvasive therapy?

Marcus MareelGeert BerxFrans Van RoyMarc Bracke

A1 Journal Article in JOURNAL OF CELLULAR BIOCHEMISTRY

E-cadherin is inactivated in a majority of invasive human lobular breast cancers by truncation mutations throughout its extracellular domain.

Geert BerxAM CLETONJANSENKristin StrumaneWJF DELEEUWFriedel NolletFrans Van RoyC CORNELISSE

A1 Journal Article in ONCOGENE

Genomic organization of the human beta-catenin gene (CTNNB1).

Friedel NolletGeert BerxF MOLEMANSFrans Van Roy

A1 Journal Article in GENOMICS

Growth inhibition in clonal subpopulations of a human epithelioid sarcoma cell line by retinoic acid and tumour necrosis factor alpha.

R ENGERSFrans Van RoyT HEYMERU RAMPR MOLLM DIENSTU FRIEBEA POHLHE GABBERTCD GERHARZ

A1 Journal Article in BRITISH JOURNAL OF CANCER

Morphotypic plasticity in vitro and in nude mice of epithelial mouse mammary cells (NMuMG) displaying an epithelioid (e) or a fibroblastic (f) morphotype in culture.

C VANDENBROECKEKris VleminckxG DEBRUYNEL VANHOORDELuc VakaetFrans Van RoyMarcus Mareel

A1 Journal Article in CLINICAL & EXPERIMENTAL METASTASIS

Regulation of the invasion suppressor function of the cadherin/catenin complex

Stefan VermeulenVeerle Van MarckLeen Van HoordeFrans Van RoyMarc BrackeMarcus Mareel

A2 Journal Article in Path. Res. Pract., 192

Regulation of the invasion suppressor function of the cadherin/catenin complex

S VERMEULENV VAN MARCKL VAN HOORDEFrans Van RoyM BRACKEM MAREEL

A2 Journal Article in Pathol. Res. Pract. 192, 694-707, 1996

Regulation of the invasion suppressor function of the cadherin/catenin complex.

S VERMEULENV VANMARCKL VANHOORDEFrans Van RoyMarc BrackeMarcus Mareel

A1 Journal Article in PATHOLOGY RESEARCH AND PRACTICE

Syndecan-1 expression in mammary epithelial tumor cells is E-cadherin-dependent.

S LEPPAKris VleminckxFrans Van RoyM JALKANEN

A1 Journal Article in JOURNAL OF CELL SCIENCE

Tamoxifen and the E-cadherin/catenin complex.

Marc BrackeFrans Van RoyV CASTRONOVOMarcus Mareel

Bookchapter in Tamoxifen : Beyond the Antiestrogen

The E-cadherin/catenin complex in invasion and metastasis

Marc BrackeFrans Van RoyMarcus Mareel

Bookchapter in Attempts to understand metastasis formation I : metastasis-related molecules

The E-cadherin/catenin complex in invasion and metastasis.

Marc BrackeFrans Van RoyMarcus Mareel

A1 Journal Article in CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY

The cadherin/catenin complex: a target for antiinvasive therapy ?

Marcus MareelGeert BerxFrans Van RoyMarc Bracke

A2 Journal Article in Journal Cellular Biochem., 61

1995

ACTIVATION OF THE E-CADHERIN/CATENIN COMPLEX IN HUMAN MCF-7 BREAST-CANCER CELLS BY ALL-TRANS-RETINOIC ACID

Stefan VermeulenErik BruyneelFrans Van RoyMarcus MareelMarc Bracke

A1 Journal Article in BRITISH JOURNAL OF CANCER

Assignment of the human beta-catenin gene (CTNNB1) to 3p22->p21.3 by fluorescence in situ hybridization.

J VANHENGELF NOLLETGeert BerxNadine Van RoyFranki SpelemanFrans Van Roy

A1 Journal Article in CYTOGENETICS AND CELL GENETICS

CANCER METASTASIS - NEGATIVE REGULATION BY AN INVASION-SUPPRESSOR COMPLEX

Marcus MareelMarc BrackeFrans Van Roy

A1 Journal Article in CANCER DETECTION AND PREVENTION

CLONING AND CHARACTERIZATION OF THE HUMAN INVASION SUPPRESSOR GENE E-CADHERIN (CDH1).

Geert BerxK STAESJ VANHENGELF MOLEMANSMJG BUSSEMAKERSA VANBOKHOVENFrans Van Roy

A1 Journal Article in GENOMICS

E-cadherin is a tumour invasion suppressor gene mutated in human lobular breast cancers.

Geert BerxAM CLETONJANSENF NOLLETWJF DELEEUWMJ VANDEVIJVERC CORNELISSEFrans Van Roy

A1 Journal Article in EMBO JOURNAL

ISOLATION AND CHARACTERIZATION OF A HUMAN PSEUDOGENE (CTNNAP1) FOR ALPHA-E-CATENIN (CTNNA1) - ASSIGNMENT OF THE PSEUDOGENE TO 5Q22 AND THE ALPHA-E-CATENIN GENE TO 5Q31.

F NOLLETJ VANHENGELGeert BerxF MOLEMANSFrans Van Roy

A1 Journal Article in GENOMICS

Novel function for all-trans-retinoic acid: induction of adhesive function of E-cadherin in human cancer cells

Stefan VermeulenErik BruyneelFrans Van RoyMarc BrackeMarcus Mareel

A1 Journal Article in CELL BIOLOGY INTERNATIONAL

Transition from the noninvasive to the invasive phenotype and loss of α-catenin in human colon cancer cells

Stefan VermeulenErik BruyneelMarc BrackeGeorges De BruyneKrist'l M VennekensKris VleminckxGeert BerxFrans Van RoyMarcus Mareel

A1 Journal Article in CANCER RESEARCH

1994

Downregulation in vivo of the invasion-suppressor molecule E-cadherin in experimental and clinical cancer

Marcus MareelKris VleminckxStefan VermeulenY GAOMarc BrackeFrans Van Roy

Bookchapter in Proceedings of the 24th International Symposium of the Princess Takamatsu Cancer Research Fund

Downregulation in vivo of the invasion-suppressor molecule E-cadherin in experimental and clinical cancer

Marcus MareelK VLEMINCKXStefan VermeulenGY ANMarc BrackeFrans Van Roy

Enlarged cell-associated proteoglycans abolish E-cadherin functionality in invasive tumor cells

Kris VleminckxJoris DemanErik BruyneelGeert VandenbosscheAnnick KeirsebilckMarcus MareelFrans Van Roy

A1 Journal Article in CANCER RESEARCH

IN-VIVO AND IN-VITRO INVASIVENESS OF A RAT COLON-CANCER CELL-LINE MAINTAINING E-CADHERIN EXPRESSION - AN ENHANCING ROLE OF TUMOR-ASSOCIATED MYOFIBROBLASTS

MT DIMANCHEBOITRELLuc VakaetP PUJUGUETB CHAUFFERTMS MARTINA HAMMANNFrans Van RoyMarcus MareelF MARTIN

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

INVASION PROMOTER VERSUS INVASION SUPPRESSOR MOLECULES - THE PARADIGM OF E-CADHERIN

Marcus MareelFrans Van RoyMarc Bracke

A1 Journal Article in MOLECULAR BIOLOGY REPORTS

Invasiveness in development and neoplasia

Marcus MareelFrans Van RoyP DE BAETSELIERLuc Vakaet

Bookchapter in Developmental Biology and Cancer

MICRO-ENCAPSULATION OF MDCK-RAS-E CELLS PREVENTS LOSS OF E-CADHERIN INVASION-SUPPRESSOR FUNCTION IN-VIVO

GMR VANDENBOSSCHEGK DEBRUYNEErik BruyneelG CLEMMINCKKris VleminckxFrans Van RoyMarcus Mareel

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

The invasion suppressor function of E-cadherin in mammary epithelioid cells

Marc BrackeStefan VermeulenErik BruyneelK VennekensGeorges De BruyneFrans Van RoyMarcus Mareel

1993

ENHANCEMENT OF TUMOR-NECROSIS-FACTOR CYTOTOXICITY BY LITHIUM-CHLORIDE IS ASSOCIATED WITH INCREASED INOSITOL PHOSPHATE ACCUMULATION.

Rudi BeyaertKaren HeyninckDirk De ValckF BOEYKENSFrans Van RoyWalther Fiers

A1 Journal Article in JOURNAL OF IMMUNOLOGY

EXPRESSION OF E-CADHERIN IN EMBRYOGENETIC INGRESSION AND CANCER INVASION.

Marcus MareelMarc BrackeFrans Van RoyLuc Vakaet

A1 Journal Article in INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Effect of bcl-2-proto-oncogene expression on cellular sensitivity to tumor necrosis factor-mediated cytotoxicity.

Bart VanhaesebroeckJC REEDD DEVALCKJohan GrootenT MIYASHITAS TANAKARudi BeyaertFrans Van RoyWalther Fiers

A1 Journal Article in ONCOGENE

HOW AND WHEN DO TUMOR-CELLS METASTASIZE.

Marcus MareelFrans Van RoyMarc Bracke

A1 Journal Article in CRITICAL REVIEWS IN ONCOGENESIS

Insulin-like growth factor I activates the invasion suppressor function of E-cadherin in MCF-7 human mammary carcinoma cells in vitro.

Marc BrackeBM VYNCKEErik BruyneelStefan VermeulenGK DEBRUYNENA VANLAREBEKEKris VleminckxFrans Van RoyMarcus Mareel

A1 Journal Article in BRITISH JOURNAL OF CANCER

LOSS OF EPITHELIAL DIFFERENTIATION AND GAIN OF INVASIVENESS CORRELATES WITH TYROSINE PHOSPHORYLATION OF THE E-CADHERIN BETA-CATENIN COMPLEX IN CELLS TRANSFORMED WITH A TEMPERATURE-SENSITIVE V-SRC GENE

J BEHRENSLuc VakaetR FRIISE WINTERHAGERFrans Van RoyMarcus MareelW BIRCHMEIER

A1 Journal Article in JOURNAL OF CELL BIOLOGY

Mechanisms of invasion: biological basis and clinical consequences

Marcus MareelMarc BrackeFrans Van Roy

A1 Journal Article in ANNALES DE BIOLOGIE CLINIQUE

NEOPLASTIC PROGRESSION OF HUMAN AND RAT INTESTINAL-CELL LINES AFTER TRANSFER OF THE RAS AND POLYOMA MIDDLE T-ONCOGENES

E CHASTRES EMPEREURY DIGIOIAN ELMAHDANIMarcus MareelKris VleminckxFrans Van RoyV BEXS EMAMIDA SPANDIDOS et al.

A1 Journal Article in GASTROENTEROLOGY

Sensitization of tumor cells to tumor necrosis factor action by the protein kinase inhibitor staurosporine

Rudi BeyaertBart VanhaesebroeckKaren HeyninckElke BooneDirk De ValckKlaus Schulze-OsthoffGuy HaegemanFrans Van RoyWalther Fiers

A1 Journal Article in CANCER RESEARCH

TUMOR-NECROSIS-FACTOR CYTOTOXICITY IS ASSOCIATED WITH PHOSPHOLIPASE-D ACTIVATION.

D DEVALCKRudi BeyaertFrans Van RoyWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

Tumor necrosis factor cytotoxicity is associated with activation of cellular phospholipases

Dirk De ValckRudi BeyaertFrans Van RoyWalther Fiers

Two pathways of tumor necrosis factor signal transduction: in vitro and in vivo implications

Walther FiersRudi BeyaertPeter BrouckaertAnje CauwelsWim DeclercqDirk De ValckB EveraerdtVera GoossensJohan GrootenGuy Haegeman et al.

1992

E-Cadherin expression: a counterbalance for cancer cell invasion.

Marcus MareelKris VleminckxStefan VermeulenMarc BrackeFrans Van Roy

A1 Journal Article in BULLETIN DU CANCER

Expression of an exogenous tumor-necrosis-factor (TNF) gene in TNF-sensitive cell-lines confers resistance to TNF-mediated cell-lysis.

Bart VanhaesebroeckEls DecosterXaveer VAN OSTADES VANBLADELAnne LenaertsFrans Van RoyWalther Fiers

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Homotypic cell-cell adhesion molecules and tumor invasion

Marcus MareelKris VleminckxStefan VermeulenY GaoLuc VakaetMarc BrackeFrans Van Roy

A1 Journal Article in PROGRESS IN HISTOCHEMISTRY AND CYTOCHEMISTRY

Mechanisms of Invasion and Metastasis

Marcus MareelP DE BAETSELIERFrans Van Roy

Modulation of invasion in vitro and in vivo

Marcus MareelK VLEMINCKXY GAONicolas Van LarebekeMarc BrackeFrans Van Roy

Synergistic induction of interleukin-6 by tumor necrosis factor and lithium chloride in mice: Possible role in the triggering and exacerbation of psoriasis by lithium treatment.

Rudi BeyaertK SCHULZEOSTHOFFFrans Van RoyWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

The invasion suppressor role of E-cadherin

Frans Van RoyK VleminckxLuc VakaetGeert BerxWalther FiersMarcus Mareel

Bookchapter in Metastasis : basic research and its clinical applications

Tumor necrosis factor : mechanism of action and its potential for anticancer therapy

W HersRudi BeyaertPeter BrouckaertEls DecosterDirk De ValckB EveraerdtJohan GrootenAnne LenaertsClaude LibertK Schulze-Osthoff et al.

Tumor-necrosis-factor : mechanism of action at the molecular, cellular and in vivo level

Walther FiersRudi BeyaertPeter BrouckaertEls DecosterDirk De ValckBart EveraerdtJohan GrootenAnne LenaertsClaude LibertK. Schulzeosthoff et al.

Tumour invasion : effects of cell adhesion and motility

Frans Van RoyMarcus Mareel

A2 Journal Article in TRENDS IN CELL BIOLOGY

1991

Arrest of MCF-7 cell migration by laminin in vitro: possible mechanisms

P CoopmanBruno VerhasseltMarc BrackeGeorges De BruyneV CastronovoM SobelJM FoidartFrans Van RoyMarcus Mareel

A1 Journal Article in CLINICAL & EXPERIMENTAL METASTASIS

DOWN-REGULATION OF E-CADHERIN EXPRESSION IN MADIN DARBY CANINE KIDNEY (MDCK) CELLS INSIDE TUMORS OF NUDE-MICE.

Marcus MareelJ BEHRENSW BIRCHMEIERGK DEBRUYNEKris VleminckxA HOOGEWIJSWC FIERSFrans Van Roy

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

Down-regulation of E-cadherin expression in Madin Darby canine kidney (MDCK) cells inside tumors of nude mice

M MAREELJ BEHRENSW BIRCHMEIERGeorges De BruyneK VLEMINCKXA HOOGEWUSWalther FiersFrans Van Roy

A2 Journal Article in Int. J. Cancer, 47, 922-928

Expression of the tumor necrosis factor gene in tumor cells correlates with reduced tumorigenicity and reduced invasiveness in vivo

Bart VanhaesebroeckMarcus MareelFrans Van RoyJohan GrootenWalther Fiers

A1 Journal Article in CANCER RESEARCH

GENETIC MANIPULATION OF E-CADHERIN EXPRESSION BY EPITHELIAL TUMOR-CELLS REVEALS AN INVASION SUPPRESSOR ROLE.

Kris VleminckxLuc VakaetMarcus MareelWalther FiersFrans Van Roy

A1 Journal Article in CELL

INFLUENCE OF BASEMENT-MEMBRANE MOLECULES ON DIRECTIONAL MIGRATION OF HUMAN BREAST CELL-LINES INVITRO.

PJ COOPMANMarc BrackeJC LISSITZKYGK DEBRUYNEFrans Van RoyJM FOIDARTMarcus Mareel

A1 Journal Article in JOURNAL OF CELL SCIENCE

Induction of inflammatory cell infiltration and necrosis in normal mouse skin by the combined treatment of tumor-necrosis-factor and lithium-chloride

Rudi BeyaertChristian De PotterBart VanhaesebroeckFrans Van RoyWalther Fiers

A1 Journal Article in AMERICAN JOURNAL OF PATHOLOGY

Lithium chloride potentiates tumor necrosis factor-induced and interleukin 1-induced cytokine and cytokine receptor expression

Rudi BeyaertKlaus Schulze-OsthoffFrans Van RoyWalther Fiers

A1 Journal Article in CYTOKINE

Mechanisms of Invasion and Metastasis.

Marcus MareelP DE BAETSELIERFrans Van Roy

Metastasemodellen.

Marcus MareelMarc BrackeP DE BAETSELIERFrans Van Roy

A3 Journal Article in TIJDSCHRIFT VOOR KANKER

Normal and chimeric avian embryo ecosystems of invasion

Marcus MareelMarc BrackeY GaoFrans Van Roy

A2 Journal Article in EUROPEAN ARCHIVES OF BIOLOGY

Numerical evaluation of the invasion of closely related cell lines into collagen type I gels

Luc VakaetKris VleminckxFrans Van RoyMarcus Mareel

A1 Journal Article in INVASION & METASTASIS

SPONTANEOUS ACQUISITION OF TUMORIGENICITY AND INVASIVENESS BY MOUSE LENS EXPLANT CELLS DURING CULTURE INVITRO.

L MESSIAENS QIANG DEBRUYNEE BOGHAERTT MOENSM RABAEYFrans Van RoyMarcus Mareel

A1 Journal Article in IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY

Tumour-necrosis-factor-mediated cytotoxicity is correlated with phospholipase-A2 activity, but not with arachidonic acid release per se

Philip SuffysRudi BeyaertDirk De ValckBart VanhaesebroeckFrans Van RoyWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

Two discrete types of tumor necrosis factor-resistant cells derived from the same cell line

Bart VanhaesebroeckSigrid Van BladelAnne LenaertsPhilippe SuffysRudi BeyaertRudolf LucasFrans Van RoyWalther Fiers

A1 Journal Article in CANCER RESEARCH

1990

Cytotoxic activity of tumor necrosis factor is inhibited by amiloride derivatives without involvement of the Na+/H+ antiporter

B VanhaesebroeckEJ Jr CragoeJ PouysségurRudi BeyaertFrans Van RoyWalther Fiers

A1 Journal Article in FEBS LETTERS

HORMONE SENSITIVITY INVITRO AND INVIVO OF V-RAS-TRANSFECTED MCF-7 CELL DERIVATIVES.

Frans Van RoyMarcus MareelKris VleminckxRudi BeyaertWalther FiersN DEVLEESCHOUWERC MUQUARDTN LEGROSMarc BrackeG LECLERCQ

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

In vitro and in vivo action of tumor necrosis factor

Walther FiersRudi BeyaertPeter BrouckaertBart EveraerdtGuy HaegemanClaude LibertPhilip SuffysNozomi TakahashiJan TavernierSigrid Van Bladel et al.

Inhibition by glucocorticoids of tumor necrosis factor-mediated cytotoxicity: evidence against lipocortin involvement

Rudi BeyaertPhilip SuffysFrans Van RoyWalther Fiers

A1 Journal Article in FEBS LETTERS

Mechanismen van tumorale invasie en metastase.

Marcus MareelP DE BAETSELIERFrans Van Roy

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Modulation of cellular susceptibility to the cytotoxic/cytostatic action of tumor necrosis factor by adenovirus E1 gene expression is cell type-dependent

Bart VanhaesebroeckH Th Marc TimmersGijsbertus J PronkFrans Van RoyAlex J van der EbWalther Fiers

A1 Journal Article in VIROLOGY

PARTIAL TRANSFORMATION OF HUMAN TUMOR-CELL LINES SHOWING DEFECTIVE INTERACTION BETWEEN UNUSUAL P53 GENE-PRODUCT AND SV40 LARGE-T ANTIGEN.

Frans Van RoyG LIEBAUTMarcus MareelWalther Fiers

A1 Journal Article in ONCOGENE

The invasive phenotypes

Marcus MareelFrans Van RoyPatrick De Baetselier

A1 Journal Article in CANCER AND METASTASIS REVIEWS

Tumor-necrosis-factor : mechanism of action at the molecular, cellular and in vivo level

Walther FiersRudi BeyaertPeter BrouckaertBart EveraerdtJohan GrootenAnne LenaertsClaude LibertP. SuffysNozomi TakahashiJan Tavernier et al.

A1 Journal Article in SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

1989

Dissecting tumor cell invasion: epithelial cells acquire invasive properties following the loss of uvomorulin-mediated cell-cell adhesion.

J BEHRENSMarcus MareelFrans Van RoyW BIRCHMEIER

A1 Journal Article in JOURNAL OF CELL BIOLOGY

EFFECT OF ONCOGENE TRANSFECTION OR PASSAGE INVIVO ON MALIGNANT PHENOTYPES OF RAT2-CELLS.

Frans Van RoyP COOPMANPhilip SuffysG LIEBAUTKris VleminckxJ GAOCH DRAGONETTIWalther FiersMarcus Mareel

A1 Journal Article in ANTICANCER RESEARCH

Lithium chloride potentiates tumor necrosis factor-mediated cytotoxicity in vitro and in vivo

Rudi BeyaertBart VanhaesebroeckPhilip SuffysFrans Van RoyWalther Fiers

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oncogenes and tumor progression : state of the art

Frans Van RoyMarcus Mareel

TNF in combination with interferon-γ is cytotoxic to normal, untransformed mouse and rat embryo fibroblast-like cells

Philip SuffysRudi BeyaertFrans Van RoyWalther Fiers

A1 Journal Article in ANTICANCER RESEARCH

Tumorigenicity, invasiveness and metastatic capability of FR3T3 rat cells before and after transfection with bovine papilloma virus type 1 DNA.

P COOPMANFrans Van RoyC DRAGONETTIJ GAOWalther FiersG MENEGUZZIMarcus Mareel

A1 Journal Article in CLINICAL & EXPERIMENTAL METASTASIS

1988

Correlates of malignancy in cultured cells

Marcus MareelFrans Van RoyL MESSIAENNicolas Van LarebekeE BOGHAERT

Bookchapter in New frontiers in cytology : modern aspects of research and practice

Involvement of a serine protease in tumour-necrosis-factor-mediated cytotoxicity

Philip SuffysRudi BeyaertFrans Van RoyWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

Molecular biology of minimal invasion

Marcus MareelFrans Van RoyErik BruyneelJ BolscherD SchallierMarc De Mets

Bookchapter in Minimal neoplasia

Tumor necrosis factor and interleukin 1 activate phospholipase in rat chondrocytes

Philip SuffysFrans Van RoyWalther Fiers

A1 Journal Article in FEBS LETTERS

1987

Gene cloning and structure: function relationship of cytokines such as TNF and interleukins

Walther FiersRudi BeyaertPeter BrouckaertBart EveraerdtGuy HaegemanPhilip SuffysJan TavernierPeter VandenabeeleBart VanhaesebroeckXaveer Van Ostade et al.

A1 Journal Article in IMMUNOLOGY LETTERS

Pathology of tumours produced in syngeneic Fischer rats by fibroblast-like cells before and after transfections with oncogenes.

J GAOFrans Van RoyL MESSIAENJ COSAERTG LIEBAUTP COOPMANWalther FiersMarcus Mareel

A1 Journal Article in PATHOLOGY RESEARCH AND PRACTICE

Qualitative and quantitative analysis of tumour invasion in vivo and in vitro.

Marcus MareelFrans Van RoyLM MESSIAENER BOGHAERTErik Bruyneel

A1 Journal Article in JOURNAL OF CELL SCIENCE

Reduced tumour necrosis factor-induced cytotoxicity by inhibitors of the arachidonic acid metabolism

Philip SuffysRudi BeyaertFrans Van RoyWalther Fiers

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structure-function relationship of tumor necrosis factor and its mechanism of action

Walther FiersPeter BrouckaertAlfred L GoldbergIsis C KettelhutPhilip SuffysJan TavernierBart VanhaesebroeckFrans Van Roy

A1 Journal Article in CIBA FOUNDATION SYMPOSIA

Tumor necrosis factor: a potential antitumor agent?

Walther FiersRudi BeyaertPeter BrouckaertBart EveraerdtPhilip SuffysJan TavernierBart VanhaesebroeckFrans Van Roy

A1 Journal Article in JOURNAL OF INTERFERON RESEARCH

1986

Are oncogenes involved in invasion and metastasis ?

Marcus MareelFrans Van Roy

A1 Journal Article in ANTICANCER RESEARCH

Expression of cell surface glycoproteins in tumour invasion in vitro

Marcus MareelC DragonettiR HoogheErik BruyneelMarc BrackeFrans Van RoyJ GaoGeorges De BruyneWalther Fiers

Genome organisation of the FBR-osteosarcoma virus complex : identification of a subgenomic fos-specific message

L MichielsFrans Van RoyL de Saint GeorgeJozef Merregaert

A1 Journal Article in VIRUS RESEARCH

Invasiveness and metastatic capability of rat fibroblast-like cells before and after transfection with immortalizing and transforming genes.

Frans Van RoyLudwine MessiaenGilberte LiebautJin GaoChristian H DragonettiWalther FiersMarcus Mareel

A1 Journal Article in CANCER RESEARCH

1984

Protein kinase activities in immune complexes of Simian Virus 40 large T-antigen and transformation-associated cellular p53 protein

Frans Van RoyLucie FransenWalther Fiers

A1 Journal Article in MOLECULAR AND CELLULAR BIOLOGY

1983

Changes in gene expression and protein phosphorylation in murine cells, transformed or abortively infected with wild type and mutant Simian Virus 40

Lucie FransenFrans Van RoyWalther Fiers

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Improved localization of phosphorylation sites in simian virus 40 large T antigen

Frans Van RoyLucie FransenWalther Fiers

A1 Journal Article in JOURNAL OF VIROLOGY

Metabolic turnover of phosphorylation sites in simian virus 40 large T antigen

Frans Van RoyLucie FransenWalther Fiers

A1 Journal Article in JOURNAL OF VIROLOGY

1981

Phosphorylation patterns of tumour antigens in cells lytically infected or transformed by simian virus 40

Frans Van RoyLucie FransenWalther Fiers

A1 Journal Article in JOURNAL OF VIROLOGY

1979

Isolation and characterization of a specific deletion mutant of human adenovirus type 2

Frans Van RoyGilbert EnglerWalther Fiers

A1 Journal Article in VIROLOGY

1978

Interference with simian virus 40 DNA replication by adenovirus type 2 during mixed infection of monkey cells

Frans Van RoyWalther Fiers

A1 Journal Article in JOURNAL OF VIROLOGY

Structure of the components of the adenovirus-simian virus 40 hybrid population Ad2++HEY and reciprocal molecular interactions

Frans Van RoyWalther Fiers

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

1977

Mycoplasma in African green monkey kidney cell cultures : biochemical detection and effects in virus infected cells

Frans Van RoyWalther Fiers

A1 Journal Article in IN VITRO-JOURNAL OF THE TISSUE CULTURE ASSOCIATION